CN104367478A - Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation - Google Patents
Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation Download PDFInfo
- Publication number
- CN104367478A CN104367478A CN201410657383.XA CN201410657383A CN104367478A CN 104367478 A CN104367478 A CN 104367478A CN 201410657383 A CN201410657383 A CN 201410657383A CN 104367478 A CN104367478 A CN 104367478A
- Authority
- CN
- China
- Prior art keywords
- tablets
- mixing granulation
- granulator
- tablet
- granulation equipment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses granulating equipment. The granulating equipment comprises a pressure tank and a mixed granulating machine, the pressure tank is arranged on the left side of the mixed granulating machine, the upper portion of the pressure tank is provided with a compressed air connector, the bottom of the pressure tank is provided with a connection hose, and the connection hose is used for being connected with the pressure tank and the mixed granulating machine. The granulating equipment further comprises a sprinkler, the top of the sprinkler is provided with holes, and the sprinkler is arranged on the upper half portion of the mixed granulating machine and is connected with the connection hose through a connection pipe. The granulating equipment is suitable for preparing solid preparations like capecitabine tablets, moxifloxacin hydrochloride tablets, Letrozol tablets, anastrozole tablets, repaglinide tablets, acarbose chewable tablets and tacrolimus capsules. The granulating equipment is easy and convenient to operate; the prepared particles are good in mobility and compressibility; the manufactured preparations are smooth and attractive in appearance and free of spots on surfaces, meanwhile, the quality indexes like disintegration time, the dissolution rate and the content uniformity all accord with or exceed inner quality standards, and finally the solid preparations with good quality can be obtained.
Description
Technical field
The present invention relates to a kind of facility for granulating, particularly a kind of mixing granulation equipment and preparing the purposes in solid preparation.
Background technology
Mixing granulation is a kind of method of granulating the most frequently used during solid preparation is produced.During granulation, the feed postition of material used is directly added by thicker pipeline substantially, or adopts spray gun.
In prior art, material feed postition has following defect:
1, extra heavy pipe formula adds material, easily be gathered in powder place, not easily disperse, thus Granulation time can be extended, and particle properties can be affected, if add material comparatively thickness, using extra heavy pipe formula to add then can appreciable impact particle properties, cause granule agglomerating, affect the product content uniformity, dissolution, even cannot carry out subsequent process steps.
2, torch-type adds is that liquid dispels by pneumatically, but material amounts is more or comparatively thickness time, not easily to add and required time is long, cause the particle size distribution that obtains undesirable, and granule is comparatively hard, and the joining day is oversize, former, adjuvant impurity increase may be caused, impact sheeting process below, has a strong impact on the outward appearance of tablet, disintegrate and dissolution, and torch-type feed postition is relatively applicable to the preparation of joining day without particular/special requirement.
In existing facility for granulating, the spray gun of atomization feed liquid only arranges one, and this makes the viscosity of feed liquid and inventory be restricted, and its production cycle is long, and energy consumption is high, and production cost is high, and production efficiency is low, cannot meet the actual demand of production.
3, during industrialized great production, required inventory of sometimes once granulating reaches 20-30kg, if material used is starch slurry, temperature reaches more than 90 DEG C, if lift starch slurry in the hopper of the top of granulator, easily causes the scald of operator.
4, when material adds pressurized tank in currently available technology, easily assemble, cause Granulation time long, thus affect granule physicochemical property, partial material adopts prior art to add in hopper, easily causes the shortcomings such as the scald of operator.
Chinese invention patent CN200410098569.2; disclose a kind of fluidization and spray-drying pelleting machine; multiple spray gun is provided with in the junction of spray drying chamber and boiling granulating room; accelerate granulation speed, reduce cost, improve the homogeneity of seed powder with the bonding of atomization feed liquid; but the impact of this equipment on the disintegration time of preparation and dissolution is not open; and this equipment is also not suitable for the large feed liquid of viscosity adding as starch slurry, this device structure is complicated in addition, and cost is high.
Chinese invention patent CN02138130.5, disclose a kind of high Viscosity material drying and powder making equipment, be used for preparing the equipment of high viscosity high-moisture gluten meal gluten, adopt its top feed, viscous material is vertically entered in granulation device by orifice plate, is namely become fine particle by blade cuts, and this device structure is complicated, cost is high, is applicable to block high viscosity powder process.
