CN105466985A - Electrode for biological detection test piece and manufacturing method thereof - Google Patents
Electrode for biological detection test piece and manufacturing method thereof Download PDFInfo
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Abstract
The invention discloses an electrode for a biological detection test piece. The electrode for the biological detection test piece comprises a substrate, a non-conductive adhesive layer arranged on the substrate and a first metal layer arranged on the non-conductive adhesive layer. The non-conductive adhesive layer comprises a sensitizer and an activator, so that the process or the material used for manufacturing the electrode for the biological detection test piece has elasticity, and the manufactured electrode for the biological detection test piece still has good conductive property. The invention also discloses a method for manufacturing the electrode for the biological detection test piece.
Description
Technical field
The present invention about a kind of electrode and its manufacture method, particularly about a kind of electrode for biological detecting test piece and its manufacture method.
Background technology
In recent years, the incidence of domestic diabetes, hypercholesterolemia or gout rises every year, and the disease of diabetes and gout is except diet and medicine control, most important, is that oneself detects.Therefore, for this kind of disease, can be convenient for carrying use for detecting the biological detecting test piece of blood sugar, cholesterol or uric acid, commercially demand is very large.
The electrode of the test strip manufactured by current most of coherent detection test piece manufacturer all makes in the mode of screen printing, and its conductive material is based on carbon or silver.But electrode finished product manufactured by the technique of screen printing has the shortcomings such as output is unstable, resistance value is unstable, accuracy is not high, consume electric power is large, reaction velocity is slow.
In order to overcome the above problems, the open electrode for biological detecting test piece and its production method in No. I396844, Taiwan Patent, and effectively can make up the shortcoming of above-mentioned general test strip.But, in No. I396844, Taiwan Patent to propose the selection elasticity of electrode structure to technique or material lower.If when there is no increasing price of raw materials on required equipment or market when producing, will cause and be difficult to find replacement scheme and make production cost improve.
Summary of the invention
(1) technical matters that will solve
In view of the above-mentioned problem knowing technology, object of the present invention is just to provide a kind of electrode for biological detecting test piece, can maintain high-quality with the electrode being used in biological detecting test piece, has very big elasticity when producing to the selection of technique or material simultaneously.
(2) technical scheme
According to object of the present invention, a kind of electrode for biological detecting test piece is proposed.Electrode for biological detecting test piece comprises substrate, the first metal layer being arranged at the non-conductive glue layer on substrate and being arranged on non-conductive glue layer.Non-conductive glue layer comprises sensitizer and activator.
Preferably, the material of the first metal layer can be palladium.
Preferably, the electrode for biological detecting test piece also can comprise the second metal level be arranged on the first metal layer.The material of the first metal layer can be palladium, and the material of the second metal level can be gold.
Preferably, the electrode for biological detecting test piece also can comprise the second metal level be arranged on the first metal layer and the 3rd metal level be arranged on the second metal level.The material of the first metal layer can be palladium, and the material of the second metal level can be nickel, and the material of the 3rd metal level can be gold or palladium.
Preferably, the electrode for biological detecting test piece also can comprise the second metal level be arranged on the first metal layer, the 4th metal level being arranged at the 3rd metal level on the second metal level and being arranged on the 3rd metal level.The material of the first metal layer can be copper, and the material of the second metal level can be palladium, and the material of the 3rd metal level can be nickel, and the material of the 4th metal level can be gold or palladium.
Preferably, sensitizer can comprise glucose, diamine, hydroborate, stannous chloride, amino borane compound, aldehydes, hypophosphites or tartrate, and activator can comprise particulate or the compound of nickel, cobalt, palladium, steel or copper.
Preferably, non-conductive glue layer also can comprise bonding agent, and bonding agent can comprise polyvinyl acetate, polyvinyl alcohol (PVA) or isopropyl titanate.
Preferably, non-conductive glue layer also can comprise bonding agent, and bonding agent can comprise acrylate copolymer or alkoxide.
Preferably, substrate can be pliability plastic base, aluminium base, ceramic substrate, glass substrate or glass fibre (FR4) substrate.
According to another object of the present invention, the method for a kind of manufacture for the electrode of biological detecting test piece is proposed.The method comprises provides substrate, and substrate forms non-conductive glue layer, and non-conductive glue layer comprises sensitizer and activator, and on non-conductive glue layer, form one or more layers metal level.
In sum, according to the electrode for biological detecting test piece of the present invention, it can have one or more following advantage:
(1) for the electrode of biological detecting test piece by the non-conductive glue layer containing sensitizer and activator, electroless plating has the metal level of superperformance to various substrate thus.
