CN104706562B - A kind of Chinese herbal medicine whitening cream and preparation method thereof - Google Patents
A kind of Chinese herbal medicine whitening cream and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of Chinese herbal medicine whitening cream, including the extracts of Chinese herbal medicine for suppressing melanin generation, surfactant, propane diols, glyceryl stearate, vaseline and water, the mass ratio of extracts of Chinese herbal medicine, surfactant, propane diols, glyceryl stearate, vaseline and water is 10 ~ 15：20~30：30~50：20~30：40~60：100 ~ 150, the bulk drug of the extracts of Chinese herbal medicine includes reticulate millettia, rhizoma atractylodis, Chinese gall, Selaginella tamariscina, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis, rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, plays both sides of the street and adenophora tetraphylla.The present invention can realize suppressing the generation of melanin, meanwhile, it is docile to skin nursing, strong stimulation will not be produced, infringement skin is in itself.
Description
Technical field
The invention belongs to chemical field, more particularly to a kind of cosmetics, specifically a kind of Chinese herbal medicine whitening cream and its
Preparation method.
Background technology
Change by the physiological whitening that physical covering whitening is reduced to melanin from 20 century 70s, people couple
There is the change of essence in the idea of skin-whitening.Whitening function is inseparable with melanin, and melanin is first in table
Scytoblastema bottom is generated, and is then transferred to keratinocyte along the dendron of melanocyte, with the metabolic gradually heap of keratinocyte
Product causes melanin deposition in epidermis, therefore can be generated by suppressing melanin, suppresses melanin transmission, smashes melanin
Whitening is realized with cleaning cortex.The activity of tyrosinase can be suppressed using biological agent, herbal development, melanin shape is prevented
Into the physiological skin-lightening cosmetic of safe and effective removal skin splash, is the key areas of 21 century beauty science.
Traditional cosmetics often contain the chemically composition such as acid, alkali, salt, surfactant.These chemical substances are acted on
In, through often causing irritant skin lesion, dermatitis being contacted as excitant after skin, mucous membrane of organ etc., cause skin lesion,
Also local skin is made to occur inflammation rapidly.
Chinese herbal medicine is the important treasure-house that Ancient Times in China doctor leaves descendant for, and China is rising for Traditional Chinese Medicine Chinese medicine
Ground, oneself has the history of more than 3,000 years for application to Chinese herbal medicine in terms of health and beauty, in successive dynasties medical science classical works, such as Warring states
Phase《The Classic of Mountains and Rivers》, Qin Han thes period of Three Kingdoms《Sheng Nong's herbal classic》, the Tang Dynasty Sun Si satisfies《Qianjin Yi Fang》, Song dynasty Chen Zhao meet, king
Bosom is hidden etc. to write《Peaceful holy benevolent prescriptions》, famous pharmacy man of Ming Dynasty Li Shizhen (1518-1593 A.D.)《Compendium of Materia Medica》, Qing Dynasty Zhang Lu《Prescriptions worth thousand gold is spread out
Justice》, Zhao Xuemin《Herbal guiding principle day is picked up any lost article from the road》Etc. the special piece of beauty is designed with, there is deep elaboration from theory into action, and compile
The example and formula of a large amount of Chinese medicine beautifying face and moistering lotions.Chinese medicine beauty content vastness is extensive in ancient medical book, is that ancestors are left to existing
For the treasure of people.
Chinese herbal medicine can reach reduction by lowering the links such as tyrosinase cdna expression, zymoprotein synthesis, oxidation activity
The effect of melanin genesis.Many this center target spots around tyrosinase of many research work now launch, and also have scholar to note
Anticipate to other links of metabolism of pigment.
The content of the invention
For above-mentioned technical problem of the prior art, the invention provides a kind of Chinese herbal medicine whitening cream and its preparation side
Method, described this Chinese herbal medicine whitening cream and preparation method thereof solve cosmetics of the prior art and often cause excitant skin
Skin lesion, dermatitis is contacted as excitant, causes skin lesion, local skin is occurred the technical problem of inflammation rapidly.
A kind of Chinese herbal medicine whitening cream of the present invention, including for suppressing extracts of Chinese herbal medicine, the surface-active of melanin generation
Agent, propane diols, glyceryl stearate, vaseline and water, extracts of Chinese herbal medicine, surfactant, propane diols, glycerol stearate
The mass ratio of fat, vaseline and water is 10~15：20~30：30~50：20~30：40~60：100~150, the Chinese herbal medicine
The bulk drug of extract solution includes reticulate millettia, rhizoma atractylodis, Chinese gall, Selaginella tamariscina, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis, red scape
My god, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, play both sides of the street and adenophora tetraphylla, it is the reticulate millettia, grey
Art, Chinese gall, Selaginella tamariscina, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis, rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma,
Hairy euphorbia, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, to play both sides of the street with the weight ratio of adenophora tetraphylla be 30~40：10~20：15~25：10~20：10
~20：20~30：25~35：10~20：10~20：15~25：45~55：15~25：10~20,：15~25：10~20：
10~20：25~35：15~25：5~15：10~20.
Further, the reticulate millettia, rhizoma atractylodis, Chinese gall, Selaginella tamariscina, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis,
Rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, playing both sides of the street with the weight ratio of adenophora tetraphylla is
33~37：13~17：18~22：13~17：13~17：23~27：28~32：13~17：13~17：18~22：48~52：
18~22：13~17：18~22：13~17：13~17：28~32：18~22：8~12：13~17.
Further, the reticulate millettia, rhizoma atractylodis, Chinese gall, Selaginella tamariscina, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis,
Rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, playing both sides of the street with the weight ratio of adenophora tetraphylla is
35：15：20：15：15：25：30：15：15：20：50：20：15：20：15：15：30：20：10：15.
