CN105126237A - Double-mode heart in-situ perfusion system - Google Patents
Double-mode heart in-situ perfusion system Download PDFInfo
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- CN105126237A CN105126237A CN201510363454.XA CN201510363454A CN105126237A CN 105126237 A CN105126237 A CN 105126237A CN 201510363454 A CN201510363454 A CN 201510363454A CN 105126237 A CN105126237 A CN 105126237A
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Abstract
The invention discloses a double-mode heart in-situ perfusion system and belongs to the technical field of medical instruments. The system comprises a perfusion guide pipe, an infusion connecting pipe, a pressure sensor, a hydraulic pump, a physiological recorder and a signal discriminator. The tail ends of two inner pipes in a straight section portion of the perfusion guide pipe are connected with the hydraulic pump and the pressure sensor through the infusion connecting pipe respectively, the inner pipe with the tail end closed and the lateral side open is communicated with a pump outlet of the hydraulic pump, the inner pipe with the tail end open is communicated with the pressure sensor, the pressure sensor transmits measured pressure signals to the signal discriminator, the physiological recorder transmits human electrocardiograph signals to the signal discriminator, and the signal discriminator processes the electrocardiograph signals or the pressure signals and then sends a starting or stopping signal to the hydraulic pump to control perfusion time. The double-mode heart in-situ perfusion system can realize long-time perfusion of cell factors or stem cells and has the advantages of safety, easiness in operation and high targeting ability, and treatment effect of ischemic heart failure is improved.
Description
Technical field
The present invention relates to a kind of filling system realizing administration for ischemic heart desease, be specifically related to a kind of double mode heart in-situ perfusion system, belong to technical field of medical instruments.
Background technology
Ischemic heart desease is the common disease of serious threat human health.Current conventional therapy offer limited effectiveness, stem cell transplantation, cytokine infusion of therapeutic ischemic heart desease demonstrate huge potentiality, but need to play therapeutical effect in position, avoid periphery non-target tissue to absorb and utilize.
Traditional heart delivery mode comprises intracoronary injection, injection transplantation and through intravenous injection in intramyocardial injection, Epicardium.
● injection transplantation in subendocardiac muscle: by endocardium Electrophysiological mapping determination cardiac infarct sites, scope, by injection catheter infarction tissue surrounding injection stem cell, there is the feature of accurate positioning, but operating process is complicated, consuming time, skills involved in the labour require high, and apparatus expensive, the application of restriction the method.
● injection transplantation in Epicardium: usually carry out while the open chest surgery such as bypass operation of coronary artery or prosthetic valve replacement, the method accurate positioning, be convenient to quantize and late detection, but due to needs open chest surgery, accommodator is less.
● through vein transplantation: be stem cell transplantation method the most simply and easily, but transplanted cells cytokine needs through systemic circulation, great majority are arrested in pulmonary and liver, only a small amount of cell can arrive cardiac muscular tissue, so transplant inefficiency; Cytokine is then degraded and is utilized by surrounding tissue picked-up, and target tissue effective dose is low, easily causes side effect.
● intracoronary injection is transplanted: be the most frequently used injection transplantation technology, adopt the method for percutaneous coronary intervention (pci), guide through guiding catheter and coronary guide wire, be encapsulated the coronary artery closing selection by microtubular or microsphere, utilize pressure by stem cell, cytokine infusion, reduce and overflow; For avoiding conduit or the long-time indwelling of sacculus to cause thrombosis in arteria coronaria, complete infusion with the fastest speed.
