CN104721964B - Method and device for stimulating anterior thalamic nucleus by blue light - Google Patents
Method and device for stimulating anterior thalamic nucleus by blue light Download PDFInfo
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- CN104721964B CN104721964B CN201310699854.9A CN201310699854A CN104721964B CN 104721964 B CN104721964 B CN 104721964B CN 201310699854 A CN201310699854 A CN 201310699854A CN 104721964 B CN104721964 B CN 104721964B
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Abstract
The embodiment of the invention discloses a method of stimulating anterior thalamic nucleus by blue light. The method comprises steps: the surface of a human body is irradiated by red light and infrared light alternatively, and reflecting light signals of the red light and reflecting light signals of the infrared light absorbed by human body tissue are acquired respectively; according to the acquired reflecting light signals of the red light and the acquired reflecting light signals of the infrared light, blood oxygen saturation is calculated, and oxygen partial pressure is calculated according to the obtained blood oxygen saturation; and according to the obtained oxygen partial pressure, blue light of a corresponding frequency is transmitted to stimulate GABA nitrergic nerve fiber of the anterior thalamic nucleus. The embodiment of the invention also discloses a device for stimulating the anterior thalamic nucleus by the blue light. By adopting the method and the device of the invention, the nerve fiber can generate excitement through blue light stimulation, diaphragmatic fatigue does not happened, and the respiratory condition can be more accurately and efficiently regulated and controlled.
Description
Technical field
The present invention relates to a kind of electronic applications, more particularly to a kind of method and device of blue light stimulation nucleus anterior thalami.
Background technology
Breathing is a kind of rhythmic movement, and research at this stage thinks that respiratory rhythm is by respiratory center respiratory nerve cell mass
Generation, participate in respiratory rhythm regulation with improve, the normal breathing movements of body are realized jointly.Due to organ injury such as cardiopulmonary
, to various possible causes such as carbon dioxide sensitivity reductions, respiratory rhythm is subject to broken for exhaustion, trachea blocking, pneumothorax, brain hypertension
It is bad, occur shallow and breathe soon, it is too deep cross slow breathing, asphyxia, Cheyne-Stokes respiration, Sighing respiration etc., respiratory acid can be caused
The serious consequences such as poisoning, alkalosis, respiratory arrest death.Wherein, medicine action-reaction is slow, and can not prevent in advance and real
When regulation and control breathing；Some physical means such as respirator etc. can only temporarily improve breath state, and portability is poor；Using more wide
Although function of the general diaphragm pacing with real-time monitoring and regulation and control, respiratory center is overexcited causes short of breath to cause
Respiratory acidosis, also Sighing respiration is not within the scope of the effect of diaphragm pacemaker.Additionally, persistently stimulating diaphragm
Nerve may cause diaphragmatic fatigue, and respiratory ventilation amount is reduced, and it is not enough to still result in respiratory ventilation, for improving breath state simultaneously
It is undesirable.
The content of the invention
Embodiment of the present invention technical problem to be solved is, there is provided a kind of blue light stimulates the method and dress of nucleus anterior thalami
Put.Can be stimulated by blue light makes nerve fiber produce excitement to adjust breathing state, is not result in diaphragmatic fatigue, regulation and control breathing
State is more accurate effective.
In order to solve above-mentioned technical problem, a kind of method that blue light stimulates nucleus anterior thalami is embodiments provided, bag
Include：
The reflection that human body surface obtains respectively the HONGGUANG after being absorbed by tissue is alternately irradiated by HONGGUANG and infrared light
The reflected light signal of optical signal and infrared light；
Blood oxygen saturation is calculated according to the reflected light signal of the HONGGUANG for getting and the reflected light signal of the infrared light
Degree, according to the calculated blood oxygen saturation partial pressure of oxygen is calculated；
According to the calculated partial pressure of oxygen, launching the blue light of respective frequencies stimulates the GABA energy nerves of nucleus anterior thalami fine
Dimension.
