CN103736140A - Medical dressing hydrogel composite fabric as well as preparation method and application thereof - Google Patents
Medical dressing hydrogel composite fabric as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN103736140A CN103736140A CN201410013667.5A CN201410013667A CN103736140A CN 103736140 A CN103736140 A CN 103736140A CN 201410013667 A CN201410013667 A CN 201410013667A CN 103736140 A CN103736140 A CN 103736140A
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- Prior art keywords
- medical dressing
- compound fabric
- preparation
- hydrogel compound
- dressing hydrogel
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
- C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
- C08F251/02—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof on to cellulose or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/04—Alginic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/02—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to polysaccharides
Abstract
The invention relates to a medical dressing hydrogel composite fabric as well as a preparation method and an application thereof and belongs to the technical field of a traditional Chinese medicine preparation and a preparation method thereof. The preparation method comprises the following steps: dissolving N-isopropylacrylamide and an initiator by using a solvent and foaming by using nitrogen; carrying out initiation reaction on cotton cellulose in the initiator; soaking the cotton cellulose after the initiation reaction in the mixed solution of N-isopropylacrylamide and dimethylfomamide and then carrying out polymerization reaction in the presence of nitrogen to acquire poly(N-isopropyl acrylamide-cotton cellulose); dissolving poly(N-isopropyl acrylamide-cotton cellulose) together with alginate in distilled water to form hydrosol on the surface, and removing the solvent under low pressure by a rotary evaporator to acquire the medical dressing hydrogel composite fabric. The medical dressing hydrogel composite fabric has the advantages of having high mechanical strength and anti-microbial, anti-infective and hematostatic functions, intelligently controlling humidity to maintain hydrated skin, preventing adhesion of the fabric and cambiums and effectively promoting epithelization and wound healing of tissue cells.
Description
Technical field
The invention belongs to Chinese medicine preparation and preparation method thereof technical field, be specifically related to a kind of medical dressing hydrogel compound fabric and its preparation method and application, be mainly used in hemostasis and the tissue repair of various acute and chronic wounds.
Background technology
Local wound and hemorrhage, the infection causing, ulcer are a kind of commonly seen injuries, and malpractice tends to cause wound inflammation, suppuration, even infects ulcer.Traditional method generally adopts sterile gauze and topical antibiotic medicine to process.Traditional gauze class dressing cannot keep wound surface moistening, hinders histiocyte epithelization, and wound healing postpones; Dressing fiber easily comes off, and causes foreign body reaction, impact healing; Wound surface granulation tissue is easily grown in the mesh of dressing and is sticked together, and usually destroys newborn epithelium and granulation tissue while changing dressings, and causes bleeding, and this is not only unfavorable for the healing of wound, and makes Principle of Pain unbearably; Water absorption is not strong, and haemostatic effect is not good enough, and pathogen easily sees through gauze infected wound; The workload of changing dressings is large.
Hydrogel is by the cross-linked macromole with three-D space structure forming between molecule by hydrophilic macromolecular compounds.Because the high molecular peculiar hydrophilic-structure of hydrogel, a large amount of moisture can be adsorbed and be retained in hydrogel structure, therefore has good water-absorbing-retaining performance.Since British scientist George Winter in 1962 finds that moist environment is conducive to wound healing, various new-type dressing of half a century has in the past obtained development widely, as aerogel dressing, bearing hydrocolloid dressing, minerals dressing and nanotechnology dressing etc.Compared with other dressing, aerogel dressing has unique advantage, and aerogel dressing can prevent excessively scattering and disappearing of moisture and body fluid and play the effect of hemostasis; To water with oxygen has good permeability and do not allow antibacterial to pass through, can resist the invasion of antibacterial, and the growth of anti-bacteria, there is function antibacterial, antiinflammatory; Can close well with wound surface note, but can with free of replacement dressing belt, not carry out secondary damage with wound surface adhesion; Moisture-inhibiting, breathe freely and make wound surface in moistening but there is no the environment of hydrops, good biocompatibility, has the function that can promote wound healing, is more and more subject to the attention of various countries.As the people such as Yang Qing (Yang Qing, Wu Ying, Zhang Yueting. a kind of medical chitosan transparent hydrogel wound dressing and preparation thereof and application: 20091004724.5[P] .2009-3-13) a kind of medical chitosan transparent hydrogel wound dressing and preparation and application disclosed.They,, by preparation chitosan serosity, polyvinyl pyrrolidone PVP solution and acid polyethylene sodium solution, mix and add initiator and cross-linking agent, pour mould into, at 40-75 ℃ of temperature, reaction obtains primary product, antiseptic is added on surface, dries, and cutting is packed and be get final product.But there is the defect of bad mechanical strength in it, during application, often need to fix, bring inconvenience.
