CN104906655A - Establishment method of transfusion liquid drainage conditions of non-leaking transfusion soft bottles - Google Patents

Establishment method of transfusion liquid drainage conditions of non-leaking transfusion soft bottles Download PDF

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Publication number
CN104906655A
CN104906655A CN201510402222.0A CN201510402222A CN104906655A CN 104906655 A CN104906655 A CN 104906655A CN 201510402222 A CN201510402222 A CN 201510402222A CN 104906655 A CN104906655 A CN 104906655A
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China
Prior art keywords
transfusion
soft
transfusion bottle
bottle
condition
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CN201510402222.0A
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Chinese (zh)
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CN104906655B (en
Inventor
王幼民
徐彬雪
唐铃凤
马飞红
帅进文
李凯
单学军
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Anhui Polytechnic University
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Anhui Polytechnic University
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features

Abstract

The invention provides an establishment method of transfusion liquid drainage conditions of non-leaking transfusion soft bottles. The establishment method of the transfusion liquid drainage conditions of the non-leaking transfusion soft bottles includes following steps: step 1, using a theoretical calculation formula to confirm experimental factors of the transfusion liquid drainage conditions of the non-leaking transfusion soft bottles; step 2, performing a drainage condition experiment on various specifications of the transfusion soft bottles with different types of syringe needles according to the confirmed experimental factors of the transfusion liquid drainage conditions of the non-leaking transfusion soft bottles; step 3, performing data fitting according to experimental data measured in the drainage condition experiment so as to obtain a fitting curve between the specifications of the transfusion soft bottles and minimal pressure values of the transfusion soft bottles when transfusion liquid in the transfusion soft bottles is drained. The establishment method of the transfusion liquid drainage conditions of the non-leaking transfusion soft bottles explains drainage performance of the non-leaking transfusion soft bottles from a theory level, provides a theoretical basis to development and study of new transfusion soft bottles, performs an analytical test on experimental models of the various specifications of the transfusion soft bottles, and obtains a relationship between the specifications of all the transfusion soft bottles and the minimal drainage pressure values.

