CN103705324B - The preparation method of blood vessel coating bracket - Google Patents
The preparation method of blood vessel coating bracket Download PDFInfo
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- CN103705324B CN103705324B CN201310752335.4A CN201310752335A CN103705324B CN 103705324 B CN103705324 B CN 103705324B CN 201310752335 A CN201310752335 A CN 201310752335A CN 103705324 B CN103705324 B CN 103705324B
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Abstract
The preparation method of blood vessel coating bracket provided by the invention includes: run through by mandrel in the cavity of intravascular stent body coaxially, and the shore hardness D of described mandrel top layer or entirety is less than 60 or more than 86；Change the outer surface of described mandrel and the gap of described intravascular stent inwall, until both seamless contact or part contact；Coating solution is sprayed at described intravascular stent body；With remove described mandrel.The method can prepare a kind of outer wall and sidewall contains coating, and inwall has the coating bracket of discontinuous coating without coating or inwall, effectively controls blood vessel coating bracket inside coating amount.
Description
Technical field
The invention belongs to implanted medical device field, be specifically related to preparation method and the blood vessel coating bracket of a kind of blood vessel coating bracket.
Background technology
Intravascular stent is a kind of blood vessel implant, has expansiveness, after implantation, it is possible to play the effect radially supported so that myocardial revascularization.The rack body structure of existing intravascular stent is as it is shown in figure 1, its cylindrical tube structure with inner chamber 02 being made up of cradling piece 01, and cradling piece 01 is in fenestral fabric.Cradling piece 01 cross section includes cradling piece outer wall 03, sidewall 04, inwall 05, as shown in Figure 2.
The preparation of current intravascular stent is prepared from mainly by cutting and establishment two ways, by the support after cutting or weaving, it is required for through polishing repeatedly or polishing, cleaning process, so that cradling piece 01 surface relative smooth, thus reducing the support damage to blood vessel wall, it is also beneficial to the spraying of coating, but after above-mentioned technical process, bracket edge would generally be made to have certain chamfering, or cradling piece wall is fluted, so that cradling piece cross section presents irregular shape, if any certain chamfering or irregular square, trapezoidal, circular, oval, polygon.After stenter to implant blood vessel, owing to stent implantation procedure can make vascular damaged that vessel wall inflammation can be caused to react, thus causing smooth muscle cell proliferation, still suffering from a certain proportion of vascular restenosis and occurring, thus weakening the support blood vessels that support plays to make the effect that blood fortune is unimpeded.
For the generation overcoming vascular restenosis to occur, have developed drug stent.Current drug stent is the polymer coating containing active constituents of medicine at the cradling piece 01 overlying lid layer of rack body as shown in Figure 1, is suppressed the generation of vascular restenosis by the ingredient of activity.But when specifically applying, only support outer wall contacts with blood vessel wall with sidewall, the medicine that support outer wall and sidewall discharge can play the effect suppressing the pre-preventing restenosis of blood vessel of blood vessel wall neointimal hyperplasia by intravasation wall, the medicine of rack inner wall then cannot play the effect suppressing neointimal hyperplasia, being released into blood on the contrary, other organs, to whole body, are played side effect by circulation, additionally also can suppress support endothelialization, increase thrombotic risk.Therefore, it is necessary to provide the preparation method of a kind of coating bracket to reduce or avoid rack inner wall seal coat.
Summary of the invention
The blood vessel coating bracket preparation method that the present invention one technical scheme provides comprises the steps: to run through the shore hardness D of top layer or the entirety mandrel less than 60 coaxially in the cavity of intravascular stent body；Change the outer surface of described mandrel and the gap of described intravascular stent inwall, until both seamless contacts；Coating solution is sprayed at described intravascular stent body；With remove described mandrel.
The blood vessel coating bracket preparation method that another technical scheme of the present invention provides comprises the steps: to run through mandrel coaxially in the cavity of intravascular stent body, and the shore hardness D of described mandrel top layer or entirety is more than 86；Change the outer surface of described mandrel and the gap of described intravascular stent inwall, until both part contact；Coating solution is sprayed at described intravascular stent body；With remove described mandrel.
In one embodiment of the invention, elastic deformation can be there is in described top layer, and external diameter is more than the internal diameter of described intravascular stent body, described being run through coaxially by mandrel in described cavity includes with the gap within described intravascular stent with the outer surface of the described mandrel of change: stretch the described mandrel external diameter to described mandrel less than described internal diameter；By described mandrel through described intravascular stent body coaxially；Remove stretching action and recover deformation to described mandrel.
In one embodiment of the invention, described outside diameter of mandrel substantially mates with the internal diameter of described intravascular stent body, the outer surface of the described mandrel of described change and the gap within described intravascular stent include: be placed in by the intravascular stent body being through with described mandrel in reagent and soak, until described mandrel top layer is expanded to described mandrel outer surface and contacts with the interior wall seamless of intravascular stent body or take out from described reagent after part contact.
In one embodiment of the invention, described outside diameter of mandrel is slightly less than the gap of the internal diameter of described intravascular stent body, the outer surface of the described mandrel of described change and described intravascular stent inwall and includes along intravascular stent body described in the radial compression of described intravascular stent body.
In one embodiment of the invention, described coating solution is sprayed at described intravascular stent body outer surface with ultrasonic spraying coating process, and ultrasonic power is 0.5～1.5w.
In one embodiment of the invention, the internal diameter of described blood vessel coating bracket body is not equal to the radius of curvature of described blood vessel coating bracket inner body wall.
It is worth mentioning that, mandrel being run through coaxially before in described cavity, also in the outer wall of described intravascular stent body, inwall and sidewall, coating can be formed by least one wall, namely the preparation method of the blood vessel coating bracket that one embodiment of the invention provides includes spraying aforementioned coatings liquid again at coating surface, the coating that this coating solution is formed is the first coating, and the coating (being namely previously formed in the coating of intravascular stent body surface) that this first coating covers is the second coating.It is to say, this second coating is between this first coating and this intravascular stent body.Preferably, described coating covers whole outer surfaces (i.e. outer wall, inwall and sidewall) of described intravascular stent body.
Certainly, also on described intravascular stent body sprays after described coating solution (namely forming the first coating), coating can be formed again at described first coating surface.It is to say, this this first coating of all or part of covering of the second coating.In certain embodiments, this second coating is also completely covered described inwall.
The present invention one technical scheme also provides for a kind of blood vessel coating bracket, including blood vessel coating bracket body and the first coating being formed at described blood vessel coating bracket body outer wall and sidewall, described blood vessel coating bracket also includes the second coating, described second coating is positioned at described first coating surface, or between described first coating and described intravascular stent body outer surface.
This second coating can partly cover the outer surface of described intravascular stent body.Preferably, described second coating is completely covered described outer surface (i.e. outer wall, sidewall and inwall).