Further, the surfactant is Gemini surface active agent, and its hydrophobic base section is by epoxy resin segment shape
Into polymer has below general formula：
X, y, z are the integer from 1 to 5, and R is methyl, ethyl or benzyl, and E represents epoxy resin, and its structure can table
It is shown as：
M is the integer from 1 to 5.
Further, described epoxy resin is E51.
Further, first organic solvent is the combination of one or more in C1~C3 alcohol, described asphalt mixtures modified by epoxy resin
Fat is 2.0 with the weight ratio of organic solvent:1~4.0:1.
Further, described polyamines be ethylenediamine, diethylenetriamine, triethylene tetramine or TEPA, it is described
The second organic solvent be one or more in C1~C3 alcohol, the weight ratio of polyamines and the second organic solvent is 1.0:1~
2.0:1。
Further, the ratio between molal quantity of the molal quantity of epoxy and polyamines is 1 in the epoxy resin:1.2~1.8.
Further, described phosphorous acid and the mol ratio of nitrogen-atoms in polyamines are 1.1~1.5:1, formaldehyde and phosphorous acid
Mol ratio be 1.2~1.8:1, hydrochloric acid is 1.0~3.0 with the mol ratio of phosphorous acid:1, nitrogen-atoms in NaOH and polyamines
Mol ratio be 1.0:1.
Further, the preparation method of described Gemini surface active agent is comprised the following steps：
The first step, one the step of prepare epoxy resin many amine polymers, epoxy resin is added in a reactor, plus
Enter the dissolving of the first organic solvent, obtain epoxy resin solution, polyamines is dissolved in the second organic solvent, the polyamines that will be obtained is molten
Liquid is added drop-wise in epoxy resin again, completion of dropping, and stirring is depressurized after 1-2 hours and boils off solvent, obtains the polymerization of epoxy resin polyamines
Thing；
Second step, one the step of prepare phosphate Gemini surface active agent, adds toward many amine polymers of epoxy resin
Phosphorous acid and hydrochloric acid, are warming up to 70~80 DEG C, and formalin is added dropwise toward system, and stirring is cooled down after 1~2 hour, there is insoluble matter
Separate out, pour out clear liquid, with vigorous stirring, sodium hydroxide solution is added dropwise toward system the inside, system is clarified and obtains phosphate gradually
Gemini surface active agent solution.
Present invention also offers a kind of preparation method of above-mentioned Chinese herbal medicine whitening cream, comprise the following steps：
The first step, prepares the extracts of Chinese herbal medicine；
Second step, each material is weighed according to weight ratio, and vaseline, tristerin, surfactant are placed in into one
In container, melting is heated to, temperature is maintained at 85-95 DEG C, obtains oil phase；
3rd step, extracts of Chinese herbal medicine is scattered in propane diols, adds water, and stirring to be allowed to disperse, and is then heated to
60~70 DEG C, 30~60min of stirring and dissolving to transparent clarification shape stands to remove blibbing；30~40 DEG C are cooled to, treat molten
The transparent fluid viscosity increase of solution starts in emulsion form, and the oil phase for adding second step to obtain continues to stir 30~45min, stands 12
Paste finished product is obtained final product after~24h.
Further, the preparation method of the extracts of Chinese herbal medicine is comprised the following steps：
The first step, bulk drug is crushed respectively, is put into a container and is mixed, and obtains mixture, adds 8~10 times
The distilled water of mixture quality, after 5~6h of immersion, 3~4h is boiled in heating, filters, and obtains first time filtered fluid；
Second step, adds 6~8 times of distilled water of the quality of mixture again in the filter residue that filtering is obtained, and heating boils 2
~3h, second filtering, obtains second filtered fluid；
3rd step, 4~6 times of distilled water of the quality of mixture are added in the filter residue that second filtering is obtained, and are heated
1~2h is boiled, third time is filtered, and obtains third time filtered fluid；
4th step, merges above-mentioned three filtered fluids, filters again, obtains filtrate, is concentrated to give extracts of Chinese herbal medicine.
Each bulk drug pharmacology is as follows：
Reticulate millettia：Latin name spatholobi caulis, it is bitter, sweet, it is warm in nature, return liver and kidney channel, with expansion of blood vessels, mend
Blood is invigorated blood circulation, menstruation regulating, the effect stimulated the circulation of the blood and cause the muscles and joints to relax, and curing mainly the deficiency of blood has the irregular menstruation of silt, and limbs pain is meciless, soreness and weakness of waist and knees, pain
Deng card.
Rhizoma atractylodis：Taste is pungent, hardship, it is warm in nature, enter spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and eliminating dampness, the effect of improving eyesight is main to use
In the stomachache rush down dysentery of damp retention in middle-jiao, incoordination between the spleen and the stomach abdominal distension pain is vomitted indigestion and loss of appetite；The abdomen side of body distending pain of liver-stomach disharmony, vomiting with acid regurgitation；
And the card such as wind-cold-dampness arthralgia of strongly fragrant channels and collaterals outside cold-dampness.
Chinese gall：Latin name Galla Chinensis, sour, puckery, cold in nature, return lung, large intestine, kidney channel are solid with convergence
Puckery, nourishing generate fluid, effect of kidney calming, cure mainly：Chronic cough of deficiency lung；Spontaneous sweating；Protracted dysentery chronic diarrhea；Prolapse of the anus；Seminal emission；Gonorrhoea；Respectively
Plant bleeding；Carbuncle swells sore rhizoma atractylodis furuncle etc. is demonstrate,proved.
Selaginella tamariscina：Latin name Selaginellae Herba, are that Spikemoss plant Selaginella tamariscina or Selaginella pulvinata dry herb, taste
Pungent, mild-natured, Return liver, the heart channel of Hang-Shaoyin have functions that invigorate blood circulation, and for closed dysmenorrhea , wei lump in the abdomen lump in the abdomens, injury from falling down is spitted blood, collapsed
Leakage, has blood in stool, the card such as prolapse of the anus.
