CN103736140B - A kind of medical dressing hydrogel compound fabric and its preparation method and application - Google Patents
A kind of medical dressing hydrogel compound fabric and its preparation method and application Download PDFInfo
- Publication number
- CN103736140B CN103736140B CN201410013667.5A CN201410013667A CN103736140B CN 103736140 B CN103736140 B CN 103736140B CN 201410013667 A CN201410013667 A CN 201410013667A CN 103736140 B CN103736140 B CN 103736140B
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- China
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- compound fabric
- preparation
- medical dressing
- gossypin
- hydrogel compound
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- 239000004744 fabric Substances 0.000 title claims abstract description 73
- 150000001875 compounds Chemical class 0.000 title claims abstract description 72
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 69
- 239000000243 solution Substances 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 19
- SJRXVLUZMMDCNG-UHFFFAOYSA-N Gossypin Natural products OC1C(O)C(O)C(CO)OC1OC1=C(O)C=C(O)C2=C1OC(C=1C=C(O)C(O)=CC=1)=C(O)C2=O SJRXVLUZMMDCNG-UHFFFAOYSA-N 0.000 claims abstract description 18
- SJRXVLUZMMDCNG-KKPQBLLMSA-N gossypin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(O)C=C(O)C2=C1OC(C=1C=C(O)C(O)=CC=1)=C(O)C2=O SJRXVLUZMMDCNG-KKPQBLLMSA-N 0.000 claims abstract description 18
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- 230000000977 initiatory effect Effects 0.000 claims abstract description 14
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003999 initiator Substances 0.000 claims abstract description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 11
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- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 5
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- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 10
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- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 6
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
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- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
- C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
- C08F251/02—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof on to cellulose or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/04—Alginic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/02—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to polysaccharides
Abstract
The present invention relates to a kind of medical dressing hydrogel compound fabric and its preparation method and application, belong to Chinese medicine preparation and preparation method thereof technical field.Preparation method, comprising: by NIPA and initiator dissolution with solvents, with nitrogen gas foaming; Gossypin carries out initiation reaction in initiator solution; Through the gossypin of initiation reaction after NIPA and dimethyl formamide mixed solution soak, polyreaction under a nitrogen atmosphere, obtains poly-N-isopropyl acrylamide-gossypin; Poly-N-isopropyl acrylamide-gossypin and alginate are dissolved in distilled water, form the hydrosol on top layer, and low pressure Rotary Evaporators removes solvent, obtains medical dressing hydrogel compound fabric.Have mechanical strength high, have antibacterial, antiinflammatory, hemostasis, intelligent control humidity, to keep skin surface moistening, prevents fabric and cambium adhesion, effectively promotes the advantage of histiocyte epithelization and wound healing.
Description
Technical field
The invention belongs to Chinese medicine preparation and preparation method thereof technical field, be specifically related to a kind of medical dressing hydrogel compound fabric and its preparation method and application, be mainly used in hemostasis and the tissue repair of various acute and chronic wound.
Background technology
Local wound and cause hemorrhage, infect, ulcer is a kind of commonly seen injuries, malpractice often causes wound inflammation, suppuration, even infects ulcer.Traditional method generally adopts sterile gauze and topical antibiotic medicine to process.Traditional gauze class dressing cannot keep wound surface moistening, hinders histiocyte epithelization, and wound healing postpones; Dressing fiber easily comes off, and causes foreign body reaction, impact healing; Wound granulation is organized in the mesh of dressing of easily growing into and is sticked together, and usually destroy newborn epithelium and granulation tissue when changing dressings, cause bleeding, this is not only unfavorable for the healing of wound, and makes Principle of Pain unbearably; Water absorption is not strong, and haemostatic effect is not good enough, and pathogen is easily through gauze infected wound; Workload of changing dressings is large.