In one embodiment of the invention, described first coating also covers the internal partial wall of blood vessel coating bracket body.
In one embodiment of the invention, the internal diameter of described blood vessel coating bracket body is not equal to the radius of curvature of described blood vessel coating bracket inner body wall, coating on described inwall includes some subregions, is spaced from each other between each subregion, and the coating on this inwall is meaning discontinuous coating.
In an embodiment of the present invention, described first coating and the second coating can be all medication coat；Or described first coating is medication coat, described second coating is non-drug coating；Or described first coating and the second coating can be all non-drug coating.When the first coating and the second coating are all medication coat, the medicine of the non-suppression support endothelialization of medicament selection in described second coating.
In one embodiment of the invention, described first coating and the second coating can be polymer coatings.This polymer coating can accelerate the degraded in human body of the intravascular stent body.Such as, when this intravascular stent body is ferroalloy (including pure iron and alloy thereof) matrix, this polymer can be the polyester containing carboxyl, such as polylactic acid and derivant thereof.Type of polymer in this first coating and the second coating can be different.
In one embodiment of the invention, this first coating is medication coat, and this second coating is polymer coating.
In one embodiment of the invention, the thickness of described coating is 2～50 microns.
Compared with prior art, blood vessel coating bracket preparation method provided by the invention can be passed through to control contacting of mandrel surface and intravascular stent inner body wall two contact surface, and outer wall can be prepared in conjunction with traditional spraying coating process, sidewall has coating, the blood vessel coating bracket that inside coating is controlled, this blood vessel coating bracket inwall is made without coating or to be formed with discontinuous coating, its method can control the coating amount of blood vessel coating bracket inwall flexibly, technique is simple, condition is easy to control, it is thus achieved that blood vessel coating bracket yields high.
By the blood vessel coating bracket of above-mentioned blood vessel coating bracket preparation method acquisition owing to its inwall without coating or is formed with discontinuous coating, effectively reduce the amount of this blood vessel coating bracket inside coating, therefore, when this intravascular stent is coating stent of medicine, after its endovascular, can both play the effect suppressing vascular restenosis, support endothelialization will not be suppressed again or bring other side effect.
Accompanying drawing explanation
Fig. 1 is the rack body structural representation of existing intravascular stent；
Fig. 2 is the cross-sectional view that the rack body shown in Fig. 1 is perpendicular to its axis；
Fig. 3 is the process chart of embodiment of the present invention blood vessel coating bracket preparation method；
Fig. 4 is that in embodiment of the present invention blood vessel coating bracket preparation method, the mandrel that skin-material is the shore hardness D rubber lower than 60 or flexible plastic is arranged in the state diagram in the hollow cavity of intravascular stent body；
Fig. 5 is its schematic diagram contacted with the interior wall seamless of intravascular stent body after the soaking process of the mandrel in Fig. 4 expands；
Fig. 6 is the cradling piece enlarged drawing that contacts seamless with mandrel surface of Fig. 5 medium vessels rack body；
Fig. 7 is through drying the structural representation of the medication coat formed after spraying medication coat liquid on the cradling piece of the intravascular stent body shown in Fig. 5；Wherein, at the inwall of cradling piece without medication coat；
Fig. 8 is in embodiment of the present invention blood vessel coating bracket preparation method, and intravascular stent body 1 its inwall after pressure holds process is higher than the structure for amplifying schematic diagram of the mandrel surface contact surface of 86 with shore hardness D；
Fig. 9 is the Fig. 8 sectional view along A-A；
Figure 10 is the Fig. 8 sectional view along B-B；
Figure 11 is the Fig. 8 sectional view along C-C；
Figure 12 is through drying the structural representation of the medication coat formed after spraying medication coat liquid on the cradling piece of the intravascular stent body shown in Fig. 8；Wherein, it is formed with discontinuous medication coat at the inwall of cradling piece；
Figure 13 is the embodiment of the present invention 3 blood vessel coating bracket preparation method medium vessels rack body 1 structure for amplifying schematic diagram of its cradling piece inwall and mandrel surface contact surface after pressure holds process；
Figure 14 is through drying the structural representation of the medication coat formed after spraying medication coat liquid on the cradling piece of the intravascular stent body shown in Figure 13；Wherein, it is formed with discontinuous medication coat at the inwall of cradling piece；
Figure 15 is that the medication coat liquid in embodiment of the present invention blood vessel coating bracket preparation method adopts ultrasonic spraying coating process schematic diagram；
Figure 16 is the schematic diagram of the blood vessel coating bracket that the embodiment of the present invention 5 provides；
Figure 17 is the schematic diagram of the blood vessel coating bracket that the embodiment of the present invention 6 provides.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and technique effect clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein is only in order to explain the present invention, is not intended to limit the present invention.
It is mostly generally adopt full coat preparing technology to be prepared from due to existing blood vessel drug eluting coating bracket, causes that this blood vessel coating bracket inwall, outer wall and sidewall all have medication coat.Wherein, the medication coat existing for inwall can be released in blood, and other organs, to whole body, are played side effect, additionally also can suppress the endothelialization of blood vessel coating bracket, increase thrombotic risk by circulation.Therefore, if the medication coat of blood vessel coating bracket inwall can be control effectively, the deficiency existing for existing blood vessel coating bracket can effectively be overcome.
Based on above-mentioned reason, embodiments provide the blood vessel coating bracket preparation method that can effectively control inwall medication coat.The method technological process is as it is shown on figure 3, refer to Fig. 4-15 simultaneously, and it comprises the steps:
S01. intravascular stent body 1 and mandrel 2 are obtained: the intravascular stent body 1 obtaining grid hollow tubular and the mandrel 2 matched with the hollow cavity 11 of intravascular stent body 1；
S02. mandrel 2 is arranged in the hollow cavity 11 of intravascular stent body 1 coaxially, and control the contact condition of both contact surfaces: the mandrel 2 obtained in step S01 is worn and is arranged in the hollow cavity 11 of intravascular stent body 1, make mandrel 2 outer surface contact or part contact with the interior wall seamless of intravascular stent body 1；
S03. on intravascular stent body 1, medication coat 3 is prepared: the hollow cavity 11 being sprayed in S02 by medication coat liquid is equipped with on the intravascular stent body 1 of mandrel 2, drying removes mandrel 2 after processing, obtain blood vessel coating bracket, and the inwall of described blood vessel coating bracket without medication coat 3 or is formed with discontinuous medication coat 3.