Sea-buckthorn：It is sour；It is puckery；It is warm in nature, with relieving cough and reducing sputum；Stomach strengthening and digestion promoting；Effect of promoting blood circulation to remove blood stasis.Cure mainly coughing with a lot of sputum；
Pulmonary abscess；Indigestion；Dyspeptic abdominalgia；Stomachache；Enteritis；Amenorrhoea；The card such as beat the stasis of blood swell.
Semen Cuscutae：Sweet, pungent, mild-natured, enter liver, kidney, the spleen channel have tonifying kidney and benefiting sperm, and the effect for nourishing the liver to improve visual acuity cures mainly kidney yang not
The impotence of foot, premature ejaculation of passing out semen, frequent urination, dizziness and tinnitus, kidney deficiency Low Back Pain, married woman's under band, nausea is not solid, both liver and kidney deficiency, liver blood
The binocular of deficiency is dim-sighted, blurring of vision, the loose stool stomachache of speen-kidney dificiency, the card such as diarrhea with undigested food.
Sealwort：Latin name Polygonati Rhizoma, it is sweet, it is mild-natured, enter lung, spleen, kidney channel, with enriching qi and yin, it is good for
Spleen moistening lung, effect of enriching kidney essence, for taste deficiency of qi and yin, deficiency of food is powerless, the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, yin asthenia generating intrinsic heat it
Quench one's thirst, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Coix seed：It is cool in nature, sweet, light, returns spleen, stomach, lung channel.With invigorating the spleen excreting dampness, clearing away heat and eliminating pus, eliminating impediment, Li Shui work(
Can, for weakness of the spleen and the stomach, loose stool diarrhoea, or vaginal discharge diseases of women, insufficiency of the spleen with overabundance of dampness oedema, difficult urination, or tinea pedis swells and ache；Damp-heat arthralgia
Bitterly, brothers' contraction, miserable pain；Lung carbuncle coughs saliva phlegm, or enterodynia arrested anxious stomachache.
Dicliptera chinensis：It is the herb of Acanthaceae Dicliptera chinensis platymiscium Dicliptera chinensis, sweet, slight bitter is cold in nature, the thoughts of returning home, liver, lung channel,
With heat-clearing, cool blood, dampness removing, effect of removing toxic substances cures mainly cold, fever, and pyreticosis hair spot is had blood in stool, hematuria, uterine bleeding, cough with lung heat,
Abscess of throat, the hot hot eyes of liver, child convulsion, dribbling urination, under band, snake dog bite etc. are demonstrate,proved.
Chicken muscle is joined：It is mildly bitter flavor, sweet for Rubiaceae Damnacamthus indicus platymiscium comes into leaves the root of beads tree, it is mild-natured, with invigorating QI and blood,
Effect of astringing to arrest bleeding, cures mainly the card such as women's snowslide, discharging fresh blood stool, weak deficiency of blood.
Hot miliaria grass：Taste is pungent, hardship, slightly warm in nature, with driving away summer heat is delivered, dampness removing dissipates the antipruritic effect of wind with, cures mainly chill sense
Emit, yin summer-heat syndrome headache, nauseous wrist bitterly, dysentery, oedema, hemorrhoid blood, pruritus vulvae eczema, traumatism and bleeding, the card such as snake bite and insect sting.
Asian puccoon：It is cold in nature, sweet, salty, the thoughts of returning home, Liver Channel, with cooling and activating blood, the effect for promoting eruption of detoxifying.For blood-heat and toxin exuberance,
Atropurpureus macula, measles without adequate eruption, sore, eczema, scald.Clearing heat and cooling blood, for measles, pyreticosis ecchymosis, eczema, hematuria, blood
Drench, bloody flux, sore, erysipelas, burn, the card such as constipation with heat retention.
Dioscoreae septemlobae,rhizoma：Latin name Dioscoreae Spongiosae Rhizoma, mild-natured, bitter returns kidney, stomach, with profit
It is wet to go turbid, effect for wind and relieving paralysis of dispelling, for the card such as gonorrhoea gonorrhoea, leukorrhea, damp and hot sore, waist and knee numbness pain.
Hairy euphorbia：Latin name Euphorbiae Hirate Herba, mildly bitter flavor, micro- acid are cool in nature, with clearing heat and detoxicating, profit
Wet antipruritic effect, for bacillary dysentery, amoebic dysentery, enteritis, enteron aisle trichomonad, indigestion, bronchitis, renal plevis kidney
It is scorching；The card such as eczema, dermatitis, pruitus is controlled in external application.
Agalloch eaglewood：Taste is pungent, hardship, warm in nature, returns spleen, stomach, kidney, lung channel, with sending down abnormally ascending middle benefit gas, warm kidney receives effect of gas, cures mainly gas
It is inverse to pant, hiccup is vomitted, abdominal distention, waist and knee void is cold, and large intestine void is secret, and urine gas drenches, the card such as man's cold sperm.
Cattail pollen：It is sweet, mild-natured, enter liver, pericardium channel, with hemostasis, stagnation resolvation, treating stranguria effect.For spitting blood, bleeding from five sense organs or subcutaneous tissue is coughed up
Blood, uterine bleeding, traumatism and bleeding, closed dysmenorrhea, gastral cavity abdomen shouting pain, tumbling and swelling, blood strangury and dry pain etc. are demonstrate,proved.
Caulis bambusae in taenian：Cold nature, it is sweet, attach to the lung and stomach meridians, with clearing heat and eliminating phlegm, the effect for relieving restlessness and preventing vomiting, for phlegm-heat cough,
Courage fire holds the card such as phlegm, dysphoria with smothery sensation vomiting, insomnia of palpitating with fear, middle wind phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pernicious vomiting, fetal irritability under the arm.