(2) for the electrode of biological detecting test piece by the non-conductive glue layer containing sensitizer and activator, the technique of the electrode of making biological detecting test piece can be made thus more flexible.
Accompanying drawing explanation
Fig. 1 is the schematic configuration diagram of the electrode for biological detecting test piece of the first embodiment of the present invention.
Fig. 2 is the schematic configuration diagram of the electrode for biological detecting test piece of the second embodiment of the present invention.
Fig. 3 is the schematic configuration diagram of the electrode for biological detecting test piece of the third embodiment of the present invention.
Fig. 4 is the schematic configuration diagram of the electrode for biological detecting test piece of the fourth embodiment of the present invention.
Fig. 5 is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the fifth embodiment of the present invention.
Fig. 6 is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the sixth embodiment of the present invention.
Fig. 7 is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the seventh embodiment of the present invention.
Fig. 8 is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the eighth embodiment of the present invention.
Fig. 9 is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the ninth embodiment of the present invention.
Figure 10 is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the tenth embodiment of the present invention.
Figure 11 is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the 11st embodiment of the present invention.
Figure 12 is the three-dimensional exploded view of the biological detecting test piece comprising the electrode for biological detecting test piece of the present invention.
The chart of the data of Figure 13 measured by the biological detecting test piece of display the 12nd figure.
Figure 14 for comprise carbon/silver (C/Ag) electrode biological detecting test piece measured by the chart of data.
The chart of the data of Figure 15 measured by the biological detecting test piece of display the 12nd figure and the Data Comparison measured by YSI-2300 blood sugar analyzer.
Embodiment
With reference to accompanying drawing; and be described in detail as follows with the expression-form of embodiment; and wherein used accompanying drawing; its object is only the use of signal and aid illustration book; may not be actual proportions after the invention process and precisely configure, therefore the ratio of accompanying drawing and configuration relation should not limited to the technical scheme protection domain of the present invention on reality is implemented.
Hereinafter with reference to relevant drawings, the embodiment according to the electrode for biological detecting test piece of the present invention is described, for ease of understanding, the same components in following embodiment illustrates with identical Reference numeral.
With reference to Fig. 1, it is the schematic configuration diagram of the electrode for biological detecting test piece of the first embodiment of the present invention.In figure, the electrode for biological detecting test piece comprises substrate 100, the first metal layer 300 being arranged at the non-conductive glue layer 200 on substrate 100 and being arranged on non-conductive glue layer 200.Non-conductive glue layer 200 comprises sensitizer and activator.
In general, in order to desired metal will be made to be attached on substrate, the mode of binding or electroplating can be used.Wherein, usually having more uniform thickness in electroless plating mode, concerning the electrode for detecting, usually also can obtain the good electric signal of quality thus.But, and not all substrate can directly use the mode of electroless plating to be adhered on it by metal.Such as, under the help not having external force, metal is not easy produce redox reaction needed for electroless plating and be attached to plastics or ceramic substrate.
Therefore, in the present invention, before electroless plating the first metal layer 300, non-conductive glue layer 200 can be first set on the substrate 100, containing sensitizer and activator in non-conductive glue layer 200.Sensitizer and activator can actings in conjunction, and make the surface nature of substrate be easy to produce electroless plating reaction concerning predetermined metal.Specifically, high chemically active material will be produced after sensitizer and activator acting in conjunction, effectively can reduce the chemical potential energy of required elimination when carrying out electroless plating thus, thus inspire the self-catalyzed reaction of metal host in electroplate liquid.It is worth mentioning that, non-conductive glue layer 200 can not need additional technique (as laser treatment or acid cleaning process) just can make the surface active of substrate 100 and be easy to produce electroless plating reaction.Thus, when the substrate 100 being provided with non-conductive glue layer 200 is immersed metal host composition is the electroplate liquid of the material of the first metal layer 300, the surface that metal just can be provided with non-conductive glue layer 200 at substrate 100 produces the redox reaction of self-catalysis, and the surface being provided with non-conductive glue layer 200 at substrate 100 forms the first metal layer 300.In certain embodiments, the material of the first metal layer can be copper, palladium, nickel or cobalt.
Preferably, the material of the first metal layer 300 can be palladium.