Wherein, the reflected light signal of the reflected light signal of the HONGGUANG that the basis gets and the infrared light is calculated
Blood oxygen saturation includes：The reflected light signal of the reflected light signal of the HONGGUANG for getting and the infrared light is filtered
Processing and amplifying, and it is converted into the voltage signal of HONGGUANG and the voltage signal of infrared light；By the voltage of the HONGGUANG being converted to
The voltage signal of signal and the infrared light is converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light；According to
The digital voltage signal of the HONGGUANG that conversion is obtained and the digital voltage signal of the infrared light calculate the blood oxygen saturation.
Wherein, the blue light of opening stimulates the GABA of nucleus anterior thalami to include before nerve fiber：Photaesthesia ion is led to
Gene C hR2 of road albumen is expelled to nucleus anterior thalami so that can express photaesthesia in nerve fiber in the GABA of the nucleus anterior thalami
Ionophorous protein.
Wherein, described according to the calculated partial pressure of oxygen, launching the blue light of respective frequencies stimulates nucleus anterior thalami
GABA energy nerve fibers include：If the calculated partial pressure of oxygen exceedes pre-set threshold value, launch the blue light thorn of 20HZ frequencies
The GABA for swashing the nucleus anterior thalami can nerve fiber.
Wherein, if the calculated partial pressure of oxygen exceedes pre-set threshold value, launching the blue light of 20HZ frequencies stimulates
The GABA of the nucleus anterior thalami can also include before nerve fiber：Partial pressure of oxygen is sampled, according to the oxygen that sampling gets
Pressure calculates average, standard deviation or the variance of the partial pressure of oxygen；According to the setting of calculated average, standard deviation or variance
Pre-set threshold value.
Correspondingly, the embodiment of the present invention additionally provides a kind of blue light stimulates the device of nucleus anterior thalami, including：
Reflected light acquisition module, for alternately irradiation human body surface to be obtained respectively by tissue by HONGGUANG and infrared light
The reflected light signal of the HONGGUANG after absorption and the reflected light signal of infrared light；
Partial pressure of oxygen computing module, for according to the reflected light signal of the HONGGUANG for getting and the reflection of the infrared light
Optical signal calculates blood oxygen saturation, and according to the calculated blood oxygen saturation partial pressure of oxygen is calculated；
Blue emission module, for according to the calculated partial pressure of oxygen, launching the blue light of respective frequencies to stimulate thalamus
The GABA of pronucleus can nerve fiber.
Wherein, the partial pressure of oxygen computing module includes：Reflected light processing unit, for by the anti-of the HONGGUANG for getting
The reflected light signal for penetrating optical signal and the infrared light is filtered processing and amplifying, and is converted into the voltage signal of HONGGUANG and infrared
The voltage signal of light；Voltage signal processing unit, for by the voltage signal and the infrared light of the HONGGUANG being converted to
Voltage signal be converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light；Saturation computation unit, is used for
The digital voltage signal of the HONGGUANG obtained according to conversion and the digital voltage signal of the infrared light calculate the blood oxygen and satisfy
And degree.
Wherein, described device also includes：Gene injection module, for gene C hR2 of photaesthesia ionophorous protein to be noted
It is mapped to nucleus anterior thalami so that can express photaesthesia ionophorous protein in nerve fiber in the GABA of the nucleus anterior thalami.
Wherein, the blue emission module includes：Transmitter unit is judged, if exceeding for the calculated partial pressure of oxygen
Pre-set threshold value, then launching the blue light of 20HZ frequencies stimulates the GABA energy nerve fibers of the nucleus anterior thalami.
Wherein, the blue emission module also includes：Sampling computing unit, for sampling to partial pressure of oxygen, according to adopting
The oxygen tension meter that sample gets calculates average, standard deviation or the variance of partial pressure of oxygen；Threshold value setting unit, is calculated for basis
Average, standard deviation or variance set the pre-set threshold value.
Implement the embodiment of the present invention, have the advantages that：By HONGGUANG and infrared light, alternately irradiation human body surface divides
The reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light are not obtained, and according to the institute for getting
The reflected light signal of the reflected light signal and the infrared light of stating HONGGUANG calculates blood oxygen saturation, if being calculated according to blood oxygen saturation
The partial pressure of oxygen for obtaining exceeds pre-set threshold value, then launching the blue light of respective frequencies stimulates the GABA energy nerve fibers of nucleus anterior thalami.It is logical
Crossing blue light stimulates the GABA energy nerve fibers of nucleus anterior thalami to be not result in diaphragmatic fatigue, and regulation and control breathing state is more accurate effective.
