CN104706562A - Whitening cream prepared from Chinese herbal medicines, and preparation method of whitening cream - Google Patents

Abstract

The invention provides a whitening cream prepared from Chinese herbal medicines. The whitening cream comprises a Chinese herbal medicine extracting solution for restraining melanin, a surfactant, propylene glycol, glyceryl stearate, petrolatum and water in the mass ratio of (10-15):(20-30):(30-50):(20-30):(40-60):(100-150), wherein the Chinese herbal medicine extracting solution comprises the raw medicines of suberect spatholobus stems, atractylodes rhizome, Chinese gall, spikemoss, hippophae rhamnoide, semen cuscutae, rhizoma polygonati, coix seed, dicliptera, rhodiola rosea, angelica dahurica, Damnacanthus macrophyllus Sieb.ex Mig.var giganteus(Makion)koidz, lithospermum, dioscorea septemloba, euphorbia hirta, eaglewood, cattail pollen, caulis bambusae in taeniis, beautiful sweetgum fruit and fourleaf ladybell roots. The whitening cream provided by the invention can inhibit the generation of melanin, has the effect of gently nursing skin, and does not generate strong stimulate, so that the skin is not damaged.

Description

A kind of Chinese herbal medicine whitening cream and preparation method thereof

Technical field

The invention belongs to chemical field, particularly relate to a kind of cosmetics, specifically a kind of Chinese herbal medicine whitening cream and preparation method thereof.

Background technology

The physiological whitening of reducing to melanin by the covering whitening of physical property from 20 century 70s changes, and the change of essence occurs the idea of people to skin-whitening.Whitening function and melanin are inseparable, first melanin generate at stratum basale, then the dendron along melanocyte is passed to keratinocyte, epidermis is piled up in gradually with Keratinocytic metabolism, cause melanin deposition, therefore can be generated by check melanin, check melanin transmission, smash melanin and realize whitening with cleaning cortex.Utilizing the activity of biological preparation, herbal development energy restraint of tyrosinase, prevent melanin from being formed, the physiological skin-lightening cosmetic of safe and effective removal skin splash, is the key areas of 21 century beauty treatment science.

Traditional cosmetics are often containing chemical compositions such as acid, alkali, salt, surfactants.These chemical substances cause irritant skin pathological changes through often after acting on the mucosa etc. of skin, organ, become zest contact dermatitis, cause skin lesion, also make local skin occur inflammation rapidly.

Chinese herbal medicine is the important treasure-house that Ancient Times in China doctor leaves descendant for, China is the cradle of Traditional Chinese Medicine Chinese medicine, to the application of Chinese herbal medicine in health and beauty, oneself has the history of more than 3,000 year, at successive dynasties medical science classical works, as the Classic of Mountains and Rivers of the Warring States Period, the Shennong's Herbal of Qin Han the period of Three Kingdoms, the supplement to Thousand Golden Prescriptions that the Tang Dynasty Sun Si satisfies, Song dynasty Chen Zhao meets, the Holy Benevolent Prescriptions that Wang Huaiyin etc. write, the Compendium of Material Medica of famous pharmacy man of Ming Dynasty Li Shizhen (1518-1593 A.D.), " prescriptions worth thousand gold spread out justice " of Qing Dynasty Zhang Lu, " herbal guiding principle day picks up any lost article from the road " of ZHAO Xue-Min etc. are all provided with the special section of beauty treatment, deep elaboration is had from theory into action, and compiled example and the formula of a large amount of Chinese medicine looks improving and the skin nourishing.In ancient medical book, Chinese medicine beauty treatment content vastness is extensive, is that ancestors leave over to the treasure of modern.

Chinese herbal medicine by lowering the links such as tyrosinase cdna expression, pheron synthesis, oxidation activity, can reach the effect reducing melanin genesis.A lot of research work is many now launches round this center target spot of tryrosinase, also has scholar to notice other link of metabolism of pigment.

Summary of the invention

For above-mentioned technical problem of the prior art, the invention provides a kind of Chinese herbal medicine whitening cream and preparation method thereof, described this Chinese herbal medicine whitening cream and preparation method thereof solves cosmetics of the prior art and often causes irritant skin pathological changes, become zest contact dermatitis, cause skin lesion, also make local skin occur rapidly the technical problem of inflammation.

A kind of Chinese herbal medicine whitening cream of the present invention, comprises the extracts of Chinese herbal medicine generated for check melanin, surfactant, propylene glycol, glyceryl stearate, vaseline and water, extracts of Chinese herbal medicine, surfactant, propylene glycol, glyceryl stearate, the mass ratio of vaseline and water is 10 ~ 15:20 ~ 30:30 ~ 50:20 ~ 30:40 ~ 60:100 ~ 150, and the crude drug of described extracts of Chinese herbal medicine comprises Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle is joined, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, Fructus Liquidambaris and Radix Adenophorae, described Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle is joined, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, the weight ratio of Fructus Liquidambaris and Radix Adenophorae is 30 ~ 40:10 ~ 20:15 ~ 25:10 ~ 20:10 ~ 20:20 ~ 30:25 ~ 35:10 ~ 20:10 ~ 20:15 ~ 25:45 ~ 55:15 ~ 25:10 ~ 20, : 15 ~ 25:10 ~ 20:10 ~ 20:25 ~ 35:15 ~ 25:5 ~ 15:10 ~ 20.

