A kind of near-infrared light therapy device for treating alzheimer disease
Technical field
The invention belongs to technical field of medical instruments, it is related to a kind of near-infrared light therapy device, more particularly, to one kind
Near-infrared light therapy device for treating alzheimer disease.
Background technology
Alzheimer disease (Alzheimer ' s disease, AD) is commonly called as senile dementia, is a kind of common neural work(
Energy disorder disease, its Development process is slow and constantly deteriorates over time, and early symptom is that short-term memory occur to be damaged.With disease
The development of disease, it may appear that linguistic function obstacle, emotional instability, be difficult to take care of oneself and abnormal behavior etc., finally loses physical function
And cause death.The origin cause of formation of alzheimer disease still fails to understand, from the current study, the sick possible factor and vacation so far
Say kind up to more than 30.Medically think, the process of the disease mainly may have with kind of starch sample protein plaque deposition in brain
Close.Alzheimer disease there are about 6% incidence of disease in over-65s old man, also have some patientss just to be fallen ill before 65 years old.
With the extension and the aggravation of aging population of the average life span, alzheimer patient is constantly increasing in the whole world and China
It is many, and bring huge burden on society and financial burden.
At present, clinically existing treatment method is mainly attempt to delay disease process alzheimer disease, controls curative effect
Really limited, also not any medicine is proved to prevent completely the development of alzheimer disease, can not reverse.It is existing
Medicine, such as cholinesterase antagonist and nmda receptor antagonist, there is larger side effect, and these medicines come to patient
Say, in some instances it may even be possible to the extent of damage of its cognitive function can be aggravated.At this stage, in the world also have some in research and development for A Er
The medicine of variant protein matter in patient's Zi Haimo cranial nerve cell, sees some effects on experiment mouse, but human trial into
The case of work(does not have been reported that.
In recent years, start the method for using physical factor treatment alzheimer disease occur both at home and abroad, for example, near infrared light
Treat, treated through cranium electricity treatment, through cranium magnetic etc..However, cerebral cortex can only be reached through cranium electricity and through the effect of stimulation of cranium magnetic, and
Deep brain area involved by some functional networks, such as prefrontal lobe inner side, island leaf, cingulate gyrus position, it is impossible to further relate to
And.Wherein, repeated transcranial magnetic stimulation has the possibility for triggering epilepsy, and this can cause potentially hazardous to human body.And it is near red
Outer photoradiation treatment is likely to become a kind of effective ways of effective treatment alzheimer disease.
It is reported that also having been carried out using the human clinical trial of near-infrared light exposure treatment alzheimer disease.However, existing
Some zooperies or human trial, the main equipment that uses is portable equipment or homemade equipment, these equipment
The control of test parameters is extremely difficult.The power density (luminous power in unit area) that especially near infrared light shines is to controlling curative effect
Fruit has very big influence.Existing therapeutic equipment is very simple home-built equipment, it is impossible to adjust light according to head size
The distance between source and head, this will cause the power density distribution that near infrared light shines uneven and cannot adjust, so as to influence most
Whole therapeutic effect, at the same time, it is also possible to cause local optical power density to exceed the safety value upper limit of Medical Instruments.Separately
Outward, the report of nearest multinomial zoopery shows that the difference of illumination methods, such as light application time, pulsed light shine, also can be to reality
Test result and produce influence.
Regarding to the issue above, today there is also many linguistic term to near-infrared light therapeutic apparatus.For example, Application No.
