CN104127262B - Astigmatism correction type artificial intraocular lenses and design thereof and production method - Google Patents
Astigmatism correction type artificial intraocular lenses and design thereof and production method Download PDFInfo
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- CN104127262B CN104127262B CN201310610150.XA CN201310610150A CN104127262B CN 104127262 B CN104127262 B CN 104127262B CN 201310610150 A CN201310610150 A CN 201310610150A CN 104127262 B CN104127262 B CN 104127262B
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- intraocular lenses
- artificial intraocular
- optic
- type artificial
- astigmatism correction
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- 201000009310 astigmatism Diseases 0.000 title claims abstract description 85
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 238000000034 method Methods 0.000 claims description 18
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000000017 hydrogel Substances 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000003044 adaptive effect Effects 0.000 abstract description 15
- 239000013078 crystal Substances 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 10
- 230000006978 adaptation Effects 0.000 abstract description 4
- 230000002459 sustained effect Effects 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 3
- 210000001508 eye Anatomy 0.000 description 10
- 230000006835 compression Effects 0.000 description 7
- 238000007906 compression Methods 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 230000007704 transition Effects 0.000 description 4
- 238000009499 grossing Methods 0.000 description 3
- 230000012447 hatching Effects 0.000 description 3
- 201000009308 regular astigmatism Diseases 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000002153 concerted effect Effects 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 101100377706 Escherichia phage T5 A2.2 gene Proteins 0.000 description 1
- 208000029091 Refraction disease Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004430 ametropia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000036040 emmetropia Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 201000000766 irregular astigmatism Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 208000014733 refractive error Diseases 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
Abstract
The present invention relates to astigmatism correction type artificial intraocular lenses and design thereof and production method.A kind of Toric artificial intraocular lenses of optic outer rim uniform thickness, the design of Adaptive matching flange is used at the outer rim of Toric artificial intraocular lenses effective light school district, Toric crystal is made to be thickened to sustained height by the outside self adaptation of different-thickness of outer rim all angles position, effective light school district, thus ensure toric intraocular lens optic portion outer rim uniform thickness, improve toric artificial intraocular lenses positional stability in pouch, and then the long-term astigmatism correction effect of raising toric artificial intraocular lenses, and release the restriction of button loop Position Design.
Description
Technical field
The invention mainly relates to astigmatism correction type artificial intraocular lenses.Specifically, the present invention relates to a kind of optic outer rim thick
Spend the equal Toric artificial intraocular lenses being used for correcting astigmatism and design thereof and production method.
Background technology
Artificial intraocular lenses (IOL) is a kind of artificial lens that can implant ophthalmic.As it is shown in figure 1, the form of artificial intraocular lenses 1, logical
Often it is made up of with the support button loop 5 being arranged on optic 2 periphery a circular light department of the Chinese Academy of Sciences 2.The optic 2 of artificial intraocular lenses 1 is by having
Effect light school district 3 and optic edge part 4 are constituted.
Ametropia is factor significantly a kind of on image quality impact, wherein astigmatism be a kind of common people's refraction of eye not
Positive phenomenon, refers to that eyeball refractive power on different warps is inconsistent, or the diopter of same warp, so that entering the flat of ophthalmic
Row light can not form focus on the retina, and forms the phenomenon of focal line.Astigmatism is clinically divided into regular astigmatism and does not advises
Then astigmatism two kinds.Two warps of refractive power difference maximum are main radial line, and two main warp lines are mutually perpendicular to, for regular astigmatism；Respectively
Meridianal astigmatism flexibility is inconsistent, for irregular astigmatism.Wherein regular astigmatism can be corrected by eyeglass.
In normal population, corneal astigmatism accounts for 15%-29% more than 1.5D's, has a strong impact on the visual quality of people.At present
The up-to-date Therapeutic Method of cataract of companion's astigmatism is to reach by implanting an astigmatism type artificial intraocular lenses (Toric IOL) within the eye
The purpose of corneal astigmatism is corrected while emmetropia.
The development of Toric artificial intraocular lenses is initially to be proposed by the Kimiya Shimizu of Japan, and U.S. FDA was in 1998
Formally examining by being applied to clinic, the most each big artificial crystal production manufacturer has all released one after another oneself Toric people
Work crystal.These Toric artificial intraocular lensess have single type, also have three-member type；Have soft, rigid；Material have hydrophilic,
Hydrophobic；Combine aspheric surface, multifocal, the most also can use modified model " L " button loop or " C " button loop, improve Toric artificial
Crystal stability in human eye.No matter which kind of design, it is achieved the technological core of the Toric artificial intraocular lenses of astigmatism correction is by light
Toroid (toroidal) in the shape of face is applied to artificial intraocular lenses, artificial intraocular lenses original dioptric on the basis of extra-column mirror
Degree, utilizes the toroid feature that diopter is inconsistent on each warp direction, corrects the astigmatism of cataract patient cornea.