Further, the weight ratio of described Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle ginseng, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, Fructus Liquidambaris and Radix Adenophorae is 33 ~ 37:13 ~ 17:18 ~ 22:13 ~ 17:13 ~ 17:23 ~ 27:28 ~ 32:13 ~ 17:13 ~ 17:18 ~ 22:48 ~ 52:18 ~ 22:13 ~ 17:18 ~ 22:13 ~ 17:13 ~ 17:28 ~ 32:18 ~ 22:8 ~ 12:13 ~ 17.

Further, the weight ratio of described Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle ginseng, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, Fructus Liquidambaris and Radix Adenophorae is 35:15:20:15:15:25:30:15:15:20:50:20:15:20:15:15:30:20:10: 15.

Further, described surfactant is Gemini surface active agent, and its hydrophobic group part is formed by epoxy resin segment, and polymer has following general formula:

X, y, z are the integer from 1 to 5, and R is methyl, ethyl or benzyl, and E represents epoxy resin, and its structure can be shown

Show for:

m is the integer from 1 to 5.

Further, described epoxy resin is E51.

Further, described first organic solvent is the combination of one or more in C1 ~ C3 alcohol, and described epoxy resin and the weight ratio of organic solvent are 2.0:1 ~ 4.0:1.

Further, described polyamines is ethylenediamine, diethylenetriamine, triethylene tetramine or TEPA, and the second described organic solvent is one or more in C1 ~ C3 alcohol, and the weight ratio of polyamines and the second organic solvent is 1.0:1 ~ 2.0:1.

Further, in described epoxy resin, the molal quantity of epoxy is 1:1.2 ~ 1.8 with the ratio of the molal quantity of polyamines.

Further, in described phosphorous acid and polyamines, the mol ratio of nitrogen-atoms is 1.1 ~ 1.5:1, the mol ratio of formaldehyde and phosphorous acid is 1.2 ~ 1.8:1, and the mol ratio of hydrochloric acid and phosphorous acid is 1.0 ~ 3.0:1, and in sodium hydroxide and polyamines, the mol ratio of nitrogen-atoms is 1.0:1.

Further, the preparation method of described Gemini surface active agent comprises the following steps:

The first step, a step preparing epoxy resin polyamines polymer, epoxy resin is added in a reactor, add the first organic solvent dissolution, obtain epoxy resin solution, polyamines is dissolved in the second organic solvent, the polyamines solution of acquisition is added drop-wise in epoxy resin again, dropwise, stir pressure reducing and steaming solvent after 1-2 hour, obtain epoxy resin polyamines polymer;

Second step, a step preparing phosphate Gemini surface active agent, in epoxy resin polyamines polymer, add phosphorous acid and hydrochloric acid, be warming up to 70 ~ 80 DEG C, in system, drip formalin, stir after 1 ~ 2 hour and cool, there is insoluble matter to separate out, pour out clear liquid, with vigorous stirring, inside system, drip sodium hydroxide solution, system is gradually clarified and is obtained phosphate double sub-surface activator solution.

Present invention also offers the preparation method of above-mentioned a kind of Chinese herbal medicine whitening cream, comprise the following steps:

The first step, prepares described extracts of Chinese herbal medicine;

Second step, takes each material according to weight ratio, and vaseline, tristerin, surfactant are placed in a container, and be heated to melting, temperature remains on 85-95 DEG C, obtains oil phase;

3rd step, is scattered in extracts of Chinese herbal medicine in propylene glycol, adds water, and stirring makes it dispersion, is then heated to 60 ~ 70 DEG C, and stirring and dissolving 30 ~ 60min, to transparent clarification shape, leaves standstill to remove blibbing; Be cooled to 30 ~ 40 DEG C, transparent liquid viscosity to be dissolved increases and starts, in emulsion form, to add the oil phase that second step obtains, and continues stirring 30 ~ 45min, namely obtains paste finished product after leaving standstill 12 ~ 24h.

Further, the preparation method of described extracts of Chinese herbal medicine comprises the following steps:

The first step, pulverizes respectively by crude drug, puts into a container and mixes, obtain mixture, add the distilled water of 8 ~ 10 times of mixture qualities, and after soaking 5 ~ 6h, heated and boiled 3 ~ 4h, filters, and obtains first time filtrate;

Second step, filtering the distilled water again adding the quality of 6 ~ 8 times of mixture in the filtering residue obtained, heated and boiled 2 ~ 3h, second time is filtered, and obtains second time filtrate;

3rd step, filters the distilled water adding the quality of 4 ~ 6 times of mixture in the filtering residue obtained again, heated and boiled 1 ~ 2h in second time, third time filters, and obtains third time filtrate;

4th step, merges above-mentioned three filtrate, again filters, obtain filtrate, concentrates and obtains extracts of Chinese herbal medicine.

Each crude drug pharmacology is as follows:

Caulis Spatholobi: latin name spatholobi caulis, bitter in the mouth, sweet, warm in nature, return liver, kidney channel, have blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, cure mainly the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and dampness, the effect of improving eyesight, be mainly used in the stomachache dysentery of retention of dampness in middle-JIAO, the abdominal distention pain of incoordination between the spleen and stomach, vomits indigestion and loss of appetite; The abdomen side of body distending pain, the vomiting with acid regurgitation of incoordination between the liver and stomach; And the card such as the anemofrigid-damp arthralgia of the outer strongly fragrant meridians of cold-damp.

Galla Chinensis: latin name Galla Chinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle skin ulcer Rhizoma Atractylodis furuncle.

Herba Selaginellae: latin name Selaginellae Herba is the dry herb of Spikemoss plant Herba Selaginellae or Selaginella pulvinata, acrid in the mouth, and property is put down, and returns liver, heart channel, there is effect of promoting blood circulation to restore menstrual flow, for amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, spit blood, metrorrhagia, has blood in stool, the cards such as proctoptosis.

