CN104353181A - Implanted spiral electrode and manufacturing method thereof - Google Patents
Implanted spiral electrode and manufacturing method thereof Download PDFInfo
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- CN104353181A CN104353181A CN201410638552.5A CN201410638552A CN104353181A CN 104353181 A CN104353181 A CN 104353181A CN 201410638552 A CN201410638552 A CN 201410638552A CN 104353181 A CN104353181 A CN 104353181A
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- helical body
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Abstract
The invention discloses an implanted spiral electrode and a manufacturing method of the implanted spiral electrode, and belongs to the range of medical instruments. The implanted spiral electrode is of a flexible structure formed by first spiral bodies and a second spiral body, and a nerve tract is sleeved with the flexible structure. One ends of metal spiral wires in two insulation sleeve pipes are connected with stimulation contacts on the two first spiral bodies respectively, a traction line penetrates through one first spiral body and penetrates out of the other first spiral body, and a stimulation screw is formed by the traction line, the metal spiral wires and the simulation contacts. The stimulation contacts of a hollow flat annular structure is adopted, a silane coupling agent layer on the surface of the traction line and a lubricating coating on the surface of a connecting guide pipe are added, the connecting strength of all the parts of the simulation screw and a locating screw is enhanced, the glutinousness of the connecting guide pipe and human tissue is reduced, and the mechanical injury and physiological injury of the whole electrode to nerves can be reduced.
Description
Technical field
The invention belongs to medical apparatus and instruments scope, particularly a kind of implanted screw electrode and preparation method thereof, is a kind of electrode of the implanted Intradermal affected area for peripheral nervous electrical stimulating therapy specifically.
Background technology
The application of peripheral nervous electrical stimulation technology is epilepsy, and the patient of depression, pains and other diseases provides a kind of means of auxiliary therapy.Cuff electrode and screw electrode are two kinds of electrodes conventional in peripheral nervous electrical stimulating therapy, and because cuff electrode may produce the side effect of pressuring nerve in long-term implantation application, the electrode of helical structure becomes the clinical first-selection of peripheral nerve stimulation gradually.
The existing screw electrode limitation for peripheral nervous electricity irritation is, frictional force between silicone rubber tube and tissue is larger, when the position residing for electrode is clashed into or other external force affect, the phenomenon of the even overall fracture of easy generation local laceration, result is that electricity irritation cannot arrive target area.Existing bibliographical information, once occurred causing lead rupture for above-mentioned reasons clinically, and patient again must undergo surgery and changes the case of electrode.In addition, polyester line in electrode stimulating end spiral structure body, stimulate the cohesive of contact and macromolecular material poor, when electrode is implanted or take out, easily there is coming off of polyester line, and stimulate the displacement of contact (time serious, can depart from completely with macromolecular material), and stimulate contact mostly to be foil, its displacement easily causes mechanical damage to nerve, be shifted simultaneously and easily produce leakage current, thus nontarget area near vagus nerve stimulation, cause comparatively serious side effect, as cough, sore throat etc.Therefore, reduce the risk that patients clinical uses, improve the effectiveness of peripheral nerve stimulation, preparing highly reliable peripheral nervous implanted electrode has important meaning.
Summary of the invention
The object of the invention is to propose a kind of implanted screw electrode and preparation method thereof; It is characterized in that, described implanted screw electrode is a kind of implanted screw electrode for peripheral nerve stimulation be wrapped on nerve tract N, the flexible structure be made up of the first helical body 1, second helical body 6; Wherein the first helical body 1 is divided into two sections; After the circular hole of draught line 3 through stimulation contact 2, after running through two section of first helical body 1 inside respectively, pass from the two ends of the first helical body 1; It is inner that draught line 3 runs through the second helical body 6, passes from the second helical body 6 two ends; Insulated sleeve 4 inner sleeve has metal spiral wire 5; Metal spiral wire 5 one end in two insulated sleeve 4 is connected with the stimulation contact 2 in two section of first helical body 1 respectively, and the other end exposes insulated sleeve 4 respectively; Metal spiral wire 5, then insulated sleeve 4 is fixed in the second helical body 6 by locating ring 7.
Described two insulated sleeve determine the relative position between each several part by locating ring 7.
Described first helical body, stimulation contact and draught line composition stimulate the flexible structure of spiral, and wherein the first helical body and draught line form by with biocompatible high-molecular organic material; Contact is stimulated to be the platinumiridio material with electric conductivity.
