CN104644289A - Method for preparing artificial bone prosthesis with dual gaps - Google Patents
Method for preparing artificial bone prosthesis with dual gaps Download PDFInfo
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- CN104644289A CN104644289A CN201510130395.1A CN201510130395A CN104644289A CN 104644289 A CN104644289 A CN 104644289A CN 201510130395 A CN201510130395 A CN 201510130395A CN 104644289 A CN104644289 A CN 104644289A
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Abstract
The invention provides a method for preparing artificial bone prosthesis with dual gaps. The method comprises the following steps: constructing a three-dimensional model of the original skeleton by utilizing medical image data, determining a basic unit according to the three-dimensional model of the original skeleton and the size of the pre-constructed bone gaps, constructing and generating an overall unit according to the shape and size of the three-dimensional model of the original skeleton by taking the basic unit as the basis, performing Boolean operation on the three-dimensional model of the original skeleton and the overall unit to generate a three-dimensional skeleton model with bone gaps, and optimizing the three-dimensional skeleton model with bone gaps; and printing a skeleton matrix with bone gaps by utilizing a material increase manufacturing technology, and performing biological coating treatment on the skeleton matrix with the bone gaps, wherein a first coating and a second coating are sequentially attached to the skeleton matrix, and the two coatings are provided with gaps with different densities. According to the method disclosed by the invention, the biocompatibility and stability of the artificial bone prosthesis are improved, and replication, growth and repair of cells are promoted.
Description
Technical field
The present invention relates to a kind of preparation method with the artificial bone prosthese of dual void, belong to bio-medical prosthese technical field.
Background technology
The generation of vehicle accident, natural disaster, easily cause the damage of skeleton, patient disabilities can be caused time serious even to lose self care ability, help the sclerous tissues of bone injury patient's repair deficiency or disappearance, recovering human body hard tissue function is better the problem that medical circle makes great efforts to explore always.
Artificial bone prosthese, as a kind of technology solving and repair autologous skeletal injury, so far, has obtained global accreditation.But, artificial bone prosthese in actual use, still there is larger problem in its biocompatibility and reliability aspect, this is because, bone prosthese is made of metal, itself contain some toxic elements, easily rejection and uncomfortable phenomenon is there is after displacement, in prior art, by carrying out roughening process in bone prosthetic surface, or nanorize process, or carry out the biocompatibility that the methods such as hydroxyapatite coating layer process improve bone prosthese, but, single surface treatment can only improve the osteoinductive of bone prosthetic surface, the long-term repair of prosthese cannot be promoted, and, also there is coating and hold caducous problem in coating process, such as, Chinese patent CN201310122806 and CN201310122725, even if carry out biological coating process outside metal prostheses, but due to metal and coating bi-material mechanical property inconsistent, be easy to cracking and come off, thus reduce the reliability of bone prosthese.
Summary of the invention
In view of the foregoing, the object of the present invention is to provide a kind of preparation method with the artificial bone prosthese of dual void, the bone prosthese utilizing the method to prepare, not only has good biocompatibility, has good stability simultaneously.
For achieving the above object, the present invention is by the following technical solutions:
There is a preparation method for the artificial bone prosthese of dual void, comprise the following steps:
S1: utilize medical image data to construct the threedimensional model of original skeleton;
S2: according to the size determination elementary cell in original skeleton threedimensional model and pre-structured diaphysis space, builds generate integral unit according to the shape of original skeleton threedimensional model, size based on this elementary cell;
S3: by original skeleton threedimensional model and this integral unit by after Boolean calculation process, generates the skeleton threedimensional model with diaphysis space;
S4: process is optimized to the skeleton threedimensional model with diaphysis space generated;
S5: based on the skeleton threedimensional model after optimization, utilizes increasing material manufacturing technology to print the bone matrix with diaphysis space;
S6: on the bone matrix with diaphysis space, carries out biological coating process.
Further,
In described step S6, carry out biological coating process and comprise the following steps:
Described bone matrix carries out the coating process of ground floor, and bioceramic solution is entered bone prosthese by the diaphysis space on described bone matrix inner, form the first coating of bone matrix, this first coating formation has lax thick space;
Described bone matrix carries out the coating process of the second layer, and bioceramic solution is entered bone prosthese by the diaphysis space on described bone matrix inner, form the second coating of bone matrix, this second coating formation has intensive thin space.
In described step S2, determine the distribution, density degree etc. in pre-structured diaphysis space according to the concrete position of bone prosthese, clinical replacement scenario, fixing situation and relevant biomechanical knowledge.
In described step S2, described elementary cell is carried out copying, splicing on horizontal, longitudinal, generates described integral unit.
