CN103550842A - Insulin release device - Google Patents
Insulin release device Download PDFInfo
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- CN103550842A CN103550842A CN201310529200.1A CN201310529200A CN103550842A CN 103550842 A CN103550842 A CN 103550842A CN 201310529200 A CN201310529200 A CN 201310529200A CN 103550842 A CN103550842 A CN 103550842A
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Abstract
The invention discloses an insulin release device, which comprises an input module, an insulin amount module, an insulin release mode module, and an insulin release mechanism, wherein the input module is used for inputting the types of foods, the insulin amount module is used for determining the amount of insulin to be released, the insulin release mode module is used for determining the insulin release mode according to the varieties of foods inputted by the input module, and the insulin release mechanism is used for releasing insulin according to the insulin release mode determined by the insulin release mode module, and the insulin amount determined by the insulin amount module. The device has the advantages that the glucose level of a patient is stably controlled, and the generation and development of diabetic complications are relieved.
Description
Technical field
The present invention relates to medical medicine infusion art, relate in particular to a kind of insulin releasing device.
Background technology
At present, drug release device is widely applied in the middle of disease treatment.For example, having occurred that at present a kind of insulin medicament discharges pen or insulin pump, is exactly a kind of drug release device of pen type, wherein mainly comprises: syringe needle, insulin pen-cartridge, drug release mechanism etc.But, current drug release device only can discharge medicine in patient body, as injection, high-pressure injection etc., cannot provide with the corresponding dose of characteristic and the delivery mode of discharged medicine and control function, its delivery mode is to be mainly discharged into once in user's body.For treating diabetes field, especially the treatment field of type i diabetes, existing this drug release device cannot provide drug dose and delivery mode targetedly, causes patient's blood glucose fluctuated, glycemic control is undesirable, has accelerated developing of complication.
Summary of the invention
In view of this, main purpose of the present invention is to provide a kind of insulin releasing device, to control reposefully patient's blood sugar level.
In order to realize foregoing invention object, main technical schemes of the present invention is:
A releasing device, this device comprises:
Input module, for inputting the kind of food;
Insulin dosage module, for determining the amount of insulin that will discharge;
Insulin delivery mode module, for determining the delivery mode of insulin according to the food species of described input module input;
Drug release mechanism, for according to the determined insulin delivery mode of described insulin delivery mode module and the definite amount of insulin of described insulin dosage module, uelralante.
In a kind of preferred embodiment, described insulin delivery mode module is specifically for storage food kind and the parameter that affects on blood glucose thereof, and the corresponding relation that affects parameter and insulin delivery mode on blood glucose; According to the food species of described input module input, inquire about the affect parameter of this food on blood glucose, according to this, affect corresponding relation described in parameter query, determine the delivery mode of insulin.
In a kind of preferred embodiment, described input module is further used for inputting the quantity of food;
Described insulin delivery mode module is specifically for storage food kind and the parameter that affects on blood glucose thereof, and the corresponding relation that affect parameter and quantity and insulin delivery mode of food on blood glucose; According to the food species of described input module input, inquire about the affect parameter of this food on blood glucose, according to this, affect parameter and described size of food is inquired about described corresponding relation, determine the delivery mode of insulin.
In a kind of preferred embodiment, the affect glycemic index GI that parameter be food of described food on blood glucose.
In a kind of preferred embodiment, described insulin delivery mode module specifically for: storage arranges the mapping table of food species and insulin delivery mode, and the food species of inputting according to described input module is inquired about the insulin delivery mode that this food is corresponding.
In a kind of preferred embodiment, described input module is further used for inputting the quantity of food; Described insulin delivery mode module is specifically for the corresponding relation of storage food kind and quantity and insulin delivery mode; According to food species and the size of food of described input module input, inquire about described corresponding relation, determine the delivery mode of insulin.