Play both sides of the street：Latin name Liquidambaris Fructus, bitter is mild-natured, Return liver, kidney channel, with dispelling, collateral-activating,
Effect of Li Shui stimulates the menstrual flow, for joint pain, numbness contracture, oedema turgor, the newborn card such as Amenorrhea less.
Adenophora tetraphylla：Sweet, slight bitter, cold nature enters lung, stomach, moistens the lung and relieve the cough, and the effect of nourishing the stomach to improve the production of body fluid is mainly used in
The few phlegm of the lung-dryness syndrome due to yin deficiency, dry cough, labor are coughed phlegm blood, and deficiency of stomach-Yin, mouthfeel are swallowed the cards such as the red few tongue of dry, constipation, tongue, can improve cell
Immune and non-specific immunity, suppresses humoral immunity, the function with regulation immunologic balance.
The present invention is compared with prior art, and its technological progress is significant.The present invention utilizes theory of traditional Chinese medical science, in proposition one kind
Herbal medicine whitening cream, realizes suppressing the generation of melanin, meanwhile, it is docile to skin nursing using Chinese herbal medicine whitening, will not produce strong
Stimulate, infringement skin is in itself.
Brief description of the drawings
Fig. 1：The infrared spectrum of surfactant.
Specific embodiment
The invention provides a kind of Chinese herbal medicine whitening cream, it includes extracts of Chinese herbal medicine, surfactant, propane diols, hard
Resin acid glyceride, vaseline, water.In the Chinese herbal medicine whitening cream weight of each raw material be respectively extracts of Chinese herbal medicine 10g~
15g, surfactant 20g~30g, propane diols 30g~50g, glyceryl stearate 20g~30g, vaseline 40g~60g, water
100g~150g.
Preferably, the weight of each raw material is respectively extracts of Chinese herbal medicine 12g, surfactant in the Chinese herbal medicine whitening cream
25g, propane diols 40g, glyceryl stearate 25g, vaseline 50g, water 120g.
Present invention also offers the preparation method of said herbal medicine whitening cream, it includes：
The first step, prepares the extracts of Chinese herbal medicine；
Second step, weighs vaseline, tristerin, surfactant and is placed in container by weight, is heated to melting,
Temperature is maintained at 90 DEG C, obtains oil phase；
3rd step, is scattered in propane diols by extracts of Chinese herbal medicine by weight, further adds water, and stirring to be allowed to disperse,
60~70 DEG C are then heated to, 30~60min of stirring and dissolving slightly stands to remove blibbing to transparent clarification shape；It is cooled to
30~40 DEG C, transparent fluid viscosity to be dissolved increases and starts in emulsion form, the oil phase for adding second step to obtain, and continuation stirring 30~
45min, paste finished product is obtained final product after standing 12~24h.
Specifically, the bulk drug of the extracts of Chinese herbal medicine include reticulate millettia, rhizoma atractylodis, Chinese gall, Selaginella tamariscina, sea-buckthorn, Tu
Son, sealwort, coix seed, Dicliptera chinensis, rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, road
Road leads to and adenophora tetraphylla, and the extracts of Chinese herbal medicine is only made up of above-mentioned raw materials medicine.
The weight of each bulk drug is respectively reticulate millettia 30g~40g, rhizoma atractylodis 10g~20g, five in the extracts of Chinese herbal medicine
Gall nut 15g~25g, Selaginella tamariscina 10g~20g, sea-buckthorn 10g~20g, Semen Cuscutae 20g~30g, sealwort 25g~35g, coix seed 10g
~20g, Dicliptera chinensis 10g~20g, rhodiola root 15g~25g, root of Dahurain angelica 45g~55g, chicken muscle ginseng 15g~25g, Asian puccoon 10g~20g,
Dioscoreae septemlobae,rhizoma 15g~25g, hairy euphorbia 10g~20g, agalloch eaglewood 10g~20g, cattail pollen 25g~35g, caulis bambusae in taenian 15g~25g, play both sides of the street 5g
~15g and adenophora tetraphylla 10g~20g.
Preferably, in the extracts of Chinese herbal medicine weight of each bulk drug be respectively reticulate millettia 33g~37g, rhizoma atractylodis 13g~
17g, Chinese gall 18g~22g, Selaginella tamariscina 13g~17g, sea-buckthorn 13g~17g, Semen Cuscutae 23g~27g, sealwort 28g~32g, Job's tears
Benevolence 13g~17g, Dicliptera chinensis 13g~17g, rhodiola root 18g~22g, root of Dahurain angelica 48g~52g, chicken muscle ginseng 18g~22g, Asian puccoon 13g
~17g, dioscoreae septemlobae,rhizoma 18g~22g, hairy euphorbia 13g~17g, agalloch eaglewood 13g~17g, cattail pollen 28g~32g, caulis bambusae in taenian 18g~22g, road
Road leads to 8g~12g and adenophora tetraphylla 13g~17g.
Most preferably, in the extracts of Chinese herbal medicine weight of each bulk drug be respectively reticulate millettia 35g, rhizoma atractylodis 15g, five times
Sub- 20g, Selaginella tamariscina 15g, sea-buckthorn 15g, Semen Cuscutae 25g, sealwort 30g, coix seed 15g, Dicliptera chinensis 15g, rhodiola root 20g, the root of Dahurain angelica
50g, chicken muscle ginseng 20g, Asian puccoon 15g, dioscoreae septemlobae,rhizoma 20g, hairy euphorbia 15g, agalloch eaglewood 15g, cattail pollen 30g, caulis bambusae in taenian 20g, play both sides of the street 10g and
Adenophora tetraphylla 15g.
