CN104274254B

CN104274254B - Animal venipuncture administration accurate quantification device

Info

Publication number: CN104274254B
Application number: CN201310283743.XA
Authority: CN
Inventors: 王薇; 宋红梅; 连冬梅
Original assignee: Peking Union Medical College Hospital Chinese Academy of Medical Sciences
Current assignee: Peking Union Medical College Hospital Chinese Academy of Medical Sciences
Priority date: 2013-07-08
Filing date: 2013-07-08
Publication date: 2016-06-01
Anticipated expiration: 2033-07-08
Also published as: CN104274254A

Abstract

The present invention provides a kind of animal venipuncture administration accurate quantification device, and described device comprises: needle portion, and it comprises syringe needle, protective sleeve of syringe needle, needle handle, syringe needle flexible pipe; With trident interface section, its main body is the trident flexible pipe with three ports, wherein the first port connects the first flexible pipe of trident flexible pipe, Two-port netwerk connects the 2nd flexible pipe of trident flexible pipe, 3rd port connects the 3rd flexible pipe of trident flexible pipe, first port is used for the syringe needle flexible pipe of connecting needle part, and Two-port netwerk and the 3rd port, for connecting syringe, the 2nd flexible pipe and the 3rd flexible pipe are provided with flow control pulley; And the syringe that two with a scale, for injecting liquid.

Description

Animal venipuncture administration accurate quantification device

Technical field

The present invention relates to a kind of animal venipuncture administration accurate quantification device.

Background technology

When carrying out experimentation on animals or to treatment of animals, often using venipuncture administration or get blood technology, usually used is disposable syringe (see accompanying drawing 1) directly administration or get blood. For smaller animal, such as rat, mouse tail edge vein, rabbit auricular vein etc., owing to blood vessel is tiny, it is higher that direct syringe carries out venipuncture technical difficulty, blood vessel often can be caused to be pricked or entry needle does not enter the situation of blood vessel, and this kind of situation is without any sign, following consequence can be caused: one, Drug leakage (not entering blood vessel), changes route of administration when continuing administration; Two, dosage mistake, causes experimental error; Three, precious drug waste; Four, some specific drugs can cause laboratory animal scrap (as rat tail edge intravenous injection Dx carry out nephropathy model modeling time, if medicine does not directly enter blood vessel and seepage phenomenon occur, rat tail can be caused to come off, cannot again pass through tail edge intravenous injection other drug, affect subsequent experimental to carry out) even affect the parallel property of whole experiment, cause the waste of animal data by the gross, it is necessary to again purchase animal by the gross and test, serious waste time and money. This kind of method entry needle is not easily fixed in addition, it is easy to come off, and infectious agent is understood pollution test stand and then affected operator safety.

Summary of the invention

For above problem, the present invention proposes a kind of animal venipuncture administration accurate quantification device, and described device comprises: needle portion, and it comprises syringe needle, protective sleeve of syringe needle, needle handle, syringe needle flexible pipe; With trident interface section, its main body is the trident flexible pipe with three ports, wherein the first port connects the first flexible pipe of trident flexible pipe, Two-port netwerk connects the 2nd flexible pipe of trident flexible pipe, 3rd port connects the 3rd flexible pipe of trident flexible pipe, first port is used for the syringe needle flexible pipe of connecting needle part, and Two-port netwerk and the 3rd port, for connecting syringe, the 2nd flexible pipe and the 3rd flexible pipe are provided with flow control pulley; And the syringe that two with a scale, for injecting liquid by Two-port netwerk and the 3rd port.

By above technical scheme, it is possible to accurately judge whether entry needle is positioned at Ink vessel transfusing and then determines whether continue to push away medicine; Syringe needle can be made to be easy to Ink vessel transfusing fix, make whole injection process safer; Experiment can be made more accurate by accurate quantification dosage, and avoid drug waste; Can avoiding drug leakage, warranty test medicine enters blood vessel completely.

According to hereafter by reference to the accompanying drawings to the detailed description of the specific embodiment of the invention, those skilled in the art will understand the above-mentioned of the present invention and other objects, advantage and feature more.