Hydrogel is by the macromole with three-D space structure formed cross-linked between molecule by hydrophilic macromolecular compounds.Because the high molecular peculiar hydrophilic-structure of hydrogel, a large amount of moisture can be adsorbed and is retained in hydrogel structure, therefore has good absorb subsemimodule.Find that moist environmental benefits is since wound healing from British scientist GeorgeWinter in 1962, various new-type dressing obtained and developed widely half a century in the past, as aerogel dressing, bearing hydrocolloid dressing, minerals dressing and nanotechnology dressing etc.Compared with other dressing, aerogel dressing has unique advantage, and aerogel dressing can prevent excessive the scattering and disappearing of moisture and body fluid and play the effect of hemostasis; There is good permeability to water and oxygen and do not allow antibacterial to pass through, the invasion of antibacterial can be resisted, and the growth of anti-bacteria, there is function that is antibacterial, antiinflammatory; Can close well with wound surface note, but secondary damage can not be carried out with wound surface adhesion with free of replacement dressing belt; Moisture-inhibiting, breathe freely and make wound surface be in moistening but not have the environment of hydrops, good biocompatibility, has the function that can promote wound healing, is more and more subject to the attention of various countries.As the people such as Yang Qing (Yang Qing, Wu Ying, Zhang Yueting. a kind of medical chitosan transparent hydrogel wound dressing and Synthesis and applications thereof: 20091004724.5 [P] .2009-3-13) disclose a kind of medical chitosan transparent hydrogel wound dressing and Synthesis and applications thereof.They are by preparation chitosan serosity, polyvinyl pyrrolidone PVP solution and acid polyethylene sodium solution, and mixing adds initiator and cross-linking agent, pours mould into, primary product are obtained by reacting at 40-75 DEG C of temperature, antiseptic is added on surface, dries, and cutting is packed and be get final product.But it exists the defect of bad mechanical strength, often need during application to fix, bring inconvenience.
Summary of the invention
Hydrogel can be divided into chemical gel and physical gel according to cross-linked mode difference.The polymer molecular chain of chemical gel is by covalent linkage, and physical gel is then combined by non-covalent bonds such as hydrogen bond, ionization and hydrophobicity effects.The water sorption of hydrogel and the composition of polymer, kind, link density and ambient temperature, acid-base value, ionic strength have substantial connection.The granular size of hydrogel, the size of contained micropore also have impact to the speed of water suction in addition.Common hydrogel has poly hydroxy ethyl acrylate, polyhydroxypropyl acrylate, polypyrrole alkane ketone, polyacrylic acid and polyacrylamide etc.
Based on the temperature sensitive intelligent hydrogel of NIPA, it is a kind of typical thermal shrinkage type temperature-sensitive hydrogel, the change of its response environment temperature and occur swelling or shrink, minimum critical solution temperature is at about 32 DEG C, close to people's shell temperature, can be used as the tissue repair that medical dressing is widely used in body surface wound.Chitosan has bright significant bacteriostasis, and the skin bacterium such as staphylococcus aureus, bacillus pyocyaneus and the streptococcus pyogenes etc. that exist for general human epidermal all have obvious inhibitory action.Meanwhile, chitosan can promote epithelial regeneration, the speed of accelerating wound, improves the quality of wound healing.Chitosan can be degraded into oligosaccharide, oligosaccharide even monosaccharide, is conducive to accelerating cell proliferation and strengthening tissue remodeling.And each tool advantage of chitosan of different molecular weight size, it is good that the chitosan of macromolecule has film strength, and the chitosan of small-molecular-weight has that biological activity is high, the feature of good water-retaining property, and both uses can the excellent medical dressing of processability.
The object of the invention is to disclose a kind of medical dressing hydrogel compound fabric; Compared with other dressing, hydrogel compound fabric has unique advantage as medical dressing, and aerogel dressing can prevent excessive the scattering and disappearing of moisture and body fluid and play the effect of hemostasis; There is good permeability to water and oxygen and do not allow antibacterial to pass through, the invasion of antibacterial can be resisted, and the growth of anti-bacteria, there is function that is antibacterial, antiinflammatory; Can close well with wound surface note, but secondary damage can not be carried out with wound surface adhesion with free of replacement dressing belt; Moisture-inhibiting, breathe freely and make wound surface be in moistening but not have the environment of hydrops, good biocompatibility, has the function that can promote wound healing.