Description of the drawings
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, can be with
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the method flow diagram that blue light provided in an embodiment of the present invention stimulates nucleus anterior thalami；
Fig. 2 is the structural representation of the device for stimulating nucleus anterior thalami for blue light provided in an embodiment of the present invention；
Fig. 3 is the structural representation of partial pressure of oxygen computing module in embodiment of the present invention device；
Fig. 4 is the structural representation of blue emission module in embodiment of the present invention device.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation is described, it is clear that described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
Fig. 1 is the method flow diagram that blue light provided in an embodiment of the present invention stimulates nucleus anterior thalami, and the embodiment of the present invention is provided
A kind of real-time detection partial pressure of oxygen, and the method for stimulating nucleus anterior thalami according to the partial pressure of oxygen transmitting correspondence blue light for detecting, such as scheme
The shown blue light stimulates the method for nucleus anterior thalami to include：
Step S110, by HONGGUANG and infrared light, alternately irradiation human body surface obtains respectively red after being absorbed by tissue
The reflected light signal of light and the reflected light signal of infrared light.In implementing, when light is by tissue and blood vessel, non-tremulous pulse composition
（Such as skin, muscle, skeleton, venous blood）It is constant to absorb optical signal, and DC component DC is obtained after photelectric receiver；
Tremulous pulse composition（Such as arterial blood）Absorption to optical signal is, as cyclically-varying is made in pulse beating, to obtain after photelectric receiver
To AC compounent AC.Hemoglobin in blood has different absorbances to HONGGUANG and blue light, and the hemoglobin is closed including oxygen
Hb H bO2With reduced hemoglobin Hb, HbO2 Oxyhemoglobins HbO2It is less to 660nm red light absorption amounts, it is infrared to 940nm
Absorbing amount is more；Reduced hemoglobin Hb is then more to 660nm red light absorption amounts, less to 940nm infrared Absorption amounts.Cause
This alternate emission HONGGUANG and infrared light, it is possible to obtain the reflected light direct current signal of HONGGUANG and AC signal, while can obtain red
The reflected light direct current signal of outer light and AC signal, and due to hemoglobin it is different with the absorbance of blue light to HONGGUANG, so
The AC compounent of the HONGGUANG for acquiring is mainly to be reduced the reflected light after Hb H b absorbs, and is acquired
The AC compounent of the infrared light is mainly by HbO2 Oxyhemoglobins HbO2Reflected light after absorption.
Step S120, calculates according to the reflected light signal of the HONGGUANG for getting and the reflected light signal of the infrared light
Blood oxygen saturation, according to the calculated blood oxygen saturation partial pressure of oxygen is calculated.Before blood oxygen saturation is calculated, it is right to need
The reflected light signal of the HONGGUANG for getting and the reflected light signal of the infrared light are processed.In implementing, first
The reflected light signal of the reflected light signal of the HONGGUANG for getting and the infrared light is converted into by optical-electrical converter red
The current signal of light and the current signal of infrared light, are then converted into HONGGUANG by current/voltage conversion circuit by the current signal
Voltage signal and infrared light voltage signal, and the voltage signal of the voltage signal to the HONGGUANG and infrared light filters
Processing and amplifying, is converted into the voltage signal of the voltage signal of the HONGGUANG and the infrared light finally by A/D convertor circuit red
The digital voltage signal of light and the digital voltage signal of infrared light, at the same by alternating current-direct current split circuit be processed into HONGGUANG and
The DC component and AC compounent of infrared light.The digital voltage signal of the HONGGUANG includes DC component Vrdc of HONGGUANG and exchanges
Signal Vrac, the digital voltage signal of the infrared light includes DC component Virdc and AC signal Virac of infrared light.