Accompanying drawing explanation

Some specific embodiments of the present invention are hereinafter described with reference to the accompanying drawings by way of example, and not by way of limitation in detail. Those skilled in the art should understand that, these accompanying drawings may not be drawn in proportion. In accompanying drawing:

Accompanying drawing 1 is with disposable syringe venipuncture administration schematic diagram in prior art;

Accompanying drawing 2 is the needle portion schematic diagram of animal venipuncture administration accurate quantification device of the present invention;

Accompanying drawing 3 is the trident interface section schematic diagram of animal venipuncture administration accurate quantification device of the present invention;

Accompanying drawing 4 is the syringe schematic diagram of animal venipuncture administration accurate quantification device of the present invention.

Embodiment

As shown in Figure 2-4, the device of the present invention is divided into following components: (1) needle portion, comprises syringe needle, protective sleeve of syringe needle, needle handle, and syringe needle flexible pipe (is similar to scalp acupuncture, but flexible pipe is shorter than scalp acupuncture). 2) trident interface section, its main body is three sections of flexible pipes that trident connects, and has A, B, C tri-ports. The A port being connected with the first flexible pipe is connected with the syringe needle flexible pipe coupling of needle portion. Second, third flexible pipe being connected with B, C port respectively has a flow control pulley. B, C two ports can be connected with syringe especially disposable syringe, and B, C port has seal cap for convenience detach in addition. (3) first, the second with a scale mated respectively with B, C end two disposable syringes. Range can be changed as required. All connection joints are press-in connection joint.

If needing to multiple medicine, it is possible to be designed to the interface (being called multi-fork interface in the present invention) of more multi-fork (being greater than 3 forks). This is used in single job in short period of time to inject multiple medicine to experimental animal. Can also be used for by the repeatedly administration of multiple prong simultaneously. If such as to be observed multiple medicine to the impact of experimental animal, needing repeatedly to experimental animal puncture in prior art, owing to the puncture timed interval is longer and wayward, this may cause final experimental data can there is deviation due to the puncture timed interval. And adopt the multi-fork Interface design of the present invention, only laboratory animal need to be carried out one-time puncture, the timed interval that avoiding problems repeatedly punctures causes, such that it is able to accurately control administration time or accurately draw blood. Preferably, in order to avoid blood coagulation blocking device, in device, to be added antithrombotics.

This device using method is as follows:

1, first syringe draws physiological saline, and evacuation of air is for subsequent use.

2, second syringe draws trial drug, and evacuation of air is for subsequent use.

3, the syringe needle flexible pipe of needle portion is connected with A port, open B port sealing cap, being connected with B port by first syringe (inside having physiological saline), keep C port sealing cap tight, the flow control pulley on second, third flexible pipe connect B, C two-port reaches maximum. First syringe is promoted to make physiological saline be full of whole trident interface and syringe needle flexible pipe, bubble-free in whole device.

4, the needle handle of hand-held needle part; remove needle protective cap; syringe needle is inserted animal vein; bend syringe needle flexible pipe or the pulley that B port is adjacent is shut; observe with or without blood back; there is blood back then to retain syringe needle at Ink vessel transfusing, then continue to find blood vessel to best position without blood back, then with the fixing flexible pipe of adhesive tape and syringe needle. (physiological saline can not cause injury of laboratory animal or affect trial drug dosage. )

5, C end seal cap is opened, second syringe (inside having trial drug) is connected with C end, close the pulley that B port is adjacent, open the pulley that C port is adjacent, push away the medicine (pushing away the capacity volume VC that the injection volume V required for injection volume V medicine=test theory manages+C end flexible pipe) of designated volume/dosage according to the scale of second syringe.

6, the adjacent pulley of C port is closed, open the pulley that B port is adjacent, first syringe physiological saline is promoted all to push away into animal blood vessels (pushing away the capacity volume V pin of the capacity volume VA+ syringe needle flexible pipe of the capacity volume VB+A end flexible pipe into physiological saline volume VNS=B end flexible pipe) by the medicine remained in flexible pipe according to the scale of first, the VNS of comparable Theoretical Calculation suitably more to be pushed away into some, to ensure that liquid all enters.

