CN103405341A - 与药物制品整合的可摄入的事件标记系统 - Google Patents

与药物制品整合的可摄入的事件标记系统 Download PDF

Info

Publication number
CN103405341A
CN103405341A CN2013103150557A CN201310315055A CN103405341A CN 103405341 A CN103405341 A CN 103405341A CN 2013103150557 A CN2013103150557 A CN 2013103150557A CN 201310315055 A CN201310315055 A CN 201310315055A CN 103405341 A CN103405341 A CN 103405341A
Authority
CN
China
Prior art keywords
tablet
pill
pharmaceutical preparation
protective layer
control unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2013103150557A
Other languages
English (en)
Inventor
霍曼·哈菲奇
罗伯特·达克
蒂莫西·罗伯森
本尼迪克特·科斯特洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proteus Digital Health Inc
Original Assignee
Proteus Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus Biomedical Inc filed Critical Proteus Biomedical Inc
Publication of CN103405341A publication Critical patent/CN103405341A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4833—Assessment of subject's compliance to treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861—Capsules, e.g. for swallowing or implanting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6871—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6873—Intestine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/007—Marking tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B38/00—Ancillary operations in connection with laminating processes
    • B32B38/0004—Cutting, tearing or severing, e.g. bursting; Cutter details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/30—Compliance analysis for taking medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/60—General identification or selection means using magnetic or electronic identifications, e.g. chips, RFID, electronic tags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/02—2 layers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/903—Radio telemetry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1062—Prior to assembly
    • Y10T156/1066—Cutting to shape joining edge surfaces only

Abstract

本发明提供一种用于将可摄入电子器件紧固到药物制品上而不损坏所述可摄入电子器件的系统与方法。根据本发明的一方面，所述制品包括置于所述制品上的可摄入电子器件。根据本发明的另一方面，所述可摄入电子器件被置于所述制品的内部。根据本发明公开的各种实施方案是用于保护和/或涂覆所述电子标记以及将所述可摄入电子器件紧固到所述制品上。