Specifically, in above-mentioned steps S01, hollow cavity 11 form fit of mandrel 2 and intravascular stent body 1, therefore, it can be arranged in the hollow cavity 11 of intravascular stent body 1, and can pass through to regulate the factor such as its diameter and surface soft or hard, it is achieved the contact condition of the inwall of this mandrel 2 outer surface and intravascular stent body 1, as realized the two seamless contact of contact surface or part contact.Therefore, this mandrel 2 has at least below embodiment:
As the first embodiment of the present invention, this mandrel 2 includes mandrel body 22 and the shore hardness D the being coated on mandrel body 22 surface top layer 21 lower than 60.This top layer 21 can be that rubber or flexible plastic or other flexible materials are made, its structure mandrel 2 as shown in Figure 4 structure.Wherein, this mandrel body 22 can be prepared from by metal, pottery or duroplasts.
As the second embodiment of the present invention, this mandrel 2 is integrally prepared from by shore hardness the D material lower than 60 such as rubber or flexible plastic.
As the third embodiment of the present invention, this mandrel 2 is integrally prepared from by the shore hardness D material higher than 86.In a particular embodiment, this mandrel 2 is prepared from by the shore hardness D metal higher than 86, pottery or plastic or other material.
As the 4th kind of embodiment of the present invention, this mandrel 2 includes mandrel body 22 and the shore hardness D the being coated on mandrel body 22 surface material layer 21 higher than 86, and its structure is such as mandrel 2 structure shown in Fig. 4.In a particular embodiment, this shore hardness D material layer 21 higher than 86 is prepared from by metal, pottery or plastic or other material.Wherein, this mandrel body 22 can be have metal, pottery or duroplasts to be prepared from.
It should be understood that in the first and second embodiments of mandrel 2, the shore hardness D mathematic(al) representation lower than 60 is shore hardness D≤60.The mandrel 2 of this first and second embodiment can realize this mandrel 2 surface and contact with wall seamless in intravascular stent body 1.In the third and fourth embodiment of mandrel 2, the shore hardness D mathematic(al) representation higher than 86 is shore hardness D >=86.The mandrel 2 of this third and fourth embodiment is relatively large due to the hardness on its surface, and due to intravascular stent body 1 inboard wall groove 124 or/and the existence of chamfering 125, as seen in figs. 8-10, there is portion gap between two contacting surface behind mandrel 2 surface and intravascular stent body 1 contact internal walls, namely two contact surfaces are part contact.
It addition, under the instruction of the embodiment of the present invention, adopt the mandrel of other structures also within embodiment of the present invention scope of disclosure.
In this step S01, intravascular stent body 1 is grid hollow tubular.The cylindrical tube structure with inner chamber 11 that this concrete intravascular stent body 1 is made up of cradling piece 12, cradling piece 12 is in fenestral fabric.Cradling piece 12 cross section includes cradling piece outer wall 121, sidewall 122, inwall 123, the structure of cradling piece 12 as shown in Figure 7.Wherein, the outer wall 121 of all cradling pieces 12 constitutes the outer surface of intravascular stent body 1, and the inwall 123 of all cradling pieces 12 constitutes the inner surface of intravascular stent body 1.
For the embodiment of the present invention, there is certain chamfering intravascular stent body 1 at particularly suitable selection cradling piece 12 edge, or particularly suitable selection cradling piece 12 cross section is irregular circle, ellipse, trapezoidal, square etc. intravascular stent body 1, namely it is at least portion support bar 12 inwall and not exclusively overlaps from the circular arc of intravascular stent body 1 internal diameter the intravascular stent body 1 of (namely the radius of curvature of inwall is different with shelf inner diameter).That is to say that blood vessel coating bracket preparation method embodiment of the present invention is particularly suitable for being at least on the intravascular stent body 1 that portion support bar 12 inwall not exclusively overlaps with the circular arc of intravascular stent body 1 internal diameter to form medication coat 3 at such.
In above-mentioned steps S02, mandrel 2 wears and is arranged in different different according to selected mandrel 2 hardness of the mode in the hollow cavity 11 of intravascular stent body 1 and mandrel 2 outer surface and the inwall two contact surface contact condition of intravascular stent body 1.When the concrete material of the outer layer 21 when mandrel 2 or the integral material of mandrel 2 are the shore hardness D rubber lower than 60 or flexible plastic or other materials, namely this mandrel 2 surface contacts with the interior wall seamless of intravascular stent body 1；When the shore hardness D of mandrel 2 is higher than 86, i.e. the inwall two contact surface part contact of this mandrel 2 surface and intravascular stent body 1.Therefore, mandrel 2 wears and is arranged in the mode in the hollow cavity 11 of intravascular stent body 1 and at least has following several embodiment:
The first embodiment, as Figure 4-Figure 6, when mandrel 2 is first embodiment in above-mentioned steps S01, namely mandrel 2 includes mandrel body 22 and is coated on the top layer 21 of mandrel body surface when being the shore hardness D rubber lower than 60 or soft plastic layer or other materials, first mandrel 2 is arranged in the hollow cavity 11 of intravascular stent body 1, now, as shown in Figure 4, there is not seamless contact with intravascular stent body 1 inwall in the outer surface of mandrel 2 to both states.Both are soaked in reagent such as normal heptane, top layer 21 is made to expand, expand until mandrel 2 outer surface takes out after contacting with the interior wall seamless of intravascular stent body 1 until top layer 21, top layer 21 after taking-up contacts as shown in Figure 5,6 with the interior wall seamless of intravascular stent body 1, specifically, cradling piece 12 inwall of intravascular stent body 1 and top layer 21 form close contact interface 23, and both edges 24 do not have gap.
The second embodiment, essentially identical with this first embodiment, be different in that mandrel 2 is placed in together with intravascular stent body 1 in reagent soak time or afterwards, simultaneously to the outer surface of intravascular stent body 1 along this intravascular stent body 1 radial direction apply the pressure effect of holding (also can not apply this radial force), to reduce intravascular stent body 1 internal diameter so that top layer 21 and the inwall of intravascular stent body 1 contact such as Fig. 5, seamless shown in 6.
The third embodiment, when the second embodiment that mandrel is mandrel 2 in above-mentioned steps S01, namely when mandrel 2 integral material is the shore hardness D rubber lower than 60 or flexible plastic, first the rubber of mandrel 2 or flexible plastic are carried out stretcher strain, reduce mandrel 2 diameter, after the hollow cavity 11 of mandrel 2 traverse intravascular stent body 1, remove stretching action, mandrel 2 deformation is restored, its outer surface contacts with the interior wall seamless of intravascular stent body 1, when in this embodiment, mandrel 2 is through hollow cavity 11 and remove after stretching action the contact condition of mandrel 2 outer surface and the inwall of intravascular stent body 1 respectively such as Fig. 4, contact condition shown in 5.Wherein, removing the top layer 21 after stretching action and wall seamless contact condition contact condition as shown in Figure 6 in the cradling piece 12 of intravascular stent body 1, cradling piece 12 and top layer 21 form close contact interface 23, and both edges 24 do not have gap.