201410450333.4 Chinese invention patent discloses a kind of near-infrared light therapeutic apparatus for treating cerebral disease, including can send out
Light source, the carrier of light source of near infrared light are penetrated, the hemisphere face support of immobilization carrier drives the driver of the light source luminescent, uses
In human-computer interaction module and power supply that the signal controller to driver offer control light source, the information input of whole system are defeated
Module, the human-computer interaction module is connected with the input of controller, and the output end of controller is connected with the input of driver,
The output end of driver is connected with light source, and the power module is connected with driver, controller, human-computer interaction module;The light
Source range of exposures covers whole forehead, and lower neat brow ridge wraps temple, the crown, the back side of head, lower neat neck upper limb, the light source
Wave-length coverage be 600nm-900nm.In this wave-length coverage, near infrared light is to make mitochondria and related enzyme activity according to one side
Raise, cause series reaction to repair injured neurons;On the other hand, it is right by strengthening the Hemodynamics of specific region
The brain diseases such as children's hyperkinetic syndrome, apoplexy and menopausal syndrome work.Because the pathogenesis of different brain diseases is different,
There is no assurance that having good therapeutic effect to alzheimer disease in this wave-length coverage.And of the present invention
In the range of 900nm-2550nm, especially on specific wavelength such as 935-955nm, 1065-1095nm and 1230-1280nm,
Near infrared light is according to the main reason that can effectively reduce alzheimer disease --- the generation of amyloid protein precipitation, while improving
The release of specific neurotransmitter, effectively alleviates and reverse disease process.
The content of the invention
The purpose of the present invention is exactly that a kind of simple structure, tight is provided for the defect for overcoming above-mentioned prior art to exist
Gather, the distance between light source and head can be automatically adjusted according to head size, and the use of illumination parameter and illumination methods can be adjusted
In the near-infrared light therapy device for the treatment of alzheimer disease.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of near-infrared light therapy device for treating alzheimer disease, the device includes cabinet, is arranged on machine
Lever arm on case and be arranged on lever arm one end wear mechanism, this is worn mechanism and can be set up or down by lever arm
Put on cabinet, human-computer interaction interface and power switch are additionally provided with described cabinet, described device also includes being arranged on head
Wear in-house near infrared light mechanism and be arranged on the near infrared light control unit of cabinet inside, described is near
Infrared irradiation mechanism is arranged on and wears in-house and described near infrared light photograph with drawing in by connecting element expansible
Mechanism is penetrated to be electrically connected near infrared light control unit by circuit;
During treatment, illumination mode, light application time and intensity of illumination parameter are set by human-computer interaction interface, according to patient
Head size, is moved up and down by lever arm and wears mechanism, is made to wear mechanism and is covered patients head completely, then regulating near-infrared
The distance between light irradiating means and patients head, subsequent near infrared light control unit is according to default illumination mode, light
According to time and intensity of illumination parameter, control near infrared light mechanism carries out near infrared light treatment to patients head.
The described mechanism that wears includes head-shield shell, the projection being arranged on head-shield outer casing bottom edge and is arranged on head
Transom on cover shell.
Described near infrared light mechanism includes being arranged on the polygonized structure plate on head-shield enclosure top and many
The individual module faceplate being hinged with polygonized structure plate respectively by connecting element, on described polygonized structure plate and module faceplate
It is respectively equipped with near-infrared luminous diode array, and is additionally provided with for preventing on described polygonized structure plate and module faceplate
Patient's scalp contacts the translucent cover of near-infrared luminous diode array.
Described module faceplate is module faceplate from top to bottom gradually wide and with spheric curvature, and the back side of module faceplate sets
There is radiator fan.
Near-infrared luminous diode array on described module faceplate from top to bottom uniformly launches to set in divergent shape.
Described module faceplate is provided with 3-12 altogether, and number and the polygonized structure plate of described module faceplate side
Number it is equal, in working order under, near infrared light control unit controls modules face according to parameter preset at the same time or separately
The irradiation of near-infrared luminous diode array on plate.
During actual therapeutic, near-infrared on modules panel can be respectively set according to the actual conditions of patient
The illumination parameter of near-infrared luminous diode array can be respectively on the illumination parameter of light emitting diode matrix, i.e. modules panel
Control, it is also possible to while the illumination parameter of near-infrared luminous diode array on modules panel is set as into identical parameters
Value.
