CN105455869A - Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof - Google Patents
Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof Download PDFInfo
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- CN105455869A CN105455869A CN201510808275.2A CN201510808275A CN105455869A CN 105455869 A CN105455869 A CN 105455869A CN 201510808275 A CN201510808275 A CN 201510808275A CN 105455869 A CN105455869 A CN 105455869A
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- magnesium alloy
- magnesium
- alloy
- hemostatic clamp
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
Abstract
An absorbable magnesium alloy laparoscope hemostatic clip is prepared from V-shaped magnesium alloy. The magnesium alloy is prepared by adding a certain portion of alloying elements including one or more of Zn, Zr, Ca, Mn, Y, Sr and Ag to a pure magnesium matrix. The absorbable magnesium alloy laparoscope hemostatic clip has the advantages that the absorbable magnesium alloy laparoscope hemostatic clip has excellent biodegradability and physical and mechanical properties; the preparation process of the preparation technology is short; by the adoption of a plate extrusion mode, the defect that plastic deformation of magnesium-based alloy is difficult can be overcome through a three-way pressure and stress state, forming machining is easy, and preparation cost is low; through proper heat treatment after plate blanking, residual stress generated in the stamping process and the phenomenon of nonuniformity of the size of recrystallized grains can be obviously eliminated, the ductility and toughness of the hemostatic clip are improved, and the phenomenon that a magnesium-based hemostatic clip fractures when applied is avoided.
Description
Technical field
The invention belongs to biomedical materials field, relate to a kind of Absorbale magnesium alloy peritoneoscope hemostatic clamp and preparation method thereof.
Background technology
Laparoscopic surgery starts from the eighties in last century, and China introduces this Minimally Invasive Surgery in the early 1990s.Operation is more employing hemostatic clamp hemostasis clinically, and operation is relatively easy, and haemostatic effect is better.Comparatively conventional hemostatic clamp material mainly non-degradable metal material hemostatic clamp and degradable macromolecule hemostatic clamp.This two classes hemostatic clamp has use clinically, but all there is some problems.
Titanium alloy hemostatic clamp is the clinical conventional hemostatic clamp of current laparoscopic surgery, although less to human toxicity, it is forever retained in body and Ion release inflammation, interference images can be brought to diagnose and cause the problems such as patients ' psychological burden.Although Absorbable rod macromolecule hemostatic clamp can vivo degradation, the mechanical strength of macromolecular material is not enough, cause Pressure value to hold time limited, and product cost is too high.For above problem, the degradable magnesium base alloy laparoscopic surgery hemostatic clamp that in the biological safety that this project utilizes magnesium alloy good, mechanical property, particularly body, the feature development of corrodible degraded is novel, solve the limitation that this series products at present exists, the research and development of project have important practical significance for physical and mental health after raising surgical quality and operation in patients.
At present about the preparation method of magnesium alloy hemostatic clamp, such as " a kind of Absorbable rod magnesium base composite material hemostatic clamp and preparation method thereof " patent No.: 201310354547.7, the preparation method of employing is the wire drawing of magnesium base composite material rod, cuts band and molding, annealing in process and cleaning.Because magnesium is close-packed hexagonal lattice type, room temperature slip system is few, plastic working difficult forming.When adopting drawing process molding magnesium silk, the deflection of every a time is restricted, and (2 to 3 passages are generally) after the certain passage of drawing, just need intermediate annealing to improve work hardening phenomenon, therefore the process route of hemostatic clamp machining deformation and the process-cycle long, limit the production efficiency of hemostatic clamp product, add the production cost of hemostatic clamp.
Summary of the invention
The object of the invention is to for above-mentioned technical Analysis and existing problems, provide a kind of Absorbale magnesium alloy peritoneoscope hemostatic clamp and preparation method thereof, this kind of forming method is easy to formed machining and preparation cost is low, and the hemostatic clamp prepared has excellent mechanical performance.
