CN104127262A - Astigmatism-correcting intraocular lens and design and production methods thereof - Google Patents
Astigmatism-correcting intraocular lens and design and production methods thereof Download PDFInfo
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- CN104127262A CN104127262A CN201310610150.XA CN201310610150A CN104127262A CN 104127262 A CN104127262 A CN 104127262A CN 201310610150 A CN201310610150 A CN 201310610150A CN 104127262 A CN104127262 A CN 104127262A
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- 201000009310 astigmatism Diseases 0.000 title claims abstract description 77
- 238000004519 manufacturing process Methods 0.000 title abstract description 9
- 238000009499 grossing Methods 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 abstract description 17
- 230000007774 longterm Effects 0.000 abstract description 4
- 230000003044 adaptive effect Effects 0.000 description 14
- 238000000034 method Methods 0.000 description 13
- 210000001508 eye Anatomy 0.000 description 8
- 230000006835 compression Effects 0.000 description 7
- 238000007906 compression Methods 0.000 description 7
- 239000013078 crystal Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 230000007704 transition Effects 0.000 description 5
- 230000006978 adaptation Effects 0.000 description 3
- 230000012447 hatching Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 201000009308 regular astigmatism Diseases 0.000 description 3
- 230000002459 sustained effect Effects 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 208000029091 Refraction disease Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000004430 ametropia Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000002153 concerted effect Effects 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 201000000766 irregular astigmatism Diseases 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 208000014733 refractive error Diseases 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 101100377706 Escherichia phage T5 A2.2 gene Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention relates to an astigmatism-correcting intraocular lens and design and production methods thereof. The outer edge of an optical portion of a Toric intraocular lens is equally thick; the outer edge of an effective optical region of the Toric intraocular lens is adaptively and fitly turned; accordingly, the different thicknesses of various angled parts of the outer edge of the effective optical area are outwardly and adaptively increased to a same height, the equal thickness of the outer edge of the optical portion of the Toric intraocular lens is guaranteed, the position of the Toric intraocular lens in a sac is more stable, long-term astigmatism correction of the Toric intraocular lens is improved, and the limitations of the loop position design are eliminated.
Description
Technical field
The present invention relates generally to astigmatism correction type artificial intraocular lenses.Particularly, the present invention relates to the Toric artificial intraocular lenses for astigmatism and design and the production method that the outer edge thickness of a kind of optic equates.
Background technology
Artificial intraocular lenses (IOL) is a kind of artificial lens that can implant ophthalmic.As shown in Figure 1, artificial intraocular lenses 1 form, normally the You Yige circular light department of the Chinese Academy of Sciences 2 forms with the support button loop 5 that is arranged on optic 2 peripheries.Artificial intraocular lenses 1 optic 2 consists of efficient light school district 3 and optic marginal portion 4.
Ametropia is on the obvious a kind of factor of image quality impact, wherein astigmatism is a kind of common people's ametropia phenomenon, refer to that eyeball refractive power on different warps is inconsistent, or the diopter of same warp is not etc., so that the parallel rays that enters ophthalmic can not form focus on retina, and form the phenomenon of focal line.Astigmatism is divided into two kinds of regular astigmatism and irregular astigmatisms clinically.Two warps of refractive power difference maximum are main radial line, and two main warp lines are mutually vertical, are regular astigmatism; Each meridianal astigmatic flexibility is inconsistent, is irregular astigmatism.Wherein regular astigmatism can be corrected by eyeglass.
In normal population, corneal astigmatism is greater than the 15%-29% that accounts for of 1.5D, and has a strong impact on people's visual quality.The astigmatic up-to-date Therapeutic Method of cataract of companion is the object of correcting corneal astigmatism when an astigmatic type artificial intraocular lenses (Toric IOL) reaches normal dioptric by implanting within the eye at present.
Toric artificial intraocular lenses's development was to be proposed by Japanese Kimiya Shimizu at first, and U.S. FDA was formally examined by being applied to clinical in 1998, after this Toric artificial intraocular lenses of oneself that all released one after another of each large artificial crystal production manufacturer.These Toric artificial intraocular lensess have single type, also have three-member type; Have soft, rigid; It is hydrophilic, hydrophobic that material has; Combine aspheric surface, multifocal, also can adopt modified model " L " button loop or " C " button loop simultaneously, improve the stability of Toric artificial intraocular lenses in human eye.No matter which kind of design, the technological core of realizing the Toric artificial intraocular lenses of astigmatism correction is that the toroid in optical surface shape (toroidal) is applied to artificial intraocular lenses, extra-column mirror degree on the original dioptric basis of artificial intraocular lenses, utilize toroid inconsistent feature of diopter on each warp direction, correct the astigmatism of cataract patient cornea.