The definition in Toric face shape (toroid) is known for those skilled in the art, it may be assumed that Y-Z plane
In curve l(bus) be perpendicular to the straight line l ' (rotary shaft) of Z axis around Y-axis and rotate a circle to form and (see Zemax
Optical Design Program Users Guide page 272, Toroidal part).Curve l can be round, it is possible to
To be aspheric curve, the distance of l ' to the bus center of circle is rotary shaft radius, as shown in Figure 2 (the figure of toric acquisition principle
Solve explanation).
No matter bus is spherical curve or is aspheric curve, and by the derivation of equation, (respective formula can be in optics work
Tool book, such as Daniel Malacara, Handbook of optical design, chapter 2, formula A2.2 and formula A2.5
(see annex)) and Theoretical Calculation would know that: for toric artificial intraocular lenses, it is determined that the curvature in primary mirror and post mirror direction half
The center thickness (or the edge thickness in primary mirror direction) of footpath and artificial intraocular lenses, then at each point of intraocular lens optic portion outer rim
Thickness all determines that.
Fig. 3 shows the situation of change of Toric artificial intraocular lenses radius of curvature under different angles and thickness.For
For toric artificial intraocular lenses, on Radius in office, (such as Fig. 3 radius r), eyeglass is in each radius of curvature in the radial direction not
With, thickness is different, as it is shown on figure 3, the maximum (R of primary mirror directional curvature radius0), the thickest (d simultaneously0), post mirror directional curvature radius is
Little (R90), the thinnest (d simultaneously90), the radius of curvature in remaining direction and thickness are in therebetween, gradually transition change.Accordingly
Ground, the thickness of Toric intraocular lens optic portion outer rim also complies with this rule, i.e. became uneven, the thickest with primary mirror direction, post mirror
Direction is the thinnest, and on remaining direction, thickness is in therebetween.The most such as, Fig. 4 shows that refractive index is 1.48, diopter 20D, post
Mirror degree 1.5D, the thickness d (unit is millimeter) of the toric intraocular lens optic portion outer rim of primary mirror direction thickness 0.3mm is with circumference position
Angle setting degree A(unit be degree) change curve.Derived by simple Theoretical Calculation and just can find and as shown in Figure 4: toric
The thickness distribution circumferentially thickness of intraocular lens optic portion outer rim meets sin/cos curve distribution rule.
But, the phenomenon of the circumferentially became uneven of this optic outer rim is brought to toric artificial intraocular lenses and be asked as follows
Topic:
(1) make Toric artificial intraocular lenses all directions unbalance stress in human eye pouch, cause Toric artificial intraocular lenses to rotate
Off normal, affects astigmatism correction effect.
After artificial intraocular lenses puts into human eye pouch 9, pouch supports button loop 5 applying pressure to artificial intraocular lenses, and artificial intraocular lenses accordingly can
Produce counteracting force, maintain artificial intraocular lenses position in pouch stable.Toric artificial intraocular lenses force analysis in pouch is shown in
Fig. 5.Pouch 9 supports button loop by compression, and intraocular lens optic portion 2 is applied compression stress F, and this power can be analyzed in all directions
Component, is such as decomposed into power F on the thinnest direction of Toric artificial intraocular lensestPower F on the thickest directioni, as shown in Figure 5
(F1t, F2t；And F1i, F2i)；Toric artificial crystal material produces reaction tension force f to the compression stress of pouchiWith ft, in Fig. 5
Shown (f1t, f2t；And f1i, f2i), due to Toric artificial intraocular lenses marginal portion became uneven, cause the support force f in thin directiontBecome
Little, the pressure that pouch applies can not be completely counterbalanced by two thin directions, and what Toric artificial intraocular lenses produced in all directions makes a concerted effort
F all differs in size with direction with compression stress F of pouch, and the power that the two is not offset forms Toric artificial intraocular lenses circle
The revolving force of circumferential direction, causes Toric artificial intraocular lenses to rotate.
Astigmatism correction type artificial intraocular lenses has strict requirements, clinical practice to crystal astigmatism axle and corneal astigmatism shaft alignement
Showing, implanting Toric artificial intraocular lenses, Toric artificial intraocular lenses often rotates 1 °, the lens cylinder mirror degree of 3.3% can be caused to lose, Toric
Artificial intraocular lenses rotates ＞ 30 ° or more, can cause the complete failure of astigmatism correction, the therefore this circumference of Toric artificial intraocular lenses
Astigmatism correction can be produced and have a strong impact on by the rotation in direction.And the pouch effect that this optic outer rim became uneven is caused
The Toric artificial intraocular lenses that power inequality causes rotates and accumulates over a long period, can be along with the increase of Toric Intraocular implantation time
Do not stop accumulation to increase the weight of.