The digital voltage signal of the HONGGUANG obtained according to conversion and the digital voltage signal of the infrared light calculate institute
State blood oxygen saturation.In implementing, the light intensity of the HONGGUANG absorbance in tissue can be expressed as AC signal Vrac with
The ratio of DC component Vrdc, the light intensity of the infrared light absorbance in tissue can be expressed as AC signal Virac with it is straight
The ratio of flow component Virdc, according to HONGGUANG and infrared light, absorbance can be calculated hemoglobin to red in tissue
The light absorbs ratio R of light and infrared light, the light absorbs ratio R can be expressed as：R=(Vrac/Vrdc)/(Virac/
Virdc)。
The percentage ratio of two kinds of content of hemoglobin just can be calculated according to the light absorbs ratio R.Blood oxygen saturation
Computing formula is as follows：
sp02=A—BR+CR2,（2 represent R square）In formula, A, B, C are scaling constant, can be obtained by scaling experiment.
After blood oxygen saturation is calculated, can be calculated with oxygen saturation curve according to oxygen dissociation curve or partial pressure of oxygen
The partial pressure of oxygen of current brain, what the oxygen dissociation curve reflected is the relation between blood oxygen saturation and partial pressure of oxygen, and axis of ordinates is
Blood oxygen saturation, axis of abscissas is partial pressure of oxygen, can be by the blood oxygen saturation in oxygen dissociation curve and the corresponding relation of partial pressure of oxygen
Obtain partial pressure of oxygen.
Step S130, according to the calculated partial pressure of oxygen, launching the blue light of respective frequencies stimulates nucleus anterior thalami
GABA can nerve fiber.Transmitting blue light stimulates before the GABA energy nerve fibers of nucleus anterior thalami, needs photaesthesia ion channel
Gene C hR2 of albumen is expelled to nucleus anterior thalami so that the GABA of the nucleus anterior thalami can express in nerve fiber photaesthesia from
Subchannel albumen.In implementing, if the calculated partial pressure of oxygen of step S120 exceeds pre-set threshold value, transmitting 20HZ frequencies
The blue light of rate stimulates the GABA energy nerve fibers of the nucleus anterior thalami.During nucleus anterior thalami is stimulated by blue light, need
HONGGUANG and Infrared irradiation human body surface are opened simultaneously with the blood oxygen saturation of real-time detection brain, when the blood oxygen for detecting brain
When saturation returns to normal condition, then stopping transmitting blue light stimulates the GABA energy nerve fibers of nucleus anterior thalami.Wherein, HONGGUANG and
Infrared light is to irradiate human body surface with the tranmitting frequency of 200HZ, and blue light is the GABA for stimulating nucleus anterior thalami with 20HZ tranmitting frequencies
Can nerve fiber.
Wherein, step S130 also includes sampling partial pressure of oxygen, and according to the oxygen tension meter that sampling gets oxygen is calculated
The average of pressure, standard deviation or variance, according to calculated average, standard deviation or variance the pre-set threshold value is set.Partial pressure of oxygen
Normal range is 95～100mmHg, but the value can reduce with advancing age.Simultaneously regional differences are big, different regions
Range of normal value is different, and current most domestic area 80～100mmHg of conventional range of normal value, highlandss are relatively low, typically
For 60～80mmHg.Blood oxygen saturation general less than 94% regards as anaerobic condition, is clinically judged with 90% as boundary.
In order to be directed to the difference of different people physical condition, set pre-set threshold value when, need to carry out real-time sampling to partial pressure of oxygen, it is laggard
Row statistical analysiss, calculate the statistical parameters such as average, standard deviation or the variance of partial pressure of oxygen, according to the default threshold of parameter setting partial pressure of oxygen
Value, such as sets 3 times of standard deviations as pre-set threshold value, when the partial pressure of oxygen is detected more than the pre-set threshold value, i.e., regarding the partial pressure of oxygen
In abnormal state.Particularly, the embodiment of the present invention directly can carry out threshold values setting by the use of blood oxygen saturation as parameter
And feedback.