Description

与药物制品整合的可摄入的事件标记系统
本申请是名称为“与药物制品整合的可摄入的事件标记系统”、申请日为“2010年12月2日”的中国发明专利申请201080062284.7的分案申请。
交叉引用和相关申请
依据美国法典35篇119条(e)款，本申请要求2009年12月2日提交的题为“与药物制品整合的可摄入的事件标记系统(INTEGRATED INGESTIBLE EVENT MARKERSYSTEM WITH PHARMACEUTICAL PRODUCT)”的美国临时专利申请第61/266,103号的申请日的优先权，所述申请的公开内容以引用的方式并入本文。
本申请涉及并以引用的方式并入下列申请：2010年11月22日提交的题为“使用药物制品的可摄入器件(INGESTIBLE DEVICE WITH PHARMACEUTICALPRODUCT)”的美国临时申请第61/416,150号；2007年10月25日提交的题为“激活受控制的可摄入的标识物(CONTROLLED ACTIVATION INGESTIBLE IDENTIFIER)”的美国申请第12/447,172号；2006年10月25日提交的题为“激活受控制的药物信息系统(CONTROLLED ACTIVATION PHARMA-INFORMATICS SYSTEM)”的美国临时申请第60/862,925号；和，2007年10月25日提交的题为“激活受控制的可摄入的标识物(CONTROLLED ACTIVATION INGESTIBLE IDENTIFIER)”的PCT申请US2007/82563。
技术领域
本发明涉及使用部分电源的电子器件，而更具体地说，涉及紧固到药物制品的电子器件，其中所述电子器件在与导电流体接触时被激活。
背景技术
药物制品以包括药丸的多种形式递送给使用者。由于电子元件的精密性质以及将电子元件紧固到药物制品(如药丸或药片或胶囊)的难度，药物制品与可摄入器件的整合常常是个挑战。例如，药片通常是利用压机向药粉施加压力而制成。由压机产生的压力常常会损坏置于药片或药丸内部的电子元件。此外，利用粘合材料将电子元件紧固到药片的表面常常因所述粘合剂而造成对器件的损坏，所述粘合剂可能是热激活型或化学激活型粘合剂。另外，在装配过程中操纵小型电子器件常常是个挑战。因此，需要用于将可摄入电子器件紧固到药物制品而不损坏所述可摄入电子器件的系统和方法。
发明内容
本发明提供一种用于将可摄入电子器件紧固到药物制品而不损坏所述可摄入电子器件的系统和方法。根据本发明的一方面，所述制品包括置于所述制品上的电子标记。根据本发明的另一方面，所述电子标记被置于所述制品的内部。根据本发明公开的各种实施方案允许对所述电子标记的保护和涂覆。
附图说明
图1示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图1A示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图1B示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图1C示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图2是图1的器件组件的分解图。
图2A是图1A的器件组件的分解图。
图2B是图1B的器件组件的分解图。
图2C是图1B的器件组件的分解图。
图3A示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图3B示出根据本发明的一方面的在一个表面上紧固有器件组件的第一药片部分和紧固在所述器件组件之上的第二药片部分。
图3C示出根据本发明的一方面的具有层合包衣的器件组件。
图4示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图5示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图5A示出图5的药片的装配过程。
图5B示出图5的药片的装配过程。
图6示出根据本发明的一方面的在一个表面上紧固有器件组件的药片。
图6A示出图6的药片的装配过程。
图7示出根据本发明的一方面的在一个表面上紧固有器件组件的药片和包围所述药片的包衣。
图8示出根据本发明的一方面的在一个末端上紧固有器件组件的胶囊。
图9示出根据本发明的一方面的在一个侧表面上紧固有器件组件的胶囊。
图10是根据本发明的一方面的在药片上装配器件的流程图。
图11是根据本发明的一方面的在药片上装配器件的流程图。
图12是根据本发明的一方面的在药片上装配器件的流程图。
图13是根据本发明的一方面的在药片内装配器件的流程图。
图14是用于在药片上装配器件的装配装置。
图15是图14的装置的一部分的部分特写图，特别指明了施加力的方向。
图16是图14的装置的馈料器组件的部分特写图。
图17是根据本发明的另一方面的可与图14的装置一起使用的馈料器组件的部分特写图。
图18A是根据本发明的另一方面的可与图14所述装置一起使用的馈料器组件的部分特写图。
图18B是图18A中示出的馈料器组件在装载过程的后期的部分特写图。
图19是根据本发明的一方面的用于将器件装配到药片上的装配装置。
图20是图19的装配装置的部分特写图。
图21是包括如图19的部分所示的用于将器件装配到药片或药丸上的附加元件的装配装置图。
图22是根据本发明的一方面的压制工具的特写图。
图23A-C示出根据本发明的另一方面的用于将器件装配到药片上的装配装置。
图24A-C示出用于装载图16、图17、图18A和图18B中任何图的馈料器或馈料器组件的过程。
图25示出根据本发明的另一方面的使用将器件装配到药片或药丸上的方法的装配装置。
具体实施方式
本发明公开了将能够指明事件(如摄取)发生的器件紧固到可摄入制品(如药丸或药片形式的药物制品)的多种方法。为更好地理解所涉及的方法和系统，就紧固在所述制品内的器件以及紧固在所述制品外表面上的器件，对所述系统进行更详细地描述。例如，将所述器件紧固到所述制品上的方法可利用压力、温度、化学反应或其组合来完成。根据本发明的一方面，通过本文公开的各种紧固层和保护层来保护所述器件免受这些条件的影响。所用的材料在25-200摄氏度的温度范围内有效，包括80-150摄氏度的目标范围以及在这些温度下的暴露持续时间。暴露时间将从0.1秒变化至50秒，包括1秒至15秒的目标范围。此外，将保护所述器件免受所涉及的力的影响，所述力的范围是1至50磅，包括2-8磅，以及免受在整合器件与药丸期间施加的压力，所述压力范围是100至400PSI。因此，本发明的范畴包括使用材料来保护器件和制品免受与整合所述器件与所述药丸相关的各种环境参数(如压力、时间、力、化学反应和其组合)的影响。
另外，本发明的范畴不受所述制品的形状或类型的限制。例如，所述制品可为药丸，包括胶囊、时间释放的口服剂型、药片、凝胶胶囊、舌下含片或任何口服剂型制品。药丸可单独或组合地含有或单独或组合地由任何下列物质制成：活性剂、药物、安慰剂、维生素或任何食材。根据本发明的一方面，所述制品包括的器件是定位在所述制品的内部或紧固在所述制品的内部。在替代方案中，所述器件被紧固在所述制品的外部。
现参看图1，其示出具有凸面的药丸20的实施例，其中标记组件22紧固在外部。此外，标记组件22与药丸20的形状相适应。在本实施例中，如图2所示，标记组件22包括可摄入的事件标记或离子发射模块(IEM)单元24、下保护层26、上保护层28、粘合剂层或紧固层30以及装饰层或印刷层32。根据本发明的一方面，IEM单元24的不导电外部或裙缘部包括围绕IEM单元24分布的孔24a(如图2A所示)，以便在层26与层28被紧固到或被层合到IEM单元24上时，层26与层28可通过孔24a在连接部25处(如图1A所示)层合在一起。