The definition of Toric face shape (toroid) is known for those skilled in the art, that is: the curve l(bus in Y-Z plane) around Y-axis, perpendicular to the straight line l ' (rotating shaft) of Z axis, rotate a circle and form (referring to Zemax Optical Design Program Users Guide page 272, Toroidal part).Curve l can be round, can be also aspheric curve, and l ' is rotating shaft radius to the distance in the bus center of circle, as shown in Figure 2 (graphic extension of toric acquisition principle).
No matter bus is spherical curve is still aspheric curve, by the derivation of equation, (respective formula can be at optical tooling book, as Daniel Malacara, Handbook of optical design, chapter 2, formula A2.2 and formula A2.5(are shown in appendix)) and Theoretical Calculation can know: for toric artificial intraocular lenses, determined primary mirror and the radius of curvature of post mirror direction and artificial intraocular lenses's center thickness (or edge thickness of primary mirror direction), the thickness at the each point place of intraocular lens optic portion outer rim is all determined.
Fig. 3 shows the radius of curvature of Toric artificial intraocular lenses under different angles and the situation of change of thickness.For toric artificial intraocular lenses, on Radius in office (as Fig. 3 radius r), eyeglass is different in each radius of curvature in the radial direction, and thickness is different, as shown in Figure 3, and the maximum (R of primary mirror directional curvature radius
0), the thickest (d of while
0), the minimum (R of post mirror directional curvature radius
90), the thinnest (d of while
90), the radius of curvature of all the other directions and thickness is between the two, gradually transition change.Correspondingly, the thickness of Toric intraocular lens optic portion outer rim also meets this rule, and became uneven, the thickest with primary mirror direction, and post mirror direction is the thinnest, and in all the other directions, thickness is between the two.Again for example, it is 1.48 that Fig. 4 shows refractive index, diopter 20D, and post mirror degree 1.5D, the thickness d of the toric intraocular lens optic portion outer rim of the thick 0.3mm of primary mirror direction (unit is millimeter) is with the change curve of circumferential position angle A (unit is degree).By simple Theoretical Calculation, derive and just can find and as shown in Figure 4: the thickness distribution of toric intraocular lens optic portion outer rim meets sin/cos curve distribution rule along circumferential thickness.
Yet the phenomenon along circumferential became uneven of this optic outer rim brings following problem can to toric artificial intraocular lenses:
(1) make Toric artificial intraocular lenses all directions unbalance stress in human eye pouch, cause Toric artificial intraocular lenses to rotate off normal, affect astigmatism correction effect.
Artificial intraocular lenses puts into after human eye pouch 9, and pouch supports button loop 5 to artificial intraocular lenses and exerts pressure, and artificial intraocular lenses is corresponding can produce counteracting force, maintains the position stability of artificial intraocular lenses in pouch.The force analysis of Toric artificial intraocular lenses in pouch is shown in Fig. 5.Pouch 9 supports button loop by compression, and intraocular lens optic portion 2 is applied to compression stress F, and this power can be decomposed into the component in all directions, such as the power F being decomposed in the thinnest direction of Toric artificial intraocular lenses
tpower F in the thickest direction
i, (F as shown in Figure 5
1t, F
2t; And F
1i, F
2i); Toric artificial crystal material produces retroaction tension force f to the compression stress of pouch
iwith f
t, (f as shown in Figure 5
1t, f
2t; And f
1i, f
2i), due to Toric artificial intraocular lenses marginal portion became uneven, cause the support force f of thin direction
tdiminish, pouch applied pressure can not be offset completely in two thin directions, the f that makes a concerted effort that Toric artificial intraocular lenses produces in all directions is all not identical in size and direction with the compression stress F of pouch, these two revolving forces that there is no the power formation Toric artificial intraocular lenses circumferencial direction of counteracting, cause Toric artificial intraocular lenses rotation.