4th kind of embodiment, essentially identical with this third embodiment, after being different in that mandrel 2 stretching action is made it deform recovery by removing, also include the outer surface to intravascular stent body 1 and apply to press the step of effect of holding, to reduce intravascular stent body 1 internal diameter so that top layer 21 and the inwall of intravascular stent body 1 contact such as Fig. 5, seamless shown in 6.
5th kind of embodiment, when mandrel 2 is third and fourth embodiment of mandrel 2 in above-mentioned steps S01, namely when the shore hardness D of this mandrel is higher than 86, first mandrel 2 is arranged in the hollow cavity 11 of intravascular stent body 1, again intravascular stent body 1 outer surface is carried out pressure and hold process, hold processing procedure medium vessels rack body 1 stress in pressure and deform so that it is internal diameter reduces, and presents irregularly shaped.After removing the external force that pressure is held, owing to intravascular stent body 1 size rebounds to some extent, again owing to the hardness of mandrel 2 is of a relatively high, although contacting the inwall macroscopically seeing intravascular stent body 1 is seemingly seamless with mandrel 2 outer surface, but examine under a microscope, there is gap in the inwall of intravascular stent body 1 and mandrel 2 outer surface, both are part contact.Specifically, cradling piece 12 inwall of intravascular stent body 1 and the state enlarged drawing of mandrel 2 exterior surface as shown in Figure 8, the groove 124 existed due to cradling piece 12 or chamfering 125 so that its inwall and mandrel 2 exterior surface exist gap.Wherein, along Fig. 8 Section A-A Fig. 9 it can be seen that due to the existence of cradling piece 12 groove 124 so that there is gap in cradling piece 12 inwall at this place and mandrel 2 exterior surface；Section B-B Figure 10 along Fig. 8 is it can be seen that due to the existence of cradling piece 12 chamfering 125 so that cradling piece 12 inwall at this place and mandrel 2 exterior surface exist gap；C-C cross section Figure 11 along Fig. 8 is it can be seen that owing to cradling piece 12 inwall herein is smooth, therefore, cradling piece 12 inwall at this place is seamless contact with mandrel 2 outer surface, is absent from gap.
To sum up, when the shore hardness D of mandrel 2 top layer or entirety is less than 60, by preceding method, the outer surface of mandrel 2 can be made to contact with the interior wall seamless of intravascular stent body 1；When the shore hardness D of mandrel 2 top layer or entirety is more than 86, by preceding method, the outer surface of mandrel 2 can be made to contact with the inner wall section of intravascular stent body 1.
In above-mentioned steps S03, after being sprayed on by medication coat liquid on the intravascular stent body 1 after above-mentioned steps S02 processes, medication coat liquid can stick to outer wall and the sidewall of intravascular stent body 1, that is to say the outer wall and sidewall that can stick to cradling piece 12.Simultaneously, if the inwall of intravascular stent body 1 is seamless contact with the outer surface of mandrel 2, two surfaces of so seamless contact prevent the entrance of this medication coat liquid, treat that medication coat liquid is dried, thus avoid intravascular stent body 1 inwall formed medication coat 3, as it is shown in fig. 7, and only form medication coat 3 at cradling piece 12 outer wall 121 of intravascular stent body 1 and sidewall 122, within it wall 123 does not have the formation of medication coat 3, that is to say that the inwall at blood vessel coating bracket is without medication coat 3.
If the outer surface of the inwall of intravascular stent body 1 and mandrel 2 is part contact, the 5th kind of embodiment in above step S02, between two surfaces of part contact, there is gap, in follow-up spray treatment process, medication coat liquid can by the gap that formed between inboard wall groove and the mandrel 2 of intravascular stent body 1 or/and the gap that between inwall and the mandrel 2 of intravascular stent body 1, chamfering is formed, as entered, Fig. 9 further groove 124 place and Figure 10 form in the gap at chamfering 125 place and in dry run medication coat 3, meanwhile, medication coat liquid also can be prevented from entering the seamless contact portion between the inwall of intravascular stent body 1 and the outer surface of mandrel 2, seamless contact portion as shown in figure 11.Therefore, after to be dried and after removing mandrel 2, contact portion that this is seamless does not have the formation of medication coat 3, has gap portion then to form medication coat 3 at two contact surfaces, so that be formed with discontinuous medication coat 3 on cradling piece 12 inwall 123 of intravascular stent body 1, such as Figure 12, shown in 14.Certainly, now medication coat 3 is formed at cradling piece 12 outer wall 121 of intravascular stent body 1 and sidewall 122.
In this step S03, the mode that the mode that medication coat liquid is sprayed on intravascular stent body 1 preferably sprays sprays, concrete can select ultrasonic spraying coating process spraying medication coat liquid, its technique is as shown in figure 15, according to the method for above step S02 by mandrel 2 through in intravascular stent body 1 and make that mandrel 2 outer surface is seamless with inwall two contact surface of intravascular stent body 1 to be contacted or after part contact, mandrel 2 one end is fixed on rotation axle 4, is driven intravascular stent body 1 to rotate by rotating axle 4 and move back and forth along the axis direction of mandrel 2.Nozzle 5 for spraying medication coat liquid is fixed on directly over intravascular stent body 1, and medication coat liquid processes then through ultrasonic atomizing device 6 ultrasonic atomizatio after nozzle 5 sprays so that the medication coat liquid of atomization sprays on intravascular stent body 1.Owing to the medication coat liquid drop after atomization is very little, easily enter each position of intravascular stent body 1 after above-mentioned steps S02 processes, as entered in the gap between the inwall of the intravascular stent body 1 in the third embodiment of above step S02 and mandrel 2 outer surface, therefore can obtain the outer wall of intravascular stent body 1, sidewall has medication coat, and inwall has the blood vessel coating bracket of discontinuous medication coat.Wherein, the discontinuous medication coat of inwall may refer to, and this medication coat includes some subregions spaced apart from each other；May also mean that, medication coat only has one piece, and this inwall is not completely covered.
This medication coat liquid is sprayed at the amount on intravascular stent body 1 and can be controlled according to the needs of actual production, in a preferred embodiment, the amount that this medication coat liquid is sprayed on intravascular stent body 1 is that after process to be dried, the thickness of formation medication coat 3 is 2～30 μm.
Containing active constituents of medicine and/or polymer in this step S03 Chinese medicine coating solution.In a preferred embodiment, the Solute mass concentration of this medication coat liquid is 0.1～20%, and this preferred concentration is conducive to the spraying of this medication coat liquid, is particularly conducive to spraying.Wherein, when in this medication coat liquid containing active constituents of medicine time, the content of this active constituents of medicine be preferably in medication coat 3 content be that 2～30 μ g/mm(are in stent length)
In a particular embodiment, this active constituents of medicine is one or more complex in anti-hamartoplasia class medicine, anti-platelet drug, antithrombus formation class medicine, anti-inflammatory response class medicine；Wherein, anti-hamartoplasia class medicine can but be not only rapamycin, paclitaxel etc., anti-platelet drug can but be not only cilostazol (Cilostazol), antithrombus formation class medicine can but be not only heparin, anti-inflammatory response class medicine can but be not only dexamethasone.
