Use freezing and drying lyophilization is prepared Chinese medicinal granule equipment and is prepared the method for Chinese medicinal granule
Technical field
The present invention relates to Chinese medicine preparation equipment and method, particularly relate to a kind of material suitability wider, the Preparation equipment of the Chinese medicine granules that adjuvant dependency is lower and method.
Background technology
Chinese medicinal granule is a kind of conventional Chinese medicine preparation, has taking convenience, absorbs soon, stores and transport simple feature.The traditional processing technology of Chinese medicine granules, generally first uses the method such as decoctions to extract purification to crude drug concentrated, obtains preparing the required fluid extract of granule or extractum, then utilization extrude sieve, the method such as fluidized drying granulates.In addition, Chinese medicinal granule also can, through further processing, be prepared other as tablet, and the medicine of other dosage form such as capsule, applies very extensive.
Based on the sticky nature of extractum, be shaped for granulating and ensure product dissolution, current Chinese medicinal granule preparation all can be added a large amount of adjuvants and mix, for example: filler (diluent), binding agent, disintegrating agent etc. in the concentrated Chinese medical concrete making.And the content of these adjuvants accounts for granule composition more than 50% conventionally.Fluidized drying granulation technique has been owing to having adopted spray-fluidized mode, make adjuvant content relatively tradition sieve to granulate and decrease, but still adjuvant has been kept to certain dependency, the granule adjuvant content making is not less than 30% conventionally.High adjunct content causes the expensive and loaded down with trivial details operation of medicine, and material, production hour, equipment, energy resource consumption and quality testing aspect drop into larger, and clothes for patients consumption is large.
For the product that contains volatile oil component, often need to be prepared into tincture, or tincture soft capsule, increase the difficulty of carrying and taking; Be prepared into granule, deposit and be easy to during the course volatilization, the problem that drug effect reduces, and the method for the heating fluidized granulation that wet granulation generally adopts at present, owing to there being the process of heating, more increased the loss of volatile oil component.
At present Chinese medicine granules dry conventional be heating process, but owing to conventionally containing polysaccharose substance in Chinese medicine extract, make Chinese medical concrete under sticky state more difficult dry under heated condition, easily harden, coking, therefore need to add a large amount of adjuvants and improve granulation drying and moulding and dispersive property.
How to find a kind of adjuvant dependency lower, the scope of application is wider, applicable to Chinese medicinal granule Preparation equipment and the method for processing volatile oil component, has become the problem that development Chinese medicinal granule new preparation process merits attention.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of and use freezing granulation seasoning to prepare the equipment of Chinese medicinal granule.
Second object of the present invention is to provide a kind of method that uses freezing and drying lyophilization to prepare Chinese medicinal granule.
The 3rd object of the present invention is to provide the second and uses freezing granulation seasoning to prepare the equipment of Chinese medicinal granule.
The 4th object of the present invention is to provide the second and uses freezing and drying lyophilization to prepare the method for Chinese medicinal granule.
Technical scheme of the present invention is summarized as follows:
Use freezing granulation seasoning to prepare an equipment for Chinese medicinal granule, comprise freezing cabin 1, shower nozzle 2, fluidisation air distribution plate 3, exhaust system 4, vibrating device 5 and Frozen Medium bucket 8; Freezing cabin 1 is made up of cover 11 and hold 12; Cover 11 and hold 12 are flexibly connected; The top of cover 11 is provided with circular hole 13; The shower nozzle 2 that is connected with vibrating device 5 is arranged on directly over circular hole; Cover 11 is connected with exhaust system 4; Fluidisation air distribution plate 3 is arranged on hold 12 middle and lower parts; Shower nozzle is connected with material barrel by pipeline, and hold 12 bottoms are connected with Frozen Medium bucket 8 by pipeline, and the top of Frozen Medium bucket 8 is provided with Frozen Medium inlet/outlet pipe 9 and gases at high pressure enter pipe 10.
Outer surface at shower nozzle is preferably provided with heat-insulation layer.