Refer again to Fig. 1, in the electrode of biological detecting test piece, outermost metal must have satisfactory electrical conductivity, such as palladium or gold.And of the present invention in the electrode of biological detecting test piece, due to the existence of non-conductive glue layer 200, palladium can easily through the mode of electroless plating be arranged on there is non-conductive glue layer 200 surface on.So the material of the first metal layer 300 can be palladium, and the first metal layer 300 is made to be the outermost metal level of electrode for biological detecting test piece.That is, only need substrate 100, non-conductive glue layer 200 and the first metal layer 300 just can be configured for the main body of the electrode of biological detecting test piece.As shown in fig. 1, wherein, material is that the thickness of the first metal layer 300 of palladium changes by the process conditions of electroless plating, and then is adjusted to the optimum thickness of the electrode being suitable for biological detecting test piece.The technique of this embodiment significantly can simplify because of structure, thus reduces process costs.
Preferably, the electrode for biological detecting test piece also can comprise the second metal level 400 be arranged on the first metal layer 300.The material of the first metal layer 300 can be palladium, and the material of the second metal level 400 can be gold.
With reference to Fig. 2, it is the schematic configuration diagram of the electrode for biological detecting test piece of the second embodiment of the present invention.As shown in the figure, electrode for biological detecting test piece of the present invention can make the selection of the material of metal level have elasticity, therefore the second metal level 400 can be set at the first metal layer 300 again, and make the second metal level 400 be the outermost metal level of electrode for biological detecting test piece.Now the material of the first metal layer 300 can still be palladium, but with the first embodiment by comparison, because the first metal layer 300 is now as middle medium layer, therefore thickness does not need too thick.And the material being arranged on the second metal level 400 on the first metal layer 300 can be gold, thus the electrode being used in biological detecting test piece has satisfactory electrical conductivity.
Preferably, the electrode for biological detecting test piece also can comprise the second metal level 400 be arranged on the first metal layer 300 and the 3rd metal level 500 be arranged on the second metal level 400.The material of the first metal layer 300 can be palladium, and the material of the second metal level 400 can be nickel, and the material of the 3rd metal level 500 can be gold or palladium.
With reference to Fig. 3, it is the schematic configuration diagram of the electrode for biological detecting test piece of the third embodiment of the present invention.As shown in the figure, the metal level of the electrode for biological detecting test piece of the present invention can comprise the 3rd metal level 500 again, and it is arranged on the second metal level 400.Due in this embodiment, 3rd metal level 500 is outermost metal level, therefore the material of the 3rd metal level 500 can be the material gold of the second metal level in the material palladium of the first metal layer in the first embodiment or the second embodiment, and its conduction property does not have too large change.Material as the first metal layer 300 of medium layer can be still palladium, and the thickness of palladium can be thinner and be the thin layer of palladium.But, material equally as the second metal level 400 of medium layer now can be nickel, to reduce the use amount of noble metal, thus reduce the manufacturing cost of the electrode being used for biological detecting test piece, but the conduction property of the electrode for biological detecting test piece of the present embodiment does not substantially change and still has satisfactory electrical conductivity.
Preferably, the electrode for biological detecting test piece also can comprise the second metal level 400 be arranged on the first metal layer 300, the 4th metal level 600 being arranged at the 3rd metal level 500 on the second metal level 400 and being arranged on the 3rd metal level 500.The material of the first metal layer 300 can be copper, and the material of the second metal level 400 can be palladium, and the material of the 3rd metal level 500 can be nickel, and the material of the 4th metal level 600 can be gold or palladium.
With reference to Fig. 4, it is the schematic configuration diagram of the electrode for biological detecting test piece of the fourth embodiment of the present invention.Same as above, the selection of the electrode pair material for biological detecting test piece of the present invention has elasticity.Therefore, in this embodiment, the metal level for the electrode of biological detecting test piece can be four-layer structure.Because outermost metal level need have satisfactory electrical conductivity, therefore the material of the 4th metal level 600 can be the material gold of the second metal level in the material palladium of the first metal layer in the first embodiment or the second embodiment, and its conduction property does not have too large change.Now, the material as the first metal layer 300 of medium layer can be copper.The material of the second metal level 400 can be palladium, and the thickness of palladium can be thinner and be the thin layer of palladium.The material of the 3rd metal level 500 can be nickel, and the 4th metal level 600 is generated thereon.In this embodiment, although the processing step of electroless plating is more, but the use amount of noble metal can be reduced, thus reduce the cost of material aspect.
In a particular embodiment, the thickness of non-conductive glue layer 200 can be about 1 to 20u " (microinch microinch); The material of the first metal layer 300 can be copper, and thickness can be about 1 to 30u "; The material of the second metal level 400 can be palladium, and thickness can be about 1 to 10u "; The material of the 3rd metal level 500 can be nickel, and thickness can be about 20 to 200u "; And the 4th the material of metal level 600 can be gold, thickness can be about 0.5 to 10u ".Or in another specific embodiment, as hereinbefore, but the material of the 4th metal level 600 can be palladium for non-conductive glue layer 200, the first metal layer 300, second metal level 400 and the 3rd metal level 500, and thickness can be about 1 to 20u ".
