CN104689775A - Droplet type micro-fluidic chip and method of preparing PVDF (Polyvinylidene Fluoride)-Fe 3O4 magnetic-electric composite microspheres by using the same - Google Patents
Droplet type micro-fluidic chip and method of preparing PVDF (Polyvinylidene Fluoride)-Fe 3O4 magnetic-electric composite microspheres by using the same Download PDFInfo
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Abstract
A droplet type micro-fluidic chip comprises a dispersion-phase channel, two continuous-phase channels and a synthesis channel; the two continuous-phase channels are distributed at two sides of the dispersion-phase channel; the dispersion-phase channel, the continuous-phase channels and the synthesis channel are all provided with input ports and output ports; and the input ports of the continuous-phase channels and the dispersion-phase channel are jointed at the input port of the synthesis channel. The preparation method of PVDF (Polyvinylidene Fluoride)-Fe 3O4 magnetic-electric composite microspheres comprises the steps: uniformly mixing PEG-DA, 2-hydroxy-2-methyl-1-phenyl-1-acetone, Fe 3O4 nano particles and PVDF solution into a dispersion phase; utilizing soybean oil as a continuous phase, respectively injecting the dispersion phase and the continuous phase via the input ports of the dispersion-phase channel and the continuous-phase channels, keeping the flow rate of the continuous phase to be higher than the flow rate of the dispersion phase and forming PVDF-Fe 3O4 composite micro droplets; irradiating the PVDF-Fe 3O4 composite micro droplets with ultraviolet light during motion in the synthesis channel, thereby obtaining the PVDF-Fe 3O4 magnetic-electric composite microspheres. The advantages are as follows: the droplet type micro-fluidic chip is simple in structure; and the prepared magnetic-electric composite microspheres are uniform and controllable in size and strong in stability.
Description
Technical field
The present invention relates to a kind of drop type micro-fluidic chip and utilize it to prepare PVDF-Fe
3o
4the method of magnetoelectricity complex microsphere, belongs to micro-total analysis system field.
Background technology
Magnetic electric compound material is a kind of new function material ferroelectric substance and ferrimagnet are compounded to form through certain method, not only has the former piezo-electric effect and the magnetostrictive effect of the latter, and can also produce new magnetoelectric effect.Relative to single-phase magnetic electric material, magnetic electric compound material has the plurality of advantages such as Neel and Curie temperature is high, magnetoelectricity conversion coefficient is large, has huge application prospect in fields such as intelligent filter, magnetoelectric transducer, magnetic sensors.And in these magnetic electric compound materials, Kynoar (PVDF) has good piezoelectric property, tri-iron tetroxide (Fe
3o
4) there is good magnetic, therefore prepare PVDF-Fe
3o
4compound magnetoelectric material causes researcher and studies interest widely.At present, the PVDF-Fe of film-form is mainly prepared in tradition research
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4magnetic electric compound material, and utilize conventional art to prepare the PVDF-Fe of synthesis
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4micro materials also exists complicated operation, size heterogeneity and the limitation such as uncontrollable, and microflow control technique provides a good technology platform for overcoming the problems referred to above.
Microfluidic chip technology originates from the nineties in 20th century, be applied to analytical chemistry field at first, it is architectural feature with microchannel, take life science as main study subject, by micro-electromechanical processing technology (MEMS), the function in whole laboratory is comprised print pretreatment, reaction, separation, detection etc. to be integrated on the chip of one piece of micro-meter scale, analysis speed is greatly improved, has integrated level high, reagent consumption is few, cost of manufacture is low, analysis efficiency high.In current microflow control technique, micro-fluidic being more and more applied to of drop prepares multi-functional material.The major advantage of this technology is: component and the ratio thereof that 1, accurately can control synthetic material; 2, the size by regulating each phase flow velocity can control synthetic material easily; 3, compared with conventional method, the microparticle size utilizing drop microfluidic chip technology to synthesize has good homogeneity.But, utilize drop micro-fluidic chip to prepare the research of the method for magnetic electric compound material at present little.
