CN104873312A - Magnesium alloy cardiovascular stent and manufacturing method thereof - Google Patents
Magnesium alloy cardiovascular stent and manufacturing method thereof Download PDFInfo
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- CN104873312A CN104873312A CN201510278853.6A CN201510278853A CN104873312A CN 104873312 A CN104873312 A CN 104873312A CN 201510278853 A CN201510278853 A CN 201510278853A CN 104873312 A CN104873312 A CN 104873312A
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- magnesium alloy
- polylactic acid
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- protective layer
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Abstract
A magnesium alloy cardiovascular stent comprises a polylactic acid protection layer and a magnesium alloy stent body, and is characterized in that the magnesium alloy stent body is wrapped with the polylactic acid protection layer; the polylactic acid protection layer is used for protecting the magnesium alloy stent body from rapidly decomposing in the vascular remodeling process, and gaps are distributed in the polylactic acid protection layer at random, are used for controlling the decomposition speed of the magnesium alloy stent body in a blood vessel and will not jam the blood vessel again. The polylactic acid protection layer and the unique small gap structure can effectively protect the magnesium alloy stent body from rapidly decomposing. Meanwhile, due to the small gap structure, the magnesium alloy stent body is decomposed just after vascular remodeling and will not accumulate in the blood vessel. As the magnesium alloy and the polyactic acid are the basic materials, the magnesium alloy cardiovascular stent will not affect human health.
Description
Technical field
The present invention relates to a kind of angiocarpy bracket, especially a kind of magnesium alloy angiocarpy bracket and manufacture method.
Background technology
Traditional intravascular stent refers on the basis that is shaped at tube chamber balloon expandable, inserts inner support support stenosis occlusion section blood vessel to reach in pathological changes section, reduces blood vessel elasticity retraction and moulding again, keeps the object that tube chamber blood flow is unobstructed.Through the research of countless experts and scholars, but existing angiocarpy bracket has developed into support oneself expansion, and surface has the degradable alloy bracket of film layer or coating layer.
Such as Chinese patent discloses a kind of angiocarpy bracket, application number: 201110179339.9, the applying date: 2011-06-29, the invention discloses a kind of angiocarpy bracket, comprise magnesium alloy bracket body, the protective layer that thickness is 2-4 μm is attached with in described magnesium alloy bracket surface, protective layer adheres to 10-15 μm of medicine layer outward, described protective layer immerses in following conversional solution by magnesium alloy bracket body, at 90 DEG C of temperature, to soak and obtain for 10 hours, the composition of described conversional solution and volume ratio are: the sodium hydrogen phosphate=1:2-5 of the phosphoric acid of 0.5-1%: 0.5-1%, described medicine layer is made up of medicine and high molecular polymer, the content of described medicine layer Chinese medicine, 20-40% is counted with mass fraction.The invention has the beneficial effects as follows: magnesium alloy medicine releasing bracket that can be degradable, not only there is the feature that metal rack intensity is high, but also can degrade gradually, then absorbed by organism, in addition, this support has good biocompatibility and anti-hamartoplasia performance.
The weak point of this technical scheme is to be provided with protective layer and medicine layer outside described magnesium alloy, and protective layer and medicine layer all have complicated component and the loaded down with trivial details feature of processing technology.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of easy to make and angiocarpy bracket that can be degraded by human body completely with and preparation method thereof.
Technical scheme of the present invention is:
A kind of magnesium alloy angiocarpy bracket; comprise polylactic acid protective layer and magnesium alloy bracket; it is characterized in that; described magnesium alloy bracket Surface coating one deck polylactic acid protective layer; its effect is that protection magnesium alloy bracket can not fast decoupled in vascular remodeling process; random distribution space on described polylactic acid protective layer, its effect controls magnesium alloy bracket decomposition rate in the blood vessel, can not again result in blockage in the blood vessel.
Particularly, described magnesium alloy bracket is self-expanding stent, and its effect reduces operation easier.
Particularly, described polylactic acid protective layer adopts polylactic acid and collagen protein to make.
Further, described its thickness of polylactic acid protective layer is 4 μm-14 μm and the thickness difference of its magnesium alloy bracket various piece is less than 6 μm.
A manufacture method for magnesium alloy angiocarpy bracket, is characterized in that, its step comprises:
1) PLA solution is prepared;
2) by step 1) solution prepared is sprayed on aluminium alloy post surface by film applicator;
3) lyophilization.