Technical scheme of the present invention:
A kind of Absorbale magnesium alloy peritoneoscope hemostatic clamp, for the magnesium alloy be in the shape of the letter V is made, the composition of magnesium alloy is one or more a certain proportion of alloying elements added on pure magnesium matrix in alloy element Zn, Zr, Ca, Mn, Y, Sr and Ag, and in magnesium alloy, the weight percent content of alloying element is Zn1-6%, Ca, 0.2-1%, Mn0.2-1.5%, Zr0.2-1%, Sr0.2-1%, Y0.2-1%, Ag0.5-2%; Hemostatic clamp entirety is in " v " shape structure with arc chord angle, and opening degree is 9.0-10.0mm, and hemostatic clamp cross sectional shape is rectangle, long 1-1.5mm, wide 0.6-1.0mm, inner arc radius is 1-1.20mm, and outer arc radius is 1.8-2mm, v shape both sides extended line angle is 60 °.
A preparation method for described Absorbale magnesium alloy peritoneoscope hemostatic clamp, adopts the preparation of Absorbable rod Mg-based hydrogen storage condensation material, and comprise extruded, the stamping-out molding of magnesium alloy plate, annealing in process, cleaning, step is as follows:
1) the homogenizing annealing 12-240h at 300-420 DEG C of temperature by the high purity magnesium of cross dimensions Φ 60-100mm or magnesium alloy ingot, then on extruder, be squeezed into the magnesium base alloy sheet material of the wide 30-50mm in cross section, high 0.8-1.5mm, extrusion temperature is 250-300 DEG C, and extrusion speed is 0.5mm/s-3.5mm/s;
2) sheet material after above-mentioned extruding is carried out Ageing Treatment, aging temp is 170-180 DEG C, and the time is 24h;
3) magnesium alloy plate after above-mentioned timeliness is stamped into shape and the size of designed hemostatic clamp by diel, press temperature is room temperature;
4) the magnesium alloy hemostatic clamp after above-mentioned molding is carried out annealing in process, annealing temperature is 250 ~ 300 DEG C, and annealing time is 1 ~ 2h, is cooled to room temperature after taking-up;
5) the magnesium alloy hemostatic clamp after annealing in process being put into dehydrated alcohol carries out cleaning until take out oven dry after its any surface finish, obtained Absorbable rod magnesium base alloy hemostatic clamp.
The preparation method of described magnesium alloy ingot is: with the magnesium ingot of purity>=99.95%, zinc granule, Mg-Zr intermediate alloy, Mg-Ca intermediate alloy, Mg-Mn intermediate alloy, Mg-Y intermediate alloy, Mg-Sr intermediate alloy and Mg-Ag intermediate alloy for raw material, in the vacuum drying oven being connected with argon atmosphere or at SF
6volume percent content be the SF of 0.4%
6+ N
2carry out melting under hybrid protection atmosphere, smelting temperature is 700-720 DEG C, adopts the machinery mode of stirring to stir, and after stirring, insulation 5 minutes, then 675-685 DEG C of temperature range, is cast into the magnesium alloy ingot of Φ 60-100mm.
Advantage of the present invention is: this Absorbable rod magnesium base alloy hemostatic clamp has excellent biological degradability and physical and mechanical properties, this preparation technology preparation flow is short, adopt extrusion plate mode, three-dimensional compressive stress state can overcome the shortcoming that magnesium base alloy is difficult to plastic deformation, be easy to formed machining and preparation cost is low, appropriate heat treatment after sheet metal forming, can obviously eliminate the residual stress produced in punching course, the phenomenon that recrystallization crystal particle dimension is uneven, improve the plasticity and toughness of hemostatic clamp, avoid the phenomenon that magnesio hemostatic clamp clamp process interrupt splits.
Accompanying drawing explanation
Fig. 1 is Absorbable rod magnesium base alloy hemostatic clamp structural representation.
Detailed description of the invention
Embodiment:
A kind of Absorbale magnesium alloy peritoneoscope hemostatic clamp, as shown in Figure 1, for the magnesium alloy be in the shape of the letter V is made, the composition of magnesium alloy is Mg-3Zn-0.2Ca, and wherein the content of Zn is the content of 3wt%, Ca is 0.2wt%, and surplus is Mg; Hemostatic clamp entirety is in " v " shape structure with arc chord angle, and opening degree is 9.2mm, and hemostatic clamp cross sectional shape is rectangle, long 1mm, wide 0.69mm, and inner arc radius is 1.20mm, and outer arc radius is 1.89mm, v shape both sides extended line angle is 60 °.