The preparation method of the extracts of Chinese herbal medicine is specially：
The first step, each bulk drug is crushed respectively, is put into container and is mixed, and obtains mixture, adds 8~10 times to mix
The distilled water of the quality of compound, after 5~6h of immersion, 3~4h is boiled in heating, filters, and obtains first time filtered fluid；
Second step, adds 6~8 times of distilled water of the quality of mixture again in the filter residue that filtering is obtained, and heating boils 2
~3h, second filtering, obtains second filtered fluid；
3rd step, 4~6 times of distilled water of the quality of mixture are added in the filter residue that second filtering is obtained, and are heated
1~2h is boiled, third time is filtered, and obtains third time filtered fluid；
4th step, merges above-mentioned three filtered fluids, filters again, obtains filtrate, is condensed into the extract solution of 0.5g/ml.
The surfactant is novel gemini surfactants, it is characterized by, its hydrophobic base section is by asphalt mixtures modified by epoxy resin fat chain
Section is formed, and polymer has below general formula：
X, y, z are the integer from 1 to 5, and R is methyl, ethyl or benzyl.
Wherein, E represents epoxy resin, and its structure is represented by：
M is the integer from 1 to 5, and epoxy resin is E51.
Second technical problem that the present invention is solved is the preparation method of above-mentioned novel gemini surfactants, and its feature exists
In comprising the following steps：
The first step, the preparation of many amine polymers of epoxy resin, epoxy resin is added in reactor, adds organic solvent molten
Solution, obtains epoxy resin solution, and polyamines is dissolved in certain organic solvent, and many amine aqueous solutions for obtaining are added drop-wise into epoxy again
In resin, completion of dropping, stirring is depressurized after 1-2 hours and boils off solvent, obtains many amine polymers of epoxy resin；
Second step, the preparation of phosphate Gemini surface active agent, toward many amine polymers of epoxy resin add phosphorous acid and
Hydrochloric acid, is warming up to 70~80 DEG C, and 36% formalin is added dropwise toward system, and stirring is cooled down after 1~2 hour, has insoluble matter to separate out,
Clear liquid is poured out, with vigorous stirring, 10% sodium hydroxide solution is added dropwise toward system the inside, system is clarified and obtains phosphate double gradually
Sub- surfactant solution.
The organic solvent of dissolved epoxy is C in the first step1~C3One or more in alcohol, preferably, institute
State organic solvent refer to methyl alcohol or ethanol or both with the mixture of arbitrary proportion；The ratio of epoxy resin and organic solvent
It is that weight ratio is 2.0:1~4.0:1.
Polyamines can be ethylenediamine, diethylenetriamine, triethylene tetramine, preferably TEPA, second in the first step
Diamines, the organic solvent for dissolving polyamines is C1~C3One or more in alcohol, preferably, the organic solvent refers to methyl alcohol
Or ethanol or both with the mixture of arbitrary proportion, polyamines is that weight ratio is 1.0 with the ratio of organic solvent:1~2.0:
1。
The ratio of the described first epoxy resin and polyamines step by step is the molal quantity of epoxy and rubbing for polyamines in epoxy resin
The ratio between your number is 1:1.2~1.8, preferably 1:1.5；Reaction temperature is 30~80 DEG C, preferably 60-80 DEG C.
In the second step, many amine polymers of epoxy resin first pass through Mannich reactions, then with NaOH and obtaining
Phosphate Gemini surface active agent, first can react with halogenated acetic acids, then with NaOH and obtaining carboxylate gemini surface
Activating agent, can obtain Bis-quaternary Ammonium Surfactants with alkylating reagent reaction.
Phosphorous acid in the second step is with the amount of many amine polymers of epoxy resin：Phosphorous acid and nitrogen-atoms in polyamines
Mol ratio is 1.1~1.5:1, preferably 1.2:1；Formaldehyde is 1.2~1.8 with the mol ratio of phosphorous acid:1, preferably 1.5:1；Hydrochloric acid
It is 1.0~3.0 with the mol ratio of phosphorous acid:1, preferably 2.0:1；NaOH is 1.0 with the mol ratio of nitrogen-atoms in polyamines:1.
Reaction temperature in the second step is 60~100 DEG C, preferably 70~80 DEG C.
The surfactant is applied in whitening cream of the invention, with multiple hydrophobic groups and multiple hydrophilic groups.It is special
Different structure causes that herbal component has fully played effect.
Describe embodiments of the present invention in detail using embodiment below, whereby to the present invention how application technology means
To solve technical problem, and reach the implementation process of technique effect and can fully understand and implement according to this.
The extracts of Chinese herbal medicine 1 of embodiment 1
By reticulate millettia 35g, rhizoma atractylodis 15g, Chinese gall 20g, Selaginella tamariscina 15g, sea-buckthorn 15g, Semen Cuscutae 25g, sealwort 30g, Job's tears
Benevolence 15g, Dicliptera chinensis 15g, rhodiola root 20g, root of Dahurain angelica 50g, chicken muscle ginseng 20g, Asian puccoon 15g, dioscoreae septemlobae,rhizoma 20g, hairy euphorbia 15g, agalloch eaglewood
15g, cattail pollen 30g, caulis bambusae in taenian 20g, the 10g and adenophora tetraphylla 15g that plays both sides of the street are crushed respectively, are put into container and are mixed, and are mixed
Thing, adds the distilled water of 3.7kg, and after immersion 6h, 4h is boiled in heating, is filtered, and obtains first time filtered fluid, in the filter residue that filtering is obtained
In add the distilled water of 3kg again, 3h is boiled in heating, filters for second, obtains second filtered fluid, is obtained in second filtering
Filter residue in add the distilled water of 2kg, 2h is boiled in heating, and third time is filtered, and obtains third time filtered fluid, is merged above-mentioned three times
Filtered fluid, filters again, obtains filtrate, is condensed into the extract solution 1 of 0.5g/ml.