Fructus Hippophae: sour in the mouth; Puckery; Warm in nature, there is relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; Effect of promoting blood circulation to remove blood stasis.Cure mainly cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal is scorching; Amenorrhea; The cards such as traumatic injury congestive edema.

Semen Cuscutae: sweet in the mouth, pungent, property is put down, and enters liver,kidney,spleen warp, there is the kidney invigorating and essence nourishing, effect of nourishing the liver to improve visual acuity, cure mainly the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus, to suffer from a deficiency of the kidney pain in the lumbar region, married woman's leukorrhagia, nausea is not solid, and the binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision, the loose stool stomachache of asthenia of both the spleen and kidney, the cards such as aqueous-grainy diarrhea.

Rhizoma Polygonati: latin name Polygonati Rhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.Have the function of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, for weakness of the spleen and stomach, suffer from diarrhoea in loose stool, or vaginal discharge diseases of women, insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache.

Herba Diclipterae Chinensis: be the herb of Acanthaceae Herba Diclipterae Chinensis platymiscium Herba Diclipterae Chinensis, sweet in the mouth, micro-hardship, cold in nature, GUIXIN, liver, lung meridian, have heat clearing away, removing heat from blood, dampness removing, effect of removing toxic substances, cure mainly cold, fever, calentura sends out speckle, has blood in stool, hematuria, metrorrhagia, cough due to lung-heat, laryngopharynx swelling and pain, liver-heat conjunctival congestion, infantile convulsion; dribbling urination, leukorrhagia, the cards such as Serpentis lyssodexis.

Chicken muscle is joined: for Rubiaceae Herba Damnacanthi platymiscium comes into leaves the root of beads tree, mildly bitter flavor, sweet, property is put down, and has invigorating QI and blood, anastaltic effect, cures mainly women's snowslide, discharging fresh blood stool, the cards such as weak blood deficiency.

Miliaria alba grass: acrid in the mouth, hardship, slightly warm in nature, has to deliver and drives away summer heat, dampness removing and in, effect that loose wind is antipruritic, cures mainly anemofrigid cold, and febrile disease of YIN type in summer is had a headache, wrist pain of feeling sick, dysentery, edema, hemorrhoidal bleeding, pudendal pruritus eczema, traumatic hemorrhage, the cards such as snake bite and insect sting.

Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel, have removing heat from blood and promoting blood circulation, effect of removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, the cards such as constipation with heat retention.

Rhizoma Dioscoreae Septemlobae: latin name Dioscoreae Spongiosae Rhizoma, property is put down, and bitter in the mouth, returns kidney, stomach warp, has dampness removing and goes turbid, the effect of the blood stasis dispelling that dispels the wind, for cards such as gonorrhea nebulousurine, leukorrhagia, damp and hot sore, waist knee joint arthralgia pain.

Ramulus et Folium Bauhiniae Faberi: latin name Euphorbiae Hirate Herba, mildly bitter flavor, micro-acid, cool in nature, there is heat-clearing and toxic substances removing, effect that dampness removing is antipruritic, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, skin pruritus are controlled in external.

Lignum Aquilariae Resinatum: acrid in the mouth, hardship, warm in nature, return spleen, stomach, kidney, lung meridian, there is sending down the abnormal ascending QI warming middle-JIAO, effect of warming the kidney improving inspiration by invigorating kidney-QI, cure mainly QI rising in reverse order and pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, the cards such as man's cold sperm.

Pollen Typhae: sweet in the mouth, property is put down, and enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.

Caulis Bambusae In Taenia: cold nature, sweet in the mouth, attaches to the lung and stomach meridians, and has removing heat-phlegm, the effect relieved restlessness and prevented vomiting, and holds the card such as expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.

Fructus Liquidambaris: latin name Liquidambaris Fructus, bitter in the mouth, property is put down, and returns liver, kidney channel, has dispelling, collateral-activating, effect that diuretic stimulates the menstrual flow, for arthralgia, numbness contracture, edema distension, the cards such as the few amenorrhea of breast.

Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enter lung, stomach warp, there is nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, be mainly used in lung-dryness syndrome due to deficiency of YIN, dry cough few expectorant, chronic cough expectorant blood, the cards such as the few tongue of deficiency of stomach-Yin, mouthfeel parched throat, constipation, red tongue, cellular immunization and non-specific immunity can be improved, suppress humoral immunization, there is the function of immunity moderation balance.

The present invention compares with prior art, and its technological progress is significant.The present invention utilizes theory of Chinese medical science, proposes a kind of Chinese herbal medicine whitening cream, realizes the generation of check melanin, meanwhile, adopts Chinese herbal medicine whitening, docile to skin nursing, can not produce strong stimulation, infringement skin itself.

Accompanying drawing explanation

Fig. 1: the infrared spectrum of surfactant.

Detailed description of the invention

The invention provides a kind of Chinese herbal medicine whitening cream, it comprises extracts of Chinese herbal medicine, surfactant, propylene glycol, glyceryl stearate, vaseline, water.In described Chinese herbal medicine whitening cream, the weight of each raw material is respectively extracts of Chinese herbal medicine 10g ~ 15g, surfactant 20g ~ 30g, propylene glycol 30g ~ 50g, glyceryl stearate 20g ~ 30g, vaseline 40g ~ 60g, water 100g ~ 150g.

Preferably, in described Chinese herbal medicine whitening cream, the weight of each raw material is respectively extracts of Chinese herbal medicine 12g, surfactant 25g, propylene glycol 40g, glyceryl stearate 25g, vaseline 50g, water 120g.