Such as, the material of the first metal layer 300 grown up on the substrate 100 is in the situation of copper, then the thickness of the non-conductive glue layer 200 between the first metal layer 300 and substrate 100 can be 2u ", and the thickness of the first metal layer 300 can be 4u ".The first metal layer 300 is formed with commercially available Copper Foil if want, general requirements thickness because of commercially available Copper Foil is 12u "; and thickness 4u " Copper Foil belong to special requirement, therefore use commercially available Copper Foil to form thickness 4u " the first metal layer 300 cost will be made significantly to improve.Relatively, it be the method for the first metal layer 300 of copper is electroless plating that the present invention forms material, only need adjusting process parameter just can control the thickness of the first metal layer 300 easily, therefore can originally form thin (if thickness is for 4u ") the first metal layer 300 with relatively low one-tenth.For in the electrode of biological detecting test piece, the thickness due to intermediate metal layer does not need too thick, therefore adopts structure and method disclosed by the invention can control intermediate metal layer easily in desired thickness, and then reduces material usage and manufacturing cost.
In sum, for the electrode pair technique of biological detecting test piece and the selection of material, there is elasticity due to of the present invention, can freely according to the situation of existing equipment and material when therefore producing, select the mode of production of lower cost, and make the produced electrode for biological detecting test piece still maintain good conduction property.The embodiment of non-conductive glue layer 200 used in the present invention and detailed process will be described afterwards.
Preferably, sensitizer can comprise glucose, diamine, hydroborate, stannous chloride, amino borane compound, aldehydes, hypophosphites or tartrate, and activator can comprise particulate or the compound of nickel, cobalt, palladium, steel or copper.
The sensitizer and activator that can change substrate 100 surface nature is comprised in the non-conductive adhesive forming non-conductive glue layer 200.Specifically; sensitizer can comprise glucose, diamine, hydroborate, stannous chloride, amino borane compound, aldehydes, hypophosphites or tartrate; and can with the activator adding non-conductive adhesive; as particulate or the compound of nickel, cobalt, palladium, steel or copper, produce and there is high chemically active material.Such as; the non-conductive adhesive of non-conductive glue layer 200 can comprise the paste of stannous chloride, palladium bichloride, hydrochloric acid, water and corresponding technique used; wherein react as the stannous chloride of sensitizer and palladium bichloride; produce the metal particle of palladium or coordination compound, and this type of material has high chemical activity and can make it rear electroless plating time electroplate liquid in metal host produce self-catalyzed reaction and be plated on non-conductive glue layer 200 and form predetermined metal layer.Aforesaid paste may correspond to technology category used when being arranged on substrate 100 by non-conductive adhesive, and during as use screen printing, paste can be the colloid paste of titanium dioxide.Certainly, the present invention is not limited thereto, any sensitizer of the surface of substrate 100 being had be easy to electroless plating and activator all should be contained in the present invention.
Preferably, non-conductive glue layer 200 also can comprise bonding agent, and bonding agent can comprise polyvinyl acetate, polyvinyl alcohol (PVA) or isopropyl titanate.Or bonding agent can comprise acrylate copolymer or alkoxide.
In order to make non-conductive glue layer 200 can clearly form required line pattern in process, or can direct forming in process, the non-conductive adhesive for the formation of non-conductive glue layer 200 can comprise bonding agent, to make itself having certain stickiness.According to the kind of bonding agent, form non-conductive glue layer 200 arranging non-conductive adhesive after, laser technology or thermal process can be utilized to make it solidify.In addition, bonding agent contributes to strengthening the tack between the first metal layer 300 and substrate 100, and the electrode being used in biological detecting test piece has better structural strength.
Preferably, substrate 100 can be pliability plastic base, aluminium base, ceramic substrate, glass substrate or glass fibre (FR4) substrate.
Because non-conductive glue layer 200 used in the present invention has the character of activation substrate surface, therefore almost various substrate all can be used to make the substrate 100 for the electrode of biological detecting test piece.Due to non-conductive characteristic, the metal substrate of such as aluminium base also can as substrate 100 used in the present invention.In an embodiment, substrate 100 used in the present invention can be polyethylene terephthalate (PET) substrate, and its thickness can be about 0.01 to 1 centimetre.In another embodiment, substrate 100 can be ceramic/glass/aluminium base, and its thickness can be about 0.1 to 2 centimetre.
In addition, when substrate 100 used in the present invention is pliability plastic base, the bendable plastic base used can comprise polyester terephthalate (PET) substrate, poly-imines (PI) substrate, Polyvinylchloride (PVC) substrate or polypropylene (PP) substrate.