Therefore, this area need find that a kind of granulation speed is fast, simple to operate, cheap, safety coefficient is high, and obtained granule loosely, the mixing granulation equipment that is greatly improved of disintegration of tablet, dissolution, content uniformity.
Summary of the invention
The object of this invention is to provide a kind of mixing granulation equipment, there is the problems such as potential safety hazard to solve in prior art, the degree of scatter more solving the viscous material of existence is low, causes Granulation time oversize, the technological deficiency such as the granule physicochemical property of preparation is not good enough.
In order to solve the problems of the technologies described above, the present invention is solved by following technical proposals:
A kind of mixing granulation equipment; comprise pressurized tank and mixer-granulator; described pressurized tank is placed in the left side of mixer-granulator; compressed air interface is equipped with on top, and connecting hose is equipped with in bottom, and described connecting hose is used for Bonding pressure tank and mixer-granulator; also comprise a gondola water faucet; described gondola water faucet top is porose, is placed in the middle and upper part of mixer-granulator, is connected by connecting pipe with connecting hose.
As preferably, described connecting pipe is connected by clamp flange with connecting hose.
As preferably, described gondola water faucet is the column of a hollow, is threaded connection part is connected with connecting pipe.
As preferably, described pressurized tank is connected by clip two-way control valve with connecting hose.
As preferably, described hole is round and/or square, the rounded top being distributed in gondola water faucet.
As preferably, described hole is 5-100, and more preferably 20-80, aperture is 0.5-5.0mm, more preferably 1-3mm.The number in described hole and the size in aperture select suitable specification according to the size of granulator.
By gondola water faucet add mixer-granulator for viscous material.Described viscous material is 25 DEG C time, and adopt " Chinese Pharmacopoeia " version in 2010 two Ping Shi viscosimeters to measure, viscosity number is 2.5-2000mpa.s.
As preferably, described viscous material is polyvinylpyrrolidonesolution solution, microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose, hypromellose cellulose solution, hydroxypropyl cellulose alcoholic solution, ethyl cellulose solution, pregelatinized Starch.
Viscosity is less than the material of 2.5mpa.s as water and ethanol in addition, also can adopt granulator of the present invention.Utilize product prepared by present device, its physicochemical property such as disintegration time and dissolution also all can meet the prescription of medicine.
Viscosity of the present invention is the abbreviation of dynamic viscosity, the viscosity of room temperature water is 1mPas, the accompanying drawing 1 in " Chinese Pharmacopoeia " version in 2010 two annex VI G is shown in by the present invention's Ping Shi viscosimeter used, viscosity measurement is shown in " Chinese Pharmacopoeia " version in 2010 two first methods: measure dynamic viscosity or dynamic viscosity with Ping Shi viscosimeter.
In addition, present invention also offers a kind of mixing granulation equipment and prepare solid preparation as the application in Tablet and Capsula.When preparing tablet or capsule, according to active matter qualitative attribution, the liquid viscosity of sometimes selected adjuvant made by before granulation is larger, successfully feed liquid cannot be sprayed with the spray gun of routine, thus make Granulation time long, affect particle properties, cause product dissolution etc. defective.When preparation; as long as selected pharmaceutical adjunct is viscous material; all available granulator disclosed in this invention is granulated; and be specially adapted to the medicament needing to select the larger material of viscosity as adjuvant, such as hundred make sheet, capecitabine sheet, letrozole sheet, anastrozole tablets, repaglinide, methylsulfonic acid imatinib tablet, Acarbose chewable tablet, moxifloxacin chloride tablets, clarithromycin tablet, Rates of Pioglitazone Hydrochloride Tablets Preparation, mycophenolate mofetil dispersible tablet and tacrolimus slow release capsule etc.
Compared with prior art, the Advantageous Effects that brings of the present invention is as follows:
(1) structure of the present invention is simple, automaticity is high, simple to operate, under the prerequisite not introducing high cost import granulator, compensate for dispersion when adopting extra heavy pipe formula to add viscous material not good enough, or adopt torch-type to add and cause granule defect really up to the mark and that cause impurity to increase because drying time is long because Granulation time is long, employing spraying head type adds, degree of scatter can be met high simultaneously, the demand that Granulation time is short, and uniform particles can be prepared smoothly, and particle size distribution is reasonable, the formulation disintegrates obtained, dissolution, the quality index such as content uniformity all meet inner quality standard, and had and increase substantially.
