CN103977752B - A kind of accumulation output device of laser pre-polarizing xenon - Google Patents
A kind of accumulation output device of laser pre-polarizing xenon Download PDFInfo
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Abstract
A kind of laser pre-polarizing of the present invention xenon accumulation output device, vacuum valve connects L shape glass tube, glass container, vacuum sleeve, glass tube successively; Aluminium chassis upper end is connected with container holder, permanent magnet respectively; Vacuum sleeve and glass tube successively through container holder, aluminium chassis and the perforate of permanent magnet upper end, the lifting pedestal of electric controller successively on connecting cable, aluminium chassis; Lifting platform track connects travelling carriage, translation stage track, the travelling carriage of translation stage, lifting platform positioning slide, lifting platform positioning slide seat, the aluminium chassis of lifting platform successively; The travelling carriage of translation stage connects successively temp. controllable glass bottle holder and Dewar container for liquefied nitrogen bottle holder, aluminium chassis is connecting container seat, permanent magnet, electric controller, lifting pedestal and lifting platform positioning slide seat successively.Structure is simple, easy to operate, accumulation exports integration, can be provided as the high polarizability of contrast preparation and the laser pre-polarizing gaseous xenon of high yield for magnetic resonance imaging system.
Description
Technical field
The present invention relates to nuclear magnetic resonance and mr imaging technique field, more specifically relate to a kind of accumulation output device of laser pre-polarizing xenon, be applicable to the laser pre-polarizing magnetic resonance contrast agent of thermal nonequilibrium nuclear spin polarization degree.
Background technology
Laser pre-polarizing magnetic resonance contrast agent (such as xenon-129), in animal or human lung and the visual or clinical early stage medical diagnosis on disease of brain function, has very important, potential application foreground.In the laser pre-polarizing system using " type of flow " or " batch (-type) " to work, be usually equipped with a set of device laser pre-polarizing xenon being cured Cumulate Sum and storing.So, after laser pre-polarizing system works a period of time, create the Large Copacity solid-state laser pre-polarizing xenon that can meet organism structure and functional study.At this moment, need to be distilled into gaseous state, just can be input in the organism comprising human lung or brain and carry out magnetic resonance spectrum detection or magnetic resonance imaging.
Use xenon-133 gas as the organism magnetic resonance imaging of contrast preparation, particularly human lung or brain magnetic resonance imaging, require to produce the gaseous xenon with Large Copacity, high polarizability.One of wherein important problem is: the height thermal nonequilibrium nuclear spin polarization degree how keeping laser pre-polarizing xenon, does the Cumulate Sum output procedure for it provide a suitable working environment and condition?
Existing certain methods and technology as follows:
A () is usual, only need the solid-state Cumulate Sum storage device that use one and laser pre-polarizing xenon are supporting.After the cold-trap of laser pre-polarizing xenon is equipped with in taking-up in liquid nitrogen, it is allowed naturally to distil as gaseous state.The method of this solid state sublimation is the simplest, without any need for other servicing unit.But this sublimation process relies on room temperature, needs the time relatively grown, owing to there is no externally-applied magnetic field outside cold-trap, the part thermal nonequilibrium nuclear spin polarization degree losing laser pre-polarizing xenon can be made.
B () utilizes a hand-operated lifting platform, the magnetic field units in solid-state Cumulate Sum storage device, Dewar container for liquefied nitrogen are fallen, leave the cold-trap that laser pre-polarizing solid xenon is housed.This method is analogous to method (a), is also to allow solid xenon at room temperature distil gradually, does not provide an externally-applied magnetic field to cold-trap equally, and the effect of generation is identical with (a) method.
C the method for () a kind of improvement, utilizes a hand-operated lifting platform, fallen by the Dewar container for liquefied nitrogen in solid-state Cumulate Sum storage device, leave cold-trap and magnetic field units that laser pre-polarizing xenon is housed.Like this, cold-trap have left liquid nitrogen, still remains in magnetic field units, and external magnetic field can reduce the polarizability loss of laser pre-polarizing xenon.But the same with (b) as method (a), solid xenon still at room temperature distils gradually, need the time that one relatively long, still there is the part thermal nonequilibrium nuclear spin polarization degree loss problem of laser pre-polarizing xenon.
Obviously, existing Method and Technology comes with some shortcomings part.In order to solve the problem, make laser pre-polarizing xenon system have higher operating efficiency and performance further, be necessary to develop pointedly a kind of not only maintain laser pre-polarizing xenon height thermal nonequilibrium nuclear spin polarization degree, but also include the device that Cumulate Sum exports.
Summary of the invention
For the some shortcomings that existing technology exists, the object of the invention is the accumulation output device that there are provided a kind of laser pre-polarizing xenon, structure is simple, easy to operate, accumulation exports integration, in a magnetic field environment, checker liquid nitrogen and constant-temperature hot water two kinds of temperature environments, utilize its characteristic, with the system combined use of laser pre-polarizing xenon, the high polarizability of contrast preparation and the laser pre-polarizing gaseous xenon of high yield can be provided as magnetic resonance imaging system.