Present invention also offers the preparation method of said herbal medicine whitening cream, it comprises:

The first step, prepares described extracts of Chinese herbal medicine;

Second step, take vaseline by weight, tristerin, surfactant be placed in container, be heated to melting, temperature remains on 90 DEG C, obtains oil phase;

3rd step, is scattered in propylene glycol by extracts of Chinese herbal medicine by weight, adds water further, and stirring makes it dispersion, is then heated to 60 ~ 70 DEG C, and stirring and dissolving 30 ~ 60min, to transparent clarification shape, slightly leaves standstill to remove blibbing; Be cooled to 30 ~ 40 DEG C, transparent liquid viscosity to be dissolved increases and starts, in emulsion form, to add the oil phase that second step obtains, and continues stirring 30 ~ 45min, namely obtains paste finished product after leaving standstill 12 ~ 24h.

Concrete, the crude drug of described extracts of Chinese herbal medicine comprises Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle ginseng, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, Fructus Liquidambaris and Radix Adenophorae, and described extracts of Chinese herbal medicine is only made up of above-mentioned raw materials medicine.

In described extracts of Chinese herbal medicine, the weight of each crude drug is respectively Caulis Spatholobi 30g ~ 40g, Rhizoma Atractylodis 10g ~ 20g, Galla Chinensis 15g ~ 25g, Herba Selaginellae 10g ~ 20g, Fructus Hippophae 10g ~ 20g, Semen Cuscutae 20g ~ 30g, Rhizoma Polygonati 25g ~ 35g, Semen Coicis 10g ~ 20g, Herba Diclipterae Chinensis 10g ~ 20g, Radix Rhodiolae 15g ~ 25g, Radix Angelicae Dahuricae 45g ~ 55g, chicken muscle ginseng 15g ~ 25g, Radix Arnebiae (Radix Lithospermi) 10g ~ 20g, Rhizoma Dioscoreae Septemlobae 15g ~ 25g, Ramulus et Folium Bauhiniae Faberi 10g ~ 20g, Lignum Aquilariae Resinatum 10g ~ 20g, Pollen Typhae 25g ~ 35g, Caulis Bambusae In Taenia 15g ~ 25g, Fructus Liquidambaris 5g ~ 15g and Radix Adenophorae 10g ~ 20g.

Preferably, in described extracts of Chinese herbal medicine, the weight of each crude drug is respectively Caulis Spatholobi 33g ~ 37g, Rhizoma Atractylodis 13g ~ 17g, Galla Chinensis 18g ~ 22g, Herba Selaginellae 13g ~ 17g, Fructus Hippophae 13g ~ 17g, Semen Cuscutae 23g ~ 27g, Rhizoma Polygonati 28g ~ 32g, Semen Coicis 13g ~ 17g, Herba Diclipterae Chinensis 13g ~ 17g, Radix Rhodiolae 18g ~ 22g, Radix Angelicae Dahuricae 48g ~ 52g, chicken muscle ginseng 18g ~ 22g, Radix Arnebiae (Radix Lithospermi) 13g ~ 17g, Rhizoma Dioscoreae Septemlobae 18g ~ 22g, Ramulus et Folium Bauhiniae Faberi 13g ~ 17g, Lignum Aquilariae Resinatum 13g ~ 17g, Pollen Typhae 28g ~ 32g, Caulis Bambusae In Taenia 18g ~ 22g, Fructus Liquidambaris 8g ~ 12g and Radix Adenophorae 13g ~ 17g.

Most preferred, in described extracts of Chinese herbal medicine, the weight of each crude drug is respectively Caulis Spatholobi 35g, Rhizoma Atractylodis 15g, Galla Chinensis 20g, Herba Selaginellae 15g, Fructus Hippophae 15g, Semen Cuscutae 25g, Rhizoma Polygonati 30g, Semen Coicis 15g, Herba Diclipterae Chinensis 15g, Radix Rhodiolae 20g, Radix Angelicae Dahuricae 50g, chicken muscle ginseng 20g, Radix Arnebiae (Radix Lithospermi) 15g, Rhizoma Dioscoreae Septemlobae 20g, Ramulus et Folium Bauhiniae Faberi 15g, Lignum Aquilariae Resinatum 15g, Pollen Typhae 30g, Caulis Bambusae In Taenia 20g, Fructus Liquidambaris 10g and Radix Adenophorae 15g.

The preparation method of described extracts of Chinese herbal medicine is specially:

The first step, pulverizes respectively by each crude drug, puts into container and mixes, obtain mixture, adds the distilled water of the quality of 8 ~ 10 times of mixture, and after soaking 5 ~ 6h, heated and boiled 3 ~ 4h, filters, and obtains first time filtrate;

Second step, filtering the distilled water again adding the quality of 6 ~ 8 times of mixture in the filtering residue obtained, heated and boiled 2 ~ 3h, second time is filtered, and obtains second time filtrate;

3rd step, filters the distilled water adding the quality of 4 ~ 6 times of mixture in the filtering residue obtained again, heated and boiled 1 ~ 2h in second time, third time filters, and obtains third time filtrate;

4th step, merges above-mentioned three filtrate, again filters, obtain filtrate, be condensed into the extracting solution of 0.5g/ml.

Described surfactant is novel gemini surfactants, it is characterized by, and its hydrophobic group part is formed by epoxy resin segment, and polymer has following general formula:

X, y, z are the integer from 1 to 5, and R is methyl, ethyl or benzyl.

Wherein, E represents epoxy resin, and its structure can be expressed as:

M is the integer from 1 to 5, and epoxy resin is E51.

