CN104698196A - Counting pond assembly for five differential hematology analyzers and blood sample distribution method - Google Patents
Counting pond assembly for five differential hematology analyzers and blood sample distribution method Download PDFInfo
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- CN104698196A CN104698196A CN201510096062.1A CN201510096062A CN104698196A CN 104698196 A CN104698196 A CN 104698196A CN 201510096062 A CN201510096062 A CN 201510096062A CN 104698196 A CN104698196 A CN 104698196A
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Abstract
The invention provides a counting pond assembly for five differential hematology analyzers. The counting pond assembly is applied to simplification of internal structures of the five differential hematology analyzers. According to the technical scheme, the counting pond assembly comprises a DIFF pond, an RBC pond, an RINSE pond and a WBC-HGB pond, wherein the WBC-HGB pond is applied to white blood cell counting, basophil cell classification and hemoglobin measurement; and the RINSE pond, the DIFF pond, the RBC pond and the WBC-HGB pond are sequentially connected through a one-piece side-by-side manner. Through implementation of the technical scheme, the preparation cost of an instrument can be reduced, so that the internal assembly space is saved; and the instrument can be fabricated to be relatively miniaturized.
Description
Technical field
The present invention relates to blood analysis technology field, be specifically related to differential hematology analyzer counting chamber assembly and blood sample distribution method.
Background technology
Blood analyser is a kind of specialized equipment of blood being carried out to blood routine examination.Along with the development that analytical technology is maked rapid progress, current blood analyser realizes robotization, and by three original development of categories to five classification.
At present, the analyzing and processing of full-automatic differential hematology analyzer to blood sample (abbreviation blood sample) relates generally to 5 ponds, i.e. DIFF(Differential, classification) pond, WBC(White Blood Cell, leucocyte) pond, HGB(Hemoglobin, haemoglobin) pond, RBC(Red Blood Cell, red blood cell) pond and RINSE(rinse) pond.Wherein, DIFF pond carries out four classification for adopting optical absorption method and electrical conductance method to leucocyte: classification hemolytic agent lysed erythrocyte, leucocyte is dyeed, after a period of time, staining reaction stops by the dilution added subsequently, and instrument, by measuring leukocytic volume and absorbance value, distinguishes lymphocyte, monocyte, eosinophil and neutrophil leucocyte four hive off.WBC pond is used for white blood cell count(WBC) and basocyte classification: blood sample mixes with a certain amount of basophilic hemolytic agent, red blood cell is dissolved by hemolytic agent, except basophilic granulocyte, there is significant contraction in other leucocytes, and basophilic granulocyte exists as maxicell, distinguish basophilic granulocyte and other leucocytes by measurement volumes (impedance method).HGB pond is used for hemoglobinometry: the surfactant in haemoglobin hemolytic agent destroys erythrocytic cell membrane, haemoglobin is released, and be oxidized to methemoglobin, stable derivant is formed with hemolytic agent, this derivant has absorption maximum performance under 540nm wavelength, and instrument can calculate content of hemoglobin by detecting absorption peak size.RBC pond is used for carrying out RBC(red blood cell) and PLT(Platelet, blood platelet) counting: dilution is a kind of damping fluid with certain conductivity, can dilute blood sample, original form can be kept within a certain period of time after haemocyte is diluted, therefore, dilution may be used for counting red blood cell and blood platelet etc.RINSE pond is used for liquid waste processing, needle body cleaning etc.
Technique scheme employs 5 ponds, certainly will need to use a great deal of multiple parts supporting with it, as syringe and solenoid valve.This not only adds instrument manufacturing cost, also need to expend more assembly space, make instrument volume larger.
Summary of the invention
In order to solve the problem, the invention provides a kind of differential hematology analyzer counting chamber assembly and blood sample distribution method, for simplifying differential hematology analyzer inner structure, by implementing technical solution of the present invention, instrumentation cost can be saved, and save mounted inside space, instrument can be made more miniaturization.
Differential hematology analyzer counting chamber assembly, comprising: DIFF pond, RBC pond and RINSE pond, also comprise:
WBC-HGB pond, for white blood cell count(WBC), basocyte classification and hemoglobinometry;
Wherein, described RINSE pond, described DIFF pond, described RBC pond are connected by conjuncted side-by-side configuration successively with described WBC-HGB pond.
A kind of differential hematology analyzer, comprise counting chamber assembly as above, described differential hematology analyzer uses described counting chamber assembly to carry out blood analysis operation.