Use freezing and drying lyophilization to prepare a method for Chinese medicinal granule, comprise the steps:
1) prepare a kind ofly to use freezing granulation seasoning to prepare the equipment of Chinese medicinal granule;
2) liquid Frozen Medium is inputted by pipeline by Frozen Medium bucket 8 in the hold 12 in freezing cabin 1 and made liquid Frozen Medium liquid level higher than fluidisation air distribution plate 3, by fluid Chinese medicine material or semifluid Chinese medicine material, under the condition that is 1~10bar at discharge pressure, be delivered in shower nozzle 2, under the condition that is 20Hz~20000Hz in the vertical vibration frequency of vibrating device 5, make the nozzle ejection of material from shower nozzle, be dropped in liquid Frozen Medium by covering the circular hole 13 at 11 tops, under normal pressure, be solidified into granule, and part Frozen Medium is gasified, the Frozen Medium of gasification is discharged by exhaust system 4, the interior liquid Frozen Medium of interior Frozen Medium bucket 8 liquid Frozen Medium and freezing cabin 1 is extracted out by Frozen Medium inlet/outlet pipe 9,
3) compressed nitrogen or compressed air are entered to pipe 10 with 3-20bar input Frozen Medium bucket 8 from gases at high pressure, after Frozen Medium bucket 8 bufferings, input in freezing cabin 1, compressed nitrogen after buffering or compressed air are from bottom to top by fluidisation air distribution plate 3, make to be deposited in the step 2 on fluidisation air distribution plate 3) in institute the granule that obtains in boiling fluidized state, until particle drying.
The second uses freezing granulation seasoning to prepare the equipment of Chinese medicinal granule, comprises freezing cabin 1, shower nozzle 2, fluidisation air distribution plate 3, exhaust system 4, vibrating device 5 and Frozen Medium bucket 8; Freezing cabin 1 is made up of cover 11 and hold 12; Cover 11 and hold 12 are flexibly connected; The top of cover 11 is provided with circular hole 13; Shower nozzle 2 comprises multiple nozzles that form by central canal 14 with the concentric trocar sheath 15 of central canal, and the shower nozzle 2 that is connected with vibrating device 5 is arranged on directly over circular hole; Cover 11 is connected with exhaust system 4; Fluidisation air distribution plate 3 is arranged on hold 12 middle and lower parts; The central canal of each nozzle of shower nozzle is connected from different material barrels by pipeline respectively with trocar sheath, and hold 12 bottoms are connected with Frozen Medium bucket 8 by pipeline, and the top of Frozen Medium bucket 8 is provided with Frozen Medium inlet/outlet pipe 9 and gases at high pressure enter pipe 10.
Outer surface at shower nozzle is preferably provided with heat-insulation layer.
The second uses freezing and drying lyophilization to prepare the method for Chinese medicinal granule, comprises the steps:
1) preparing the second uses freezing granulation seasoning to prepare the equipment of Chinese medicinal granule;
2) liquid Frozen Medium is inputted by pipeline by Frozen Medium bucket 8 in the hold 12 in freezing cabin 1 and made liquid Frozen Medium liquid level higher than fluidisation air distribution plate 3, by fluid Chinese medicine material or semifluid Chinese medicine material, under the condition that is 1~10bar at discharge pressure, be delivered in the trocar sheath 15 of each nozzle, simultaneously, by one other fluid Chinese medicine material or semifluid Chinese medicine material, be that 1~10bar is delivered in the central canal 14 of each nozzle at discharge pressure, under the condition that is 20Hz~20000Hz in the vertical vibration frequency of vibrating device 5, make material spray from trocar sheath 15 and central canal 14, be dropped in liquid Frozen Medium by covering the circular hole 13 at 11 tops, under normal pressure, be solidified into granule, and part Frozen Medium is gasified, the Frozen Medium of gasification is discharged by exhaust system 4, the interior liquid Frozen Medium of interior Frozen Medium bucket 8 liquid Frozen Medium and freezing cabin 1 is extracted out by Frozen Medium inlet/outlet pipe 9,
3) compressed nitrogen or compressed air are entered to pipe 10 with 3-20bar input Frozen Medium bucket 8 from gases at high pressure, after Frozen Medium bucket 8 bufferings, input in freezing cabin 1, compressed nitrogen after buffering or compressed air are from bottom to top by fluidisation air distribution plate 3, make to be deposited in the step 2 on fluidisation air distribution plate 3) in institute the granule that obtains in boiling fluidized state, until particle drying.
Advantage of the present invention:
1) changing droplet thermal curing methods is freezing solidifying, thereby overcome in existing Chinese medicinal granule production technology, the high shortcoming of adjuvant dependency is obtained to zero product to low adjuvant content.
2) utilize common extract to be easy to curing feature compared with volatile oil, use multilamellar shower nozzle, make outer extract wrapping inner layer volatile oil, reduce volatile oil loss in process of production.
3) freezing vibration spraying solidifying with fluidized drying combined, provide a kind of particle diameter control more even, particle shape is more regular, the better freezing granulation of mobility and integrated equipment.
