CN105378478B - A kind of whole blood sample detection method and blood detector - Google Patents
A kind of whole blood sample detection method and blood detector Download PDFInfo
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- CN105378478B CN105378478B CN201480039632.7A CN201480039632A CN105378478B CN 105378478 B CN105378478 B CN 105378478B CN 201480039632 A CN201480039632 A CN 201480039632A CN 105378478 B CN105378478 B CN 105378478B
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- 210000004369 blood Anatomy 0.000 title claims abstract description 189
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- 102100032752 C-reactive protein Human genes 0.000 claims abstract description 82
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- 108010074051 C-Reactive Protein Proteins 0.000 claims abstract description 18
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
Abstract
A kind of method of the blood detector detected for whole blood sample and whole blood sample detection, using same whole blood sample, can quickly complete the blood routine parameter of the whole blood sample and the measurement of c reactive protein parameter on same blood detector.Blood routine measurement module (1) and c reactive protein measurement module (2) combination are on a blood detector, and, c reactive protein measurement module (2) is provided with least two measurement containers (223), so as to improve the measurement efficiency of c reactive protein parameter, the blood routine parameter of multiple whole blood samples and the measurement of c reactive protein parameter can be quickly completed.
Description
Technical field
The application is related to blood testing and analysis field, and in particular to a kind of whole blood sample detection method and blood testing
Instrument, for supporting that unit carries out haemocyte conventional detection using whole blood sample and CRP is detected.
Background technology
Now, often need to obtain the blood routine parameter of patient blood and CRP (C reaction eggs simultaneously in the clinical diagnosis of hospital
The testing result of parameter in vain).
In existing most of blood testing instruments, the blood routine such as blood count, classification detects that the detection with CRP is to make
Carried out with different types of sample on different instruments, blood count, classification are typically using whole blood sample in blood cell point
Carried out in analysis, and CRP is then measured using serum sample on biochemical analysis or Special Protein Analyzer.And due to blood routine and
CRP is clinically usually used in combination, therefore Hospitals at Present needs to gather sample twice or increase blood sampling volume on patient, respectively
Tested on different machines.So caused suffering for patient larger, and need to detect on two machines, checked operation
Trouble.
In order to solve the above problems, it is necessary to develop on one machine using same whole blood sample detection blood routine ginseng
The instrument of number and CRP parameters.Because the measuring method of these parameters is different, it is therefore desirable to which multiple Measurement channels support different parameters
Measurement.
The product of unit is supported at present, whole blood sample can be used to carry out blood routine parameter measurement and CRP parameter measurements, but its
Test speed is slower, highest test speed be only 20 samples/when, it is impossible to meet the requirement to efficiency in clinical examination.
The content of the invention
The application proposes a kind of whole blood sample detection method and blood detector, same sample can be used, same
The measurement of blood routine parameter and CRP parameters is quickly completed on machine.
According to the application's in a first aspect, the application provides a kind of blood detector, including：Blood routine measurement module, C are anti-
Answer protein measurement module, sample collection and distribute module, fluid path support module and control and message processing module；
Blood routine measurement module is used to provide measurement place for allocated sample, and allocated sample is carried out to obtain
Measurement for the purpose of at least one blood routine parameter simultaneously exports measurement result；
C reactive protein measurement module includes：At least two measurements for providing measurement place for allocated sample are held
Device, and at least a set of detection means, at least a set of detection means carry out obtaining C reaction eggs respectively to the sample in measurement container
Measurement for the purpose of white ginseng number simultaneously exports measurement result；
Sample collection is used to gather whole blood sample with distribute module, and the sample of collection is distributed into blood routine measurement module
With c reactive protein measurement module；
Fluid path support module is that sample collection and distribute module and each measurement module provide fluid path and supported；
Control and message processing module are respectively coupled to sample collection and support mould with distribute module, each measurement module and fluid path
Block, for control sample collection and distribute module collecting sample and distribution sample, the conveying of control fluid path support module progress fluid,
Receive the measurement result of each measurement module output and measurement result is handled.
According to the second aspect of the application, the application provides another blood detector, including：Blood routine measurement module, C
Reactive protein measurement module, sample collection and distribute module, fluid path support module and control and message processing module；
Blood routine measurement module is used to provide measurement place for allocated sample, and allocated sample is carried out to obtain
Measurement for the purpose of at least one blood routine parameter simultaneously exports measurement result；
C reactive protein measurement module is used to provide measurement place for allocated sample, to the sample progress that is allocated with
Obtain the measurement for the purpose of c reactive protein parameter and export measurement result, it is logical that c reactive protein measurement module includes multiple measurements
Road, each Measurement channel includes a measurement container；
Sample collection is used to gather whole blood sample with distribute module, and the sample of collection is distributed into blood routine measurement module
With c reactive protein measurement module；
Fluid path support module is that sample collection and distribute module and each measurement module provide fluid path and supported；
Control and message processing module are respectively coupled to sample collection and support mould with distribute module, each measurement module and fluid path
Block, for control sample collection and distribute module collecting sample and distribution sample, the conveying of control fluid path support module progress fluid,
Receive the measurement result of each measurement module output and measurement result is handled.
According to the third aspect of the application, the application provides a kind of method that blood detector is detected to whole blood sample, bag
Include：
Sample collection procedure, sample collection gathers whole blood sample with distribute module；
Sample allocation step, blood routine measurement module and c reactive protein measurement module are distributed to by the sample of collection；Its
In, the sample for distributing to c reactive protein measurement module is assigned to by the c reactive protein measurement module according to preset order in turn
Multiple measurement containers in one；
Blood routine measuring process, blood routine measurement module carries out obtaining at least one blood routine ginseng to allocated sample
Measurement for the purpose of number simultaneously exports measurement result；
C reactive protein measuring process, c reactive protein measurement module carries out obtaining c reactive protein to allocated sample
Measurement for the purpose of parameter simultaneously exports measurement result.
The blood detector provided according to the application, on the one hand, because blood detector is combined with blood routine measurement module
With c reactive protein measurement module so that the measurement of blood routine parameter and CRP parameters can be completed on same machine, it is to avoid
Twice or repeatedly sample collection, mitigate the pain of patient, it also avoid blood routine parameter and CRP parameters must be in different machines
Upper measurement, reduces the trouble of measurement；On the other hand, c reactive protein measurement module is configured with least two measurement containers/multiple
Measurement channel, the measurement efficiency for raising CRP parameters provides possibility；Because the time of measuring of CRP parameters is longer than blood routine ginseng
Several time of measuring, when multiple samples continuously being carried out with this two kinds measurements on unit, the raising of CRP parameter measurement efficiency, energy
Enough effectively improve overall measurement efficiency.