Next will accompanying drawing be coordinated to describe the technique that can make the electrode for biological detecting test piece of the present invention in detail, thus show the electrode for biological detecting test piece of the present invention and can be formed by kinds of processes, therefore in the selection of technique, there is elasticity.Should be noted, the present invention is not limited to this, has the electrode for biological detecting test piece that is identical or similar functions structure also should be contained in category of the present invention manufactured by other technique of any use with the electrode for biological detecting test piece disclosed in this invention.
With reference to Fig. 5, it is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the fifth embodiment of the present invention.
In step s 11, can first according to the metallic circuit pattern that will be formed afterwards to make half tone.And in step s 12, half tone can be utilized to be printed on by non-conductive adhesive on substrate 100, non-conductive glue layer 200 thickness now formed is about 1 to 20u ", and there is predetermined line pattern.In step s 13, can heat-treat the substrate 100 being provided with non-conductive glue layer 200, thermal treatment can use baking box to carry out, and temperature is about 30 to 150 degree Celsius, and the time is about 10 to 120 minutes.After the surface of sandbag to substrate 100 and non-conductive glue layer 200 can be used afterwards to grind, then carry out subsequent step, to promote the quality of electroless plating.In step S14, the electroplate liquid that change smithcraft uses according to the predetermined metal level grown up to, and can comprise different metal host, and corresponding sequestrant, alkali, formaldehyde and stabilization agent.Substrate 100 surface now owing to being provided with non-conductive glue layer 200 has been suitable for carrying out electroless plating, thus metal can only transmit redox reaction and be arranged on there is non-conductive glue layer 200 substrate 100 on the surface.That is, the first metal layer 300 of generation will directly have scheduled circuit pattern.Now according to required electrode structure, sequentially can carry out the chemical plating process of other metal level, as described in aforementioned second embodiment, the 3rd embodiment or the 4th embodiment.The mode generating other metal level is substantially identical with the mode generating the first metal layer 300, the metal host of difference only in electroplate liquid.The feature of this embodiment, for processing step is few and simple, can reduce the time needed for technique and cost.
With reference to Fig. 6, it is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the sixth embodiment of the present invention.
In the step s 21, can first widen about 0.1 to 0.5 centimetre to make half tone according to the metallic circuit pattern that will be formed afterwards.That is, the pattern now on half tone is by more than the width of scheduled circuit about 0.1 to 0.5 centimetre.In step S22, half tone can be utilized to be printed on substrate 100 by non-conductive adhesive, non-conductive glue layer 200 thickness now formed is about 1 to 20u ", and there is the predetermined line pattern widened.In step S23, can heat-treat the substrate 100 being provided with non-conductive glue layer 200, thermal treatment can use baking box to carry out, and temperature is about 30 to 150 degree Celsius, and the time is about 10 to 120 minutes.After the surface of sandbag to substrate 100 and non-conductive glue layer 200 can be used afterwards to grind, then carry out subsequent step, to promote the quality of electroless plating.In step s 24 which, photolithography processes can be utilized, part on non-conductive glue layer 200 outside scheduled circuit pattern encloses screen layer, that is, screen layer on non-conductive glue layer 200 can have the width of about 0.1 to 0.5 centimetre on the limit of non-conductive glue layer 200, and can have the opening of scheduled circuit pattern in the middle of screen layer.Screen layer can be photo-conductive film or ink.In step s 25, the metal level of single or multiple lift is formed on the non-conductive glue layer 200 of non-conductively-closed layer covering by useization smithcraft, changes smithcraft identical or similar with the change smithcraft of abovementioned steps S14, therefore does not repeat.Now metal only can be formed on the surface of the non-conductive glue layer 200 that non-conductively-closed layer covers, thus forms scheduled circuit pattern.In step S26, first use alkaline liquid or corresponding liquid to remove screen layer, unnecessary non-conductive glue layer 200 removed by the volatility liquid or the corresponding liquid that re-use such as alcohol or butanone.The feature of this embodiment is less compared with the next required non-conductive adhesive of the 5th embodiment, can save material cost.In addition, the line pattern resolution formed with photolithography processes is better, using having preferably signal transmission quality as when being used for the electrode of biological detecting test piece.
With reference to Fig. 7, it is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the seventh embodiment of the present invention.