Astigmatism correction type artificial intraocular lenses has strict requirement to crystal astigmatism axle and corneal astigmatism shaft alignement, clinical practice shows, implant Toric artificial intraocular lenses, 1 ° of the every rotation of Toric artificial intraocular lenses, can cause 3.3% lens cylinder mirror degree loss, Toric artificial intraocular lenses rotates 30 ° of > or more, can cause the complete failure of astigmatism correction, so the rotation of Toric artificial intraocular lenses's this circumferencial direction can produce and have a strong impact on to astigmatism correction.And the Toric artificial intraocular lenses that the pouch active force inequality that this optic outer rim became uneven causes causes rotation is accumulated over a long period, can not stop along with the increase of Toric artificial intraocular lenses Implantation Time accumulation and increase the weight of.
(2) be subject to the fastening with a rope, string, etc. restriction of support force, artificial intraocular lenses's button loop need to guarantee certain thickness.Yet, Toric artificial intraocular lenses forms restriction to the Position Design of button loop, the phenomenon of brim-portion thickness inequality must design button loop in the thickest direction of Toric intraocular lens optic portion's outer rim Toric artificial intraocular lenses, to guarantee enough thickness and enough support forces, limited thus doctor and patient's selection.
Summary of the invention
The present invention proposes in view of the above problems, its object is to provide a kind of optic the outer equal Toric artificial intraocular lenses of edge thickness, to improving the positional stability of Toric artificial intraocular lenses in pouch, and then improve toric artificial intraocular lenses's long-term astigmatism correction effect, and remove the restriction of button loop Position Design.
Term definition
The term " optic " using in this application refers to the rounded optical lens (as shown in the Reference numeral 2 in Fig. 1, Fig. 6) of the section 8-8 ' of longitudinal center consisting of artificial intraocular lenses's efficient light school district and optic marginal portion around thereof.
The term " efficient light school district " using in this application thus refer to the part that optical characteristics can realize the major function that regulates artificial intraocular lenses's diopter and/or astigmatism that has that is positioned at intraocular lens optic portion center.Particularly, the diameter of the toric artificial intraocular lenses's who uses in the embodiment of the present invention optic is approximately 6 millimeters (maximum can reach 6.5 millimeters), wherein efficient light school district refer to the optic marginal portion that is positioned at toric artificial intraocular lenses with circular portion, its diameter is more than or equal to 4.25 millimeters.
The term " optic marginal portion " using in this application refers to the annular marginal area of the optical characteristics that can not affect artificial intraocular lenses that is arranged on periphery, intraocular lens optic portion efficient light school district.
The term " efficient light school district outer rim " using in this application refers to for the rounded artificial intraocular lenses of the section 8-8 ' of longitudinal center of optic, the vertical section of circular efficient light school district perimeter edge of take waits radius circumferential position to the distance between the vertical section O'-O'' through the optical center O of optic in the intraocular lens optic portion that radius limits, referring to Figure of description Fig. 6.
The term " optic outer rim " using in this application refers to for the rounded artificial intraocular lenses of longitudinal center's section of optic, and the vertical section of circular light department of the Chinese Academy of Sciences perimeter edge of take waits radius circumferential position to the distance between the vertical section O'-O'' of the optical center O through optic in the intraocular lens optic portion that radius limits.
The term " anterior optic surface " using in this application refers to tailing edge axis oculi direction that optic surface nearer apart from eye cornea in artificial intraocular lenses is implanted to human eye.
The term " optic rear surface " using in this application refers to that optic surface relative with above-mentioned anterior optic surface in artificial intraocular lenses.
The term " button loop " using in this application refers to intraocular lens optic portion and is connected, has not only played the effect of support of optical portion but also plays the part that the contractility that the contraction of ciliary muscle and varicose are produced is delivered to the effect of described optic.
Use in this application the term for example " protruding " that represents shape, " recessed " is for the longitudinal median plane 8-8 ' of intraocular lens optic portion.
For the Toric artificial intraocular lenses in the application, the term using in the application " anterior optic surface summit " refers to the central point in described artificial intraocular lenses's anterior optic surface.Also can say, anterior optic surface summit refers to: the point (referring to the Reference numeral O' in Fig. 7) farthest of the distance in described artificial intraocular lenses's anterior optic surface and between the longitudinal median plane of this intraocular lens optic part; The term using in the application " summit, optic rear surface " refers to the central point on described artificial intraocular lenses's optic rear surface.Also can say, summit, optic rear surface refers to: the point (referring to the Reference numeral O'' in Fig. 7) farthest of the distance on described artificial intraocular lenses's optic rear surface and between the longitudinal median plane of this intraocular lens optic part.
The term using in the application " efficient light school district bus " refers to according to above described toric definition campaign and produces the curve on surface, efficient light school district.