Summary of the invention
The object of this invention is to provide a kind of drop type micro-fluidic chip and utilize it to prepare PVDF-Fe
3o
4the method of magnetoelectricity complex microsphere, magnetic electric compound material prepared by the method belongs to micro-meter scale, and size is homogeneous, controlled.
For reaching above object, the present invention by the following technical solutions:
A kind of drop type micro-fluidic chip, comprise decentralized photo raceway groove, two continuous phase raceway grooves and synthesis raceway groove, two continuous phase raceway grooves are distributed in the both sides of decentralized photo raceway groove, continuous phase raceway groove, decentralized photo raceway groove and synthesis raceway groove all have input port and delivery outlet, and the delivery outlet of continuous phase raceway groove and decentralized photo raceway groove crosses at the input port place of synthesis raceway groove.
The diameter of described decentralized photo raceway groove is 30-100 micron, and the diameter of continuous phase raceway groove is 30-100 micron, and the diameter of synthesis raceway groove is 50-200 micron.
Described two continuous phase raceway grooves share an input port.
Described synthesis raceway groove is straight flute road.
The length in described straight flute road is 1000 ~ 3000 microns.
One utilizes above-mentioned drop type micro-fluidic chip to prepare PVDF-Fe
3o
4the method of magnetoelectricity complex microsphere, comprises the steps:
(1) configuration quality mark is the PVDF solution of 5% ~ 10%;
(2) by PEG-DA, 2-hydroxy-2-methyl-1-phenyl-1-acetone, Fe
3o
4the PVDF solution that nano particle is prepared with step (1) mixes, as decentralized photo;
(3) take soybean oil as continuous phase, the flow velocity of continuous phase by 10 ~ 500 micro-ls/h is injected from continuous phase raceway groove input port, decentralized photo step (2) prepared injects from the input port of decentralized photo raceway groove by the flow velocity of 1 ~ 100 micro-l/h, and keep the flow velocity of flow velocity higher than decentralized photo of continuous phase, form PVDF-Fe in synthesis raceway groove porch
3o
4compound microlayer model;
(4) PVDF-Fe for preparing of step (3)
3o
4in the process that compound microlayer model moves in synthesis raceway groove, UV-irradiation is carried out to it, forms PVDF-Fe
3o
4complex microsphere.
The solvent of described PVDF solution is dimethyl formamide or dimethylacetylamide.
Described Fe
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4the diameter of nano particle is 200nm ~ 300nm.
Described PEG-DA, 2-hydroxy-2-methyl-1-phenyl-1-acetone, Fe
3o
4the mass ratio of nano particle and PVDF solution is 34:6:10:50.
Above-mentioned micro-fluidic chip can make by the following method: by raceway groove graphic making photo etched mask; Silicon chip or sheet glass are the photoresist of 10-100 micron with spin coating method coating thickness, dry; Utilize standard photolithography process to carry out photoetching, development, dry; Utilize the photoresist of silicon chip projection for formpiston, perfusion high molecular polymer, solidification; Take the polymeric colloid being printed on channel pattern off, carry out surface oxidation treatment after punching, polymer raceway groove face and new sheet glass bonding, obtain polymeric micro-fluidic chip.