Step S31, S32 and the S33 of this embodiment are identical with S21, S22 and the S23 of the 6th embodiment respectively, therefore do not repeat.After the surface of sandbag to substrate 100 and non-conductive glue layer 200 can be used afterwards to grind, then carry out subsequent step, to promote the quality of electroless plating.In S34, utilize photolithography processes by screen layer with scheduled circuit pattern setting on non-conductive glue layer 200, that is, now the pattern width of screen layer can be fewer than the pattern width of non-conductive glue layer 200 about 0.1 to 0.5 centimetre.Screen layer can be photo-conductive film or ink.In step s 35, first use alkaline liquid or corresponding liquid to remove screen layer, unnecessary non-conductive glue layer 200 removed by the volatility liquid or the corresponding liquid that re-use such as alcohol or butanone.In step S36, the metal level of single or multiple lift is formed at by useization smithcraft to be had on the non-conductive glue layer 200 of scheduled circuit pattern, changes smithcraft substantially identical or similar with the change smithcraft of the step S14 of the 5th embodiment, therefore does not repeat.The feature of this embodiment is less compared with the next required non-conductive adhesive of the 5th embodiment, can save material cost.In addition, the line pattern resolution formed with photolithography processes is better, using having preferably signal transmission quality as when being used for the electrode of biological detecting test piece.
With reference to Fig. 8, it is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the eighth embodiment of the present invention.
In step S41, utilizing the mode that 3D prints, forming non-conductive glue layer 200 by there being the non-conductive adhesive of scheduled circuit pattern and thickness to be arranged on substrate 100.Step S42 and S43 is substantially identical or similar with the step S13 of the 5th embodiment and S14 respectively, therefore does not repeat.The feature of this embodiment can utilize 3D printing quick Fabrication to go out finished product after designing circuit, can reduce and be designed into manufacturing lead time, be convenient to fast verification finished product effect.
With reference to Fig. 9, it is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the ninth embodiment of the present invention.
In step s 51, be arranged at by non-conductive adhesive on the whole surface of substrate 100, the mode arranging non-conductive adhesive can be the mode of spary, coating or printing.In step S52, can heat-treat the substrate 100 being provided with non-conductive glue layer 200, heat treated parameter can be identical with the step S13 of the 5th embodiment, therefore do not repeat.In step S53, utilizationization smithcraft forms the first metal layer 300 on non-conductive glue layer 200, and now the first metal layer 300 covers the whole surface of non-conductive glue layer 200.In step S54, photolithography processes is utilized to be arranged on the first metal layer 300 by the screen layer forming scheduled circuit pattern.In step S55, etch the first metal layer 300 that non-conductively-closed layer covers, to make the first metal layer 300 stayed, there is scheduled circuit pattern.After removing the non-conductive glue layer outside screen layer and scheduled circuit pattern, carry out the follow-upization smithcraft of step S56, to be arranged on the first metal layer 300 by other metal level.If it is noted that the manufactured electrode structure for biological detecting test piece is as the first embodiment, then the step S56 of this embodiment can omit.
With reference to Figure 10, it is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the tenth embodiment of the present invention.
The step S61 of this embodiment and S62 is identical with S51 and S52 of the 9th embodiment respectively, therefore does not repeat.In step S63, photolithography processes is utilized to be arranged on non-conductive glue layer 200 by the screen layer with scheduled circuit pattern, then the volatility liquid of such as alcohol or butanone or corresponding liquid is used to remove the non-conductive glue layer 200 of non-conductively-closed layer covering, re-use alkaline liquid or corresponding liquid removal screen layer, to leave the non-conductive glue layer 200 with scheduled circuit pattern.In step S64, the metal level of single or multiple lift is formed at by useization smithcraft to be had on the non-conductive glue layer 200 of scheduled circuit pattern, changes smithcraft substantially identical or similar with the change smithcraft of the step S14 of the 5th embodiment, therefore does not repeat.
With reference to Figure 11, it is the process flow diagram of manufacture for the method for the electrode of biological detecting test piece of the 11st embodiment of the present invention.
The step S71 of this embodiment and S72 is identical with S51 and S52 of the 9th embodiment respectively, therefore does not repeat.In step S73, photolithography processes is utilized screen layer to be covered in part beyond non-conductive glue layer 200 scheduled circuit pattern.In step S74, the metal level of single or multiple lift is formed on the non-conductive glue layer 200 of non-conductively-closed layer covering by useization smithcraft, changes smithcraft substantially identical or similar with the change smithcraft of the step S14 of the 5th embodiment, therefore does not repeat.That is, after step S74, namely the single or multiple lift metal level be formed on non-conductive glue layer has scheduled circuit pattern.In step S75, first use alkaline liquid or corresponding liquid to remove screen layer, re-use the volatility liquid of such as alcohol or butanone or the non-conductive glue layer 200 of corresponding liquid removal non-predetermined line pattern.