Second object of the present invention is the preparation method disclosing above-mentioned medical dressing hydrogel compound fabric.
3rd object of the present invention is that disclosing above-mentioned medical dressing hydrogel compound fabric is preparing the application in anti-inflammation and haemostatic medicament; Above-mentioned medical dressing hydrogel compound fabric is as dressing, and the common drug of some anti-inflammations and hemostasis, if Butyl Flufenamate Ointment, matrine or berberine hydrochloride etc. are as active component.
The object of the invention is to be achieved through the following technical solutions:
A preparation method for medical dressing hydrogel compound fabric, comprises the steps:
(1), by NIPA and initiator dissolution with solvents, with nitrogen gas foaming; Described initiator is selected from the one in ammonium ceric nitrate and Ammonium persulfate.;
(2) the initiator solution initiation reaction 15min that 200mg gossypin 10mL concentration is 10 ~ 20mM, is taken;
(3), using 25mLN-N-isopropylacrylamide and 1.2g be dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent, obtain NIPA and dimethyl formamide mixed solution;
(4), in step (2) after the gossypin of initiation reaction soaks 30min in the solution of 5mL step (3), to be laid on dry glass plate polyreaction 48h under a nitrogen atmosphere, to obtain poly-N-isopropyl acrylamide-gossypin;
(5) poly-N-isopropyl acrylamide-gossypin, prepared and alginate are dissolved in distilled water, form the hydrosol on top layer, and low pressure Rotary Evaporators removes solvent, obtains medical dressing hydrogel compound fabric.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, in step (1), the volume ratio of NIPA is 25% ~ 50%, and the mass volume ratio of initiator is 2% ~ 5%.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, the concrete steps of step (1) are: by 0.4g ammonium ceric nitrate, and 25mLN-N-isopropylacrylamide and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, use nitrogen gas foaming.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, the concrete steps of step (1) are: by 0.2g Ammonium persulfate., and 25mLN-N-isopropylacrylamide and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, use nitrogen gas foaming.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, the alginate in step (5) is sodium alginate or calcium alginate.
A kind of medical dressing hydrogel compound fabric, wherein, described medical dressing hydrogel compound fabric is prepared by the preparation method described in technique scheme.
A kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, in medical dressing hydrogel compound fabric, the content of NIPA is mass percent 6% ~ 30%.
A kind of medical dressing hydrogel compound fabric is preparing the application in anti-inflammation and haemostatic medicament, described anti-inflammation and haemostatic medicament are made up of dressing and active component, wherein, described active component is Butyl Flufenamate Ointment, matrine or berberine hydrochloride, and described dressing is the medical dressing hydrogel compound fabric described in technique scheme.
A kind of medical dressing hydrogel compound fabric described in technique scheme is preparing the application in anti-inflammation and haemostatic medicament, and wherein, the mass percent that active component accounts for medicine is 2% ~ 5%.
The present invention has following beneficial effect:
1, medical dressing hydrogel compound fabric of the present invention adopts natural Biodegradable macromolecular material, has certain antimicrobial and anti-inflammation efficacy, good biocompatibility, greatly reduces the risk of immunological rejection.
2, medical dressing hydrogel compound fabric of the present invention adds medicine, as Butyl Flufenamate Ointment, matrine and berberine hydrochloride etc., hydrogel compound fabric is made to have the function of good antibacterial, antiinflammatory, hemostasis and promotion wound healing, the infection avoided external environment and change dressings in process; Meanwhile, the absorb subsemimodule of hydrogel compound fabric is good, for wound creates a wet environment, is conducive to wound healing and changes dressings.
3, medical dressing hydrogel compound fabric of the present invention is Thermo-sensitive " intelligence " material, and by the change of shell temperature, swelling or contraction, can make sustained release, drug effect cycle stretch-out, reduce the frequency of changing dressings, and workload reduces.
4, the preparation process of medical dressing hydrogel compound fabric of the present invention is simple, and agents useful for same and raw material all commercially, can continuous seepage.