A kind of blood sample distribution method, be applied to differential hematology analyzer, described five classification analysis instrument comprise counting chamber assembly as above, comprising:
The quantitative blood sample of sampling needle collection;
The blood sample of the first quota is injected WBC-HGB pond by described sampling needle, makes blood sample and dilution be mixed to form the first mixed liquor;
The blood sample of the second quota is injected DIFF pond by described sampling needle, and make blood sample and hemolytic agent be mixed to form the second mixed liquor, described first quota and described second quota sum are less than quantitatively described;
Described sampling needle collecting part first mixed liquor from described WBC-HGB pond also all injects RBC pond, makes described part first mixed liquor and dilution be mixed to form the 3rd mixed liquor.
The invention has the beneficial effects as follows, the improvement of reagents, a WBC-HGB pond is merged in WBC pond and HGB pond, the classification of white blood cell count(WBC), basocyte and hemoglobinometry can be carried out in same pond simultaneously, simplified differential hematology analyzer inner structure.By implement technical solution of the present invention, instrumentation cost can be saved, and save mounted inside space, instrument can be made more miniaturization.
Accompanying drawing explanation
Fig. 1 is the counting chamber component integration schematic diagram of the embodiment of the present invention;
Fig. 2 is the WBC-HGB pool structure schematic diagram of the embodiment of the present invention;
Fig. 3 is the blood sample distribution method process flow diagram of the embodiment of the present invention;
Fig. 4 is the blood sample distribution method process flow diagram of another embodiment of the present invention.
Embodiment
Below in conjunction with the Figure of description in the present invention, be clearly and completely described the technical scheme in invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
The embodiment of the present invention will be described in detail to a kind of differential hematology analyzer counting chamber assembly.Counting chamber assembly described in the present embodiment is applicable to based on optical absorption method and impedance method (also known as Coulter principle), and adopts five classification analysis instrument of two sheath Flow Technique.This counting chamber assembly is installed on instrument internal, is mainly used in blood sample Data Detection.
Refer to Fig. 1, counting chamber assembly mainly comprises 4 ponds, is from left to right followed successively by RINSE pond 10, DIFF pond 20, RBC pond 30 and WBC-HGB pond 40.
Wherein, as shown in Figure 1, RINSE pond 10, DIFF pond 20, RBC pond 30 are connected by conjuncted side-by-side configuration successively with WBC-HGB pond 40.Connected mode can be plural one-body moldedly to connect again, also can be independent connection, also can be all one-body molded, not do concrete restriction here.In other multiple embodiment, 4 ponds of counting chamber assembly can be connected by conjuncted side-by-side configuration with other order arbitrary, repeat no more here.
Identical with RBC pond with the RINSE pond described in background technology, DIFF pond, RINSE pond 10 in the present embodiment is also for liquid waste processing, needle body cleaning etc., DIFF pond 20 is also for adopting optical absorption method and electrical impedance method to carry out four classification to leucocyte, and RBC pond 30 is also for carrying out RBC and PLT counting.Unlike, WBC-HGB pond 40 is for white blood cell count(WBC), basocyte classification and hemoglobinometry.WBC-HGB pond 40 coordinates a kind of reagent newly developed to use, surfactant in this reagent destroys erythrocytic cell membrane, haemoglobin is released, and be oxidized to methemoglobin, stable derivant is formed with hemolytic agent, this derivant has absorption maximum performance under 540nm wavelength, instrument can calculate content of hemoglobin by detecting absorption peak size, simultaneously, blood sample mixes with the basophilic hemolytic agent in this reagent, red blood cell is dissolved by hemolytic agent, except basophilic granulocyte, there is significant contraction in other leucocytes, and basophilic granulocyte exists as maxicell, basophilic granulocyte and other leucocytes are distinguished by measurement volumes (impedance method).
In the present embodiment, the improvement of reagents, a WBC-HGB pond is merged in WBC pond of the prior art and HGB pond, the classification of white blood cell count(WBC), basocyte and hemoglobinometry can be carried out in same pond simultaneously, simplified differential hematology analyzer inner structure.By implement technical solution of the present invention, instrumentation cost can be saved, thus save mounted inside space, instrument can be made more miniaturization.
Embodiment is described in detail to the concrete structure in WBC-HGB pond 40 below.
Refer to Fig. 2, WBC-HGB pond 40 comprises: body 401, count section installation position 402, installation position, optics portion 403 and insulated chamber 404.
Body 401 is funnel-shaped structure, and upper end is circular open, and lower end is punctured into a small pipeline.Body 401 is light-transmitting materials, or at least partly specific region is light-transmitting materials, irradiates by realize optical absorption method for light.In addition, the small pipeline of body 401 lower end connects insulated chamber 404.