Each passage in the detection method of the blood detector provided according to the application, c reactive protein measurement module is in turn
Measure, eliminate due to the time of measuring of CRP parameters is longer than the time of measuring of blood routine parameter and to whole measurement efficiency
Influence.
Brief description of the drawings
Fig. 1 is a kind of blood detector Fault profile figure disclosed in the embodiment of the present application 1；
Fig. 2 is a kind of blood detector structural principle block diagram disclosed in the embodiment of the present application 1；
Fig. 3 is another structural principle block diagram of the embodiment of the present application 1C reactive protein measurement modules；
Fig. 4 is the continuous measurement strategies schematic diagram of the sample of the embodiment of the present application 1；
Fig. 5 is the sample collection of the embodiment of the present application 1 and distribute module structural representation；
Fig. 6 a and Fig. 6 b are the sample collection of the embodiment of the present application 1 and distribute module segment assignments sample schematic diagram；Wherein,
Fig. 6 a are the sample size schematic diagrames that the embodiment of the present application 1 is disposably gathered；
Fig. 6 b are sample size schematic diagram of the embodiment of the present application 1 after primary distribution；
Fig. 7 is the auto injection module schematic top plan view of the embodiment of the present application 2；
Fig. 8 is the latex reagent memory module configuration simplified schematic diagram of the embodiment of the present application 3；
Fig. 9 is the method flow diagram that the embodiment of the present application 3 is detected to whole blood sample.
Embodiment
In the embodiment of the present application, CRP parameter measurements function and blood routine measurement function are integrated into same blood to examine
Survey on instrument, CRP measurements and blood routine measurement all use whole blood sample, CRP measurements using first whole blood sample and hemolytic agent are mixed,
Then the mode for adding latex reagent is obtained.During using this metering system, the time of measuring of CRP parameters is joined more than blood routine
Several time of measuring, such as, for same sample, blood routine parameter measurement needs 1 minutes, and CRP parameter measurements then need
2 minutes, if waiting CRP parameter measurements after blood routine parameter measurement is completed, necessarily reduce the survey of blood routine parameter
Measure speed.In order to be quickly completed on same machine in the measurement of blood routine parameter and CRP parameters, the embodiment of the present application, C
Reactive protein measurement module includes multiple Measurement channels, and in the continuous measurement process of sample, multiple Measurement channels are by according to pre-
If rotation adds sample and measured.The application is illustrated in particular embodiments below in conjunction with the accompanying drawings.
Embodiment 1：
Fig. 1 and Fig. 2 are refer to, is a kind of structure of blood detector disclosed in the present embodiment.Wherein, Fig. 1 is blood testing
Instrument dimensional structure diagram, Fig. 2 is blood detector structural principle block diagram；Dot-and-dash arrowhead line in Fig. 2 moves towards for electric signal, real
Arrow line moves towards for fluid path.The blood detector includes：Blood routine measurement module 1 (being marked not shown in Fig. 1), c reactive protein
Measurement module (hereinafter also referred to CRP measurement modules) 2, sample collection (are not shown with distribute module 3, fluid path support module 8 in Fig. 1
Go out mark) and control and message processing module 9 (being marked not shown in Fig. 1).Wherein：
Blood routine measurement module 1 is used to provide measurement place for allocated sample, and allocated sample is carried out to obtain
Measurement for the purpose of at least one blood routine parameter and export measurement result.Fig. 1 is refer to, in a kind of specific embodiment,
Blood routine measurement module 1 can need to be further subdivided into each seed measurement module according to measurement：WBC category measurements module 11,
WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13.WBC category measurements module 11 is used to provide to allocated sample
The place of reaction is completed, and measures five classification results for obtaining WBC；WBC/HGB measurement modules 12 are used to complete WBC (white
Blood cell, leucocyte) count and morphological parameters measurement, and have concurrently measurement HGB (hemoglobin, hemoglobin) work(
Energy；RBC/PLT measurement modules 13 are used to complete RBC (red blood cell, red blood cell), PLT (blood platelet, blood
Platelet) count and morphological parameters measurement.It should be noted that above-mentioned each submodule (11,12 and 13) can use existing
Metering system realize, in actual blood routine measurement process, the measurement submodule of other blood routines can also be increased, or subtract
Few some above-mentioned submodules.
C reactive protein measurement module 2 is used to provide measurement place for allocated sample, to the sample progress that is allocated with
Obtain c reactive protein parameter for the purpose of measurement and export measurement result.Sample is assigned to after c reactive protein measurement module 2,
Hemolytic agent first with addition is reacted, and latex reagent is then added in reaction solution, finally by Photoelectric Detection to adding
The reaction solution of latex reagent carries out light transit dose or amount of light scatter detection, and exports measurement result.To be a sample in the application
This offer from reacting, measure measurement result and export the facility of this process and be referred to as a Measurement channel, a Measurement channel
Generally include：It can be achieved to provide the reaction vessel of reacting environment for sample and reagent, can be achieved to provide measurement place for reaction solution
Measurement container, and can realize the reaction solution in measurement container is measured and exports the detection means of measurement result.In tool
When body is realized, reaction vessel and measurement container can also be united two into one, you can, can also as the reacting environment of sample and reagent
It is used as the measurement place of reaction solution.
In the embodiment of the present application, c reactive protein measurement module includes at least two measurement containers and at least a set of detection dress
Put, to realize multiple Measurement channels, each Measurement channel includes a measurement container, and measurement container is used for for allocated sample
Measurement place is provided, detection means carries out the survey for the purpose of obtaining c reactive protein parameter to the sample in measurement container respectively
Measure and export measurement result.Due to being needed reagents such as whole blood sample, hemolytic agent and latex reagents first before c reactive protein measurement
Mix and pass through the reaction of preset time.Therefore in some specific embodiments, c reactive protein measurement module includes at least one
Reaction vessel, at least two measurement containers and at least a set of detection means, reaction vessel and measurement reservoir, for be divided
The sample and reagent matched somebody with somebody provide reacting environment, and sample and reagent reacting to be dispensed is distributed to survey after finishing according to preset order
Measure and c reactive protein measurement is carried out in container.In the specific embodiment having, reaction vessel and detection means are with measuring container one by one
Correspondence, i.e., each Measurement channel includes a reaction vessel, a detection means and a measurement container.In other specific embodiment
In, reaction vessel and/or detection means are not corresponded with measurement container, the number of such as reaction vessel and/or detection means
Amount is less than measurement container, and reaction vessel and/or detection means are shared by multiple Measurement channels.In this case, a measurement is logical
Road includes a measurement container, the reaction vessel shared with other Measurement channels and/or detection means.In some specific implementations in addition
, can also be without reaction vessel in c reactive protein measurement module in example, measurement container not only provided reacting environment but also provided measurement field
Institute.