Accompanying drawing illustrates:
Fig. 1 is hydrogel compound fabric at the Swelling Dynamics curve of 37 DEG C;
Fig. 2 is rat skin pathological section (a is model group, and b is normal group, and c is positive controls, and d is common gauze and combination therapies group, and e is not pastille hydrogel compound fabric group, and f is pastille hydrogel compound fabric group);
Fig. 3 is hydrogel compound fabric tablets in vitro curve.
Detailed description of the invention:
Being convenient to for making technical scheme of the present invention understand, below in conjunction with concrete test example, a kind of medical dressing hydrogel of the present invention compound fabric and its preparation method and application being further described.
Embodiment 1: the preparation of medical dressing hydrogel compound fabric:
By 0.4g ammonium ceric nitrate, 25mLN-N-isopropylacrylamide and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, blot the unnecessary ceric ammonium nitrate solution of removing with napkin;
Then by after soaking 30min through the gossypin of initiation reaction in 5mLN-N-isopropylacrylamide and dimethyl formamide mixed solution (25mLN-N-isopropylacrylamide and 1.2g be dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent and prepare gained); Gossypin is laid on dry glass plate, gained substrate polyreaction 48h under a nitrogen atmosphere, and the cleaning of complete reaction afterproduct water is to remove the residue on surface, and the clean sample obtained is 80 DEG C of dryings under vacuo; Be wherein that the residue be embedded in hydrogel needs repeatedly to remove in the cycle three swelling, deswellings with water cleaning to remove the operating principle of residue on surface, all change aqueous solution at every turn; Each cycle soaks 2h under comprising 45 DEG C of aqueous solution soaking 2h and room temperature condition, namely higher or lower than under minimum critical solution temperature (LCST) condition of NIPA;
Be dissolved in distilled water by the poly-N-isopropyl acrylamide-gossypin prepared and a small amount of calcium alginate, form the hydrosol on top layer, low pressure Rotary Evaporators removes solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate provides ion pair for hydrogel is cross-linked to form grid aperture, can promote this effect on a small quantity, not have quantitative limitation.
Embodiment 2: the preparation of medical dressing hydrogel compound fabric:
By 0.4g ammonium ceric nitrate, 25mLN-N-isopropylacrylamide and 1.6g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, blot the unnecessary ceric ammonium nitrate solution of removing with napkin;
Then by after soaking 30min through the gossypin of initiation reaction in 5mLN-N-isopropylacrylamide and dimethyl formamide mixed solution (25mLN-N-isopropylacrylamide and 1.2g be dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent and prepare gained); Gossypin is laid on dry glass plate; Gained substrate polyreaction 48h under a nitrogen atmosphere, the cleaning of complete reaction afterproduct water is to remove the residue on surface, and the clean sample obtained is 80 DEG C of dryings under vacuo; Be wherein that the residue be embedded in hydrogel needs repeatedly to remove in the cycle three swelling, deswellings with water cleaning to remove the operating principle of residue on surface, all change aqueous solution at every turn; Each cycle soaks 2h under comprising 45 DEG C of aqueous solution soaking 2h and room temperature condition, namely higher or lower than under minimum critical solution temperature (LCST) condition of NIPA;
Be dissolved in suitable water by the poly-N-isopropyl acrylamide-gossypin prepared and a small amount of calcium alginate, form the hydrosol on top layer, low pressure Rotary Evaporators removes solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate provides ion pair for hydrogel is cross-linked to form grid aperture, can promote this effect on a small quantity, not have quantitative limitation.