In order to realize above-mentioned object, the present invention adopts following technical measures:
Its technical conceive is: when from laser pre-polarizing system, include laser pre-polarizing gaseous xenon after interior mist flows into apparatus of the present invention, design is positioned over separating mixed gas in the liquid nitrogen temperature glass container in field region at one, become except solid xenon except laser pre-polarizing gaseous xenon is freezing, other gas (such as the nitrogen of cancellation laser pump (ing) process Atom fluorescence, for allowing atomic vapour live width coincide the helium of pressure broadening of laser linewidth) because can not be frozen, be still gaseous state and flow out apparatus of the present invention.Continuously flowing into of mist, makes repetition said process, realizes the accumulation of laser pre-polarizing xenon.After mist stops flowing into apparatus of the present invention, by on Electronic control make constant-temperature hot water replace glass container that liquid nitrogen and being provided to is positioned in field region, rapid distillation solid xenon becomes the laser pre-polarizing gaseous xenon still keeping height thermal nonequilibrium nuclear spin polarization, then apparatus of the present invention are flowed out in magnetic resonance imaging system, as the contrast preparation of organism research (such as human lung or brain).
An accumulation output device for laser pre-polarizing xenon, it comprises two vacuum valves, L shape glass tube, glass tube, container holder, aluminium chassis, electric controller, cable, lifting platform track, the travelling carriage of lifting platform, glass container, vacuum sleeve, permanent magnet, lifting platform positioning slide, Dewar container for liquefied nitrogen bottle, temp. controllable vial, lifting pedestal, temp. controllable glass bottle holder, the travelling carriage of translation stage, Dewar container for liquefied nitrogen bottle holder, translation stage track, lifting platform positioning slide seat.It is characterized in that: the first vacuum valve is connected successively L shape glass tube, glass container, vacuum sleeve, glass tube, the second vacuum valve; Aluminium chassis upper end is connected with container holder, permanent magnet respectively; Then, allow the glass container including vacuum sleeve successively through the mesopore of container holder, aluminium chassis and make the bottom of glass container enter into the center of permanent magnet; Electric controller is connecting cable and the lifting pedestal be arranged on aluminium chassis successively; Lifting platform track connects travelling carriage, translation stage track, the travelling carriage of translation stage, lifting platform positioning slide, lifting platform positioning slide seat, the aluminium chassis of lifting platform successively; The travelling carriage that electric controller controls lifting platform by cable moves at lifting platform track upper-lower position, and the travelling carriage of translation stage moves at translation stage track right position; The travelling carriage of translation stage connects successively temp. controllable glass bottle holder and Dewar container for liquefied nitrogen bottle holder; When the invention process, placed temp. controllable vial, Dewar container for liquefied nitrogen bottle respectively above temp. controllable glass bottle holder and Dewar container for liquefied nitrogen bottle holder, and in temp. controllable vial and Dewar container for liquefied nitrogen bottle, water, liquid nitrogen are housed respectively; Aluminium chassis is as an installing rack, and aluminium chassis is connecting container seat, permanent magnet, electric controller, lifting pedestal and lifting platform positioning slide seat successively.
A kind of laser pre-polarizing xenon accumulation output device, it is characterized in that: a vacuum sleeve is housed in glass container, the gaseous xenon utilizing the vacuum in sleeve pipe interlayer to prevent to flow through is chilled on its inwall by liquid nitrogen temperature and blocks continuously flowing into of laser pre-polarizing gaseous xenon.
A kind of laser pre-polarizing xenon accumulation output device.It is characterized in that: vacuum sleeve and glass container are placed in container holder, glass container bottom is positioned at the center of permanent magnet, and there is the field region that permanent magnet produces.
A kind of laser pre-polarizing xenon accumulation output device, it is characterized in that: electric controller, lifting pedestal are connected by cable, during this device busy, electric controller controls lifting platform respectively travelling carriage by cable carries out moving up and down and moves left and right on translation stage track with the travelling carriage of translation stage on lifting platform track, controls Dewar container for liquefied nitrogen bottle thus, temp. controllable vial enters or shift out permanent magnet and be inserted in glass container interior.Be respectively laser pre-polarizing xenon in the field region that constant-temperature hot water in liquid nitrogen in Dewar container for liquefied nitrogen bottle, temp. controllable vial produces at permanent magnet to provide freezing and become solid-state or distillation becomes the temperature environment of gaseous state.
The present invention adopts following technical scheme and measure:
(1) electric lifting platform and a motorized precision translation stage are combinationally used, the Dewar container for liquefied nitrogen bottle that can control to be equipped with liquid nitrogen or the adjustable electrothermal bottle that constant-temperature hot water is housed as required timesharing are inserted in the glass container be positioned in the field region of permanent magnet;
(2) use a group permanent-magnet both for the solidification of laser pre-polarizing xenon and accumulation provide magnetic field environment, also for its distillation provides magnetic field environment (magnetic direction and magnetic field intensity);
(3) liquid nitrogen is used to provide temperature environment for other gas in the freezing solidification of laser pre-polarizing xenon and accumulation and separating mixed gas;
(4) constant-temperature hot water is used to provide temperature environment for the distillation of laser pre-polarizing solid xenon.