Summary of the invention
Hydrogel can be divided into chemical gel and physical gel according to cross-linked mode difference.The polymer molecular chain of chemical gel links by covalent bond, and physical gel is by non-covalent bond combinations such as hydrogen bond, ionization and hydrophobicity effects.The water sorption of hydrogel and the composition of polymer, kind, link density and ambient temperature, acid-base value, ionic strength has substantial connection.The size of the granular size of hydrogel, contained micropore also has impact to the speed of water suction in addition.Common hydrogel has poly hydroxy ethyl acrylate, polyacrylic acid hydroxypropyl acrylate, polypyrrole alkane ketone, polyacrylic acid and polyacrylamide etc.
Temperature sensitive intelligent hydrogel based on NIPA, it is a kind of typical thermal shrinkage type temperature-sensitive hydrogel, the variation of its response environment temperature and occur swelling or shrink, minimum critical solution temperature is 32 ℃ of left and right, approach people's shell temperature, can be used as medical dressing and be widely used in the tissue repair of body surface wound.Chitosan has bright significant bacteriostasis, and the skin bacterium existing for general human epidermal all has obvious inhibitory action as staphylococcus aureus, bacillus pyocyaneus and streptococcus pyogenes etc.Meanwhile, chitosan can promote epithelial regeneration, the speed of accelerating wound, the quality of raising wound healing.Chitosan can be degraded into even monosaccharide of oligosaccharide, oligosaccharide, is conducive to accelerate cell proliferation and strengthens tissue remodeling.And, the each tool advantage of chitosan of different molecular weight size, it is good that the chitosan of macromolecule has into film-strength, and the chitosan of micromolecule amount has that biological activity is high, the feature of good water-retaining property, uses the two can the good medical dressing of processability.
The object of the invention is to disclose a kind of medical dressing hydrogel compound fabric; Compared with other dressing, hydrogel compound fabric has unique advantage as medical dressing, and aerogel dressing can prevent excessively scattering and disappearing of moisture and body fluid and play the effect of hemostasis; To water with oxygen has good permeability and do not allow antibacterial to pass through, can resist the invasion of antibacterial, and the growth of anti-bacteria, there is function antibacterial, antiinflammatory; Can close well with wound surface note, but can with free of replacement dressing belt, not carry out secondary damage with wound surface adhesion; Moisture-inhibiting, breathe freely and make wound surface in moistening but there is no the environment of hydrops, good biocompatibility, has the function that can promote wound healing.
Second object of the present invention has been to disclose the preparation method of above-mentioned medical dressing hydrogel compound fabric.
The 3rd object of the present invention has been to disclose above-mentioned medical dressing hydrogel compound fabric in the application of preparing in anti-inflammation and haemostatic medicament; Above-mentioned medical dressing hydrogel compound fabric is as dressing, and the common drug of some anti-inflammations and hemostasis, if flufenamic acid butyl ester, matrine or berberine hydrochloride etc. are as active component.