Present invention also offers and utilize above-mentioned micro-fluidic chip to prepare PVDF-Fe
3o
4the method of magnetoelectricity complex microsphere: configuration quality mark is the PVDF solution of 5% ~ 10%, solvent is dimethyl formamide (DMF) or dimethylacetylamide (DMAc).Then based on the reaction of the uv photopolymerization of PEG-DA (wherein PEG-DA is uv photopolymerization monomer, and 2-hydroxy-2-methyl-1-phenyl-1-acetone (Darocur 1173) is light trigger), by PEG-DA, Darocur 1173, PVDF/DMF, Fe
3o
4the mixed solution of nano particle (diameter is 200nm ~ 300nm) as decentralized photo, and makes soybean oil as continuous phase.The flow velocity of continuous phase by 10 ~ 500 micro-ls/h is injected from continuous phase raceway groove input port, the flow velocity of decentralized photo by 1 ~ 100 micro-l/h is injected from the input port of decentralized photo raceway groove, and keeps the flow velocity of flow velocity higher than decentralized photo of continuous phase.Continuous phase is by the stream focusing structure of above-mentioned continuous phase raceway groove, make decentralized photo at synthesis raceway groove input port place because squeezing action forms one stable focused flow, and focused flow is due to surface tension, the effect pulling power and shearing force, head is fracture periodically, produces uniformly to include PVDF polymer and Fe
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4the micro polymer drop of nano particle.This structure polymer microballoon preparation in for realizing oily encapsulation reaction solution, with realize reaction solution formed size homogeneous, the micro polymer drop that speed is certain.In the process that this micro polymer drop flows in synthesis raceway groove, by applying ultraviolet light, the photo polymerization monomer of drop internal and light trigger are reacted, solidify to form polymer microballoon by microlayer model, finally can obtain the PVDF-Fe with stable form from synthesis channel outlets
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4magnetoelectricity complex microsphere.
The present invention is first using the magnetic Fe of tool as decentralized photo
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4the controlled microlayer model including magnetoelectric material of size is prepared in the effect pulling power and shearing force by continuous phase with the mixed solution of the PVDF material of piezoelectricity, and controllable diameter scope is about 10-100 micron, and size fluctuation is less than 1%.The size of adjustment continuous phase flow velocity can control size and the spacing of microlayer model effectively, prevents it from mutually colliding, merges.And sufficiently long synthesis raceway groove can provide time enough for the magnetoelectricity complex microsphere that is solidified into further of microlayer model.
For preparing different size size micro polymer drop, can be realized by the flow velocity changing oil speed and decentralized photo magnetoelectricity mixed solution.
Compared with prior art, advantage of the present invention is:
(1) drop type microfluidic chip structure provided by the invention is simple, and preparation method is simple.
(2) drop type micro-fluidic chip provided by the invention has sufficiently long synthesis raceway groove and can provide time enough for the magnetoelectricity complex microsphere that is solidified into further of microlayer model.
(3) homogeneous controlled, the comparatively narrow size distribution (CV% is less than 5%) of the magnetic electric compound material microballoon size prepared of the present invention, be shaped better, stability is strong, reproducible, can be applicable to large-scale production.
Accompanying drawing explanation
Fig. 1 is the structural representation of drop type micro-fluidic chip of the present invention; Wherein, 1-continuous phase raceway groove, 2-decentralized photo raceway groove, 3-synthesizes raceway groove, 4-continuous phase raceway groove input port, 5-decentralized photo raceway groove input port, and 6-synthesizes raceway groove input port, 7-continuous phase raceway groove delivery outlet, 8-continuous phase raceway groove delivery outlet, and 9-synthesizes raceway groove delivery outlet.
Fig. 2 is the PVDF-Fe that embodiment 1 utilizes drop micro-fluidic chip and prepares
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4the electromicroscopic photograph of complex microsphere.
Fig. 3 is decentralized photo flow velocity and PVDF-Fe in embodiment 2
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4the graph of a relation of complex microsphere diameter.
Fig. 4 is continuous phase flow velocity and PVDF-Fe in embodiment 2
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4the graph of a relation of complex microsphere diameter.
Detailed description of the invention
Now with the tri-iron tetroxide (Fe of the Kynoar (PVDF) and magnetic with good piezoelectricity
3o
4) based on material, the ultra-violet curing by means of polyethyleneglycol diacrylate (PEG-DA) reacts, and illustrates embodiment of the present invention.
embodiment 1
Drop type micro-fluidic chip: see accompanying drawing 1, drop type micro-fluidic chip of the present invention, comprise two continuous phase raceway grooves, 1, decentralized photo raceway groove 2 and a synthesis raceway groove 3, continuous phase raceway groove 1, decentralized photo raceway groove 2 and synthesis raceway groove 3 have input port 4,5,6 and delivery outlet 7,8,9, described continuous phase raceway groove 1 is distributed in decentralized photo raceway groove 2 both sides, and continuous phase raceway groove 1 and decentralized photo raceway groove 2 export 7,8 and cross at input port 6 place of synthesis raceway groove 3.The diameter of decentralized photo raceway groove 2 is 30-100 micron, and the diameter of continuous phase raceway groove 1 is 30-100 micron, and the raceway diameter of synthesis raceway groove 3 is 50-200 micron.
