CN104224853A - Cream composition capable of strengthening glucosamine absorption effect - Google Patents
Cream composition capable of strengthening glucosamine absorption effect Download PDFInfo
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- CN104224853A CN104224853A CN201310251241.9A CN201310251241A CN104224853A CN 104224853 A CN104224853 A CN 104224853A CN 201310251241 A CN201310251241 A CN 201310251241A CN 104224853 A CN104224853 A CN 104224853A
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- assimilation effect
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Abstract
The invention relates to a cream composition capable of strengthening a glucosamine absorption effect. The cream composition is mainly prepared from the following components: at least 10-15wt% of glucosamine HCL, a methyl sulphide component, a chondroitin component and a cream substrate. The composition, by virtue of synergistic interaction of the components, is used for promoting the glucosamine component to permeate from the affected skin so as to achieve the purpose of strengthening the absorption effect of a human body.
Description
Technical field
The present invention is relevant with the cream compositions containing glucamine, and in more detail, being that finger is a kind of can strengthen glucamine assimilation effect by the synergism of compositions to reach.
Background technology
In recent years osteoarthritis, the generation age constantly declines, and it is often apt to occur in the knee endoprosthesis place of patient.And oral glucose amine (Glucosamine) confirms the articular cartilage hypertrophy that can promote patient through experiment in recent years, the malaise symptoms such as arthralgia can be improved.But only less than 1% act on affected tissue in oral dose.Therefore glucamine (Glucosamine) has the demand beyond peroral dosage form, active ingredient is acted directly on target joint, is the maximum target will made great efforts at present.
Can absorb through skin based on active ingredient in medicine place system (Drug Del ivery System, DDS) ointment, therefore cream product also can utilize its characteristic, and skin forms protective layer, promotes active ingredient to absorb and utilizes.Because cream is that aqueous phase and oil phase are dispersed with emulsifying agent, but traditional cream has glutinous greasy, thick and heavy sense, user is allowed not like using subjective, add general glucosamine HCL (Glucosamine HCL) cream content comparatively Gao Shiyi have not easily homogenizing, the situation even producing the unfavorable preservations such as water decomposition occurs, therefore general glucosamine HCL (Glucosamine HCL) content of cream is only between 5-10%, and there are no the composition that strengthening absorbs.
Summary of the invention
In order to improve above-mentioned shortcoming, the invention provides the cream compositions of a kind of tool strengthening glucamine assimilation effect, it has done the improved formulations of following glucamine cream compositions (Glucosamine Cream), for added aqueous or oil components, because after emulsifying " particle diameter diminishes; absorbance increases ", add absorption enhancer (enhancer) again, carrier (carrier) ... etc., more can improve through skin absorptance, to reach the object of strengthening glucamine assimilation effect.
The present invention is the cream compositions of a kind of tool strengthening glucamine assimilation effect, and it consists predominantly of:
The glucosamine HCL (Glucosamine HCL) of at least 10% 15% percentage by weight at the most;
Monomethyl sulfide composition;
One chrondroitin composition; And
One cream substrate;
Said composition interacts synergistically by its composition, to promote that glucamine composition penetrates into from pars affecta skin, to reach the object of body assimilation effect.
Wherein, this methyl sulfide composition is 1% ~ 5% percentage by weight, and chrondroitin composition is 1% ~ 5% percentage by weight.
Wherein, this cream substrate more comprises micromolecule hyaluronic acid (HA) composition.
Wherein, the molecular weight of this micromolecule hyaluronic acid (HA) is 5000-6000, and its percentage by weight is 0.1% ~ 1%.
Wherein, this chrondroitin is made by shark cartilage.
Wherein, this cream substrate more comprises seaweed extract thing (Oligogeline) composition, and its percentage by weight is 1% ~ 10%.
Wherein, this cream substrate more comprises an absorption enhancer composition, and its percentage by weight is 1% ~ 36%.
Wherein, this absorption enhancer composition can be isosorbide dimethyl ether (Dimethyl Isosorbide (DMI)).
Wherein, this cream substrate more comprises a blood circulation accelerant composition, and its percentage by weight is 0.1% ~ 1%.
Wherein, blood circulation accelerant composition can be Mentholum (Methanol), chilli extract (Capsicum Frutescens).