Sample collection is used to gather whole blood sample with distribute module 3, and the sample of collection is distributed into blood routine measurement mould
Block 1 and c reactive protein measurement module 2.When Measurement channel includes reaction vessel, sample collection will be gathered with distribute module 3
Sample distribute to reaction vessel；When not including reaction vessel in Measurement channel, sample collection and distribute module 3 are by collection
Sample distributes to measurement container.
Fluid path support module 8 is that sample collection and distribute module and each measurement module provide fluid path and supported.In specific implementation
In example, fluid path support module 8 is generally included：Valve, pump, and/or syringe etc., it is main in blood detector to realize conveying sample
Originally, the transportation function such as reagent and discharge waste liquid.
Control and message processing module 9 are respectively coupled to sample collection and supported with distribute module 3, each measurement module and fluid path
Module 8, for controlling sample collection and the collecting sample of distribute module 3 and distribution sample, the progress fluid of control fluid path support module 8
Convey, receive the measurement result of each measurement module output and measurement result is handled.In the present embodiment, at control and information
The sample gathered every time is assigned to blood routine measurement module by reason module control sample collection with distribute module according to predetermined amount
With a Measurement channel of c reactive protein measurement module, the Measurement channel is determined according to default order in turn, so that
One in multiple measurement containers in c reactive protein measurement module sequentially obtains different distribution samples in turn according to default
This.
The measurement of blood routine and c reactive protein parameter is illustrated with a kind of concrete structure of c reactive protein measurement module below
Process.
As shown in figure 1, c reactive protein measurement module includes two Measurement channels 21,22, the Measurement channel of one of them
Composition schematic diagram is as shown in figure 3, mainly include a reaction vessel 221, a sample transport tube road 222, one measurement container 223, one
Detection means, CRP measuring cell waste liquids output mechanism 224, reaction tank waste liquid output mechanism 225, hemolytic agent transport pipeline 226, instead
Answer container 221 to transport pipeline 222 by sample with measurement container 223 controllably to connect, detection means is photoelectric detector, including
In light transmitting terminal 227 and light test side 228, the present embodiment, light transmitting terminal 227 is light source, and measurement container can be irradiated for launching
Light, light test side 228 be photoelectric sensor, the transmitted light for receiving measured container.In the present embodiment, light transmitting terminal
227 and light test side 228 be separately positioned on the relative both sides of measurement container 223.Two Measurement channels can use above-mentioned identical
Structure, it would however also be possible to employ there is no reaction vessel in different structures, such as another Measurement channel, and complete in measurement container
Into the reaction and measurement of sample and reagent.It will be appreciated by those skilled in the art that the scattering of measured container can also be detected
The position of light, light transmitting terminal and light test side can be adjusted as needed.
Its basic functional principle is：Start after measurement, sample is placed in sample position, by sample collection and distribution mould
Block 3 carries out sample absorption, and then sample collection can be moved with the moving parts in distribute module 3 on each measurement module, will
Required sample is respectively allocated in corresponding measurement module, and such as CRP measurement modules 2, WBC category measurements module 11, WBC/HGB are surveyed
Measure module 12 and RBC/PLT measurement modules 13.Each measurement module soon starts the survey of correspondence parameter after sample is allocated
Amount, cleaning can be carried out after measurement is completed and enters holding state, the beginning of measurement next time is waited.
(it is respectively 2 minutes and 1 point because the CRP parameter measurement times of single sample are longer than blood routine parameter time of measuring
Clock), in order to simultaneously measure both parameters when can realize 60 samples/when high test speed, the present embodiment employ CRP measurement
The design that module binary channels is alternately measured.Its concrete principle is：By the first Measurement channels of CRP 21 and the second Measurement channels of CRP 22
The two independent CRP Measurement channels are integrated, and constitute CRP measurement modules 2.When sample is continuously measured, often gather
Sample, is distributed to the sample of collection is rationed to all blood routine measurement module and in turn in CRP measurement modules
A Measurement channel, for each blood routine measurement module, opened after it terminates blood routine measurement of sample
Begin next sample blood routine measurement.For two Measurement channels of c reactive protein measurement module, the CRP of each sample
Measurement be successively in two CRP Measurement channels alternately, two distribution samples CRP measurement process existence times hand over
Folded, this makes it possible to cause each sample after blood routine parameter measurement is completed the CRP of current sample need not be waited to join again
The completion of number measurement can start the blood routine measurement of next sample.Final each sample completes the survey of oneself CRP parameter
After amount, blood routine and CRP parameters are exported simultaneously, whole measurement results of one sample of output per minute are realized, so as to improve
The speed of integrated testability, with reach 60 samples/when high test speed.