Optionally, the nucleic acid of cell specific promoter and encoded light sensitive ion channel albumen is carried by direct injection
The slow virus carrier of sequence, can deliver to nucleus anterior thalami so as in nucleus anterior thalami by gene C hR2 of photaesthesia ionophorous protein
GABA can expression in nerve fiber.ChR2 albumen is a kind of rhodopsin, originates from unicellular class chlorella Chlamydomonas reinhardtii.Research
It was found that, ChR2 gene code photoactivation type ionophorous proteins when the albumen is stimulated by blue light, will open ion channel, make
Obtain cell potential depolarization excited, produce action potential.By biotechnology, can be in mammal cell membranes in tissue surface table
Up to the albumen, when the cell for expressing the protein gene is subject to the blue light of 472nm wavelength to stimulate, stream in extracellular cation can be made and made
Cell depolarization, excitatory cells activity.And the light of the wavelength does not have an impact to other neuron normal functions in brain, will not band
Carry out other side effect.
Optionally, digital voltage signal is processed in the embodiment of the present invention, blood oxygen saturation is calculated, is controlled transmitting infrared light and red
Light, blue light can adopt the very little PIC10F series monolithics of the volume that MICROCHIP is released, and it is smart that the single-chip microcomputer is equipped with 4MHz
Really built-in agitator, 33 instructions, two layer stacks, (100 receive for 25 milliamperes of input/output electric current I/O, low-power consumption standby currents
Peace), the wide operating voltage range by 2 to 5.5V, 8 bit clock, monitoring clock (Watchdog Timer).In the single-chip microcomputer
There are 3 I/O pins with independent, direction control function, two of which I/O mouth can be adopted to control the unlatching of HONGGUANG and infrared light
With closing, I/O controls the open and close of blue light, also one input pin, receives HONGGUANG through processing and red
The digital voltage signal of outer light.Wherein, the regulation and control of light frequency are timed tune using the accurate built-in agitators of 4MHz in single-chip microcomputer
Control.
Fig. 2 is the structural representation of the device for stimulating nucleus anterior thalami for blue light provided in an embodiment of the present invention.The light
Stimulating the device of nucleus anterior thalami includes：Reflected light acquisition module 210, partial pressure of oxygen computing module 220 and blue emission module
230, wherein：
Reflected light acquisition module 210, for alternately irradiation human body surface to be obtained respectively by human body by HONGGUANG and infrared light
The reflected light signal of the HONGGUANG after tissue resorption and the reflected light signal of infrared light.Specifically, it is non-when light is by tissue and blood vessel
Tremulous pulse composition（Such as skin, muscle, skeleton, venous blood）It is constant to absorb optical signal, obtains straight after photelectric receiver
Flow component DC；Tremulous pulse composition（Such as arterial blood）Absorption to optical signal is as cyclically-varying is made in pulse beating, through photoelectricity
AC compounent AC is obtained after receptor.Hemoglobin in blood has different absorbances, the blood red egg to HONGGUANG and blue light
Include HbO2 Oxyhemoglobins HbO in vain2With reduced hemoglobin Hb, HbO2 Oxyhemoglobins HbO2It is less to 660nm red light absorption amounts,
It is more to 940nm infrared Absorption amounts；Reduced hemoglobin Hb is then more to 660nm red light absorption amounts, and 940nm infrared lights are inhaled
Receipts amount is less.Therefore alternate emission HONGGUANG and infrared light, it is possible to obtain the launching light direct current signal of HONGGUANG and AC signal, while
The launching light direct current signal and AC signal of infrared light can be obtained, and because hemoglobin is to HONGGUANG and the absorbance of blue light
Difference, so the AC compounent of the HONGGUANG for acquiring is mainly to be reduced the reflected light after Hb H b absorbs,
The AC compounent of the infrared light for acquiring is mainly by HbO2 Oxyhemoglobins HbO2Reflected light after absorption.