(2) the present invention improves on existing equipment basis, sets up pressure pot equipment, instead of original spray gun or extra heavy pipe with gondola water faucet, by improving, reach unexpected effect, with low cost, be applicable to very much the more difficult middle-size and small-size pharmaceutical and chemical enterprises of domestic purchase import equipment.
(3) of the present invention widely applicable, be applicable to all products needing wet granulation.Both may be used for various Western medicine kind, also can be used for herbal species.
(4) very safe during industrialized great production of the present invention, eliminate the potential safety hazard of operator.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
The toponym that in Fig. 1, each number designation refers to is as follows: wherein 1-compressed air interface, 2-pressurized tank, 3-connecting hose, 4-connecting pipe, 5-gondola water faucet, 6-clip two-way control valve, 7-clamp flange, 8-mixer-granulator, 9-hole.
Fig. 2 is the partial enlarged drawing of Fig. 1 gondola water faucet.
The toponym that in Fig. 2, each number designation refers to is as follows: 9-hole.
Fig. 3 is the comparison diagram that extra heavy pipe formula and spraying head type add with or without mottle.
Detailed description of the invention
Below in conjunction with accompanying drawing 1 and Fig. 2 and embodiment, the present invention is described in further detail:
Embodiment 1: the preparation of capecitabine sheet
A kind of mixing granulation equipment, as depicted in figs. 1 and 2, comprises pressurized tank 2 and mixer-granulator 8, described pressurized tank 2 is placed in the left side of mixer-granulator 8, compressed air interface 1 is equipped with on top, and connecting hose 3 is equipped with in bottom, and described connecting hose 3 is for Bonding pressure tank 2 and mixer-granulator 8; Also comprise a gondola water faucet 5; be placed in the middle and upper part of mixer-granulator 8, be connected by connecting pipe 4 with connecting hose 3, described gondola water faucet 5 is the cylinder of a hollow; top has in round hole 9; the rounded top being distributed in gondola water faucet 5, described hole 9 has 50, and aperture is 2mm; with being threaded between described gondola water faucet 5 and connecting pipe 4; connecting pipe 4 is connected by clamp flange with connecting hose 3, and pressurized tank 2 is connected by clip two-way control valve with connecting hose 3, for convenience detach.
The production technology of capecitabine sheet is as follows: 4.00Kg capecitabine, 0.42Kg lactose, 0.20Kg cross-linking sodium carboxymethyl cellulose and 0.42Kg microcrystalline Cellulose are joined in HLSG20A type mixer-granulator 8; open mixing speed 160rpm; chopping speed 1300rpm, mix homogeneously.The hydroxypropyl emthylcellulose aqueous solution adopting gondola water faucet 5 to add 5% carries out wet granulation in mixer-granulator, then dry, granulate; Add appropriate magnesium stearate mix homogeneously, tabletting, coating and get final product.
During work; 5% hydroxypropyl emthylcellulose aqueous solution is joined in pressurized tank 2; compressed air valve aperture is regulated to make the pressure in pressurized tank 2 be 1.3kg; then by compressed air, 5% hypromellose aqueous solution in pressurized tank 2 is arrived gondola water faucet 5 by connecting hose 3 is rear, then by the hole 9 on gondola water faucet 5 and the unclassified stores dispersion and granulation in HLSG20 type mixer-granulator.
By the made uniform particles of above method, and particle size distribution is reasonable, and the quality index such as disintegration of tablet time limit, dissolution, content uniformity be pressed into all meets inner quality standard, and has had and increase substantially.Concrete relatively in table 1 and table 2.
Table 1: the capecitabine sheet prepared according to embodiment 1, the capecitabine sheet stripping curve measurement result that different binding agent feed postition is obtained compares (n=6; Dissolution medium: water)
From accumulation stripping result, with commercially available product (xeloda) for reference preparation, get 10min, 15min, 20min and 30min totally 4 groups of data in table 1, calculate dissolution F2 factor values respectively, it is 43.59 that extra heavy pipe formula adds fashionable F2 value; It is 53.64 that torch-type adds fashionable F2 value; It is 78.49 that spraying head type adds fashionable F2 value;
Stripping curve similar factors F2 value is less than 50, does not meet the quality conformance of imitation medicine.Know from table 1, extra heavy pipe formula adds and does not meet imitated prescription, although torch-type adds meet imitated prescription, the consistent behavior of In Vitro Dissolution is effective not as spraying head type.To sum up, spraying head type adds and adds the dissolved corrosion of obtained tablet and the more similar of commercially available product than other modes.