It refer to Fig. 4.Assuming that the time that CRP parameter measurements are spent is 2 minutes, the time of blood routine parameter measurement is 1
Minute.In Fig. 4,1~sample of sample 8 be continuous acquisition sample to be measured, 0min represent measure start time, 1min~
9min represents measurement start time elapsed time (min is chronomere, minute).The blood routine parameter measurement of 8 samples
Serial successively in blood routine measurement module 1 to complete, each sample takes 1min.The CRP parameter measurements of 1~sample of sample 8 are then
In CRP Measurement channels 1 and CRP Measurement channels 2 alternately, each sample takes 2min.As shown in figure 3, sample collection with
Distribute module 3 first distributes sample 1 to the first Measurement channels of CRP 21 the CRP parameter measurements for carrying out sample 1, and then, sample is adopted
Collection distributes sample 2 to the second Measurement channels of CRP 22 the CRP parameter measurements for carrying out sample 2 with distribute module 3, then again by sample
Sample 4 is distributed to the second Measurement channels of CRP 22 carry out CRP parameter surveys afterwards by this 3 distribution again to the first Measurement channels of CRP 21
8 samples of collection are distributed to two surveys by amount, by that analogy, sample collection in turn with distribute module 3 according to default order
Measure passage (the first Measurement channels of CRP 21 and the Measurement channels 22 of CRP second).In said process, the blood routine parameter of each sample
To complete to measure earlier than CRP parameters 1min, but all measurement results of the sample are exported together when CRP parameters are completed.One
Denier starts measurement, whole measurement results of first sample (sample 1) be after first sample starts measurement 2min (due to
CRP parameter measurements need time-consuming 2 minutes) output, whole measurement results of a sample are hereafter exported per 1min.Certainly, finally
Whole measurement results of one sample t=1min should be exported after blood routine parameter measurement, and wherein t value is surveyed for CRP parameters
Amount short time consumption subtracts blood routine parameter measurement short time consumption.As can be seen here, if 60 samples are continuously measured, on 60 minutes left sides
The measurement result of right exportable 60 whole samples, measuring speed is about 60 samples/hour.It should be noted that being simply
Be easy to those of ordinary skill in the art to understand technical scheme and for above-mentioned example, it is impossible to regard as technical scheme all in
Hold, for example, the Measurement channel of CRP parameter measurements can also be multiple, blood routine parameter measurement short time consumption and CRP parameter measurements
Short time consumption can also be other time.In an instantiation, sample collection includes travel mechanism and fixation with distribute module 3
Sampling needle in travel mechanism, travel mechanism drives sampling needle to be moved in the horizontal direction with vertical direction.Fig. 5 is refer to, is
Sample collection and a kind of exemplary construction schematic diagram of distribute module 3 in the present embodiment.Sample collection includes with distribute module 3：Gu
Fixed rack 31, X-direction guide rail 32, X-direction transmission device 33, travel(l)ing rest 34, Z-direction guide rail 35, Z-direction transmission mechanism 36,
Sampling needle 37 and swab 38.Wherein, fixed support 31 is connected with the fixed support of detector, certainly, in other embodiments,
Directly it can also be replaced using the fixed support of detector；Travel(l)ing rest 34 passes through X-direction guide rail 32, X-direction running part 33
It is slidably connected with the formation of fixed support 31 so that travel(l)ing rest 34 and part mounted thereto can move shape in X direction
Into travel mechanism, its power comes from X-direction transmission device 33；Sampling needle 37 passes through Z-direction guide rail 35, Z-direction transmission mechanism 36
It is slidably connected with the formation of travel(l)ing rest 34 so that sampling needle 37 can make Z-direction movement relative to travel(l)ing rest 34；The work of swab 38
With to clean the outer wall of sampling needle 37, when sampling needle 37 carries out Z-direction motion, swab 38 passes through fluid path support module 8 and provides liquid
Cleaning sampling needle outer wall simultaneously takes liquid after cleaning away.
Sample collection and the operation principle of distribute module 3 are as follows：
1. sample collection
By the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to sample gettering site 49, passed by Z-direction
Sampling needle 37 is moved down into the test tube of sample gettering site 49 by motivation structure 36.Now, sampling needle 37 can pass through fluid path branch
The default quantitative sample of power absorption for holding the offer of module 8 is stored in inside sampling needle 37, completes sample collection action.
2. cleaned after sample collection
After sample collection is finished, the outside of sampling needle 37 is unavoidably stained with a small amount of sample, when the uphill process of sampling needle 37,
Swab 38 will clean the outer wall of sampling needle 37, it is to avoid outer wall sample causes quantitative influence.
3. sample is distributed
Driven by X-direction transmission device 33, travel(l)ing rest 34 is moved to the top of correspondence measurement module；By Z side
Sampling needle 37 is moved down into measurement module to transmission mechanism 36.After sampling needle needle point reaches measurement module inside, liquid
Road support module 8 provides power, and the sample being stored in inside sampling needle 37 is quantitatively released, is added in measurement module, completes
Sample distribution is acted.
It should be noted that above-mentioned Z-direction is vertical direction, X-direction is one kind of horizontal direction, in other embodiments
In, horizontal direction can also be Y-direction, or X-direction and Y-direction, for example, all increase drive rail in X-direction and Y-direction,
And increase Y-direction transmission device and just can realize the movement of travel mechanism's (such as travel(l)ing rest 34) in the x-direction and the z-direction；For another example,
X-direction transmission device 33 can also be substituted by the tumbler rotated in the horizontal plane.
In a preferred embodiment, each blood routine measurement module 1, c reactive protein measurement module 2 and the edge of sample gettering site 49
The motion track arrangement of the horizontal direction of sampling needle 37.Sample gettering site 49 is preferably provided at the horizontal direction moving rail of sampling needle
The position of the close initiating terminal of mark.
In a preferred embodiment, sample collection gathers a sample with the sample collection of distribute module 3 with distribute module, so
Segment assignments give each blood routine measurement module 1 and c reactive protein measurement module 2 afterwards.Fig. 6 a and Fig. 6 b are refer to, due to blood routine
What the sample size in measurement module 1 and c reactive protein measurement module 2 required for projects measurement was to determine, therefore, sample collection
Sample size required for being measured with distribute module 3 according to each module, disposable collection is finished.Assuming that in a clinical detection
In, blood routine parameter measurement needs to measure two projects (such as WBC classification items and WBC/HGB measure the items), is respectively necessary for sample
The sample size that this amount is V1 and V2, CRP parameter measurement need is V3, then the sample that sample collection is disposably gathered with distribute module 3
This amount is more than or equal to V1+V2+V3, as shown in Figure 6 a.Then, sample collection measures mould with distribute module 3 according to each blood routine
Sample size needed for block 1 and c reactive protein measurement module 2 distributes to each measurement container.Such as, to the measurement of WBC classification items
The sample that one section of amount of container allocation is V1, now sample collection there remains V2+V3 sample with distribute module 3, as shown in Figure 6 b；
Remaining V2+V3 two sections of samples are respectively allocated to WBC/HGB measure the items and CRP parameters by sample collection with distribute module 3
The measurement container of measurement.In other embodiments, the need for according to measure the item, more multistage, or reduction can also be divided into
Hop count.The advantage of distribution sample is in this way, does not need gradually collecting sample to be assigned in each measurement container, passes through
The mode of disposable collecting sample more saves the time relative to the mode of multi collect sample, improves measurement efficiency.More enter
One step, to avoid the sample cross contamination being assigned in different measurement containers, there is the throwing of preset vol between two sections of samples
Abandon sample.Into contact with reagent sample abandon after, this section of sample can be avoided to influence the measurement result of next measurement module,
Ensure that cross pollution is not present in the sample used in two adjacent measurement modules.