(2) being limited by button loop support force, the button loop of artificial intraocular lenses needs to ensure certain thickness.But, Toric is the most brilliant
The Position Design of button loop is formed and limits by body, and the phenomenon of brim-portion thickness inequality makes Toric artificial intraocular lenses button loop design to be existed
The thickest direction of outer rim, Toric intraocular lens optic portion, to ensure enough thickness and enough support forces, thus limit doctor
Selection with patient.
Summary of the invention
The present invention proposes in view of the above problems, its object is to the Toric providing the outer edge thickness of a kind of optic equal
Artificial intraocular lenses, to improving Toric artificial intraocular lenses positional stability in pouch, and then improves the length of toric artificial intraocular lenses
Phase astigmatism correction effect, and release the restriction of button loop Position Design.
Term defines
The term " optic " used in this application refers to the effective light school district by artificial intraocular lenses and light around thereof
The optical lens rounded for longitudinal center section 8-8 ' that department of the Chinese Academy of Sciences marginal portion is constituted is (such as reference 2 institute in Fig. 1, Fig. 6
Show).
What the term " effective light school district " used in this application referred to be positioned at center, intraocular lens optic portion has light
Learn characteristic it is thus possible to realize the part of the major function of regulation artificial intraocular lenses's diopter and/or rectification astigmatism.Specifically, originally
The diameter of the optic of the toric artificial intraocular lenses used in inventive embodiments is about 6 millimeters (maximum up to 6.5 millimeters), its
In effectively light school district refer to the circular portion being positioned within the optic edge part of toric artificial intraocular lenses, its diameter is more than
Equal to 4.25 millimeters.
The term " optic edge part " used in this application refers to be arranged on the effective light in intraocular lens optic portion
The annular edge region of the optical characteristics not interfering with artificial intraocular lenses that school district is peripheral.
The term " effective light school district outer rim " used in this application refers to the longitudinal center section 8-for optic
For 8 ' rounded artificial intraocular lensess, with the vertical section of circle effective light school district perimeter edge in the optics of optic
Distance between the vertical section O'-O'' of heart O is the radius circumferential position such as grade in the intraocular lens optic portion that radius limits,
See Figure of description Fig. 6.
The term " optic outer rim " used in this application refers to the longitudinal center's circular cross section for optic
Artificial intraocular lenses for, with vertical section vertically the cutting to the optical center O through optic of circular light department of the Chinese Academy of Sciences perimeter edge
Distance between the O'-O'' of face is the radius circumferential position such as grade in the intraocular lens optic portion that radius limits.
The term " anterior optic surface " used in this application refers to by tailing edge eye in Intraocular implantation human eye
Direction of principal axis distance eye cornea closer to that optic surface.
The term " optic rear surface " used in this application refer in artificial intraocular lenses with above-mentioned optic before table
That optic surface that face is relative.
The term used in this application " is fastened with a rope, string, etc. " and is referred to be connected with intraocular lens optic portion, both played support optic
The part of the effect that contractility produced by the contraction of ciliary muscle and varicose is delivered to described optic is played again in effect.
Being used the term such as " convex " representing shape in this application, " recessed " is indulging relative to intraocular lens optic portion
For central plane 8-8 '.
For the Toric artificial intraocular lenses in the application, term " anterior optic surface summit " used herein
Refer to the central point in the anterior optic surface of described artificial intraocular lenses.It may also be said that anterior optic surface summit refers to: institute
State the distance in the anterior optic surface of artificial intraocular lenses and between the longitudinal median plane of this IOL optic Portion farthest
Point (sees reference O' in Fig. 7)；Term " summit, optic rear surface " used herein refer to described manually
Central point on the optic rear surface of crystal.It may also be said that summit, optic rear surface refers to: the light of described artificial intraocular lenses
Distance point furthest on department of the Chinese Academy of Sciences rear surface and between the longitudinal median plane of this IOL optic Portion (sees in Fig. 7
Reference O'').
Term " effective light school district bus " used herein refer to according to the above toric define into
Row moves and produces the curve on surface, effective light school district.
Term " flange curve " used herein refers in optic edge part and specific effectively optics
The curve extending to optic outer rim from effective optics district outer rim that district's bus is corresponding.
Term " design of Adaptive matching flange " used herein refers to make effective light school district bus relative with it
The design that the flange curve smoothing answered connects, i.e. the cutting of effective light school district bus and its corresponding flange curve at junction point
The design that line coincides.
Specifically, the present invention relates to the content of following many aspects:
1. an astigmatism correction type artificial intraocular lenses, described astigmatism correction type artificial intraocular lenses includes:
The optic being made up of effective light school district and optic edge part；
The button loop being connected with described optic at optic outer rim,
The diameter of wherein said effective light school district is more than or equal to 4.25 millimeters and described effective light school district uses toroid to set
Meter；
It is characterized in that,
Equal and described optic outer rim the thickness of the thickness of the optic outer rim of described astigmatism correction type artificial intraocular lenses is
0.25mm-0.45mm。
2. according to the astigmatism correction type artificial intraocular lenses described in aspect 1, it is characterised in that described optic circular in shape.