The comparison of other quality index of capecitabine sheet that the different feed postition of table 2 binding agent obtains:
Know from table 2, adopt spraying head type to add binding agent and carry out wet granulation, the disintegration time of final obtained capecitabine sheet is short, and content uniformity is good and granule is more loose, and granule compressibility is better.
Embodiment 2: the preparation of moxifloxacin chloride tablets
The connected mode of the mixing granulation equipment of embodiment 2 is identical with embodiment 1, and difference is:
Rounded hole 9 is arranged at described gondola water faucet 5 top, is roundedly distributed in gondola water faucet 5 top, and described hole 9 has 70, and aperture is 1.0mm.
The production technology of moxifloxacin chloride tablets is as follows: join in HLSG20A type mixer-granulator by 3.4kg moxifloxacin hydrochloride, 0.9kg pregelatinized Starch, 0.6kg microcrystalline Cellulose, 0.15kg cross-linking sodium carboxymethyl cellulose; open mixing speed 150rpm; chopping speed 1300rpm, mix homogeneously.Do wetting agent with water and carry out wet granulation, then dry, granulate; Add appropriate magnesium stearate mix homogeneously, tabletting, coating and get final product.
During work; water is joined in pressurized tank 2; compressed air valve aperture is regulated to make the pressure in pressurized tank be 1.2kg; by compressed air, the water in pressurized tank 2 is arrived gondola water faucet 5 by connecting hose 3 is rear, then granulated with the material dispersion in HLSG20A type mixing mixer-granulator 8 by the hole 9 on gondola water faucet.
The grain color prepared by above method is even, and particle size distribution is reasonable, and the quality index such as the content uniformity of granule, tabletting situation and disintegration of tablet time limit all meet inner quality standard, and has had and increase substantially.
Concrete outcome is in table 3.
Table 3: the moxifloxacin chloride tablets prepared according to embodiment 2, the comparison of the different feed postition of wetting agent
| Technique/quality index | Extra heavy pipe formula adds | Torch-type adds | Spraying head type adds |
| Granule content homogeneity (RSD) | 1.8％ | 1.7％ | 1.8％ |
| Mobility of particle | Well | Difference | Well |
| Tablet appearance | Fineness is poor | Can not normal tabletting | Well |
| Disintegration time (min) | 3 | / | 3 |
Know from table 3, the content uniformity of three kinds of made granules of feed postition without significant difference, but mobility of particle and tabletting situation different; It is identical that extra heavy pipe formula adds the disintegration time added with spraying head type.Though it is good that extra heavy pipe formula adds made mobility of particle, tablet appearance is not good enough; It is too thin that torch-type adds made granule, poor fluidity, cannot normal tabletting; Spraying head type is only had to add made granule no matter mobility or tabletting situation, all well.Thus illustrate that spraying head type adds and has obvious advantage.
Embodiment 3: hundred makes the preparation of sheet
The connected mode of the mixing granulation equipment of embodiment 3 is identical with embodiment 1, and difference is:
The hole 9 be square is arranged at described gondola water faucet 5 top, is roundedly distributed in gondola water faucet 5 top, and described hole 9 has 80, and aperture is 1.5mm.
Hundred make the production technology of sheet as follows: it is in SHK-220A type mixer-granulator that the Cordyceps fungus powder that fermented by 30kg, 5kg pregelatinized Starch, 4kg microcrystalline Cellulose join model, open and stir " I " shelves, chopping " I " shelves, mix homogeneously.Do binding agent with 10% hydroxypropyl cellulose alcoholic solution and carry out wet granulation, then dry, granulate; Add appropriate magnesium stearate mix homogeneously, tabletting and get final product.