现参看图1B和图2B，根据本发明的另一方面，图1的保护层26和紧固层30由多个紧固点或部分27预置。如图1C和图2C所示，根据本发明的另一方面，包括保护层26，并且图1的紧固层30由多个紧固点或部分27预置。标记组件22通过空气间隙与药丸20隔开，因此能被紧固到药丸20而无需考虑药丸20的形状，因为点27会变形并调整轮廓以适应药丸20的形状。因此，当药丸20的形状使得标记组件22不能容易地与药丸20的形状适应时，点27就会变形和加以适应。这确保了药丸20的形状与标记组件22的形状之间的紧固连接。点27分布在标记组件22周围并用来将标记组件22连接到药丸20。另外，将每个标记组件22紧固到药丸20所需的紧固材料的厚度或量将会减少。
IEM单元24包括两种不同类材料(未示出)和裙缘部包围的控制单元，每种所述的不同类材料都电连接到所述控制单元并互相隔开。所述不同类材料代表电源的一部分或可被称作部分电源，并在与导电流体接触时，随着材料溶解而在整个材料范围产生电压电势。一旦IEM单元24与导电流体(如见于胃中的体液)进行接触时，那么IEM单元24就被激活并且由溶解到溶液中的不同类材料产生电流，并且随着所述不同类材料从固态变成液态而在材料之间产生电压电势。
根据本发明的另一方面，紧固层30也可由包括粘合与释放性质的层替换。例如，释放功能是通过引入崩解剂(例如羟基乙酸淀粉钠)或水溶性赋形剂(例如羟丙基纤维素)来实现。因此，当组件22变潮湿时，层30会使标记组件22离开药丸20。因此，在本发明提及粘合层或紧固层的层面，本发明的范畴涵盖使用具有粘合性质的层或具有粘合性质和释放性质的层。本发明的范畴不受标记组件22的形状的限制。IEM概念可被扩展到“电流药片(galvanic tablet)”或药物释放速率是通过集成电路(IC)进行电流控制的剂型。所述剂型由芯片组成，该芯片连接到部分电源(如类似于IEM所用材料的CuCl-Mg材料)，也连接到含有药物化合物的基质。一旦被激活，所述IC就通过控制施加到所述基质的电流或电势来控制药物释放的速率。这方面的一个实例是由药物化合物、粘结剂和电化学可溶性材料(例如盐)构成的基质。所述盐电化学转化为可溶性物质侵蚀基质或在基质中产生孔，从而以对应于所传递电荷的精确速率来释放药物。
所述IC可以任何所需速率来控制施加于基质的电荷，例如以便实现持续的药物放出、脉冲释放、逐渐变速（ramp）的药物递送。释放可响应于由所述IC感测到的生理信号，例如局部pH值、阻抗、能动性、在胃肠(GI)道中的位置、出血。也可在外部触发释放，例如，所述IC可包括RF天线，从而允许患者或医疗监视器(例如个人健康陪护(personal health companion)、血液监视器)响应如疼痛的身体病状来启动药物释放。相关的IEM配置包括但不限于以下专利中描述的那些配置：公布为WO/2006/116718的PCT申请第PCT/US2006/016370号、公布为WO/2008/052136的PCT申请第PCT/US2007/082563号、公布为WO/2008/063626的PCT申请第PCT/US2007/024225号、公布为WO/2008/066617的PCT申请第PCT/US2007/022257号、公布为WO/2008/095183的PCT申请第PCT/US2008/052845号、公布为WO/2008/101107的PCT申请第PCT/US2008/053999号、公布为WO/2008/112577的PCT申请第PCT/US2008/056296号、公布为WO/2008/112578的PCT申请第PCT/US2008/056299号、公布为WO2009/042812的PCT申请第PCT/US2008/077753号、美国专利申请第12/546,017号；和美国临时申请第61/142,849号、第61/142,861号、第61/173,511号、第61/173,564号和第61/177,611号；所述申请的公开内容以引用的方式并入本文。
剂型能够提供非常精确的血液药物浓度，用于疼痛管理的快速剂量递送或在胃肠道中的局部递送。医疗应用可以包括胃肠疾病，例如，能动性、结肠炎、疼痛管理、对肿瘤的局部递送、治疗剂(例如免疫抑制剂)的定制给药，以及其它应用。
其它释放机理也有可能：药物基质可以含有电活性的药物结合聚合物，例如Nafion、蛋白质，其电荷状态或溶胀程度可通过施加电流或电势来改变。通过IC施加电势改变聚合物对药物的结合性质以实现药物的释放。另一可能的机理是所述IC控制剂型周围的溶液物质(例如H+)的浓度，这进而可增大/减小所述药物基质的溶解度并调节药物释放。电流也可被施加到所述剂型的外层而不是整个基质来控制包衣的溶解速率。
电源和药物基质可为不同或相同的。例如，基质可以含有作为电化学活性物质的CuCl。CuCl可作为阴极来向所述IC提供电力，也可充当发生转化(转化成铜和氯离子)会释放药物的物质。所述IC的位置可以在所述剂型的主体内或在表面上。传感器可以引入所述IC中并用来触发药物释放或向接收器单元报告生理状况，如PH值、阻抗、化学敏感性、温度(检测出血)。护套、包衣或歧管可用来限制所述基质以使溶解只发生在一个表面，而另一个表面被防止溶解的护套涂覆。也可施加包衣来防止药物释放，直到药物达到胃肠道(例如肠或结肠)内的所需位置为止。
疼痛管理方案的一个实施例是，通常存在长效阿片样物质(例如奥施康定(Oxycontin))结合针对爆发性疼痛的自滴定短效阿片样物质得到的疼痛缓解的基础率。所述范例被用于可注射疗法和口服疗法。本发明可以同一药丸或药丸组来应付基础疼痛和爆发性疼痛，或如果患者还服用标准的长效口服剂，那么可使用本发明专用于爆发性部分。这就涉及将其设想为可摄入患者自控的镇痛系统(类似于住院，基于IV的PCA)。本发明的一方面包括将IEM与用于以下作用的药学非活性的赋形剂材料稳定地联合：1)保护所述IEM免受潮湿、处理和附近环境的影响；和2)保护制剂中别处的活性药物免受所述IEM自身的损坏或降解的影响。可开发一个或多个保护性IEM“夹层”以使最终IEM与赋形剂模块可被可靠地整合到最终药片或胶囊口服剂型中，而对制品溶解作用或稳定性的有害作用风险最小。随着时间的过去，一旦联合活性药物完成对IEM夹层性能的表征，包括例如pH值、溶解作用、生物利用度、溶解度的基本药物特征范围，就可能使规定准许相关的测试IEM-启动的药物疗法现代化，从而在市场独占权并不必依赖于分子物质组合物专利，而依赖于IEM的引入和由这种引入所赋予的伴随能力的情况下，使实质上成为新型的专有药物疗法的上市时间加快。
现参看图3A，其示出具有近乎平面或平坦表面的药丸40，标记组件42紧固在外部。标记组件42与药丸40的形状相适应。在本实施例中，标记组件42包括IEM单元44、下保护层46、上保护层48、粘合剂层或紧固层50以及装饰层或印刷层52.
现参看图3B，根据本发明的另一方面，示出具有第一药片部分41的药丸40。示出的标记组件42a被紧固到所述第一药片部分41的表面。标记组件42a由第二药片部分43覆盖。部分41和部分43可以是类似或不同的材料。例如，根据本发明的一方面，部分41可以为药物制品，而部分43可以为快速溶解材料。标记组件42a可以与图3A中的标记组件42类似，或该标记组件也可以仅仅只是具有下层46和上层48的IEM单元44。
现参看图3B和图3C，根据本发明的另一方面，标记组件42a可由图3C的标记组件42b替换。标记组件42B包括IEM单元44和层合包衣或薄膜包衣45。层合层是由可溶解材料制成，一旦药丸40的部分41和部分43已溶解或崩解以释放标记组件42b，所述可溶解材料就延迟IEM单元44的激活。薄膜包衣45可由各种材料或薄膜制成，如聚合物薄膜，包括聚氧化乙烯、羟丙基纤维素和柠檬酸三乙酯。可用的其它薄膜包括任何可溶解聚合物或增塑剂。薄膜包衣45提供湿分阻挡并在合适的条件下溶解以延迟IEM单元44的激活。相对于药丸40的崩解和分散，薄膜包衣45设计为IEM单元暴露于周围流体时提供足够的延迟。薄膜包衣45可包括任何下列材料：可溶性材料、屏蔽材料(如脂质、聚乙烯醇)、加工助剂(如增塑剂、粘合促进剂)和稳定剂。另外，薄膜包衣45可经由层合作用，施加涂覆溶液或浆液接着固化来制造。例如，根据本发明的一方面，薄膜包衣44可被层合到IEM单元44，其中IEM单元44的裙缘或末端被暴露(如图3A所示)。例如，根据本发明的另一方面，薄膜包衣44可围绕IEM单元44进行层合以形成袋状物，其中IEM单元44的边缘或末端被覆盖(如图3B所示)。根据本发明的其它方面，可利用干式压缩，如压片机来围绕IEM单元44形成薄膜包衣45。