The term using in the application " flange curve " refers to the curve that certainly effective Optical Region outer rim corresponding with specific efficient light school district bus in optic marginal portion extends to optic outer rim.
The term using in the application " design of Adaptive matching flange " refers to the design that the bus flange curve smoothing corresponding with it in efficient light school district is connected, the design coinciding at the tangent line of efficient light school district, junction point place bus and its corresponding flange curve.
Particularly, the present invention relates to the content of following many aspects:
1. an astigmatism correction type artificial intraocular lenses, described astigmatism correction type artificial intraocular lenses comprises:
The optic being formed by efficient light school district and optic marginal portion;
The button loop being connected with described optic at optic outer rim place,
The diameter of wherein said efficient light school district is more than or equal to 4.25 millimeters and the design of described efficient light school district employing toroid;
It is characterized in that,
The thickness of described astigmatism correction type artificial intraocular lenses's optic outer rim equates and the thickness of described optic outer rim is 0.25mm-0.45mm.
2. according to the astigmatism correction type artificial intraocular lenses described in aspect 1, it is characterized in that the rounded shape of described optic.
3. according to the astigmatism correction type artificial intraocular lenses described in aspect 1 or 2, it is characterized in that, the thickness of described optic outer rim is 0.25mm-0.38mm.
4. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned aspect 1-3, it is characterized in that, the diameter of described efficient light school district is more than or equal to 5.00 millimeters.
5. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned aspect 1-4, it is characterized in that, described astigmatism correction type artificial intraocular lenses's anterior optic surface and the face shape of rear surface comprise one or more in the face shape of multifocal of sphere, aspheric surface, toroid, multi-region refractive design multifocal and multi-region diffractive designs, and described astigmatism correction type artificial intraocular lenses's anterior optic surface and at least one surface in rear surface comprise toroid design.
6. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned aspect 1-5, it is characterized in that, part is designed for flange in described optic marginal portion.
7. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned aspect 1-6, it is characterized in that, the flange curve that described astigmatism correction type artificial intraocular lenses's the efficient light school district bus described flange corresponding with it designs in part is connected.
8. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned aspect 1-7, it is characterized in that, the flange curve smoothing that described astigmatism correction type artificial intraocular lenses's the efficient light school district bus described flange corresponding with it designs in part is connected.
9. according to aforementioned aspect 1-6, the astigmatism correction type artificial intraocular lenses in 8 described in any one, is characterized in that, described flange curve is the circular arc with same curvature radius.
10. according to the astigmatism correction type artificial intraocular lenses described in aspect 9, it is characterized in that, the range of curvature radius of described flange curve is 0mm-2.4mm.
11. according to aforementioned aspect 1-6, and the astigmatism correction type artificial intraocular lenses in 8 described in any one is characterized in that, described flange curve is the circular arc with different curvature radius.
12. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned aspect 1-11, it is characterized in that, described astigmatism correction type artificial intraocular lenses is single type artificial intraocular lenses or three-member type artificial intraocular lenses.
13. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned aspect 1-12, it is characterized in that, described astigmatism correction type artificial intraocular lenses by refractive index the silica gel 1.45 to 1.56, hydrogel, hydrophobic acrylic acid's ester or polymethyl methacrylate make.
The astigmatism correction type artificial intraocular lenses's that outside optic in 14. 1 kinds of design consideration aspect 8-13 described in any one, edge thickness is equal method, said method comprising the steps of:
Set diameter and the thickness of described optic outer rim;
Set the link position of described efficient light school district bus and its corresponding flange curve; And
Set the radius of curvature of described flange curve, thereby described efficient light school district bus is coincided at the tangent line of the tangent line at described link position place flange curve corresponding thereto.
15. according to the method described in aspect 14, it is characterized in that, described link position is positioned at outer rim place, efficient light school district and described flange curve has different radius of curvature.
16. according to the method described in aspect 14, it is characterized in that, described link position is arranged on the circumference of optic different-diameter and described flange curve has identical radius of curvature.
17. 1 kinds of employings are according to the method for designing described in any one in aforementioned aspect 14-16, the astigmatism correction type artificial intraocular lenses's that the outer edge thickness of production optic is equal method.
