CN104330580A - Pipetting equipment and method for controlling pipetting equipment or producing dosage of liquid product - Google Patents
Pipetting equipment and method for controlling pipetting equipment or producing dosage of liquid product Download PDFInfo
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- CN104330580A CN104330580A CN201410555764.7A CN201410555764A CN104330580A CN 104330580 A CN104330580 A CN 104330580A CN 201410555764 A CN201410555764 A CN 201410555764A CN 104330580 A CN104330580 A CN 104330580A
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Abstract
The invention relates to pipetting equipment. The pipetting equipment at least comprises two groups of pipetting pipes (9a, 9b, 9c and 9d), wherein each group of pipetting pipes (9a, 9b, 9c and 9d) can be operably connected to a public extraction port (7) by virtue of ON/OFF valves (11a, 11b, 11c and 11d); the public extraction port (7) can be connected with pumping equipment (3); the valves (11a, 11b, 11c and 11d) are controlled by a timing control unit (15); by virtue of the control of the timing control unit (15) on the valves (11a, 11b, 11c and 11d), at least two groups of pipetting pipes (9a, 9b, 9c and 9d) are operably connected with the extraction port (7) in a regular multiplexing mode.
Description
The divisional application that the application is international filing date is on May 14th, 2010, application number is 201080004122.8 (international application no is PCT/EP2010/056662), denomination of invention is the application for a patent for invention of " method of liquid shifting equipment and control liquid shifting equipment or production fluid product dosage ".
Technical field
The present invention relates to the field by accurate predetermined preparation and treat liquid dosage, these liquid dosages have low to such as hundreds of the very low dose of of liter (nano-liter) of receiving thus.Such liquid handling technology is used in the scope about medical science, chemistry or biochemical analysis especially, such as, be used in medicine, medical science or grocery trade laboratory.
Background technology
Thus, the most important thing is the little liquid sample extracting accurate known volume as coupon (probe) such as to be analyzed, and usually extract by two-forty.Secondly importantly, such as, when the blood analysis about a large amount of population, the infectious disease of outburst must be followed the tracks of rapidly.
Transfer pipet extracting liquid from multiple container is adopted to be known.Thus, transfer pipet is transported to container and aims at container, is lowered to soak in respective liquid in a reservoir.For every root transfer pipet, be provided with the valve and pumping equipment that are connected.By valve with the corresponding control of pumping equipment, every root transfer pipet extracts the liquid of corresponding dosage from container.In order to determine the volume of extracted dosage (sample) by the deviation of only very little number percent, make it accurately to conform to predetermined, specified volume, must by pumping equipment, complete many high requests by valve and by corresponding control.
" specified " volume of dosage is interpreted as required dosage by us.Ideally, the dosage produced should have the volume equal with nominal volume.
The liquid dosages be once drawn in transfer pipet is transported to target location usually in transfer pipet, and at this place, they are discharged from transfer pipet by the corresponding control of valve and pumping equipment.Subsequently, if necessary, can be cleaned transfer pipet with cleaning solution.
Extraction step is performed as and all valves and pumping equipment (each pumping equipment is connected on a transfer pipet) is side by side operated or temporally interleaved.
Summary of the invention
An object of the present invention is, a kind of alternative liquid shifting equipment and a kind of alternative method for controlling liquid shifting equipment or generation fluid product dosage are provided.
According to the present invention, this object is realized by a kind of liquid shifting equipment, and this liquid shifting equipment comprises at least two group transfer pipets.Often organize transfer pipet through shared extraction on port can be operably connected to by control ON/OFF-(opening/closing) valve.Extract port and can be connected to pumping equipment.Valve is controlled by timing control module.Timing control module is designed for, and is controlled by valve, sets up at least two group transfer pipets be operatively connected for extraction the corresponding of port by timing multiplex mode.
Thus, a pumping equipment is adopted at least two group transfer pipet common lands.Such pumping equipment can be see off to the expedition pump of the pipe-line-network feed in Architectural Equipment or vacuumize station, can be intensively for the pumping unit of multiple distinct device, or for the different pumping units of liquid shifting equipment, it is integrated into liquid handling device (this liquid handling device comprises described liquid shifting equipment) or away from this liquid handling device.
Run through this instructions and claims, we should be understood to a kind of tubular part at said " transfer pipet ", this tubular part has an opening of extraction for fluid product dosage and release, and there is the second opening, controllably apply aspiration vacuum (aspirating vacuum) at this second opening part.