The object of the invention is to be achieved through the following technical solutions:
A preparation method for medical dressing hydrogel compound fabric, comprises the steps:
(1), by NIPA and initiator dissolution with solvents, with nitrogen gas foaming; Described initiator is selected from the one in ammonium ceric nitrate and Ammonium persulfate.;
(2), take the initiator solution initiation reaction 15min that 200mg gossypin 10mL concentration is 10～20mM;
(3), 25mL NIPA and 1.2g are dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent, obtain NIPA and dimethyl formamide mixed solution;
(4), in step (2), through the gossypin of initiation reaction, in the solution of 5mL step (3), soak after 30min, be laid on dry glass plate polyreaction 48h under condition of nitrogen gas, obtain poly-N-isopropyl acrylamide-gossypin;
(5) poly-N-isopropyl acrylamide-gossypin of, having prepared and alginate are dissolved in distilled water, form the hydrosol on top layer, and low pressure Rotary Evaporators is removed solvent, obtains medical dressing hydrogel compound fabric.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, in step (1), the volume ratio of NIPA is 25%～50%, the mass volume ratio of initiator is 2%～5%.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, the concrete steps of step (1) are: by 0.4g ammonium ceric nitrate, 25mL NIPA and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, use nitrogen gas foaming.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, the concrete steps of step (1) are: by 0.2g Ammonium persulfate., 25mL NIPA and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, use nitrogen gas foaming.
The preparation method of a kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, the alginate in step (5) is sodium alginate or calcium alginate.
A kind of medical dressing hydrogel compound fabric, wherein, described medical dressing hydrogel compound fabric is to be prepared by the preparation method described in technique scheme.
A kind of medical dressing hydrogel compound fabric described in technique scheme, wherein, in medical dressing hydrogel compound fabric, the content of NIPA is mass percent 6%～30%.
A kind of medical dressing hydrogel compound fabric is in the application of preparing in anti-inflammation and haemostatic medicament, described anti-inflammation and haemostatic medicament are comprised of dressing and active component, wherein, described active component is flufenamic acid butyl ester, matrine or berberine hydrochloride, and described dressing is the medical dressing hydrogel compound fabric described in technique scheme.
A kind of medical dressing hydrogel compound fabric described in technique scheme is in the application of preparing in anti-inflammation and haemostatic medicament, and wherein, the mass percent that active component accounts for medicine is 2%～5%.
The present invention has following beneficial effect:
1, medical dressing hydrogel compound fabric of the present invention adopts natural Biodegradable macromolecular material, has certain antimicrobial and anti-inflammation efficacy, and good biocompatibility greatly reduces the risk of immunological rejection.
2, medical dressing hydrogel compound fabric of the present invention has added medicine, as flufenamic acid butyl ester, matrine and berberine hydrochloride etc., make hydrogel compound fabric there is the function of good antibacterial, antiinflammatory, hemostasis and promotion wound healing, the infection of avoiding external environment and changing dressings in process; Meanwhile, the water-absorbing-retaining performance of hydrogel compound fabric is good, for wound, has created a moistening environment, is conducive to wound healing and changes dressings.
3, medical dressing hydrogel compound fabric of the present invention is Thermo-sensitive " intelligence " material, be subject to shell temperature variation and swelling or shrink, can make sustained release, drug effect cycle stretch-out, dwindles the frequency of changing dressings, workload reduces.
4, the preparation process of medical dressing hydrogel compound fabric of the present invention is simple, and agents useful for same and raw material be commercially available obtaining all, can produce continuously.
Accompanying drawing explanation:
Fig. 1 is hydrogel compound fabric at the Swelling Dynamics curve of 37 ℃;
Fig. 2 is rat skin pathological section (a is model group, and b is normal group, the positive matched group of c, d is common gauze and medication combined medication group, e is pastille hydrogel compound fabric group not, f is pastille hydrogel compound fabric group);
Fig. 3 is hydrogel compound fabric tablets in vitro curve.
The specific embodiment:
For making technical scheme of the present invention be convenient to understand, below in conjunction with concrete test example, a kind of medical dressing hydrogel of the present invention compound fabric and its preparation method and application is further described.