The preparation method of above-mentioned Absorbale magnesium alloy peritoneoscope hemostatic clamp, adopts the preparation of magnesium alloy condensation material, and comprise extruded, the stamping-out molding of magnesium alloy plate, annealing in process, cleaning, step is as follows:
1) prepare magnesium alloy: magnesium alloy composition is Mg-3Zn-0.2Ca, wherein the content of Zn is the content of 3wt%, Ca is 0.2wt%, and surplus is Mg; The preparation method of this magnesium base alloy is: be greater than magnesium ingot, the zinc granule of 99.95% with purity, and the magnesium calcium alloy of calcic 30wt% is raw material, and then stir-melting in the vacuum drying oven being connected with argon atmosphere becomes the magnesium base alloy ingot casting of Φ 60mm by die casting; Magnesium base alloy ingot casting is carried out homogenizing annealing process, and annealing temperature is 400 DEG C, and then annealing time 24 hours is squeezed into the magnesium base alloy sheet material of 40 × 1mm by extruder, extrusion temperature is 300 DEG C, and extrusion speed is 1mm/S;
2) magnesium base alloy after described extruding is carried out artificial aging process, treatment temperature is 170 DEG C, and the processing time is 24 hours;
3) be hemostatic clamp as shown in Figure 1 by the Mg-3Zn-0.2Ca sheet alloy after timeliness by diel stamping-out;
4) above-mentioned Mg-3Zn-0.2Ca alloy hemostatic clamp is carried out annealing in process, annealing temperature is 300 DEG C, and annealing time is 2h, is cooled to room temperature after taking-up;
5) the Mg-3Zn-0.2Ca alloy hemostatic clamp after annealing in process is put into dehydrated alcohol to carry out cleaning until take out oven dry after its any surface finish, Absorbable rod magnesium base alloy peritoneoscope hemostatic clamp can be obtained.
In this embodiment, in magnesium base alloy, Zn element is as important alloying element, has the dual function of solution strengthening and ageing strengthening, can also improve the corrosion resistance of alloy simultaneously; Ca has stronger Grain Refinement Effect, improves the mechanical property of magnesium alloy, and has the effect that reduction texture improves Mg alloy formed ability; Zn and Ca is one of human body main nutrient elements, has good biocompatibility.
Claims (3)
1. an Absorbale magnesium alloy peritoneoscope hemostatic clamp, it is characterized in that: for the magnesium alloy be in the shape of the letter V is made, the composition of magnesium alloy is one or more a certain proportion of alloying elements added on pure magnesium matrix in alloy element Zn, Zr, Ca, Mn, Y, Sr and Ag, and in magnesium alloy, the weight percent content of alloying element is Zn1-6%, Ca, 0.2-1%, Mn0.2-1.5%, Zr0.2-1%, Sr0.2-1%, Y0.2-1%, Ag0.5-2%; Hemostatic clamp entirety is in " v " shape structure with arc chord angle, and opening degree is 9.0-10.0mm, and hemostatic clamp cross sectional shape is rectangle, long 1-1.5mm, wide 0.6-1.0mm, inner arc radius is 1-1.20mm, and outer arc radius is 1.8-2mm, v shape both sides extended line angle is 60 °.
2. the preparation method of an Absorbale magnesium alloy peritoneoscope hemostatic clamp as claimed in claim 1, it is characterized in that: adopt the preparation of Absorbable rod Mg-based hydrogen storage condensation material, comprise extruded, the stamping-out molding of magnesium alloy plate, annealing in process, cleaning, step is as follows:
1) the homogenizing annealing 12-240h at 300-420 DEG C of temperature by the high purity magnesium of cross dimensions Φ 60-100mm or magnesium alloy ingot, then on extruder, be squeezed into the magnesium base alloy sheet material of the wide 30-50mm in cross section, high 0.8-1.5mm, extrusion temperature is 250-300 DEG C, and extrusion speed is 0.5mm/s-3.5mm/s;
2) sheet material after above-mentioned extruding is carried out Ageing Treatment, aging temp is 170-180 DEG C, and the time is 24h;
3) magnesium alloy plate after above-mentioned timeliness is stamped into shape and the size of designed hemostatic clamp by diel, press temperature is room temperature;
4) the magnesium alloy hemostatic clamp after above-mentioned molding is carried out annealing in process, annealing temperature is 250 ~ 300 DEG C, and annealing time is 1 ~ 2h, is cooled to room temperature after taking-up;
5) the magnesium alloy hemostatic clamp after annealing in process being put into dehydrated alcohol carries out cleaning until take out oven dry after its any surface finish, obtained Absorbable rod magnesium base alloy hemostatic clamp.