The workflow of this device is: first by glass processing mode successively welding L shape glass tube, vacuum sleeve, glass container, glass tube, second vacuum valve of the first vacuum valve according to standard; Again container holder, permanent magnet are respectively installed on aluminium chassis, allow container holder mesopore, the perforate of aluminium chassis upper end and permanent magnet upper end perforate three align; Then, allow the glass container including vacuum sleeve successively through the mesopore of container holder, the perforate of aluminium chassis upper end, permanent magnet upper end perforate and locating, the bottom simultaneously adjusting glass container is positioned at the center of permanent magnet; Electric controller is connecting cable and the lifting pedestal be arranged on aluminium chassis successively; Lifting platform track connects travelling carriage, translation stage track, the travelling carriage of translation stage, lifting platform positioning slide, lifting platform positioning slide seat, the aluminium chassis of lifting platform successively; The travelling carriage that electric controller controls lifting platform by cable moves at lifting platform track upper-lower position, and the travelling carriage of translation stage moves at translation stage track right position; The travelling carriage of translation stage connects successively temp. controllable glass bottle holder and Dewar container for liquefied nitrogen bottle holder; When the present invention works, placed temp. controllable vial, Dewar container for liquefied nitrogen bottle respectively above temp. controllable glass bottle holder and Dewar container for liquefied nitrogen bottle holder, and in temp. controllable vial and Dewar container for liquefied nitrogen bottle, water, liquid nitrogen are housed respectively; Aluminium chassis as an installing rack, connecting container seat, permanent magnet, electric controller, lifting pedestal and lifting platform positioning slide seat successively.
Then, a kind of laser pre-polarizing xenon accumulation output device is linked in laser pre-polarizing system, open arrival end vacuum valve and port of export vacuum valve, the travelling carriage controlling lifting platform is positioned at lifting platform track upper end, the travelling carriage controlling translation stage is positioned at translation stage track left end, the Dewar container for liquefied nitrogen bottle that liquid nitrogen is housed is positioned at permanent magnet center, and make glass container enter in Dewar container for liquefied nitrogen bottle, the immersing in liquid nitrogen due to Dewar container for liquefied nitrogen bottle makes glass container be in the temperature of liquid nitrogen.When laser pre-polarizing system running hours, laser pre-polarizing gaseous xenon constantly flows into apparatus of the present invention, and flowing into through arrival end vacuum valve becomes laser pre-polarizing solid xenon after glass container and increase in time and accumulating at once.When laser pre-polarizing system stalls, close arrival end vacuum valve, port of export vacuum valve is held open.Finally, control allows Dewar container for liquefied nitrogen bottle leave glass container, mobile temp. controllable vial is positioned at the center of permanent magnet, the constant-temperature hot water in temp. controllable vial is made to soak glass container, make the laser pre-polarizing solid xenon in glass container distil at once and become gaseous xenon, and flow out from apparatus of the present invention port of export vacuum valve.At this moment, laser pre-polarizing gaseous xenon still remains the thermal nonequilibrium nuclear spin polarization degree produced by laser pump (ing) and spin-exchange.
The present invention compared with prior art, has the following advantages and effect:
The feature that structure is simple, easy to operate, accumulation exports integration.Laser pre-polarizing xenon device provided by the invention, for lung and the brain magnetic resonance imaging of human body, has very important application prospect.It also can meet the requirement carrying out magnetic resonance and imaging research that other needs such as such as porous material, surface etc. use laser pre-polarizing gaseous xenon.Below imbody some:
(1) apparatus of the present invention structure is simple, and integrated design, includes the Cumulate Sum output function of laser pre-polarizing xenon;
(2) the present invention can make liquid nitrogen or constant-temperature hot water alternately mobile for soaking glass container by simple Electronic control, for solidification or distillation laser pre-polarizing xenon provide the temperature environment of requirement;
(3) the present invention only only used a group permanent-magnet, simultaneously for solidification or distillation laser pre-polarizing xenon provide the magnetic field environment (magnetic direction and magnetic field intensity) of requirement;
(4), when apparatus of the present invention and the system combined work of laser pre-polarizing xenon, the high polarizability of organism magnetic resonance imaging requirement and the laser pre-polarizing gaseous xenon of high yield can be provided;
Accompanying drawing explanation
Fig. 1 is a kind of laser pre-polarizing xenon accumulation output device schematic diagram.
Wherein: 1-first vacuum valve, 2-L shape glass tube, 3-glass tube, 4-second vacuum valve, 5-container holder, 6-aluminium chassis, 7-electric controller, 8-cable, 9-lifting platform track, the travelling carriage of 10-lifting platform, 11-glass container, 12-vacuum sleeve, 13-permanent magnet, 14-lifting platform positioning slide, 15-Dewar container for liquefied nitrogen bottle, 16-temp. controllable vial, 17-is elevated pedestal, 18-temp. controllable glass bottle holder, the travelling carriage of 19-translation stage, 20-Dewar container for liquefied nitrogen bottle holder, 21-translation stage track, 22-lifting platform positioning slide seat.
Fig. 2-Fig. 5 is that a kind of laser pre-polarizing xenon accumulation output device implements schematic diagram.
In figure: 7-electric controller represents power switch from top to bottom respectively, the travelling carriage upper-lower position of Electronic control 10-lifting platform moves, the travelling carriage right position of Electronic control 19-translation stage moves, LP-laser pre-polarizing xenon system, M-magnetic resonance imaging system; Solid circles-power supply closes, empty circles-power supply is opened, the direction of filled arrows-do not operate, hollow arrow-Electronic control movement.