In four kinds of methods, intracoronary injection is the most common, is secondly injection in Epicardium.These two kinds of methods have a common feature, have both required once to complete transplanting in a short period of time, continue medication or the probability of transplanting exists hardly.With under physiological condition, stem cell is by inflammatory mediator induction, chemotactic, progressively compare to the process of damaged myocardium migration along blood vessel, at present conventional implantation method and physiological process have huge difference, thus may be stem-cell therapy effect also one of factors reaching expection far away.Disposable infusion cytokine is because of the continuous erosion effect of blood flow, and after intracoronary injection, in cardiac muscle, concentration is lower, reduces the direct effect to heart, and simultaneously a large amount of cytokine enters body circulation with blood flow and absorbed by other non-target tissues, may there is potential hazard.In cardiac muscle, direct injection avoids the side effect such as the first pass effect of intravascular injection and hypotension, there is the advantages such as local drug concentration is high, targeting is good, but hold time of short duration in local after intramyocardial injection needs opening operation breast, cytokine injections, and skewness, hemangioma are formed and the shortcoming such as inflammatory reaction.
Summary of the invention
In view of this, the invention provides a kind of double mode heart in-situ perfusion system, the long-time infusion of cytokine/stem cell can be realized by pressure signal gate and electrocardiosignal gate two kinds of patterns, have safety, easy to operate concurrently, the feature that targeting is high, improves the therapeutic effect of Ischemic heart failure.
A kind of double mode heart in-situ perfusion system, comprises perfusion cannula, infusion connecting tube, pressure transducer, hydraulic pump, physiograph and signal screening device;
Wherein, pipe in described perfusion cannula comprise external coating and external coating inside two, the outer surface of described two interior pipes is completely coated by external coating, its monnolithic case is made up of straight part and hook portion, described hook portion is made up of segmental arc and straightway, and segmental arc connects with straight part; Two interior pipes one of described straightway corresponding position are endcapped and side opening, and another is distal opening, and its opening of interior pipe of side opening runs through external coating, and the end of two interior pipes that described straight part is corresponding is open architecture;
Described pressure transducer energy sensed pressure signal by pressure signal transmission to signal screening device;
It is also exported to signal screening device by the mode of the signal of telecommunication by the electrocardiosignal of described physiograph monitoring human;
Described discriminator can judge diastole time-histories according to the human ecg signal received or pressure signal, the control signal sending out hydraulic pump and close, the administration of hydraulic control pump property performance period;
Its integrated connection closes: the end of described perfusion cannula straight part two interior pipes is by infusion connecting tube connecting fluid press pump and pressure transducer respectively, endcapped and the interior pipe of side opening communicate with the pump discharge of hydraulic pump, open-ended interior pipe communicates with pressure transducer, described pressure transducer and signal screening device are electrically connected, and pressure transducer can send the pressure signal recorded during work to signal screening device; Described physiograph collects the electrocardiosignal of human body by the cardiac diagnosis lead being wrapped in human body wrist and ankle place, and physiograph and signal screening device are electrically connected, and physiograph sends the human ecg signal of collection to signal screening device; Described hydraulic pump and signal screening device are electrically connected, and signal screening device processes backward hydraulic pump to electrocardiosignal or pressure signal and sends and start or stop signal.
Further, under pressure signal gating patterns, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of the corresponding heart in this position, sends enabling signal to hydraulic pump; Wave trough position before the upstroke of next pressure wave unit, the systole of the corresponding heart in this position, sends stop signal to hydraulic pump.
Further, when described hydraulic pump receives termination signal, perform 10 milliseconds of pumpback actions.
Further, under electrocardiosignal gating patterns, when signal screening device detects the decent of T ripple in electrocardiogram, signal screening device sends enabling signal to hydraulic pump, and when the peak value of R ripple being detected, signal screening device sends stop signal to hydraulic pump;
Further, transfusion can be interrupted every one or several cardiac electrical cycle under electrocardiosignal gating patterns, the availability of medicinal liquid can be improved, reduce transfusion speed.
Further, described external coating is formed by polythene material and steel wire sulfuration, polythene material determines the hardness of perfusion cannula, shape and the frictional force with tunica intima, and steel wire forms the skeleton of perfusion cannula, makes that perfusion cannula chamber is unlikely to subside and have the anti-effect of fractureing.
Further, described perfusion cannula straight part be length 105-110cm, the external diameter of conduit is 5F-7F.