In described step S3, described original skeleton threedimensional model and integral unit are carried out registration process, then Boolean calculation is carried out, described integral unit is deducted in the scope of described original skeleton threedimensional model, have the skeleton threedimensional model in diaphysis space described in obtaining, this model presents the diaphysis space communicated completely from the inside to surface.
In described step S2, the concrete form of described elementary cell is determined according to the volume of skeleton or thin degree, and the stressing conditions of this elementary cell is consistent with its microcosmic stress form.
The form of described elementary cell can be HCP, FCC, BCC crystal habit.
In described step S4, to the described skeleton threedimensional model with diaphysis space, carry out simulation analysis and optimization, this simulation analysis comprises statics Analysis, kinematics analysis, dynamic analysis.
In described step S5, when printing described bone matrix, skeleton threedimensional model entirety is reduced certain proportion, for thickness space is reserved in follow-up biological coating process.
The invention has the advantages that:
The artificial bone prosthese prepared according to method of the present invention, there is dual void: metal bone matrix has diaphysis space, be conducive to bioceramic solution and enter intrinsic silicon through diaphysis space, improve the combination stability between matrix and coating, prevent coating shedding; Biological coating has two-layer, and two layers of coatings has the different space of density, and sparse space is conducive to the attachment of cell, growth and repairs, and the density of bone prosthetic surface can be improved in intensive space, improves wearability and intensity, improves the reliability of bone prosthese.In addition, the present invention utilizes and increases the realization of material manufacturing technology, can go out bone prosthese by printing speed, and can save material, reduce prosthese quality.
Accompanying drawing explanation
Fig. 1 is method flow schematic diagram of the present invention.
Fig. 2 is the microcosmic schematic diagram in the cross section of artificial bone prosthese of the present invention.
Fig. 3 is the microstructure schematic diagram of the elementary cell of the present invention one specific embodiment.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is further detailed explanation.
Fig. 1 is method flow schematic diagram of the present invention, and as shown in the figure, the preparation method with the artificial bone prosthese of dual void disclosed by the invention, comprises the following steps:
S1: utilize medical image data to construct the threedimensional model of original skeleton;
On the basis of skeleton MRI or CT data, successively extract the outline (Mimics software can be utilized to extract) of skeleton, then generate the threedimensional model of original skeleton according to the outline overall fit of every one deck.
S2: according to the threedimensional model of original skeleton and the size determination elementary cell in pre-structured diaphysis space, builds according to the shape of original skeleton threedimensional model, size and generates integral unit based on elementary cell;
First, a kind of elementary cell of form is determined according to the threedimensional model of original skeleton and the size in pre-structured diaphysis space, and the distribution, density degree etc. in pre-structured diaphysis space is determined according to the position of bone prosthese, clinical replacement scenario, fixing situation and relevant biomechanical knowledge, as, the bone prosthese (as long bone) of large volume, the diaphysis space of structure should more greatly, thinner prosthese (as phalanges), and the diaphysis space of structure should be more intensive; The fixed position of bone prosthese and marginal portion not easily distributed voids, in order to avoid affect intensity;
Then, according to shape, the size of original skeleton threedimensional model, elementary cell is carried out copying, splicing on horizontal, longitudinal, generates the integral unit substantially adapted with original skeleton threedimensional model shape, size;
Fig. 3 is the microstructure schematic diagram of the elementary cell of the present invention one specific embodiment, and as shown in the figure, elementary cell 6 generates lateral cell 7 after laterally copying, splicing, and lateral cell 7 generates integral unit 8 again after longitudinally copying, splicing; Copying wherein, splicing refer to, what arrange elementary cell copies number and displacement, realizes the modeling of multiple base unit, and ensure the communicating of diaphysis space, unanimously, are beneficial to the reparation of cell after the making of follow-up coating and displacement.
The concrete form of elementary cell can design according to the volume of skeleton or thin degree, and as far as possible design principle makes its stressing conditions consistent with microcosmic stress form, and the form of elementary cell can with reference to common crystal structure, as HCP, FCC, BCC etc.
S3: by original skeleton threedimensional model and integral unit by after Boolean calculation process, generates the skeleton threedimensional model with diaphysis space;
Original skeleton threedimensional model and integral unit are carried out registration process, then Boolean calculation is carried out, in the scope of original skeleton threedimensional model, deduct integral unit, obtain the skeleton threedimensional model with diaphysis space, this model presents the diaphysis space communicated completely from the inside to surface.