Embodiment 3: the preparation of medical dressing hydrogel compound fabric:
By 0.2g Ammonium persulfate., 25mLN-N-isopropylacrylamide and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, blot the unnecessary ceric ammonium nitrate solution of removing with napkin;
Then by after soaking 30min through the gossypin of initiation reaction in 5mLN-N-isopropylacrylamide and dimethyl formamide mixed solution (25mLN-N-isopropylacrylamide and 1.2g be dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent and prepare gained); Gossypin is laid on dry glass plate, gained substrate polyreaction 48h under a nitrogen atmosphere, and the cleaning of complete reaction afterproduct water is to remove the residue on surface, and the clean sample obtained is 80 DEG C of dryings under vacuo; Be wherein that the residue be embedded in hydrogel needs repeatedly to remove in the cycle three swelling, deswellings with water cleaning to remove the operating principle of residue on surface, all change aqueous solution at every turn.Each cycle soaks 2h under comprising 45 DEG C of aqueous solution soaking 2h and room temperature condition, namely higher or lower than under minimum critical solution temperature (LCST) condition of NIPA;
Be dissolved in suitable water by the poly-N-isopropyl acrylamide-gossypin prepared and a small amount of sodium alginate, form the hydrosol on top layer, low pressure Rotary Evaporators removes solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate provides ion pair for hydrogel is cross-linked to form grid aperture, can promote this effect on a small quantity, not have quantitative limitation.
Embodiment 4: the preparation of medical dressing hydrogel compound fabric:
By 0.2g Ammonium persulfate., 25mLN-N-isopropylacrylamide and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, blot the unnecessary ceric ammonium nitrate solution of removing with napkin;
Then by after soaking 30min through the gossypin of initiation reaction in 5mLN-N-isopropylacrylamide and dimethyl formamide mixed solution (25mLN-N-isopropylacrylamide and 1.2g be dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent and prepare gained); Gossypin is laid on dry glass plate, gained substrate polyreaction 48h under a nitrogen atmosphere, and the cleaning of complete reaction afterproduct water is to remove the residue on surface, and the clean sample obtained is 80 DEG C of dryings under vacuo; Wherein with water cleaning with remove the residue on surface operating principle be embedded in residue in hydrogel to need repeatedly to remove in the cycle three swelling, deswellings, all change aqueous solution at every turn.Each cycle soaks 2h under comprising 45 DEG C of aqueous solution soaking 2h and room temperature condition, namely higher or lower than under minimum critical solution temperature (LCST) condition of NIPA;
Be dissolved in suitable water by the poly-N-isopropyl acrylamide-gossypin prepared and a small amount of calcium alginate, form the hydrosol on top layer, low pressure Rotary Evaporators removes solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate provides ion pair for hydrogel is cross-linked to form grid aperture, can promote this effect on a small quantity, not have quantitative limitation.
Embodiment 5: the hydrogel compound fabric containing Butyl Flufenamate Ointment:
The hydrogel compound fabric of gained prepared by embodiment 1-4 with swelling saturated under 25 DEG C of conditions containing Butyl Flufenamate Ointment solution, dry, sealing is preserved, low temperature storage.
Embodiment 6: the hydrogel compound fabric of hydrochloric berberine:
Hydrogel gained being prepared by embodiment 1-4 is swelling saturated under 25 DEG C of conditions with hydrochloric berberine nano-emulsion solution, dry, and sealing is preserved, low temperature storage.
Embodiment 7: the hydrogel compound fabric containing matrine:
The hydrogel of gained prepared by embodiment 1-4 with swelling saturated under 25 DEG C of conditions containing matrine solution, dry, sealing is preserved, low temperature storage.
Test below by way of to the hydrogel compound fabric of preparation, further the performance of checking medical dressing hydrogel compound fabric of the present invention:
1, Equilibrium swelling ratio:
Test condition: 37 DEG C, swellbility=(W
t-W
o)/W
o
W
t-hydrogel compound fabric reaches weight during swelling equilibrium, W
othe weight of-dried hydrogel compound fabric
According to Pan Chunyue, Yu Dian, grand clear moral, waits the swelling and Release Performance [J] of .NIPAAm system copolymerization thermosensitive hydrogel. Central South University's journal (natural science edition), 2007,38(5): the method for testing in 906-911., according to above-mentioned test condition, embodiment 1 prepares the Swelling Dynamics performance of the medical dressing hydrogel compound fabric of gained as shown in Figure 1, and hydrogel compound fabric reached solvent swelling state rapidly in 5 minutes, and maintaining long swelling equilibrium, absorb subsemimodule is good.