In addition, run through this instructions and claims, we said " group of transfer pipet " should be understood as that one or more than a transfer pipet, and it has a shared opening for applying aspiration vacuum.Thus, if such one group comprises more than a transfer pipet, then in an end of whole transfer pipet, their opening is in open communication.Obviously, each transfer pipet in a group is operated in parallel, and aspiration vacuum is side by side applied on these transfer pipets and from these transfer pipets and removes.
According to the present invention, in order to extract corresponding dosage, one group of transfer pipet is operably connected to share and extracts on port after another group transfer pipet, and this shares extraction port and is operably connected on shared pumping equipment.
The quantity being equipped to the complex precise pump often organizing transfer pipet is routinely reduced significantly.If the conventional liquid shifting equipment such as with ten groups of transfer pipets with ten groups of pumping equipments, then must only need one group of pumping equipment according to liquid shifting equipment of the present invention.
Thus, structural volume and the weight of transfer pipet equipment is significantly decreased.
Thus, according to multiplexing technique of the present invention, such as, with regard to constructing with regard to workload, price, structural volume and weight, there is the remarkable advantage of (parallel) extraction technique being better than walking abreast.If recognize that whole liquid shifting equipment is usually to move to target location from crawl position with high acceleration and mobilely to return, then the latter's (weight) is particular importance.By having the reduction of the weight of the liquid shifting equipment of the single pumping equipment of integration, higher transport acceleration can be applied, and/or the driving force that reduction delivery system must bear, and thus optimize the subsequent processing steps of liquid dosages process.
As already mentioned, importantly, the volume of the dosage extracted will nominal volume as far as possible accurately with corresponding equal.
Timing according to the present invention is multiplexed, under the form of its most broad sense, make the time slot that suitably limits and often organize transfer pipet and be connected, during time slot of this suitable restriction, on the extraction port that such group is operably connected to shared pumping equipment or be connected on shared pumping equipment.The width of these time slots can the most accurately be controlled, and can the most accurately change.According to timing multiplexing technique of the present invention,---this timing multiplexing technique is used for operating the single pumping equipment of at least two or more groups transfer pipet---has maximum dirigibility, so that: operate whole groups by multiplexing modes; Side by side and thus two groups or more group is operated in parallel; By each group, clustering is to become the cluster of group in addition, and the cluster and other cluster etc. of described group are operated in parallel and be timed multiplexed.
In one embodiment of the invention (unless there are contradiction, otherwise this embodiment can be combined with other embodiment any of the present invention), at least one group of at least two group transfer pipets comprises an independent transfer pipet.
In another embodiment of the present invention (unless there are contradiction, otherwise this embodiment can be combined with other embodiment any of the present invention), transfer pipet equipment comprises shared pumping equipment, and this shared pumping equipment is operably connected to and extracts on port.In this embodiment, pumping equipment is the part according to liquid shifting equipment of the present invention.
In an embodiment of pumping equipment, such pumping equipment comprises gear-type pump, preferably ring gear pump, as such as described in EP 0 852 674 B1.That this causes very accurately operating and the liquid shifting equipment of highly compact.
In another embodiment of the present invention (unless there are contradiction, otherwise this embodiment can be combined with other embodiment any of the present invention), in fact the timing control module arranged in order to timing is multiplexed is controllable, alternatively and selectively to set up at least two group transfer pipets for extracting being operatively connected of port simultaneously.Thus, people can select neatly by timing multiplexing modes or with the group of operation in parallel mode transfer pipet.
In another embodiment of the present invention (unless there are contradiction, otherwise this embodiment can be combined with other embodiment any of the present invention), pumping equipment is controlled so as to set up at least two group transfer pipets in the control by valve by timing multiplex mode and is operating for the period that is operatively connected extracting port always.Which avoid and switch on and off pumping equipment.In this embodiment, extract dosage volume only limited by the controlled operation of valve, namely only open wide the time span of period by respective valve and limit.
Can select in embodiment (unless there are contradiction at one of the present invention, otherwise this embodiment can be combined with other embodiment any of the present invention), pumping equipment is controlled so as to, with set up at least two group transfer pipets by the control of valve by timing multiplex mode and be operatively connected synchronizedly for what extract port, ON and OFF interrupt continuous operate.In this embodiment (it is being preferred now), the corresponding time span that the volume of the dosage extracted only is operated by power and the pumping equipment of pumping equipment and limiting.