In another specific embodiment, when medication coat liquid contains polymer, this polymer is the copolymer of lactide, Acetic acid, hydroxy-, bimol. cyclic ester, the homopolymer of ε-caprolactone or the copolymer of the two or three；Or polybutyl methacrylate, cellulose family, at least one in polyvidon, polyvinyl alcohol, polymethyl methacrylate, gelatin, arabic gum.
Can should prevent vascular restenosis from occurring preferably containing active constituents of medicine and polymer preferred kind, be beneficial to the endothelialization of blood vessel coating bracket, it is ensured that blood fortune was unimpeded.
In still another embodiment, the solvent of medication coat liquid is at least one in oxolane, dichloromethane, chloroform, ethyl acetate, dimethylformamide, chloroform, trichloroethane.Other solvents that can dissolve active constituents of medicine and/or polymer can certainly be selected.
In this step S03, the purpose of the dried after spray treatment is so that the medication coat liquid sticked on intravascular stent body 1 dries formation medication coat 3, and the mode of its dried can adopt the drying mode of routine, such as normal temperature drying or drying.After process to be dried, according to the hardness of the surfacing of mandrel 2 or to be arranged in the mode in intravascular stent body 1 according to mandrel 2 different and different for the taking-up mode of mandrel 2, as when mandrel 2 be according to above step S02 in the mode of first and second kind of embodiment be arranged in intravascular stent body 1 time, in dried process, the top layer 21 expanded can lose the solvent of absorption and cause that its diameter reduces recovery, therefore, mandrel 2 can directly be extracted after drying out；When mandrel 2 be according to above step S02 in the mode of third and fourth kind of embodiment be arranged in intravascular stent body 1 time, after process to be dried, again mandrel 2 is applied external pulling force, mandrel 2 deformed diameter is diminished, now directly this mandrel 2 is extracted out from the hollow cavity 11 of intravascular stent body 1；When mandrel 2 be according to above step S02 in the mode of the 5th kind of embodiment be arranged in intravascular stent body 1 time, after process to be dried, directly mandrel 2 is applied external force, directly this mandrel 2 is extracted out from the hollow cavity 11 of intravascular stent body 1.
From the above, blood vessel coating bracket preparation method provided by the invention can be passed through to control contacting of mandrel 2 surface and intravascular stent body 1 inwall two contact surface, and outer wall can be prepared in conjunction with traditional spraying coating process, sidewall has medication coat, and inwall without medication coat or is formed with the blood vessel coating bracket that the inwall medication coat of discontinuous medication coat is controlled.And be particluarly suitable for being at least on this class intravascular stent body 1 that portion support bar 12 inwall not exclusively overlaps with the circular arc of intravascular stent body 1 internal diameter and form the medication coat that inwall is controlled.
Correspondingly, the embodiment of the present invention additionally provides blood vessel coating bracket, and this blood vessel coating bracket can adopt blood vessel coating bracket preparation method mentioned above to prepare.Therefore, this blood vessel coating bracket includes intravascular stent body and the coating being combined on this intravascular stent body surface and side, wherein, the structure of intravascular stent body such as Fig. 4, the intravascular stent body 1 shown in 5, and without medication coat 3 or it is coated with discontinuous medication coat 3 at this intravascular stent body 1 inwall, such as Fig. 7, shown in 12 and 14.Wherein, this medication coat 3 can be made up of the first coating and the second coating, and, the second coating is coated with and the appearance of the first coating.
Active constituents of medicine in the material of this medication coat 3 also medication coat liquid as noted above and/or polymer, in a preferred embodiment, the thickness of this medication coat 3 is 2～30 μm.When this medication coat 3 is containing active constituents of medicine, it is 2～30 μ g/mm that the content of this active constituents of medicine is preferably in medication coat content.
Owing to without medication coat or being formed with discontinuous medication coat at this blood vessel coating bracket inwall, effectively reduce the amount of the medication coat of this blood vessel coating bracket inwall, therefore, after being entered blood vessel, can both play the effect suppressing vascular restenosis, support endothelialization will not be suppressed again or bring other side effect.
Below by way of specific embodiment, embodiment of the present invention blood vessel coating bracket and preparation method thereof is described further.
Embodiment 1
A kind of blood vessel coating bracket and preparation method thereof, this blood vessel coating bracket preparation method is as follows:
S11: prepare a mandrel 2, as shown in Figure 4, this mandrel 2 is made up of stainless steel bar 22 and the silicone rubber tube 21 being coated on stainless steel bar 22 surface, and the shore hardness D value of silicone rubber is 50, and this mandrel 2 external diameter is 0.9mm；Thering is provided the metallic stent body in as shown in Figure 4 and intravascular stent body 1, its internal diameter is 1.0mm simultaneously, and the cross section of its cradling piece 12 is that edge has the trapezoidal of chamfering；
S12: put into together after mandrel 2 is arranged in the hollow cavity 11 of metallic stent body 1 and take out after soaking 2min in normal heptane, silicone rubber expands after absorbing normal heptane, metallic stent body 1 size constancy, so that silicone rubber tube 21 outer wall contacts with wall seamless in the cradling piece 12 of metallic stent body 1, as shown in Figure 5, basis of microscopic observation cradling piece 12 inwall is uniformly embedded into silicone rubber tube 21 outer surface, form the interface 13 of seamless contact, the edge 14 that cradling piece 12 contacts with mandrel 2 does not have gap, as shown in Figure 6.
S13: metallic stent body 1 and mandrel 2 are fixed on rotation axle 4 as shown in figure 15, it is rotated by rotating axle 4 and moves back and forth along the axial direction rotating axle 4, drug coating solution by be fixed on above metallic stent body 1 through nozzle 5 spray after then through ultrasonic atomizing device 6 ultrasonic atomizatio, drop on rack surface, by the metallic stent body 1 after spraying together with mandrel 2 dry at least 5min in atmosphere, after the normal heptane volatilization of absorption in silicone rubber tube 21, external diameter diminishes, take off mandrel 2, cradling piece 12 outer wall 121 obtained, sidewall 122 is formed with medication coat 3, inwall 123 is without the one side coating blood vessel coating bracket of medication coat 3, as shown in Figure 7.Wherein, drug coating solution is the tetrahydrofuran solution containing rapamycin, and the content of rapamycin is 5%；Ultrasonic spraying equipment is model is the ultrasonic spraying instrument of Medicoat2000, and its ultrasonic power is set to 0.5～1.5w；Be sprayed on cradling piece 12 outer wall 121 through drug coating solution, the thickness of medication coat 3 that sidewall 122 is formed is 20 μm.