In a kind of preferred embodiment, the food species of described input module input has two kinds at least; Described insulin delivery mode module is specifically for determining every kind of insulin delivery mode that food is corresponding; Described drug release mechanism is specifically for according to insulin delivery mode corresponding to described every kind of food, and this kind of amount of insulin that food is corresponding, uelralante.
In a kind of preferred embodiment, described input module is further used for inputting the quantity of food; Described insulin dosage module is further used for: the ratio C HO/INS of storage food kind and sugary index thereof and saccharide and insulin, according to the sugary index corresponding to food species inquiry of described input module input, utilize the size of food of described input module input and the sugary quantity that described sugary Index for Calculation obtains inputted food, the sugary quantity of described food, divided by CHO/INS, is obtained to the amount of insulin that will discharge.
In a kind of preferred embodiment, this device also further comprises Man Machine Interface module, be used for providing editing interface, show the described correspondence relationship information that described insulin delivery mode module is stored, receive the edit instruction of input, according to edit instruction, revise the content in correspondence relationship information described in this.
In a kind of preferred embodiment, between described drug release mechanism and described insulin use-case module and insulin delivery mode module, by wireless signal, communicate.
Compared with prior art, the present invention adopts the kind of input module input food, insulin dosage module is accurately determined the amount of insulin that will discharge, insulin delivery mode module is determined the delivery mode of insulin according to the food species of described input module input, drug release mechanism, according to the determined insulin delivery mode of described insulin delivery mode module and the definite amount of insulin of described insulin dosage module, is carried out uelralante.Adopt device of the present invention, the food species that can take according to patient is determined to the delivery mode of uelralante in patient body, can implement delivery mode targetedly for different food, avoid occurring after the meal too high blood glucose or occur too low blood glucose, be conducive to control reposefully patient's blood sugar level, slow down generation and the development of diabetic complication.
Accompanying drawing explanation
Fig. 1 is a kind of composition schematic diagram of insulin releasing device of the present invention;
Fig. 2 is another composition schematic diagram of insulin releasing device of the present invention.
The specific embodiment
Below by specific embodiments and the drawings, the present invention is described in further details.
Fig. 1 is a kind of composition schematic diagram of insulin releasing device of the present invention.Referring to Fig. 1, this insulin releasing device 100 specifically comprises:
This input module 101 can provide Man Machine Interface, and as devices such as display screen, keyboards, user can pass through these Man Machine Interface input messages, for example, can input the food species that user will take in herein, as steamed bread, rice, Fructus Mali pumilae etc.
Insulin delivery mode module 103, for determining the delivery mode of insulin according to the food species of described input module 101 inputs.
If this drug release mechanism 104 can be that insulin discharges pen or insulin discharges pump etc., described delivery mode can be for example injection system, can be also spray regime etc.This Fig. 1 be take injection system and is described as example, and comprising injection needle 105, drug release mechanism 104 can enter drug injection in patient body by this injection needle 105.Described drug release mechanism 104 can directly stick on patient's skin 110, or can be embedded under patient skin.Certainly, described injection needle can be also the injection device with long duct and syringe needle, syringe needle can be imbedded to patient subcutaneous, drug release mechanism 104 is worn on other positions (as being worn on loins) of patient body, and drug release mechanism 104 is injected medicine in patient body by conduit and syringe needle.
In a kind of preferred embodiment, described insulin delivery mode module 103 is specifically for storage food kind and the parameter that affects on blood glucose thereof, and the corresponding relation that affects parameter and insulin delivery mode on blood glucose; According to the food species of described input module 101 inputs, inquire about the affect parameter of this food on blood glucose, according to this, affect corresponding relation described in parameter query, determine the delivery mode of insulin.
Described food species affects parameter and can have multiplely blood glucose, for example, preferably in embodiment, can adopt glycemic index (GI, glycemic index, glycaemic index).Glycemic index means the ratio of certain food rising blood sugar effect and standard food (being generally glucose) rising blood sugar effect, refers to after human body eats certain food and can cause great blood glucose response.It has reflected that a food can cause blood sugar for human body how many ability that raises conventionally, and glycemic index is by human trial, and most method of evaluating foods is chemical method, therefore also often says that glucose resultant index is a kind of physiologic parameters.