Particularly, described step 1) to prepare PLA solution and be: collagen protein being dissolved in concentration is make collagen solution in the acetone soln of 0.05mol/L; Polylactic acid being dissolved in concentration is make PLA solution in the acetone soln of 0.05mol/L; Collagen solution and PLA solution are mixed according to the ratio of weight ratio 6:4.
Particularly, described step 3) lyophilization is: the magnesium alloy bracket coating polylactic acid is placed in-80 DEG C of environment freezing and carry out drying at least 15 hours and rate of temperature fall is at least 8 DEG C/min.
Beneficial effect of the present invention is: structure of the present invention is simple; by the fine pore structure of polylactic acid protective layer and its uniqueness; can available protecting magnesium alloy bracket body can not too fast disintegrate, can't be formed at Ink vessel transfusing pile up because little gap structure makes magnesium alloy bracket after vascular remodeling also just complete disintegrate simultaneously.Owing to adopting magnesium alloy and polylactic acid to be stock, this product can't damage human body health.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described further:
Embodiment 1
A kind of magnesium alloy angiocarpy bracket; comprise polylactic acid protective layer and magnesium alloy bracket; it is characterized in that; described magnesium alloy bracket Surface coating one deck polylactic acid protective layer; its effect is that protection magnesium alloy bracket can not fast decoupled in vascular remodeling process; random distribution space on described polylactic acid protective layer, its effect controls magnesium alloy bracket decomposition rate in the blood vessel, can not again result in blockage in the blood vessel.
Particularly, described magnesium alloy bracket is self-expanding stent, and its effect reduces operation easier.
Particularly, described polylactic acid protective layer adopts polylactic acid and collagen protein to make.
Described its thickness of polylactic acid protective layer is 10 μm.
A manufacture method for magnesium alloy angiocarpy bracket, is characterized in that, its step comprises:
4) PLA solution is prepared;
5) by step 1) solution prepared is sprayed on aluminium alloy post surface by film applicator;
6) lyophilization.
Particularly, described step 1) to prepare PLA solution and be: collagen protein being dissolved in concentration is make collagen solution in the acetone soln of 0.05mol/L; Polylactic acid being dissolved in concentration is make PLA solution in the acetone soln of 0.05mol/L; Collagen solution and PLA solution are mixed according to the ratio of weight ratio 6:4.
Particularly, described step 3) lyophilization is: the magnesium alloy bracket coating polylactic acid is placed in-80 DEG C of environment freezing and carry out drying 15 hours and rate of temperature fall 9 DEG C/min.
Embodiment 2
A kind of magnesium alloy angiocarpy bracket; comprise polylactic acid protective layer and magnesium alloy bracket; it is characterized in that; described magnesium alloy bracket Surface coating one deck polylactic acid protective layer; its effect is that protection magnesium alloy bracket can not fast decoupled in vascular remodeling process; random distribution space on described polylactic acid protective layer, its effect controls magnesium alloy bracket decomposition rate in the blood vessel, can not again result in blockage in the blood vessel.
Particularly, described magnesium alloy bracket is self-expanding stent, and its effect reduces operation easier.
Particularly, described polylactic acid protective layer adopts polylactic acid and collagen protein to make.
Described its thickness of polylactic acid protective layer is 10 μm.
A manufacture method for magnesium alloy angiocarpy bracket, is characterized in that, its step comprises:
7) PLA solution is prepared;
8) by step 1) solution prepared is sprayed on aluminium alloy post surface by film applicator;
9) lyophilization.
Particularly, described step 1) to prepare PLA solution and be: collagen protein being dissolved in concentration is make collagen solution in the acetone soln of 0.05mol/L; Polylactic acid being dissolved in concentration is make PLA solution in the acetone soln of 0.05mol/L; Collagen solution and PLA solution are mixed according to the ratio of weight ratio 6:4.
Particularly, described step 3) lyophilization is: the magnesium alloy bracket coating polylactic acid is placed in-80 DEG C of environment freezing and carry out drying 20 hours and rate of temperature fall 7 DEG C/min.
Embodiment 1 is only cryodesiccated time and rate of temperature fall with the difference of embodiment 2.The former adopts quick freezing dry, and its effect produces more abundant micro-pore, and this method is applicable to making the product of expecting that the vascular remodeling time is shorter; The latter adopts gentle lyophilization, and its effect makes film forming smooth, is suitable for making the product of expecting that the vascular remodeling time is longer.
What describe in above-described embodiment and description just illustrates principle of the present invention and most preferred embodiment; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.
Claims (7)
1. a magnesium alloy angiocarpy bracket, comprises polylactic acid protective layer and magnesium alloy bracket, it is characterized in that, described magnesium alloy bracket Surface coating one deck polylactic acid protective layer, random distribution space on described polylactic acid protective layer.