显然所公开的各种层可根据所用材料及其性质而省去或组合。例如，参看图2，下保护层26和紧固层30可组合成单层，这在图4中示出。更具体地说并参看图4，示出了具有凸面的药丸52，但是可使用平面或凹面而不会限制本发明的范畴。标记组件54被紧固到药丸52上。在本实施例中，标记组件54包括下层56、上层58和器件60，如IEM。根据本发明的一方面，下层56是分别组合了图2的层30与层26的粘合性质和保护性质的材料。类似地，上层58是分别组合了图2的层28与层32的保护性质和装饰性质的材料。此外，在本实施例中，标记组件54相对于药丸52来说尺寸不同。本发明的范畴不受本实施例或本文公开的任何其它实施例中的标记组件54的形状或尺寸的限制。
现参看图5，示出具有凸面的药丸62，但可使用平面或凹面而不会限制本发明的范畴。标记组件64被紧固到药丸62上。在本实施例中，标记组件64包括上层66和器件68，如IEM。在本实施例中，粘合剂层及其性质，如图2的粘合剂层30，可以为药丸62上包衣的部分。或者，根据本发明的另一方面，粘合剂层可以为器件68的部分。根据本发明的又一方面，粘合性质可以由上层66在与药丸62的接触点处提供。因此，取决于所选择的材料的性质，可改变每个层的性质以满足如在各种实施例中所示的方面的特定需要。
现参看图5A，其示出根据本发明的一方面将标记组件64装配到药丸62上的工艺。一次一层地将标记组件64构建到药丸62上。将器件68定位于药丸62上。然后，使器件68形成为药丸62的形状。可使用任何标准方法(例如，热和/或压力)使器件68成形为药丸62的形状。然后，增加上层66并使之成形为药丸62的形状，并利用压力和/或热将其紧固到药丸62上。
现参看图5B，其示出根据本发明的另一方面将标记组件64装配到药丸62上的工艺。在本实施例中，标记组件64在被提供给药丸62之前已被装配。将标记组件64定位于药丸62上。然后，利用热和/或压力将标记组件64紧固到药丸62上并使之成形为药丸62的形状。
现参看图6和图6A，在根据本发明另一方面的另一实施例中，药丸70包括凸面，但可使用平面或凹面而不会限制本发明的范畴。利用热和/或压力将标记组件72成形为药丸70的形状并使之紧固到药丸70上。在本实施例中，标记组件72包括器件包衣层74和器件74a，如IEM。在本实施例中，粘合剂层和其性质及保护层和其性质，如图2的粘合剂层30和保护层26和28，都是器件包衣层74的部分。此外，图2的装饰层32的性质也可以是器件包衣层74的部分。
现参看图7，在根据本发明另一方面的另一实施例中，药丸76包括凸面，但可使用平面或凹面而不会限制本发明的范畴。标记78被紧固到药丸76上。封闭层80包围药丸76和标记78。在本实施例中，粘合剂层、保护层及装饰层(分别如图2的层30、层26/28和层32)的性质可以是封闭层80的部分。在本发明的替代方面，替代封闭层或除了封闭层80之外，标记78也可具有粘合性质。
现参看图8，在根据本发明另一方面的另一实施例中，示出了胶囊84。标记86被紧固到胶囊84的一端。层88包围标记86并且也被紧固到胶囊上。在本实施例中，粘合剂层、保护层及装饰层(分别如图2的层30、层26/28和层32)的性质可被并入层88中。在本发明的替代方面，替代层88或除了层88之外，标记86也可具有粘合性质。
现参看图9，在根据本发明另一方面的另一实施例中，示出了胶囊90。标记组件92被紧固到胶囊90的中间部分。标记组件92包围胶囊90的圆周。但是，根据本发明的另一方面，标记组件92可被设计成仅部分地包围胶囊90(未示出)。在本实施例中，粘合剂层、保护层及装饰层(分别如图2的层30、层26/28和层32)的性质可被并入标记组件92中。
现参看图10，其示出了将器件或器件组件紧固到药片或药丸上的方法步骤，所述方法步骤以步骤100开始，其中产生原芯药片或药丸。在步骤102中，将器件或器件组件附着到原芯药片上以产生经过装配的药片。在步骤104中，将包底衣添加到经过装配的药片上以产生包衣药片。在步骤106中，这是一个任选步骤，将彩色包衣添加到包衣药片上以产生彩色包衣片。在步骤108中，这是一个任选步骤，将彩色包衣片压印以产生用于分配的压印药片。
现参看图11，其示出了根据本发明另一方面将器件或器件组件紧固到药片或药丸上的方法步骤，所述步骤以步骤110开始，其中产生原芯药片或药丸。在步骤112中，将包底衣添加到原芯药片以产生包衣药片。在步骤114中，将器件或器件组件附着到包衣药片上以产生经过装配的包衣药片。在步骤116中，这是一个任选步骤，将彩色包衣添加到经过装配的包衣药片上以产生彩色包衣药片。在步骤118中，这是一个任选步骤，将彩色包衣药片压印以产生备用于分配的压印药片。
现参看图12，其示出了根据本发明的另一方面的将器件或器件组件紧固到药片或药丸上的方法步骤，所述步骤以步骤120开始，其中产生原芯药片或药丸。在步骤122中，将包底衣添加到原芯药片上以产生包衣药片。在步骤124中，将彩色包衣添加到包衣药片上以产生彩色包衣药片。在步骤126中，将器件或器件组件附着到彩色包衣药片上以产生经过装配的彩色包衣药片。在步骤128中，将第二包衣添加到经过装配的彩色包衣药片上以产生经过封闭装配的药片。在步骤129中，这是一个任选步骤，将经过封闭装配的药片压印以产生备用于分配的压印药片。
现参看图14、图15和图16，示出了压片机150。如所示，压片机150以逆时针方向旋转。压片机150包括模腔或冲压腔152和弹射托盘154。如所示，从位置A开始，药物制品存放在腔152内。压片机150旋转至位置B，该位置位于传送轮160下方。轮160包括数个开口162。当轮160经过位置C时，每个开口162都在馈料器170下方经过，如图16所示。
馈料器170含有标记器件200。器件200是IEM，其与导电流体接触时被激活。本发明的范畴不受环境或导电流体类型的限制。一旦被摄入，器件200就与导电流体(如胃液)接触，因而器件200被激活。再次参看器件200与被活生物体摄入的制品一起使用的情况，当包括器件200的制品被服用或摄入时，器件200就与身体的导电流体接触，并产生电压电势从而激活系统。电源的部分是由器件200提供，而电源的另一部分是由导电流体提供。
再次参看图14和图15，每次开口162在馈料器170下方经过时，器件200中的一个就会掉入直接在馈料器170下方的开口162中。如图15所示，所示的力“F”有助于器件200从馈料器170移动到开口162中。该力可通过吸入管168使用真空来提供。根据本发明的其它方面，除了重力之外，力可以由弹簧、气浪或推顶销来提供。轮160旋转到位置B。在位置B，位于开口162中的器件200掉入压片机150的腔152内。压片机150旋转到位置D，在此其它的药物制品被存放到器件200顶部的腔152内。压片机150继续在逆时针方向上移动并到达位置E，腔152的所容之物在高压下被压制以形成内部含有器件200的药片。通过弹射托盘154，所成药片被弹出并移动到收集处用于进一步的处理，如根据需要来涂覆层。
现参看图17，其示出作为替代实施方案并根据本发明的另一方面的馈料器组件172。馈料器组件172可用于代替图14的馈料器170。馈料器组件172包括将每个器件200保持到位的多个支撑指状物174。指状物174与皮带176连接。指状物174向着图14的轮160下移器件200。当指状物174到达靠近轮160的下方部位时，指状物174移开使得器件200掉入轮160的开口162中。
现参看图18A和图18B，根据本发明的另一方面，馈料器组件172包括带有弹簧175的弹射器173。随着开口162在馈料器组件172下方移动，弹射器173将器件200推入轮160的开口162内。
