CN1053469C - 利用△6-去饱和酶生产γ亚麻酸 - Google Patents
利用△6-去饱和酶生产γ亚麻酸 Download PDFInfo
- Publication number
- CN1053469C CN1053469C CN92113085A CN92113085A CN1053469C CN 1053469 C CN1053469 C CN 1053469C CN 92113085 A CN92113085 A CN 92113085A CN 92113085 A CN92113085 A CN 92113085A CN 1053469 C CN1053469 C CN 1053469C
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- Prior art keywords
- nucleic acid
- desaturase
- bacterium
- acid
- seq
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19003—Linoleoyl-CoA desaturase (1.14.19.3)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Abstract
Description
来源 | 18∶0 18∶1 18∶2 γ18∶3 α18∶3 18∶4 |
鱼腥藻属菌(野生型)鱼腥藻属菌+ORF1(F)鱼腥藻属菌+ORF1(R)鱼腥藻属菌+ORF2(F)鱼腥藻属菌+ORF2(R)集胞藻属菌(野生型) | + + + - + -+ + + - + -+ + + - + -+ + + + + ++ + + - + -+ + + + - - |
菌株 | 脂肪酸 | |||||
18∶0 | 18∶1 | 18∶2 | 18∶3(α) | 18∶3(γ) | 18∶4 | |
野生型集胞藻属菌(PCC 6803)鱼腥藻属菌(PCC 7120)聚胞藻属(蓝藻)(PCC 7942)鱼腥藻属菌转结合体cSy75cSy75-3.5pAM542-1.8FpAM542-1.8RpAM542-1.7FpAM542-1.7R聚胞藻属菌转结合体pAM854pAM854-Δ12pAM854-Δ6pAM854-Δ6和Δ12 | 13.62.920.63.84.34.27.72.82.827.84.018.242.7 | 4.524.879.424.427.613.923.127.825.472.243.281.825.3 | 54.537.1-22.318.112.138.436.142.3-46.0-19.5 | -35.2-9.13.219.130.833.329.6---- | 27.3--27.940.425.4------16.5 | ---12.56.425.4------- |
Claims (13)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US774,475 | 1977-03-04 | ||
US77447591A | 1991-10-10 | 1991-10-10 | |
US81791992A | 1992-01-08 | 1992-01-08 | |
US817,919 | 1992-01-08 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97104566A Division CN1121499C (zh) | 1991-10-10 | 1997-03-21 | 诱导产生十八碳四烯酸的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1072722A CN1072722A (zh) | 1993-06-02 |
CN1053469C true CN1053469C (zh) | 2000-06-14 |
Family
ID=27118889
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN92113085A Expired - Lifetime CN1053469C (zh) | 1991-10-10 | 1992-10-10 | 利用△6-去饱和酶生产γ亚麻酸 |
CN97104566A Expired - Lifetime CN1121499C (zh) | 1991-10-10 | 1997-03-21 | 诱导产生十八碳四烯酸的方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97104566A Expired - Lifetime CN1121499C (zh) | 1991-10-10 | 1997-03-21 | 诱导产生十八碳四烯酸的方法 |
Country Status (23)
Country | Link |
---|---|
US (3) | US5552306A (zh) |
EP (1) | EP0666918B1 (zh) |
JP (1) | JP3537434B2 (zh) |
KR (1) | KR100316068B1 (zh) |
CN (2) | CN1053469C (zh) |
AT (1) | ATE284961T1 (zh) |
AU (1) | AU667848B2 (zh) |
BG (1) | BG61791B1 (zh) |
BR (1) | BR9206613A (zh) |
CA (1) | CA2120629C (zh) |
CZ (1) | CZ285471B6 (zh) |
DE (1) | DE69233459T2 (zh) |
DK (1) | DK0666918T3 (zh) |
ES (1) | ES2231767T3 (zh) |
HU (1) | HU217328B (zh) |
IL (1) | IL103407A (zh) |
MX (1) | MX9205820A (zh) |
NZ (1) | NZ244685A (zh) |
PH (1) | PH31293A (zh) |
RO (1) | RO113256B1 (zh) |
RU (1) | RU2152996C2 (zh) |
UA (1) | UA43314C2 (zh) |
WO (1) | WO1993006712A1 (zh) |
Families Citing this family (119)
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US6872872B1 (en) | 1992-11-17 | 2005-03-29 | E. I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants |
US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
CA2150133A1 (en) * | 1993-02-05 | 1994-08-18 | Vincent Jean-Marie Armel Arondel | Altered linolenic and linoleic acid content in plants |
US5639645A (en) * | 1993-09-22 | 1997-06-17 | Mitsubishi Corporation | Recombinant Δ9 desaturase and a gene encoding the same |
US6310194B1 (en) * | 1994-09-26 | 2001-10-30 | Carnegie Institution Of Washington | Plant fatty acid hydroxylases |
US5965793A (en) | 1995-09-20 | 1999-10-12 | Monsanto Company, Inc. | Strong early seed-specific gene regulatory region |
US5959175A (en) * | 1997-04-09 | 1999-09-28 | Thomas; Terry L. | Sunflower albumin 5' regulatory region for the modification of plant seed lipid composition |
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US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
US7745694B1 (en) | 1997-04-11 | 2010-06-29 | Monsanto Technology Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
US6075183A (en) * | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
US6080911A (en) * | 1997-04-15 | 2000-06-27 | Ohio University | Mice models of growth hormone insensitivity |
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US6100450A (en) * | 1997-10-22 | 2000-08-08 | Rhone-Poulenc Agrochimie | Seed specific promoters based on arabidopsis genes |
AU4544799A (en) * | 1998-05-29 | 1999-12-13 | Ohio University | Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products |
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