When CRP is measured, hemolytic agent transports pipeline under the driving of fluid path support module 8, by hemolytic agent and adds hemolytic agent
Enter in CRP reaction vessels, it is reacted with the blood sample and latex reagent that add later in CRP reaction vessels, is then passed through
Sample transports pipeline and sample is transported in CRP measurement containers, and the detection of light test side is sent by light transmitting terminal and by CRP measurements
Light emitted by container and sample liquid；After reaction vessel and measurement container complete operation, under the driving of fluid path support module,
Waste liquid discharges CRP reaction vessels and CRP respectively by reaction vessel waste liquid output mechanism and measurement container waste liquid output mechanism respectively
Measure container.It is different from the scheme that prior art is conveyed using sampling needle when conveying hemolytic agent into reaction vessel, this implementation
Pipeline is transported using special hemolytic agent in example hemolytic agent is added into reaction vessel, its purpose is to save because sampling needle is drawn
With the time shared by distribution reagent, raising CRP measuring speed, so as to further improve overall test speed.
Each measurement module is cleaned before starting after measurement terminates with next sample measurement.
In other instantiations, multiple Measurement channels can share reaction vessel in c reactive protein measurement module, instead
Answer container to transport pipeline by different samples and controllably connect different measurement containers.Detection means can also be it is shared,
One selectable annular mechanism for example in c reactive protein measurement module is set, and multiple measurement containers are arranged into annular mechanism
One row, can be arranged on annular with only one of which detection means in c reactive protein measurement module by the detection means in this case
In the rotation approach of mechanism, measurement container is rotated with annular mechanism, and detection means is passed through one by one and is stopped for detection, detection dress
Put to stop at its detection zone measurement container in reaction solution detect.
Blood detector disclosed in the present embodiment, by setting multiple Measurement channels, energy in c reactive protein measurement module
Enough when unit carries out haemocyte conventional detection and CRP detections using whole blood sample, effectively utilize wait c reactive protein and measure
Time carries out the haemocyte conventional detection of other samples, so that the measurement of each sample blood routine parameter and c reactive protein measurement
It can cooperate, plan as a whole blood routine parameter measurement and c reactive protein time of measuring, improved measuring speed.
Embodiment 2：
Unlike the present embodiment and above-described embodiment, blood detector disclosed in the present embodiment also includes auto injection mould
Block 4, as shown in figure 1, auto injection module 4 is sample collection and distribute module 3 continuous sample is provided and complete sample load and
Unloading, auto injection module 4 is preferably provided at the front end of blood detector.Fig. 7 is refer to, is that auto injection module overlooks signal
Figure, mainly includes：Rack for test tube conveying mechanism 41, loading position detecting mechanism 42, rack for test tube loader mechanism 43, rack for test tube feel trim actuator
44th, test tube whether there is testing agency 45 and test tube bar code acquisition of information mechanism 46.The course of work is：Rack for test tube transport portion 41 is along X
The rack for test tube for placing test tube is delivered to loading area 410 by direction, after loading position detecting mechanism 42 detects rack for test tube in place,
Rack for test tube loader mechanism 43, which is entered rack for test tube rack for test tube by the test tube position on rack for test tube successively mobile test tube shelf along Y-direction, to be tried
Pipe detecting position 47, sample mix position 48 and sample gettering site 49；When each test tube placement location on rack for test tube reaches test tube inspection
During location 47, test tube, which whether there is testing agency 45, all can detect whether the position has test tube, while test tube bar code acquisition of information mechanism
46 can scan the bar code on test tube；, can be by when the test tube if detecting test tube when the position is moved to 48 samples and mixes position
Mixing module in device completes the mixing of test tube, then when being moved to sample gettering site 49, can be by sample collection and distribution
Module 3 carries out the absorption of sample；When last test tube position of whole rack for test tube removes sample gettering site 49, rack for test tube unloading
Opposite direction push-in unloading area 411 of the mechanism 44 by rack for test tube in X direction, completes the unloading of whole rack for test tube sample.
In summary, the workflow of whole auto injection module 4 is followed successively by：
1. holding test tubes and rack for test tube, start auto injection program；
2. test tube is delivered to loading position with rack for test tube；
3. rack for test tube is loaded, and test tube is moved into test tube detecting position 47, sample successively and mixes position 48 and sample gettering site 49；
4. test tube is detected the presence of in test tube detecting position 47, when having detected test tube, scans the test tube bar code；
5. position 48 is mixed in sample, if there is test tube, carries out sample mixing, otherwise directly move into sample gettering site 49；
6. in sample gettering site 49：If there is test tube, sample absorption is carried out；
If 7. current sample is located at last test tube of current rack for test tube position, rack for test tube is unloaded.
In a kind of specific embodiment, sample gettering site 49 should be preferably provided at the horizontal direction motion track of sampling needle
Initiating terminal.
In a preferred embodiment, the X-direction of auto injection module 4 should be with sample collection and the X-direction of distribute module 3
Unanimously.
Blood detector disclosed in the present embodiment, the automatic of blood detector is improved by increasing auto injection module 4
The management of change degree, more conducively sample (especially number of samples is various), so as to further increase the blood routine of whole blood sample
With the overall measuring speed of CRP parameters.
Embodiment 3：
Unlike the present embodiment and above-described embodiment, blood detector disclosed in the present embodiment is also deposited including latex reagent
Module 5 is stored up, as shown in figure 1, latex reagent memory module 5 is used to provide Cord blood environment for latex reagent, latex reagent is deposited
Storage module 5 is arranged on the position closer to detector edge away from inside of blood detector.By latex reagent memory module 5
The advantage for the position being arranged far from inside detector is, can not only be convenient for changing latex reagent, and changing latex
It during reagent, can avoid user that hand is stretched into instrument internal, reduce risk of the user by biological pollution.
In a preferred embodiment, Fig. 7 is refer to, latex reagent memory module 5 auto injection module 4 can be arranged on
Sample loading area 410 and sample unloading area 411 between, latex reagent and sample is shared sampling needle to facilitate, and simplification is adopted
The shift motion of sample pin.
In a kind of specific embodiment, Fig. 8 is refer to, latex reagent memory module 5 includes：Refrigeration mechanism 51 and Leng Shimen
52。
The inside of refrigeration mechanism 51 has cool room 53, sideways with opening 54, for providing low temperature for latex reagent.