Partial pressure of oxygen computing module 220, the reflected light letter of the HONGGUANG for being got according to reflected light acquisition module 210
Number and the reflected light signal of the infrared light calculate blood oxygen saturation, oxygen is calculated according to the calculated blood oxygen saturation
Pressure.Before blood oxygen saturation is calculated, the reflected light signal of the HONGGUANG to getting and the reflection of the infrared light are needed
Optical signal is processed.The partial pressure of oxygen computing module 220 includes：Reflected light processing unit 321, voltage signal processing unit
322 and saturation computation unit 323, wherein：
Reflected light processing unit 321, the reflected light signal of the HONGGUANG for reflected light acquisition module 210 to be got
Processing and amplifying is filtered with the reflected light signal of the infrared light, and is converted into the voltage signal of HONGGUANG and the voltage of infrared light
Signal.Specifically, first by optical-electrical converter by the reflected light signal of the HONGGUANG and the reflected light signal of the infrared light
The current signal of HONGGUANG and the current signal of infrared light are converted into, are then turned the current signal by current/voltage conversion circuit
The voltage signal of HONGGUANG and the voltage signal of infrared light are changed into, finally by voltage signal of the filter amplification circuit to the HONGGUANG
Filtration processing and amplifying is carried out with the voltage signal of infrared light.
Voltage signal processing unit 322, the voltage letter of the HONGGUANG for reflected light processing unit 321 to be converted to
Number and the voltage signal of the infrared light be converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light.Specifically
, the voltage signal of the voltage signal of the HONGGUANG and the infrared light can be converted into the number of HONGGUANG by A/D convertor circuit
The digital voltage signal of word voltage signal and infrared light, while being processed as the straight of HONGGUANG and infrared light by alternating current-direct current split circuit
Flow component and AC compounent.
Saturation computation unit 323, the numeral of the HONGGUANG for being obtained according to the conversion of voltage signal processing unit 322
The digital voltage signal of voltage signal and the infrared light calculates the blood oxygen saturation.The digital voltage signal bag of the HONGGUANG
DC component Vrdc and AC signal Vrac of HONGGUANG are included, the digital voltage signal of the infrared light includes the direct current of infrared light
Component Virdc and AC signal Virac.Specifically, the light intensity of HONGGUANG absorbance in tissue can be expressed as exchange letter
The ratio of number Vrac and DC component Vrdc, the light intensity of the infrared light absorbance in tissue can be expressed as AC signal
The ratio of Virac and DC component Virdc, according to HONGGUANG and infrared light in tissue absorbance can be calculated it is blood red
Albumen can be expressed as to HONGGUANG and the light absorbs ratio R of infrared light, the light absorbs ratio R：
R=(Vrac/Vrdc)/(Virac/Virdc)
The percentage ratio of two kinds of content of hemoglobin just can be calculated according to the light absorbs ratio R.Blood oxygen saturation
Computing formula is as follows：
sp02=A—BR+CR2,（2 represent R square）In formula, A, B, C are scaling constant, can be obtained by scaling experiment.
After blood oxygen saturation is calculated, can be calculated with oxygen saturation curve according to oxygen dissociation curve or partial pressure of oxygen
The partial pressure of oxygen of current brain, what the oxygen dissociation curve reflected is the relation between blood oxygen saturation and partial pressure of oxygen, and axis of ordinates is
Blood oxygen saturation, axis of abscissas is partial pressure of oxygen, can be by the blood oxygen saturation in oxygen dissociation curve and the corresponding relation of partial pressure of oxygen
Obtain partial pressure of oxygen.
Blue emission module 230, for according to the calculated partial pressure of oxygen of partial pressure of oxygen computing module 220, it to be right to launch
Answer the GABA energy nerve fibers of the blue light stimulation nucleus anterior thalami of frequency.Transmitting blue light stimulates the GABA energy nerve fibers of nucleus anterior thalami
Before, need for gene C hR2 of photaesthesia ionophorous protein to be expelled to nucleus anterior thalami so that in the nucleus anterior thalami
GABA can express photaesthesia ionophorous protein in nerve fiber.Specifically, if the calculated institute of partial pressure of oxygen computing module 220
Partial pressure of oxygen is stated beyond pre-set threshold value, then launching the blue light of 20HZ frequencies stimulates the GABA energy nerve fibers of the nucleus anterior thalami.