Described stimulation contact is the hollow flat circulus comprising three circular holes, stimulates contact entirety to be embedded in the hurricane band of the first helical body; Under stimulating the upper surface of contact to be placed in the outer surface of the first helical body hurricane band; Stimulate the inner surface of the exposed hurricane band in the first helical body in lower surface of contact, directly contact with nerve tract N; The interval of its upper surface, moderate stimulation contact and lower surface is less than the thickness of the first helical body hurricane band; Flat annular structure strengthens the bonding strength stimulating contact and the first helical body, avoids stimulating contact to be shifted or comes off and cause mechanical damage to nerve.
Described draught line is successively through three circular holes stimulating contact, and two ends are exposed to stimulate outside contact at flat annular; Draught line is exposed after stimulating the two ends outside contact to run through the first helical body inside, passes from two ends of the first helical body; The diameter of three circular holes on stimulation contact is 1.5 ~ 2 times of draught line diameter; The silicone rubber silane coupling agent of the biocompatible macromolecular material of draught line surface-coated, strengthen the bonding strength with the first helical body material, avoid because draught line is separated the displacement causing and stimulate contact with helical body, so that the mechanical damage stimulating contact to cause nerve when implanting or remove electrode.
Described insulated sleeve is the flexible structure that macromolecular material is made; In the silicone lubricant of its extexine coating biocompatible polymer material, reduce human body neck neck position movable time, the probability of the conduit rupture that the viscous of connecting duct and peripheral nerve tissue causes.
Described metal spiral wire is four helical spring type structures, and its material is long-term implanted rustless steel, and its diameter is 0.2 ~ 0.25mm, and described metal spiral wire is placed in insulated sleeve, and its traversing through end is placed in flat annular stimulates contact inner; Insulated sleeve end is connected with the first helical body, and the silicon rubber bonder that its junction applies biocompatible macromolecular material forms end socket.
The flexible structure of described second helical body, locating ring and draught line composition setting screw, makes by with biocompatible high-molecular organic material; Wherein draught line runs through the second helical body inside, and passes from the two ends of the second helical body.
The material of described the first helical body, the second helical body and locating ring by making with biocompatible high-molecular organic material is silastic material or polyurethane material, and draught line is the polyester materials such as biocompatible polyethylene terephthalate.
Described locating ring makes two insulated sleeve pass, and in locating ring vacant position filled silicon rubber bonding agent, for fixing the relative position that two of the first helical body stimulate spirals and the setting screw of the second helical body, formation implanted screw electrode.
The manufacture method of described implanted screw electrode, is characterized in that, comprises following step
1) get foil and the metal spiral wire of three circular holes, between holes one end of metal spiral wire being welded on foil surfaces, the junction point of welding and foil are formed and stimulate contact;
2) stimulate three circular holes of contact to penetrate successively from lamellar draught line to pass, and the foil with draught line and stimulation contact is turned to flat annular structure, form the stimulation contact in the first helical body, subsequently at the silicone rubber silane coupling agent stimulating the biocompatible macromolecular material of draught line surface-coated outside contact;
3) step 2) stimulation contact in two the first helical body obtaining and draught line be placed in stimulate spiral mould screw rod on, screw rod and metal spiral wire are placed in simultaneously stimulates spiral mould relevant position, by silicone rubber and/polyurethane, adopt silicon rubber vulcanization or Shooting Technique to inject to stimulate in spiral mould, be processed to form stimulation spiral; Secondly draught line is wound on the screw rod of setting screw mould, and screw rod is placed in setting screw mould relevant position, by silicone rubber or polyurethane, adopt in sulfuration or Shooting Technique injecting electrode spiral mould, be processed to form the setting screw comprising the second helical body and draught line;
4) provide metal spiral wire is penetrated flexible insulating sleeve after pass, flexible insulating sleeve one end is connected with stimulation spiral, use subsequently the silicon rubber bonder of biocompatible macromolecular material in junction bonding formation end socket, and apply the silicone lubricant of biocompatible macromolecular material at flexible insulating sleeve extexine, form connecting duct;
5) by step 3) the stimulation spiral that obtains and setting screw be placed in the relevant position of positioning tool, two connecting ducts pass the locating ring of setting screw, and use silicon rubber bonder to fill in the vacant position of locating ring and fix, form implanted screw electrode.
Beneficial effect of the present invention is compared with prior art, the present invention adopts the stimulation contact of the flat annular structure of hollow, with the addition of the primer layer on draught line surface and the lubricant coating on connecting duct surface, enhance the bonding strength stimulating spiral and setting screw each several part, reduce the viscosity of connecting duct and tissue, electrode integral can be reduced for the mechanical damage of nerve and physiological damage.