The one side that cold house's door 52 is used at the lateral opening of cool room close on cool room, cold house's door towards cool room is set
It is equipped with latex reagent and places position 50, cold house's door can makes latex reagent placement position expose outside measuring instrument or incite somebody to action under stress
Latex reagent places position and is closed to cool room.
In one embodiment, cold house's door and refrigeration mechanism are split-type structural, and cold house's door passes through push-and-pull and/or upset
Mode away from cool room and can expose outside measuring instrument or outside measuring instrument close to cool room and closing cool room.For example
Cold house's door 52 away from cool room and can expose outside measuring instrument under stress, now, and cold house's door 52 is open mode, from
And be easy to user to contact latex reagent and place position 50；Cold house's door 52 is in the presence of by opposing force close to refrigeration outside measuring instrument
Cool room is simultaneously closed in room, now, and latex reagent is placed position 50 and is located in cool room cavity.
In a preferred embodiment, the blood detector can further include urgent sample and place position 55, urgent sample
This placement position 55 is arranged on the one side of the dorsad cool room of cold house's door 52.Now, urgent sample places the meeting of position 55 prior to latex reagent
The outside that position 50 is exposed to blood detector is placed, the starting point using this design is, in clinical detection, is examined to blood
Survey instrument add urgent sample frequency be higher than add to blood detector/change latex reagent, facilitate tight using this design
The measurement of anxious sample.
Below using continuous two samples (sample 1 and sample 2) and meanwhile measure whole blood sample blood routine parameter and CRP parameters as
Example is illustrated, wherein, WBC category measurements module, WBC/HGB measurement modules and RBC/PLT are included with blood routine measurement module
Exemplified by measurement module, Fig. 9 is refer to, flow is as follows：
Step 1, startup measurement, the auto injection of sample 1 is with mixing.After startup is measured, auto injection module 4 presses embodiment
Workflow described in 2 completes the sample introduction of sample 1, test tube whether there is detection, test tube bar code acquisition of information and sample mixing.
Step 2, sample 1 are drawn.After test tube reaches sample gettering site 49, sample collection passes through X-direction with distribute module 3
Transmission device 33 is driven, and travel mechanism's (for example travel(l)ing rest 34) is moved into sample gettering site 49, passes through Z-direction transmission mechanism
36 are moved down into needed for blood routine parameter and CRP parameter measurements sampling needle 37 in the test tube of sample gettering site 49 once
Sample is drawn into sampling needle 37.Sampling needle rises to elemental height under the driving of Z-direction transmission mechanism 36, while swab 38
Clean the outer wall of sampling needle 37.
CRP hemolytic agents are added in step 3, CRP Measurement channels 1.Fluid path support module 8 provides power, and CRP hemolytic agents are added
Enter in the CRP Measurement channels 1 in c reactive protein measurement module 2.
Step 4,1 point of blood of CRP Measurement channels.Under the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to CRP surveys
The top of passage 1 is measured, sampling needle 37 is moved down into CRP Measurement channels 1 by Z-direction transmission mechanism 36, CRP measurements are added
Required blood sample.Blood sample, which is added after CRP Measurement channels 1, starts sample haemolysis, is that follow-up CRP measurements are ready.Sampling needle
Elemental height is risen under the driving of Z-direction transmission mechanism 36, while swab 38 cleans the outer wall of sampling needle 37.
Step 5, WBC category measurements module point blood.Under the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to WBC
Sampling needle 37, is moved down into WBC category measurements module 11 by the top of category measurement module 11 by Z-direction transmission mechanism 36
Carry out point blood and start WBC category measurements.After complete component blood, sampling needle 37 rises under the driving of Z-direction transmission mechanism 36
Elemental height, while swab 38 cleans the outer wall of sampling needle 37.
Step 6, WBC/HGB measurement module point blood.Under the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to
The top of WBC/HGB measurement modules 12, WBC/HGB measurement modules are moved down into by Z-direction transmission mechanism 36 by sampling needle 37
Blood sample needed for measuring the module and RBC/PLT measurement modules 13 in 12 is distributed to wherein.
Step 7, the sample drawn after being diluted in WBC/HGB measurement modules 12 are distributed to RBC/PLT measurement modules 13.In blood
Sample is completed after dilution, and fluid path support module 8 provides power, and the part of dilution sample of WBC/HGB measurement modules 12 is drawn to sampling
In pin 37.Sampling needle 37 rises to elemental height under the driving of Z-direction transmission mechanism 36, and then X-direction transmission device 33 drives
Dynamic travel(l)ing rest 34 is moved to the top of RBC/PLT measurement modules 13, is moved down sampling needle 37 by Z-direction transmission mechanism 36
Point blood is carried out into RBC/PLT measurement modules 13 and starts RBC and PLT measurements.After complete component blood, sampling needle 37 is passed in Z-direction
Elemental height is risen under the driving of motivation structure 36, while swab 38 cleans the outer wall of sampling needle 37.
Hemolytic agent is added in step 8, WBC/HGB measurement modules 12.Hemolytic agent is added WBC/HGB by fluid path support module 8
In measurement module 12, start WBC and HGB measurements.
Step 9, absorption latex reagent.The driving travel(l)ing rest 34 of X-direction transmission device 33 is moved to latex reagent storage mould
Sampling needle 37, is moved down into latex reagent memory module 5 and tries latex by the top of block 5 by Z-direction transmission mechanism 36
Agent is drawn into sampling needle 37.Sampling needle 37 rises to elemental height under the driving of Z-direction transmission mechanism 36, while swab 38
Clean the outer wall of sampling needle 37.
Step 10, latex reagent add CRP Measurement channels 1.The driving travel(l)ing rest 34 of X-direction transmission device 33 is moved to C
The top of reactive protein measurement module 2, sampling needle 37 is moved down into CRP Measurement channels 1 by Z-direction transmission mechanism 36 will
Latex reagent is added thereto, while starting CRP measurements.
Step 11, cleaning WBC category measurements module 11, WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13.
WBC category measurements module 11, WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13 are completed after each measurement of sample 1, liquid
Reagent is transported in correspondence measurement module and completes cleaning by road support module 8.
Step 12, the auto injection of sample 2 and mixing, sample 2 are drawn.Repeat step 1 and step 2, handle sample 2.
CRP hemolytic agents are added in step 13, CRP Measurement channels 2.Fluid path support module 8 provides power, by CRP hemolytic agents
In the CRP Measurement channels 2 for adding c reactive protein measurement module 2.