3. according to the astigmatism correction type artificial intraocular lenses described in aspect 1 or 2, it is characterised in that the thickness of described optic outer rim
Degree is 0.25mm-0.38mm.
4. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned aspect 1-3, it is characterised in that described in have
The diameter of effect light school district is more than or equal to 5.00 millimeters.
5. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned aspect 1-4, it is characterised in that described scattered
The anterior optic surface of light rectification type artificial intraocular lenses and the face shape of rear surface include that the refraction of sphere, aspheric surface, toroid, multi-region sets
One or more in the face shape of the multi-focal-plane of meter and the multi-focal-plane of multi-region diffractive designs, and described astigmatism correction type artificial intraocular lenses
Anterior optic surface and rear surface at least one surface comprise toroid design.
6. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned aspect 1-5, it is characterised in that described light
The department of the Chinese Academy of Sciences designs part for flange in marginal portion.
7. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned aspect 1-6, it is characterised in that described scattered
Effective light school district bus of light rectification type artificial intraocular lenses is connected with the flange curve in its corresponding described flange design part.
8. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned aspect 1-7, it is characterised in that described scattered
Flange curve smoothing in effective light school district bus of light rectification type artificial intraocular lenses and its corresponding described flange design part
Connect.
9. the astigmatism correction type artificial intraocular lenses according to aforementioned aspect 1-6, according to any one of 8, it is characterised in that described
Flange curve is the circular arc with same curvature radius.
10. according to the astigmatism correction type artificial intraocular lenses described in aspect 9, it is characterised in that described flange song curvature of a curve half
Footpath scope is 0mm-2.4mm.
11. according to aforementioned aspect 1-6, the astigmatism correction type artificial intraocular lenses according to any one of 8, it is characterised in that described
Flange curve is the circular arc with different curvature radius.
12. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned aspect 1-11, it is characterised in that described
Astigmatism correction type artificial intraocular lenses is single type artificial intraocular lenses or three-member type artificial intraocular lenses.
13. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned aspect 1-12, it is characterised in that described
Astigmatism correction type artificial intraocular lenses is by refractive index silica gel, hydrogel, hydrophobic acrylic acid's ester or poly-first between 1.45 to 1.56
Base acrylic acid methyl ester. is made.
14. 1 kinds are designed the astigmatism correction type equal according to the outer edge thickness of the optic according to any one of aspect 8-13
The method of artificial intraocular lenses, said method comprising the steps of:
Set diameter and the thickness of described optic outer rim；
Set the link position of described effective light school district bus and its corresponding flange curve；And
Set the radius of curvature of described flange curve, so that described effective light school district bus is at described link position
Tangent line flange curve near tangent corresponding thereto coincide.
15. according to the method described in aspect 14, it is characterised in that described link position is positioned at the outer rim of effective light school district
And described flange curve has different radius of curvature.
16. according to the method described in aspect 14, it is characterised in that described link position is positioned at different-diameter in optic
Circumference on and described flange curve there is identical radius of curvature.
17. 1 kinds use according to the method for designing according to any one of aforementioned aspect 14-16, produce optic outer rim thick
The method spending equal astigmatism correction type artificial intraocular lenses.
The present invention has the advantages that especially
The present invention proposes the Toric artificial intraocular lenses of a kind of optic outer rim uniform thickness, in Toric artificial intraocular lenses effective light school district
Use the design of Adaptive matching flange at outer rim, make Toric crystal by the difference of outer rim all angles position, effective light school district
The outside self adaptation of thickness thickens to sustained height, thus ensures toric intraocular lens optic portion outer rim uniform thickness, improves toric people
Work crystal positional stability in pouch, and then improve the long-term astigmatism correction effect of toric artificial intraocular lenses, and release button loop position
Install the restriction of meter.