The extracts of Chinese herbal medicine 2 of embodiment 2
By reticulate millettia 33g, rhizoma atractylodis 13g, Chinese gall 18g, Selaginella tamariscina 13g, sea-buckthorn 13g, Semen Cuscutae 23g, sealwort 28g, Job's tears
Benevolence 13g, Dicliptera chinensis 13g, rhodiola root 18g, root of Dahurain angelica 48g, chicken muscle ginseng 18g, Asian puccoon 13g, dioscoreae septemlobae,rhizoma 18g, hairy euphorbia 13g, agalloch eaglewood
13g, cattail pollen 28g, caulis bambusae in taenian 18g, the 8g and adenophora tetraphylla 13g that plays both sides of the street are crushed respectively, are put into container and are mixed, and are mixed
Thing, adds the distilled water of 3.7kg, and after immersion 6h, 4h is boiled in heating, is filtered, and obtains first time filtered fluid, in the filter residue that filtering is obtained
In add the distilled water of 3kg again, 3h is boiled in heating, filters for second, obtains second filtered fluid, is obtained in second filtering
Filter residue in add the distilled water of 2kg, 2h is boiled in heating, and third time is filtered, and obtains third time filtered fluid, is merged above-mentioned three times
Filtered fluid, filters again, obtains filtrate, is condensed into the extract solution 2 of 0.5g/ml.
The extracts of Chinese herbal medicine 3 of embodiment 3
By reticulate millettia 37g, rhizoma atractylodis 17g, Chinese gall 22g, Selaginella tamariscina 17g, sea-buckthorn 17g, Semen Cuscutae 27g, sealwort 32g, Job's tears
Benevolence 17g, Dicliptera chinensis 17g, rhodiola root 22g, root of Dahurain angelica 52g, chicken muscle ginseng 22g, Asian puccoon 17g, dioscoreae septemlobae,rhizoma 22g, hairy euphorbia 17g, agalloch eaglewood
17g, cattail pollen 32g, caulis bambusae in taenian 22g, the 12g and adenophora tetraphylla 17g that plays both sides of the street are crushed respectively, are put into container and are mixed, and are mixed
Thing, adds the distilled water of 3.7kg, and after immersion 6h, 4h is boiled in heating, is filtered, and obtains first time filtered fluid, in the filter residue that filtering is obtained
In add the distilled water of 3kg again, 3h is boiled in heating, filters for second, obtains second filtered fluid, is obtained in second filtering
Filter residue in add the distilled water of 2kg, 2h is boiled in heating, and third time is filtered, and obtains third time filtered fluid, is merged above-mentioned three times
Filtered fluid, filters again, obtains filtrate, is condensed into the extract solution 3 of 0.5g/ml.
The surfactant of embodiment 4
By in epoxy resin (E51) 18.8g addition reactors, the stirring of 8mL methyl alcohol is added, ethylenediamine 8.5mL is dissolved in
In 6mL methyl alcohol, the methanol solution of ethylenediamine is added drop-wise in epoxy resin at room temperature, it is small that completion of dropping is warmed up to 80 DEG C of stirrings 2
Shi Hou, is cooled to room temperature, and decompression boils off solvent, obtains many amine polymers of epoxy resin.50% phosphorous acid solution 41.8g is added
System, adds concentrated hydrochloric acid 40mL.80 DEG C are warming up to, 36% formalin 28.7mL is added dropwise.Completion of dropping in 30 minutes.Drip
Continue to stir 2 hours after finishing, cooling has insoluble matter to occur.Supernatant liquor is poured out, 10.2g NaOH is dissolved in 91.8mL water
In, then be added drop-wise to stirring in reaction system and obtain surfactant in 2 hours.
The infrared spectrum of the surfactant is shown in Fig. 1.
The whitening cream of embodiment 5
Vaseline 50g, tristerin 25g, the surfactant 25g of the preparation of embodiment 4 are weighed by weight is placed in appearance
In device, melting is heated to, temperature is maintained at 90 DEG C, obtains oil phase, the extracts of Chinese herbal medicine 12g for by weight preparing embodiment 1
It is scattered in propane diols 40g, further adds water 120g, and stirring to be allowed to disperse, is then heated to 60 DEG C, stirring and dissolving
60min slightly stands to remove blibbing to transparent clarification shape；30 DEG C are cooled to, transparent fluid viscosity increase to be dissolved starts
In emulsion form, previously obtained oil phase is added, continue to stir 45min, paste finished product is obtained final product after standing 24h.
The Skin Irritation Test of embodiment 6
Toxicology test
Acute toxicity test
Animal：Kunming mouse 50, body weight 20-22g, male and female half and half.
LD50 is calculated：Using improvement karber's method, mouse is randomly divided into 5 groups, every group 10, male and female half and half, by embodiment 5
The whitening cream of gained adds distillation water dissolves, is made into the whitening cream aqueous solution that concentration is 2g (crude drug)/L, and mouse is administered, and gives agent
Amount is calculated by crude drug amount, and every group is followed successively by 18g crude drugs/kg mouse, 14.4g crude drugs/kg mouse, 11.5g crude drugs/kg mouse,
9.2g crude drugs/kg mouse, 7.4g crude drugs/kg mouse after animal fasting (can't help water) 18 hours, are administered at twice in one day
(interval half an hour), each 0.5ml observes animal dead situation；
Maximum tolerated dose determines (MTD values)：
Take mouse 20, each 10 of male and female.The whitening cream of the gained of embodiment 5 is added into distillation water dissolves, concentration 2g is made into (raw
Medicine)/L the whitening cream aqueous solution, mouse is administered, by the maximal tolerance dose of animal, be defined by injecting to feed device and can twitch.Dynamic
After thing fasting (can't help water) 18 hours, it is administered at twice in one day (interval half an hour), each 0.5ml (contains crude drug per ml
0.36g), total dose is 18g crude drugs/kg mouse d, Continuous Observation 7 days after administration；
Said determination result is as follows：
In LD50In calculating when mouse is given with maximum acceptable concentration and maximum allowable capacity (18g crude drugs/Kg mouse
D), dead mouse is had no, that is, does not measure LD50, only seek maximum tolerated dose, in 7 day observation period, animal its appetite, work
Dynamic, hair color, state of mind etc. are all normal, and development is normal, there are no death.Show that acute toxicity is minimum, MTD ＞ 18g crude drugs/Kg
Mouse d.