The food of high GI, enters that digestion is fast after gastrointestinal, absorbance is high, and glucose discharges fast, and after glucose enters blood, peak value is high, the height that namely blood glucose rises;
Low GI food, in gastrointestinal the time of staying long, absorbance is low, glucose discharges slowly, glucose enters that peak value after blood is low, decrease speed is also slow, simply says to be exactly that blood glucose is lower.
Therefore,, with glucose resultant index, reasonable arrangement meals, are of great benefit to for regulation and control blood sugar for human body.In general as long as the food of half generates index from hyperglycemia, replace to hypoglycemia patient, just can obtain the effect of significantly improving blood glucose.
Described insulin delivery mode module 103 is the delivery mode that parameter is determined insulin that affects on blood glucose according to food, for example specifically can comprise: set the mapping table that affect parameter value and insulin delivery mode of described food on blood glucose, for example, for GI, as shown in table 1 below, the delivery mode of insulin can also further arrange respectively delivery mode according to the kind of insulin herein, and the amount of insulin that inject is the determined amount of insulin of described insulin dosage module 102:
Table 1
Described full dose injection refers to that injection volume is the determined amount of insulin of described insulin dosage module 102.
The injection of described x minute square wave full dose refers to and in after this x minute, injects equably insulin, and the insulin total amount of injecting is the determined amount of insulin of described insulin dosage module 102; Square wave full dose injection in described y minute in like manner.
Described delay m minute adopts square wave full dose injection in n minute to refer to: postpone after m minute, more even the injected insulin in n minute, the insulin total amount of injecting is the determined amount of insulin of described insulin dosage module 102.
The high GI food that is wherein 55～100 for GI can cause rapidly the rising of post-prandial glycemia, therefore for this group food, can adopt the delivery mode of injecting immediately full dose insulin, the blood glucose that injection is risen rapidly as described in can balancing out as the full dose insulin in body, thus ensure that patient's post-prandial glycemia was in normal range.
For GI, be medium food on the upper side, as the GI food that is 40～54, can cause post-prandial glycemia fast rising, it is rapid that but the speed rising is not so good as high GI food, therefore for this group food, can adopt the delivery mode that postpones a few minutes injection full dose insulin, thereby the insulin level in body can be matched with the blood glucose rate of climb, thereby ensure that patient's post-prandial glycemia was in normal range.
Food for low GI, as the GI food that is 20～39, because saccharide is wherein absorbed and slowly causes patient's post-prandial glycemia to rise slowly by health, if also inject immediately full dose insulin, this full dose insulin can come into force in vivo immediately and reduce rapidly patient's blood sugar level, cause patient that hypoglycemic probability occurs and increase, serious is even in peril of one's life.Therefore for the food of these low GI, can adopt the delivery mode of square wave full dose injection, for example in 60 minutes, equably described amount of insulin is injected in patient body, thereby reach the object that reduces equably patient's blood glucose, avoid occurring hypoglycemia and too high blood glucose, ensure patient's health level.
Above concrete data and concrete delivery mode just illustrate, and when concrete enforcement is of the present invention, multiple delivery mode and described corresponding relation can also be self-definedly set.For example described delivery mode can be also: the release profiles corresponding to the glycemic curve of blood glucose value according to food, carrys out uelralante according to this release profiles.
In a kind of preferred embodiment, described insulin dosage module 102 has input interface, for inputting amount of insulin, using the amount of insulin of this input as the determined amount of insulin that will discharge.Insulin dosage is exactly that this amount of insulin can be estimated and be inputted estimator by user by user, also can adopt following embodiment automatically to calculate for consuming the amount of insulin of the food that user will take in.