Described projection includes being used for first projection of shade eye and for shade patients head's hindbrain a pair
It is second raised, and described first is raised and the second projection on further respectively have near-infrared luminous diode array,
Wherein, the first described projection is hinged with the module faceplate of relevant position by connecting element.
Described connecting element is Damping rotation shaft.
Specifically, described module faceplate is connected by Damping rotation shaft with polygonized structure plate, and will be hindered by screw hole
The subsidiary pad of Buddhist nun's rotating shaft is fixed on polygonized structure plate, and Damping rotation shaft can ensure the module faces around polygonized structure plate
Plate rotates along axle, and can be fixed on suitable position and remain stationary as.
The a length of 900-2550nm of near-infrared light waves of described near-infrared luminous diode array transmitting.
Programming device and timing buzzer, described Programmable are provided with described near infrared light control unit
Part is electrically connected with human-computer interaction interface, near infrared light mechanism and timing buzzer respectively by circuit.
In actual design process, it is provided with described near infrared light control unit and is used cooperatively with programming device
Peripheral circuit, the peripheral circuit includes that dc source, timing sounding electric circuit, display circuit, transforming circuit and signal occur
Circuit.
Specifically, described programming device by transforming circuit, timing sounding electric circuit, display circuit respectively with direct current
The connection of source, timing buzzer and human-computer interaction interface, and described programming device will be default by signal generating circuit
Illumination mode, light application time and intensity of illumination parameter are sent near infrared light mechanism, and control near infrared light machine
The working condition of structure.
In the present invention, described human-computer interaction interface may be selected from touch display screen, and it can be used not only for setting different photographs
Penetrate parameter and be irradiated treatment, radiation parameters can also be shown, be conducive to the interactivity of operating personnel and device;Described cabinet
Bottom is additionally provided with universal wheel, is moved easily therapeutic system.
Described illumination mode is divided into continuous illumination and penetrates and pulse light irradiation.
Compared with prior art, the invention has the characteristics that:
1) it is rotatably arranged in due to the module faceplate of near-infrared luminous diode array will be provided with using Damping rotation shaft
On polygonized structure plate, while the first projection is connected with the module faceplate of correspondence position also by Damping rotation shaft, can realize opening
Open the action feature of gathering, be conducive to conveniently and efficiently between regulating near-infrared light emitting diode matrix and patients head between
Away from, different size of patients head is can be suitably used for, it is applied widely;
2) due to using near infrared light control unit, and human-computer interaction interface is combined, it is possible to achieve near infrared light shines
The quick and precisely setting of illumination mode, light application time and the intensity of illumination parameter of mechanism is penetrated, and near infrared light control
Under the regulation of unit processed, intelligentized control method can be realized near infrared light mechanism, while convenient operation, effectively eliminated
The uneven technical problem of near infrared light shines in the prior art power density distribution, substantially increases near infrared light treatment
Effect;
3) overall structure is simple, compact, simple operation, and man-machine interaction is good, can realize intelligentized control method, effectively improves near
The security and validity of Infrared irradiation treatment, with good application prospect.
Brief description of the drawings
Fig. 1 is overall structure diagram of the present invention;
Fig. 2 wears mechanism's structural representation for the present invention;
Fig. 3 is module faceplate positive structure schematic of the present invention;
Fig. 4 is module faceplate reverse structure schematic of the present invention.