With reference to Figure 12, it is the three-dimensional exploded view of the biological detecting test piece comprising the electrode for biological detecting test piece of the present invention.Biological detecting test piece can comprise substrate 10, electrode layer 20, bioactivator 30, middle partition 40 and upper cover 50.In use, substrate 10, electrode layer 20, bioactivator 30, middle partition 40 combine with upper cover 50 and form overall biological detecting test piece.
Electrode for biological detecting test piece of the present invention can directly for the manufacture of biological detecting test piece for detecting the biological parameter of blood sugar, cholesterol, uric acid, protoheme (Hb), and be exemplary biological detecting test piece structure shown by the 12nd figure.Wherein electrode layer 20 can comprise above-mentioned the first metal layer 300 to one or more layers of the 4th metal level 600, and non-conductive glue layer 200.Or rather, electrode layer 20 can comprise the first embodiment except substrate 10 to the electrode structure shown in the 4th embodiment.The bioactivator 30 be arranged on electrode layer 20 may correspond to the biological parameter in detecting.Such as, when the biological parameter that will detect is blood sugar concentration, bioactivator 30 just can comprise glucose oxidase.In certain embodiments, correspond to the biological parameter that will detect, bioactivator 30 can comprise ferment, antigen or antibody.When bioactivator 30 comprises ferment, ferment can comprise glucose oxidase, cholesterol esterase or uricase.
With reference to Figure 13 to Figure 15, it is respectively the chart of the data measured by biological detecting test piece of display Figure 12, shows the chart that the data measured by biological detecting test piece of chart and the display Figure 12 comprising the data measured by biological detecting test piece of carbon/silver (C/Ag) electrode are corresponding with the data measured by blood glucose monitoring system YSI-2300.In the test result of Figure 13 and Figure 15, electrode layer 20 comprises the electrode structure as shown in aforementioned 4th embodiment.
As shown in figure 13, the application of electrode for biological detecting test piece of the present invention has good effect in detection blood sugar concentration.Specifically, as shown in testing result in figure, no matter be that the electrode for biological detecting test piece of the present invention all can provide the testing result with good linear at concentration of glucose high (being greater than 300mg/dl) or concentration of glucose low (being less than 100mg/dl).With reference to Figure 14, its for comprise conventional carbon/silver (C/Ag) electrode biological detecting test piece measured by the chart of data.Relatively after Figure 13 and Figure 14, show the electrode for biological detecting test piece of the present invention relative to traditional biological detecting test piece comprising carbon/silver (C/Ag) electrode, the testing result provided for the electrode of biological detecting test piece of the present invention has consistance, can not have the high glucose concentration that utilizes carbon/silver (C/Ag) electrode detection there will be and the inconsistent situation of low glucose concentrations testing result.Figure 15 then shows the chart corresponding with the data measured by blood glucose monitoring system YSI-2300, and the blood sugar concentration in Figure 15 measured by test paper is the blood sugar concentration applying the electrode for biological detecting test piece of the present invention.At ISO15197; Under the criterion calculation of 2013, electrode for biological detecting test piece of the present invention can have the testing result much smaller than 15% error, and in the error of each blood sugar concentration test point all close to 5% or below 5%, further demonstrate the electrode for biological detecting test piece of the present invention and the good detection result conformed to instrument test result can be provided.
The foregoing is only illustrative, and non-limiting.Anyly do not depart from category of the present invention, and to its equivalent modifications of carrying out or change, all should be contained in the scope of accompanying rights protection.
Description of reference numerals
100,10: substrate
200: non-conductive glue layer
300: the first metal layer
400: the second metal levels
500: the three metal levels
600: the four metal levels
20: electrode layer
30: bioactivator
40: middle partition
50: upper cover
S11, S12, S13, S14, S21, S22, S23, S24, S25, S26, S31, S32, S33, S34, S35, S36, S41, S42, S43, S51, S52, S53, S54, S55, S61, S62, S63, S64, S65, S71, S72, S73, S74, S75: step.
Claims (10)
1., for an electrode for biological detecting test piece, it comprises:
Substrate,
Non-conductive glue layer, it is arranged on described substrate, and
The first metal layer, it is arranged on described non-conductive glue layer;
Wherein said non-conductive glue layer comprises sensitizer and activator.
2., as claimed in claim 1 for the electrode of biological detecting test piece, it is characterized in that, the material of described the first metal layer is palladium.
3., as claimed in claim 1 for the electrode of biological detecting test piece, it is characterized in that, also comprise:
Second metal level, it is arranged on described the first metal layer,
The material of wherein said the first metal layer is palladium, and the material of described second metal level is gold.