现参看图24A、图24B和图24C，其示出馈料器组件170a的替代实施例，该馈料器组件位于切割工具170b下方。网状片（web sheet）177位于馈料器组件170a与工具170b之间。网状片177将器件179递送到馈料器组件170a上方的位置。如图24B所示，工具170b向馈料器组件170a移动并切下器件179。弹射器170c向下移动以将器件179从工具170b中推出并推入馈料器组件170a中。如图24C所示，此过程继续并且器件179被馈入馈料器组件170a中。此方法可用于装载图16的馈料器170。根据本发明的另一方面，馈料器组件170a可用于替换图14和图16的馈料器170。
现参看图13，其示出将器件200装配到药片或药丸中的方法步骤，所述步骤以步骤130开始，其中粉末/原料被装入模具。在步骤132中，将器件200插入模具。在步骤134中，添加更多的粉末/原料并产生原芯药片或药丸。在步骤134中，将包衣层添加到原芯药片上以产生包衣药片。在步骤138中，将彩色包衣添加到包衣药片上以产生彩色包衣药片。在步骤139中，这是一个任选的步骤，将彩色包衣药片压印以产生备用于分配的压印药片。
根据本发明的另一方面，器件200可被紧固到制品的外部。将器件200装配或紧固到制品外部的方法可使用组件阵列来进行。现参看图19和图20，其示出了包括定位槽182的轮180。图20中更详细地示出槽182。每个槽182中都具有开口184。穿过开口184产生真空，当药丸186从料斗盘188被递送到轮180时，所述真空将药丸186吸拉到位。根据本发明的其它方面，药丸186可通过不同于真空吸拉的其它方法来定位。药丸186可被振动到位或用某些形式的扫刮器进行刷扫，因此药丸会落入开口中并且多余药丸会被刷去。当轮180旋转时，药丸186移动到施加粘合剂层的站区1。当轮180移动到站区2时，器件200被紧固在每个药丸186上。当轮180移动到站区3时，施加保护层。当轮180移动到站区4时，施加装饰层或印刷层。其后，完整并经过印刷的药片或药丸186从轮180移送到中央收集处以作进一步处理或分配。本发明的范畴不受轮180上站区数目的限制。例如，轮180可被设计成具有一个站区，在这个站区上，将预先装配的器件施加到药丸186上。预先装配的器件可以与带有粘合剂层的IEM或与上文就图1所讨论的一样简单。
现参看图21，在图19中示出的每个站区，进行各种装配步骤，包括在药片上安装器件以及其它元件或部件。所示出的递送臂230的部分位于药丸186的部分的上方。递送臂230在轮180与网状物232之间移动。网状物232含有按顺序排列的器件234，以便允许递送臂230拾取器件234。递送臂230从网状物232移去器件234并将器件234紧固到药丸186上。根据本发明的另一方面，将器件234从网状物232切下或冲压取出。在其它的站区，其它递送臂从不同的网状辊上移去或冲压取下或切下其它材料并将那些材料紧固到药丸186上。例如，递送臂可从网状片上移去保护层并将其紧固在已紧固有器件的药片上。根据本发明的另一方面，位于网状物上的器件可以是标记组件单元以使得单次安装过程就是所需的全部，并且每个站区都可用于使用递送臂230来执行将标记组件从网状物移动到药丸186的单次任务。
现参看图22，其示出装配过程，其中工具210包括腔212。在将器件形成到药丸或药片216上之前，将工具210置于包括电路元件214a的装配器件214上方。使工具210形成为药片216的形状和下降至器件214上。通过施加温度和压力，将器件214改造成器件218和将其紧固在药片216上成为器件220。腔212阻止压力施加于器件214的电路元件214a上。
现参看图23A、图23B和图23C，根据本发明的另一方面，其示出了替代装配过程，其中压制工具或切割工具240位于压台242上方。压台242包括具有中央孔248的槽246。使用穿过孔248施加的真空吸力将药片250保持在槽246中。网状片252位于压台242与工具240之间。网状片252包括器件254。为开始装配过程，工具240向压台242移动。如图23B所示，网状片252被冲压并且器件254被紧固到药片250上。在装配过程中的不同站区或位置处，包括不同层的板片256在装配过程中位于压台242与切割工具260之间，所述压台当下保持有紧固了器件254的药片250。切割工具260向压台242移动并且将层256紧固到药片250上(未示出)以形成装配有器件254的包衣药片250。
现参看图25，其示出根据本发明的另一方面的装配过程。装配单元300包括压机302和压机304。压机302位于网状物308上方。网状物308具有定位并保持在网状物308的适当位置上的器件306。器件306具有将其保持在网状物308上的粘合剂层和位于相反侧邻近药片312的第二粘合剂层。随着网状物308从辊310a移动至辊310b，器件被提供并置于药片312上方，药片则位于药片馈料器皮带314上。当器件306向压机302移动时，馈料器皮带314将药片312向压机304移动。当药片312接近压机304时，每个药片312都落入压机304的槽304a内。然后，当压机302将器件306推向压机304时，药片312被压机304抬高送至压机302。在位置318处，器件306被压在药片312上并被紧固在药片上。当压机302和压机304旋转时，网状物308向辊310b移动。同时，经过装配的药片320被下降至取走辊皮带322上，其将经过装配的药片320从压机302和压机304移走。经过装配的药片320可被移至该方法的下一阶段，包括包装以供分配或其它制备步骤，如添加其它的层或包衣。
受关注的实施方案包括高产量制造过程，例如，关于这些实施方案的细节提供在上文和/或美国临时申请第61/142,849号中；所述申请的公开内容以引用的方式并入本文。
如本文所述，本发明的系统是与导电流体一起使用以指明由导电流体与系统之间接触所标记的事件。举例来说，本公开的系统可与药物制品一起使用并且所指明的事件就是制品何时被服用或摄入。术语“被摄入”或“摄入”或“正在摄入”应理解为指系统到体内的任何引入。举例来说，正在摄入包括单纯地将系统放入嘴中直到到达降结肠。因此，术语正在摄入是指当系统被引入含有导电流体的环境中的任何时刻。另一个实施例是不导电流体与导电流体相混合的情形。在这样的情形下，系统将存在于在不导电流体中并且当两种流体混合时，系统就与导电流体接触从而激活系统。另一实施例将是存在需要被检测的某些导电流体时的情形。在这些实施例中，可检测导电流体中将被激活的系统的存在，并因此检测到各种流体的存在。
应当注意，除非文章另外明确指出，否则本文和所附权利要求书中使用的单数形式“一个(种)”和“所述”都包括对复数的提及。应当进一步注意，所撰写的权利要求书可排除任何任选的要件。同样，希望本陈述作为以下的前提基础：与权利要求书要件的叙述联合使用如“单独的”、“唯一的”等的这类排他术语，或使用“否定”限定。
本领域的技术人员在阅读本公开后将明白：本文描述和说明的每个单独的实施方案都有分立元件和特征，可容易将其与其它若干实施方案中任何实施方案的特征分开或进行组合，而不会脱离本发明的范畴或精神。任何叙述的方法都可以所叙述的事件顺序或以逻辑上可能的任何其它顺序来实施。
虽然本发明已通过举例说明的方式在一定程度上进行了详细描述以达理解清楚的目的，但是根据本发明的教导，对本领域的普通技术人员来说显而易见的是：可对本发明做出某些变化和修改，而不会脱离本发明的精神或范畴。
因此，前文仅仅说明本发明的原则。应了解，本领域的技术人员能够设计出体现本发明的原则和包括在本发明精神和范畴内的各种配置，尽管所述配置在本文没有明确描述或示出。此外，主要希望本文叙述的所有实施例和条件性语言是帮助读者理解本发明的原则和发明者为推动技术进步而提供的概念，并且应被解释为不限于这些具体陈述的实施例和条件。另外，希望本文中叙述本发明原则、方面和实施方案以及其特定实施例的所有陈述涵盖其结构上和功能上的等价方案。此外，希望这些等价方案包括目前已知的等价方案和未来研发的等价方案，即，在不考虑结构情况下，所研发的执行相同的功能的任何要件。因此，希望本发明的范畴不限于本文示出和描述的示例性实施方案。相反，本发明的范畴和精神是由所附权利要求书体现。