During stimulating nucleus anterior thalami by blue light, need to launch HONGGUANG simultaneously and Infrared irradiation human body surface is big with real-time detection
The blood oxygen saturation of brain, when the blood oxygen saturation for detecting brain returns to normal condition, then stopping transmitting blue light stimulates mound
The GABA of brain pronucleus can nerve fiber.Wherein, HONGGUANG and infrared light are to irradiate human body surface, blue light with the tranmitting frequency of 200HZ
It is the GABA energy nerve fibers that nucleus anterior thalami is stimulated with 20HZ tranmitting frequencies.
The blue emission module 230 also includes sampling computing unit 431 and threshold value setting unit as shown in Figure 4
432, wherein：
Sampling computing unit 431, for sampling to partial pressure of oxygen, according to the oxygen tension meter that sampling gets oxygen is calculated
The average of pressure, standard deviation or variance.Specifically, partial pressure of oxygen normal range is 95～100mmHg, but the value can be with the increasing at age
Grow and reduce.Simultaneously regional differences are big, and different regions range of normal value is different, and current most domestic area is conventional normal
Value 80～100mmHg of scope, highlandss are relatively low, generally 60～80mmHg.Blood oxygen saturation general less than 94% is regarded as lacking
Oxygen condition, is clinically judged with 90% as boundary.In order to be directed to the difference of different people physical condition, in setting pre-set threshold value
When, need to carry out real-time sampling to partial pressure of oxygen, statistical analysiss are carried out afterwards, calculate average, standard deviation or the side of the partial pressure of oxygen
The statistical parameters such as difference.
Threshold value setting unit 432, for according to the average of the calculated partial pressure of oxygen of sampling computing unit 431, mark
Quasi- difference or variance set the pre-set threshold value.3 times of standard deviations are for example set as pre-set threshold value, is exceeded when the partial pressure of oxygen is detected
During the pre-set threshold value, i.e., it is in abnormal state regarding the partial pressure of oxygen.
Optionally, the nucleic acid of cell specific promoter and encoded light sensitive ion channel albumen is carried by direct injection
The slow virus carrier of sequence, can deliver to nucleus anterior thalami so as in nucleus anterior thalami by gene C hR2 of photaesthesia ionophorous protein
GABA can expression in nerve fiber.ChR2 albumen is a kind of rhodopsin, originates from unicellular class chlorella Chlamydomonas reinhardtii.Research
It was found that, ChR2 gene code photoactivation type ionophorous proteins when the albumen is stimulated by blue light, will open ion channel, make
Obtain cell potential depolarization excited, produce action potential.By biotechnology, can be in mammal cell membranes in tissue surface table
Up to the albumen, when the cell for expressing the protein gene is subject to the blue light of 472nm wavelength to stimulate, stream in extracellular cation can be made and made
Cell depolarization, excitatory cells activity.And the light of the wavelength does not have an impact to other neuron normal functions in brain, will not band
Carry out other side effect.
Optionally, digital voltage signal is processed in the embodiment of the present invention, blood oxygen saturation is calculated, is controlled transmitting infrared light and red
Light, blue light can adopt the very little PIC10F series monolithics of the volume that MICROCHIP is released, and it is smart that the single-chip microcomputer is equipped with 4MHz
Really built-in agitator, 33 instructions, two layer stacks, (100 receive for 25 milliamperes of input/output electric current I/O, low-power consumption standby currents
Peace), the wide operating voltage range by 2 to 5.5V, 8 bit clock, monitoring clock (Watchdog Timer).In the single-chip microcomputer
There are 3 I/O pins with independent, direction control function, two of which I/O mouth can be adopted to control the unlatching of HONGGUANG and infrared light
With closing, I/O controls the open and close of blue light, also one input pin, receives HONGGUANG through processing and red
The digital voltage signal of outer light.Wherein, the regulation and control of light frequency are timed tune using the accurate built-in agitators of 4MHz in single-chip microcomputer
Control.
Embodiments providing a kind of blue light stimulates the method and device of nucleus anterior thalami, is handed over by HONGGUANG and infrared light
The reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light are obtained respectively for irradiation human body surface,
And the reflected light signal of the reflected light signal according to the HONGGUANG for getting and the infrared light calculates blood oxygen saturation, if root
The partial pressure of oxygen for obtaining is calculated according to blood oxygen saturation beyond pre-set threshold value, then launching the blue light of respective frequencies stimulates nucleus anterior thalami
GABA can nerve fiber.The GABA energy nerve fibers of nucleus anterior thalami are stimulated to be not result in diaphragmatic fatigue, regulation and control breathing by blue light
State is more accurate effective.