Aggregate toxicity is tested
The whitening cream of the gained of embodiment 5 is added into distillation water dissolves, mouse is given birth to by 7.69 crude drug g/kg mouse, 19.18g
Medicine/kg mouse and 43.21g crude drugs/kg mouse continuous use 15 weeks (1.0ml/100g body weight, daily 2 times) and after being discontinued 3 weeks,
Result shows：Whitening cream of the invention to the hair of rat, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function,
The indexs such as blood sugar, blood fat have no significant effect, and internal organs naked eyes do not find that difference change and histological indications show, medication
15 weeks and be discontinued 3 weeks after, each internal organs of rat without substantially change.Whitening cream of the present invention is illustrated even as internal dosage form, its
To small toxicity after rat long-term prescription, also without abnormal reaction after drug withdrawal, using safety.
Intact skin irritation test
With healthy adult white, man exempts from 4,2.8~3.0kg of body weight, male and female half and half.
By its backbone both sides skin unhairing 3cm × 3cm, the whitening cream of the gained of Example 5 is in bis- layers of 2.5cm × 2.5cm
On gauze, be applied on a plucked skin in rabbit back side, covered with one layer of glassine paper, then with nonirritant medical proof fabric and
Bandage is fixed, and opposite side is compared with distilled water.After every experimental animal application 4h, tested material is removed, cleaned with warm water
The skin of application site, observes respectively at 1,24,48h and records the dermoreaction of application site, according to《Disinfection technology standard》
The standards of grading of regulation and classification are scored.Skin irritation test shows that the whitening cream that the present invention is provided is to family's rabbit skin
IR integration is 0, and skin belongs to non-stimulated without erythema.
The zoopery of embodiment 7
Material：Murine B 16 Melanoma Cells strain, DMEM culture mediums are purchased from Shanghai Medical Univ.Trypsase, L-
DOPA, Methyl thiazoly tetrazolium assay (MTT) are purchased from Sigma companies, CO2Incubator, Japanese SANYO companies, melanin detector, moral
CK companies of state, ELIASA, BIO-RAD companies of the U.S., spectrophotometer, Japanese HITACHI companies.
Experiment article：Whitening cream prepared by embodiment 5.
Mouse B16 melanocyte cultures：Under aseptic condition, by 1 × 105The mouse B16 melanocytes inoculation of individual/mL
In the blake bottle of the DMEM culture mediums containing 10% (volume fraction) calf serum, in 37 DEG C, 5%CO2Cultivated in incubator, often
3 days with 0.25% pancreatin had digestive transfer culture once.
The measure of cell proliferation rate
Cell growth to logarithmic phase is treated, is digested with 0.25% pancreatin, be adjusted to cell 2 × 104Individual/mL, is inoculated in 96 holes
In plate, per the μ L of hole 100.It is placed in after cultivating 24h in incubator, abandons supernatant, adds article to be measured.Each concentration sets 8 holes, right
Medicine is not added with according to group, instead of same amount maintaining liquid.It is incubated 72h.After medicine effect 72h, 5g/L MTT solution 10 μ L, 4h are added per hole
After abandon supernatant, DMSO100 μ L, vibration 10min or so are added per hole, each hole absorbance is detected on ELIASA, wavelength is
490nm。
Cell proliferation rate=medicine group mean absorbance values/control group mean absorbance values × 100%.
Intracellular melanin assay
By B16 melanocytes with 1 × 105The density of individual/mL is inoculated in 6 orifice plates.Per hole 3mL, after being incubated 24h, abandon
Clear liquid, adds article to be measured, after medicine effect 3d, abandons supernatant, and PBS washings add 0.5mL trypsin digestion cells per hole
3min, plus 2mL maintaining liquids terminate digestion, and every group of cell is counted respectively.Supernatant is abandoned in cell suspension centrifugation, and 1mol/L is added in precipitation
NaOH solution, 80 DEG C of heating 30min.Control group is not added with medicine, instead of same amount maintaining liquid.Spectrophotometer detects the suction of 475nm
Luminosity.
B16 cell inhibiting rate=[1- (medicine hole absorbance medicine hole cell number)/(control wells absorbance/right
According to hole cell number)] × 100%
Statistical procedures
Using SPSS13.0 statistical softwares, enumeration data uses chi-square criterion, measurement data withRepresent, checked using t,
It is that difference is statistically significant with P ＜ 0.05.
As a result
The melanocyte appreciation rate of the whitening cream that the present invention is provided, the results are shown in Table 1.
The melanocyte appreciation rate (%, with blank control group ratio) of the whitening cream that table 1 is provided using the present invention
| 4mg/ml | 2mg/ml | 1mg/ml | |
| Whitening cream | 37.6±3.1 | 53.9±6.2 | 75.1±9.3 |
As it can be seen from table 1 the concentration of the whitening cream for using is bigger, the growth rate for suppressing melanocyte is higher, to thin
The propagation of born of the same parents has significant inhibitory action.
Influence of the whitening cream that the present invention is provided to B16 cell, the results are shown in Table 2.
Influence of the whitening cream of table 2 to B16 cell
| Inhibiting rate % | |
| Whitening cream 4mg/ml | 78.91% |
| Whitening cream 2mg/ml | 46.29% |
| Blank control group | 0 |
From table 2 it can be seen that the concentration of whitening cream is higher, the suppression to B16 cell is more obvious, P<0.01.
All above-mentioned this intellectual properties of primarily implementation, the not this new product of implementation of setting limitation other forms
And/or new method.Those skilled in the art will be using this important information, the above modification, to realize similar execution feelings
Condition.But, all modifications or transformation are based on the right that new product of the present invention belongs to reservation.