Embodiment 2 ~ 4 after testing after the coming to the same thing of result and embodiment 1.
The pharmacodynamics test of the pastille hydrogel compound fabric prepared below by way of the present invention and release behaviour in vitro set forth the beneficial effect that product water gel compound fabric of the present invention has further:
Test example one: in-vitro antibacterial anti-inflammatory activity is tested:
30 SD rats are divided into 6 groups at random, are respectively model group, normal group, positive controls, common gauze and combination therapies group, not pastille hydrogel compound fabric group and hydrochloric berberine hydrogel compound fabric (prepared by embodiment 6).Under general anesthesia, rat back loses hair or feathers, and normal saline cleans up epilating area, marks one and is about 2cm, the otch of full thickness with scalpel, and normal group only does depilation process; Except normal group, with the bacterium liquid of staphylococcus aureus, there is wound infection phenomenon in all the other 5 groups of cutting part inoculations after 24h.Except model group, all the other Four composition do not give
calcium alginate fibre (positive controls); Common gauze and berberine powder (drug combination group); Not pastille hydrogel compound fabric and pastille hydrogel compound fabric, all with adhesive tape fixing protection wound after administration.Change a medicine every 3 days, after one week, put to death animal.Take out wound skin histology, after 10% formaldehyde fixes 24h, dehydration, paraffin embedding, is cut into the section of about 4 μm, and HE dyes, the situations such as electric Microscopic observation skin histology inflammatory cell infiltration and angiogenesis.
Result is as Fig. 2, known pastille hydrogel compound fabric effectively can treat the reaction of body surface nonspecific inflammation, and the obvious infection caused by pathogenic microorganism suppressing to introduce in process of changing dressings, wherein a is model group, b is normal group, and c is positive controls, and d is common gauze and combination therapies group, e is not pastille hydrogel compound fabric group, and f is pastille hydrogel compound fabric group)
Test example two: hydrogel compound fabric tablets in vitro is tested:
Employing dynamic dialysis method measures (Zou Dongna, Zhang Dianrui, Zhang Xueshun, etc. the preparation of matrine albumin microsphere and character [J]. Chinese Journal of Pharmaceuticals, 2006,37 (12): 824; Chen Yongshun, Chen Li. the preparation of silibinin gelatine microsphere and tablets in vitro [J]. Chinese experimental pharmacology of Chinese medical formulae magazine, 2011,17 (24): 23.) vitro release of berberine hydrogel compound fabric.Get 3 parts by parallel for berberine hydrogel compound fabric, be respectively charged in the bag filter handled well, two ends are fastened, and are fixed on the stirring paddle of digestion instrument.With 250mL normal saline for release medium, be 32 ± 0.5 DEG C in temperature, rotating speed is 100rmin
-1condition under carry out tablets in vitro experiment.Take out 1mL release medium respectively at 0,1,2,4,8,12,24,48,72h, add the fresh dissolution medium of equality of temperature same volume simultaneously.
As shown in Figure 3, hydrogel compound fabric is cumulative release 46.52% in 24h, and result shows for result, and hydrogel compound fabric carrier has certain slow releasing function.
The above, be only preferred embodiment of the present invention, not any formal and substantial restriction is done to the present invention, all those skilled in the art, do not departing within the scope of technical solution of the present invention, when utilizing disclosed above technology contents, and a little change made, modify with differentiation equivalent variations, be Equivalent embodiments of the present invention; Meanwhile, all according to substantial technological of the present invention to the change of any equivalent variations that above embodiment is done, modify and differentiation, all still belong in the scope of technical scheme of the present invention.