Accompanying drawing explanation
Fig. 1 a is stimulation helical structure schematic diagram of the present invention.
Fig. 1 b is setting screw structural representation of the present invention.
Fig. 2 a is the stimulation contact structure schematic diagram of flat annular.
Fig. 2 b is the stimulation contact structure schematic diagram launched.
Fig. 3 is the structural representation after electrode assembling.
In figure: 1, the first helical body, 2, stimulate contact, 3, draught line, 4, insulated sleeve, 5, metal spiral wire, the 6, second helical body, 7, locating ring
Detailed description of the invention
The present invention proposes a kind of implanted screw electrode and preparation method thereof.Below in conjunction with drawings and Examples, the present invention is explained.
Fig. 1 a, Fig. 1 b, Fig. 2, Fig. 3 show structure of the present invention, and what described implanted screw electrode was made up of the first helical body 1, second helical body 6 is enclosed within (as Suo Shi Fig. 1, Fig. 3) flexible structure on nerve tract N; Wherein the first helical body 1 is divided into two sections, forms the stimulation spiral stimulating contact 2 containing two; Second helical body 6 is a setting screw.After the circular hole of draught line 3 through stimulation contact 2, after running through two section of first helical body 1 inside respectively, pass from the two ends of the first helical body 1; It is inner that draught line 3 runs through the second helical body 6, passes from the second helical body 6 two ends.Metal spiral wire 5 one end in two insulated sleeve 4 stimulates contact 2 to be connected with two in the first helical body 1 respectively; The junction point coated with adhesive of insulated sleeve helical body in April first 1 forms end socket.The other end exposes insulated sleeve 4 respectively, uses as connection signal input equipment; This metal spiral wire 5 is fixed in insulated sleeve 4, forms connecting duct; Connecting duct is fixed in the second helical body 6 (as shown in Figure 3) through the locating ring 7 of setting screw.
Spiral and setting screw is stimulated to select and biocompatible high-molecular organic material (as silicone rubber or polyurethane etc.).Under stimulating upper surface, contact 2 to be placed in the outer surface of the first helical body 1, lower surface is exposed to the inner surface of the first helical body 1.Draught line selects biocompatible high-molecular organic material, the polyester materials such as polyethylene terephthalate, by draught line through the circular hole stimulated on contact 2, and at the silicone rubber silane coupling agent of surface-coated biocompatible polymer material, be placed in the first helical body 1 inner.Wherein, stimulate the metal of the stimulation contact of spiral can select platinum, iridium, and platinumiridio.The insulated sleeve 4 of connecting duct selects biocompatible high-molecular organic material, silicone rubber or polyurethane etc., the silicone lubricant of outer surface macromolecular material; Metal spiral wire has helical spring type structure, and wherein metal is platinum, iridium or platinumiridio material.
Second helical body of setting screw selects biocompatible high-molecular organic material, silicone rubber or polyurethane etc.; Draught line selects biocompatible high-molecular organic material, the polyester materials such as polyethylene terephthalate, and the silicone rubber silane coupling agent of the biocompatible macromolecular material of surface-coated is placed on the second helical body inside.
By the relevant position stimulating spiral and setting screw to be placed in positioning tool, two connecting ducts pass the locating ring of setting screw, and use silicon rubber bonder to fill in the vacant position of locating ring and fix, and are processed to form implanted screw electrode.
Implementation step of the present invention is described in detail as follows:
Embodiment one
First by the metal spiral wire 5 of 4, be welded on the foil with three circular holes by the method for laser weld or resistance spot welding, formed and stimulate contact 2; Passed in the hole of three foil respectively by draught line 3 as shown in Figure 2 b, draught line 3 is the polyester materials such as biocompatible polyethylene terephthalate.By the hollow flat circulus be coiled into shown in Fig. 2 a of the stimulation contact 2 of foil, ensure that draught line 3 stimulates two ends, contact 2 to pass from ring-type, subsequently exposed draught line 3 top layer outside flat annular structure is applied the silicone rubber silane coupling agent of biocompatible macromolecular material.Metal spiral wire 5 is penetrated in insulated sleeve 4, insulated sleeve 4 is connected to the first helical body 1 stimulating spiral, at the silicon rubber bonder of the compatible macromolecular material of junction filled biomass, form end socket, insulated sleeve 4 is biocompatible silicone rubber or polyurethane, with the top layer of biocompatible lubricant application flexible insulating sleeve 4, form connecting duct.