Embodiment 1: the preparation of medical dressing hydrogel compound fabric:
By 0.4g ammonium ceric nitrate, 25mL NIPA and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, with napkin, blot and remove unnecessary ceric ammonium nitrate solution;
Then by through the gossypin of initiation reaction in soaking in 5mL NIPA and dimethyl formamide mixed solution (25mL NIPA and 1.2g are dissolved in 0.1M nitric acid and prepare gained as the dimethyl formamide of cross-linking agent) after 30min; Gossypin is laid on dry glass plate, and gained substrate is polyreaction 48h under condition of nitrogen gas, and complete reaction afterproduct water cleans to remove surperficial residue, the clean sample obtaining under vacuum 80 ℃ dry; Wherein to clean to remove the operating principle of surperficial residue be to be embedded in residue in hydrogel need in the cycle, repeatedly remove three swelling, deswellings to water, all changes aqueous solution at every turn; Each cycle comprises under 45 ℃ of aqueous solution soaking 2h and room temperature condition soaks 2h, under minimum critical solution temperature (LCST) condition higher or lower than NIPA;
Poly-N-isopropyl acrylamide-gossypin of having prepared and a small amount of calcium alginate are dissolved in distilled water, form the hydrosol on top layer, low pressure Rotary Evaporators is removed solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate is to provide ion pair for hydrogel is cross-linked to form grid aperture, and can promote on a small quantity this effect does not have quantitative limitation.
Embodiment 2: the preparation of medical dressing hydrogel compound fabric:
By 0.4g ammonium ceric nitrate, 25mL NIPA and 1.6g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, with napkin, blot and remove unnecessary ceric ammonium nitrate solution;
Then by through the gossypin of initiation reaction in soaking in 5mL NIPA and dimethyl formamide mixed solution (25mL NIPA and 1.2g are dissolved in 0.1M nitric acid and prepare gained as the dimethyl formamide of cross-linking agent) after 30min; Gossypin is laid on dry glass plate; Gained substrate is polyreaction 48h under condition of nitrogen gas, and complete reaction afterproduct water cleans to remove surperficial residue, the clean sample obtaining under vacuum 80 ℃ dry; Wherein to clean to remove the operating principle of surperficial residue be to be embedded in residue in hydrogel need in the cycle, repeatedly remove three swelling, deswellings to water, all changes aqueous solution at every turn; Each cycle comprises under 45 ℃ of aqueous solution soaking 2h and room temperature condition soaks 2h, under minimum critical solution temperature (LCST) condition higher or lower than NIPA;
Poly-N-isopropyl acrylamide-gossypin of having prepared and a small amount of calcium alginate are dissolved in suitable water, form the hydrosol on top layer, low pressure Rotary Evaporators is removed solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate is to provide ion pair for hydrogel is cross-linked to form grid aperture, and can promote on a small quantity this effect does not have quantitative limitation.
Embodiment 3: the preparation of medical dressing hydrogel compound fabric:
By 0.2g Ammonium persulfate., 25mL NIPA and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, with napkin, blot and remove unnecessary ceric ammonium nitrate solution;
Then by through the gossypin of initiation reaction in soaking in 5mL NIPA and dimethyl formamide mixed solution (25mL NIPA and 1.2g are dissolved in 0.1M nitric acid and prepare gained as the dimethyl formamide of cross-linking agent) after 30min; Gossypin is laid on dry glass plate, and gained substrate is polyreaction 48h under condition of nitrogen gas, and complete reaction afterproduct water cleans to remove surperficial residue, the clean sample obtaining under vacuum 80 ℃ dry; Wherein to clean to remove the operating principle of surperficial residue be to be embedded in residue in hydrogel need in the cycle, repeatedly remove three swelling, deswellings to water, all changes aqueous solution at every turn.Each cycle comprises under 45 ℃ of aqueous solution soaking 2h and room temperature condition soaks 2h, under minimum critical solution temperature (LCST) condition higher or lower than NIPA;
Poly-N-isopropyl acrylamide-gossypin of having prepared and a small amount of sodium alginate are dissolved in suitable water, form the hydrosol on top layer, low pressure Rotary Evaporators is removed solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate is to provide ion pair for hydrogel is cross-linked to form grid aperture, and can promote on a small quantity this effect does not have quantitative limitation.