Further, the arc radius of the segmental arc of described perfusion cannula hook portion is 3-5mm, and the length of straightway is 8-12mm.
Further, the material that described interior pipe adopts is polyethylene or polrvinyl chloride.
Further, formation assembly integrated by described hydraulic pump, physiograph, pressure transducer and signal screening device, is convenient to medical personnel and carries out operation and maintenance.
Operation principle: during use, heart in-situ perfusion conduit of the present invention is placed into the corresponding site of heart through femoral artery, the corresponding arteria coronaria Dou Kou position of side opening on the straightway of hook portion, doctor is selection pressure signal gate and electrocardiosignal gating patterns according to circumstances.
Under pressure signal gating patterns, the arterial pressure of this position responded to by open-ended interior pipe by being communicated with pressure transducer, and to signal screening device sending pressure signal; Pressure signal obtains diastole time-histories after the process of signal screening device, and the rule that diastole time-histories pressed by signal screening device hydraulic control pump starts, by pipe in the opening of side to heart conveying liquid body.
Under electrocardiosignal gating patterns, electrocardiosignal obtains diastole time-histories after the process of signal screening device, and the rule that diastole time-histories pressed by signal screening device hydraulic control pump starts, by pipe in the opening of side to heart conveying liquid body.
Beneficial effect:
1, the present invention utilizes the blood flow of arteria coronaria Dou Kou to flow mostly to physiological characteristics coronarius at diastole, indwelling near the arteria coronaria Dou Kou through peripheral arterial delivery conduit being delivered to aortic root, conduit does not enter in coronary artery, at diastole by hydraulic pump through delivery conduit by stem cell, cytokine infusion, systole stops, and cell/liquid enters coronary artery with coronary blood flow.
2, hydraulic pump selectivity relaxing period start-up performance of the present invention is controlled by physiograph and discriminator block, can control perfusion opportunity accurately.Heart in-situ perfusion approach avoids the potential risk (cause that acute coronary is narrow or inaccessible, arteria coronaria is bored a hole by conduit, steel wire, sacculus coup injury lumen of vessels and cardiac tamponade, No-reflow phenoment etc. seriously jeopardize the coronary artery lesions complication of patient vitals) of open chest surgery and intracoronary catheter operation repeatedly, safety is higher, implement more easy, long-time perfusion can be realized.
3, the present invention possesses pressure signal gate and electrocardiosignal gate two kinds of patterns and carries out the selection controlled of infusing, and has enriched operational means, has been conducive to doctor and carries out operation technique selection according to the practical situation of patient.
4, the present invention is under pressure signal gating patterns, 10 milliseconds of pumpback actions are performed during each transfusion stop, avoiding in liquid-transport pipe-line liquid due to pressure inertia there is the phenomenon that the cytokine/stem cell of oozing out is sent out with artery blood flow whole body, reduce the side effect of drugs on patients, effectively can save treatment cost simultaneously.
Accompanying drawing explanation
Fig. 1 is system theory of constitution schematic diagram of the present invention.
Fig. 2 is the contour structures schematic diagram of the perfusion cannula of invention;
Fig. 3 is the structural representation of the perfusion cannula straight part of invention;
Fig. 4 is the position view of straightway at endocardial of perfusion cannula hook portion of the present invention;
Fig. 5 is electrocardiosignal gating patterns schematic diagram of the present invention;
Fig. 6 is electrocardiosignal gating patterns schematic diagram of the present invention (one, interval cardiac electrical cycle starts);
Fig. 7 is pressure signal gating patterns schematic diagram of the present invention.
Wherein, 1-external coating, pipe II, 6-straight part, 7-hook portion in pipe I, 4-side opening, 5-in 2-distal opening, 3-.