Embodiment 2
A kind of blood vessel coating bracket and preparation method thereof, this blood vessel coating bracket preparation method is as follows:
S21: provide a metallic blood vessel bracket, internal diameter is 10mm, prepares a mandrel 2, and this mandrel 2 is slightly less than the polytetrafluoroethylene (PTFE) rod of metallic stent body internal diameter for external diameter, and the shore hardness D of this PTFE rod is 90；The structure of this metallic stent body is metallic stent body 1 in embodiment 1；
S22: after mandrel 2 is arranged in the hollow cavity 11 of metallic stent body, the metallic stent body being equipped with mandrel 2 is put into pressure hold in machine pressure and hold process, metallic stent body diameter diminishes and PTFE mandrel 2 size constancy, owing to PTFE mandrel 2 is harder, pressure holds rear metallic stent body size rebound phenomenon, and cradling piece 12 cross section of metallic stent body can present irregular shape, although macroscopic view cradling piece 12 inwall contacts with PTFE rod and the outer wall seamless of mandrel 2, but examine under a microscope, there is gap in metallic stent body inwall and PTFE rod outer wall, as shown in Figure 8, AA from Fig. 8, BB, CC does sectional view in tri-positions, see Fig. 9 respectively, 10, 11.There is groove 124 in AA place cradling piece 12 inwall mid portion, yet suffers from gap after contacting with mandrel 2 surface；There is the defect of certain chamfering 125 in cradling piece 12 edge, BB place, there is also gap with mandrel 2 after contact, CC place cradling piece 12 inwall is lucky and mandrel 2 surface fully in contact with；
S23: metallic stent body and mandrel 2 are fixed on rotation axle 4 as shown in figure 15, it is rotated by rotating axle 4 and moves back and forth along the axial direction rotating axle 4, drug coating solution by be fixed on above metallic stent body through nozzle 5 spray after then through ultrasonic atomizing device 6 ultrasonic atomizatio, drop on rack surface, metallic stent body after spraying is put into together with mandrel 2 dry at least 10min in the baking oven of 30～60 DEG C, take out PTFE rod, cradling piece 12 outer wall obtained, sidewall is formed with medication coat 3, inwall is formed with the blood vessel coating bracket of discontinuous medication coat 3, as shown in figure 12.Wherein, drug coating solution is containing the polymer that mass ratio is 4:6 and heparin mixture, and wherein the weight/mass percentage composition of polymer is 5%；Ultrasonic spraying equipment is model is the ultrasonic spraying instrument of Medicoat2000, and its ultrasonic power is set to 0.5～1.5w；Being sprayed on cradling piece 12 outer wall, sidewall and internal partial wall through drug coating solution, the thickness of the medication coat 3 formed is about 50 μm.
Embodiment 3
A kind of blood vessel coating bracket and preparation method thereof, this blood vessel coating bracket preparation method is as follows:
S31 a: mandrel 2 is provided, internal diameter is 4.5mm, and as shown in Figure 4 in metallic stent body, internal diameter is 5mm, i.e. intravascular stent body 1, and this mandrel 2 is stainless steel bar, and its external diameter is slightly less than the internal diameter of metallic stent body；
S32: after mandrel 2 is arranged in the hollow cavity of metallic stent body, the metallic stent body being equipped with mandrel is put into pressure hold in machine pressure and hold process, metallic stent body diameter diminishes and stainless steel bar size constancy, owing to stainless steel bar is harder, pressure holds rear metallic stent body size rebound phenomenon, and cradling piece 12 cross section of metallic stent body can present irregular shape, examine under a microscope, gap is there is in metallic stent body inwall with stainless steel bar and mandrel 2 outer wall, as shown in figure 13, specifically, cradling piece 12 inwall occurs that chamfering 125 occur in groove 124 and its；
S33: metallic stent body and mandrel 2 are fixed on rotation axle 4 as shown in figure 15, it is rotated by rotating axle 4 and moves back and forth along the axial direction rotating axle 4, drug coating solution by be fixed on above metallic stent body through nozzle 5 spray after then through ultrasonic atomizing device 6 ultrasonic atomizatio, drop on rack surface, metallic stent body after spraying is put into together with mandrel 2 dry at least 5min in the baking oven of 30～60 DEG C, take out PTFE rod, cradling piece 12 outer wall obtained, sidewall is formed with medication coat 3, inwall is formed with the blood vessel coating bracket of discontinuous medication coat 3, as shown in figure 14.Wherein, drug coating solution is the mixture containing polymer and rapamycin, and its mass content percentage composition is 1%；Ultrasonic spraying equipment is model is the ultrasonic spraying instrument of Medicoat2000, and its ultrasonic power is set to 0.5～1.5w；The coating layer thickness being sprayed on cradling piece through drug coating solution is about 35 μm.
Embodiment 4
A kind of blood vessel coating bracket and preparation method thereof, this blood vessel coating bracket preparation method is as follows:
S41: prepare a mandrel, this mandrel is external diameter is the butadiene rubber pipe of shore hardness D50 of 3.1mm；Thering is provided the metallic stent body in as shown in Figure 4 and intravascular stent body 1, its internal diameter is 3.0mm simultaneously；
S42: the mandrel of butadiene rubber pipe is carried out stretch processing, its outside dimension is made to diminish, after making it be arranged in the hollow cavity of metallic stent body during lower than below 3.0mm, remove the external force of stretching action, butadiene rubber pipe outside dimension is recovered to original size, then metallic stent body inwall contacts with the outer wall seamless of butadiene rubber pipe, and basis of microscopic observation finds, metallic stent body cradling piece inwall is uniformly embedded into butadiene rubber pipe outer wall；
S43: metallic stent body and butadiene rubber tube core axle are fixed on rotation axle 4 as shown in figure 15, it is rotated by rotating axle 4 and moves back and forth along the axial direction rotating axle 4, drug coating solution by be fixed on above metallic stent body 1 through nozzle 5 spray after then through ultrasonic atomizing device 6 ultrasonic atomizatio, drop on rack surface, when medication coat thickness reaches 15 μm, stop spraying, again apply butadiene rubber pipe to stretch after external force is stretched to take out from metallic stent body cavity, obtain the cradling piece outer wall of metallic stent body, sidewall has medication coat, inwall is without the blood vessel coating bracket of medication coat.Wherein, drug coating solution is the ethyl acetate solution containing 3% polylactic acid and 3% rapamycin；Ultrasonic spraying equipment is model is the ultrasonic spraying instrument of Medicoat2000, and its ultrasonic power is set to 0.5～1.5w；The coating layer thickness being sprayed on cradling piece through drug coating solution is about 20 μm.