In another embodiment of the present invention (unless there are contradiction, otherwise this embodiment can be combined with other embodiment any of the present invention), valve by adjustment make when by control from OFF to ON state or control with being reversed time spray or extract insignificant volume.Thus, the operation of valve is on the amount of the impact of the precision of draw volume only negligible quantity.
In another embodiment of the present invention (unless there are contradiction, otherwise this embodiment can be combined with other embodiment any of the present invention), from pumping equipment, flow sensor is being set in the shared pipeline of transfer pipet group.Thus, the flow of pumping equipment can be gone to single flow sensor monitoring, such as, indicate one of transfer pipet whether to block.
According to a kind of liquid handling device of the present invention---this liquid handling device comprise according to of the present invention one or more than one at its specific embodiment in liquid shifting equipment---there is the economy advantage of height, provide a kind of volume little, lightweight, and the liquid shifting equipment that controls can be carried out the most neatly.
According to an embodiment of liquid handling device of the present invention (unless there are contradiction, otherwise this embodiment can be combined with other embodiment any of such device) comprise controlled location driver, this controlled location driver controls the position of liquid shifting equipment along at least two spatial coordinate axles.Thus, liquid shifting equipment is positioned in relevant position with being driven, such as in x/y coordinate system define.
(unless there are contradiction in another embodiment of liquid handling device according to the present invention, otherwise this embodiment can be combined with other embodiment any of such device), controlled location driver by separate mode, control liquid shifting equipment along the 3rd spatial coordinate axle and/or the position of two groups.Also or only can move independently of each other along two coordinate directions and locate these groups at whole three coordinate directions.
Thus, liquid shifting equipment such as becomes relative to z coordinate and drives orientable, and/or transfer pipet group becomes individually relative to the 3rd described spatial coordinate and orientable independently.
Another object of the present invention is, improves the control of liquid shifting equipment, or the production of the liquid dosages of improvement predetermined.This object is realized by the method for at least two liquid dosages for controlling liquid shifting equipment or producing predetermined, and the method comprises:
First group of transfer pipet at least two group transfer pipets is immersed in the first reservoir containing first liquid, first group of transfer pipet is operably connected to extract on port-this extraction port is operably connected on pumping equipment, and set up extraction effect in described extraction port, thus first liquid is drawn in first group of transfer pipet;
Close an ON/OFF valve, an ON/OFF valve is interconnected between described first group of transfer pipet and described extraction port;
Second group of transfer pipet at least two group transfer pipets is immersed in the second reservoir containing second liquid, second group of transfer pipet is operably connected to extract on port-this extraction port is operably connected on pumping equipment, and set up extraction effect in extraction port, thus second liquid is drawn in second group of transfer pipet;
Close the 2nd ON/OFF valve, the 2nd ON/OFF valve is interconnected in second group of transfer pipet and extracts between port;
Thus, opened by the corresponding timing controlled of an ON/OFF valve and the 2nd ON/OFF valve, to from first group of transfer pipet and from second group of transfer pipet to extraction port described in be operatively connected that to carry out timing multiplexed.
Thus, the dosage that can realize low hardware size is produced, and makes the entire lowering of the price of processed in units liquid dosages, and treatment dosage even can also be made to have higher throughput rate.
(unless there are contradiction according to one embodiment of the method for the invention, otherwise this embodiment can be combined with any embodiment of such method), at least one group of transfer pipet at least two group transfer pipets is selected to and comprises an independent transfer pipet.
According to one embodiment of the method for the invention (unless there are contradiction, otherwise this embodiment can be combined with any embodiment of such method), keep carrying out extraction effect in multiplexed period always.
According to one embodiment of the method for the invention (unless there are contradiction, otherwise this embodiment can be combined with any embodiment of such method), the extraction effect in described extraction port is synchronously set up by intermittently, with multiplexed.
According to one embodiment of the method for the invention (unless there are contradiction, otherwise this embodiment can be combined with any embodiment of such method), at least one following option is effective:
First liquid and second liquid are different,
First container and second container are two different containers,
With the immersion carrying out first group of transfer pipet and second group of transfer pipet.