4) the Chinese medicine microparticle obtaining in said process, adjuvant content is low, even particle size distribution, good fluidity, more be convenient to later use fluidized coating technology, granule is carried out to effective ingredient weightening finish, slow controlled release or enteric coating, and this is also for the administration number of times and the dosage that further reduce medicine provide the foundation.And Frozen Medium used in the present invention, volatilization rapidly at normal temperatures, nontoxic residue-free, has also avoided follow-up except Frozen Medium operation, and making to proceed follow-up fluidized coating in an equipment becomes possibility.
Brief description of the drawings
Fig. 1 is a kind of device structure schematic diagram that uses freezing granulation seasoning to prepare Chinese medicinal granule of the present invention.
Fig. 2 is that the second of the present invention uses freezing granulation seasoning to prepare the device structure schematic diagram of Chinese medicinal granule.
Fig. 3 is the structural representation that equipment connection that the second of the present invention uses freezing granulation seasoning to prepare Chinese medicinal granule has material barrel.
Detailed description of the invention
The present invention is further illustrated for accompanying drawing below.
Use freezing granulation seasoning to prepare an equipment (see figure 1) for Chinese medicinal granule, comprise freezing cabin 1, shower nozzle 2, fluidisation air distribution plate 3, exhaust system 4, vibrating device 5 and Frozen Medium bucket 8; Freezing cabin 1 is made up of cover 11 and hold 12; Cover 11 and hold 12 are flexibly connected; The top of cover 11 is provided with circular hole 13; The shower nozzle 2 that is connected with vibrating device 5 is arranged on directly over circular hole; Cover 11 is connected with exhaust system 4; Fluidisation air distribution plate 3 is arranged on hold 12 middle and lower parts; Shower nozzle is connected with material barrel by pipeline, and hold 12 bottoms are connected with Frozen Medium bucket 8 by pipeline, and the top of Frozen Medium bucket 8 is provided with Frozen Medium inlet/outlet pipe 9 and gases at high pressure enter pipe 10.
Outer surface at shower nozzle is preferably provided with heat-insulation layer.
Use freezing and drying lyophilization to prepare a method for Chinese medicinal granule, comprise the steps:
1) prepare a kind ofly to use freezing granulation seasoning to prepare the equipment of Chinese medicinal granule;
2) liquid Frozen Medium is inputted by pipeline by Frozen Medium bucket 8 in the hold 12 in freezing cabin 1 and made liquid Frozen Medium liquid level higher than fluidisation air distribution plate 3, by fluid Chinese medicine material or semifluid Chinese medicine material, under the condition that is 5bar at discharge pressure, be delivered in shower nozzle 2, under the condition that is 10000Hz in the vertical vibration frequency of vibrating device 5, make the nozzle ejection of material from shower nozzle, be dropped in liquid Frozen Medium by covering the circular hole 13 at 11 tops, under normal pressure, be solidified into granule, and part Frozen Medium is gasified, the Frozen Medium of gasification is discharged by exhaust system 4, the interior liquid Frozen Medium of interior Frozen Medium bucket 8 liquid Frozen Medium and freezing cabin 1 is extracted out by Frozen Medium inlet/outlet pipe 9,
Discharge pressure can also be selected arbitrarily to regulate between 1-10bar;
The vertical vibration frequency of vibrating device 5 can also, according to product difference, be set as the optional frequency between 20-20000Hz;
3) compressed nitrogen or compressed air are entered to pipe 10 with 10bar input Frozen Medium bucket 8 from gases at high pressure, after Frozen Medium bucket 8 bufferings, input in freezing cabin 1, compressed nitrogen after buffering or compressed air are from bottom to top by fluidisation air distribution plate 3, make to be deposited in the step 2 on fluidisation air distribution plate 3) in institute the granule that obtains in boiling fluidized state, the rapid sublimation drying of moisture in granule, until particle drying forms the dried particles of fluffy structure.
Compressed nitrogen or compressed air enter the pressure of pipe 10 input Frozen Medium buckets 8 from gases at high pressure can also be according to product difference, is set as any force value in 3-20bar.