Second technical problem that the present invention solves is the preparation method of above-mentioned novel gemini surfactants, it is characterized in that comprising the following steps:

The first step, the preparation of epoxy resin polyamines polymer, epoxy resin is added in reactor, add organic solvent dissolution, obtain epoxy resin solution, polyamines is dissolved in certain organic solvent, the polyamines solution of acquisition is added drop-wise in epoxy resin again, dropwise, stir pressure reducing and steaming solvent after 1-2 hour, obtain epoxy resin polyamines polymer;

Second step, the preparation of phosphate Gemini surface active agent, in epoxy resin polyamines polymer, add phosphorous acid and hydrochloric acid, be warming up to 70 ~ 80 DEG C, in system, drip 36% formalin, stir after 1 ~ 2 hour and cool, there is insoluble matter to separate out, pour out clear liquid, with vigorous stirring, inside system, drip 10% sodium hydroxide solution, system is gradually clarified and is obtained phosphate double sub-surface activator solution.

In the described first step, the organic solvent of dissolved epoxy is C ₁~ C ₃one or more in alcohol, as preferably, described organic solvent refers to that methanol or ethanol or both are with the mixture of arbitrary proportion; The ratio of epoxy resin and organic solvent is weight ratio is 2.0:1 ~ 4.0:1.

In the described first step, polyamines can be ethylenediamine, diethylenetriamine, triethylene tetramine, TEPA, preferred ethylenediamine, and the organic solvent dissolving polyamines is C ₁~ C ₃one or more in alcohol, as preferably, described organic solvent refers to that methanol or ethanol or both are with the mixture of arbitrary proportion, and the ratio of polyamines and organic solvent is weight ratio is 1.0:1 ~ 2.0:1.

Described first step by step epoxy resin and the ratio of polyamines be that in epoxy resin, the molal quantity of epoxy is 1:1.2 ~ 1.8 with the ratio of the molal quantity of polyamines, preferred 1:1.5; Reaction temperature is 30 ~ 80 DEG C, preferred 60-80 DEG C.

In described second step, epoxy resin polyamines polymer is first reacted by Mannich, phosphate Gemini surface active agent is obtained again with sodium hydroxide neutralization, can first and halogenated acetic acids reaction, obtain carboxylate gemini surfactant with sodium hydroxide neutralization again, Bis-quaternary Ammonium Surfactants can be obtained by reacting with alkylating reagent.

The amount of the phosphorous acid in described second step and epoxy resin polyamines polymer is: in phosphorous acid and polyamines, the mol ratio of nitrogen-atoms is 1.1 ~ 1.5:1, preferred 1.2:1; The mol ratio of formaldehyde and phosphorous acid is 1.2 ~ 1.8:1, preferred 1.5:1; The mol ratio of hydrochloric acid and phosphorous acid is 1.0 ~ 3.0:1, preferred 2.0:1; In sodium hydroxide and polyamines, the mol ratio of nitrogen-atoms is 1.0:1.

Reaction temperature in described second step is 60 ~ 100 DEG C, preferably 70 ~ 80 DEG C.

This surfactant is applied in whitening cream of the present invention, there is multiple hydrophobic group and multiple hydrophilic group.Its special structure herbal component is fully played effect.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 extracts of Chinese herbal medicine 1

By Caulis Spatholobi 35g, Rhizoma Atractylodis 15g, Galla Chinensis 20g, Herba Selaginellae 15g, Fructus Hippophae 15g, Semen Cuscutae 25g, Rhizoma Polygonati 30g, Semen Coicis 15g, Herba Diclipterae Chinensis 15g, Radix Rhodiolae 20g, Radix Angelicae Dahuricae 50g, chicken muscle ginseng 20g, Radix Arnebiae (Radix Lithospermi) 15g, Rhizoma Dioscoreae Septemlobae 20g, Ramulus et Folium Bauhiniae Faberi 15g, Lignum Aquilariae Resinatum 15g, Pollen Typhae 30g, Caulis Bambusae In Taenia 20g, Fructus Liquidambaris 10g and Radix Adenophorae 15g pulverizes respectively, put into container to mix, obtain mixture, add the distilled water of 3.7kg, after soaking 6h, 4h is boiled in heating, filter, obtain first time filtrate, filtering the distilled water again adding 3kg in the filtering residue obtained, heated and boiled 3h, second time is filtered, obtain second time filtrate, the distilled water adding 2kg in the filtering residue obtained again is filtered in second time, heated and boiled 2h, third time filters, obtain third time filtrate, merge above-mentioned three filtrate, again filter, obtain filtrate, be condensed into the extracting solution 1 of 0.5g/ml.

Embodiment 2 extracts of Chinese herbal medicine 2

By Caulis Spatholobi 33g, Rhizoma Atractylodis 13g, Galla Chinensis 18g, Herba Selaginellae 13g, Fructus Hippophae 13g, Semen Cuscutae 23g, Rhizoma Polygonati 28g, Semen Coicis 13g, Herba Diclipterae Chinensis 13g, Radix Rhodiolae 18g, Radix Angelicae Dahuricae 48g, chicken muscle ginseng 18g, Radix Arnebiae (Radix Lithospermi) 13g, Rhizoma Dioscoreae Septemlobae 18g, Ramulus et Folium Bauhiniae Faberi 13g, Lignum Aquilariae Resinatum 13g, Pollen Typhae 28g, Caulis Bambusae In Taenia 18g, Fructus Liquidambaris 8g and Radix Adenophorae 13g pulverizes respectively, put into container to mix, obtain mixture, add the distilled water of 3.7kg, after soaking 6h, 4h is boiled in heating, filter, obtain first time filtrate, filtering the distilled water again adding 3kg in the filtering residue obtained, heated and boiled 3h, second time is filtered, obtain second time filtrate, the distilled water adding 2kg in the filtering residue obtained again is filtered in second time, heated and boiled 2h, third time filters, obtain third time filtrate, merge above-mentioned three filtrate, again filter, obtain filtrate, be condensed into the extracting solution 2 of 0.5g/ml.