(unless there are contradiction according to one embodiment of the method for the invention, otherwise this embodiment can be combined with any embodiment of such method), be provided with other, selectable operator scheme, wherein, set up first group of transfer pipet and second group of transfer pipet being operatively connected for extraction port simultaneously.
Accompanying drawing explanation
The present invention is further illustrated below by means of accompanying drawing.In accompanying drawing:
Schematically and an embodiment according to liquid shifting equipment of the present invention is shown simplifiedly, this liquid shifting equipment is operated according to a kind of method Fig. 1, the method according to the present invention for generation of or control;
Fig. 2 is the diagram similar to Fig. 1, shows single transfer pipet/valve/pumping unit as prior art, to explain the extraction technique of the also main liquid dosages adopted in the present invention, although prior art and the present invention adopt different realization rate;
Fig. 3 is the chronogram of the control representing in the embodiment in figure 1 included valve quantitatively;
Fig. 4 represents intermittently pump operated chronogram quantitatively, and this chronogram is considered in about the sight of Fig. 3, and this is intermittently pump operated synchronous with the appearance of the time slot of Fig. 3, as a kind of way of realization of the present invention;
Schematically and illustrate according to liquid sample processing device of the present invention simplifiedly, and this liquid sample processing device comprises according to liquid shifting equipment of the present invention Fig. 5.
Embodiment
Fig. 1 schematically shows the embodiment according to liquid shifting equipment 1 of the present invention.Be operably connected to by the illustrative pumping equipment of pump 3 with CD-ROM drive motor 5 in the drawings and extract on port 7.As being illustrated by the broken lines, pumping equipment away from extraction port 7 thus away from liquid shifting equipment, can such as can be realized by the central bunkie station of laboratory building thing, and this central bunkie station is to the vacuum tube gauze supply running through such buildings.However, but in the embodiment of current realization, pumping equipment and liquid shifting equipment integrally, and comprise pump 3.Extracting port 7 is operably connected at least two group transfer pipets, as illustrated, be connected on four groups of transfer pipets 9a, 9b, 9c and 9d through corresponding ON/OFF valve 11a, 11b, 11c, 11d, each valve carries out ON/OFF control by the ON/OFF control signal be applied on control inputs portion (control input) 13a, 13b, 13c, 13d.Each valve can pneumatically or electrically control, and the latter is the situation in the current embodiment realized.The group (sets of pipettes) of transfer pipet can comprise an independent transfer pipet represented in the drawings, however, their whole or selected group (selected sets) can by realizing, as illustrative at 9d ' place dotted line more than the transfer pipet of of being operated in parallel.
Run through this instructions and claims, if we say, valve is " OFF ", then we refer to, valve is " cut out ".
Run through this instructions and claims, if we say, valve is " ON ", then we refer to, valve is " opening wide ".
ON/OFF control signal for valve 11a to 11d is produced and timing by timing control module 15.
The ON/OFF operation of pump 3 is controlled by the control signal going to CD-ROM drive motor control inputs portion 17.The control signal going to control inputs portion 17 is such as also produced by timing control module 15.
Now by means of the known operation that explanation is drawn by Fig. 2, to promote for the understanding of the present invention.
Transfer pipet 9 is operably connected on pumping equipment through ON/OFF valve 11, as being connected on pump 3a.Pump 3a mono-aspect is for good and all filled with liquid medium, this liquid medium by the corresponding operating of pump 3a by forward and transmit rearward, as schematically shown by double-head arrow m.Transfer pipet 9 and normally also have the system of valve 11 to be filled with gaseous state or liquid medium M, this liquid is called " pumped (conveying) medium " by we.
Initial valve 11 is OFF, is namely to close, and prevents liquid pumped (conveying) medium M from from transfer pipet 9, any effusion occurring thus, and this transfer pipet 9 is normally vertically directed.The bottoms level of the liquid pumped (conveying) medium M in transfer pipet 9 is in precalculated position, and this precalculated position is at ozzle 10 place of transfer pipet or be adjacent.
Then the ozzle 10 of transfer pipet 9 is immersed in liquid 21 to be extracted, as represented by dashed line at 10a place in fig. 2.This liquid is called " quantitative liquid " by we.
Pump 3a is activated, and valve 11 is controlled to ON state simultaneously, i.e. opening-wide state.Extraction effect at the extraction port 7a place to pump 7 is delivered to the ozzle 10a of transfer pipet by pumped (conveying) medium M (no matter this pumped (conveying) medium M is liquid or gaseous state): quantitative liquid 21 is drawn in transfer pipet 9.