Step 14,2 points of blood of CRP Measurement channels.It is logical that the driving travel(l)ing rest 34 of X-direction transmission device 33 is moved to CRP measurements
Sampling needle 37, is moved down into CRP Measurement channels 2 by the top of road 2 by Z-direction transmission mechanism 36, is added needed for CRP measurements
Blood sample.Blood sample, which is added after CRP Measurement channels 2, starts sample haemolysis, is that follow-up CRP measurements are ready.Sampling needle 37 is in Z
Direction transmission mechanism 36 rises to elemental height under driving, while swab 38 cleans the outer wall of sampling needle 37.
Step 15, the measurement of the blood routine of sample 2, absorption latex reagent.Repeat step 5 is to step 9.
Step 16, latex reagent add CRP Measurement channels 2.The driving travel(l)ing rest 34 of X-direction transmission device 33 is moved to C
The top of reactive protein measurement module 2, sampling needle 37 is moved down into CRP Measurement channels 2 by Z-direction transmission mechanism 36 will
Latex reagent is added thereto, while starting CRP measurements.
Step 17, cleaning WBC category measurements module 11, WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13.
Complete after the measurement of the blood routine of sample 2, repeat step 11.
Step 18, cleaning c reactive protein measurement module 2.Because CRP time of measuring is long compared with blood routine time of measuring, waiting
Blood routine to sample 2 is completed after measurement, and the sample 1 in CRP passages 1 completes CRP measurements, and now fluid path support module 8 starts
The cleaning of CRP Measurement channels 1.Pass through 1 minute again, treat that CRP Measurement channels 2 complete the measurement of sample 2, fluid path support module 8 is opened
The cleaning of dynamic CRP Measurement channels 2.
So far, the measurement of the continuous respective whole blood sample blood routine parameter of two samples and CRP parameters is completed.
Use above specific case is illustrated to the application, is only intended to help and is understood the application not to limit
The application.For those of ordinary skill in the art, according to the thought of the application, above-mentioned embodiment can be become
Change.
Claims (19)
1. a kind of blood detector, it is characterised in that including：
Blood routine measurement module, for providing measurement place for allocated sample, to allocated sample progress with obtain to
Measurement for the purpose of a few blood routine parameter simultaneously exports measurement result；
C reactive protein measurement module, for providing measurement place for allocated sample, carries out obtaining to allocated sample
Measurement for the purpose of c reactive protein parameter simultaneously exports measurement result, and it is logical that the c reactive protein measurement module includes multiple measurements
Road, each Measurement channel includes a measurement container；
Sample collection and distribute module, blood routine measurement module and C are distributed to for gathering whole blood sample, and by the sample of collection
Reactive protein measurement module；
Fluid path support module, is that sample collection and distribute module and each measurement module provide fluid path and supported；The fluid path supports mould
Block transports pipeline including hemolytic agent, and hemolytic agent transports pipeline and connected with c reactive protein measurement module；
Control and message processing module, are respectively coupled to sample collection and distribute module, each measurement module and fluid path support module,
For controlling sample collection and distribute module collecting sample and distribution sample, control fluid path support module to carry out fluid conveying, connecing
Receive the measurement result of each measurement module output and measurement result is handled；When sample is continuously measured, at control and information
Manage module control sample collection and gather whole blood sample with distribute module, and the sample of collection is distributed into c reactive protein measurement mould
Receive the Measurement channel of distribution sample in a Measurement channel and blood routine measurement module in block, c reactive protein measurement module
Determined according to default order in turn；Control and message processing module also control fluid path support module to provide power, by haemolysis
Agent transports pipeline by hemolytic agent and added in the Measurement channel for receiving sample, and control sample collection draws breast with distribute module
Glue reagent simultaneously adds latex reagent the Measurement channel for receiving distribution sample, and the control and message processing module are normal in blood
Sample is controlled when the blood routine that rule measurement module terminates current sample is measured and current sample does not complete c reactive protein parameter measurement
This collection starts the collection and distribution of next sample with distribute module, and the sample of collection is distributed into blood routine according to predetermined amount
Another Measurement channel of measurement module and c reactive protein measurement module, makes c reactive protein measurement module at least to two points
Existence time is overlapped in measurement process with sample.
2. blood detector as claimed in claim 1, it is characterised in that each Measurement channel also includes：
One reaction vessel, the reaction vessel and measurement reservoir, for receiving the sample that sample collection is distributed with distribute module
Sheet and latex reagent；
One detection means, the detection means includes light transmitting terminal and light test side, and the smooth transmitting terminal is used to launch and can irradiate
The light of container is measured, the smooth test side is used for the light for receiving measured container.
3. blood detector as claimed in claim 1, it is characterised in that each Measurement channel also includes a detection dress
Put, the detection means includes light transmitting terminal and light test side, and the smooth transmitting terminal, which is used to launch, can irradiate the light of measurement container,
The smooth test side is used for the light for receiving measured container.
4. blood detector as claimed in claim 1, it is characterised in that the c reactive protein measurement module includes two surveys
Passage is measured, two Measurement channels share a reaction vessel, and the reaction vessel is used to receive sample collection and distribute module distribution
Sample and latex reagent, the reaction vessel, which transports pipeline by different samples respectively and controllably connects different measurements, to be held
Device.
5. blood detector as claimed in claim 1, it is characterised in that two Measurement channels share a detection means, described
Detection means includes light transmitting terminal and light test side, and the smooth transmitting terminal, which is used to launch, can irradiate the light of measurement container, the light
Test side is used for the light for receiving measured container.
6. blood detector as claimed in claim 5, it is characterised in that c reactive protein measurement module includes an annular mechanism,
Measurement container is arranged into a row in annular mechanism, and detection means is arranged in the rotation approach of annular mechanism, and measurement container exists
Rotate, and can stop one by one by detection means and for detection under the drive of annular mechanism.
7. blood detector as claimed in claim 1, it is characterised in that also including auto injection module, the auto injection
Module provides continuous sample for sample collection and distribute module automatically and completes sample and loads and unload, the auto injection module
It is arranged on the front end of blood detector.
8. blood detector as claimed in claim 7, it is characterised in that the sample collection includes moving machine with distribute module
Structure and the sampling needle being fixed in travel mechanism, travel mechanism drive sampling needle to be moved in the horizontal direction with vertical direction.
9. blood detector as claimed in claim 8, it is characterised in that each blood routine measurement module, c reactive protein are surveyed
Measure motion track arrangement of the sample gettering site of module and auto injection module along the horizontal direction of sampling needle.