Two continuous phase raceway grooves 1 share an input port 4.
Described synthesis raceway groove is segment length's straight flute road, length is 1000 ~ 3000 microns, guarantee that enough time has the microparticle of stable form to make microlayer model solidify to form, realize the preparation of magnetic electric compound material microballoon, and collect gained polymerizing microballoons from the exit of synthesis raceway groove.
Above-mentioned drop type micro-fluidic chip is utilized to prepare PVDF-Fe
3o
4magnetoelectricity complex microsphere, and with PVDF and Fe
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4based on material, uv photopolymerization by means of polyethyleneglycol diacrylate (PEG-DA) reacts that (wherein PEG-DA is uv photopolymerization monomer, 2-hydroxy-2-methyl-1-phenyl-1-acetone (Darocur 1173) is light trigger), preparation has the PVDF-Fe of magneto-electric behavior
3o
4complex microsphere.Concrete steps are as follows:
(1) prepare the PVDF/DMF solution that mass fraction is 10%, wherein dimethyl formamide (DMF) is solvent;
(2) by PEG-DA, Darocur 1173, PVDF/DMF solution and Fe
3o
4nano particle mixes, and forms mixed solution, as decentralized photo, and wherein PEG-DA, Darocur 1173, PVDF/DMF solution and Fe
3o
4the mass fraction percentage that nano particle accounts for mixed solution is respectively 34%, 6%, 50%, 10%;
(3) using soybean oil as continuous phase, adopt above-mentioned drop type microfluidic chip structure, preparation has the PVDF-Fe of magneto-electric behavior
3o
4during complex microsphere, the flow velocity of above-mentioned decentralized photo mixed solution by 11 micro-ls/h is injected from continuous phase raceway groove input port, the flow velocity of continuous phase soybean oil by 150 micro-ls/h is injected from the input port of decentralized photo raceway groove, and keeps the flow velocity of flow velocity higher than decentralized photo of continuous phase.When two-phase liquid passes through the stream focusing structure of said chip, make decentralized photo at synthesis raceway groove input port 7 place because the squeezing action being subject to continuous phase liquid forms one stable focused flow, and focused flow is due to surface tension, the effect pulling power and shearing force, head is fracture periodically, produces uniform PVDF-Fe
3o
4compound microlayer model.
(4) at PVDF-Fe
3o
4in the process that compound microlayer model moves in synthesis raceway groove, ultraviolet light is applied to it, makes the Darocur 1173 in microlayer model cause the solidification of PEG-DA, thus make microlayer model solidify to form the microballoon with rock-steady structure, obtain PVDF-Fe
3o
4complex microsphere, its electromicroscopic photograph as shown in Figure 2, as can be seen from the figure, prepared PVDF-Fe
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4complex microsphere size uniformity, be shaped better, stability is strong, reproducible.
embodiment 2
As different from Example 1: continuous phase flow velocity is 150 micro-ls/h, setting decentralized photo flow velocity is respectively 5,7,9,11,13,15 micro-ls/h, surveys the diameter of thus obtained microsphere, decentralized photo flow velocity and PVDF-Fe
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4as shown in Figure 3, as can be seen from Figure 3, the flow velocity of decentralized photo is larger, PVDF-Fe for the graph of a relation of complex microsphere diameter
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4the diameter of complex microsphere is larger.
Meanwhile, when determining continuous phase flow velocity difference, prepared PVDF-Fe
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4the diameter of complex microsphere.
Decentralized photo flow velocity is 11 micro-ls/h, and setting continuous phase flow velocity is respectively 50,100,150,200,250,300 micro-ls/h, surveys diameter and the relation of gained micron particles, continuous phase flow velocity and PVDF-Fe
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4as shown in Figure 4, as can be seen from Figure 4, the flow velocity of continuous phase is larger, PVDF-Fe for the graph of a relation of complex microsphere diameter
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4the diameter of complex microsphere is less.