Embodiment 4: the preparation of medical dressing hydrogel compound fabric:
By 0.2g Ammonium persulfate., 25mL NIPA and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, and nitrogen gas foaming;
Take the ceric ammonium nitrate solution initiation reaction 15min that 200mg gossypin 10mL concentration is 20mM, with napkin, blot and remove unnecessary ceric ammonium nitrate solution;
Then by through the gossypin of initiation reaction in soaking in 5mL NIPA and dimethyl formamide mixed solution (25mL NIPA and 1.2g are dissolved in 0.1M nitric acid and prepare gained as the dimethyl formamide of cross-linking agent) after 30min; Gossypin is laid on dry glass plate, and gained substrate is polyreaction 48h under condition of nitrogen gas, and complete reaction afterproduct water cleans to remove surperficial residue, the clean sample obtaining under vacuum 80 ℃ dry; Wherein water clean to remove surperficial residue operating principle be to be embedded in residue in hydrogel need in the cycle, repeatedly remove three swelling, deswellings, all change aqueous solution at every turn.Each cycle comprises under 45 ℃ of aqueous solution soaking 2h and room temperature condition soaks 2h, under minimum critical solution temperature (LCST) condition higher or lower than NIPA;
Poly-N-isopropyl acrylamide-gossypin of having prepared and a small amount of calcium alginate are dissolved in suitable water, form the hydrosol on top layer, low pressure Rotary Evaporators is removed solvent, obtains medical dressing hydrogel compound fabric.In this step, the effect of calcium alginate is to provide ion pair for hydrogel is cross-linked to form grid aperture, and can promote on a small quantity this effect does not have quantitative limitation.
Embodiment 5: the hydrogel compound fabric of fluorine-containing that acid butyl ester of sweet smell:
That acid butyl ester solution of the fluorine-containing sweet smell of hydrogel compound fabric of being prepared by embodiment 1-4 to gained is swelling saturated under 25 ℃ of conditions, dry, and sealing is preserved, low temperature storage.
Embodiment 6: the hydrogel compound fabric of hydrochloric berberine:
The hydrogel of being prepared by embodiment 1-4 to gained is swelling saturated under 25 ℃ of conditions with hydrochloric berberine nano-emulsion solution, dry, and sealing is preserved, low temperature storage.
Embodiment 7: the hydrogel compound fabric that contains matrine:
Prepared by embodiment 1-4 to the hydrogel of gained with swelling saturated under 25 ℃ of conditions containing matrine solution, dry, sealing is preserved, low temperature storage.
By the hydrogel compound fabric of preparation is tested, further verify the performance of medical dressing hydrogel compound fabric of the present invention below:
1, equilibrium swelling degree:
Test condition: 37 ℃, swellbility=(W
t-W
o)/W
o
W
tweight when-hydrogel compound fabric reaches swelling equilibrium, W
othe weight of-dried hydrogel compound fabric
According to Pan Chunyue, in allusion quotation, grand clear moral, waiting .NIPAAm is the swelling and Release Performance [J] of copolymerization thermosensitive hydrogel. Central South University's journal (natural science edition), 2007,38(5): the method for testing in 906-911., according to above-mentioned test condition, embodiment 1 prepare gained medical dressing hydrogel compound fabric Swelling Dynamics performance as shown in Figure 1, hydrogel compound fabric reached rapidly solvent swelling state in 5 minutes, and maintaining long swelling equilibrium, water-absorbing-retaining performance is good.