By draught line, contact and metal spiral wire is stimulated to be fixed on the correspondence position stimulating spiral sulfurizing mould, filler method is adopted to insert in the mould with screw rod by the material of main part such as solid silicone rubber or polyurethane subsequently, take out after silicone rubber is high temperature vulcanized, formed and stimulate spiral, as shown in Figure 1a; Adopt same sulfuration process, draught line is fixed on the correspondence position of setting screw mould, form setting screw, as shown in Figure 1 b.
By the relevant position stimulating spiral and setting screw to be placed in positioning tool, two stimulate the distance of contact to be about 8mm, two connecting ducts pass the locating ring of setting screw, and use silicon rubber bonder to fill in the vacant position of locating ring and fix, form implanted screw electrode (as shown in Figure 3).
Embodiment two
First by the metal spiral wire 5 of 4, be welded on the foil with three circular holes by the method for laser weld or resistance spot welding, formed and stimulate contact 2; And draught line 3 is passed respectively in three of foil holes, draught line 3 is the polyester materials such as biocompatible polyethylene terephthalate.By the hollow flat circulus be coiled into shown in Fig. 2 a of the stimulation contact 2 of foil, ensure that draught line 3 stimulates two ends, contact 2 to pass from ring-type, subsequently exposed draught line 3 top layer outside flat annular structure is applied the silicone rubber silane coupling agent of biocompatible macromolecular material.By draught line, stimulate contact and metal spiral conductor flat to be placed in mould, adopting filler method will insert strip for biocompatible solid silicone rubber or polyurethane subsequently stimulates in spiral mould, takes out after silicone rubber one step cure; The silicone rubber of taking-up and stimulation contact are wrapped on the round bar of regulation internal diameter, carry out post vulcanization, formed and stimulate spiral (as shown in Figure 1a).As shown in Figure 1 b, adopt same technique, draught line is fixed on the correspondence position of strip setting screw mould, after carrying out one step cure and post vulcanization respectively, form setting screw.
Metal spiral wire 5 is penetrated in insulated sleeve 4, insulated sleeve 4 is connected to the first helical body 1 stimulating spiral, at the silicon rubber bonder of the compatible macromolecular material of junction filled biomass, form end socket, insulated sleeve 4 is biocompatible silicone rubber or polyurethane, with the top layer of biocompatible lubricant application flexible insulating sleeve, form connecting duct.。
By the relevant position stimulating spiral and setting screw to be placed in positioning tool, two stimulate the distance of contact to be about 8mm, two connecting ducts pass the locating ring of setting screw, and use bonding agent filling in the vacant position of locating ring and fix, form implanted screw electrode (as shown in Figure 3).
Claims (10)
1. an implanted screw electrode; It is characterized in that, described implanted screw electrode is a kind of implanted screw electrode for peripheral nerve stimulation, the flexible structure be enclosed within nerve tract be made up of the first helical body (1), the second helical body (6); Wherein the first helical body (1) is divided into two sections; After the circular hole of draught line (3) through stimulation contact (2), after running through two section of first helical body (1) inside respectively, pass from the two ends of the first helical body (1); It is inner that draught line (3) runs through the second helical body (6), passes from the second helical body (6) two ends; Insulated sleeve (4) inner sleeve has metal spiral wire (5); Metal spiral wire (5) one end in two insulated sleeve (4) is connected with the stimulation contact (2) on two section of first helical body (1) respectively; The other end exposes insulated sleeve (4) metal spiral wire (5) respectively, and insulated sleeve (4) is then fixed in the second helical body (6) by locating ring (7).
2. a kind of implanted screw electrode according to claim 1; It is characterized in that, described two insulated sleeve are by the relative position between locating ring determination each several part.
3. a kind of implanted screw electrode according to claim 1; It is characterized in that, described first helical body and draught line form by with biocompatible high-molecular organic material, stimulate contact to be the platinum with electric conductivity, iridium or platinumiridio material.
4. a kind of implanted screw electrode according to claim 1; It is characterized in that, described stimulation contact is the hollow flat circulus comprising three circular holes, stimulates contact entirety to be embedded in the hurricane band of helical body; The upper surface of contact is stimulated to be placed in the inside of the first helical body hurricane band; Stimulate the inner surface of the exposed hurricane band in the first helical body in lower surface of contact, directly contact with nerve tract; The interval of its upper surface, moderate stimulation contact and lower surface is less than the thickness of the first helical body hurricane band; Flat annular structure strengthens the bonding strength stimulating contact and the first helical body, avoids stimulating contact to be shifted or comes off and cause mechanical damage to nerve.