During work; 10% hydroxypropyl cellulose alcoholic solution is joined in pressurized tank 2; compressed air valve aperture is regulated to make the pressure in pressurized tank 2 be 2.0kg; by compressed air, 10% hydroxypropyl cellulose alcoholic solution in pressurized tank 2 is arrived gondola water faucet 5 by connecting hose 3 is rear, then granulated with the material dispersion in SHK-220A type mixer-granulator by the hole 9 on gondola water faucet 5.
The grain color prepared by above method is even, and particle size distribution is reasonable, and the quality index such as disintegration of tablet time limit, Color uniformity, content uniformity be pressed into all meets inner quality standard, and has had and increase substantially.
Concrete outcome is in table 4.Comparison diagram with or without mottle is shown in Fig. 3.
Table 4: prepare according to embodiment 3 hundred make sheet, the comparison of different binding agent feed postition
Hundred make the active ingredient of sheet be fermented cordyceps sinensis mycelia, that the phorozoon-China pilose spore (Classification system is Hirsutella sinensis) of Chinese Cordyceps fungus (Classification system is Cordyceps sinensis) adopts industrial fermentation to produce to obtain, identical with the Caps Bailing content of production and sales with Zhongmei Huadong Pharmaceutical Co., Ltd. Hangzhou.Fermented cordyceps sinensis mycelia character is loosened, and color is brown color, and fibrous material is more; And other adjuvants are off-white color or faint yellow substantially, are therefore easy in tableting processes occur mottle, do not reach basic pharmaceutical requirements.And after adopting this technique, effectively improve the problem that mottle appears in tabletting.
From table 4, know, from the outward appearance aspect of most basic demand, to only have the tablet adopting gondola water faucet addition method to produce there is no mottle; Improve the mobility of granule, improve plain sheet hardness, shorten disintegration time, content uniformity aspect also has certain advantage simultaneously, thus illustrates that gondola water faucet feed postition has obvious advantage.
Embodiment 4: prepared by tacrolimus slow release capsule
The connected mode of the mixing granulation equipment of embodiment 4 is identical with embodiment 1, and difference is:
Described hole 9 has 20, and aperture is 3mm.
The production technology of tacrolimus slow release capsule is as follows: first add in pressurized tank 2 by 6.0g ethyl cellulose, dehydrated alcohol, allow ethyl cellulose swelling dissolving in dehydrated alcohol, then 20g tacrolimus is also joined in the solution of pressurized tank 2, be dissolved to clear and bright, as the binder solution containing tacrolimus.By adding lactose in 80g, to join model be in ZL300 wet mixing pelletizer 8, adds above solution and granulate, then dry, granulate; Lactose additional with 3.0Kg, 0.3Kg hypromellose, 0.02Kg magnesium stearate are mixed homogeneously again, fill and get final product.
During work; binder solution containing tacrolimus is joined in pressurized tank 2; compressed air valve aperture is regulated to make the pressure in pressurized tank be 2.0kg; by compressed air by the mixed solution in pressurized tank by arriving gondola water faucet 5 after connecting hose 3, then be that material dispersion in ZL300 wet mixing pelletizer is granulated by the hole 9 on gondola water faucet 5 and model.
By the uniform particles that above method is made, and particle size distribution is reasonable, and the quality index such as content uniformity, dissolution all meets inner quality standard, and has had and increase substantially.Concrete outcome is in table 5.
Table 5: the comparison of the different feed postition of binding agent
| Extra heavy pipe formula adds | Torch-type adds | Spraying head type adds | |
| Grain graininess | Larger | Moderate | Less |
| Content uniformity | ±12％ | ±9％ | ±5％ |
The terminal stripping that extra heavy pipe formula adds is not up to standard, and torch-type adds prominent releasing and exceeds standard, and the mode dissolution rate only having gondola water faucet to add is suitable.So as can be seen from the above, spraying head type adds most suitable.
In addition; hole of the present invention number and the size in aperture according to the difference of inventory when granulating, select the granulator of appropriate size, the number of particular hole and pore size, hole to be 5-100; aperture is that any suitable combination of 0.5-5.0mm all meets the present invention, and specific embodiment repeats no more.