S4: process is optimized to the skeleton threedimensional model with diaphysis space generated;
To the skeleton threedimensional model with diaphysis space, carry out simulation analysis and optimization, specifically,
According to biomechanical knowledge, the software (as ABAQUS software) that can realize statics simulation analysis is utilized to carry out statics Analysis, to ensure artificial bone borrowed structure reliability in a static condition; Then, utilization can realize the software (as ADAMS software) of Dynamics Simulation Analysis, set up other skeleton models matched with artificial bone prosthese, and carry out Kinematics Simulation to guarantee the reliability and stability of artificial bone prosthese under moving condition based on the relevant knowledge in body biomechanics and rehabilitation engineering; Finally, utilize MATLAB software to carry out dynamics simulation, determine the motion of artificial bone prosthese and stressed reasonability further.In above-mentioned each simulation process, according to simulation result, reasonability amendment is carried out to skeleton threedimensional model, then again emulate, until simulation result is good.
S5: based on the skeleton threedimensional model after optimization, utilizes increasing material manufacturing technology to print the bone matrix with diaphysis space;
The threedimensional model of skeleton is converted to stl file form, this stl file is inputed to and increases material manufacturing equipment, to print the bone matrix of titanium alloy material; Consider that subsequent metal bone prosthese also will carry out biological coating process, when printing bone matrix, model entirety is reduced certain proportion, makes the bone prosthese after the process of subsequent bio coating suitable with green bone size.
S6: on the bone matrix with diaphysis space, carries out biological coating process.
On the basis of bone matrix with diaphysis space, the bioceramic comprising the compositions such as hydroxyapatite is melted for solution, under the effect of chemical reaction, it is inner that bioceramic solution enters bone prosthese by the diaphysis space on bone matrix, and be attached on bone matrix, the binding ability of coating and matrix can be improved, prevent from coming off.
For ensureing that bone prosthese has good biocompatibility and wearability, and guarantee biological coating difficult drop-off and have good stability, the present invention, when carrying out biological coating process, is divided into following two steps:
Bone matrix carries out the coating process of ground floor, namely, chemical reaction is utilized to make bioceramic solution enter bone prosthese by the diaphysis space on bone matrix inner, form the first coating of bone matrix, in the forming process of the first coating, by the control to temperature or electric current, the first coating is made to generate comparatively lax thick space, to improve the binding ability of bone matrix and coating, be conducive to the attachment of cell after Using prosthesis, growth and reparation;
Bone matrix carries out the coating process of the second layer, namely, on the bone matrix basis of above-mentioned attachment first coating, chemical reaction is utilized to make bioceramic solution enter bone prosthese by the diaphysis space on bone matrix inner, form the second coating of bone matrix, in the forming process of the second coating, by the control to temperature or electric current, the second coating is made to generate comparatively intensive thin space, to improve the density of bone prosthetic surface, improve wearability and intensity, increase the reliability of bone prosthese.
As shown in Figure 2, it is the microstructure schematic diagram in the cross section of complying with the bone prosthese that method of the present invention is made, and has the artificial bone prosthese of dual void, comprises bone matrix 5, is attached to first coating 1 and second coating 2 on bone matrix surface successively; Bone matrix 5 has diaphysis space 4, be conducive to entering and attachment of two layers of coatings, first coating 1 has sparse thick space, namely the spacing between each molecule 3 is larger, and the second coating 2 has intensive thin space, each intermolecular spacing is less, and from large to small from inside to outside, the microstructure of this and skeleton is very similar in the space of whole bone prosthese.
The preparation method with the artificial bone prosthese of dual void of the present invention, first build original skeleton threedimensional model, according to the size determination elementary cell in pre-structured diaphysis space, based on elementary cell, integral unit is constructed according to the size of original skeleton threedimensional model, shape, integral unit is deducted in original skeleton threedimensional model, generate the skeleton threedimensional model with diaphysis space, after model optimization process, utilize increasing material manufacturing technology to print the bone matrix with diaphysis space, this bone matrix adheres to the first coating and the second coating successively.Bone matrix has diaphysis space, is conducive to guiding bioceramic solution to enter intrinsic silicon through diaphysis space, reduces " stress shielding " between bone matrix and biological coating, improves combination stability therebetween, prevent coating shedding; First, second coating has the different space of density, by the control to temperature or electric current, the thick space that first coating formation has spacing larger, can improve the binding ability of bone matrix and coating, be conducive to the attachment of cell after bone Using prosthesis, growth and reparation, the second coating is attached in the first coating, it is formed with the less thin space of spacing, the density of bone prosthetic surface can be improved, improve wearability and intensity, improve the reliability of bone prosthese.