Once the quantitative liquid of predetermined (dose liquid) 21 enters in transfer pipet 9, valve 11 is just closed.The equipment generally including transfer pipet 9, valve 11 and pump 3a is raised, thus the ozzle 10 of transfer pipet is thrown off with the residue quantitative liquid 21 in container 22.
When valve keeps cutting out, the equipment with transfer pipet 9 can be transmitted now as wished in corresponding uses, and this transfer pipet 9 comprises the dosage of quantitative liquid 21, such as, up to liquid level L indicated in fig. 2.
There is various technology, these technology in order to accurately to determine liquid level L, and thus at the predetermined cross-section place in the inner tube space of transfer pipet 9, determine the volume having extracted quantitative liquid 21 in transfer pipet 9.Such technology such as can based on shading level detection (light-barrier level detection), as known completely in those skilled in the art.
With valve 11 to be rotated under OFF (closedown) state side by side or momently before or after, pump 3a is stopped usually, or says in a broad sense, and the extraction effect for transfer pipet is stopped.
In order to the dosage of quantitative liquid is discharged into target container (not shown) from transfer pipet 9, valve 9 is connected (opening).Such as, the operation of pump 3a is reversed, and thus on one's own initiative liquid dosages 21 is ejected in target container.Here there will be a known the technology differed greatly, for accurately controlling, that is: the liquid 21 of the identical dose volume of volume with the liquid obtained from " source " container 22 being ejected in target container.Importantly it should be noted that in such prior art processes, a pumping equipment is exclusively used in the group of a transfer pipet or a transfer pipet.
After the known general-purpose having explained in the sight of Fig. 2 in automated fluid processing technology field moves liquid technology, let us returns the present invention represented in FIG.
Here, a shared pumping equipment, such as pump 3, be configured to operation more than one group of transfer pipet, as illustrated, operate four groups of transfer pipet 9a to 9d.This by from one group of transfer pipet to another group transfer pipet successively to stem from pump 3 at the extraction effect extracting port 7, in addition timing is multiplexed and realize.Thus, the order of such operation can be selected as desired, and for the sake of clarity, the multiplexed of extraction effect is from 9a to the 9b Fig. 1 to 9c to 9d.
With regard to the providing of medium m and M, those contents described in this article by means of Fig. 2 are available equally.
Fig. 3 represents the chronogram by control signal, valve 11a to 11d being carried out to multiplexed control quantitatively, and these control signals are produced by control module 15, and is applied on the control inputs portion 13a to 13d of respective valve.In figure 3, " cl " expression " closedown " (OFF state), and " op " represents " opening " (ON state) of respective valve.And τ
11ato τ
11dthe corresponding time slot that instruction respective valve 11a to 11d opens wide.T is the whole cycling time of filling whole four groups of transfer pipets.
Thus, generally see Fig. 3, the first valve 11a is at time slot τ
11aperiod is opened.At τ
11aend, valve 11a is closed, and at least substantially side by side, and valve 11b is opened time slot τ
11b, very little time lag may be had.For in the group 9a of multiplexed transfer pipet and the simulation completely of 9b, as just now for described by the extraction port 7 place extraction effect of pump 3, subsequently, the group of transfer pipet 9c and the group of then transfer pipet 9d are at corresponding time slot τ
11c, τ
11dperiod is multiplexed for the extraction effect at port 7 place.
Thus, it is apparent that a time slot is associated with every root transfer pipet.
The width of time slot and time sequencing are freely selectable.Further, if desired, then two or more time slots definitely can set up neatly simultaneously or occur overlappingly, and thus side by side and operate correspondingly selected group concurrently, even if desired, operate whole groups.Further, if desired, then considered one group can be operated during more than one time slot.If this is for the meaning of system clock of fixing time-slot duration such as set up in to(for) whole groups and the dosage of different volumes will when the group place of different transfer pipet be extracted.
Have doses often organizing in transfer pipet to extract, it is proportional that the volume that this dosage has and described group are operably connected to the shared time-slot duration extracted on port 7.Be proved to be in the most current way of realization, gear-type pump, the ring gear pump preferably such as described in EP 0852674 B1, with liquid shifting equipment integrally, form with described equipment the unit being jointly moved and locating thus.