The present invention is applicable to the product of all wet granulations as tablet such as letrozole sheet, anastrozole tablets, repaglinide, methylsulfonic acid imatinib tablet, Acarbose chewable tablet, moxifloxacin chloride tablets, clarithromycin tablet, Rates of Pioglitazone Hydrochloride Tablets Preparation, mycophenolate mofetil dispersible tablet and ordinary tablets, also be applied to the chemical medicine kind of other slow releasing preparation except tacrolimus slow release capsule simultaneously, be also applied in addition except hundred make sheet except other herbal species.
The explanation of above embodiment just understands method of the present invention and core concept thereof for helping.It should be pointed out that for the person of ordinary skill of the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.
Claims (10)
1. a mixing granulation equipment, comprise pressurized tank (2) and mixer-granulator (8), it is characterized in that, described pressurized tank (2) is placed in the left side of mixer-granulator (8), compressed air interface (1) is equipped with on top, connecting hose (3) is equipped with in bottom, and described connecting hose (3) is for Bonding pressure tank (2) and mixer-granulator (8); Also comprise a gondola water faucet (5), described gondola water faucet (5) top porose (9), are placed in the middle and upper part of mixer-granulator (8), are connected with connecting hose (3) by connecting pipe (4).
2. mixing granulation equipment as claimed in claim 1, it is characterized in that, described connecting pipe (4) is connected by clamp flange (7) with connecting hose (3).
3. mixing granulation equipment as claimed in claim 1, it is characterized in that, described gondola water faucet (5) is the column of a hollow, is threaded connection part is connected with connecting pipe (4).
4. mixing granulation equipment as claimed in claim 1, it is characterized in that, described pressurized tank (2) is connected by clip two-way control valve (6) with connecting hose (3).
5. mixing granulation equipment as claimed in claim 1, is characterized in that, described hole (9) for round and/or square, the rounded top being distributed in gondola water faucet (5).
6. mixing granulation equipment as claimed in claim 5, is characterized in that, described hole (9) are 5-100, and preferred 20-50, aperture is 0.5-5.0mm, preferred 1-3mm.
7. the mixing granulation equipment according to any one of claim 1-6; it is characterized in that; by gondola water faucet (5) add mixer-granulator for viscous material; described viscous material is 25 DEG C time; adopt " Chinese Pharmacopoeia " version in 2010 two Ping Shi viscosimeters to measure, viscosity number is 2.5-2000mpa.s.
8. mixing granulation equipment as described in claim 7, it is characterized in that, described viscous material is polyvinylpyrrolidonesolution solution, microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose, hypromellose cellulose solution, hydroxypropyl cellulose alcoholic solution, ethyl cellulose solution, pregelatinized Starch.
9. the mixing granulation equipment according to any one of claim 1 to 8 is preparing the application in solid preparation, preferred tablet and capsule.
10. apply as claimed in claim 9, it is characterized in that, described tablet is letrozole sheet, anastrozole tablets, capecitabine sheet, repaglinide, methylsulfonic acid imatinib tablet, Acarbose chewable tablet, moxifloxacin chloride tablets, clarithromycin tablet, Rates of Pioglitazone Hydrochloride Tablets Preparation, mycophenolate mofetil dispersible tablet, and hundred make sheet; Described capsule is tacrolimus capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410657383.XA CN104367478A (en) | 2014-11-18 | 2014-11-18 | Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410657383.XA CN104367478A (en) | 2014-11-18 | 2014-11-18 | Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104367478A true CN104367478A (en) | 2015-02-25 |
Family
ID=52546845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410657383.XA Pending CN104367478A (en) | 2014-11-18 | 2014-11-18 | Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104367478A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110575442A (en) * | 2019-10-16 | 2019-12-17 | 青海珠峰冬虫夏草药业有限公司 | Fermented cordyceps sinensis powder tablet |