The upper cover part of insulated chamber 404 can be one-body molded with body 401.Insulated chamber 404 plays a part to isolate gas, liquid, also for temporary waste liquid.
Installation position, optics portion 403 is arranged at the position near the outlet of body 401 lower end, for being installed into the optics portion of row hemoglobinometry.Installation position, optics portion 403 comprises 2 installation positions, and corresponding emission part and the acceptance division installing optics portion, these 2 installation positions lay respectively at the relative both sides of body 401 outer wall.At present, emission part is particularly suited for using LED(light emitting diode), optimum emission wavelength is 540nm, and acceptance division specifically uses photodiode.
Count section installation position 402 is arranged at position, installation position more than 403, optics portion, for installing the count section of carrying out white blood cell count(WBC) and basocyte classification.Count section comprises counting hole (also known as gem hole) and electrode to realize electrical impedance method.
Preferably, as shown in Figure 2, WBC-HGB pond 40 also comprises: cleaning liquor pipe 405, dilute liquid conduit 406 and hemolytic agent conduit 407.
Cleaning liquor pipe 405 and dilute liquid conduit 406 are all arranged at the position near body 401 upper end open.Cleaning liquor pipe 405 is for injecting cleaning fluid, and dilute liquid conduit 406 is for injecting dilution.
Particularly, one end of being connected with body 401 of cleaning liquor pipe 405 is higher than its other end.One end that dilute liquid conduit 406 is connected with body 401 is lower than its other end.Cleaning liquor pipe 405 reality is a kind of feed liquor mode obliquely, can increase cleaning fluid area coverage, abundant rinse, thus makes body 401 inner wall washing more thorough, ensures the accuracy of test result.Dilute liquid conduit 406 reality is a kind of feed liquor mode obliquely, can realize reagent and blood sample tangent stream mixes.
Hemolytic agent conduit 407 is horizontally placed on and connects the outlet of body 401 lower end, for injecting hemolytic agent liquid.
In one embodiment, a kind of differential hematology analyzer uses the counting chamber assembly described in above-described embodiment to carry out blood analysis operation.
Another embodiment will be described in detail to a kind of blood sample distribution method, and the method is applied to differential hematology analyzer, and this differential hematology analyzer uses the counting chamber assembly described in above-described embodiment to carry out blood analysis operation equally.Refer to Fig. 3, the present embodiment method comprises step:
301, the quantitative blood sample of sampling needle collection.
Sampling needle gathers quantitative blood sample from blood sample test tube, as N microlitre.
302, the blood sample of the first quota is injected WBC-HGB pond by sampling needle, makes blood sample and dilution be mixed to form the first mixed liquor.
Sampling needle moves to directly over counting chamber assembly, is specially directly over WBC-HGB pond, the blood sample of the first quota is injected WBC-HGB pond, injects dilution simultaneously, be mixed into the first mixed liquor.This first quota is assumed to be m microlitre, and the first mixed liquor is M microlitre.
303, the blood sample of the second quota is injected DIFF pond by sampling needle, makes blood sample and hemolytic agent be mixed to form the second mixed liquor.
Sampling needle rises and moves to directly over DIFF pond, the blood sample of the second quota is injected DIFF, injects hemolytic agent simultaneously, be mixed into the second mixed liquor.This second quota is assumed to be p microlitre, and the second mixed liquor is P microlitre.
Wherein, the first quota and the second quota sum are less than that this is quantitative.In the present embodiment, i.e. m+p<N.After completing this step, it is emptying that collection pin will remain blood sample.
304, sampling needle collecting part first mixed liquor from WBC-HGB pond also all injects RBC pond, makes part first mixed liquor and dilution be mixed to form the 3rd mixed liquor.
Sampling needle rises and moves to WBC-HGB Chi Chu, and from WBC-HGB pond, collecting part first mixed liquor also all injects RBC pond, injects dilution simultaneously, is mixed into the 3rd mixed liquor.This part first mixed liquor is q microlitre, and the 3rd mixed liquor is Q microlitre, remains M-q microlitre first mixed liquor in WBC-HGB pond.
First mixed liquor is used for white blood cell count(WBC), basocyte classification and hemoglobinometry by differential hematology analyzer, second mixed liquor is used for adopt optical absorption method and electrical conductance method to carry out four classification to leucocyte, the 3rd mixed liquor is used for carry out RBC and PLT counting.