The present invention has following beneficial effect especially:
The present invention proposes a kind of Toric artificial intraocular lenses of optic outer rim uniform thickness, at outer rim place, Toric artificial intraocular lenses efficient light school district, adopt the design of Adaptive matching flange, Toric crystal is thickened to sustained height by the outside self adaptation of different-thickness of outer rim all angles position, efficient light school district, thereby guarantee toric intraocular lens optic portion outer rim uniform thickness, improve the positional stability of toric artificial intraocular lenses in pouch, and then improve toric artificial intraocular lenses's long-term astigmatism correction effect, and remove the restriction of button loop Position Design.
Accompanying drawing explanation
According to following accompanying drawing and explanation, feature of the present invention, advantage will become more clear, wherein:
Fig. 1 is the Toric artificial intraocular lenses's that observes from prior art Toric artificial intraocular lenses front surface perspective schematic view, and wherein button loop launches and is not folded on the surface of Toric intraocular lens optic portion;
Fig. 2 schematically shows the toric acquisition principle of Toric artificial intraocular lenses;
Fig. 3 schematically shows the situation of change of edge thickness outside the radius of curvature of prior art Toric artificial intraocular lenses under different angles and optic;
It is 1.48 that Fig. 4 schematically shows refractive index, diopter 20D, and post mirror degree 1.5D, outside the prior art Toric intraocular lens optic portion of the thick 0.3mm of primary mirror direction, edge thickness is with the change curve of circumferential position angle;
After Fig. 5 schematically shows in being implanted to human eye, the stressing conditions of Toric artificial intraocular lenses in human eye pouch;
Fig. 6 is the single type Toric artificial intraocular lenses's according to an embodiment of the invention that observes from Toric artificial intraocular lenses front surface of the present invention perspective schematic view;
Fig. 7 is the generalized section of the Toric intraocular lens optic portion that obtains along the line A-A' intercepting shown in Fig. 6, for the sake of clarity, and this not shown button loop being connected with Toric intraocular lens optic portion outer rim;
Fig. 8 schematically shows the Adaptive matching (circular arc flange) of Toric artificial intraocular lenses according to an embodiment of the invention between its outer rim place, efficient light school district and flange curve;
Fig. 9 schematically shows the Adaptive matching (same curvature radius arc flange) of Toric artificial intraocular lenses according to an embodiment of the invention between its outer rim place, efficient light school district and flange curve, and this there is shown the Adaptive matching connection of efficient light school district bus in A-A' section (solid line) and B-B' section (dotted line) and its corresponding flange curve;
Figure 10 schematically shows the Toric artificial intraocular lenses according to another embodiment of the invention Adaptive matching (different curvature radius circular arc flange) between its outer rim place, efficient light school district and flange curve, and this there is shown efficient light school district bus in A-A' section (solid line) and B-B' section (dotted line) and the Adaptive matching connection of its corresponding flange curve;
Figure 11 schematically shows the Toric artificial intraocular lenses who obtains along the line A-A' intercepting shown in Fig. 6 according to still another embodiment of the invention transition flange (the curve flange that comprises straight line designs) between its outer rim place, efficient light school district and flange curve; With
Figure 12 schematically shows the Toric artificial intraocular lenses who obtains along the line A-A' intercepting shown in Fig. 6 according to still a further embodiment transition flange (the curve flange of arbitrary shape designs) between its outer rim place, efficient light school district and flange curve.
In the application's accompanying drawing, use identical drawing reference numeral to represent same or analogous element.
Drawing reference numeral explanation
1 Toric artificial intraocular lenses
2 optic
3 efficient light school districts
4 optic marginal portions
5 buttons loop
6 anterior optic surface
7 optic rear surfaces
The longitudinal median plane of 8-8 ' intraocular lens optic portion
9 pouches
F-pouch acts on the compression stress on artificial intraocular lenses
F
i-pouch is the component in the thickest direction to artificial intraocular lenses's compression stress
F
t-pouch is the component in the thinnest direction to artificial intraocular lenses's compression stress
F
ithe retroaction tension force of-artificial intraocular lenses in the thickest direction
F
tthe retroaction tension force of-artificial intraocular lenses in the thinnest direction
Making a concerted effort of f-artificial intraocular lenses counteracting force
10 efficient light school district outer rims
11 optic outer rims
12 efficient light school district buses
13 flange curves
O optic (front or rear) surface vertices
The radius of curvature of R flange curve
A-A ' is along the hatching of Toric artificial intraocular lenses primary mirror direction
For example, hatching in B-B ' arbitrarily angled (being θ angle with respect to primary mirror direction) direction.
The specific embodiment
Following specific embodiment is just for further the present invention being explained further, but the present invention is not limited to following specific embodiments.Any variation on these embodiment bases, as long as spirit according to the invention and scope all will fall in the covering scope of patent of the present invention.