The above, is only presently preferred embodiments of the present invention, is not the limitation for making other forms to the present invention, is appointed
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But it is every without departing from technical solution of the present invention content, according to technical spirit of the invention to above example institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.
Claims (9)
1. a kind of Chinese herbal medicine whitening cream, it is characterised in that:Lived including the extracts of Chinese herbal medicine for suppressing melanin generation, surface
Property agent, propane diols, glyceryl stearate, vaseline and water；The surfactant is Gemini surface active agent, its hydrophobic base portion
Divide and formed by epoxy resin segment, described surfactant has below general formula：
,
X, y, z are the integer from 1 to 5, and R is methyl, ethyl or benzyl, and E represents epoxy resin, and its representation is：
M is the integer from 1 to 5；
The mass ratio of extracts of Chinese herbal medicine, surfactant, propane diols, glyceryl stearate, vaseline and water is 10~15：20
~30：30~50：20~30：40~60：100~150, the bulk drug of the extracts of Chinese herbal medicine includes reticulate millettia, rhizoma atractylodis, five
Gall nut, Selaginella tamariscina, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis, rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, fly upward
Grass, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, play both sides of the street and adenophora tetraphylla, the reticulate millettia, rhizoma atractylodis, Chinese gall, Selaginella tamariscina, sea-buckthorn, Semen Cuscutae, Huang
Essence, coix seed, Dicliptera chinensis, rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood, cattail pollen, caulis bambusae in taenian, play both sides of the street
It is 30~40 with the weight ratio of adenophora tetraphylla：10~20：15~25：10~20：10~20：20~30：25~35：10~20：10
~20：15~25：45~55：15~25：10~20：15~25：10~20：10~20：25~35：15~25：5~15：10
~20.
2. a kind of Chinese herbal medicine whitening cream as claimed in claim 1, it is characterised in that：The reticulate millettia, rhizoma atractylodis, Chinese gall, volume
Cypress, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis, rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood,
Cattail pollen, caulis bambusae in taenian, to play both sides of the street with the weight ratio of adenophora tetraphylla be 33~37：13~17：18~22：13~17：13~17：23~27：
28~32：13~17：13~17：18~22：48~52：18~22：13~17：18~22：13~17：13~17：28~32：
18~22：8~12：13~17.
3. a kind of Chinese herbal medicine whitening cream as claimed in claim 2, it is characterised in that：The reticulate millettia, rhizoma atractylodis, Chinese gall, volume
Cypress, sea-buckthorn, Semen Cuscutae, sealwort, coix seed, Dicliptera chinensis, rhodiola root, the root of Dahurain angelica, chicken muscle ginseng, Asian puccoon, dioscoreae septemlobae,rhizoma, hairy euphorbia, agalloch eaglewood,
Cattail pollen, caulis bambusae in taenian, to play both sides of the street with the weight ratio of adenophora tetraphylla be 35：15：20：15：15：25：30：15：15：20：50：20：15：20：
15：15：30：20：10：15.
4. a kind of Chinese herbal medicine whitening cream as claimed in claim 1, it is characterised in that：Described epoxy resin is E51.
5. a kind of Chinese herbal medicine whitening cream as claimed in claim 1, it is characterised in that:Described
The preparation method of Gemini surface active agent is comprised the following steps：
The first step, one the step of prepare epoxy resin many amine polymers, epoxy resin is added in a reactor, adds the
One organic solvent is dissolved, and obtains epoxy resin solution, and polyamines is dissolved in the second organic solvent, and many amine aqueous solutions that will be obtained are again
It is added drop-wise in epoxy resin solution, completion of dropping, stirring is depressurized after 1-2 hours and boils off solvent, obtains the polymerization of epoxy resin polyamines
Thing；
Second step, one the step of prepare phosphate Gemini surface active agent, phosphorous is added toward many amine polymers of epoxy resin
Acid and hydrochloric acid, are warming up to 70~80 DEG C, and formalin is added dropwise toward system, and stirring is cooled down after 1~2 hour, has insoluble matter to separate out,
Clear liquid is poured out, with vigorous stirring, sodium hydroxide solution is added dropwise toward system the inside, system is clarified and obtains phosphate double sublist gradually
Face activator solution.
6. a kind of Chinese herbal medicine whitening cream as claimed in claim 5, it is characterised in that:First organic solvent is C1~C3 alcohol
In the combination of one or more, described epoxy resin and the weight ratio of the first organic solvent are 2.0:1~4.0:1.
7. a kind of Chinese herbal medicine whitening cream as claimed in claim 5, it is characterised in that:Described polyamines is ethylenediamine, described
Second organic solvent is one or more in C1~C3 alcohol, and the weight ratio of polyamines and the second organic solvent is 1.0:1~2.0:
1。
8. a kind of Chinese herbal medicine whitening cream as claimed in claim 5, it is characterised in that:The molal quantity of epoxy in the epoxy resin
It is 1 with the ratio between the molal quantity of polyamines:1.2~1.8.
9. a kind of Chinese herbal medicine whitening cream as claimed in claim 5, it is characterised in that:Described phosphorous acid and nitrogen-atoms in polyamines
Mol ratio be 1.1~1.5:1, formaldehyde is 1.2~1.8 with the mol ratio of phosphorous acid:1, hydrochloric acid is with the mol ratio of phosphorous acid
1.0~3.0:1, NaOH is 1.0 with the mol ratio of nitrogen-atoms in polyamines:1.
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|---|---|---|---|---|
| US5944650A (en) * | 1997-10-29 | 1999-08-31 | Xerox Corporation | Surfactants |
| CN101816759A (en) * | 2009-02-26 | 2010-09-01 | 罗蔚 | Acne-removing refine whitening cream and preparation method thereof |
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