Accompanying drawing explanation
According to following accompanying drawing and explanation, inventive feature, advantage will become more to understand, wherein:
Fig. 1 is the schematic perspective of the Toric artificial intraocular lenses observed from prior art Toric artificial intraocular lenses's front surface
Figure, wherein button loop launches and is not folded on the surface in Toric intraocular lens optic portion；
Fig. 2 schematically shows Toric artificial intraocular lenses toric acquisition principle；
Fig. 3 schematically shows prior art Toric artificial intraocular lenses radius of curvature under different angles and optic
The situation of change of outer edge thickness；
It is 1.48 that Fig. 4 schematically shows refractive index, diopter 20D, post mirror degree 1.5D, primary mirror direction thickness 0.3mm
Outside prior art Toric intraocular lens optic portion, edge thickness is with the change curve of circumferential position angle；
Fig. 5 schematically shows after being implanted in human eye, Toric artificial intraocular lenses stress in human eye pouch
Situation；
Fig. 6 is according to an embodiment of the invention that the Toric artificial intraocular lenses's front surface from the present invention is observed
The perspective schematic view of part formula Toric artificial intraocular lenses；
Fig. 7 is the generalized section intercepting the Toric intraocular lens optic portion obtained along the line A-A' shown in Fig. 6, in order to
For the sake of Qing Chu, the button loop being connected with Toric intraocular lens optic portion outer rim not shown in this figure；
Fig. 8 schematically shows Toric artificial intraocular lenses according to an embodiment of the invention in its effective light school district
Adaptive matching (circular arc flange) at outer rim and between flange curve；
Fig. 9 schematically shows Toric artificial intraocular lenses according to an embodiment of the invention in its effective light school district
Adaptive matching (same curvature radius arc flange) at outer rim and between flange curve, shows A-A' section in this figure
The Adaptive matching of the effective light school district bus in (solid line) and B-B' section (dotted line) and its corresponding flange curve connects
Situation；
Figure 10 schematically shows Toric artificial intraocular lenses according to another embodiment of the invention at its effective optics
Adaptive matching (different curvature radius circular arc flange) at district's outer rim and between flange curve, shows A-A' section in this figure
The Adaptive matching of the effective light school district bus in (solid line) and B-B' section (dotted line) and its corresponding flange curve connects
Situation；
Figure 11 schematically show according to still another embodiment of the invention along shown in Fig. 6 line A-A' intercept obtain
Toric artificial intraocular lenses transition flange at its effective light school district outer rim and between flange curve (curve comprising straight line turns over
Limit is designed)；With
Figure 12 schematically show according to still a further embodiment along shown in Fig. 6 line A-A' intercept obtain
Toric artificial intraocular lenses transition flange at its effective light school district outer rim and between flange curve (curve of arbitrary shape turns over
Limit is designed).
Make in the drawing of the present application to be indicated with like reference numerals same or analogous element.
Drawing reference numeral explanation
1 Toric artificial intraocular lenses
2 optic
3 effective light school districts
4 optic edge parts
5 buttons loop
6 anterior optic surface
7 optic rear surfaces
The longitudinal median plane in 8-8 ' intraocular lens optic portion
9 pouches
F-pouch acts on the compression stress on artificial intraocular lenses
Fi-pouch is to artificial intraocular lenses's compression stress component on the thickest direction
Ft-pouch is to artificial intraocular lenses's compression stress component on the thinnest direction
fi-artificial intraocular lenses reaction tension force on the thickest direction
ft-artificial intraocular lenses reaction tension force on the thinnest direction
Making a concerted effort of f-artificial intraocular lenses's counteracting force
10 effective light school district outer rims
11 optic outer rims
12 effective light school district buses
13 flange curves
O optic (front or rear) surface vertices
The radius of curvature of R flange curve
A-A ' is along the hatching in Toric artificial intraocular lenses's primary mirror direction
Hatching on B-B ' arbitrarily angled (such as angle o relative to primary mirror direction) direction.
Detailed description of the invention
Specific examples below is only intended to the present invention is further explained further explanation, but the present invention is also
It is not limited to following specific embodiments.Any change on the basis of these embodiments, as long as meeting the former of the present invention
Then spirit and scope, fall within the covering scope of patent of the present invention.
The toric artificial intraocular lenses of the present invention is by refractive index hydrophobic acrylic acid's ester material system between 1.45 to 1.56
Become.Certainly, those skilled in the art may also be appreciated that, the toric artificial intraocular lenses of the present invention can also be by silica gel, water-setting
Other conventional materials such as glue or polymethyl methacrylate are made.
The front surface in toric intraocular lens optic portion in the embodiment of the present invention and the face shape of rear surface can include sphere,
One or more in the face shape of the multi-focal-plane of aspheric surface, toroid, the multi-focal-plane of multi-region refractive design and multi-region diffractive designs,
And at least one surface in the front surface in the toric intraocular lens optic portion in the embodiment of the present invention and rear surface comprises multiple song
Face is designed.
The toric artificial intraocular lenses of the present invention can be single type artificial intraocular lenses, it is also possible to be three-member type artificial intraocular lenses.According to
One embodiment of the present of invention, the optic circular in shape of the toric artificial intraocular lenses of the present invention.The toric of the present invention is artificial
The optic edge part of crystal designs part for flange, outside the purpose of this design is to make Toric crystal by effective light school district
The outside self adaptation of different-thickness of edge all angles position thickens to sustained height.