Claims (21)

1.一种药物制品，包括：
药丸；以及
器件，所述器件包括顶部和底部，并且被紧固到所述药丸上，
其特征在于，所述器件包括：
界定出中央腔的不导电裙缘；
位于由所述裙缘界定的所述腔内的控制单元，其中所述控制单元包括至少两种不同类材料，所述不同材料位于所述控制单元的相对侧上并且与所述控制单元电连接，其中当所述不同类材料暴露于导电流体时，产生向所述控制单元供电的电压电势，并且其中当所述控制单元被供电时，产生电流信号，所述电流信号中编码有信息；和
所述器件底部上的紧固部分，其用于将所述器件紧固到所述药丸。
2.根据权利要求1所述的药物制品，其特征在于，所述药物制品还包括位于所述器件顶部的保护层。
3.根据权利要求2所述的药物制品，其特征在于，所述保护层与所述裙缘的尺寸相同并且覆盖所述控制单元的顶部。
4.根据权利要求2所述的药物制品，其特征在于，所述保护层相对于所述器件尺寸大，使得所述保护层可紧固到所述药丸的表面来密封所述器件以与周围环境隔绝。
5.根据权利要求2所述的药物制品，其特征在于，所述紧固部分是位于所述裙缘上所述器件的底部上的多个粘合剂点。
6.根据权利要求5所述的药物制品，其特征在于，所述紧固部分与所述器件的尺寸相同并且覆盖所述器件的底部。
7.根据权利要求2所述的药物制品，其特征在于，所述药物制品还包括位于所述器件的底部上并在所述器件和所述紧固部分之间的第二保护层。
8.根据权利要求7所述的药物制品，其特征在于，所述第二保护层与所述裙缘的尺寸相同并覆盖控制单元的底部。
9.根据权利要求7所述的药物制品，其特征在于，所述紧固部分是位于所述第二保护层上并围绕所述器件的多个粘合剂点。
10.根据权利要求7所述的药物制品，其特征在于，所述紧固部分与所述器件的尺寸相同并位于所述第二保护层上。
11.根据权利要求7所述的药物制品，其特征在于，所述裙缘界定多个孔以使得所述保护层和所述第二保护层经由所述孔连接在一起。
12.一种带有电子标记的药片，所述药片包括：
含有药物的第一药片部分；和
含有速溶剂的第二药片部分，其中所述速溶剂和药物是化学相容的，其中所述第一药片部分和第二药片部分界定出用于保持所述电子标记的腔，
其特征在于，所述电子标记包括：
界定出中央腔的不导电裙缘；
位于由所述裙缘界定的所述腔内的控制单元，其中所述控制单元包括定位为由所述裙缘隔开的至少两种不同类材料，所述不同类材料形成电源的一部分并代表电压电势，并且产生电流信号，所述电流信号中编码有信息；
界定包围所述裙缘和控制单元的袋状物的包衣，其中所述包衣溶解掉以将所述控制单元暴露于周围环境。
13.根据权利要求12所述的药片，其特征在于，所述药片置于胶囊内部。
14.根据权利要求12所述的药片，其特征在于，所述胶囊填充有第二药物。
15.一种用于制造带有电流控制器件的药物制品的方法，所述方法包括：
制造药丸；
用粘合剂部分将所述电流控制器件紧固到所述药丸上以制得经过标记的药丸；和
使用置于所述经过标记的药丸上的所述控制器件顶部的保护层来保护所述经过标记的药丸，以形成所述药物制品。
16.根据权利要求15所述的方法，其特征在于，还包括将所述保护层切割成与所述电流控制器件尺寸相同的步骤。
17.根据权利要求16所述的方法，其特征在于，还包括将所述保护层切割成相对于所述电流控制器件来说尺寸大的步骤，以便所述保护层能紧固到所述药丸的表面来密封所述电流控制器件而与周围环境隔绝。
18.根据权利要求15所述的方法，其特征在于，所述紧固步骤包括使用多个粘合剂点作为所述粘合剂部分并将所述点定位于所述电流控制器件的底部上。
19.根据权利要求15所述的方法，其特征在于，所述紧固步骤包括使用粘合剂片作为所述粘合剂部分并使所述粘合剂片与所述电流控制器件的尺寸相同。
20.一种用于制造含有层合器件的可鉴别药片的方法，所述方法包括：
将原粉的第一部分装入由压机轮界定的腔内，其中所述原粉的第一部分是药物；
压制所述原粉的第一部分以形成第一药片部分；
将所述器件插入含有所述第一药片部分的腔内；
将原粉的第二部分装入所述腔内形成第二药片部分；和
压制所述腔的所容之物以形成所述第一药片部分与所述第二药片部分的密封，从而形成所述可鉴别药片。
21.一种药物制品，包括：
药丸；和
器件，所述器件包括顶部和底部，
其特征在于，使用位于所述器件底部用于将所述器件紧固到所述药丸上的紧固部分和位于所述器件顶部用于保护所述器件免受环境影响的保护层将所述器件紧固到所述药丸上。
CN2013103150557A 2009-12-02 2010-12-02 与药物制品整合的可摄入的事件标记系统 Pending CN103405341A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26610309P 2009-12-02 2009-12-02
US61/266,103 2009-12-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2010800622847A Division CN102724948A (zh) 2009-12-02 2010-12-02 与药物制品整合的可摄入的事件标记系统