Description

A kind of No leakage soft transfusion bottle transfusion drains the method for building up of condition
Technical field
The present invention relates to soft transfusion bottle infusion method field, relate to the method for building up that the transfusion of a kind of No leakage soft transfusion bottle drains condition specifically.
Background technology
The domestic research in this field is at present only limitted to qualitative interpretation or description of test, lacks theoretical foundation and quantitative analysis.Through theory analysis, experimental verification, the several link of software simulation, substantially determine existing several soft transfusion bottle to flow automatically the condition drained, namely under certain suspension height, the condition that drains of existing soft transfusion bottle is relevant with the gas liquid ratio of original state, mechanical property with soft transfusion bottle material is relevant with soft transfusion bottle external pressure instability modes, relevant with infusion needle diameter, the viscosity of temperature and medicinal liquid also has a certain impact in addition.Research finds, the mechanical property of soft transfusion bottle material, initial gas liquor ratio, and the size of suspension height, syringe needle internal diameter affects soft transfusion bottle to meet most important four factors drained under certain fast condition.Performance is drained for what can explain soft transfusion bottle from principal level, theoretical foundation is provided to the R and D of new soft transfusion bottle, the flow condition of medicinal liquid in infusion process in this No leakage soft transfusion bottle must be known, experiment adopts flow analysis software for this reason, numerical analysis is carried out to infusion process, thus obtains certain drip (minimum speed is 40/min) in fast situation and reaching condition from draining meeting.
Summary of the invention
For above-mentioned the deficiencies in the prior art, the invention provides the method for building up that the transfusion of a kind of No leakage soft transfusion bottle drains condition, overcome and be only limitted to qualitative interpretation or description of test in this field, lack a difficult problem for theoretical foundation and quantitative analysis, provide theoretical foundation can to the R and D of new soft transfusion bottle simultaneously.
To achieve these goals, the invention provides the method for building up that the transfusion of a kind of No leakage soft transfusion bottle drains condition, comprise the steps:
Step one: utilize the transfusion of theoretical calculation formula determination soft transfusion bottle to drain the empirical factor of condition;
Step 2: the empirical factor draining condition according to the soft transfusion bottle transfusion determined, drains condition experiment to there being each specification soft transfusion bottle of different model syringe needle;
Step 3: carry out data fitting according to draining the experimental data that condition experiment records, the matched curve of minimal pressure force value when obtaining soft transfusion bottle specification and drain.
Be the force value of 40/min by minimum speed in pressure test device test all size soft transfusion bottle transfusion experiment in described step 2.
Described step one theoretical calculation formula is
ΔE 2 = V 2 2 2 g + Z 2 + P 2 ρ g - ( V 1 2 2 g + Z 1 + P 1 ρ g ) , Wherein V 1for the flow velocity of intravenous injection small pinhead during original state, P 1for the pressure of vein blood vessel simulator, △ E 2for the loss of soft transfusion bottle infusion process main pipe rail, V 2for the flow velocity of liquid in bottle during final states, Z 2for liquid height in bottle during final states is to the height of vein blood vessel simulator, Z 1for the height of vein simulator, P 2for final states pressure.
Described step 3 infuses experimental model at least to get n to all size soft transfusion bottle 1group (v, p j) experimental data, to n 1group experimental data value is averaged, and chooses the pressure value in soft transfusion bottle when a speed is 40/min, is averaged, obtains soft transfusion bottle and drain pressure under all size, wherein j=1 ~ n obtained data 1, 4<n 1<10; p jfor the pressure in the soft transfusion bottle that a jth soft transfusion bottle drips when speed is 40/min; Drip fast v=40 and drip/min.
Described all size soft transfusion bottle comprises 100ml, 250ml, 500ml specification soft transfusion bottle.Described 100ml, 250ml specification soft transfusion bottle adopts E type syringe needle, and described 500ml specification soft transfusion bottle adopts F type syringe needle.