Embodiment 5
A kind of blood vessel coating bracket and preparation method thereof, this blood vessel coating bracket preparation method is as follows:
S51: provide a mandrel 2 and as shown in Figure 4 in internal diameter be 1.6mm metallic stent body and intravascular stent body 1；Wherein, this mandrel 2 includes the rustless steel cylindrical body that diameter is 1.3mm, after periphery coats lubricating oil, politef (PTFE) thin film that thickness is 0.01mm is uniformly rolled in rustless steel periphery, the shore hardness of this PTFE film is 30, it is wound around through multilayer PTFE membrane, until the gross thickness of rustless steel periphery PTFE film is at least 0.2mm；
S52: after mandrel is arranged in the hollow cavity of metallic stent body, the metallic stent body being equipped with mandrel is put into pressure hold in machine pressure and hold process, metallic stent body diameter diminishes until its inwall is seamless with the PTFE thin film of mandrel contacts, examine under a microscope, the cradling piece cross section of metallic stent body is the irregular square with chamfering, and metallic stent body inwall has been uniformly embedded in PTFE film；
S53: metallic stent body and mandrel are fixed on rotation axle 4 as shown in figure 15, it is rotated by rotating axle 4 and moves back and forth along the axial direction rotating axle 4, drug coating solution by be fixed on above metallic stent body 1 through nozzle 5 spray after then through ultrasonic atomizing device 6 ultrasonic atomizatio, drop on rack surface, after spraying contact, take off stainless steel column, then by PTFE film stretcher strain, thus so as to separate with rack inner wall, the metallic stent body outer wall obtained and sidewall have medication coat, inwall not to have the blood vessel coating bracket of medication coat.Wherein, drug coating solution is the PLA solution containing mass percentage concentration 0.1%～15%, and in another embodiment, this PLA solution is 0.1%～10%；Ultrasonic spraying equipment is model is the ultrasonic spraying instrument of Medicoat2000, and its ultrasonic power is set to 0.5～1.5w；The coating layer thickness being sprayed on cradling piece through drug coating solution is about 5 μm.
Embodiment 6
Outer wall and the sidewall prepare embodiment 5 have the first coating, inwall does not have the one side coating bracket of the first coating, it is directly anchored to rotate on axle 4, support tube intracavity spindle-less, then carries out even application to whole cradling piece, and spray solution is containing polylactic acid 0.5%, after spraying terminates, obtain the support with two layers of coatings, be namely also formed with the second coating (polymer coating) at the first coating surface, and the second coating covers the outer wall of this one side coating bracket, inwall and sidewall.Final support outer wall total coating thickness about 15 μm, spraying instrument parameter is with embodiment 5.
Embodiment 7
A kind of blood vessel coating bracket and preparation method thereof, this blood vessel coating bracket preparation method is as follows:
S71: providing internal diameter is 1.2mm metallic stent body and intravascular stent body 1；Being directly anchored to by support on spraying instrument rotating shaft 4, whole support is sprayed, spray solution contains the polylactic acid of 0.5%, and obtaining inside and outside wall all has the support of the second coating, and the second coating layer thickness is 10～15 μm.
S72: provide mandrel 2 to include the rustless steel cylindrical body that diameter is 1.0mm, after periphery coats lubricating oil, politef (PTFE) thin film that thickness is 0.01mm is uniformly rolled in rustless steel periphery, the shore hardness of this PTFE film is 30, it is wound around through multilayer PTFE membrane, until the gross thickness of rustless steel periphery PTFE film is at least 0.2mm；
S73: after mandrel being arranged in the hollow cavity of the S71 cated metallic stent body prepared, the metallic stent body being equipped with mandrel is put into pressure hold in machine pressure and hold process, metallic stent body diameter diminishes until its inwall is seamless with the PTFE thin film of mandrel contacts, examine under a microscope, the cradling piece cross section of metallic stent body is the irregular square with chamfering, and metallic stent body inwall has been uniformly embedded in PTFE film；
S74: metallic stent body and mandrel are fixed on rotation axle 4 as shown in figure 15, it is rotated by rotating axle 4 and moves back and forth along the axial direction rotating axle 4, drug coating solution by be fixed on above metallic stent body 1 through nozzle 5 spray after then through ultrasonic atomizing device 6 ultrasonic atomizatio, drop on rack surface, after spraying contact, take off stainless steel column, then by PTFE film stretcher strain, thus so as to separate with rack inner wall, the metallic stent body obtained has two layers of coatings, namely the second coating is polymer coating, it is distributed in the inwall of rack body, outer wall and sidewall, first coating is medication coat, and first coating be only distributed in outer wall and sidewall, namely the outer wall of whole support and sidewall have medication coat, inwall only has polymer coating without medication coat.This drug coating solution is the rapamycin of the polylactic acid containing mass percentage concentration 3% and 3%, and ultrasonic spraying equipment is model is the ultrasonic spraying instrument of Medicoat2000, and its ultrasonic power is set to 0.5～1.5w；The coating layer thickness being sprayed on the outer wall of cradling piece through drug coating solution is about 20 μm.
Comparative example
Obtain the intravascular stent body in embodiment 1, cavity body does not wear mandrel wherein, but directly this intravascular stent body is directly anchored on rotation axle 4 as shown in figure 15, the speed with 100～300r/min is driven to rotate and move back and forth along the axial direction rotating axle 4 by rotating axle 4, drug coating solution by be fixed on above metallic stent body 1 through nozzle 5 spray after then through ultrasonic atomizing device 6 ultrasonic atomizatio, drop on rack surface, being dried by metallic stent body 1 after spraying, the blood vessel coating bracket surfaces externally and internally obtained has uniform coating.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all any amendment, equivalent replacement and improvement etc. made within the spirit and principles in the present invention, should be included within protection scope of the present invention.
Claims (10)
1. a blood vessel coating bracket preparation method, comprises the steps:
Being run through by mandrel in the cavity of intravascular stent body coaxially, the shore hardness D of described mandrel top layer or entirety is less than 60；
Change the outer surface of described mandrel and the gap of described intravascular stent inwall, until both seamless contacts；
Coating solution is sprayed at described intravascular stent body；With
Remove described mandrel；
Wherein, elastic deformation can be there is in described top layer, and external diameter is more than the internal diameter of described intravascular stent body, described being run through coaxially by mandrel in described cavity includes with the gap within described intravascular stent with the outer surface of the described mandrel of change: stretch the described mandrel external diameter to described mandrel less than described internal diameter；By described mandrel through described intravascular stent body coaxially；Remove stretching action and recover deformation to described mandrel；Or
Described outside diameter of mandrel substantially mates with the internal diameter of described intravascular stent body, the outer surface of the described mandrel of described change and the gap within described intravascular stent include: be placed in by the intravascular stent body being through with described mandrel in reagent and soak, until described mandrel top layer is expanded to described mandrel outer surface and contacts with the interior wall seamless of intravascular stent body or take out from described reagent after part contact.