After distribution blood sample step completes, differential hematology analyzer can carry out blood analysis operation to the mixed liquor in counting chamber assembly, namely white blood cell count(WBC), basocyte classification and hemoglobinometry are carried out to M-q microlitre first mixed liquor in WBC-HGB pond, adopt optical absorption method and electrical impedance method to carry out four classification to leucocyte to P microlitre second mixed liquor in DIFF pond, RBC and PLT counting is carried out to Q microlitre the 3rd mixed liquor in RBC pond.
In the present embodiment, owing to coordinating the use of aforementioned counting chamber assembly, in blood sample assigning process, sampling needle moves total kilometres and shortens dramatically compared to existing technology, improves analyser whole detection speed, also saves the consumption of reagent.
Another embodiment will be described in detail to a kind of blood sample distribution method, and the method is applied to differential hematology analyzer equally, and this differential hematology analyzer uses the counting chamber assembly described in above-described embodiment to carry out blood analysis operation equally.Refer to Fig. 4, the present embodiment method comprises step:
501, the quantitative blood sample of sampling needle collection.
Sampling needle gathers quantitative blood sample from blood sample test tube, as N microlitre.
Preferably, in the present embodiment, sampling needle does reciprocal rectilinear motion all the time above counting chamber assembly.
502, sampling needle moves to above RINSE pond and carries out needle body cleaning, and the blood sample of first residue is entered RINSE pond.
Needle body cleaning comprises sampling needle outer wall washing, the cleaning also comprising puncture needle simultaneously carried out, and is that a small amount of blood sample of first residue is drained by deal, prevents blood sample from polluting, realizes again accurately control.First residue is set to a.
503, the blood sample of the first quota is injected WBC-HGB pond by sampling needle, makes blood sample and dilution be mixed to form the first mixed liquor.
Sampling needle moves to directly over counting chamber assembly, is specially directly over WBC-HGB pond, the blood sample of the first quota is injected WBC-HGB pond, injects dilution simultaneously, be mixed into the first mixed liquor.This first quota is assumed to be m microlitre, and the first mixed liquor is M microlitre.
504, the blood sample of the second quota is injected DIFF pond by sampling needle, makes blood sample and hemolytic agent be mixed to form the second mixed liquor.
Sampling needle rises and moves to directly over DIFF pond, the blood sample of the second quota is injected DIFF pond, injects hemolytic agent simultaneously, be mixed into the second mixed liquor.This second quota is assumed to be p microlitre, and the second mixed liquor is P microlitre.
505, sampling needle moves to above RINSE pond and carries out needle body cleaning, and the blood sample of the second surplus is entered RINSE pond.
Similar with step 502, needle body cleaning comprises sampling needle outer wall washing, the cleaning also comprising puncture needle simultaneously carried out, and is that a small amount of blood sample of the second surplus is drained by deal, and now in sampling needle, blood sample is drained.Second surplus is set to b.
First quota, the second quota, first residue and the second surplus sum equal quantitatively described.I.e. m+p+a+b=N.
506, sampling needle collecting part first mixed liquor from WBC-HGB pond also all injects RBC pond, makes part first mixed liquor and dilution be mixed to form the 3rd mixed liquor.
Sampling needle rises and moves to WBC-HGB Chi Chu, and from WBC-HGB pond, collecting part first mixed liquor also all injects RBC pond, injects dilution simultaneously, is mixed into the 3rd mixed liquor.This part first mixed liquor is q microlitre, and the 3rd mixed liquor is Q microlitre, remains M-q microlitre first mixed liquor in WBC-HGB pond.
Preferably, the mixing of blood sample and dilution in abovementioned steps, the mixing of blood sample and hemolytic agent, part first mixed liquor all use tangent stream blending manner to mix with mixing of dilution.
First mixed liquor is used for white blood cell count(WBC), basocyte classification and hemoglobinometry by differential hematology analyzer, second mixed liquor is used for adopt optical absorption method and electrical conductance method to carry out four classification to leucocyte, the 3rd mixed liquor is used for carry out RBC and PLT counting.
After distribution blood sample step completes, differential hematology analyzer can carry out blood analysis operation to the mixed liquor in counting chamber assembly, namely white blood cell count(WBC), basocyte classification and hemoglobinometry are carried out to M-q microlitre first mixed liquor in WBC-HGB pond, adopt optical absorption method and electrical impedance method to carry out four classification to leucocyte to P microlitre second mixed liquor in DIFF pond, RBC and PLT counting is carried out to Q microlitre the 3rd mixed liquor in RBC pond.