As can be seen here, the flow velocity by changing continuous phase and decentralized photo magnetoelectricity mixed solution can prepare the PVDF-Fe of different size size
3o
4complex microsphere.
embodiment 3
(1) prepare the PVDF/DMF solution that mass fraction is 5%, wherein dimethyl formamide (DMF) is solvent;
(2) by PEG-DA, Darocur 1173, PVDF/DMF solution and Fe
3o
4nano particle mixes, and forms mixed solution, as decentralized photo, and wherein PEG-DA, Darocur 1173, PVDF/DMF solution and Fe
3o
4the mass fraction percentage that nano particle accounts for mixed solution is respectively 34%, 6%, 50%, 10%;
(3) using soybean oil as continuous phase, adopt above-mentioned drop type microfluidic chip structure, preparation has the PVDF-Fe of magneto-electric behavior
3o
4during complex microsphere, the flow velocity of above-mentioned decentralized photo mixed solution by 1 micro-l/h is injected from continuous phase raceway groove input port, the flow velocity of continuous phase soybean oil by 10 micro-ls/h is injected from the input port of decentralized photo raceway groove, and keeps the flow velocity of flow velocity higher than decentralized photo of continuous phase.When two-phase liquid passes through the stream focusing structure of said chip, make decentralized photo at synthesis raceway groove input port 7 place because the squeezing action being subject to continuous phase liquid forms one stable focused flow, and focused flow is due to surface tension, the effect pulling power and shearing force, head is fracture periodically, produces uniform PVDF-Fe
3o
4compound microlayer model.
(4) at PVDF-Fe
3o
4in the process that compound microlayer model moves in synthesis raceway groove, ultraviolet light is applied to it, makes the Darocur 1173 in microlayer model cause the solidification of PEG-DA, thus make microlayer model solidify to form the microballoon with rock-steady structure, obtain PVDF-Fe
3o
4complex microsphere.
embodiment 4
(1) prepare the PVDF/ DMAc solution that mass fraction is 8%, wherein dimethylacetylamide (DMAc) is solvent;
(2) by PEG-DA, Darocur 1173, PVDF/DMF solution and Fe
3o
4nano particle mixes, and forms mixed solution, as decentralized photo, and wherein PEG-DA, Darocur 1173, PVDF/DMF solution and Fe
3o
4the mass fraction percentage that nano particle accounts for mixed solution is respectively 34%, 6%, 50%, 10%;
(3) using soybean oil as continuous phase, adopt above-mentioned drop type microfluidic chip structure, preparation has the PVDF-Fe of magneto-electric behavior
3o
4during complex microsphere, the flow velocity of above-mentioned decentralized photo mixed solution by 100 micro-ls/h is injected from continuous phase raceway groove input port, the flow velocity of continuous phase soybean oil by 500 micro-ls/h is injected from the input port of decentralized photo raceway groove, and keeps the flow velocity of flow velocity higher than decentralized photo of continuous phase.When two-phase liquid passes through the stream focusing structure of said chip, make decentralized photo at synthesis raceway groove input port 7 place because the squeezing action being subject to continuous phase liquid forms one stable focused flow, and focused flow is due to surface tension, the effect pulling power and shearing force, head is fracture periodically, produces uniform PVDF-Fe
3o
4compound microlayer model.
(4) at PVDF-Fe
3o
4in the process that compound microlayer model moves in synthesis raceway groove, ultraviolet light is applied to it, makes the Darocur 1173 in microlayer model cause the solidification of PEG-DA, thus make microlayer model solidify to form the microballoon with rock-steady structure, obtain PVDF-Fe
3o
4complex microsphere.
Claims (9)
1. a drop type micro-fluidic chip, it is characterized in that: comprise decentralized photo raceway groove, two continuous phase raceway grooves and synthesis raceway groove, two continuous phase raceway grooves are distributed in the both sides of decentralized photo raceway groove, continuous phase raceway groove, decentralized photo raceway groove and synthesis raceway groove all have input port and delivery outlet, and the delivery outlet of continuous phase raceway groove and decentralized photo raceway groove crosses at the input port place of synthesis raceway groove.