Description of symbols in figure:
1st, head-shield shell, 2, transom, 3, lever arm, 4, human-computer interaction interface, 5, power switch, 6, cabinet, 7, universal
Wheel, 8, near-infrared luminous diode array, 9, module faceplate, 10, polygonized structure plate, 11, first is raised, and 12, Damping rotation shaft,
13rd, second is raised, and 14, translucent cover, 15, screw hole, 16, pad, 17, fan.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below the present invention in technical scheme carry out clearly
Chu, it is fully described by, it is clear that described embodiment is a part of embodiment of the invention, rather than whole embodiments.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
Embodiment 1:
As shown in figure 1, a kind of near-infrared light therapy device for treating alzheimer disease, the device includes cabinet
6th, the lever arm 3 that is arranged on cabinet 6 and be arranged on the one end of lever arm 3 wear mechanism, this wears mechanism by lever arm 3
Can up or down be arranged on cabinet 6, human-computer interaction interface 4 and power switch 5 are additionally provided with cabinet 6, device also includes setting
Put in the near infrared light control unit for wearing in-house near infrared light mechanism and be arranged on inside cabinet 6,
Near infrared light mechanism is arranged on and wears in-house, and near infrared light machine with drawing in by connecting element expansible
Structure is electrically connected by circuit near infrared light control unit.
Before treatment, errorless rear power-on switch 5 is checked.During treatment, by human-computer interaction interface 4 set illumination mode,
Light application time and intensity of illumination parameter, according to patients head's size, are moved up and down by lever arm 3 and wear mechanism, make to wear
The distance between mechanism covers patients head completely, then regulating near-infrared light irradiating means and patients head, subsequent near-infrared
Light irradiation control unit controls near infrared light machine according to default illumination mode, light application time and intensity of illumination parameter
Structure carries out near infrared light treatment to patients head.
As shown in Fig. 2 wearing mechanism including head-shield shell 1, the projection being arranged on the bottom margin of head-shield shell 1 and setting
Put the transom 2 on head-shield shell 1, it is ensured that radiating is good.
Near infrared light mechanism includes being arranged on that the polygonized structure plate 10 and multiple of the inner tip of head-shield shell 1 are logical
The module faceplate 9 that connecting element is hinged with polygonized structure plate 10 respectively is crossed, is distinguished on polygonized structure plate 10 and module faceplate 9
Near-infrared luminous diode array 8 is provided with, translucent cover 14 is coated with polygonized structure plate 10 and module faceplate 9, to prevent people
Skin of head contacts near-infrared luminous diode lamp bead and do harm to huamn body.
Projection includes being used for for a pair the first raised 11 of shade eye and for shade patients head's hindbrain the
Two projections 13, and near-infrared luminous diode array 8 is further respectively had in the first raised 11 and second projection 13, its
In, first raised 11 is hinged with the module faceplate 9 of relevant position by connecting element.
As shown in figure 3, module faceplate 9 is module faceplate 9 from top to bottom gradually wide and with spheric curvature, module faceplate 9
The back side be provided with radiator fan 17.Near-infrared luminous diode array 8 on module faceplate 9 is from top to bottom uniformly opened up in divergent shape
Open up and put.
Under in working order, near infrared light control unit is controlled at the same time or separately according to parameters such as default intensities of illumination
The irradiation of the near-infrared luminous diode on modules panel 9 processed.
During actual therapeutic, near-infrared on modules panel 9 can be respectively set according to the actual conditions of patient
The illumination parameter of near-infrared luminous diode array 8 can on the illumination parameter of light emitting diode matrix 8, i.e. modules panel 9
Control respectively, it is also possible to while the illumination parameter of near-infrared luminous diode array 8 on modules panel 9 is set as identical
Parameter value.
In the present embodiment, near-infrared luminous diode in working order under, the near-infrared wavelength of transmitting is concentrated mainly on
900-2550nm, it may be preferred to specific wavelength, such as 935-955nm, 1065-1095nm and 1230-1280nm.Illumination mode point
For continuous illumination is penetrated and pulse light irradiation.The side number of polygonized structure plate 10 is 8, number and the polygon knot of module faceplate 9
The side number of structure plate 10 is identical, and 8 are provided with altogether.