Detailed description of the invention
As shown in Figure 1, the invention provides a kind of double mode heart in-situ perfusion system, comprise perfusion cannula, infusion connecting tube, pressure transducer, hydraulic pump, physiograph and signal screening device;
Wherein, described perfusion cannula comprises interior pipe I 3 and the interior pipe II 5 of external coating 1 and external coating inside, the outer surface of described interior pipe I 3 and interior pipe II 5 is completely coated by external coating 1, as shown in Figure 2, its monnolithic case is made up of straight part 6 and hook portion 7, described hook portion 7 is made up of segmental arc and straightway, and segmental arc connects with straight part 6; As shown in Figure 3, the endcapped of the interior pipe I 3 of described straightway corresponding position and there is side opening 4, the distal opening of interior pipe II 5, the side opening of interior pipe I 3 runs through external coating 1, and the end of the interior pipe I 3 that described straight part is corresponding and interior pipe II 5 is open architecture; The length of described perfusion cannula straight part is 110cm, and the external diameter of conduit is 6F, and the arc radius of the segmental arc of perfusion cannula hook portion is 4mm, and the length of straightway is 10mm; Described external coating 1 is formed by polythene material and steel wire sulfuration, polythene material determines the hardness of perfusion cannula, shape and the frictional force with tunica intima, steel wire forms the skeleton of perfusion cannula, make that perfusion cannula chamber is unlikely to subside and have the anti-effect of fractureing, the material of interior pipe is politef.
In described perfusion cannula straight part, the end of pipe I 3 and interior pipe II 5 is by infusion connecting tube connecting fluid press pump and pressure transducer respectively, interior pipe I 3 communicates with the pump discharge of infusion pump, interior pipe II 5 communicates with pressure transducer, described pressure transducer and signal screening device are electrically connected, and pressure transducer can send the pressure signal recorded during work to signal screening device; Described physiograph by the cardiac diagnosis lead of the wrist and ankle place that are connected to human body, the electrocardiosignal of record human body, physiograph and signal screening device are electrically connected, and send the human ecg signal of collection to signal screening device; Described hydraulic pump and signal screening device are electrically connected, and send start or stop signal after signal screening device processes electrocardiosignal or pressure signal to hydraulic pump.
Operation principle: during use, heart in-situ perfusion conduit of the present invention is placed into the corresponding site of heart through femoral artery, as shown in Figure 4, the corresponding arteria coronaria Dou Kou position of the side opening on the straightway of hook portion, doctor is selection pressure signal gate and electrocardiosignal gating patterns according to circumstances.
As shown in Figure 5, under electrocardiosignal gating patterns, when signal screening device detects the decent of T ripple in electrocardiogram, signal screening device sends enabling signal to hydraulic pump, and when the peak value of R ripple being detected, signal screening device sends stop signal to hydraulic pump; Pressure signal obtains diastole time-histories after the process of signal screening device, and the rule that diastole time-histories pressed by signal screening device hydraulic control pump starts, by the side opening of interior pipe I 3 to heart conveying liquid body.
As shown in Figure 6, transfusion can be interrupted every one or several cardiac electrical cycle under electrocardiosignal gating patterns, the availability of medicinal liquid can be improved, reduce transfusion speed.
As shown in Figure 7, under pressure signal gating patterns, the pressure of this position responded to by open-ended interior pipe by being communicated with pressure transducer, and to signal screening device sending pressure signal; When described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of the corresponding heart in this position, sends enabling signal to hydraulic pump; Wave trough position before the upstroke of next pressure wave unit, the systole of the corresponding heart in this position, sends stop signal to hydraulic pump.Pressure signal obtains diastole time-histories after the process of signal screening device, and the rule that diastole time-histories pressed by signal screening device hydraulic control pump starts, by the side opening of interior pipe I 3 to heart conveying liquid body.