Toric artificial intraocular lenses of the present invention by refractive index the hydrophobic acrylic acid's ester material 1.45 to 1.56 make.Certainly, those skilled in the art also can recognize, toric artificial intraocular lenses of the present invention also can be made by other conventional materials such as silica gel, hydrogel or polymethyl methacrylates.
The front surface of toric intraocular lens optic portion in the embodiment of the present invention and the face shape of rear surface can comprise one or more in the face shape of multifocal of sphere, aspheric surface, toroid, multi-region refractive design multifocal and multi-region diffractive designs, and the front surface of the toric intraocular lens optic portion in the embodiment of the present invention and at least one surface in rear surface comprise toroid design.
Toric artificial intraocular lenses of the present invention can be single type artificial intraocular lenses, can be also three-member type artificial intraocular lenses.According to one embodiment of present invention, the rounded shape of toric artificial intraocular lenses's of the present invention optic.Part is designed for flange in toric artificial intraocular lenses's of the present invention optic marginal portion, and the object of this design is to make Toric crystal to be thickened to sustained height by the outside self adaptation of different-thickness of outer rim all angles position, efficient light school district.
In addition, the center thickness of toric artificial intraocular lenses's of the present invention optic in the scope of 0.3 millimeter-1.2 millimeters and the thickness of optic outer rim in the scope of 0.25 millimeter-0.45 millimeter." center thickness of optic " refers to the thickness between the corresponding optic front and rear surfaces in position, the center of circle (optical center) of longitudinal center of toric intraocular lens optic of the present invention portion section.Known for those skilled in the art: the size of the thickness of the size of the center thickness of toric artificial intraocular lenses's of the present invention optic and toric artificial intraocular lenses's of the present invention optic outer rim depends primarily on selected material and the diopter reaching.
Toric artificial intraocular lenses in the embodiment of the present invention all can reach the diopter that uses clinically maximum 15.0D-26.0D at present.
(I) astigmatism correction type artificial intraocular lenses
Fig. 6 is single type Toric artificial intraocular lenses's according to an embodiment of the invention perspective schematic view.Fig. 7 is the generalized section of the Toric intraocular lens optic portion that obtains along the line A-A' intercepting shown in Fig. 6, for the sake of clarity, and this not shown button loop being connected with Toric intraocular lens optic portion outer rim 11.As seen from Figure 6, A-A ' direction is the hatching along Toric artificial intraocular lenses primary mirror direction.
The optic 2 of astigmatism correction type artificial intraocular lenses shown in Fig. 6 and Fig. 7 consists of efficient light school district 3 and optic marginal portion 4.The diameter of described efficient light school district 3 is more than or equal to 4.25 millimeters, and preferably, the diameter of described efficient light school district is more than or equal to 5.00 millimeters.Efficient light school district 3 in the front surface 6 of described astigmatism correction type artificial intraocular lenses's optic 2 adopts toroid design.The thickness of described astigmatism correction type artificial intraocular lenses's optic outer rim 11 equates and the thickness h of described optic outer rim 11 is 0.25mm-0.45mm.Preferably, the thickness h of described optic outer rim 11 is 0.25mm-0.38mm.
Those skilled in the art can recognize: described astigmatism correction type artificial intraocular lenses's anterior optic surface 6 and the face shape of rear surface 7 can comprise one or more in the face shape of multifocal of sphere, aspheric surface, toroid, multi-region refractive design multifocal and multi-region diffractive designs, and described astigmatism correction type artificial intraocular lenses's anterior optic surface 6 and at least one surface in rear surface 7 comprise toroid design.
As shown in Figure 7, described astigmatism correction type artificial intraocular lenses's the efficient light school district bus 12 flange curve 13 corresponding with it is connected.As shown in Figure 7, the thickness of efficient light school district outer rim 10 is d.Preferably, efficient light school district bus 12 and its corresponding flange curve 13 smooth connections of described astigmatism correction type artificial intraocular lenses, at junction point 10 places, the tangent line of the tangent line of efficient light school district bus 12 and its corresponding flange curve 13 coincides.
As shown in Figure 7, in this embodiment, described flange curve 13 is for having the circular arc of single radius of curvature R.