Claims (5)
1. a preparation method for medical dressing hydrogel compound fabric, comprises the steps:
(1), by 25mLN-N-isopropylacrylamide, 1.2g dimethyl formamide and initiator are dissolved in 0.1M salpeter solution, with nitrogen gas foaming; Described initiator is selected from the one in ammonium ceric nitrate and Ammonium persulfate.; Initiator is dissolved in 0.1M salpeter solution and obtains initiator solution; 25mLN-N-isopropylacrylamide and 1.2g are dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent, obtain NIPA and dimethyl formamide mixed solution;
(2) the initiator solution initiation reaction 15min that 200mg gossypin 10mL concentration is 10 ~ 20mM, is taken;
(3), in step (2) after the gossypin of initiation reaction soaks 30min in the NIPA and dimethyl formamide mixed solution of 5mL step (1), to be laid on dry glass plate polyreaction 48h under a nitrogen atmosphere, to obtain poly-N-isopropyl acrylamide-gossypin;
(4) poly-N-isopropyl acrylamide-gossypin, prepared and alginate are dissolved in distilled water, form the hydrosol on top layer, and low pressure Rotary Evaporators removes solvent, obtains medical dressing hydrogel compound fabric.
2. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, is characterized in that, in step (1), the volume ratio of NIPA is 25% ~ 50%, and the mass volume ratio of initiator is 2% ~ 5%.
3. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, it is characterized in that, the concrete steps of step (1) are: by 0.4g ammonium ceric nitrate, 25mLN-N-isopropylacrylamide and 1.2g dimethyl formamide are dissolved in 0.1M salpeter solution, use nitrogen gas foaming.
4. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, it is characterized in that, the concrete steps of step (1) are: by 0.2g Ammonium persulfate., 25mLN-N-isopropylacrylamide and 1.2g dimethyl formamide are dissolved in 0.1M salpeter solution, use nitrogen gas foaming.
5. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, it is characterized in that, the alginate in step (4) is sodium alginate or calcium alginate.
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| PCT/CN2015/070378 WO2015103988A1 (en) | 2014-01-10 | 2015-01-08 | Medical dressing hydrogel composite fabric, and preparation method therefor and uses thereof |
| CN201580000491.2A CN105228658B (en) | 2014-01-10 | 2015-01-08 | A kind of medical dressing hydrogel compound fabric and its preparation method and application |
| HK16105102.6A HK1218631A1 (en) | 2014-01-10 | 2016-05-04 | Medical dressing hydrogel composite fabric, and preparation method therefor and uses thereof |
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| CN104258469B (en) * | 2014-08-29 | 2016-03-02 | 赵兰 | A kind of preparation method of degerming antibacterial chitosan-cellulose adherence preventing material |
| CN109568643B (en) * | 2018-10-21 | 2021-08-31 | 浙江理工大学 | Preparation method and application of berberine-containing antibacterial hemostatic microspheres |
| CN109331218B (en) * | 2018-12-05 | 2021-08-10 | 浙江理工大学 | Hemostatic microsphere containing antibacterial component berberine and preparation method and application thereof |
| CN110105590B (en) * | 2019-04-30 | 2021-09-24 | 南京林业大学 | Preparation method and application of flexible strain sensor based on carboxymethyl cellulose/lithium chloride-polyacrylamide hydrogel |
| CN112007201B (en) * | 2020-08-12 | 2021-10-19 | 山东百多安医疗器械股份有限公司 | Adhesive antibacterial hemostatic sponge and preparation method thereof |
| CN112869948B (en) * | 2021-01-12 | 2022-10-04 | 香港理工大学 | Intelligent moisture-responsive compression fabric, preparation method thereof and intelligent moisture-responsive compression bandage |
| CN113730642B (en) * | 2021-08-20 | 2022-05-31 | 东华大学 | Gradient elastic deformation differential drug release composite dressing and preparation method thereof |
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| CN103147290A (en) * | 2013-03-07 | 2013-06-12 | 中国科学院上海应用物理研究所 | Functional nano textile and preparation method thereof |
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| Publication number | Publication date |
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| CN103736140A (en) | 2014-04-23 |
| CN105228658A (en) | 2016-01-06 |
| WO2015103988A1 (en) | 2015-07-16 |
| CN105228658B (en) | 2018-04-20 |
| HK1218631A1 (en) | 2017-03-03 |
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