In another kind of preferred embodiment, described input module 101 is further used for inputting the quantity of food; Described insulin dosage module 102 is further used for: the ratio (CHO/INS) of storage food kind and sugary index thereof and saccharide and insulin, according to the sugary index corresponding to food species inquiry of described input module 101 inputs, utilize the size of food of described input module 101 inputs and the sugary quantity that described sugary Index for Calculation obtains inputted food, the sugary quantity of described food, divided by CHO/INS, is obtained to the amount of insulin that will discharge.
For example, the sugary index of having stored steamed bread in described insulin dosage module 102 is 50%, if input module 101 inputs " steamed bread ", quantity is " 150 grams ", to inquire the sugary index that steamed bread is corresponding be 50% to insulin dosage module 102, and the sugary quantity of current inputted steamed bread is 150 * 50%=75 gram, if user's CHO/INS is 15, needing the amount of insulin discharging is 75 ÷ 15=5U, the unit that described U is insulin.
In addition because patient tends to the multiple food of taking food at table, so patient can input the amount of insulin of every kind of required consumption of food, or automatically calculates the corresponding amount of insulin consuming of every kind of food by insulin dosage module 102 of the present invention.So for every kind of different food, the present invention can utilize described insulin delivery mode module 103 to determine this kind of insulin delivery mode that food is corresponding, described drug release mechanism 104 is further used for according to insulin delivery mode corresponding to described every kind of food, and this kind of amount of insulin that food is corresponding, uelralante.
That is,, in a kind of preferred embodiment, the food species of described input module 101 inputs has two kinds at least; Described insulin delivery mode module 103 is specifically for determining every kind of insulin delivery mode that food is corresponding; Described drug release mechanism 104 is specifically for according to insulin delivery mode corresponding to described every kind of food, and this kind of amount of insulin that food is corresponding, uelralante.
For example, 400 grams of Rhizoma Solani tuber osis and 150 grams of dried bean curd if user has taken food simultaneously, the sugary index of Rhizoma Solani tuber osi is 17%, the sugary index of dried bean curd is 10%, the contained saccharide of Rhizoma Solani tuber osi of patient's feed is 400 * 17%=68 gram so, and the contained saccharide of dried bean curd of feed is 150 * 10%=15 gram; Suppose patient's CHO/INS=15, it is 68/15=4.53U that the Rhizoma Solani tuber osi of taking food so needs the corresponding amount that consumes insulin, a kind of unit that U is insulin, and it is 15/15=1U that feed dried bean curd needs the corresponding amount that consumes insulin.The GI that supposes Rhizoma Solani tuber osi is 62, and the GI of dried bean curd is 24, so according to table 1, supposes the current employing Rapid-effect insulin of patient, and drug release mechanism 104 can be injected the insulin of 4.53U immediately, then adopts x minute square wave injection 1U insulin.Adopt the insulin delivery mode uelralante combining, make the insulin of injection in patient body, rationally consume the blood glucose that the saccharide in feed food generates, guarantee the steady of patient's blood glucose.
Because the quantity of dietary intake also can affect the appreciation speed of user blood glucose sometimes, so in another kind of embodiment, can on the quantity that affects parameter and food of blood glucose, decide the delivery mode of insulin by combining foods.In this embodiment, described input module 101 is further used for inputting the quantity of food; Described insulin delivery mode module 103 is further used for: storage food kind and the parameter that affects on blood glucose thereof, and the corresponding relation that affect parameter and quantity and insulin delivery mode of food on blood glucose; According to the food species of described input module 101 inputs, inquire about the affect parameter of this food on blood glucose, according to this, affect parameter and described size of food is inquired about described corresponding relation, determine the delivery mode of insulin.As shown in table 2 below:
Table 2
In a kind of more meticulous embodiment, the present invention can also directly store the mapping table that food species and insulin delivery mode are set in described insulin delivery mode module 103, according to the food species of described input module 101 inputs, inquires about the insulin delivery mode that this food is corresponding.As shown in table 3 below:
Table 3
Because the quantity of dietary intake also can affect the appreciation speed of user blood glucose sometimes, therefore in another kind of embodiment, can combining foods kind and the quantity of food decide the delivery mode of insulin.In this embodiment, described input module 101 is further used for inputting the quantity of food, and described insulin delivery mode module 103 is further used for: the corresponding relation of storage food kind and quantity and insulin delivery mode; According to food species and the size of food of described input module 101 inputs, inquire about described corresponding relation, determine the delivery mode of insulin.As shown in table 4 below:
Table 4
And, the present invention also further comprises Man Machine Interface module, be used for providing editing interface, show the described correspondence relationship information that described insulin delivery mode module 103 is stored, correspondence relationship information as described in similar table 1～4, receive the edit instruction of input, according to edit instruction, revise the content in correspondence relationship information described in this.For example, owing to having body constitution difference between different user, so user can utilize this Man Machine Interface module to revise certain GI scope or insulin delivery mode corresponding to food species, or revises GI scope or the food species that certain insulin delivery mode is corresponding.