One of ordinary skill in the art will appreciate that realizing all or part of flow process in above-described embodiment method, can be
Related hardware is instructed to complete by computer program, described program can be stored in a computer read/write memory medium
In, the program is upon execution, it may include such as the flow process of the embodiment of above-mentioned each method.Wherein, described storage medium can be magnetic
Dish, CD, read-only memory（Read-Only Memory, ROM）Or random access memory（Random Access
Memory, RAM）Deng.
Above disclosed is only present pre-ferred embodiments, can not limit the right model of the present invention with this certainly
Enclose, therefore the equivalent variations made according to the claims in the present invention, still belong to the scope that the present invention is covered.
Claims (4)
1. a kind of blue light stimulates the device of nucleus anterior thalami, it is characterised in that described device includes：
Reflected light acquisition module, is absorbed for alternately being irradiated human body surface and being obtained respectively by HONGGUANG and infrared light by tissue
The reflected light signal of HONGGUANG afterwards and the reflected light signal of infrared light；
Partial pressure of oxygen computing module, for according to the reflected light of the reflected light signal of the HONGGUANG for getting and infrared light letter
Number blood oxygen saturation is calculated, partial pressure of oxygen is calculated according to the calculated blood oxygen saturation；
Gene injection module, for gene C hR2 of photaesthesia ionophorous protein to be expelled to into nucleus anterior thalami so that described
The GABA of nucleus anterior thalami can express photaesthesia ionophorous protein in nerve fiber；
Blue emission module, for according to the calculated partial pressure of oxygen, launching the blue light of respective frequencies to stimulate nucleus anterior thalami
GABA can nerve fiber.
2. blue light as claimed in claim 1 stimulates the device of nucleus anterior thalami, it is characterised in that the partial pressure of oxygen computing module bag
Include：
Reflected light processing unit, for by the reflected light signal of the reflected light signal of the HONGGUANG for getting and the infrared light
Processing and amplifying is filtered, and is converted into the voltage signal of HONGGUANG and the voltage signal of infrared light；
Voltage signal processing unit, for by the voltage signal of the voltage signal of the HONGGUANG being converted to and the infrared light
It is converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light；
Saturation computation unit, for according to the digital voltage signal and the numeral of the infrared light for converting the HONGGUANG for obtaining
Voltage signal calculates the blood oxygen saturation.
3. blue light as claimed in claim 1 stimulates the device of nucleus anterior thalami, it is characterised in that the blue emission module bag
Include：
Judge transmitter unit, if exceeding pre-set threshold value for the calculated partial pressure of oxygen, launch the blue light of 20HZ frequencies
Stimulate the GABA energy nerve fibers of the nucleus anterior thalami.
4. blue light as claimed in claim 3 stimulates the device of nucleus anterior thalami, it is characterised in that the blue emission module is also wrapped
Include：
Sampling computing unit, for sampling to partial pressure of oxygen, according to the oxygen tension meter that sampling gets the partial pressure of oxygen is calculated
Average, standard deviation or variance；
Threshold value setting unit, for setting the pre-set threshold value according to calculated average, standard deviation or variance.
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| US5353790A (en) * | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
| CN201404597Y (en) * | 2009-05-31 | 2010-02-17 | 徐州安诺休闲设备有限公司 | Far infrared dry steaming foot sauna barrel |
| CN202821367U (en) * | 2012-10-25 | 2013-03-27 | 北京超思电子技术股份有限公司 | Multi-functional blood oxygen instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5353790A (en) * | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
| CN201404597Y (en) * | 2009-05-31 | 2010-02-17 | 徐州安诺休闲设备有限公司 | Far infrared dry steaming foot sauna barrel |
| CN202821367U (en) * | 2012-10-25 | 2013-03-27 | 北京超思电子技术股份有限公司 | Multi-functional blood oxygen instrument |
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