2. a kind of drop type micro-fluidic chip according to claim 1, it is characterized in that: the diameter of described decentralized photo raceway groove is 30-100 micron, the diameter of continuous phase raceway groove is 30-100 micron, and the diameter of synthesis raceway groove is 50-200 micron.
3. a kind of drop type micro-fluidic chip according to claim 1 or 2, is characterized in that: described two continuous phase raceway grooves share an input port.
4. a kind of drop type micro-fluidic chip according to claim 3, is characterized in that: described synthesis raceway groove is straight flute road.
5. a kind of drop type micro-fluidic chip according to claim 4, is characterized in that: the length in described straight flute road is 1000 ~ 3000 microns.
6. one kind utilizes drop type micro-fluidic chip described in any one of claim 1-5 to prepare PVDF-Fe
3o
4the method of magnetoelectricity complex microsphere, is characterized in that comprising the steps:
(1) configuration quality mark is the PVDF solution of 5% ~ 10%;
(2) by PEG-DA, 2-hydroxy-2-methyl-1-phenyl-1-acetone, Fe
3o
4the PVDF solution that nano particle is prepared with step (1) mixes, as decentralized photo;
(3) take soybean oil as continuous phase, the flow velocity of continuous phase by 10 ~ 500 micro-ls/h is injected from continuous phase raceway groove input port, decentralized photo step (2) prepared injects from the input port of decentralized photo raceway groove by the flow velocity of 1 ~ 100 micro-l/h, and keep the flow velocity of flow velocity higher than decentralized photo of continuous phase, form PVDF-Fe in synthesis raceway groove porch
3o
4compound microlayer model;
(4) PVDF-Fe for preparing of step (3)
3o
4in the process that compound microlayer model moves in synthesis raceway groove, UV-irradiation is carried out to it, forms PVDF-Fe
3o
4complex microsphere.
7. a kind of PVDF-Fe according to claim 6
3o
4the preparation method of magnetoelectricity complex microsphere, is characterized in that: the solvent of described PVDF solution is dimethyl formamide or dimethylacetylamide.
8. a kind of PVDF-Fe according to claim 6 or 7
3o
4the preparation method of magnetoelectricity complex microsphere, is characterized in that: described Fe
3o
4the diameter of nano particle is 200nm ~ 300nm.
9. a kind of PVDF-Fe according to claim 6 or 7
3o
4the preparation method of magnetoelectricity complex microsphere, is characterized in that: described PEG-DA, 2-hydroxy-2-methyl-1-phenyl-1-acetone, Fe
3o
4the mass ratio of nano particle and PVDF solution is 34:6:10:50.
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| CN201510113429.6A CN104689775A (en) | 2015-03-16 | 2015-03-16 | Droplet type micro-fluidic chip and method of preparing PVDF (Polyvinylidene Fluoride)-Fe 3O4 magnetic-electric composite microspheres by using the same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105513741A (en) * | 2016-01-11 | 2016-04-20 | 中国科学院化学研究所 | Magnetic nanoparticle/macromolecular Janus microparticle and preparation method and application thereof |
| CN106000485A (en) * | 2016-05-12 | 2016-10-12 | 武汉大学 | Hybrid microfluidic chip and method for preparing dish-shaped double-color microspheres by means of hybrid microfluidic chip |
| CN106589412A (en) * | 2016-11-28 | 2017-04-26 | 华南理工大学 | Preparation method for polymer microgel based on microfluidic technology |
| CN109568591A (en) * | 2019-01-14 | 2019-04-05 | 中国科学院化学研究所 | A kind of software micro-nano motor and preparation method thereof |
| CN109569454A (en) * | 2018-12-04 | 2019-04-05 | 武汉比西迪电池材料有限公司 | A kind of PVDF method for coating using dissolubility difference |