In order to handled easily, the flexible pipe of all ports can all be made as capacity is 0.1ml or 0.2ml, and can prepare different specifications according to animal size and drug dose.

Interchangeable, the needle portion of the present invention and three trouble interface sections can directly as one, when can reduce operation like this, the time of connecting needle part and three trouble interface sections, reduces the pollution that the interface of needle portion and trident interface section may cause owing to repeatedly patching simultaneously.

Interchangeable, the syringe needle of the needle portion of the present invention can make remaining needle, can stay the pin in animal body. Having operated rear enclosed syringe needle end, during subsequent operation, direct connecting needle end, need not puncture again every time.

Interchangeable, above trident interface section all can be replaced as multi-fork (prong number is greater than three) interface section.

By above technical scheme, simple to operate, can effectively avoid drug leakage, it is to increase the success ratio of animal experiment, reduce animal suffering, save plenty of time and money.

So far, those skilled in the art will recognize that, although the detailed multiple exemplary embodiment illustrate and describing the present invention herein, but, without departing from the spirit and scope of the present invention, still can directly determine according to content disclosed by the invention or derive other modification many or amendment of meeting the principle of the invention. Therefore, the scope of the present invention should be understood and regard as and cover all these other modification or amendments.

Claims

1. an animal venipuncture administration accurate quantification device, described device comprises: needle portion, and it comprises syringe needle, protective sleeve of syringe needle, needle handle, syringe needle flexible pipe; With trident interface section, its main body is the trident flexible pipe with three ports, wherein the first port connects the first flexible pipe of trident flexible pipe, Two-port netwerk connects the 2nd flexible pipe of trident flexible pipe, 3rd port connects the 3rd flexible pipe of trident flexible pipe, first port is used for the syringe needle flexible pipe of connecting needle part, and Two-port netwerk and the 3rd port, for connecting syringe, the 2nd flexible pipe and the 3rd flexible pipe are provided with flow control pulley; And two syringe first syringes with a scale and second syringe, for injecting liquid by Two-port netwerk and the 3rd port, it is characterised in that, this device operates in use as follows:

Step 1, first syringe draw physiological saline, and evacuation of air is for subsequent use;

Step 2, second syringe draw trial drug, and evacuation of air is for subsequent use;

The syringe needle flexible pipe of step 3, needle portion is connected with the first port, open Two-port netwerk seal cap, first syringe is connected with Two-port netwerk, keep the 3rd port sealing cap tight, the flow control pulley on second, third flexible pipe second, third two-port connected reaches maximum, promote first syringe to make physiological saline be full of whole trident interface section and syringe needle flexible pipe, make bubble-free in whole device;

The needle handle of step 4, hand-held needle part, remove needle protective cap, syringe needle is inserted animal vein, bend syringe needle flexible pipe or the flow control pulley that Two-port netwerk is adjacent is shut, observe with or without blood back, there is blood back then to retain syringe needle at Ink vessel transfusing, then continue to find blood vessel to best position without blood back, then with adhesive tape fixed needle flexible pipe and syringe needle;

Step 5, open the 3rd port sealing cap, second syringe is connected with the 3rd port, close the flow control pulley that Two-port netwerk is adjacent, open the flow control pulley that the 3rd port is adjacent, scale according to second syringe pushes away into medicine, wherein pushes away and manages the capacity volume VC of the+the three flexible pipe into injection volume V medicine=required injection volume V;

The pulley that step 6, closedown the 3rd port are adjacent, open the flow control pulley that Two-port netwerk is adjacent, first syringe is promoted according to the scale of first syringe, with physiological saline, the medicine remained in flexible pipe is all pushed away into animal blood vessels, push away the capacity volume V pin of the capacity volume VA+ syringe needle flexible pipe of capacity volume VB+ first flexible pipe into physiological saline volume VNS=the 2nd flexible pipe.