Publications (1)

Publication Number Publication Date
CN103405341A true CN103405341A (zh) 2013-11-27

Family

ID=44115496

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201410494980.5A Active CN104323917B (zh) 2009-12-02 2010-12-02 与药物制品整合的可摄入的事件标记系统
CN2013103150557A Pending CN103405341A (zh) 2009-12-02 2010-12-02 与药物制品整合的可摄入的事件标记系统
CN2010800622847A Pending CN102724948A (zh) 2009-12-02 2010-12-02 与药物制品整合的可摄入的事件标记系统

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201410494980.5A Active CN104323917B (zh) 2009-12-02 2010-12-02 与药物制品整合的可摄入的事件标记系统

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2010800622847A Pending CN102724948A (zh) 2009-12-02 2010-12-02 与药物制品整合的可摄入的事件标记系统

Country Status (19)

Country Link
US (3) US8784308B2 (zh)
EP (2) EP2774595B1 (zh)
JP (5) JP2013512737A (zh)
KR (1) KR101771532B1 (zh)
CN (3) CN104323917B (zh)
AU (1) AU2010326002B2 (zh)
BR (1) BR112012013504A2 (zh)
CA (1) CA2782683A1 (zh)
DK (2) DK2506820T3 (zh)
ES (2) ES2533801T3 (zh)
HK (2) HK1176854A1 (zh)
IL (1) IL220126A (zh)
MX (1) MX2012006414A (zh)
MY (1) MY156819A (zh)
SG (1) SG181489A1 (zh)
TW (1) TWI532478B (zh)
UA (1) UA109424C2 (zh)
WO (1) WO2011068963A2 (zh)
ZA (2) ZA201204128B (zh)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
KR101568660B1 (ko) 2006-05-02 2015-11-12 프로테우스 디지털 헬스, 인코포레이티드 환자 주문형 치료법
MY158019A (en) 2006-10-25 2016-08-30 Proteus Digital Health Inc Controlled activation ingestible identifier
US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
JP5524626B2 (ja) 2007-02-01 2014-06-18 プロテウス デジタル ヘルス， インコーポレイテッド 摂取可能な事象マーカシステム
CN103066226B (zh) 2007-02-14 2016-09-14 普罗透斯数字保健公司 具有高表面积电极的体内电源
US8932221B2 (en) 2007-03-09 2015-01-13 Proteus Digital Health, Inc. In-body device having a multi-directional transmitter
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
US8115618B2 (en) 2007-05-24 2012-02-14 Proteus Biomedical, Inc. RFID antenna for in-body device
FI2192946T3 (fi) 2007-09-25 2022-11-30 Elimistön sisäinen laite, jossa on virtuaalinen dipolisignaalinvahvistus
WO2009070773A1 (en) 2007-11-27 2009-06-04 Proteus Biomedical, Inc. Transbody communication systems employing communication channels
CN104376659B (zh) 2008-03-05 2019-10-25 普罗透斯数字保健公司 多模式通信可摄取事件标记和系统，及使用其的方法
ES2696984T3 (es) 2008-07-08 2019-01-21 Proteus Digital Health Inc Infraestructura de datos de marcadores de eventos de ingestión
CN104382598A (zh) 2008-08-13 2015-03-04 普罗透斯数字保健公司 一种产生识别器的方法
CN102341031A (zh) 2009-01-06 2012-02-01 普罗秋斯生物医学公司 摄取相关的生物反馈和个人化医学治疗方法和系统
WO2010111403A2 (en) 2009-03-25 2010-09-30 Proteus Biomedical, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
NZ619375A (en) 2009-04-28 2015-03-27 Proteus Digital Health Inc Highly reliable ingestible event markers and methods for using the same
WO2010132331A2 (en) 2009-05-12 2010-11-18 Proteus Biomedical, Inc. Ingestible event markers comprising an ingestible component
TWI517050B (zh) 2009-11-04 2016-01-11 普羅托斯數位健康公司 供應鏈管理之系統
UA109424C2 (uk) * 2009-12-02 2015-08-25 Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки
RU2012143791A (ru) 2010-04-07 2014-05-20 Проутьюс Диджитал Хэлс, Инк. Миниатюрное проглатываемое устройство
TWI557672B (zh) 2010-05-19 2016-11-11 波提亞斯數位康健公司 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置
JP2014504902A (ja) 2010-11-22 2014-02-27 プロテウス デジタル ヘルス， インコーポレイテッド 医薬品を有する摂取可能なデバイス
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
IN2014MN00183A (zh) 2011-07-21 2015-06-19 Proteus Digital Health Inc
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
US20130129869A1 (en) * 2011-11-23 2013-05-23 Hooman Hafezi Compositions comprising a shelf-life stability component
KR20150038038A (ko) 2012-07-23 2015-04-08 프로테우스 디지털 헬스, 인코포레이티드 섭취 가능한 부품을 포함하는 섭취 가능한 이벤트 마커를 제조하기 위한 기술
DK2910013T3 (en) 2012-10-18 2018-08-06 Proteus Digital Health Inc Apparatus, system and method for adaptive optimization for power output and transmit power in a power source for a communication device
TWI590818B (zh) * 2012-12-19 2017-07-11 Otsuka Pharma Co Ltd Medicine tablet, its manufacturing method and its manufacturing device
JP6276018B2 (ja) * 2012-12-19 2018-02-07 大塚製薬株式会社 医薬用錠剤、その製造方法およびその製造装置
WO2014120669A1 (en) 2013-01-29 2014-08-07 Proteus Digital Health, Inc. Highly-swellable polymeric films and compositions comprising the same
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
JP6511439B2 (ja) 2013-06-04 2019-05-15 プロテウス デジタル ヘルス， インコーポレイテッド データ収集および転帰の査定のためのシステム、装置、および方法
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
JP2019515032A (ja) * 2016-04-25 2019-06-06 大塚製薬株式会社 摂取型イベントマーカーを有する医薬品の組成物
WO2017223043A1 (en) * 2016-06-22 2017-12-28 University Of Florida Research Foundation, Inc. Pharmaceutical capsules for medication adherence monitoring and methods of forming the same
BR112019000861B1 (pt) * 2016-07-22 2020-10-27 Proteus Digital Health, Inc dispositivo eletrônico
TWI735689B (zh) * 2016-10-26 2021-08-11 日商大塚製藥股份有限公司 製造含有可攝食性事件標記之膠囊之方法
WO2018200691A2 (en) 2017-04-25 2018-11-01 Proteus Digital Health, Inc. Lisinopril compositions with an ingestible event marker