In the design process, connecting element use Damping rotation shaft 12, specifically, module faceplate 9 by Damping rotation shaft 12 with
Polygonized structure plate 10 is connected, and the subsidiary pad 16 of Damping rotation shaft 12 is fixed on into polygonized structure plate 10 by screw hole 15
On, Damping rotation shaft 12 can ensure that the module faceplate 9 around polygonized structure plate 10 rotates along axle, and can be fixed on suitably
Position and remain stationary as, first raised 11 is connected in this way with the module faceplate 9 of correspondence position.
Be provided with programming device near infrared light control unit, the programming device by circuit respectively with man-machine friendship
Mutual interface 4, the electrical connection of near infrared light mechanism.
Timing buzzer is additionally provided near infrared light control unit, the timing buzzer passes through circuit and Programmable
Part is electrically connected.In actual design process, it is provided with outer with what programming device was used cooperatively near infrared light control unit
Circuit is enclosed, the peripheral circuit includes dc source, timing sounding electric circuit, display circuit, transforming circuit and signal generating circuit.
Specifically, programming device by transforming circuit, timing sounding electric circuit, display circuit respectively with dc source, timing buzzer
And human-computer interaction interface 4 is connected, and programming device by signal generating circuit by default illumination mode, light application time with
And intensity of illumination parameter is sent near infrared light mechanism, and control the working condition of near infrared light mechanism.
Human-computer interaction interface 4 may be selected from touch display screen, and it can be used not only for the different radiation parameters of setting and is irradiated
Treatment, can also show radiation parameters, be conducive to the interactivity of operating personnel and device;The bottom of cabinet 6 is additionally provided with universal wheel 7,
It is moved easily therapeutic system.
During treatment, 5 are first turned on the power switch, radiation parameters are set in touch display screen, when such as irradiating light intensity, irradiation
Between, irradiation mode.According to the different demands of therapeutic scheme, irradiation mode may be configured as continuous illumination penetrate with pulse light irradiation, separately
Outward, the irradiation of near-infrared luminous diode array 8 light intensity in the region of disparate modules panel 9 can be respectively provided with.Radiation parameters can also be pressed
It is operated according to pattern set in advance, such as factory mode.Can be shown in touch display screen after parameter setting is good, together
When corresponding order data be sent to programming device, programming device can be selected from single-chip microcomputer, and the single-chip microcomputer send and correspondingly refer to
Order is controlled to peripheral circuit, near infrared light mechanism is operated according to the radiation parameters for setting.During treatment, the number of people
Portion is placed in head-shield shell 1, and regulation lever arm 3 makes head-shield shell 1 just cover on head part, adjusts each according to head part's size
Module faceplate 9 and the relative distance of head part, make one scalp and keep suitable with the near-infrared luminous diode array 8 of corresponding position
Suitable irradiation distance.At the end of to be treated, timing buzzer can send ring, remind operating personnel to cut off the electricity supply.
Embodiment 2:
In the present embodiment, the side number of polygonized structure plate 10 is 3, number and the polygonized structure plate 10 of module faceplate 9
Side number it is identical, 3 are provided with altogether.Remaining is with embodiment 1.
Embodiment 3:
In the present embodiment, the side number of polygonized structure plate 10 is 6, number and the polygonized structure plate 10 of module faceplate 9
Side number it is identical, 6 are provided with altogether.Remaining is with embodiment 1.
Embodiment 4:
In the present embodiment, the side number of polygonized structure plate 10 is 10, number and the polygonized structure plate 10 of module faceplate 9
Side number it is identical, 10 are provided with altogether.Remaining is with embodiment 1.
Embodiment 5:
In the present embodiment, the side number of polygonized structure plate 10 is 12, number and the polygonized structure plate 10 of module faceplate 9
Side number it is identical, 12 are provided with altogether.Remaining is with embodiment 1.
Finally it should be noted that:The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations;Although
The present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those within the art that:It still may be used
Modified with to the technical scheme described in foregoing embodiments, or equivalent is carried out to which part technical characteristic;
And these modification or replace, do not make appropriate technical solution essence depart from various embodiments of the present invention technical scheme spirit and
Scope.