It addition, the center thickness of the optic of the toric artificial intraocular lenses of the present invention is the scope of 0.3 millimeter-1.2 millimeters
In and the thickness of optic outer rim in the range of 0.25 millimeter-0.45 millimeter." center thickness of optic " refers to this
Table before and after the optic corresponding to the center of circle (optical center) position of longitudinal center of the toric intraocular lens optic portion section of invention
Thickness between face.For those skilled in the art it is known that: in the optic of the toric artificial intraocular lenses of the present invention
Depending mainly on the size of of the thickness of the optic outer rim of the size of heart thickness and the toric artificial intraocular lenses of the present invention is selected
Material and the diopter reached.
Toric artificial intraocular lenses in the embodiment of the present invention all can reach to use most 15.0D-clinically at present
26.0D diopter.
(I) astigmatism correction type artificial intraocular lenses
Fig. 6 is the perspective schematic view of single type Toric artificial intraocular lenses according to an embodiment of the invention.Fig. 7 is
The generalized section in the Toric intraocular lens optic portion obtained, for the sake of clarity, this figure is intercepted along the line A-A' shown in Fig. 6
Not shown in the button loop that is connected with Toric intraocular lens optic portion outer rim 11.As seen from Figure 6, A-A ' direction is along Toric people
The hatching in work crystal primary mirror direction.
The optic 2 of the astigmatism correction type artificial intraocular lenses shown in Fig. 6 and Fig. 7 is by effective light school district 3 and optic edge portion
Divide 4 compositions.The diameter of described effective light school district 3 is more than or equal to 4.25 millimeters, it is preferable that the diameter of described effective light school district is more than
Equal to 5.00 millimeters.Effective light school district 3 in the front surface 6 of the optic 2 of described astigmatism correction type artificial intraocular lenses uses multiple song
Face is designed.The thickness of the optic outer rim 11 of described astigmatism correction type artificial intraocular lenses is equal and the thickness of described optic outer rim 11
H is 0.25mm-0.45mm.Preferably, the thickness h of described optic outer rim 11 is 0.25mm-0.38mm.
Those skilled in the art is it may be appreciated that anterior optic surface 6 He of described astigmatism correction type artificial intraocular lenses
The face shape of rear surface 7 can include sphere, aspheric surface, toroid, the multi-focal-plane of multi-region refractive design and multi-region diffractive designs
In one or more in the face shape of multi-focal-plane, and the anterior optic surface 6 of described astigmatism correction type artificial intraocular lenses and rear surface 7
At least one surface comprise toroid design.
As it is shown in fig. 7, effective light school district bus 12 of described astigmatism correction type artificial intraocular lenses and its corresponding flange are bent
Line 13 is connected.As it is shown in fig. 7, the thickness of effective light school district outer rim 10 is d.Preferably, described astigmatism correction type artificial intraocular lenses
Effectively light school district bus 12 and its corresponding flange curve 13 is in smoothing junction, i.e. at junction point 10, and effective light school district bus
The tangent line of the tangent line of 12 and its corresponding flange curve 13 coincides.
As it is shown in fig. 7, in this embodiment, described flange curve 13 is the circular arc with single radius of curvature R.
Fig. 8 schematically shows Toric artificial intraocular lenses according to an embodiment of the invention from its effective light school district
Outer rim starts to use single radius of curvature circular arc flange in optic edge part；Fig. 9 schematically shows according to this
The Toric artificial intraocular lenses of bright embodiment Adaptive matching at its effective light school district outer rim and between flange curve
(same curvature radius arc flange), shows the effective optics in A-A' section (solid line) and B-B' section (dotted line) in this figure
District's bus and the Adaptive matching connection of its corresponding flange curve；Figure 10 schematically shows according to the present invention's
The Toric artificial intraocular lenses of another embodiment Adaptive matching at its effective light school district outer rim and between flange curve is (no
With radius of curvature circular arc flange), this figure shows the effective light school district in A-A' section (solid line) and B-B' section (dotted line)
Bus and the Adaptive matching connection of its corresponding flange curve；Figure 11 schematically shows
The mistake at its effective light school district outer rim and between flange curve of the Toric artificial intraocular lenses according to still another embodiment of the invention
Cross flange (the curve flange comprising straight line)；Figure 12 schematically shows another according to the present invention
The Toric artificial intraocular lenses of embodiment transition flange at its effective light school district outer rim and between flange curve be (arbitrary shape
Curve flange).
From Fig. 9-12, described flange curve 13 can also be to have the circular arc of different curvature radius or other are any
The curve (including straight line) of shape.As it is shown in figure 9, (identical circular diameter (D)) is with different bent at effective light school district outer rim 10
The circular arc outward flanging of rate radius (R0.5, R1), until it reaches same optic outer rim 11 thickness h.Another kind of optional mode
It is that as shown in Figure 10, at different circular diameters, (D1, D2) is with the circular arc outward flanging of same curvature radius (R0.5), until
Reach same optic outer rim 11 thickness h.