3. the preparation method of Absorbale magnesium alloy peritoneoscope hemostatic clamp according to claim 2; it is characterized in that: the preparation method of described magnesium alloy ingot is: with the magnesium ingot of purity>=99.95%, zinc granule, Mg-Zr intermediate alloy, Mg-Ca intermediate alloy, Mg-Mn intermediate alloy, Mg-Y intermediate alloy, Mg-Sr intermediate alloy and Mg-Ag intermediate alloy for raw material, in the vacuum drying oven being connected with argon atmosphere or at SF
6volume percent content be the SF of 0.4%
6+ N
2carry out melting under hybrid protection atmosphere, smelting temperature is 700-720 DEG C, adopts the machinery mode of stirring to stir, and after stirring, insulation 5 minutes, then 675-685 DEG C of temperature range, is cast into the magnesium alloy ingot of Φ 60-100mm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510808275.2A CN105455869A (en) | 2015-11-20 | 2015-11-20 | Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510808275.2A CN105455869A (en) | 2015-11-20 | 2015-11-20 | Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof |
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| CN105455869A true CN105455869A (en) | 2016-04-06 |
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| CN201510808275.2A Pending CN105455869A (en) | 2015-11-20 | 2015-11-20 | Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107736906A (en) * | 2017-09-18 | 2018-02-27 | 天津理工大学 | A kind of Absorbale magnesium alloy skin closure nail and preparation method thereof |
| CN108577922A (en) * | 2018-02-26 | 2018-09-28 | 天津理工大学 | A kind of degradable kirsite laparoscope hemostatic clamp and preparation method thereof |
| CN109280828A (en) * | 2018-12-10 | 2019-01-29 | 南京工程学院 | A kind of high-strength degradable implantation instrument composite material and preparation method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060015144A1 (en) * | 2004-07-19 | 2006-01-19 | Vascular Control Systems, Inc. | Uterine artery occlusion staple |
| US20120065654A1 (en) * | 2010-09-15 | 2012-03-15 | Jens-Peter Straehnz | Ligation device and method |
| CN202288387U (en) * | 2011-10-26 | 2012-07-04 | 杭州桐庐尖端内窥镜有限公司 | Tissue closing clip capable of absorbing magnesium alloy |
| CN102988095A (en) * | 2011-09-15 | 2013-03-27 | 富士胶片株式会社 | Clip unit, ligation device using the same, and method for fabricating the clip unit |
| CN103480035A (en) * | 2013-08-15 | 2014-01-01 | 天津理工大学 | Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip |
-
2015
- 2015-11-20 CN CN201510808275.2A patent/CN105455869A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060015144A1 (en) * | 2004-07-19 | 2006-01-19 | Vascular Control Systems, Inc. | Uterine artery occlusion staple |
| US20120065654A1 (en) * | 2010-09-15 | 2012-03-15 | Jens-Peter Straehnz | Ligation device and method |
| CN102988095A (en) * | 2011-09-15 | 2013-03-27 | 富士胶片株式会社 | Clip unit, ligation device using the same, and method for fabricating the clip unit |
| CN202288387U (en) * | 2011-10-26 | 2012-07-04 | 杭州桐庐尖端内窥镜有限公司 | Tissue closing clip capable of absorbing magnesium alloy |
| CN103480035A (en) * | 2013-08-15 | 2014-01-01 | 天津理工大学 | Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107736906A (en) * | 2017-09-18 | 2018-02-27 | 天津理工大学 | A kind of Absorbale magnesium alloy skin closure nail and preparation method thereof |
| CN108577922A (en) * | 2018-02-26 | 2018-09-28 | 天津理工大学 | A kind of degradable kirsite laparoscope hemostatic clamp and preparation method thereof |
| CN109280828A (en) * | 2018-12-10 | 2019-01-29 | 南京工程学院 | A kind of high-strength degradable implantation instrument composite material and preparation method |
| CN109280828B (en) * | 2018-12-10 | 2021-03-02 | 南京工程学院 | High-strength degradable composite material for implanting instrument and preparation method thereof |
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Application publication date: 20160406 |