| CN112552885A (en) * | 2020-12-20 | 2021-03-26 | 西南石油大学 | Superhigh temperature resistant 180 ℃ tackifying type well completion fluid and workover fluid |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54138117A (en) * | 1978-04-17 | 1979-10-26 | Takeda Chem Ind Ltd | Device for preparation of liquid starch paste |
| WO2006003504A1 (en) * | 2004-07-01 | 2006-01-12 | Warner-Lambert Company Llc | Preparation of pharmaceutical compositions containing nanoparticles |
| US20080148594A1 (en) * | 2006-12-22 | 2008-06-26 | Collette Nv | Continuous granulating and drying apparatus |
| CN102755254A (en) * | 2012-08-04 | 2012-10-31 | 安徽环球药业股份有限公司 | Granulator liquid adding structure for medicine preparation |
| CN202568883U (en) * | 2012-03-15 | 2012-12-05 | 常州市金陵干燥设备有限公司 | Multifunctional pelletization coating machine |
| CN202724265U (en) * | 2012-11-07 | 2013-02-13 | 广东和平君乐药业有限公司 | One-step granulator |
| CN203417336U (en) * | 2013-08-06 | 2014-02-05 | 天津太平洋制药有限公司 | Sugarcoating machine |
-
2014
- 2014-11-18 CN CN201410657383.XA patent/CN104367478A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54138117A (en) * | 1978-04-17 | 1979-10-26 | Takeda Chem Ind Ltd | Device for preparation of liquid starch paste |
| WO2006003504A1 (en) * | 2004-07-01 | 2006-01-12 | Warner-Lambert Company Llc | Preparation of pharmaceutical compositions containing nanoparticles |
| US20080148594A1 (en) * | 2006-12-22 | 2008-06-26 | Collette Nv | Continuous granulating and drying apparatus |
| CN202568883U (en) * | 2012-03-15 | 2012-12-05 | 常州市金陵干燥设备有限公司 | Multifunctional pelletization coating machine |
| CN102755254A (en) * | 2012-08-04 | 2012-10-31 | 安徽环球药业股份有限公司 | Granulator liquid adding structure for medicine preparation |
| CN202724265U (en) * | 2012-11-07 | 2013-02-13 | 广东和平君乐药业有限公司 | One-step granulator |
| CN203417336U (en) * | 2013-08-06 | 2014-02-05 | 天津太平洋制药有限公司 | Sugarcoating machine |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110575442A (en) * | 2019-10-16 | 2019-12-17 | 青海珠峰冬虫夏草药业有限公司 | Fermented cordyceps sinensis powder tablet |
| CN112552885A (en) * | 2020-12-20 | 2021-03-26 | 西南石油大学 | Superhigh temperature resistant 180 ℃ tackifying type well completion fluid and workover fluid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104288154A (en) | Favipiravir pharmaceutical composition containing different particle size ranges | |
| CN104367478A (en) | Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation | |
| CN102525966B (en) | A kind of tablet containing paroxetine and preparation method thereof | |
| CN113975241B (en) | Preparation process of trelagliptin succinate tablets | |
| CN103610658B (en) | Immunomodulator slow-release preparation and preparation method thereof | |
| CN102499891B (en) | Moisture-proof preparation method for solvent-free solid preparation | |
| CN107468660A (en) | A kind of new technology for preparing roflumilast tablet | |
| CN104721207B (en) | A kind of pharmaceutical composition | |
| CN204337311U (en) | High efficient mixed facility for granulating | |
| CN103142525A (en) | Olanzapine gastric soluble tablets and preparation method thereof | |
| CN113244180A (en) | Hydroxychloroquine sulfate pharmaceutical preparation | |
| CN110575442B (en) | Fermented cordyceps sinensis powder tablet | |
| CN106176655B (en) | Penicillin V potassium tablet and preparation process thereof | |
| CN102772403B (en) | Pramipexole preparation and preparation method thereof | |
| CN104666263B (en) | A kind of tablet containing Levetiracetam and preparation method thereof | |
| CN109432027B (en) | Preparation process of amoxicillin dispersible tablets | |
| CN103142533B (en) | Enteric coated tablet of etoposide | |
| CN105902513B (en) | Enteric-coated aureomycin pellet premix and preparation method thereof | |
| CN106389368A (en) | Sodium valproate sustained release preparation as well as preparation process and applications thereof | |
| CN106913544A (en) | A kind of Gefitinib tablet of Fast Stripping and preparation method thereof | |
| CN109662948B (en) | Platelet aggregation inhibitor and preparation method thereof | |
| CN108309947A (en) | A kind of tablet and preparation method thereof of benzene sulphur bepotastine | |
| CN102600475B (en) | Pharmaceutical pellet cores and preparation method thereof | |
| CN103705482A (en) | Preparation method of tiopronin tablets | |
| CN113521021B (en) | Tablet containing rupatadine fumarate and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150225 |
|
| WD01 | Invention patent application deemed withdrawn after publication |