Obviously, by according to τ
11xcorresponding duration accurately open corresponding valve and to pump apply reverse operating, accurately spray the dosage identical with extracted dosage in target location.
As illustrative in figure 3, multiplexed each time slot τ
11xwidth can be selected to equal, or as illustrated be different.Thus by means of these time slots of control τ
11xwidth, the volume of each extraction dosage can be selected respectively.
Although it is possible that during cycle time T operating pumps 3 always, and thus by means of only the ON/OFF control of valve 11a to 11d, perform multiplexed extraction effect, current preferably, intermittently, with multiplexed synchronously operating pumps 3.
Fig. 4 and Fig. 3 represents so interrupted pump operated chronogram explicitly.Here the corresponding ON time τ of pump
ato τ
dcontrol the corresponding extraction volume of each dosage, and multiplexed to timing and extract quantitative liquid in the group of transfer pipet the accurate maintenance of valve 11a to 11d controls.
Valve 11a to 11d should promote the disappearance volume (vanishing volume) of pumped (conveying) medium M (see Fig. 2) in the transition from ON to OFF and from OFF to ON, thus do not make the extraction volume generation deviation of corresponding dosage, this extraction volume is controlled by the mode of operation of pump on the one hand, on the other hand by corresponding time span τ
ato τ
dcontrol.
In order to monitor the suitable function of transfer pipet equipment, can consider to arrange flow sensor apparatus in the shared pipeline from the group of transfer pipet to pumping equipment.Such flow sensor is represented by dashed line in FIG, and is represented by Reference numeral 19.By being monitored flow by means of single flow sensor described position, the failed extraction in arbitrary group in the group of the multiplexed each transfer pipet of timing can be detected.
Fig. 5 schematically shows a kind of liquid treatment equipment or device 33, and this liquid treatment equipment or device 33 have according to liquid shifting equipment 1 of the present invention, and this liquid shifting equipment 1 is integrated in transferring arm 34.Transferring arm 34 has driven movement relative to device framework 35 along x and z direction, as schematically shown in FIG for making transfer pipet 9.Arm 34 itself can move relative to framework 35 with driving along y direction.Valve 11 and pump 3 are integrated in equipment 1.
The group of transfer pipet 9 is immersed in sample container 37 by the controlled motion along z direction, and these sample container 37 have corresponding quantitative liquid.Then the dosage extracted be sent to target container 39 along x and y direction.Thus, in one embodiment, whole groups of transfer pipet are jointly driven along z direction and are located, in other embodiment (not shown), the cluster (groups of sets) of different group (distinct sets) or group can be driven independently of each other along z direction and be located.
In this article, about " comprising the device of liquid shifting equipment ", we are understood in conjunction with instructions and claims, and be conceived to Fig. 5 and understood, such as, what " comprising the device of liquid shifting equipment " related to is whole equipment or arm 34 or the arm with framework, in other words, what relate to is all parts with liquid shifting equipment, until whole equipment.
By all aspects of the present invention, all achieve the remarkable reduction of the hardware size for multiple transfer pipet liquid handling.
Claims (14)
1. a liquid shifting equipment, comprise at least two group transfer pipets, each group transfer pipet in described at least two group transfer pipets is all operably connected to share by means of controllable ON/OFF valve and extracts on port, wherein each controllable ON/OFF valve is all filled with gaseous conveying medium, this shares extraction port can be connected to pumping equipment, described valve is controlled by timing control module, this timing control module is designed for the control by described valve, be operatively connected described at least two group transfer pipets and described extraction port described in setting up by timing multiplex mode, it is characterized in that, described pumping equipment is controlled so as to operating by being operatively connected period described at least two group transfer pipets described in the foundation of timing multiplex mode and described extraction port in the control by described valve always, extract dosage volume only correspondingly open wide the time span of period by described valve and limit.
2. liquid shifting equipment according to claim 1, at least one group in described group comprises an independent transfer pipet.
3. liquid shifting equipment according to claim 1 and 2, comprises shared described pumping equipment, and shared described pumping equipment is operably connected on described shared extraction port.
4. liquid shifting equipment according to claim 3, wherein, the described pumping equipment shared comprises gear-type pump, is preferably ring gear pump.
5. liquid shifting equipment according to claim 1, wherein, described control module is controllable, is operatively connected described in alternatively and selectively setting up simultaneously.