10. blood detector as claimed in claim 1, it is characterised in that also including latex reagent memory module, the latex
Reagent memory module is used to provide Cord blood environment for latex reagent, and the latex reagent memory module is arranged on blood testing
The position closer to detector edge away from inside of instrument.
11. blood detector as claimed in claim 7, it is characterised in that also including latex reagent memory module, the latex
Reagent memory module is used to provide Cord blood environment for latex reagent, and the latex reagent memory module is arranged on auto injection
Between sample loading area and sample the unloading area of module.
12. the blood detector as described in claim 10 or 11, it is characterised in that the latex reagent memory module includes：
Refrigeration mechanism, it is internal with cool room, sideways with opening；
Leng Shimen, sets for closing the one side on cool room, cold house's door towards cool room at the lateral opening of cool room
Be equipped with latex reagent and place position, cold house door can make under stress latex reagent place position expose outside measuring instrument or
Latex reagent placement position is closed to cool room.
13. blood detector as claimed in claim 12, it is characterised in that cold house's door and refrigeration mechanism are split type knot
Structure, cold house's door away from cool room and can be exposed outside measuring instrument or by measuring instrument by way of push-and-pull and/or upset
Outside close cool room simultaneously closes cool room.
14. blood detector as claimed in claim 12, it is characterised in that also place position, urgent sample including urgent sample
Place the one side that position is arranged on cold house's door dorsad cool room.
15. blood detector as claimed in claim 1, it is characterised in that the control and message processing module control sample
Collection is more than or equal to blood routine measurement module with the sample size that distribute module is gathered every time and c reactive protein measurement module is measured
Required sample size, and the sample segmentation of collection is sequentially allocated to a Measurement channel in c reactive protein measurement module
With blood routine measurement module.
16. the method that the blood detector as any one of claim 1-14 is detected to whole blood sample, it is characterised in that
Including：
Sample collection procedure, control sample collection gathers whole blood sample with distribute module；
Fluid path support module is controlled to provide power, hemolytic agent is transported into pipeline by hemolytic agent adds c reactive protein measurement module
The Measurement channel that will receive sample in；
The sample of collection is sequentially allocated and measures mould to c reactive protein by sample allocation step, control sample collection with distribute module
Receive the Measurement channel root of distribution sample in a Measurement channel and blood routine measurement module for block, c reactive protein measurement module
Determined according to default order in turn；Blood routine measuring process, blood routine measurement module carries out obtaining to allocated sample
Measurement for the purpose of at least one blood routine parameter simultaneously exports measurement result；
Control sample collection to draw latex reagent with distribute module, and latex reagent is added to the Measurement channel for receiving sample；
C reactive protein measuring process, c reactive protein measurement module carries out obtaining c reactive protein parameter to allocated sample
For the purpose of measurement and export measurement result；
When the blood routine measurement and current sample for terminating current sample do not complete c reactive protein parameter measurement, control sample is adopted
Collection starts the measurement of next sample with distribute module, repeats the above steps, and the sample of collection is distributed to according to predetermined amount
All blood routine measurement modules and another Measurement channel of c reactive protein measurement module.
17. method as claimed in claim 16, it is characterised in that in sample allocation step, sample collection and distribute module
A sample is gathered, then segment assignments are to blood routine measurement module and c reactive protein measurement module.
18. method as claimed in claim 16, it is characterised in that right before starting after measurement terminates with next sample measurement
Each measurement module is cleaned.
19. method as claimed in claim 16, it is characterised in that the blood routine measurement module includes WBC category measurement moulds
Block, WBC/HGB measurement modules and RBC/PLT measurement modules, for each sample, sample allocation step includes：
The survey that sample collection distributes sample in turn according to preset order and chosen with distribute module into c reactive protein measurement module
Measure and quantitative sample is distributed in container；
Sample collection distributes quantitative sample into WBC category measurement modules with distribute module；
Sample collection distributes quantitative sample into WBC/HGB measurement modules with distribute module；
Sample collection draws the sample after the dilution of WBC/HGB measurement modules with distribute module and is assigned to RBC/PLT measurement modules.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710876252.4A CN107656068B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
| CN202110296868.0A CN113176417B (en) | 2014-07-01 | 2014-07-01 | Method for detecting blood conventional parameters and C-reactive protein parameters in blood sample |
| CN201710877017.9A CN107656085B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/081426 WO2016000216A1 (en) | 2014-07-01 | 2014-07-01 | Whole blood sample testing method and blood tester |
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| CN202110296868.0A Division CN113176417B (en) | 2014-07-01 | 2014-07-01 | Method for detecting blood conventional parameters and C-reactive protein parameters in blood sample |
| CN201710876252.4A Division CN107656068B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
| CN201710877017.9A Division CN107656085B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
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| CN105378478A CN105378478A (en) | 2016-03-02 |
| CN105378478B true CN105378478B (en) | 2017-10-31 |
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| CN201710876252.4A Active CN107656068B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
| CN201710877017.9A Active CN107656085B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
| CN202110296868.0A Active CN113176417B (en) | 2014-07-01 | 2014-07-01 | Method for detecting blood conventional parameters and C-reactive protein parameters in blood sample |
| CN201480039632.7A Active CN105378478B (en) | 2014-07-01 | 2014-07-01 | A kind of whole blood sample detection method and blood detector |
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| CN201710876252.4A Active CN107656068B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
| CN201710877017.9A Active CN107656085B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
| CN202110296868.0A Active CN113176417B (en) | 2014-07-01 | 2014-07-01 | Method for detecting blood conventional parameters and C-reactive protein parameters in blood sample |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108732135A (en) * | 2017-11-20 | 2018-11-02 | 重庆中元汇吉生物技术有限公司 | A kind of blood cell and analysis of protein device |
| CN112151163A (en) * | 2019-06-28 | 2020-12-29 | 深圳迈瑞生物医疗电子股份有限公司 | Method, device and system for setting sample priority |
| CN112881702A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Blood detection device and method and computer storage medium |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105378478A (en) | 2016-03-02 |
| CN113176417A (en) | 2021-07-27 |
| CN113176417B (en) | 2024-04-02 |
| CN107656085A (en) | 2018-02-02 |
| CN107656068A (en) | 2018-02-02 |
| CN107656068B (en) | 2020-06-09 |
| WO2016000216A1 (en) | 2016-01-07 |
| CN107656085B (en) | 2021-04-09 |
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