Fig. 2 is embodied as power supply and opens, and the travelling carriage of Electronic control 10-lifting platform is positioned at 9-lifting platform track lower end, and the travelling carriage of Electronic control 19-translation stage is positioned at 21-translation stage track left end, has put into 15-Dewar container for liquefied nitrogen bottle and 16-temp. controllable vial.
Fig. 3 is embodied as power supply and opens, the travelling carriage of Electronic control 10-lifting platform is positioned at 9-lifting platform track upper end, the travelling carriage of Electronic control 19-translation stage is positioned at 21-translation stage track left end, 15-Dewar container for liquefied nitrogen bottle is positioned at 13-permanent magnet center, and 11-glass container is entered in 15-Dewar container for liquefied nitrogen bottle.16-adjustable temperature vial is positioned at the left end outside 13-permanent magnet.
Fig. 4 is embodied as power supply and opens, and the travelling carriage of Electronic control 10-lifting platform is positioned at 9-lifting platform track lower end, and the travelling carriage of Electronic control 19-translation stage is positioned at 21-translation stage track right-hand member.Here shown in is a transition operation, and implementation process normally forwards Fig. 5 duty by Fig. 3 to through Fig. 4.
Fig. 5 is embodied as power supply and opens, the travelling carriage of Electronic control 10-lifting platform is positioned at 9-lifting platform track upper end, the travelling carriage of Electronic control 19-translation stage is positioned at 21-translation stage track right-hand member, 16-temp. controllable vial is positioned at 13-permanent magnet center, and 11-glass container is entered in 16-temp. controllable vial.15-Dewar container for liquefied nitrogen bottle is positioned at the right-hand member outside 13-permanent magnet.
Detailed description of the invention
Embodiment 1:
Below in conjunction with Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, the present invention is described in further detail:
The material of each parts of a kind of laser pre-polarizing xenon accumulation output device, shape, structure and annexation are:
A kind of laser pre-polarizing xenon accumulation output device, is made up of the travelling carriage 10 of the first vacuum valve 1, L shape glass tube 2, glass tube 3, second vacuum valve 4, container holder 5, aluminium chassis 6, electric controller 7, cable 8, lifting platform track 9, lifting platform, glass container 11, vacuum sleeve 12, permanent magnet 13, lifting platform positioning slide 14, Dewar container for liquefied nitrogen bottle 15, temp. controllable vial 16, lifting pedestal 17, temp. controllable glass bottle holder 18, the travelling carriage 19 of translation stage, Dewar container for liquefied nitrogen bottle holder 20, translation stage track 21, lifting platform positioning slide seat 22.
Except aluminium chassis 6, other assembly is all arranged on aluminium chassis 6.It is characterized in that: the first vacuum valve 1 is connected successively L shape glass tube 2, glass container 11, vacuum sleeve 12, glass tube 3, second vacuum valve 4; Aluminium chassis 6 upper end is connected with container holder 5, permanent magnet 13 respectively; Then, allow the glass container 11 including vacuum sleeve 12 successively through the mesopore of container holder 5, aluminium chassis 6 upper end perforate and permanent magnet 13 upper end perforate, make the bottom of glass container 11 enter into the center of permanent magnet 13, there is the field region that permanent magnet 13 produces; Electric controller 7 is connecting cable 8 and the lifting pedestal 17 be arranged on aluminium chassis 6 successively; Lifting platform track 9 connects travelling carriage 10, translation stage track 21, the travelling carriage 19 of translation stage, lifting platform positioning slide 14, lifting platform positioning slide seat 22, the aluminium chassis 6 of lifting platform successively; Electric controller 7 controls lifting platform travelling carriage 10 by cable 8 moves at lifting platform track 9 upper-lower position, and the travelling carriage 19 of translation stage moves at translation stage track 21 right position; The travelling carriage 19 of translation stage connects successively temp. controllable glass bottle holder 18 and Dewar container for liquefied nitrogen bottle holder 20; When the invention process, temp. controllable glass bottle holder 18 and Dewar container for liquefied nitrogen bottle holder 20 placed temp. controllable vial 16, Dewar container for liquefied nitrogen bottle 15 above respectively, and in temp. controllable vial 16 and Dewar container for liquefied nitrogen bottle 15, water, liquid nitrogen are housed respectively; Aluminium chassis 6 is as an installing rack, and aluminium chassis 6 is connecting container seat 5, permanent magnet 13, electric controller 7, lifting pedestal 17 and lifting platform positioning slide seat 22 successively.
A kind of laser pre-polarizing xenon accumulation output device.It is characterized in that: a vacuum sleeve 12 is housed in glass container 11, the gaseous xenon utilizing the vacuum in vacuum sleeve 12 interlayer to prevent to flow through by liquid nitrogen temperature be chilled in its inwall blocks laser pre-polarizing gaseous xenon continuously flow into accumulation.
A kind of laser pre-polarizing xenon accumulation output device, it is characterized in that: vacuum sleeve 12 and glass container 11 are placed on container holder 5 li, glass container 11 bottom is positioned at the center of permanent magnet 13, and there is the field region that permanent magnet 13 produces.