6. according to the liquid shifting equipment one of claim 1 to 5 Suo Shu, wherein, described valve by adjustment make when by control from OFF to ON state or control with being reversed time spray or extract insignificant volume.
7. according to the liquid shifting equipment one of claim 1 to 6 Suo Shu, comprise flow sensor, this flow sensor is interconnected between the group of described transfer pipet and described pumping equipment.
8. a liquid handling device, this liquid handling device comprises according to the liquid shifting equipment one of claim 1 to 7 Suo Shu.
9. liquid handling device according to claim 8, comprises controlled location driver, and this controlled location driver controls the position of described liquid shifting equipment along at least two spatial coordinate axles.
10. liquid handling device according to claim 9, described controlled location driver, by separate mode, controls the position of described liquid shifting equipment and/or described at least two group transfer pipets along the 3rd spatial coordinate axle.
11. 1 kinds, for controlling the method for liquid shifting equipment or at least two liquid dosages for generation of predetermined, comprising:
First group of transfer pipet at least two group transfer pipets is immersed in the first reservoir containing first liquid, described first group of transfer pipet is operably connected on the extraction port on pumping equipment by gaseous conveying medium, and set up extraction effect in described extraction port
Open wide the ON/OFF valve in described gaseous conveying medium, be drawn into by first liquid in described first group of transfer pipet thus, wherein an ON/OFF valve is interconnected between described first group of transfer pipet and described extraction port;
Close the described ON/OFF valve in described gaseous conveying medium, wherein an ON/OFF valve is interconnected between described first group of transfer pipet and described extraction port;
Second group of transfer pipet in described at least two group transfer pipets is immersed in the second reservoir containing second liquid, described second group of transfer pipet is operably connected on the described extraction port on described pumping equipment by gaseous conveying medium, and set up extraction effect in described extraction port, thus second liquid is drawn in described second group of transfer pipet;
Open wide the 2nd ON/OFF valve in described gaseous conveying medium, be drawn into by second liquid in described second group of transfer pipet thus, wherein the 2nd ON/OFF valve is interconnected between described second group of transfer pipet and described extraction port;
Close the described 2nd ON/OFF valve in described gaseous conveying medium, the 2nd ON/OFF valve is interconnected between described second group of transfer pipet and described extraction port;
Thus, opened by the corresponding timing controlled of a described ON/OFF valve and the 2nd ON/OFF valve, to from being operatively connected described in described first group of transfer pipet and described second group of transfer pipet to described extraction port, to carry out timing multiplexed,
Described pumping equipment is controlled so as to operating during being operatively connected described in foundation always, and
By means of only the time span selecting described valve correspondingly to open wide period set up extract the volume of dosage.
12. methods according to claim 11, select at least one group of transfer pipet at least two group transfer pipets described in being included in, and make this at least one group of transfer pipet comprise an independent transfer pipet.
13., according to claim 11 to the method one of 12 described, comprise at least one item in following option:
Described first liquid and second liquid are different,
Described first reservoir and the second reservoir are two different containers,
With carrying out described immersion.
14., according to claim 11 to the method one of 13 described, also comprise other, selectable operator scheme, wherein, be operatively connected and side by side set up described in described first group of transfer pipet and second group of transfer pipet and described extraction port.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109152992A (en) * | 2016-05-23 | 2019-01-04 | 贝克顿·迪金森公司 | The liquid distributor of manifold mount with the liquid relief tube passage for modular independent actuation |
| CN109937365A (en) * | 2016-11-15 | 2019-06-25 | 天康瑞士股份公司 | Liquid relief method and liquid-transfering device |
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| US10451644B2 (en) | 2016-05-23 | 2019-10-22 | Becton, Dickinson And Company | Liquid dispenser with manifold mount for modular independently-actuated pipette channels |
| US10816566B2 (en) | 2016-05-23 | 2020-10-27 | Becton, Dickinson And Company | Liquid dispenser with manifold mount for modular independently-actuated pipette channels |
| US11099203B2 (en) | 2016-05-23 | 2021-08-24 | Becton, Dickinson And Company | Liquid dispenser with manifold mount for modular independently-actuated pipette channels |
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| CN115475542B (en) * | 2016-05-23 | 2023-04-07 | 贝克顿·迪金森公司 | Liquid dispenser with manifold mount for modular independently actuated pipette channels |
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