2. a blood vessel coating bracket preparation method, comprises the steps:
Being run through by mandrel in the cavity of intravascular stent body coaxially, the shore hardness D of described mandrel top layer or entirety is more than 86；
Change the outer surface of described mandrel and the gap of described intravascular stent inwall, until both part contact；
Coating solution is sprayed at described intravascular stent body；With
Remove described mandrel；
Wherein, elastic deformation can be there is in described top layer, and external diameter is more than the internal diameter of described intravascular stent body, described being run through coaxially by mandrel in described cavity includes with the gap within described intravascular stent with the outer surface of the described mandrel of change: stretch the described mandrel external diameter to described mandrel less than described internal diameter；By described mandrel through described intravascular stent body coaxially；Remove stretching action and recover deformation to described mandrel；Or
Described outside diameter of mandrel substantially mates with the internal diameter of described intravascular stent body, the outer surface of the described mandrel of described change and the gap within described intravascular stent include: be placed in by the intravascular stent body being through with described mandrel in reagent and soak, until described mandrel top layer is expanded to described mandrel outer surface and contacts with the interior wall seamless of intravascular stent body or take out from described reagent after part contact.
3. blood vessel coating bracket preparation method as claimed in claim 1 or 2, it is characterised in that described preparation method is additionally included in and is run through coaxially by mandrel before in described cavity, and at least one wall forms coating in the outer wall of described intravascular stent body, inwall and sidewall.
4. blood vessel coating bracket preparation method as claimed in claim 1 or 2, it is characterised in that described preparation method is additionally included in the coating surface formation coating that described coating solution is formed.
5. blood vessel coating bracket preparation method as claimed in claim 1 or 2, it is characterised in that described coating solution is sprayed at described intravascular stent body outer surface with ultrasonic spraying coating process, and ultrasonic power is 0.5～1.5w.
6. blood vessel coating bracket preparation method as claimed in claim 1 or 2, it is characterised in that the internal diameter of described blood vessel coating bracket body is not equal to the radius of curvature of described blood vessel coating bracket inner body wall.
7. blood vessel coating bracket preparation method as claimed in claim 1 or 2, it is characterized in that, described blood vessel coating bracket includes blood vessel coating bracket body and is formed at the first coating of described blood vessel coating bracket body outer wall and sidewall, it is characterized in that, described blood vessel coating bracket also includes the second coating, described second coating is positioned at described first coating surface, or between described first coating and described intravascular stent body outer surface, the internal diameter of described blood vessel coating bracket body is not equal to the radius of curvature of described blood vessel coating bracket inner body wall, coating on described inwall includes some subregions, it is spaced from each other between each subregion.
8. blood vessel coating bracket preparation method as claimed in claim 7, it is characterised in that described first coating also covers the internal partial wall of described blood vessel coating bracket body.
9. blood vessel coating bracket preparation method as claimed in claim 7, it is characterised in that described second coating covers at least one wall in described outer wall, sidewall and inwall.
10. the blood vessel coating bracket preparation method as described in as arbitrary in claim 8-9, it is characterised in that described first coating and the second coating are all medication coat；Or described first coating is medication coat, described second coating is non-drug coating；Or described first coating and the second coating are all polymer coating.
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| CN114983643A (en) * | 2017-08-14 | 2022-09-02 | 波士顿科学国际有限公司 | Medical support |
| CN108404226A (en) * | 2018-05-25 | 2018-08-17 | 姜香 | A kind of preparation method of high-compatibility coating bracket material |
| CN109316631B (en) * | 2018-09-18 | 2021-04-20 | 曾祥军 | Preparation method of biological source vein containing venous valve |
| CN111358603A (en) * | 2018-12-25 | 2020-07-03 | 元心科技(深圳)有限公司 | Medicine eluting apparatus and manufacturing method thereof |
| CN111388152B (en) * | 2018-12-27 | 2021-12-03 | 元心科技(深圳)有限公司 | Drug eluting device and preparation method thereof |
| CN111388155A (en) * | 2018-12-28 | 2020-07-10 | 先健科技(深圳)有限公司 | Implantable stent system |
| CN114570597B (en) * | 2022-02-21 | 2023-06-30 | 上海心玮医疗科技股份有限公司 | Coating auxiliary device and coating method for dense net support |
| CN115887789A (en) * | 2022-05-26 | 2023-04-04 | 上海微密医疗科技有限公司 | Preparation method of anti-platelet adhesion and anti-hyperplasia stent and stent |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806857A (en) * | 2005-01-17 | 2006-07-26 | 李庆范 | Multilayer-coated stent for controlled drug release and manufacturing method thereof |
| US7553377B1 (en) * | 2004-04-27 | 2009-06-30 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for electrostatic coating of an abluminal stent surface |
| CN201299672Y (en) * | 2008-12-01 | 2009-09-02 | 谢建 | Support mandrel system for spray coating drug-coated stent |
| US7588642B1 (en) * | 2004-11-29 | 2009-09-15 | Advanced Cardiovascular Systems, Inc. | Abluminal stent coating apparatus and method using a brush assembly |
| CN102310034A (en) * | 2010-07-01 | 2012-01-11 | 深圳市金瑞凯利生物科技有限公司 | Method for implementing process of ensuring vascular drug stent to have thick outer coating and thin inner coating |
| CN102448406A (en) * | 2009-09-30 | 2012-05-09 | 泰尔茂株式会社 | Stent |
| WO2013095817A1 (en) * | 2011-12-21 | 2013-06-27 | Edwards Lifesciences Corporation | Apparatus and method for stent shaping |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7198675B2 (en) * | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
| US8453598B2 (en) * | 2006-07-20 | 2013-06-04 | Abbott Cardiovascular Systems Inc. | Stent holding fixtures |
-
2013
- 2013-12-31 CN CN201310752335.4A patent/CN103705324B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7553377B1 (en) * | 2004-04-27 | 2009-06-30 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for electrostatic coating of an abluminal stent surface |
| US7588642B1 (en) * | 2004-11-29 | 2009-09-15 | Advanced Cardiovascular Systems, Inc. | Abluminal stent coating apparatus and method using a brush assembly |
| CN1806857A (en) * | 2005-01-17 | 2006-07-26 | 李庆范 | Multilayer-coated stent for controlled drug release and manufacturing method thereof |
| CN201299672Y (en) * | 2008-12-01 | 2009-09-02 | 谢建 | Support mandrel system for spray coating drug-coated stent |
| CN102448406A (en) * | 2009-09-30 | 2012-05-09 | 泰尔茂株式会社 | Stent |
| CN102310034A (en) * | 2010-07-01 | 2012-01-11 | 深圳市金瑞凯利生物科技有限公司 | Method for implementing process of ensuring vascular drug stent to have thick outer coating and thin inner coating |
| WO2013095817A1 (en) * | 2011-12-21 | 2013-06-27 | Edwards Lifesciences Corporation | Apparatus and method for stent shaping |
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