The pharmacodynamics test of the pastille hydrogel compound fabric of preparing by the present invention below and release behaviour in vitro are further set forth the beneficial effect that product water gel compound fabric of the present invention has:
Test example one: in-vitro antibacterial anti-inflammatory activity test:
30 SD rats are divided into 6 groups at random, are respectively model group, normal group, positive controls, common gauze and medication combined medication group, not pastille hydrogel compound fabric group and hydrochloric berberine hydrogel compound fabric (prepared by embodiment 6).Under general anesthesia, rat back depilation, normal saline cleans up depilation region, and with scalpel, mark one and be about 2cm, the otch of holostrome thickness, normal group is only done depilation and is processed; Except normal group, with the bacterium liquid of staphylococcus aureus, there is wound infection phenomenon in all the other 5 groups of cutting part inoculations after 24h.Except model group, all the other four groups give respectively
calcium alginate fibre (positive controls); Common gauze and berberine powder (drug combination group); Not pastille hydrogel compound fabric and pastille hydrogel compound fabric, all fixes protection wound with adhesive tape after administration.Every 3 days, change a medicine, after one week, put to death animal.Taking-up wound skin histology, after the fixing 24h of 10% formaldehyde, dehydration, paraffin embedding, is cut into the section about 4 μ m, HE dyeing, the situations such as electric Microscopic observation skin histology inflammatory cell infiltration and angiogenesis.
Result is as Fig. 2, known pastille hydrogel compound fabric can effectively be treated the reaction of body surface nonspecific inflammation, and the infection due to the pathogenic microorganism that obviously suppresses to introduce in the process of changing dressings, wherein a is model group, b is normal group, the positive matched group of c, and d is common gauze and medication combined medication group, e is pastille hydrogel compound fabric group not, and f is pastille hydrogel compound fabric group)
Test example two: hydrogel compound fabric tablets in vitro experiment:
Employing dynamic dialysis method mensuration (Zou Dongna, Zhang Dianrui, Zhang Xueshun, etc. the preparation of matrine albumin microsphere and character [J]. Chinese Journal of Pharmaceuticals, 2006,37 (12): 824; Chen Yongshun, Chen Li. the preparation of silibinin gelatine microsphere and tablets in vitro [J]. Chinese experimental pharmacology of Chinese medical formulae magazine, 2011,17 (24): the 23.) vitro release of berberine hydrogel compound fabric.By parallel berberine hydrogel compound fabric, get 3 parts, be respectively charged in the bag filter of handling well, two ends are fastened, and are fixed on the stirring paddle of digestion instrument.Take 250mL normal saline as release medium, in temperature, be 32 ± 0.5 ℃, rotating speed is 100rmin
-1condition under carry out tablets in vitro experiment.Respectively at 0,1,2,4,8,12,24,48,72h, take out 1mL release medium, add the fresh release medium of equality of temperature same volume simultaneously.
As shown in Figure 3, hydrogel compound fabric is cumulative release 46.52% in 24h for result, and result shows, hydrogel compound fabric carrier has certain slow releasing function.
The above, it is only preferred embodiment of the present invention, not the present invention is done to any formal and substantial restriction, all those skilled in the art, do not departing within the scope of technical solution of the present invention, when utilizing disclosed above technology contents, and the equivalent variations of a little change of making, modification and differentiation is equivalent embodiment of the present invention; Meanwhile, the change of any equivalent variations that all foundations essence technology of the present invention is done above embodiment, modification and differentiation, all still belong in the scope of technical scheme of the present invention.
Claims (9)
1. a preparation method for medical dressing hydrogel compound fabric, comprises the steps:
(1), by NIPA and initiator dissolution with solvents, with nitrogen gas foaming; Described initiator is selected from the one in ammonium ceric nitrate and Ammonium persulfate.;
(2), take the initiator solution initiation reaction 15min that 200mg gossypin 10mL concentration is 10～20mM;
(3), 25mL NIPA and 1.2g are dissolved in 0.1M nitric acid as the dimethyl formamide of cross-linking agent, obtain NIPA and dimethyl formamide mixed solution;
(4), in step (2), through the gossypin of initiation reaction, in the solution of 5mL step (3), soak after 30min, be laid on dry glass plate polyreaction 48h under condition of nitrogen gas, obtain poly-N-isopropyl acrylamide-gossypin;
(5) poly-N-isopropyl acrylamide-gossypin of, having prepared and alginate are dissolved in distilled water, form the hydrosol on top layer, and low pressure Rotary Evaporators is removed solvent, obtains medical dressing hydrogel compound fabric.
2. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, is characterized in that, in step (1), the volume ratio of NIPA is 25%～50%, and the mass volume ratio of initiator is 2%～5%.
3. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, it is characterized in that, the concrete steps of step (1) are: by 0.4g ammonium ceric nitrate, 25mL NIPA and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, use nitrogen gas foaming.
4. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, it is characterized in that, the concrete steps of step (1) are: by 0.2g Ammonium persulfate., 25mL NIPA and 1.2g dimethyl formamide are dissolved in 0.1mol salpeter solution, use nitrogen gas foaming.
5. the preparation method of a kind of medical dressing hydrogel compound fabric according to claim 1, is characterized in that, the alginate in step (5) is sodium alginate or calcium alginate.
6. a medical dressing hydrogel compound fabric, is characterized in that: described medical dressing hydrogel compound fabric is to be prepared by the preparation method described in claim 1～5.
7. a kind of medical dressing hydrogel compound fabric according to claim 6, is characterized in that: in medical dressing hydrogel compound fabric, the content of NIPA is mass percent 6%～30%.
8. a medical dressing hydrogel compound fabric is in the application of preparing in anti-inflammation and haemostatic medicament, described anti-inflammation and haemostatic medicament are comprised of dressing and active component, it is characterized in that: described active component is flufenamic acid butyl ester, matrine or berberine hydrochloride, described dressing is the medical dressing hydrogel compound fabric described in claim 6 or 7.
9. a kind of medical dressing hydrogel compound fabric according to claim 8, in the application of preparing in anti-inflammation and haemostatic medicament, is characterized in that: the mass percent that active component accounts for medicine is 2%～5%.
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| CN201580000491.2A CN105228658B (en) | 2014-01-10 | 2015-01-08 | A kind of medical dressing hydrogel compound fabric and its preparation method and application |
| PCT/CN2015/070378 WO2015103988A1 (en) | 2014-01-10 | 2015-01-08 | Medical dressing hydrogel composite fabric, and preparation method therefor and uses thereof |
| HK16105102.6A HK1218631A1 (en) | 2014-01-10 | 2016-05-04 | Medical dressing hydrogel composite fabric, and preparation method therefor and uses thereof |
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| CN104258469A (en) * | 2014-08-29 | 2015-01-07 | 赵兰 | Preparation method of chitosan-cellulose anti-adhesion material for removing and inhibiting bacteria |
| WO2015103988A1 (en) * | 2014-01-10 | 2015-07-16 | 中国人民解放军第三0二医院 | Medical dressing hydrogel composite fabric, and preparation method therefor and uses thereof |
| CN109331218A (en) * | 2018-12-05 | 2019-02-15 | 浙江理工大学 | A kind of hemostatic microsphere of the jamaicin containing antimicrobial component and its preparation method and application |
| CN109568643A (en) * | 2018-10-21 | 2019-04-05 | 浙江理工大学 | A kind of preparation method and applications of the antibacterial anti hemorrhagic microballoon containing jamaicin |
| CN112869948A (en) * | 2021-01-12 | 2021-06-01 | 香港理工大学 | Intelligent moisture-responsive compression fabric, preparation method thereof and intelligent moisture-responsive compression bandage |
| CN113730642A (en) * | 2021-08-20 | 2021-12-03 | 东华大学 | Gradient elastic deformation differential drug release composite dressing and preparation method thereof |
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| CN110105590B (en) * | 2019-04-30 | 2021-09-24 | 南京林业大学 | Preparation method and application of flexible strain sensor based on carboxymethyl cellulose/lithium chloride-polyacrylamide hydrogel |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015103988A1 (en) | 2015-07-16 |
| CN105228658A (en) | 2016-01-06 |
| HK1218631A1 (en) | 2017-03-03 |
| CN105228658B (en) | 2018-04-20 |
| CN103736140B (en) | 2016-04-27 |
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