5. a kind of implanted screw electrode according to claim 1; It is characterized in that, described draught line is successively through three circular holes stimulating contact, and two ends are exposed to stimulate outside contact at flat annular; Draught line is exposed after stimulating the two ends outside contact to run through the first helical body inside, passes from the two ends of the first helical body; The diameter penetrating punched out on stimulation contact is 1.5 ~ 2 times of draught line diameter; The silicone rubber silane coupling agent of draught line surface-coated macromolecular material, strengthen the bonding strength with the first helical body material, avoid because draught line is separated the displacement causing and stimulate contact with helical body, so that the mechanical damage stimulating contact to cause nerve when implanting or remove electrode.
6. a kind of implanted screw electrode according to claim 1; It is characterized in that, described insulated sleeve is the flexible structure that macromolecular material is made; Apply the silicone lubricant of biocompatible macromolecular material at its extexine, reduce human body neck neck position movable time, the probability of the conduit rupture that the viscous of connecting duct and peripheral nerve tissue causes.
7. a kind of implanted screw electrode according to claim 1; It is characterized in that, described metal spiral wire is four helical spring type structures, and its material is long-term implanted rustless steel, and its diameter is 0.2 ~ 0.25mm, and described metal spiral wire is placed in insulated sleeve, and its traversing through end is placed in flat annular stimulates contact inner; Insulated sleeve is connected with the first helical body, and the silicon rubber bonder of its junction coating macromolecular material forms end socket; The flexible structure of described second helical body, locating ring and draught line composition setting screw, makes by with biocompatible high-molecular organic material; Wherein draught line runs through the second helical body inside, and passes from the two ends of the second helical body.
8. a kind of implanted screw electrode according to claim 1; It is characterized in that, the material of described the first helical body, the second helical body and locating ring by making with biocompatible high-molecular organic material is silastic material or polyurethane material, and draught line is the polyester materials such as polyethylene terephthalate.
9. a kind of implanted screw electrode according to claim 1; It is characterized in that, described locating ring makes two insulated sleeve pass, and in locating ring vacant position filled silicon rubber bonding agent, for fixing the relative position that two of the first helical body stimulate the setting screw of spirals and the second helical body.
10. a manufacture method for implanted screw electrode, is characterized in that, comprises following step
1) get foil and the metal spiral wire of three circular holes, between holes one end of metal spiral wire being welded on foil surfaces, the junction point of welding and foil are formed and stimulate contact;
2) stimulate three circular holes of contact to penetrate successively from lamellar draught line to pass, and the foil with draught line and stimulation contact is turned to flat annular structure, form the stimulation contact in the first helical body, subsequently at the silicone rubber silane coupling agent stimulating the biocompatible macromolecular material of draught line surface-coated outside contact;
3) step 2) stimulation contact in two the first helical body obtaining and draught line be placed in stimulate spiral mould screw rod on, screw rod and metal spiral wire are placed in simultaneously stimulates spiral mould relevant position, by silicone rubber and/polyurethane, adopt silicon rubber vulcanization or Shooting Technique to inject to stimulate in spiral mould, be processed to form stimulation spiral; Secondly draught line is wound on the screw rod of setting screw mould, and screw rod is placed in fixing spiral mould relevant position, by silicone rubber or polyurethane, adopt in sulfuration or Shooting Technique injecting electrode spiral mould, be processed to form the setting screw comprising the second helical body and draught line;
4) provide metal spiral wire is penetrated flexible insulating sleeve after pass, flexible insulating sleeve one end is connected with stimulation spiral, use subsequently the silicon rubber bonder of biocompatible macromolecular material in junction bonding formation end socket, and apply the silicone lubricant of biocompatible macromolecular material at flexible insulating sleeve extexine, form connecting duct;