Embodiment 3 extracts of Chinese herbal medicine 3

By Caulis Spatholobi 37g, Rhizoma Atractylodis 17g, Galla Chinensis 22g, Herba Selaginellae 17g, Fructus Hippophae 17g, Semen Cuscutae 27g, Rhizoma Polygonati 32g, Semen Coicis 17g, Herba Diclipterae Chinensis 17g, Radix Rhodiolae 22g, Radix Angelicae Dahuricae 52g, chicken muscle ginseng 22g, Radix Arnebiae (Radix Lithospermi) 17g, Rhizoma Dioscoreae Septemlobae 22g, Ramulus et Folium Bauhiniae Faberi 17g, Lignum Aquilariae Resinatum 17g, Pollen Typhae 32g, Caulis Bambusae In Taenia 22g, Fructus Liquidambaris 12g and Radix Adenophorae 17g pulverizes respectively, put into container to mix, obtain mixture, add the distilled water of 3.7kg, after soaking 6h, 4h is boiled in heating, filter, obtain first time filtrate, filtering the distilled water again adding 3kg in the filtering residue obtained, heated and boiled 3h, second time is filtered, obtain second time filtrate, the distilled water adding 2kg in the filtering residue obtained again is filtered in second time, heated and boiled 2h, third time filters, obtain third time filtrate, merge above-mentioned three filtrate, again filter, obtain filtrate, be condensed into the extracting solution 3 of 0.5g/ml.

Embodiment 4 surfactant

Epoxy resin (E51) 18.8g is added in reactor, add 8mL methanol to stir, ethylenediamine 8.5mL is dissolved in 6mL methanol, under room temperature, the methanol solution of ethylenediamine is added drop-wise in epoxy resin, dropwise and be warmed up to 80 DEG C of stirrings after 2 hours, cool to room temperature, pressure reducing and steaming solvent, obtains epoxy resin polyamines polymer.50% phosphorous acid solution 41.8g is added system, adds concentrated hydrochloric acid 40mL.Be warming up to 80 DEG C, drip 36% formalin 28.7mL.Dropwise in 30 minutes.Dropwise rear continuation stirring 2 hours, cooling, has insoluble matter to occur.Pour out the supernatant, 10.2g sodium hydroxide be dissolved in 91.8mL water, then be added drop-wise in reaction system stir within 2 hours, obtain surfactant.

The infrared spectrum of this surfactant is shown in Fig. 1.

Embodiment 5 whitening cream

Take by weight vaseline 50g, tristerin 25g, embodiment 4 prepare surfactant 25g be placed in container, be heated to melting, temperature remains on 90 DEG C, obtain oil phase, by weight extracts of Chinese herbal medicine 12g prepared by embodiment 1 is scattered in propylene glycol 40g, adds water 120g further, and stirring makes it dispersion, then be heated to 60 DEG C, stirring and dissolving 60min, to transparent clarification shape, slightly leaves standstill to remove blibbing; Be cooled to 30 DEG C, transparent liquid viscosity to be dissolved increases and starts, in emulsion form, to add the oil phase obtained above, continues to stir 45min, namely obtains paste finished product after leaving standstill 24h.

Embodiment 6 Skin Irritation Test

Toxicology test

Acute toxicity test

Animal: Kunming mouse 50, body weight 20-22g, male and female half and half.

LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, the whitening cream adding distil water of embodiment 5 gained is dissolved, be made into the whitening cream aqueous solution that concentration is 2g (crude drug)/L, to mice administration, raw medicine calculation is pressed to dosage by institute, often group is followed successively by 18g crude drug/kg mice, 14.4g crude drug/kg mice, 11.5g crude drug/kg mice, 9.2g crude drug/kg mice, 7.4g crude drug/kg mice, in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observe animal dead situation,

Maximum tolerated dose measures (MTD value):

Get mice 20, each 10 of male and female.The whitening cream adding distil water of embodiment 5 gained is dissolved, is made into the whitening cream aqueous solution of concentration 2g (crude drug)/L, to mice administration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in a day (interval half an hour), each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg mice d, Continuous Observation 7 days after administration;

Said determination result is as follows:

At LD ₅₀in calculating when giving mice with maximum acceptable concentration and maximum permission capacity (18g crude drug/Kg mice d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Show that acute toxicity is minimum, MTD > 18g crude drug/Kg mice d.

Aggregate toxicity is tested

The whitening cream adding distil water of embodiment 5 gained is dissolved, to mice by 7.69 crude drug g/kg mices, 19.18g crude drug/kg mice and 43.21g crude drug/kg mice continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: whitening cream of the present invention is to the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, the each internal organs of rat are all without obviously changing.Even if illustrate that whitening cream of the present invention is as dosage form for oral administration, it is little to toxicity after rat long-term prescription, does not also have difference reaction, application safety after drug withdrawal.

An intact skin irritation test

By healthy adult white, man exempts from 4, body weight 2.8 ~ 3.0kg, male and female half and half.