In the present embodiment, owing to coordinating the use of aforementioned counting chamber assembly, in blood sample assigning process, sampling needle moves total kilometres and shortens dramatically compared to existing technology, improves analyser whole detection speed, also saves the consumption of reagent.
The differential hematology analyzer counting chamber assembly provided the embodiment of the present invention above and blood sample distribution method are described in detail, but the explanation of above embodiment just understands structure of the present invention and core concept thereof for helping, and should not be construed as limitation of the present invention.Those skilled in the art are in the technical scope that the present invention discloses, and the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.
Claims (9)
1. differential hematology analyzer counting chamber assembly, comprising: classification DIFF pond, red blood cell RBC pond and flushing RINSE pond, is characterized in that, also comprise:
Leucocyte-haemoglobin WBC-HGB pond, for white blood cell count(WBC), basocyte classification and hemoglobinometry;
Wherein, described RINSE pond, described DIFF pond, described RBC pond are connected by conjuncted side-by-side configuration successively with described WBC-HGB pond.
2. counting chamber assembly according to claim 1, is characterized in that, described WBC-HGB pond comprises: body, count section installation position, installation position, optics portion and insulated chamber,
Described body is funnel-shaped structure, at least partly light-transmitting materials, and its lower end connects described insulated chamber;
Installation position, described optics portion is arranged at the position near the outlet of described body lower end, for being installed into the optics portion of row hemoglobinometry;
Described count section installation position is arranged at above position, installation position, described optics portion, for installing the count section of carrying out white blood cell count(WBC) and basocyte classification.
3. counting chamber assembly according to claim 1 and 2, is characterized in that, described WBC-HGB pond also comprises: cleaning liquor pipe, dilute liquid conduit and hemolytic agent conduit,
Described cleaning liquor pipe and described dilute liquid conduit are all arranged at the position near described body upper end open, and described cleaning liquor pipe and described body link are higher than its other end, and described dilute liquid conduit and described body link are lower than its other end;
Described hemolytic agent conduit is horizontally placed on and connects the outlet of described body lower end.
4. a differential hematology analyzer, is characterized in that, comprises the counting chamber assembly as described in any one of claims 1 to 3,
Described differential hematology analyzer uses described counting chamber assembly to carry out blood analysis operation.
5. a blood sample distribution method, is applied to differential hematology analyzer, and described five classification analysis instrument comprise the counting chamber assembly as described in any one of claims 1 to 3, it is characterized in that, comprising:
The quantitative blood sample of sampling needle collection;
The blood sample of the first quota is injected WBC-HGB pond by described sampling needle, makes blood sample and dilution be mixed to form the first mixed liquor;
The blood sample of the second quota is injected DIFF pond by described sampling needle, and make blood sample and hemolytic agent be mixed to form the second mixed liquor, described first quota and described second quota sum are less than quantitatively described;
Described sampling needle collecting part first mixed liquor from described WBC-HGB pond also all injects RBC pond, makes described part first mixed liquor and dilution be mixed to form the 3rd mixed liquor.
6. blood sample distribution method according to claim 5, is characterized in that,
Also comprise after the quantitative blood sample of described sampling needle collection:
Described sampling needle moves to above RINSE pond and carries out needle body cleaning, and the blood sample of first residue is entered described RINSE pond;
Described sampling needle also comprises after the blood sample of the second quota is injected DIFF pond:
Described sampling needle moves to above described RINSE pond and carries out needle body cleaning, and the blood sample of the second surplus is entered described RINSE pond;
Wherein, described first quota, described second quota, described first residue and described second surplus sum equal quantitatively described.
7. the blood sample distribution method according to claim 5 or 6, is characterized in that,
Described sampling needle does reciprocal rectilinear motion all the time above described counting chamber assembly.
8. the blood sample distribution method according to claim 5 or 6, is characterized in that,
Described blood sample mixes with dilution, described blood sample mixes with hemolytic agent, described part first mixed liquor mixes with dilution and all uses tangent stream blending manner to mix.
9. the blood sample distribution method according to claim 5 or 6, is characterized in that,
Described first mixed liquor is used for white blood cell count(WBC), basocyte classification and hemoglobinometry by described differential hematology analyzer, described second mixed liquor is used for adopt optical absorption method and electrical conductance method to carry out four classification to leucocyte, described 3rd mixed liquor is used for carry out RBC and PLT counting.
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| CN110073197A (en) * | 2016-12-15 | 2019-07-30 | 株式会社堀场制作所 | Grain count device |
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Application publication date: 20150610 |