The present invention utilizes the diaphysis space of bone matrix and the gap structure of two layers of coatings, improve biocompatibility and the stability of artificial bone prosthese, after displacement bone prosthese, by cell long-term repair, engulf and realize osteanagenesis, make bone prosthese gradate as real skeleton becomes possibility; In addition, the present invention utilizes and increases material manufacturing technology, can realize the printing speed of fine structure titanium prosthesis, alleviate prosthese quality, saves material.
The above know-why being preferred embodiment of the present invention and using; for a person skilled in the art; when not deviating from the spirit and scope of the present invention; any based on apparent changes such as the equivalent transformation on technical solution of the present invention basis, simple replacements, all belong within scope.
Claims (9)
1. there is the preparation method of the artificial bone prosthese of dual void, it is characterized in that, comprise the following steps:
S1: utilize medical image data to construct the threedimensional model of original skeleton;
S2: according to the size determination elementary cell in original skeleton threedimensional model and pre-structured diaphysis space, builds generate integral unit according to the shape of original skeleton threedimensional model, size based on this elementary cell;
S3: by original skeleton threedimensional model and this integral unit by after Boolean calculation process, generates the skeleton threedimensional model with diaphysis space;
S4: process is optimized to the skeleton threedimensional model with diaphysis space generated;
S5: based on the skeleton threedimensional model after optimization, utilizes increasing material manufacturing technology to print the bone matrix with diaphysis space;
S6: on the bone matrix with diaphysis space, carries out biological coating process.
2. there is the preparation method of the artificial bone prosthese of dual void as claimed in claim 1, it is characterized in that, in described step S6, carry out biological coating process and comprise the following steps:
Described bone matrix carries out the coating process of ground floor, and bioceramic solution is entered bone prosthese by the diaphysis space on described bone matrix inner, form the first coating of bone matrix, this first coating formation has lax thick space;
Described bone matrix carries out the coating process of the second layer, and bioceramic solution is entered bone prosthese by the diaphysis space on described bone matrix inner, form the second coating of bone matrix, this second coating formation has intensive thin space.
3. there is the preparation method of the artificial bone prosthese of dual void as claimed in claim 1 or 2, it is characterized in that, in described step S2, determine the distribution, density degree etc. in pre-structured diaphysis space according to the concrete position of bone prosthese, clinical replacement scenario, fixing situation and relevant biomechanical knowledge.
4. there is the preparation method of the artificial bone prosthese of dual void as claimed in claim 3, it is characterized in that, in described step S2, described elementary cell is carried out copying, splicing on horizontal, longitudinal, generates described integral unit.
5. there is the preparation method of the artificial bone prosthese of dual void as claimed in claim 4, it is characterized in that, in described step S3, described original skeleton threedimensional model and integral unit are carried out registration process, then Boolean calculation is carried out, in the scope of described original skeleton threedimensional model, deduct described integral unit, have the skeleton threedimensional model in diaphysis space described in obtaining, this model presents the diaphysis space communicated completely from the inside to surface.
6. there is the preparation method of the artificial bone prosthese of dual void as claimed in claim 1, it is characterized in that, in described step S2, the concrete form of described elementary cell is determined according to the volume of skeleton or thin degree, and the stressing conditions of this elementary cell is consistent with its microcosmic stress form.
7. have the preparation method of the artificial bone prosthese of dual void as claimed in claim 6, it is characterized in that, the form of described elementary cell can be HCP, FCC, BCC crystal habit.
8. there is the preparation method of the artificial bone prosthese of dual void as claimed in claim 1, it is characterized in that, in described step S4, to the described skeleton threedimensional model with diaphysis space, carry out simulation analysis and optimization, this simulation analysis comprises statics Analysis, kinematics analysis, dynamic analysis.
9. there is the preparation method of the artificial bone prosthese of dual void as claimed in claim 1, it is characterized in that, in described step S5, when printing described bone matrix, skeleton threedimensional model entirety is reduced certain proportion, for thickness space is reserved in follow-up biological coating process.
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| CN112704582A (en) * | 2021-01-25 | 2021-04-27 | 山东建筑大学 | Preparation method of customizable regenerated porous nano-material 3D printed femoral head |
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| CN112704582A (en) * | 2021-01-25 | 2021-04-27 | 山东建筑大学 | Preparation method of customizable regenerated porous nano-material 3D printed femoral head |
| CN115414159A (en) * | 2022-09-19 | 2022-12-02 | 中国人民解放军联勤保障部队第九二〇医院 | Artificial scaphoid prosthesis and preparation method and preparation tool thereof |
| CN116029161A (en) * | 2023-03-27 | 2023-04-28 | 北京爱康宜诚医疗器材有限公司 | Prosthesis design method with gradual porosity |
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