Described matched curve carries out matching by MATLAB software to the pressure value under the condition that drains of experiment gained to obtain.
Described soft transfusion bottle comprises soft bottle body, tube for transfusion and the pressure test device for measuring soft transfusion bottle pressure of the inside of a bottle, and tube for transfusion is provided with Murphy type tube.
The U-tube that described pressure test device comprises needle tubing, is connected with needle tubing, pressure test device is inserted into soft bottle body by needle tubing, U-shaped pipe one end is communicated with air, pure water is filled with in U-tube, soft bottle body inner liquid medicine enters U-tube by needle tubing, be provided with air barrier between U-tube inner liquid medicine and water, described U-tube is provided with rule, can read scale accurately.Described rule is provided with two 0 graduation marks, can be set to negative value below zero graduation, top be on the occasion of, described two 0 graduation marks lay respectively in U-tube two VERTICAL TUBE, U-tube dress water time horizontal plane overlap with 0 graduation mark of U-tube both sides rule.After in soft transfusion bottle, liquid constantly declines, U-shaped pipe connects open to atmosphere one end because atmospheric effect is by the direction of the pure water pressure in U-tube to soft transfusion bottle, U-shaped pipe connect open to atmosphere one end pure water downwards decline scale be-h, the corresponding U-tube other end pure water be connected with needle tubing also rises h, and the pressure in soft transfusion bottle can be calculated by 2 times of the poor h of liquid level.Be provided with air barrier herein between U-tube inner liquid medicine and water and can make medicinal liquid and water segregation, when forming liquid level difference, pure water avoids pure water to enter soft transfusion bottle after soft transfusion bottle moves, what certainly sealing coat here will be arranged is reasonable, can not be pressed in the middle of soft transfusion bottle reaching pure water when soft transfusion bottle drains the pressure of condition.
Beneficial effect: the present invention drains performance from principal level explanation soft transfusion bottle, theoretical foundation is provided to the R and D of new soft transfusion bottle, and analytical test is carried out to the experimental model that the soft transfusion bottle of specification not of the same race is infused, obtains each soft transfusion bottle specification and the relation draining minimum pressure.
Accompanying drawing explanation
Fig. 1 is specific embodiment of the invention pressure test device structural representation;
Wherein 1-soft transfusion bottle, 2-tube for transfusion, 3-Murphy type tube, 4-U type pipe;
Fig. 2 is the a-quadrant rule partial enlarged drawing in Fig. 1 in U-tube;
Fig. 3 is each soft transfusion bottle specification of the specific embodiment of the invention and the graph of relation draining condition pressure.
Detailed description of the invention
Contrast accompanying drawing below, by the description to embodiment, the specific embodiment of the present invention is as the effect of the mutual alignment between the shape of involved each component, structure, each several part and annexation, each several part and operation principle, manufacturing process and operation using method etc., be described in further detail, have more complete, accurate and deep understanding to help those skilled in the art to inventive concept of the present invention, technical scheme.
The present invention, by analyzing theoretical formula method, can draw the mobility status of soft transfusion bottle in infusion process and the pressure loss situation in flow process thereof, thus soft transfusion bottle of retrodicting drain condition, determine that soft transfusion bottle drains the empirical factor of condition.And then carry out the foundation that soft transfusion bottle drains condition experiment, changed by the pressure using the pressure test device in soft transfusion bottle infusion process to measure in bottle.In infusion process, along with the carrying out of transfusion, liquid level declines gradually, pressure of the inside of a bottle also gradually changes, before emptying, for ensureing 40/min lowest speed (from Murphy type tube observation), soft transfusion bottle must possess certain pressure, this pressure is emptying minimum pressure, be to seek drain condition; MATLAB software is used to carry out to the pressure value under the condition that drains of experiment gained the graph of relation that matching obtains each specification soft transfusion bottle and emptying condition (i.e. minimum pressure during emptying) time again.Concrete steps are as follows:
Steps A: theoretical formula method
During final states, to the greatest extent, the energy of final states should overcome the loss of pipe resistance to make fluid drips in infusion bottle.
&Delta;E 2 = V 2 2 2 g + Z 2 + P 2 &rho; g - ( V 1 2 2 g + Z 1 + P 1 &rho; g )
h 1 = &gamma; 1 d v 2 2 g
h 2 = &Sigma;&zeta; v 2 2 g
Wherein:
V 1the flow velocity (m/min) of intravenous injection small pinhead during-original state
P 1the pressure (pa) of-vein blood vessel simulator
△ E 2-soft transfusion bottle infusion process main pipe rail loss (m)
V 2the flow velocity (m/min) of liquid in bottle during-final states
Z 2: during final states in bottle liquid height to the height (m) of vein blood vessel simulator
Z 1the height (m) of-vein simulator
P 2-final states pressure (pa)
H 1-tube for transfusion linear loss (m)
H 2-tube for transfusion local losses (m)
L-tube for transfusion length (m)
D-tube for transfusion caliber (m)
γ-loss factor
ζ-local loss coefficient
V-tube for transfusion drips speed (m/min)
△ E 2relevant with linear loss and local loss coefficient, look into phase---infusion pipeline linear loss and local loss coefficient can be obtained, by Z 1, Z 2, V 1, V 2, γ, ζ, V substitute into above formula must there emerged a specification soft transfusion bottle meet drip to the greatest extent under 40 conditions required per minute time P 2minima be respectively A, B and C.
Conclusion: through Theoretical Calculation, each soft transfusion bottle sees the following form from draining condition
Step B: drain condition experiment
Can record in the force value meeting (minimum speed is 40/min) in certain fast situation by using pressure test device in soft transfusion bottle infusion process; Carry out the experiment of n group, remove the numerical value that interference factor impact is larger, to remaining n 1group empirical value be averaged can obtain all size soft transfusion bottle drain condition.
The soft transfusion bottle experimental model of 100ml specification: at least get n 1group (v, p j) experimental data, to this n 1group empirical value is averaged, and chooses the pressure value in soft transfusion bottle when to drip speed be 40/min, is averaged can obtains soft transfusion bottle drain pressure under 100ml specification obtained data.
Wherein:
J＝1～n 1，4<n 1<10；
P is the pressure in a jth soft transfusion bottle drips when speed is 40/min soft transfusion bottle;
Drip fast V=40 and drip/min;
Pressure P=[p 1, p 2, p 3, p 4, p 5, p 6];
The soft transfusion bottle experimental model of 250ml specification: at least get n 1group (v, p j) experimental data, to this n 1group empirical value is averaged, and chooses the pressure value in soft transfusion bottle when to drip speed be 40/min, is averaged can obtains soft transfusion bottle drain pressure under 250ml specification obtained data.
Wherein:
J＝1～n 1，4<n 1<10；
P is the pressure in a jth soft transfusion bottle drips when speed is 40/min soft transfusion bottle;
Drip fast V=40 and drip/min;
Pressure P=[p 1, p 2, p 3, p 4];
The soft transfusion bottle experimental model of 500ml specification: at least get n 1group (v, p j) experimental data, to this n 1group empirical value is averaged, and chooses the pressure value in soft transfusion bottle when to drip speed be 40/min, is averaged can obtains soft transfusion bottle drain pressure under 500ml specification obtained data.
Wherein:
J＝1～n 1，4<n 1<10；
P is the pressure in a jth soft transfusion bottle drips when speed is 40/min soft transfusion bottle;
Drip fast V=40 and drip/min;
Pressure P=[p 1, p 2, p 3, p 4,p 5];
The condition that drains of 100ml, 250ml, 500ml specification soft transfusion bottle sees the following form:
All kinds of soft transfusion bottle drain condition
100ml soft transfusion bottle E syringe needle P≥A 1(pa)
250ml soft transfusion bottle E syringe needle P≥-B 1(pa)
500ml soft transfusion bottle F syringe needle P≥-C 1(pa)
Step C:
By MATLAB software, matching is carried out to acquisition data and obtains each specification soft transfusion bottle and the relation curve draining condition pressure (when namely draining minimum pressure), as shown in Figure 3.
Above by reference to the accompanying drawings to invention has been exemplary description; obvious specific implementation of the present invention is not subject to the restrictions described above; as long as have employed the improvement of the various unsubstantialities that method of the present invention is conceived and technical scheme is carried out; or design of the present invention and technical scheme directly applied to other occasion, all within protection scope of the present invention without to improve.