Fig. 8 schematically shows Toric artificial intraocular lenses according to an embodiment of the invention and starts to adopt single radius of curvature circular arc flange from its efficient light school district outer rim in optic marginal portion; Fig. 9 schematically shows the Adaptive matching (same curvature radius arc flange) of Toric artificial intraocular lenses according to an embodiment of the invention between its outer rim place, efficient light school district and flange curve, and this there is shown the Adaptive matching connection of efficient light school district bus in A-A' section (solid line) and B-B' section (dotted line) and its corresponding flange curve; Figure 10 schematically shows the Toric artificial intraocular lenses according to another embodiment of the invention Adaptive matching (different curvature radius circular arc flange) between its outer rim place, efficient light school district and flange curve, and this there is shown efficient light school district bus in A-A' section (solid line) and B-B' section (dotted line) and the Adaptive matching connection of its corresponding flange curve; Figure 11 schematically shows the Toric artificial intraocular lenses according to still another embodiment of the invention transition flange (the curve flange that comprises straight line) between its outer rim place, efficient light school district and flange curve; Figure 12 schematically shows the Toric artificial intraocular lenses according to still a further embodiment transition flange (the curve flange of arbitrary shape) between its outer rim place, efficient light school district and flange curve.
From Fig. 9-12, described flange curve 13 can be also to have the circular arc of different curvature radius or the curve of other any shapes (comprising straight line).As shown in Figure 9, the circular arc outward flanging at outer rim 10 places, efficient light school district (identical circular diameter (D)) with different curvature radius (R0.5, R1), until reach same optic outer rim 11 thickness h.Another kind of optional mode is that as shown in figure 10, the circular arc outward flanging at different circular diameter places (D1, D2) with same curvature radius (R0.5), until reach same optic outer rim 11 thickness h.
(II) Adaptive matching flange method for designing and the production method of astigmatism correction type intraocular lens optic portion 2
Preferably, the invention still further relates to the astigmatism correction type artificial intraocular lenses's 1 that optic outer rim 11 thickness described in a kind of design are above equal method, said method comprising the steps of:
Set diameter and the thickness h of described optic outer rim 11;
Set the link position of described efficient light school district bus 12 and its corresponding flange curve 13; And
Set the radius of curvature of described flange curve 13, thereby the tangent line of described efficient light school district bus 12 tangent lines at described link position place flange curve 13 is corresponding thereto coincided.
This method for designing can be achieved by means of computer equipment.
Preferably, described link position is positioned at outer rim 10 places, efficient light school district and described flange curve 13 has different radius of curvature, as shown in figure 10.Another kind of optional mode is, according to the feature of described efficient light school district bus 12, described link position is arranged on the circumference of optic different-diameter and described flange curve 13 has identical radius of curvature, as shown in Figure 9.
The invention still further relates to a kind of employing previous designs method, the astigmatism correction type artificial intraocular lenses's 1 that production optic outer rim 11 thickness are equal method.This production method can be achieved by means of numerical control machine process equipment.
The present invention has following beneficial effect especially:
The present invention proposes a kind of Toric artificial intraocular lenses of optic outer rim uniform thickness, at outer rim place, Toric artificial intraocular lenses efficient light school district, adopt the design of Adaptive matching flange, Toric crystal is thickened to sustained height by the outside self adaptation of different-thickness of outer rim all angles position, efficient light school district, thereby guarantee toric intraocular lens optic portion outer rim uniform thickness, improve the positional stability of toric artificial intraocular lenses in pouch, and then improve toric artificial intraocular lenses's long-term astigmatism correction effect, and remove the restriction of button loop Position Design.
Embodiment
Below adopt embodiment in further detail the Adaptive matching flange design (same curvature radius arc flange) adopting in the present invention to be described, but those skilled in the art can recognize: the present invention is not limited to these embodiment below.
Embodiment 1
Outer edge thickness: the 0.25-0.45mm of optic
(1) diopter 15-26D, refractive index 1.45-1.56, astigmatic post mirror degree≤4.5D, flange original position diameter >=4.25mm, flange curve curvature radius R:0-3.5mm.
(2) diopter 15-26D, refractive index 1.45-1.56, astigmatic post mirror degree≤4.5D, flange original position diameter >=5.0mm, flange curve curvature radius R:0-1.5mm.
Embodiment 2
Outer edge thickness: the 0.25-0.38mm of optic
(1) diopter 15-26D, refractive index 1.45-1.56, astigmatic post mirror degree≤4.5D, flange original position diameter >=4.25mm, flange curve curvature radius R:0-2.4mm.