A kind of laser pre-polarizing xenon accumulation output device, it is characterized in that: electric controller 7, lifting pedestal 17 are connected by cable 8, during this device busy, electric controller 7 carries out by the travelling carriage 10 that cable 8 controls lifting platform respectively the travelling carriage 19 moved up and down with translation stage and moves left and right on translation stage track 21 on lifting platform track 9, controls Dewar container for liquefied nitrogen bottle 20 thus, temp. controllable vial 16 enters or shift out permanent magnet 13 and be inserted in glass container 11 interior.Be respectively laser pre-polarizing xenon in the field region that the constant-temperature hot water of the liquid nitrogen that Dewar container for liquefied nitrogen bottle is 15 li, temp. controllable vial 16 li produces at permanent magnet 13 to provide freezing and become solid-state or distillation becomes the temperature environment of gaseous state.
Being described in detail as follows of its each parts:
First vacuum valve 1 is the arrival end valve that laser pre-polarizing gaseous xenon flows into apparatus of the present invention, and it is ultrahigh vacuum glass valve, and model is Kimble/kontesHI-VAC826651.When it is opened, make laser pre-polarizing gaseous xenon to enter apparatus of the present invention and through L-type glass tube 2, vacuum sleeve 12, to flow into glass container 11 li be solid-state by liquid nitrogen frozen; When it is closed, then the gaseous xenon of distillation is prevented to reflux.
The material of L shape glass tube 2 is PYREX glass, as the admission passage of laser pre-polarizing gaseous xenon.
Glass tube 3 employs and the identical material of L shape glass tube 2, and its effect is the output channel of laser pre-polarizing gaseous xenon.
Second vacuum valve 4 is port of export valves that laser pre-polarizing gaseous xenon flows out apparatus of the present invention, employ and the identical material of the first vacuum valve 1 and model, it is opened usually, and other gas controlling to be separated in mist flows into the output of air and laser pre-polarizing gaseous xenon.
Container holder 5 uses polytetrafluoroethylplastic plastic material, medium design has the hole of glass container 11 overall diameter that can coincide, its effect is location placing glass container 11, make the bottom of glass container 11 be positioned at permanent magnet 13 center and when switch first vacuum valve 1 and the second vacuum valve 4 held stationary.
Aluminium chassis 6 is installing racks of apparatus of the present invention, top center devise one with the hole of container holder 5 interstitial hole same diameter, the center of permanent magnet 13 is put into for allowing glass container 11 pass through, all component except aluminium chassis 6 itself is all arranged on aluminium chassis 6, is integrally formed gasifying device;
The effect of electric controller 7 (model is DK-ZX-2D) is followed successively by out or closes power supply, the travelling carriage 10 of Electronic control lifting platform and the travelling carriage 19 of translation stage from top to bottom.
Cable 8 electric controller 7 is controlled the signal of telecommunication to be provided to the travelling carriage 10 of Electronic control lifting platform and the travelling carriage 19 of translation stage through lifting pedestal 17.
Lifting platform track 9 is components of lifting platform (model PSA-11-Z), with the travelling carriage 10 of lifting platform with the use of, can move up and down.
The travelling carriage 10 of lifting platform is the components of lifting platform (model PSA-11-Z), is connected with translation stage track 21, and it to be controlled by cable 8 by electric controller 7 and drives translation stage track 21 to move up and down together.
Glass container 11 material is also PYREX glass, and it is for accumulation laser pre-polarizing xenon.
Vacuum sleeve 12 material is identical with glass container 11, its effect is the passage that laser pre-polarizing gaseous xenon enters glass container 11, in order to prevent the laser pre-polarizing gaseous xenon flowed through from being occurred by the problem that liquid nitrogen frozen can not continuously flow into accumulation on cannula center wall, between two tube layer of vacuum sleeve 12, take out 5 × 10
-7the high vacuum of Pa is for reducing liquid nitrogen temperature to the impact flowing into laser pre-polarizing gaseous xenon.
The model of permanent magnet 13 is YC100, pole piece spacing scope is 70-120mm, its effect is to provide one and determines magnetic field intensity and direction, magnetic field intensity scope is 0.2-0.5T, make in the process of the solid-state accumulation of laser pre-polarizing xenon or formation gaseous state, substantially nondestructively to preserve its height thermal nonequilibrium nuclear spin polarization degree, the top of permanent magnet 13 have one with the hole of center, aluminium chassis 6 top same size, for putting into glass container 11.
Lifting platform positioning slide 14 effect makes the travelling carriage 10 of Electronic control lifting platform held stationary in rising or decline process.
Dewar container for liquefied nitrogen bottle 15 uses the bilayer of customization centre silver-plated and evacuated vial, and overall diameter is 65-115mm, can put into permanent magnet 13 li, and the liquid nitrogen that temperature is 77K is housed during its work, for becoming solid-state by freezing for laser pre-polarizing xenon.
It is identical that material and the glass container 11 of temp. controllable vial 16 use, outer having heaters part and heat-insulation layer, overall diameter is all 65-115mm mutually with Dewar container for liquefied nitrogen bottle 15, the temp. controllable scope of water temperature during work: more than room temperature to 373K, provides the hot water desublimation laser pre-polarizing solid xenon of steady temperature.
Lifting pedestal 17 is components of lifting platform (model PSA-11-Z), is arranged on aluminium chassis 6, for fixing lifting platform track 9.