2. a kind of magnesium alloy angiocarpy bracket according to claim 1, is characterized in that: described magnesium alloy bracket is self-expanding stent.
3. a kind of magnesium alloy angiocarpy bracket according to claim 1, is characterized in that: described polylactic acid protective layer adopts polylactic acid and collagen protein to make.
4. a kind of magnesium alloy angiocarpy bracket according to claim 1, is characterized in that: described its thickness of polylactic acid protective layer is 4 μm-14 μm and the thickness difference of its magnesium alloy bracket various piece is less than 6 μm.
5. a manufacture method for magnesium alloy angiocarpy bracket, is characterized in that, its step comprises:
1) PLA solution is prepared;
2) by step 1) solution prepared is sprayed on aluminium alloy post surface by film applicator;
3) lyophilization.
6. the manufacture method of a kind of magnesium alloy angiocarpy bracket according to claim 5, is characterized in that: described step 1) to prepare PLA solution and be: collagen protein being dissolved in concentration is make collagen solution in the acetone soln of 0.05mol/L; Polylactic acid being dissolved in concentration is make PLA solution in the acetone soln of 0.05mol/L; Collagen solution and PLA solution are mixed according to the ratio of weight ratio 6:4.
7. the manufacture method of a kind of magnesium alloy angiocarpy bracket according to claim 5, is characterized in that: described step 3) lyophilization is: the magnesium alloy bracket coating polylactic acid is placed in-80 DEG C of environment freezing and carry out drying at least 15 hours and rate of temperature fall is at least 8 DEG C/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510278853.6A CN104873312B (en) | 2015-05-27 | 2015-05-27 | Magnesium alloy cardiovascular stent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510278853.6A CN104873312B (en) | 2015-05-27 | 2015-05-27 | Magnesium alloy cardiovascular stent |
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| CN104873312A true CN104873312A (en) | 2015-09-02 |
| CN104873312B CN104873312B (en) | 2017-02-22 |
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| CN201510278853.6A Expired - Fee Related CN104873312B (en) | 2015-05-27 | 2015-05-27 | Magnesium alloy cardiovascular stent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106178139A (en) * | 2016-07-05 | 2016-12-07 | 苏州脉悦医疗科技有限公司 | A kind of support and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060020331A1 (en) * | 2002-07-12 | 2006-01-26 | Cook Incorporated | Coated medical device |
| CN1857742A (en) * | 2005-04-30 | 2006-11-08 | 中国科学院金属研究所 | Biomedicine implant material with controllable degrading rate and its application |
| CN1919361A (en) * | 2005-08-26 | 2007-02-28 | 中国科学院金属研究所 | Biomedical degradation-absorption-controllable macromolecule metal composite implantation material and use thereof |
| WO2009152376A1 (en) * | 2008-06-12 | 2009-12-17 | Elixir Medical Corporation | Intravascular stent |
| CN103418035A (en) * | 2013-07-19 | 2013-12-04 | 上海交通大学 | Preparation method of surface coating capable of regulating degradation rate of magnesium alloy intravascular stent |
| CN103889475A (en) * | 2011-08-15 | 2014-06-25 | Meko激光材料加工公司 | Resorbable stents which contain a magnesium alloy |
-
2015
- 2015-05-27 CN CN201510278853.6A patent/CN104873312B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060020331A1 (en) * | 2002-07-12 | 2006-01-26 | Cook Incorporated | Coated medical device |
| CN1857742A (en) * | 2005-04-30 | 2006-11-08 | 中国科学院金属研究所 | Biomedicine implant material with controllable degrading rate and its application |
| CN1919361A (en) * | 2005-08-26 | 2007-02-28 | 中国科学院金属研究所 | Biomedical degradation-absorption-controllable macromolecule metal composite implantation material and use thereof |
| WO2009152376A1 (en) * | 2008-06-12 | 2009-12-17 | Elixir Medical Corporation | Intravascular stent |
| CN103889475A (en) * | 2011-08-15 | 2014-06-25 | Meko激光材料加工公司 | Resorbable stents which contain a magnesium alloy |
| CN103418035A (en) * | 2013-07-19 | 2013-12-04 | 上海交通大学 | Preparation method of surface coating capable of regulating degradation rate of magnesium alloy intravascular stent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106178139A (en) * | 2016-07-05 | 2016-12-07 | 苏州脉悦医疗科技有限公司 | A kind of support and preparation method thereof |
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| CN104873312B (en) | 2017-02-22 |
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