In addition, described Man Machine Interface module can also be for providing editing interface, show food species that described insulin dosage module 102 is stored and the ratio C HO/INS of sugary index and saccharide and insulin thereof, receive the edit instruction of input, according to edit instruction, revise 102 canned datas of this insulin dosage module.Such as user, can revise described CHO/INS etc.
In above-described embodiment, between described drug release mechanism 104 and insulin use-case module and insulin delivery mode module 103, can be wire communication, can be also radio communication.If Fig. 2 is another composition schematic diagram of intellectual drug releasing device of the present invention, in the present embodiment, between described drug release mechanism 104 and other module, it is Split type structure, described drug release mechanism 104 directly sticks on patient's skin 110, or can be embedded under patient skin, between described drug release mechanism 104 and described insulin use-case module and insulin delivery mode module 103, by wireless signal, communicate, facilitate persistence to injectable drug in patient body, if this drug release mechanism 104 can be a kind of syringe pump (as insulin infusion pump etc.) that can sustained release medicine, other module can be integrated in a module 401, separated with described drug release mechanism 104, facilitates user to carry and holds and take, and needn't stick on patient skin or be embedded under patient skin.This separate mode can make patient after having worn the syringe pump of sustained release medicine, both can realize the function of intelligence computation drug dose of the present invention and the various embodiments described above, does not affect again patient's freedom of action, facilitates patient to carry described syringe pump.
In a preferred embodiment of the present invention, described intellectual drug releasing device is that insulin medicament discharges pen.
In another kind of preferred embodiment of the present invention, described intellectual drug releasing device is that insulin medicament discharges pump.
The above; be only the preferably specific embodiment of the present invention, but protection scope of the present invention is not limited to this, any people who is familiar with this technology is in the disclosed technical scope of the present invention; the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.
Claims (10)
1. an insulin releasing device, is characterized in that, this device comprises:
Input module, for inputting the kind of food;
Insulin dosage module, for determining the amount of insulin that will discharge;
Insulin delivery mode module, for determining the delivery mode of insulin according to the food species of described input module input;
Drug release mechanism, for according to the determined insulin delivery mode of described insulin delivery mode module and the definite amount of insulin of described insulin dosage module, uelralante.
2. insulin releasing device according to claim 1, is characterized in that,
Described insulin delivery mode module is specifically for storage food kind and the parameter that affects on blood glucose thereof, and the corresponding relation that affects parameter and insulin delivery mode on blood glucose; According to the food species of described input module input, inquire about the affect parameter of this food on blood glucose, according to this, affect corresponding relation described in parameter query, determine the delivery mode of insulin.
3. insulin releasing device according to claim 1, is characterized in that,
Described input module is further used for inputting the quantity of food;
Described insulin delivery mode module is specifically for storage food kind and the parameter that affects on blood glucose thereof, and the corresponding relation that affect parameter and quantity and insulin delivery mode of food on blood glucose; According to the food species of described input module input, inquire about the affect parameter of this food on blood glucose, according to this, affect parameter and described size of food is inquired about described corresponding relation, determine the delivery mode of insulin.