| CN110918141A (en) * | 2018-09-20 | 2020-03-27 | 北京怡天佳瑞科技有限公司 | Micro-fluidic chip, device containing micro-fluidic chip and application for preparing micro-emulsified liquid drops |
| WO2023231397A1 (en) * | 2022-05-30 | 2023-12-07 | 中国科学院深圳先进技术研究院 | Polymer microsphere preparation apparatus and method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1884514A (en) * | 2006-06-14 | 2006-12-27 | 武汉大学 | Microflow chip and method for preparing polymer microsphere using same |
| WO2007101174A2 (en) * | 2006-02-27 | 2007-09-07 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Digital magnetofluidic devices and methods |
| CN101249410A (en) * | 2008-04-10 | 2008-08-27 | 华东理工大学 | Preparation of organic-inorganic composite microballoons |
| CN103223357A (en) * | 2012-01-26 | 2013-07-31 | 三星电子株式会社 | Microfluidic device and control method thereof |
| CN103801241A (en) * | 2014-02-27 | 2014-05-21 | 东华大学 | Method for preparing developing photonic crystal microspheres by using micro-reaction device and applied magnetic field |
-
2015
- 2015-03-16 CN CN201510113429.6A patent/CN104689775A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007101174A2 (en) * | 2006-02-27 | 2007-09-07 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Digital magnetofluidic devices and methods |
| CN1884514A (en) * | 2006-06-14 | 2006-12-27 | 武汉大学 | Microflow chip and method for preparing polymer microsphere using same |
| CN101249410A (en) * | 2008-04-10 | 2008-08-27 | 华东理工大学 | Preparation of organic-inorganic composite microballoons |
| CN103223357A (en) * | 2012-01-26 | 2013-07-31 | 三星电子株式会社 | Microfluidic device and control method thereof |
| CN103801241A (en) * | 2014-02-27 | 2014-05-21 | 东华大学 | Method for preparing developing photonic crystal microspheres by using micro-reaction device and applied magnetic field |
Non-Patent Citations (1)
| Title |
|---|
| 曹渊等: "纳米无机物/高分子磁功能复合材料研究进展", 《压电与声光》, vol. 28, no. 01, 28 February 2006 (2006-02-28), pages 56 - 59 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105513741A (en) * | 2016-01-11 | 2016-04-20 | 中国科学院化学研究所 | Magnetic nanoparticle/macromolecular Janus microparticle and preparation method and application thereof |
| CN105513741B (en) * | 2016-01-11 | 2017-07-28 | 中国科学院化学研究所 | Magnetic nano-particle/macromolecule compound Janus particulate and preparation method and application |
| CN106000485A (en) * | 2016-05-12 | 2016-10-12 | 武汉大学 | Hybrid microfluidic chip and method for preparing dish-shaped double-color microspheres by means of hybrid microfluidic chip |
| CN106589412A (en) * | 2016-11-28 | 2017-04-26 | 华南理工大学 | Preparation method for polymer microgel based on microfluidic technology |
| CN106589412B (en) * | 2016-11-28 | 2018-09-14 | 华南理工大学 | A kind of preparation method of the polymer microgel based on microflow control technique |
| CN110918141A (en) * | 2018-09-20 | 2020-03-27 | 北京怡天佳瑞科技有限公司 | Micro-fluidic chip, device containing micro-fluidic chip and application for preparing micro-emulsified liquid drops |
| CN110918141B (en) * | 2018-09-20 | 2023-09-12 | 上海欣戈赛生物科技有限公司 | Microfluidic chip, device containing microfluidic chip and application for preparing micro-emulsified liquid drops |
| CN109569454A (en) * | 2018-12-04 | 2019-04-05 | 武汉比西迪电池材料有限公司 | A kind of PVDF method for coating using dissolubility difference |
| CN109568591A (en) * | 2019-01-14 | 2019-04-05 | 中国科学院化学研究所 | A kind of software micro-nano motor and preparation method thereof |
| WO2023231397A1 (en) * | 2022-05-30 | 2023-12-07 | 中国科学院深圳先进技术研究院 | Polymer microsphere preparation apparatus and method |
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