Temp. controllable glass bottle holder 18, uses aluminum alloy material to make, is arranged on the travelling carriage 19 of translation stage, provide the position of placing temp. controllable vial 16.
The travelling carriage 19 of translation stage is the components of translation stage (model PSA-11-X), is connected with translation stage track 21, is controlled to move left and right by cable 8 by electric controller 7.
Dewar container for liquefied nitrogen bottle holder 20 uses aluminum alloy material to make, and is arranged on the travelling carriage 19 of translation stage, provides the position of placing Dewar container for liquefied nitrogen bottle 15.
Translation stage track 21 is components of translation stage (model PSA-11-X), with translation stage 19 conbined usage, makes stable the moving left and right of translation stage 19.
Lifting platform positioning slide seat 22, for fixing lifting platform positioning slide 14, it is installed on aluminium chassis 6.
When implementing laser pre-polarizing xenon accumulation output device of the present invention (Fig. 2-Fig. 5), electric controller 7 is moved up and down by the travelling carriage 10 that cable 8 controls lifting platform respectively and moves left and right with the travelling carriage 19 of translation stage, and Dewar container for liquefied nitrogen bottle 15 or temp. controllable vial 16 enter permanent magnet 13 and be enclosed within outside glass container 11 thus.The constant-temperature hot water of the liquid nitrogen that Dewar container for liquefied nitrogen bottle is 15 li, temp. controllable vial 16 li is respectively laser pre-polarizing xenon and provides freezing and become solid-state or distillation becomes the environment of gaseous state.
According to Fig. 2, be embodied as power supply and open, the travelling carriage 10 of Electronic control lifting platform is positioned at lifting platform track 9 lower end, and the travelling carriage 19 of Electronic control translation stage is positioned at translation stage track 21 left end, has put into Dewar container for liquefied nitrogen bottle 15 and temp. controllable vial 16.
According to Fig. 3, be embodied as power supply to open, the travelling carriage 10 of Electronic control lifting platform is positioned at lifting platform track 9 upper end, the travelling carriage 19 of Electronic control translation stage is positioned at translation stage track 21 left end, Dewar container for liquefied nitrogen bottle 15 is positioned at permanent magnet 13 center, and glass container 11 is entered in Dewar container for liquefied nitrogen bottle 15.Adjustable temperature vial 16 is positioned at the left end outside permanent magnet 13.
According to Fig. 4, be embodied as power supply and open, the travelling carriage 10 of Electronic control lifting platform is positioned at lifting platform track 9 lower end, and the travelling carriage 19 of Electronic control translation stage is positioned at translation stage track 21 right-hand member.Here shown in is a transition operation, and implementation process normally forwards Fig. 5 duty by Fig. 3 to through Fig. 4.
According to Fig. 5, be embodied as power supply to open, the travelling carriage 10 of Electronic control lifting platform is positioned at lifting platform track 9 upper end, the travelling carriage 19 of Electronic control translation stage is positioned at translation stage track 21 right-hand member, temp. controllable vial 16 is positioned at permanent magnet 13 center, and glass container 11 is entered in temp. controllable vial 16.Dewar container for liquefied nitrogen bottle 15 is positioned at the right-hand member outside permanent magnet 13.
The workflow of apparatus of the present invention is: first the first vacuum valve 1 is connected successively L shape glass tube 2, glass container 11, vacuum sleeve 12, glass tube 3, second vacuum valve 4; Again container holder 5, permanent magnet 13 are connected respectively on aluminium chassis 6; Then, allow the glass container 11 including vacuum sleeve 12 successively through the mesopore of container holder 5, aluminium chassis 6 upper end perforate, permanent magnet 13 upper end perforate and make the bottom of glass container 11 enter into the center of permanent magnet 13; Electric controller 7 is connecting cable 8 and the lifting pedestal 17 be arranged on aluminium chassis 6 successively; Lifting platform track 9 connects travelling carriage 10, translation stage track 21, the travelling carriage 19 of translation stage, lifting platform positioning slide 14, lifting platform positioning slide seat 22, the aluminium chassis 6 of lifting platform successively; Electric controller 7 controls lifting platform travelling carriage 10 by cable 8 moves at lifting platform track 9 upper-lower position, and the travelling carriage 19 of translation stage moves at translation stage track 21 right position; The travelling carriage 19 of translation stage connects successively temp. controllable glass bottle holder 18 and Dewar container for liquefied nitrogen bottle holder 20; When the invention process, temp. controllable glass bottle holder 18 and Dewar container for liquefied nitrogen bottle holder 20 placed temp. controllable vial 16, Dewar container for liquefied nitrogen bottle 15 above respectively, and in temp. controllable vial 16 and Dewar container for liquefied nitrogen bottle 15, water, liquid nitrogen are housed respectively; Aluminium chassis 6 as an installing rack, connecting container seat 5, permanent magnet 13, electric controller 7, lifting pedestal 17 and lifting platform positioning slide seat 22 successively.