5) by step 3) the stimulation spiral that obtains and setting screw be placed in the relevant position of positioning tool, two connecting ducts pass the locating ring of setting screw, and use silicon rubber bonder to fill in the vacant position of locating ring and fix, form implanted screw electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410638552.5A CN104353181B (en) | 2014-11-06 | Implanted screw electrode and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410638552.5A CN104353181B (en) | 2014-11-06 | Implanted screw electrode and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104353181A true CN104353181A (en) | 2015-02-18 |
| CN104353181B CN104353181B (en) | 2017-01-04 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108939287A (en) * | 2018-06-04 | 2018-12-07 | 清华大学 | The manufacturing method and nerve tract of flexible screw electrode detect therapeutic device |
| CN109954225A (en) * | 2017-12-25 | 2019-07-02 | 复旦大学 | Deformable light heredity multiple spot stimulation device |
| CN111330148A (en) * | 2020-03-06 | 2020-06-26 | 清华大学 | Implantable flexible nerve electrode manufactured in layered mode and preparation method thereof |
| CN111491691A (en) * | 2017-07-28 | 2020-08-04 | 加尔瓦尼生物电子有限公司 | Electrode device for nerve stimulation |
| CN111729193A (en) * | 2020-06-24 | 2020-10-02 | 北京品驰医疗设备有限公司 | Isolating ring, composite contact, electrode and manufacturing method of electrode |
| CN111939482A (en) * | 2020-08-10 | 2020-11-17 | 中国科学院上海微系统与信息技术研究所 | Optical device of flexible implanted nerve photoelectric electrode and design and preparation method thereof |
| CN113577536A (en) * | 2020-04-30 | 2021-11-02 | 浙江迈达佩思医疗科技有限公司 | Implanted lead electrode, preparation method and sacral nerve stimulator |
| CN113907761A (en) * | 2021-10-09 | 2022-01-11 | 中国人民解放军军事科学院军事医学研究院 | Bipolar implanted myoelectricity electrode assembly for stimulation and recording and application method thereof |
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| CN2887336Y (en) * | 2006-03-10 | 2007-04-11 | 清华大学 | Electrode catheter of implanted nerve stimulator |
| US8478428B2 (en) * | 2010-04-23 | 2013-07-02 | Cyberonics, Inc. | Helical electrode for nerve stimulation |
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| US4979511A (en) * | 1989-11-03 | 1990-12-25 | Cyberonics, Inc. | Strain relief tether for implantable electrode |
| CN2887336Y (en) * | 2006-03-10 | 2007-04-11 | 清华大学 | Electrode catheter of implanted nerve stimulator |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111491691A (en) * | 2017-07-28 | 2020-08-04 | 加尔瓦尼生物电子有限公司 | Electrode device for nerve stimulation |
| CN111491691B (en) * | 2017-07-28 | 2024-02-02 | 加尔瓦尼生物电子有限公司 | Electrode device for nerve stimulation |
| CN109954225A (en) * | 2017-12-25 | 2019-07-02 | 复旦大学 | Deformable light heredity multiple spot stimulation device |
| CN108939287B (en) * | 2018-06-04 | 2020-09-04 | 清华大学 | Method for manufacturing flexible spiral electrode and nerve bundle detection and treatment device |
| CN108939287A (en) * | 2018-06-04 | 2018-12-07 | 清华大学 | The manufacturing method and nerve tract of flexible screw electrode detect therapeutic device |
| CN111330148B (en) * | 2020-03-06 | 2022-04-12 | 清华大学 | Implantable flexible nerve electrode manufactured in layered mode and preparation method thereof |
| CN111330148A (en) * | 2020-03-06 | 2020-06-26 | 清华大学 | Implantable flexible nerve electrode manufactured in layered mode and preparation method thereof |
| CN113577536A (en) * | 2020-04-30 | 2021-11-02 | 浙江迈达佩思医疗科技有限公司 | Implanted lead electrode, preparation method and sacral nerve stimulator |
| CN113577536B (en) * | 2020-04-30 | 2024-02-27 | 浙江迈达佩思医疗科技有限公司 | Implantable lead electrode, preparation method and sacral nerve stimulator |
| CN111729193A (en) * | 2020-06-24 | 2020-10-02 | 北京品驰医疗设备有限公司 | Isolating ring, composite contact, electrode and manufacturing method of electrode |
| CN111939482A (en) * | 2020-08-10 | 2020-11-17 | 中国科学院上海微系统与信息技术研究所 | Optical device of flexible implanted nerve photoelectric electrode and design and preparation method thereof |
| CN111939482B (en) * | 2020-08-10 | 2022-02-25 | 中国科学院上海微系统与信息技术研究所 | Optical device of flexible implanted nerve photoelectric electrode and design and preparation method thereof |
| CN113907761A (en) * | 2021-10-09 | 2022-01-11 | 中国人民解放军军事科学院军事医学研究院 | Bipolar implanted myoelectricity electrode assembly for stimulation and recording and application method thereof |
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