In sum, these are only preferred embodiment of the present invention, be not intended to limit protection scope of the present invention.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. a double mode heart in-situ perfusion system, is characterized in that, comprises perfusion cannula, infusion connecting tube, pressure transducer, hydraulic pump, physiograph and signal screening device;
Wherein, pipe in described perfusion cannula comprise external coating and external coating inside two, the outer surface of described two interior pipes is completely coated by external coating, its monnolithic case is made up of straight part and hook portion, described hook portion is made up of segmental arc and straightway, and segmental arc connects with straight part; Two interior pipes one of described straightway corresponding position are endcapped and side opening, and another is distal opening, and its opening of interior pipe of side opening runs through external coating, and the end of two interior pipes that described straight part is corresponding is open architecture;
Described pressure transducer energy sensed pressure signal by pressure signal transmission to signal screening device;
It is also exported to signal screening device by the mode of the signal of telecommunication by the electrocardiosignal of described physiograph monitoring human;
Described discriminator can judge diastole time-histories according to the human ecg signal received or pressure signal, the control signal sending out hydraulic pump and close, the administration of hydraulic control pump property performance period;
Its integrated connection closes: the end of described perfusion cannula straight part two interior pipes is by infusion connecting tube connecting fluid press pump and pressure transducer respectively, endcapped and the interior pipe of side opening communicate with the pump discharge of hydraulic pump, open-ended interior pipe communicates with pressure transducer, described pressure transducer and signal screening device are electrically connected, and pressure transducer can send the pressure signal recorded during work to signal screening device; Described physiograph is also by being wrapped in the cardiac diagnosis lead at human body wrist and ankle place, and collect the electrocardiosignal of human body, physiograph and signal screening device are electrically connected, and physiograph sends the human ecg signal of collection to signal screening device; Described hydraulic pump and signal screening device are electrically connected, and signal screening device processes backward hydraulic pump to electrocardiosignal or pressure signal and sends and start or stop signal.
2. double mode heart in-situ perfusion system as claimed in claim 1, it is characterized in that, under pressure signal gating patterns, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of the corresponding heart in this position, sends enabling signal to hydraulic pump; Wave trough position before the upstroke of next pressure wave unit, the systole of the corresponding heart in this position, sends stop signal to hydraulic pump.
3. double mode heart in-situ perfusion system as claimed in claim 2, is characterized in that, when described hydraulic pump receives termination signal, performs 10 milliseconds of pumpback actions.
4. double mode heart in-situ perfusion system as claimed in claim 1, it is characterized in that, under electrocardiosignal gating patterns, when signal screening device detects the decent of T ripple in electrocardiogram, signal screening device sends enabling signal to hydraulic pump, when the peak value of R ripple being detected, signal screening device sends stop signal to hydraulic pump.
5. double mode heart in-situ perfusion system as claimed in claim 4, is characterized in that, under electrocardiosignal gating patterns, one, interval or several cardiac electrical cycle are interrupted transfusion.
6. the double mode heart in-situ perfusion system as described in claim 1,2,3,4 or 5, it is characterized in that, described external coating is formed by polythene material and steel wire sulfuration.
7. the double mode heart in-situ perfusion system as described in claim 1,2,3,4 or 5, is characterized in that, described perfusion cannula straight part be length 105-110cm, the external diameter of conduit is 5F-7F.
8. the double mode heart in-situ perfusion system as described in claim 1,2,3,4 or 5, it is characterized in that, the arc radius of the segmental arc of described perfusion cannula hook portion is 3-5mm, the length of straightway is 8-12mm.
9. the double mode heart in-situ perfusion system as described in claim 1,2,3,4 or 5, is characterized in that, formation assembly integrated by described hydraulic pump, physiograph, pressure transducer and signal screening device.
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| CN201510363454.XA CN105126237B (en) | 2015-06-26 | 2015-06-26 | A kind of double mode heart situ perfusion system |
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| CN105126237B CN105126237B (en) | 2018-04-24 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108359604A (en) * | 2018-01-25 | 2018-08-03 | 山东百多安医疗器械有限公司 | A kind of conveying of stem cell seed and microenvironment regulating system |
| WO2021243885A1 (en) * | 2020-06-04 | 2021-12-09 | 苏州润迈德医疗科技有限公司 | Gate-control radiography injection device and injection method |
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| WO2021243885A1 (en) * | 2020-06-04 | 2021-12-09 | 苏州润迈德医疗科技有限公司 | Gate-control radiography injection device and injection method |
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