The second uses freezing granulation seasoning to prepare the equipment of Chinese medicinal granule (seeing Fig. 2 and Fig. 3), comprises freezing cabin 1, shower nozzle 2, fluidisation air distribution plate 3, exhaust system 4, vibrating device 5 and Frozen Medium bucket 8; Freezing cabin 1 is made up of cover 11 and hold 12; Cover 11 and hold 12 are flexibly connected; The top of cover 11 is provided with circular hole 13; Shower nozzle 2 comprises multiple nozzles that form by central canal 14 with the concentric trocar sheath 15 of central canal, and the shower nozzle 2 that is connected with vibrating device 5 is arranged on directly over circular hole; Cover 11 is connected with exhaust system 4; Fluidisation air distribution plate 3 is arranged on hold 12 middle and lower parts; The central canal of each nozzle of shower nozzle is connected from different material barrels 6 and 7 by pipeline respectively with trocar sheath, and hold 12 bottoms are connected with Frozen Medium bucket 8 by pipeline, and the top of Frozen Medium bucket 8 is provided with Frozen Medium inlet/outlet pipe 9 and gases at high pressure enter pipe 10.
Outer surface at shower nozzle is preferably provided with heat-insulation layer.
The second uses freezing and drying lyophilization to prepare the method for Chinese medicinal granule, comprises the steps:
1) select the second to use freezing granulation seasoning to prepare the equipment of Chinese medicinal granule;
2) liquid Frozen Medium is inputted by pipeline by Frozen Medium bucket 8 in the hold 12 in freezing cabin 1 and made liquid Frozen Medium liquid level higher than fluidisation air distribution plate 3, by fluid Chinese medicine material or semifluid Chinese medicine material, under the condition that is 5bar at discharge pressure, be delivered in the trocar sheath 15 of each nozzle, simultaneously, by one other fluid Chinese medicine material or semifluid Chinese medicine material, be that 50bar is delivered in the central canal 14 of each nozzle at discharge pressure, under the condition that is 10000Hz in the vertical vibration frequency of vibrating device 5, make material spray from trocar sheath 15 and central canal 14, be dropped in liquid Frozen Medium by covering the circular hole 13 at 11 tops, under normal pressure, be solidified into granule, and part Frozen Medium is gasified, the Frozen Medium of gasification is discharged by exhaust system 4, the interior liquid Frozen Medium of interior Frozen Medium bucket 8 liquid Frozen Medium and freezing cabin 1 is extracted out by Frozen Medium inlet/outlet pipe 9,
Discharge pressure can also be according to product difference, is set as any force value in 1-10bar;
The vertical vibration frequency of vibrating device 5 can also, according to different of product, be set as the optional frequency in 20-20000Hz;
3) compressed nitrogen or compressed air are entered to pipe 10 from gases at high pressure, with 6bar input Frozen Medium bucket 8, after Frozen Medium bucket 8 bufferings, input in freezing cabin 1, compressed nitrogen after buffering or compressed air are from bottom to top by fluidisation air distribution plate 3, make to be deposited in the step 2 on fluidisation air distribution plate 3) in institute the granule that obtains in boiling fluidized state, the rapid sublimation drying of moisture in granule, until particle drying forms the dried particles of fluffy structure.
Compressed nitrogen or compressed air enter the pressure of pipe 10 input Frozen Medium buckets 8 from gases at high pressure, according to product difference, can also be set as any pressure in 3-20bar.
The first material barrel 6, the structure of the second material barrel 7 and Frozen Medium bucket 8 can be identical, top comprises the pipeline (for input or extraction material/Frozen Medium) that reaches drum head, pressure-air input port, and pneumostome (can be according to technique needs, select directly to communicate with indoor, or connection respiratory organ, wherein Frozen Medium bucket 8 is placed on liftable platform, and position is adjustable, utilizes law of connected vessels control Frozen Medium liquid level (liquid level can obtain according to technology Calculation) with freezing chamber;
The effect of fluidisation air distribution plate 3: for air-flow is uniformly distributed, to obtain good fluidisation operating mode; The bed bed of material of supported in rest; And formation gas-flow resistance, maintain the stable of fluidized-bed layer.
The fluidisation air distribution plate form of industrial fluidized bed upper employing is at present more, and common air distribution plate type is once-through type air distribution plate and side-flow type air distribution plate, and wherein, side-flow type air distribution plate can be divided into again funnel-cap type, punching type and combination type.Above-mentioned industrial conventional all kinds of air distribution plate forms at present, all applicable to this equipment.
The outer surface of shower nozzle is provided with heat-insulation layer, makes Chinese medicine material in the time spraying, and is not subject to the temperature radiation impact of cryogenic freezing medium in freezing cabin.
The configurable automation control system of equipment of the present invention makes respectively suddenly can under setup parameter, automatically move step by step.