By above-mentioned: the present invention is according to DDS principle, the use amount of active ingredient is larger, the amount absorbed through skin is also more, and the content of general glucosamine HCL cream is all between 5-10%, in order to improve in cream glucosamine HCL content to 10%-15%, the difficulty on many Making programme is had to need to overcome (supersaturation cannot improve content), and we according to this formula make glucosamine HCL cream, the glucosamine HCL containing 10%-15% percentage by weight is the product that current content is maximum.
By above-mentioned: compositions of the present invention can directly be applied in pars affecta skin place, after the Absorption of pars affecta skin, interact synergistically and promote to generate cartilaginous tissue and joint tissue liquid by its composition glucosamine HCL, methyl sulfide, chrondroitin, to reach the object for the treatment of osteoarthritis.And be added with the compositions such as micromolecule hyaluronic acid (HA), seaweed extract thing (Oligogel ine), absorption enhancer and blood circulation accelerant further, except the percutaneous absorbtion effect that can promote glucamine, have more the effect suppressing affected part inflammation and pain of releiving.
By above-mentioned: mostly use Polyethylene Glycol PEG to use as wetting agent in vague generalization cosmetic or cream constituent, but in recent years because Polyethylene Glycol PEG is confirmed as carcinogen by U.S. FDA, therefore formula of the present invention uses not containing the composition of Polyethylene Glycol (PEG FREE) further, uses for doubt that is healthy and safety to reduce user.
Accompanying drawing explanation
Fig. 1: be dermal absorption experiment permeation data figure of the present invention.
Detailed description of the invention
The present invention is the cream compositions of a kind of tool strengthening glucamine assimilation effect, and it consists predominantly of:
A) a cream substrate;
B) glucosamine HCL (Glucosamine HCL) of at least 10%-15% percentage by weight:
According to DDS principle, the use amount of active ingredient is larger, the amount absorbed through skin is also more, and the content of general glucosamine HCL cream is all below 10%, to 10%-15%, the difficulty on many Making programme is had to need to overcome (supersaturation cannot improve content) to improve glucosamine HCL content in cream, and the glucosamine HCL cream that we make, glucosamine HCL containing at least 10% to 15% percentage by weight is the product that current content is maximum.
C) monomethyl sulfide composition:
Human body has many tissues as hair, skin, fingernail ... Deng there being methyl sulfide MSM, its molecular weight is 94, easy absorbing transmission from skin.
D) a chrondroitin composition:
According to research display, utilize shark cartilage, have the arthritis (morphotropism joint disease) of 70%, the chronic joint rheumatalgia of 60% alleviates, not worse than medication effect.Shark cartilage so effective to chronic joint rheumatism, namely just by its in anti-angiogenesis protein, the blood capillary of cartilage can be eliminated, and mucopolysaccharide body can suppress inflammation symptom to cause.And in shark cartilage, be more rich in abundant natural mineral matter " calcium " and " phosphorus " ... Deng, fully can supplement the nutrient in skeleton and joint.
Compositions of the present invention can directly be applied in pars affecta skin place, after the Absorption of pars affecta skin, interact synergistically and promote to generate cartilaginous tissue and joint tissue liquid by its composition glucosamine HCL, methyl sulfide, chrondroitin, to reach the object for the treatment of osteoarthritis.
Wherein, this hyaluronic acid (HA) composition is 0.1% ~ 0.5% percentage by weight, and methyl sulfide composition is 1% ~ 5% percentage by weight, and chrondroitin composition is 1% ~ 5% percentage by weight.
Moreover, more can comprise in this cream substrate:
E) micromolecule hyaluronic acid (HA) composition:
Micromolecule hyaluronic acid (HA) mean molecule quantity is 5000-6000, its molecular size is about 25 how rice, directly can pass horn cell gap, to be absorbed via sweat gland, intercellular substance, pore, micromolecule hyaluronic acid not only has moisturizing, reduce wrinkle ... etc. the characteristic of general traditional sub-Q, also have antiallergic, antioxidative effect, its percentage by weight is 0.1% ~ 1%.
F) seaweed extract thing (Oligogeline) composition:
It is a kind of seaweed extract thing from ocean, has the characteristic of repairing skin, is also called ocean binder, the uniform ingredients such as cream substrate can be allowed in the product to disperse, and be fixed on pars affecta skin place, increase the effect of the absorption of active ingredient, its percentage by weight is 1% ~ 5%.