Then, laser pre-polarizing xenon accumulation output device is linked in laser pre-polarizing system LP, open the first vacuum valve 1 and the second vacuum valve 4, and power-on as shown in Figure 3, the travelling carriage 10 controlling lifting platform is positioned at lifting platform track 9 upper end, the travelling carriage 19 controlling translation stage is positioned at translation stage track 21 left end, the Dewar container for liquefied nitrogen bottle 15 that liquid nitrogen is housed is positioned at permanent magnet 13 center, make glass container 11 enter in Dewar container for liquefied nitrogen bottle 15, the immersing in liquid nitrogen due to Dewar container for liquefied nitrogen bottle 15 makes glass container 11 be in temperature close to 77K.And adjustable temperature vial 16 is the left end outside permanent magnet 13.When laser pre-polarizing system LP running hours, laser pre-polarizing gaseous xenon constantly flows into apparatus of the present invention, flow through the first vacuum valve 1, L shape glass tube 2, vacuum sleeve 12 successively, become laser pre-polarizing solid xenon at once after entering glass container 11 and increase in time and accumulating.When laser pre-polarizing system stalls, close the first vacuum valve 1, second vacuum valve 4 and be held open.Then, apparatus of the present invention are as Fig. 4 duty, the travelling carriage 19 that power-on controls translation stage is positioned at translation stage track 21 right-hand member, the travelling carriage 10 controlling lifting platform is positioned at lifting platform track 9 upper end, at this moment, Dewar container for liquefied nitrogen bottle 15 is positioned at the right-hand member outside permanent magnet 13, and temp. controllable vial 16 is positioned at the center of permanent magnet 13, the constant-temperature hot water of temp. controllable vial 16 li is made to soak glass container 11, make the laser pre-polarizing solid xenon in glass container 11 distil at once and become gaseous xenon, and flow over glass tube 3 and the second vacuum valve 4 from glass container 11, finally flow out apparatus of the present invention, at this moment, laser pre-polarizing gaseous xenon remains the thermal nonequilibrium nuclear spin polarization degree produced by laser pump (ing) and spin-exchange.
Below in conjunction with accompanying drawing 1,2, the present invention take working gas as xenon (1%)+helium (90%)+nitrogen (9%) mist (5atm) is example, is described in further detail laser pre-polarizing xenon accumulation output device of the present invention, implementation process:
In implementation process, first, by a kind of arrival end of the first vacuum valve 1 of laser pre-polarizing xenon accumulation output device and laser pre-polarizing system connectivity.Then, as shown in Figure 2, power-on, the travelling carriage 10 controlling lifting platform is positioned at the lower end of lifting platform track 9, and the travelling carriage 19 controlling translation stage is positioned at the left end of translation stage track 21, and the Dewar container for liquefied nitrogen bottle 15 that liquid nitrogen is housed is positioned at permanent magnet 13 lower end.Further, the first vacuum valve 1 and the second vacuum valve 4 is opened.As indicated at 3, the travelling carriage 10 controlling lifting platform is again positioned at the upper end of lifting platform track 9, the travelling carriage 19 controlling translation stage is positioned at the left end of translation stage track 21, the Dewar container for liquefied nitrogen bottle 15 that liquid nitrogen is housed is positioned at the 0.4T field region at permanent magnet 13 center, make glass container 11 enter in Dewar container for liquefied nitrogen bottle 15, the immersing in liquid nitrogen due to Dewar container for liquefied nitrogen bottle 15 makes glass container 11 be in temperature close to 77K.And adjustable temperature vial 16 is the left end outside permanent magnet 13.When laser pre-polarizing system running hours, xenon (1%)+helium (90%)+nitrogen (9%) mist through laser pump (ing) and spin-exchange constantly flows into apparatus of the present invention, flow through the first vacuum valve 1, L shape glass tube 2, vacuum sleeve 12 successively, laser pre-polarizing gaseous xenon enter be in ~ glass container 11 of 77K temperature after become solid xenon at once and increase in time and accumulating.And helium and nitrogen can not be cured at ~ 77K, therefore, they directly flow out apparatus of the present invention through glass tube 3 and the second vacuum valve 4.When laser pre-polarizing system LP quits work, close the first vacuum valve 1, allow the second vacuum valve 4 continue to be held open, and be linked in magnetic resonance imaging system M.Then, apparatus of the present invention forward duty as shown in Figure 5 from Fig. 3 duty to through Fig. 4 duty at once, the travelling carriage 19 that electric controller 7 controls translation stage is positioned at the right-hand member of translation stage track 21, the travelling carriage 10 controlling lifting platform is positioned at the upper end of lifting platform track 9, at this moment, Dewar container for liquefied nitrogen bottle 15 is positioned at the right-hand member outside permanent magnet 13, and temp. controllable vial 16 is positioned at the center of permanent magnet 13, the constant-temperature hot water of temp. controllable vial 16 li of 325K temperature is made to soak glass container 11, make the laser pre-polarizing solid xenon in glass container 11 distil at once and become gaseous xenon, and flow over glass tube 3 and the second vacuum valve 4 from glass container 11, finally flow out apparatus of the present invention to magnetic resonance imaging system M.At this moment, laser pre-polarizing xenon remains the thermal nonequilibrium nuclear spin polarization degree produced by laser pump (ing) and spin-exchange.