(2) diopter 15-26D, refractive index 1.45-1.56, astigmatic post mirror degree≤4.5D, flange original position diameter >=5.0mm, flange curve curvature radius R:0-1.0mm.
Table 1: outer edge thickness: the 0.25-0.45mm of optic, diopter 15-26D, refractive index 1.45-1.56, astigmatic post mirror degree≤4.5D, optical area diameter reaches the flange circular arc maximum curvature radius R that 4.25mm or 5.0mm can be used when above
Embodiment is above only illustrative rather than restrictive.Therefore,, in the situation that not departing from invention disclosed herein design, those skilled in the art can modify or change above-described embodiment.Therefore, protection scope of the present invention is only limited by the scope of appended claims.
Claims (10)
1. an astigmatism correction type artificial intraocular lenses, described astigmatism correction type artificial intraocular lenses comprises:
The optic being formed by efficient light school district and optic marginal portion;
The button loop being connected with described optic at optic outer rim place,
The diameter of wherein said efficient light school district is more than or equal to 4.25 millimeters and the design of described efficient light school district employing toroid;
It is characterized in that,
The thickness of described astigmatism correction type artificial intraocular lenses's optic outer rim equates and the thickness of described optic outer rim is 0.25mm-0.45mm.
2. astigmatism correction type artificial intraocular lenses according to claim 1, is characterized in that, the rounded shape of described optic.
3. astigmatism correction type artificial intraocular lenses according to claim 1 and 2, is characterized in that, the thickness of described optic outer rim is 0.25mm-0.38mm.
4. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned claim 1-3, it is characterized in that, the diameter of described efficient light school district is more than or equal to 5.00 millimeters.
5. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned claim 1-4, it is characterized in that, described astigmatism correction type artificial intraocular lenses's anterior optic surface and the face shape of rear surface comprise one or more in the face shape of multifocal of sphere, aspheric surface, toroid, multi-region refractive design multifocal and multi-region diffractive designs, and described astigmatism correction type artificial intraocular lenses's anterior optic surface and at least one surface in rear surface comprise toroid design.
6. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned claim 1-5, it is characterized in that, part is designed for flange in described optic marginal portion.
7. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned claim 1-6, it is characterized in that, the flange curve that described astigmatism correction type artificial intraocular lenses's the efficient light school district bus described flange corresponding with it designs in part is connected.
8. according to the astigmatism correction type artificial intraocular lenses described in any one in aforementioned claim 1-7, it is characterized in that, the flange curve smoothing that described astigmatism correction type artificial intraocular lenses's the efficient light school district bus described flange corresponding with it designs in part is connected.
9. according to aforementioned claim 1-6, the astigmatism correction type artificial intraocular lenses in 8 described in any one, is characterized in that, described flange curve is the circular arc with same curvature radius.
10. astigmatism correction type artificial intraocular lenses according to claim 9, is characterized in that, the range of curvature radius of described flange curve is 0mm-2.4mm.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310610150.XA CN104127262B (en) | 2013-11-27 | 2013-11-27 | Astigmatism correction type artificial intraocular lenses and design thereof and production method |
| PCT/CN2014/090351 WO2015078271A1 (en) | 2013-11-27 | 2014-11-05 | Astigmatism-correcting intraocular lens and design and production methods therefor |
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| CN201310610150.XA CN104127262B (en) | 2013-11-27 | 2013-11-27 | Astigmatism correction type artificial intraocular lenses and design thereof and production method |
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| CN104127262A true CN104127262A (en) | 2014-11-05 |
| CN104127262B CN104127262B (en) | 2016-07-27 |
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| WO (1) | WO2015078271A1 (en) |
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| CN110613532A (en) * | 2019-10-24 | 2019-12-27 | 西安浦勒生物科技有限公司 | Posterior chamber type lens designed by toric surface |
| CN111971154A (en) * | 2018-09-29 | 2020-11-20 | 东莞东阳光医疗智能器件研发有限公司 | Artificial crystal semi-finished product forming die, forming method and artificial crystal semi-finished product |
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| WO2015078271A1 (en) | 2015-06-04 |
| CN104127262B (en) | 2016-07-27 |
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Denomination of invention: Astigmatism-correcting intraocular lens and design and production methods thereof Effective date of registration: 20170925 Granted publication date: 20160727 Pledgee: Pudong Development Silicon Valley Bank Co., Ltd. Beijing branch Pledgor: Eyebright (Beijing) Medical Technology Co., Ltd. Registration number: 2017990000900 |
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