G) an absorption enhancer composition:
It is a kind of not second to medicinal organic solvent that this absorption enhancer composition can be isosorbide dimethyl ether Dimethyl Isosorbide (DMI), active ingredient can be made dispersed, allow absorbance promote.Its percentage by weight is 1% ~ 36%.
H) a blood circulation accelerant composition:
This blood circulation accelerant composition system can be Mentholum, chilli extract Capsicum Frutescens.Mentholum Methanol, chilli extract Capsicum Frutescens can help blood circulation, enhance metabolism, and increase the absorption of active ingredient, and the taste that product can be provided pure and fresh, refrigerant sensation, the sensation of slow affected part discomfort of relaxing can be improved.Mentholum Methanol, its percentage by weight of chilli extract Capsicum Frutescens are 0.1% ~ 1.0%.
Based on above recipe design, the present invention directly can be applied in affected part articular skin place, the composition needed for absorbing transmission from skin cartilage proliferation.Allow these compositions after skin absorbs, can affected tissue be acted directly on, improve the symptom of target joint, tool strengthening glucamine assimilation effect.
For checking, the present invention has aforesaid various effect really, and applicant has carried out the following cream compositions assimilation effect experimental design containing glucamine further, and committee carries out experiment test by the medical science unit of third party's tool public credibility.
One, executable unit: horse innovates Incubation Center together with memorial hospital
Two, executor: horse is together with the village, medical research portion of memorial hospital will light technical manager
Three, experimental design, the process of nude mice cortex:
The cortex that the cortex that this research uses is nude mice back, after cortex cuts down from animal body, with scalpel, the Musclar layer on cortex is removed, then remove oils and fats above cortex and dirt with the diluted mild detergent of saline solution, finally cut into about 2cmx2cm size with normal saline solution cleaning 3 ~ 5 times.
Four, percutaneous absorbtion test:
All samples, all through six repeated trials, utilizes rectilinear in-vitro percutaneous absorption apparatus (Franz cell) test formulations under room temperature whether to transmit glucosamine and penetrates cortex.Rectilinear Franz cell is upper and lower two parts glass structure, the first half is medicine-carrying trough, Lower Half is dump tank, before sandwiching test cortex, dump tank first need fill normal saline solution and put a miniature rotor, then cortex is tiled after on it, medicine-carrying trough on frame is also fixed with metal clip, finally the formula 2ml of test is added medicine-carrying trough and with parafilm sealing after, Franz cell is placed on magnetic stirrer and continues to rotate miniature rotor, and in setting time point (0,2,4,6,24hr) take out the sample of 50ul in dump tank from probe tube.
Five, experimental group and matched group:
Following table one is this case first Example formulations composition table, and wherein A group is matched group.Table two is this case second Example formulations composition table, and wherein D group is matched group.
[table one] the first Example formulations composition table
[table two] the second Example formulations composition table
Six, sample analysis:
From the sample 50ul that the dump tank of percutaneous absorbtion instrument takes out, first after centrifugal 30 minutes with 12000rpm, get supernatant and insert in the special analyzer tube of liquid chromatography (LC) tandem mass spectrometer.The operating condition of liquid chromatography (LC) tandem mass spectrometer is as follows: being separated tubing string is Luna silica100A (2x50mm, 5um), and mobile phase A is 0.01% formic acid (formic acid), and Mobile phase B is 1mM NH
4oAc+0.1% formic acid, in 100% acetonitrile (acetonitrile), draws gradient to rush and puies forward situation as table three.Main signal punching carry the time be about 2.3 minutes time occur, area under signal draws numerical value D (ng/ml) via contrasting with standard curve after integration, permeates cortex gross area F (cm via formula D (ng/ml) × dump tank volume V (ml) ÷
2) converting draws the permeability P (ng/cm of sample
2).
Table three: liquid chromatography (LC) tandem mass spectrometer operating condition
Seven, result
Learn from analytical data, A, D colloid is not containing glucamine (table four).From the trend (Fig. 1) of infiltration in six hours, E penetrates cortex effect and preferably reaches 180ug/cm
2, B, F, G then hardly differ about 50 ~ 60ug/cm
2, and the transdermal effect of C is the poorest.24 hours permeation data (Fig. 1), E, F reached 300ug/cm
2above, G is close to 100ug/cm
2, B is close to 60ug/cm
2.