4., as claimed in claim 1 for the electrode of biological detecting test piece, it is characterized in that, also comprise:
Second metal level, it is arranged on described the first metal layer, and
3rd metal level, it is arranged on described second metal level;
The material of wherein said the first metal layer is palladium, and the material of described second metal level is nickel, and the material of described 3rd metal level is gold or palladium.
5., as claimed in claim 1 for the electrode of biological detecting test piece, it is characterized in that, also comprise:
Second metal level, it is arranged on described the first metal layer,
3rd metal level, it is arranged on described second metal level, and
4th metal level, it is arranged on described 3rd metal level;
The material of wherein said the first metal layer is copper, and the material of described second metal level is palladium, and the material of described 3rd metal level is nickel, and the material of described 4th metal level is gold or palladium.
6. as claimed in claim 1 for the electrode of biological detecting test piece; it is characterized in that; described sensitizer comprises glucose, diamine, hydroborate, stannous chloride, amino borane compound, aldehydes, hypophosphites or tartrate, and described activator comprises particulate or the compound of nickel, cobalt, palladium, steel or copper.
7., as claimed in claim 1 for the electrode of biological detecting test piece, it is characterized in that, described non-conductive glue layer also comprises bonding agent, and described bonding agent comprises polyvinyl acetate, polyvinyl alcohol (PVA) or isopropyl titanate.
8., as claimed in claim 1 for the electrode of biological detecting test piece, it is characterized in that, described non-conductive glue layer also comprises bonding agent, and described bonding agent comprises acrylate copolymer or alkoxide.
9. manufacture a method for the electrode being used for biological detecting test piece, it comprises:
Substrate is provided;
Form non-conductive glue layer on the substrate, described non-conductive glue layer comprises sensitizer and activator; And
Described non-conductive glue layer is formed one or more layers metal level.
10. the method manufacturing the electrode being used for biological detecting test piece as claimed in claim 9; it is characterized in that; described sensitizer comprises glucose, diamine, hydroborate, stannous chloride, amino borane compound, aldehydes, hypophosphites or tartrate, and described activator comprises particulate or the compound of nickel, cobalt, palladium, steel or copper.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW103129725 | 2014-08-28 | ||
| TW103129725A TW201608237A (en) | 2014-08-28 | 2014-08-28 | Electrode for biosensor and method for manufacturing the same |
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| CN105466985A true CN105466985A (en) | 2016-04-06 |
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| CN201410452430.7A Pending CN105466985A (en) | 2014-08-28 | 2014-09-05 | Electrode for biological detection test piece and manufacturing method thereof |
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| TW (1) | TW201608237A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018210104A1 (en) * | 2017-05-17 | 2018-11-22 | 京东方科技集团股份有限公司 | Bio-detection chip and detection method thereof |
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| WO2009133983A1 (en) * | 2008-04-28 | 2009-11-05 | Keum Pil Lee | Biosensor |
| CN102135519A (en) * | 2009-12-31 | 2011-07-27 | 立威生技实业股份有限公司 | Electrode for biological detection test specimen, manufacturing method thereof and biological detection test specimen thereof |
| CN102455312A (en) * | 2010-10-26 | 2012-05-16 | 佑泰电子股份有限公司 | Electrochemical test piece |
| CN103995030A (en) * | 2010-10-26 | 2014-08-20 | 佑泰电子股份有限公司 | Method for manufacturing electrochemical detection test piece |
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- 2014-08-28 TW TW103129725A patent/TW201608237A/en unknown
- 2014-09-05 CN CN201410452430.7A patent/CN105466985A/en active Pending
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| US5437999A (en) * | 1994-02-22 | 1995-08-01 | Boehringer Mannheim Corporation | Electrochemical sensor |
| WO2009133983A1 (en) * | 2008-04-28 | 2009-11-05 | Keum Pil Lee | Biosensor |
| CN102135519A (en) * | 2009-12-31 | 2011-07-27 | 立威生技实业股份有限公司 | Electrode for biological detection test specimen, manufacturing method thereof and biological detection test specimen thereof |
| CN102455312A (en) * | 2010-10-26 | 2012-05-16 | 佑泰电子股份有限公司 | Electrochemical test piece |
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| WO2018210104A1 (en) * | 2017-05-17 | 2018-11-22 | 京东方科技集团股份有限公司 | Bio-detection chip and detection method thereof |
| US11067570B2 (en) | 2017-05-17 | 2021-07-20 | Beijing Boe Optoelectronics Technology Co., Ltd. | Bio-detection chip and detection method associated therewith |
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| TW201608237A (en) | 2016-03-01 |
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