In the foregoing description of laser pre-polarizing xenon accumulation output device of the present invention, the mist of the xenon+helium+nitrogen being for working gas.When from laser pre-polarizing xenon system and through the xenon+helium+nitrogen of laser pump (ing) and spin-exchange, the glass container 11 that apparatus of the present invention are arranged in permanent magnet 13 center is entered by the first vacuum valve 1, wherein, helium and nitrogen can not become solid-state, directly flow in air through glass tube 3 and the second vacuum valve 4, and laser pre-polarizing xenon due in Dewar container for liquefied nitrogen bottle 15 ~ the acting as in order to solid xenon of 77K temperature.When laser pre-polarizing xenon system LP running hours, laser pre-polarizing xenon is constantly accumulated.When after laser pre-polarizing system stalls, the constant-temperature hot water being positioned at temp. controllable vial 16 li of 325K temperature at permanent magnet 13 center soaks glass container 11, laser pre-polarizing solid xenon is distilled and becomes gaseous xenon, then flow out from apparatus of the present invention, enter into magnetic resonance imaging system M.Because the mist of xenon+helium+nitrogen is through the separation of liquid nitrogen temperature, only laser pre-polarizing xenon becomes solid-state and obtains accumulation; Then, the effect distillation solid xenon of constant-temperature hot water becomes gaseous xenon.Liquid nitrogen, constant-temperature hot water and permanent magnet 13 amalgamation in magnetic field, makes the xenon flowing out laser pre-polarizing xenon accumulation output device of the present invention still remain height thermal nonequilibrium nuclear spin polarization degree.Apparatus of the present invention and laser pre-polarizing system LP conbined usage, the requirement of organism magnetic resonance imaging (imaging research of such as human lung and brain) for the high polarizability required for laser pre-polarizing xenon and high yield can be met, therefore, there is the prospect of important using value and potential application.
Claims (4)
1. the accumulation output device of a laser pre-polarizing xenon, it comprises the first vacuum valve (1), L shape glass tube (2), container holder (5), electric controller (7), lifting platform track (9), the travelling carriage (10) of lifting platform, lifting platform positioning slide (14), temp. controllable vial (16), the travelling carriage (19) of translation stage, translation stage track (21), it is characterized in that: the first vacuum valve (1) connects L shape glass tube (2), glass container (11), vacuum sleeve (12), glass tube (3), the second vacuum valve (4) successively; Aluminium chassis (6) upper end is connected with container holder (5), permanent magnet (13) respectively; The glass container (11) including vacuum sleeve (12) is successively through the mesopore of container holder (5), aluminium chassis (6) upper end perforate and permanent magnet (13) upper end perforate, and electric controller (7) is connecting cable (8) and the lifting pedestal (17) that is arranged on aluminium chassis (6) successively; Lifting platform track (9) connects travelling carriage (10), translation stage track (21), the travelling carriage (19) of translation stage, lifting platform positioning slide (14), lifting platform positioning slide seat (22), the aluminium chassis (6) of lifting platform successively; The travelling carriage (19) of translation stage connects successively temp. controllable glass bottle holder (18) and Dewar container for liquefied nitrogen bottle holder (20); Temp. controllable glass bottle holder (18) and Dewar container for liquefied nitrogen bottle holder (20) placed temp. controllable vial (16), Dewar container for liquefied nitrogen bottle (15) above respectively, and aluminium chassis (6) is connecting container seat (5), permanent magnet (13), electric controller (7), lifting pedestal (17) and lifting platform positioning slide seat (22) successively.
2. the accumulation output device of a kind of laser pre-polarizing xenon according to claim 1, is characterized in that: described glass container (11) is inner is equipped with a vacuum sleeve (12).
3. the accumulation output device of a kind of laser pre-polarizing xenon according to claim 1, it is characterized in that: it is inner that described glass container (11) and vacuum sleeve (12) are placed on container holder (5), and glass container (11) bottom is positioned at the center of permanent magnet (13).
4. the accumulation output device of a kind of laser pre-polarizing xenon according to claim 1, is characterized in that: electric controller (7), lifting pedestal (17) are connected by cable (8).
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| JPH11123767A (en) * | 1997-10-21 | 1999-05-11 | Ebara Corp | Light shaping device |
| US6454141B1 (en) * | 2001-07-25 | 2002-09-24 | Coulter International Corp. | Non-pressurized dry powder dispensing apparatus |
| CN1524620A (en) * | 2003-09-16 | 2004-09-01 | 中国科学院武汉物理与数学研究所 | Laser polarization **Xe solid memory |
| CN101634651A (en) * | 2008-07-25 | 2010-01-27 | 中国科学院大连化学物理研究所 | Multiphase catalytic reaction device for testing in situ solid-state nuclear magnetic resonance |
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| JPH11123767A (en) * | 1997-10-21 | 1999-05-11 | Ebara Corp | Light shaping device |
| US6454141B1 (en) * | 2001-07-25 | 2002-09-24 | Coulter International Corp. | Non-pressurized dry powder dispensing apparatus |
| CN1524620A (en) * | 2003-09-16 | 2004-09-01 | 中国科学院武汉物理与数学研究所 | Laser polarization **Xe solid memory |
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Effective date of registration: 20180518 Address after: 430000 318 Friendship Avenue, Wuchang District, Wuhan, Hubei. Patentee after: Wuhan Zhongke polarization Medical Technology Co., Ltd. Address before: 430071 Hongshan West District, Wuchang, Wuhan, Hubei Province, No. 30 Patentee before: Wuhan Inst. of Physics and Mathematics, Chinese Academy of Sciences |