By its spinal column both sides skin unhairing 3cm × 3cm, the whitening cream of Example 5 gained is on 2.5cm × 2.5cm bis-layers of gauze, be applied on a plucked skin in rabbit back side, cover with one deck cellophane, fixed with nonirritant medical proof fabric and binder, opposite side distilled water compares again.Every experimental animal is applied ointment or plaster after 4h, removes tested material, with the skin of warm water cleaning application site, respectively at 1,24,48h observes and records the dermoreaction of application site, the standards of grading specified according to " disinfection technology standard " and classification are marked.Irritation test shows, whitening cream provided by the invention is 0 to rabbit skin wound repair integration, and skin, without erythema, belongs to non-stimulated.

Embodiment 7 zoopery

Material: Murine B 16 Melanoma Cells strain, DMEM culture medium are purchased from Shanghai Medical Univ.Trypsin, L-DOPA, Methyl thiazoly tetrazolium assay (MTT) are purchased from Sigma company, CO ₂incubator, Japanese SANYO company, melanin detector, German CK company, microplate reader, BIO-RAD company of the U.S., spectrophotometer, Japanese HITACHI company.

Experiment article: whitening cream prepared by embodiment 5.

Mice B16 melanocyte is cultivated: under aseptic condition, by 1 × 10 ⁵the mice B16 melanocyte of individual/mL is inoculated in the culture bottle containing the DMEM culture medium of 10% (volume fraction) calf serum, at 37 DEG C, 5%CO ₂cultivate in incubator, within every 3 days, go down to posterity once with 0.25% trypsinization.

The mensuration of cell proliferation rate

Treat that Growth of Cells arrives logarithmic (log) phase, use 0.25% trypsinization, adjust to cell 2 × 10 ⁴individual/mL, is inoculated in 96 orifice plates, every hole 100 μ L.Be placed in after incubator cultivates 24h, abandon supernatant, add article to be measured.Each concentration establishes 8 holes, and matched group does not add medicine, for it commensurability maintenance medium.Hatch 72h.After drug effect 72h, every hole adds 5g/L MTT solution 10 μ L, and abandon supernatant after 4h, every hole adds DMSO100 μ L, and vibration about 10min, microplate reader detects each hole absorbance, and wavelength is 490nm.

Cell proliferation rate=medicine group mean absorbance values/matched group mean absorbance values × 100%.

Intracellular melanin assay

By B16 melanocyte with 1 × 10 ⁵the density of individual/mL is inoculated in 6 orifice plates.Every hole 3mL, after hatching 24h, abandons supernatant, adds article to be measured, after drug effect 3d, abandons supernatant, and PBS washs, and every hole adds 0.5mL trypsin digestion cell 3min, adds 2mL maintenance medium and stops digestion, count respectively and often organize cell.Cell suspension is centrifugal abandons supernatant, adds 1mol/L NaOH solution in precipitation, 80 DEG C of heating 30min.Matched group does not add medicine, for it commensurability maintenance medium.Spectrophotometer detects the absorbance of 475nm.

B16 cell suppression ratio=[1-(medicine hole absorbance medicine porocyte number)/(control wells absorbance/control wells cell number)] × 100%

Statistical procedures

Adopt SPSS13.0 statistical software, enumeration data adopt chi-square criterion, measurement data with represent, adopt t inspection, with P < 0.05 for difference has statistical significance.

Result

The melanocyte appreciation rate of whitening cream provided by the invention, the results are shown in Table 1.

Table 1 adopts the melanocyte appreciation rate (%, with blank group ratio) of whitening cream provided by the invention

	4mg/ml	2mg/ml	1mg/ml
				Whitening cream	37.6±3.1	53.9±6.2	75.1±9.3

As can be seen from Table 1, the concentration of the whitening cream of employing is larger, and the rate of increase of check melanin cell is higher, has significant inhibitory action to the propagation of cell.

Whitening cream provided by the invention, on the impact of B16 cell, the results are shown in Table 2.

Table 2 whitening cream is on the impact of B16 cell

	Suppression ratio %
		Whitening cream 4mg/ml	78.91％
Whitening cream 2mg/ml	46.29％
		Blank group	0

As can be seen from Table 2, the concentration of whitening cream is higher, more obvious to the suppression of B16 cell, P<0.01.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (12)

1. a Chinese herbal medicine whitening cream, is characterized in that: comprise the extracts of Chinese herbal medicine generated for check melanin, surfactant, propylene glycol, glyceryl stearate, vaseline and water, extracts of Chinese herbal medicine, surfactant, propylene glycol, glyceryl stearate, the mass ratio of vaseline and water is 10 ~ 15:20 ~ 30:30 ~ 50:20 ~ 30:40 ~ 60:100 ~ 150, and the crude drug of described extracts of Chinese herbal medicine comprises Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle is joined, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, Fructus Liquidambaris and Radix Adenophorae, described Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle is joined, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, the weight ratio of Fructus Liquidambaris and Radix Adenophorae is 30 ~ 40:10 ~ 20:15 ~ 25:10 ~ 20:10 ~ 20:20 ~ 30:25 ~ 35:10 ~ 20:10 ~ 20:15 ~ 25:45 ~ 55:15 ~ 25:10 ~ 20, : 15 ~ 25:10 ~ 20:10 ~ 20:25 ~ 35:15 ~ 25:5 ~ 15:10 ~ 20.

2. a kind of Chinese herbal medicine whitening cream as claimed in claim 1, it is characterized in that: described Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle is joined, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, the weight ratio of Fructus Liquidambaris and Radix Adenophorae is 33 ~ 37:13 ~ 17:18 ~ 22:13 ~ 17:13 ~ 17:23 ~ 27:28 ~ 32:13 ~ 17:13 ~ 17:18 ~ 22:48 ~ 52:18 ~ 22:13 ~ 17:18 ~ 22:13 ~ 17:13 ~ 17:28 ~ 32:18 ~ 22:8 ~ 12:13 ~ 17.