4. according to the device described in claim 2 or 3, it is characterized in that the affect glycemic index GI that parameter be food of described food on blood glucose.
5. insulin releasing device according to claim 1, is characterized in that,
Described insulin delivery mode module specifically for: storage arranges the mapping table of food species and insulin delivery mode, and the food species of inputting according to described input module is inquired about the insulin delivery mode that this food is corresponding.
6. insulin releasing device according to claim 1, is characterized in that,
Described input module is further used for inputting the quantity of food;
Described insulin delivery mode module is specifically for the corresponding relation of storage food kind and quantity and insulin delivery mode; According to food species and the size of food of described input module input, inquire about described corresponding relation, determine the delivery mode of insulin.
7. insulin releasing device according to claim 1, is characterized in that,
The food species of described input module input has two kinds at least;
Described insulin delivery mode module is specifically for determining every kind of insulin delivery mode that food is corresponding;
Described drug release mechanism is specifically for according to insulin delivery mode corresponding to described every kind of food, and this kind of amount of insulin that food is corresponding, uelralante.
8. insulin releasing device according to claim 1, is characterized in that,
Described input module is further used for inputting the quantity of food;
Described insulin dosage module is further used for: the ratio C HO/INS of storage food kind and sugary index thereof and saccharide and insulin, according to the sugary index corresponding to food species inquiry of described input module input, utilize the size of food of described input module input and the sugary quantity that described sugary Index for Calculation obtains inputted food, the sugary quantity of described food, divided by CHO/INS, is obtained to the amount of insulin that will discharge.
9. insulin releasing device according to claim 1, it is characterized in that, this device also further comprises Man Machine Interface module, be used for providing editing interface, show the described correspondence relationship information that described insulin delivery mode module is stored, receive the edit instruction of input, according to edit instruction, revise the content in correspondence relationship information described in this.
10. insulin releasing device according to claim 1, is characterized in that, between described drug release mechanism and described insulin use-case module and insulin delivery mode module, by wireless signal, communicates.
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| CN1871783A (en) * | 2003-10-24 | 2006-11-29 | Kj健康护理株式会社 | Insulin pump for use in conjunction with mobile coomunication terminal capable of measuring blood glucose levels and network system for transmitting control information for insulin pump |
| US20070112298A1 (en) * | 2005-11-17 | 2007-05-17 | Medtronic Minimed, Inc. | External infusion device with programmable capabilities to time-shift basal insulin and method of using the same |
| WO2010029551A2 (en) * | 2008-09-11 | 2010-03-18 | Medingo Ltd. | Methods and devices for tailoring a bolus delivery pattern |
| CN101877037A (en) * | 2009-06-15 | 2010-11-03 | 张晓峰 | Information processing device, method, corresponding equipment and reagent carrier |
| CN102016855A (en) * | 2008-04-04 | 2011-04-13 | 海吉雅有限公司 | Apparatus for optimizing a patient's insulin dosage regimen |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1871783A (en) * | 2003-10-24 | 2006-11-29 | Kj健康护理株式会社 | Insulin pump for use in conjunction with mobile coomunication terminal capable of measuring blood glucose levels and network system for transmitting control information for insulin pump |
| US20070112298A1 (en) * | 2005-11-17 | 2007-05-17 | Medtronic Minimed, Inc. | External infusion device with programmable capabilities to time-shift basal insulin and method of using the same |
| CN102016855A (en) * | 2008-04-04 | 2011-04-13 | 海吉雅有限公司 | Apparatus for optimizing a patient's insulin dosage regimen |
| WO2010029551A2 (en) * | 2008-09-11 | 2010-03-18 | Medingo Ltd. | Methods and devices for tailoring a bolus delivery pattern |
| CN101877037A (en) * | 2009-06-15 | 2010-11-03 | 张晓峰 | Information processing device, method, corresponding equipment and reagent carrier |
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