(II) the Adaptive matching flange method for designing in astigmatism correction type intraocular lens optic portion 2 and production method
Preferably, the invention still further relates to a kind of design the astigmatism correction that optic outer rim 11 thickness described above is equal
The method of type artificial intraocular lenses 1, said method comprising the steps of:
Set diameter and the thickness h of described optic outer rim 11；
Set the link position of described effective light school district bus 12 and its corresponding flange curve 13；And
Set the radius of curvature of described flange curve 13, so that described effective light school district bus 12 is in described connection position
The tangent line of the tangent line at the place of putting flange curve 13 corresponding thereto coincides.
This method for designing can be achieved by means of computer equipment.
Preferably, described link position is positioned at effective light school district outer rim 10 and described flange curve 13 has different songs
Rate radius, as shown in Figure 10.Another kind of optional mode is, according to the feature of described effective light school district bus 12, described connection position
Setting on the circumference of different-diameter in optic and described flange curve 13 has identical radius of curvature, as shown in Figure 9.
The invention still further relates to a kind of previous designs method that uses, the astigmatism correction type that production optic outer rim 11 thickness is equal
The method of artificial intraocular lenses 1.This production method can be achieved by means of numerical control machine process equipment.
The present invention has the advantages that especially
The present invention proposes the Toric artificial intraocular lenses of a kind of optic outer rim uniform thickness, in Toric artificial intraocular lenses effective light school district
Use the design of Adaptive matching flange at outer rim, make Toric crystal by the difference of outer rim all angles position, effective light school district
The outside self adaptation of thickness thickens to sustained height, thus ensures toric intraocular lens optic portion outer rim uniform thickness, improves toric people
Work crystal positional stability in pouch, and then improve the long-term astigmatism correction effect of toric artificial intraocular lenses, and release button loop position
Install the restriction of meter.
Embodiment
Embodiment is below used in further detail the Adaptive matching flange employed in the present invention to be designed (identical song
Rate radius arc flange) be described, but those skilled in the art can appreciate that: the present invention be not limited to following these
Embodiment.
Embodiment 1
Outer edge thickness: the 0.25-0.45mm of optic
(1) diopter 15-26D, refractive index 1.45-1.56, astigmatism post mirror degree≤4.5D, flange original position diameter >=
4.25mm, flange curve curvature radius R:0-3.5mm.
(2) diopter 15-26D, refractive index 1.45-1.56, astigmatism post mirror degree≤4.5D, flange original position diameter >=
5.0mm, flange curve curvature radius R:0-1.5mm.
Embodiment 2
Outer edge thickness: the 0.25-0.38mm of optic
(1) diopter 15-26D, refractive index 1.45-1.56, astigmatism post mirror degree≤4.5D, flange original position diameter >=
4.25mm, flange curve curvature radius R:0-2.4mm.
(2) diopter 15-26D, refractive index 1.45-1.56, astigmatism post mirror degree≤4.5D, flange original position diameter >=
5.0mm, flange curve curvature radius R:0-1.0mm.
Table 1: outer edge thickness: the 0.25-0.45mm of optic, diopter 15-26D, refractive index 1.45-1.56, astigmatism post mirror
Degree≤4.5D, flange circular arc maximum curvature radius R that can use when optical area diameter reaches 4.25mm or more than 5.0mm
Embodiment described above is exemplary only and nonrestrictive.Therefore, without departing from disclosed herein
Inventive concept in the case of, above-described embodiment can be modified or change by those skilled in the art.Therefore, the present invention
Protection domain only limited by the scope of the appended claims.
Claims (15)
1. an astigmatism correction type artificial intraocular lenses, described astigmatism correction type artificial intraocular lenses includes:
The optic being made up of effective light school district and optic edge part；
The button loop being connected with described optic at optic outer rim,
The diameter of wherein said effective light school district is more than or equal to 4.25 millimeters and described effective light school district uses toroid design；
It is characterized in that,
Equal and described optic outer rim the thickness of the thickness of the optic outer rim of described astigmatism correction type artificial intraocular lenses is
0.25mm-0.45mm, wherein said optic edge part is designed as flange curve, and the radius of curvature of described flange curve sets
Become to make the bus of described effective light school district at itself and tangent line at the link position of described flange curve and corresponding flange
Curve near tangent coincides.
Astigmatism correction type artificial intraocular lenses the most according to claim 1, it is characterised in that described optic circular in shape.
Astigmatism correction type artificial intraocular lenses the most according to claim 1 and 2, it is characterised in that the thickness of described optic outer rim
Degree is 0.25mm-0.38mm.
4. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned claim 1-2, it is characterised in that described effectively
The diameter of light school district is more than or equal to 5.00 millimeters.
5. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned claim 1-2, it is characterised in that described astigmatism
The anterior optic surface of rectification type artificial intraocular lenses and the face shape of rear surface include one or more in sphere, aspheric surface, and institute
State at least one surface in the anterior optic surface of astigmatism correction type artificial intraocular lenses and rear surface and comprise toroid design.