3. a kind of Chinese herbal medicine whitening cream as claimed in claim 2, is characterized in that: the weight ratio of described Caulis Spatholobi, Rhizoma Atractylodis, Galla Chinensis, Herba Selaginellae, Fructus Hippophae, Semen Cuscutae, Rhizoma Polygonati, Semen Coicis, Herba Diclipterae Chinensis, Radix Rhodiolae, the Radix Angelicae Dahuricae, chicken muscle ginseng, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Septemlobae, Ramulus et Folium Bauhiniae Faberi, Lignum Aquilariae Resinatum, Pollen Typhae, Caulis Bambusae In Taenia, Fructus Liquidambaris and Radix Adenophorae is 35:15:20:15:15:25:30:15:15:20:50:20:15:20:15:15:30:20:10: 15.

4. a kind of Chinese herbal medicine whitening cream as claimed in claim 1, it is characterized in that: described surfactant is Gemini surface active agent, its hydrophobic group part is formed by epoxy resin segment, and polymer has following general formula:

X, y, z are the integer from 1 to 5, and R is methyl, ethyl or benzyl, and E represents epoxy resin, and its structure can be expressed as:

m is the integer from 1 to 5.

5. a kind of Chinese herbal medicine whitening cream as claimed in claim 4, is characterized in that: described epoxy resin is E51.

6. a kind of Chinese herbal medicine whitening cream as claimed in claim 4, is characterized in that: the preparation method of described Gemini surface active agent comprises the following steps:

The first step, a step preparing epoxy resin polyamines polymer, epoxy resin is added in a reactor, add the first organic solvent dissolution, obtain epoxy resin solution, polyamines is dissolved in the second organic solvent, the polyamines solution of acquisition is added drop-wise in epoxy resin again, dropwise, stir pressure reducing and steaming solvent after 1-2 hour, obtain epoxy resin polyamines polymer;

Second step, a step preparing phosphate Gemini surface active agent, in epoxy resin polyamines polymer, add phosphorous acid and hydrochloric acid, be warming up to 70 ~ 80 DEG C, in system, drip formalin, stir after 1 ~ 2 hour and cool, there is insoluble matter to separate out, pour out clear liquid, with vigorous stirring, inside system, drip sodium hydroxide solution, system is gradually clarified and is obtained phosphate double sub-surface activator solution.

7. a kind of Chinese herbal medicine whitening cream as claimed in claim 6, is characterized in that: described first organic solvent is the combination of one or more in C1 ~ C3 alcohol, and described epoxy resin and the weight ratio of organic solvent are 2.0:1 ~ 4.0:1.

8. a kind of Chinese herbal medicine whitening cream as claimed in claim 6, it is characterized in that: described polyamines is ethylenediamine, diethylenetriamine, triethylene tetramine or TEPA, the second described organic solvent is one or more in C1 ~ C3 alcohol, and the weight ratio of polyamines and the second organic solvent is 1.0:1 ~ 2.0:1.

9. a kind of Chinese herbal medicine whitening cream as claimed in claim 6, is characterized in that: in described epoxy resin, the molal quantity of epoxy is 1:1.2 ~ 1.8 with the ratio of the molal quantity of polyamines.

10. a kind of Chinese herbal medicine whitening cream as claimed in claim 6, it is characterized in that: in described phosphorous acid and polyamines, the mol ratio of nitrogen-atoms is 1.1 ~ 1.5:1, the mol ratio of formaldehyde and phosphorous acid is 1.2 ~ 1.8:1, the mol ratio of hydrochloric acid and phosphorous acid is 1.0 ~ 3.0:1, and in sodium hydroxide and polyamines, the mol ratio of nitrogen-atoms is 1.0:1.

The preparation method of 11. a kind of Chinese herbal medicine whitening creams according to claim 1, is characterized in that comprising the following steps:

The first step, prepares described extracts of Chinese herbal medicine;

Second step, takes each material according to weight ratio, and vaseline, tristerin, surfactant are placed in a container, and be heated to melting, temperature remains on 85-95 DEG C, obtains oil phase;

3rd step, is scattered in extracts of Chinese herbal medicine in propylene glycol, adds water, and stirring makes it dispersion, is then heated to 60 ~ 70 DEG C, and stirring and dissolving 30 ~ 60min, to transparent clarification shape, leaves standstill to remove blibbing; Be cooled to 30 ~ 40 DEG C, transparent liquid viscosity to be dissolved increases and starts, in emulsion form, to add the oil phase that second step obtains, and continues stirring 30 ~ 45min, namely obtains paste finished product after leaving standstill 12 ~ 24h.

The preparation method of 12. a kind of Chinese herbal medicine whitening creams as claimed in claim 11, is characterized in that the preparation method of described extracts of Chinese herbal medicine comprises the following steps:

The first step, pulverizes respectively by crude drug, puts into a container and mixes, obtain mixture, add the distilled water of 8 ~ 10 times of mixture qualities, and after soaking 5 ~ 6h, heated and boiled 3 ~ 4h, filters, and obtains first time filtrate;

Second step, filtering the distilled water again adding the quality of 6 ~ 8 times of mixture in the filtering residue obtained, heated and boiled 2 ~ 3h, second time is filtered, and obtains second time filtrate;

3rd step, filters the distilled water adding the quality of 4 ~ 6 times of mixture in the filtering residue obtained again, heated and boiled 1 ~ 2h in second time, third time filters, and obtains third time filtrate;

4th step, merges above-mentioned three filtrate, again filters, obtain filtrate, concentrates and obtains extracts of Chinese herbal medicine.