Claims (9)

1. the transfusion of No leakage soft transfusion bottle drains a method for building up for condition, comprises the steps:
Step one: utilize the transfusion of theoretical calculation formula determination soft transfusion bottle to drain the empirical factor of condition;
Step 2: the empirical factor draining condition according to the soft transfusion bottle transfusion determined, drains condition experiment to there being each specification soft transfusion bottle of different model syringe needle;
Step 3: carry out data fitting according to draining the experimental data that condition experiment records, the matched curve of minimal pressure force value when obtaining soft transfusion bottle specification and drain.
2. No leakage soft transfusion bottle transfusion according to claim 1 drains the method for building up of condition, it is characterized in that: described step one theoretical calculation formula is &Delta;E 2 = V 2 2 2 g + Z 2 + P 2 &rho; g - ( V 1 2 2 g + Z 1 + P 1 &rho; g ) , Wherein V 1for the flow velocity of intravenous injection small pinhead during original state, P 1for the pressure of vein blood vessel simulator, Δ E 2for the loss of soft transfusion bottle infusion process main pipe rail, V 2for the flow velocity of liquid in bottle during final states, Z 2for liquid height in bottle during final states is to the height of vein blood vessel simulator, Z 1for the height of vein simulator, P 2for final states pressure.
3. No leakage soft transfusion bottle according to claim 1 transfusion drains the method for building up of condition, it is characterized in that: described step 3 tests the experimental data that records at least to get n 1group (v, p j) experimental data, to n 1group experimental data value is averaged, and chooses the pressure value in soft transfusion bottle when a speed is 40/min, is averaged, obtains soft transfusion bottle and drain pressure under all size, wherein j=1 ~ n obtained data 1, 4<n 1<10; p jfor the pressure in the soft transfusion bottle that a jth soft transfusion bottle drips when speed is 40/min; Drip fast v=40 and drip/min.
4. No leakage soft transfusion bottle transfusion according to claim 1 drains the method for building up of condition, it is characterized in that: described all size soft transfusion bottle comprises 100ml, 250ml, 500ml specification soft transfusion bottle.
5. No leakage soft transfusion bottle transfusion according to claim 4 drains the method for building up of condition, and it is characterized in that: described 100ml, 250ml specification soft transfusion bottle adopts E type syringe needle, described 500ml specification soft transfusion bottle adopts F type syringe needle.
6. No leakage soft transfusion bottle transfusion according to claim 1 drains the method for building up of condition, it is characterized in that: described matched curve carries out matching by MATLAB software to the pressure value under the condition that drains of experiment gained to obtain.
7. No leakage soft transfusion bottle transfusion according to claim 1 drains the method for building up of condition, it is characterized in that: described soft transfusion bottle comprises soft bottle body, tube for transfusion and the pressure test device for measuring soft transfusion bottle pressure of the inside of a bottle, and tube for transfusion is provided with Murphy type tube.
8. No leakage soft transfusion bottle transfusion according to claim 7 drains the method for building up of condition, it is characterized in that: the U-tube that described pressure test device comprises needle tubing, is connected with needle tubing, pressure test device is inserted into soft bottle body by needle tubing, U-shaped pipe one end is communicated with air, pure water is filled with in U-tube, soft bottle body inner liquid medicine enters U-tube by needle tubing, is provided with air barrier between U-tube inner liquid medicine and water, and described U-tube is provided with rule.
9. No leakage soft transfusion bottle transfusion according to claim 8 drains the method for building up of condition, it is characterized in that: described rule is provided with two 0 graduation marks, described two 0 graduation marks lay respectively in U-tube two VERTICAL TUBE, and during U-tube dress water, horizontal plane overlaps with 0 graduation mark of U-tube both sides rule.
CN201510402222.0A 2015-07-08 2015-07-08 A kind of No leakage soft transfusion bottle transfusion drains the method for building up of condition Expired - Fee Related CN104906655B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5507737A (en) * 1993-04-22 1996-04-16 Siemens Elema Ab Apparatus for determining the volume of a bellows reservoir for medication in an implantable infusion system
US20070228071A1 (en) * 2006-02-09 2007-10-04 Dean Kamen Fluid delivery systems and methods
WO2010059588A1 (en) * 2008-11-20 2010-05-27 Medtronic, Inc. Pressure based refill status monitor for implantable pumps
US20120265141A1 (en) * 2011-04-18 2012-10-18 Medtronic, Inc. Detecting a full reservoir of an implantable infusion device
CN104302350A (en) * 2012-03-07 2015-01-21 德卡产品有限公司 Infusion pump assembly

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5507737A (en) * 1993-04-22 1996-04-16 Siemens Elema Ab Apparatus for determining the volume of a bellows reservoir for medication in an implantable infusion system
US20070228071A1 (en) * 2006-02-09 2007-10-04 Dean Kamen Fluid delivery systems and methods
WO2010059588A1 (en) * 2008-11-20 2010-05-27 Medtronic, Inc. Pressure based refill status monitor for implantable pumps
US20120265141A1 (en) * 2011-04-18 2012-10-18 Medtronic, Inc. Detecting a full reservoir of an implantable infusion device
CN104302350A (en) * 2012-03-07 2015-01-21 德卡产品有限公司 Infusion pump assembly

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