The percutaneous absorbtion data of table four: A-G seven kinds of formula, wherein, A and D containing glucamine, is not therefore shown in table.AVE: average (ng/cm
2), SE: standard error.
Can be learnt by the above results, and even cream composite formula of the present invention is after 2 hours, 4 hours, 6 hours 24 hours, all can effectively promotes glucamine assimilation effect, there is effect really that reach the object of the invention.
Claims (10)
1. a cream compositions for tool strengthening glucamine assimilation effect, it consists predominantly of:
The glucosamine HCL (Glucosamine HCL) of at least 10% to 15% percentage by weight;
Monomethyl sulfide composition;
One chrondroitin composition; And
One cream substrate;
Said composition interacts synergistically by its composition, to promote that glucamine composition penetrates into from pars affecta skin, to reach the object of body assimilation effect.
2. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 1, it is characterized in that, this methyl sulfide composition is 1% ~ 5% percentage by weight, and chrondroitin composition is 1% ~ 5% percentage by weight.
3. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 1, it is characterized in that, this cream substrate more comprises micromolecule hyaluronic acid (HA) composition.
4. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 1, it is characterized in that, the molecular weight of this micromolecule hyaluronic acid (HA) is 5000-6000, and its percentage by weight is 0.1% ~ 1%.
5. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 1, it is characterized in that, this chrondroitin is made by shark cartilage.
6. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 1, it is characterized in that, this cream substrate more comprises seaweed extract thing (Oligogeline) composition, and its percentage by weight is 1% ~ 10%.
7. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 1, it is characterized in that, this cream substrate more comprises an absorption enhancer composition, and its percentage by weight is 1% ~ 36%.
8. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 7, it is characterized in that, this absorption enhancer composition can be isosorbide dimethyl ether (Dimethyl Isosorbide (DMI)).
9. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 1, it is characterized in that, this cream substrate more comprises a blood circulation accelerant composition, and its percentage by weight is 0.1% ~ 1%.
10. the cream compositions of tool strengthening glucamine assimilation effect as claimed in claim 9, it is characterized in that, blood circulation accelerant composition can be Mentholum (Methanol), chilli extract (Capsicum Frutescens).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310251241.9A CN104224853A (en) | 2013-06-24 | 2013-06-24 | Cream composition capable of strengthening glucosamine absorption effect |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310251241.9A CN104224853A (en) | 2013-06-24 | 2013-06-24 | Cream composition capable of strengthening glucosamine absorption effect |
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| CN104224853A true CN104224853A (en) | 2014-12-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113304186A (en) * | 2021-05-26 | 2021-08-27 | 上海橙果生物工程有限公司 | Skin cream capable of relieving joint pain and improving joint vitality as well as preparation method and using method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010011083A1 (en) * | 1999-09-29 | 2001-08-02 | Barr Teresa Leigh | Pain reliever and method of use |
| US6579543B1 (en) * | 2002-02-22 | 2003-06-17 | Jackie H. McClung | Composition for topical application to skin |
| CN101505719A (en) * | 2006-08-25 | 2009-08-12 | 兴和株式会社 | Emulsion composition giving good feeling in use |
-
2013
- 2013-06-24 CN CN201310251241.9A patent/CN104224853A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010011083A1 (en) * | 1999-09-29 | 2001-08-02 | Barr Teresa Leigh | Pain reliever and method of use |
| US6579543B1 (en) * | 2002-02-22 | 2003-06-17 | Jackie H. McClung | Composition for topical application to skin |
| CN101505719A (en) * | 2006-08-25 | 2009-08-12 | 兴和株式会社 | Emulsion composition giving good feeling in use |
Non-Patent Citations (1)
| Title |
|---|
| AMAZON: "Natures Plus Glucosamine Chondroitin & MSM Joint Cream 118ml Tube", 《HTTPS://WWW.AMAZON.CO.UK/NATURES-PLUS-GLUCOSAMINE-CHONDROITIN-JOINT/DP/B002FJW1II》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113304186A (en) * | 2021-05-26 | 2021-08-27 | 上海橙果生物工程有限公司 | Skin cream capable of relieving joint pain and improving joint vitality as well as preparation method and using method thereof |
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Application publication date: 20141224 |
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| RJ01 | Rejection of invention patent application after publication |