6. according to the astigmatism correction type artificial intraocular lenses described in aforementioned claim 5, it is characterised in that described aspheric surface includes multiple song
Face, the multi-focal-plane of multi-region refractive design and the multi-focal-plane of multi-region diffractive designs.
7. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned claim 1-2, it is characterised in that described flange
Curve is the circular arc with same curvature radius.
Astigmatism correction type artificial intraocular lenses the most according to claim 7, it is characterised in that the radius of curvature of described flange curve
Scope is 0mm-2.4mm.
9. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned claim 1-2, it is characterised in that described flange
Curve is the circular arc with different curvature radius.
10. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned claim 1-2, it is characterised in that described scattered
Light rectification type artificial intraocular lenses is single type artificial intraocular lenses or three-member type artificial intraocular lenses.
11. according to the astigmatism correction type artificial intraocular lenses according to any one of aforementioned claim 1-2, it is characterised in that described scattered
Light rectification type artificial intraocular lenses is by refractive index silica gel, hydrogel, hydrophobic acrylic acid's ester or poly-methyl between 1.45 to 1.56
Acrylic acid methyl ester. is made.
The method for designing of 12. 1 kinds of astigmatism correction type artificial intraocular lensess, for design according to according to any one of claim 1-11
The equal astigmatism correction type artificial intraocular lenses of the outer edge thickness of optic, it is characterised in that described method for designing comprises the following steps:
Set diameter and the thickness of described optic outer rim；
Set the bus of described effective light school district and the link position of its corresponding flange curve；And
Set the radius of curvature of described flange curve so that the bus of described effective light school district tangent line at described link position
Flange curve near tangent corresponding thereto coincides.
13. methods according to claim 12, it is characterised in that described link position be positioned at the outer rim of effective light school district and
Described flange curve has different radius of curvature.
14. methods according to claim 12, it is characterised in that described link position is positioned at different-diameter in optic
On circumference and described flange curve has identical radius of curvature.
The production method of 15. 1 kinds of astigmatism correction type artificial intraocular lensess, it is characterised in that use according to aforementioned claim 12-14
According to any one of method for designing, produce the astigmatism correction type artificial intraocular lenses that the outer edge thickness of optic is equal.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310610150.XA CN104127262B (en) | 2013-11-27 | 2013-11-27 | Astigmatism correction type artificial intraocular lenses and design thereof and production method |
| PCT/CN2014/090351 WO2015078271A1 (en) | 2013-11-27 | 2014-11-05 | Astigmatism-correcting intraocular lens and design and production methods therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310610150.XA CN104127262B (en) | 2013-11-27 | 2013-11-27 | Astigmatism correction type artificial intraocular lenses and design thereof and production method |
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| CN104127262A CN104127262A (en) | 2014-11-05 |
| CN104127262B true CN104127262B (en) | 2016-07-27 |
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| CN201310610150.XA Active CN104127262B (en) | 2013-11-27 | 2013-11-27 | Astigmatism correction type artificial intraocular lenses and design thereof and production method |
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| WO (1) | WO2015078271A1 (en) |
Families Citing this family (11)
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| US7628810B2 (en) | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
| US9492272B2 (en) | 2009-08-13 | 2016-11-15 | Acufocus, Inc. | Masked intraocular implants and lenses |
| US10004593B2 (en) | 2009-08-13 | 2018-06-26 | Acufocus, Inc. | Intraocular lens with elastic mask |
| US9545303B2 (en) | 2011-12-02 | 2017-01-17 | Acufocus, Inc. | Ocular mask having selective spectral transmission |
| WO2017062316A1 (en) | 2015-10-05 | 2017-04-13 | Acufocus, Inc. | Methods of molding intraocular lenses |
| EP3384342B1 (en) | 2015-11-24 | 2021-08-25 | AcuFocus, Inc. | Toric small aperture intraocular lens with extended depth of focus |
| PL3557314T3 (en) | 2016-12-07 | 2024-03-25 | Kowa Company, Ltd. | Toric ocular lens |
| US11364110B2 (en) | 2018-05-09 | 2022-06-21 | Acufocus, Inc. | Intraocular implant with removable optic |
| WO2020063826A1 (en) * | 2018-09-29 | 2020-04-02 | 东莞东阳光科研发有限公司 | Intraocular lens semi-finished product forming mold, forming method and intraocular lens semi-finished product |
| CN111035471B (en) * | 2018-10-12 | 2023-12-26 | 富螺(上海)医疗器械有限公司 | Artificial crystal |
| CN110613532B (en) * | 2019-10-24 | 2022-02-22 | 西安眼得乐医疗科技有限公司 | Posterior chamber type lens designed by toric surface |
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| CN104127262A (en) | 2014-11-05 |
| WO2015078271A1 (en) | 2015-06-04 |
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