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1650844A (zh) * 1999-08-05 2005-08-10 美商戴冕勋食品公司 可食性全息照相产品,具体药剂及其产生方法与装置
US20060028727A1 (en) * 2002-08-20 2006-02-09 Moon John A Method and apparatus for drug product tracking using encoded optical identification elements
US20060210626A1 (en) * 2005-03-17 2006-09-21 Spaeder Jeffrey A Radio frequency identification pharmaceutical tracking system and method
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging

Family Cites Families (648)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2973555A (en) * 1955-09-09 1961-03-07 Agustin Mesa Rotary press for fabrication of buttons and plastic articles
US3048526A (en) * 1958-08-04 1962-08-07 Wander Company Medicinal tablet
US3096248A (en) * 1959-04-06 1963-07-02 Rexall Drug & Chemical Company Method of making an encapsulated tablet
US3079824A (en) * 1960-08-09 1963-03-05 Houdaille Industries Inc Punching device having a spring biased stripper
US3176399A (en) * 1962-09-20 1965-04-06 Anthony J Marino Tool punch with spring actuated impact means
US3799802A (en) 1966-06-28 1974-03-26 F Schneble Plated through hole printed circuit boards
US3607788A (en) 1967-11-20 1971-09-21 Robert J Adolph Liquid electrode material
US3589943A (en) 1968-08-29 1971-06-29 Gen Electric Electrochemical battery
US3642008A (en) 1968-09-25 1972-02-15 Medical Plastics Inc Ground electrode and test circuit
US3679480A (en) 1969-05-08 1972-07-25 Dow Chemical Co Electrical cell assembly
US3682160A (en) 1969-10-16 1972-08-08 Matsushita Electric Ind Co Ltd Physiological signal transmitter for use inside the body
US3719183A (en) 1970-03-05 1973-03-06 H Schwartz Method for detecting blockage or insufficiency of pancreatic exocrine function
US3837339A (en) 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3828766A (en) 1972-08-14 1974-08-13 Jet Medical Prod Inc Disposable medical electrode
US3989050A (en) 1972-09-19 1976-11-02 Gilbert Buchalter Process for utilizing certain gel compositions for electrical stimulation
US3944064A (en) 1973-10-26 1976-03-16 Alza Corporation Self-monitored device for releasing agent at functional rate
US4106348A (en) 1974-02-20 1978-08-15 U.S. Philips Corporation Device for examination by means of ultrasonic vibrations
US3893111A (en) 1974-03-14 1975-07-01 Albert Albert F System and method for remote monitoring of animal temperature
US3967202A (en) 1974-07-25 1976-06-29 Northern Illinois Gas Company Data transmission system including an RF transponder for generating a broad spectrum of intelligence bearing sidebands
US4090752A (en) 1974-10-07 1978-05-23 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
ZA755785B (en) 1974-10-07 1976-08-25 Baxter Laboratories Inc Diagnostic electrode assembly
US4077397A (en) 1974-10-07 1978-03-07 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
US4139589A (en) * 1975-02-26 1979-02-13 Monique Beringer Process for the manufacture of a multi-zone tablet and tablet manufactured by this process
US4055178A (en) 1976-03-10 1977-10-25 Harrigan Roy Major Drug delivery device for preventing contact of undissolved drug with the stomach lining
US4017856A (en) 1976-03-10 1977-04-12 Westinghouse Electric Corporation Self-calibrating microwave transponder
US4062752A (en) 1976-10-04 1977-12-13 Myron Lester Peterson Plating mechanism
US4129125A (en) 1976-12-27 1978-12-12 Camin Research Corp. Patient monitoring system
GB1594214A (en) 1977-01-21 1981-07-30 Cardio Tech Body electrodes
US4082087A (en) 1977-02-07 1978-04-04 Isis Medical Instruments Body contact electrode structure for deriving electrical signals due to physiological activity
JPS5475284A (en) 1977-11-29 1979-06-15 Asahi Chemical Ind Threeeterminal magnetic reluctance effect element
US4239046A (en) 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4345588A (en) 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4269189A (en) 1979-07-09 1981-05-26 Consolidated Medical Equipment Inc. Skin conducting electrode assembly
DE2928477C3 (de) 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
US4331654A (en) 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4418697A (en) 1981-08-17 1983-12-06 Francine Tama Electrode attachment method
US4494950A (en) 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4564363A (en) 1983-07-13 1986-01-14 Smithkline Beckman Corporation Delayed action assembly
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4559950A (en) 1983-11-25 1985-12-24 Graphic Controls Corporation Disposable biomedical and diagnostic electrode
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4654165A (en) 1985-04-16 1987-03-31 Micro Tracers, Inc. Microingredient containing tracer
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4763659A (en) 1985-08-21 1988-08-16 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4669479A (en) 1985-08-21 1987-06-02 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4635641A (en) 1985-10-16 1987-01-13 Murray Electronics Associates Limited Multi-element electrode
US4775536A (en) * 1986-02-24 1988-10-04 Bristol-Myers Company Enteric coated tablet and process for making
US4663250A (en) 1986-03-12 1987-05-05 Institute Of Gas Technology Reduction of electrode dissolution
US4725997A (en) 1986-08-22 1988-02-16 Aprex Corporation Contingent dosing device
US4784162A (en) 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
US4847090A (en) * 1986-11-07 1989-07-11 Warner-Lambert Company Confection product and method for making same
US4896261A (en) 1986-11-24 1990-01-23 Motorola Inc. System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages using a doubly-linked list
US4876093A (en) 1987-07-02 1989-10-24 Alza Corporation Dispenser with dispersing member for delivering beneficial agent
DE3723310A1 (de) 1987-07-15 1989-01-26 John Urquhart Pharmazeutisches praeparat und verfahren zu seiner herstellung
US4814181A (en) * 1987-09-03 1989-03-21 Alza Corporation Dosage form comprising fast agent delivery followed by slow agent delivery
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
CA1327838C (fr) 1988-06-13 1994-03-15 Fred Zacouto Dispositif implantable de protection contre les affections liees a la coagulation sanguine
US4975230A (en) 1988-06-17 1990-12-04 Vapor Technologies Inc. Method of making an open pore structure
US4844076A (en) 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
EP0392032B1 (de) 1989-04-10 1995-01-25 Pacesetter AB Implantierbares medizinisches Gerät mit Mitteln zum telemetrischen Übertragen von Daten
CA2016517C (en) 1989-05-11 1999-01-12 Dale R. Shackle Solid state electrochemical cell having microroughened current collector
US5281287A (en) 1989-07-21 1994-01-25 Iomed, Inc. Method of making a hydratable bioelectrode
US4987897A (en) 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US5213738A (en) * 1990-05-15 1993-05-25 L. Perrigo Company Method for making a capsule-shaped tablet
US6749122B1 (en) 1990-05-25 2004-06-15 Broadcom Corporation Multi-level hierarchial radio-frequency system communication system
US6359872B1 (en) 1997-10-28 2002-03-19 Intermec Ip Corp. Wireless personal local area network
US5167626A (en) 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5395366A (en) 1991-05-30 1995-03-07 The State University Of New York Sampling capsule and process
US5176626A (en) 1992-01-15 1993-01-05 Wilson-Cook Medical, Inc. Indwelling stent
ATE197761T1 (de) 1992-04-03 2000-12-15 Micromedical Ind Ltd Anordnung zur überwachung physiologischer parameter
US5263481A (en) 1992-05-21 1993-11-23 Jens Axelgaard Electrode system with disposable gel
US5283136A (en) 1992-06-03 1994-02-01 Ramot University Authority For Applied Research And Industrial Development Ltd. Rechargeable batteries
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5261402A (en) 1992-07-20 1993-11-16 Graphic Controls Corporation Snapless, tabless, disposable medical electrode with low profile
US5338625A (en) 1992-07-29 1994-08-16 Martin Marietta Energy Systems, Inc. Thin film battery and method for making same
US7758503B2 (en) 1997-01-27 2010-07-20 Lynn Lawrence A Microprocessor system for the analysis of physiologic and financial datasets
US5757326A (en) 1993-03-29 1998-05-26 Seiko Epson Corporation Slot antenna device and wireless apparatus employing the antenna device
US5394882A (en) 1993-07-21 1995-03-07 Respironics, Inc. Physiological monitoring system
US5458141A (en) 1993-08-04 1995-10-17 Quinton Instrument Company Abrasive skin electrode
US5443461A (en) 1993-08-31 1995-08-22 Alza Corporation Segmented device for simultaneous delivery of multiple beneficial agents
DE4329898A1 (de) 1993-09-04 1995-04-06 Marcus Dr Besson Kabelloses medizinisches Diagnose- und Überwachungsgerät
EP0841965B1 (en) 1994-03-21 2002-04-10 Dusa Pharmaceuticals, Inc. Patch and controller for the photodynamic therapy of a dermal lesion
US5600548A (en) 1994-08-11 1997-02-04 Sundstrand Corporation DC content control for an inverter
IE70735B1 (en) 1994-08-15 1996-12-11 Elan Med Tech Orally administrable delivery device
DE9414065U1 (de) 1994-08-31 1994-11-03 Roehm Gmbh Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen
IL111396A (en) 1994-10-25 1997-07-13 Ness Neuromuscular Electrical Stimulation Systems Ltd Electrode system
US5485841A (en) 1995-02-14 1996-01-23 Univ Mcgill Ultrasonic lung tissue assessment
US5778882A (en) 1995-02-24 1998-07-14 Brigham And Women's Hospital Health monitoring system
US6374670B1 (en) 1995-03-13 2002-04-23 University Of Washington Non-invasive gut motility monitor
US5845265A (en) 1995-04-26 1998-12-01 Mercexchange, L.L.C. Consignment nodes
US5645063A (en) 1995-06-05 1997-07-08 Quinton Instrument Company Skin electrode having multiple conductive center members
US5738708A (en) 1995-06-07 1998-04-14 The Regents Of The University Of California Office Of Technology Transfer Composite metal membrane
US5802467A (en) 1995-09-28 1998-09-01 Innovative Intelcom Industries Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception
US6076016A (en) 1995-10-19 2000-06-13 Feierbach; Gary F. Galvanic transdermal conduction communication system and method
GB9522872D0 (en) 1995-11-08 1996-01-10 Oxford Medical Ltd Improvements relating to physiological monitoring
US8092224B2 (en) 1995-11-22 2012-01-10 James A. Jorasch Systems and methods for improved health care compliance
SE9504258D0 (sv) 1995-11-28 1995-11-28 Pacesetter Ab Device and method for generating a synthesized ECG
US5596302A (en) 1996-01-17 1997-01-21 Lucent Technologies Inc. Ring oscillator using even numbers of differential stages with current mirrors
US5868136A (en) 1996-02-20 1999-02-09 Axelgaard Manufacturing Co. Ltd. Medical electrode
US20010044588A1 (en) 1996-02-22 2001-11-22 Mault James R. Monitoring system
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
UA48221C2 (uk) 1996-04-01 2002-08-15 Валєрій Івановіч Кобозєв Електростимулятор шлунково-кишкового тракту
US5864578A (en) 1996-04-29 1999-01-26 Golden Bridge Technology, Inc. Matched filter-based handoff method and apparatus
US5800421A (en) 1996-06-12 1998-09-01 Lemelson; Jerome H. Medical devices using electrosensitive gels
JP2000516504A (ja) 1996-08-16 2000-12-12 ロシュ ダイアグノスティックス ゲーエムベーハー 薬剤の規則的摂取の監視システム
US5792048A (en) 1996-09-03 1998-08-11 Schaefer; Guenter Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners
US5963132A (en) * 1996-10-11 1999-10-05 Avid Indentification Systems, Inc. Encapsulated implantable transponder
US6364834B1 (en) 1996-11-13 2002-04-02 Criticare Systems, Inc. Method and system for remotely monitoring multiple medical parameters in an integrated medical monitoring system
US8734339B2 (en) 1996-12-16 2014-05-27 Ip Holdings, Inc. Electronic skin patch for real time monitoring of cardiac activity and personal health management
US5974124A (en) 1997-01-21 1999-10-26 Med Graph Method and system aiding medical diagnosis and treatment
US6122351A (en) 1997-01-21 2000-09-19 Med Graph, Inc. Method and system aiding medical diagnosis and treatment
US6047203A (en) 1997-03-17 2000-04-04 Nims, Inc. Physiologic signs feedback system
US5981166A (en) 1997-04-23 1999-11-09 Pharmaseq, Inc. Screening of soluble chemical compounds for their pharmacological properties utilizing transponders
DE19717023C2 (de) 1997-04-23 2003-02-06 Micronas Gmbh Vorrichtung zum Behandeln von malignen, tumorösen Gewebebereichen
US6288629B1 (en) 1997-05-23 2001-09-11 Intermec Ip Corp. Method of using write—ok flag for radio frequency (RF) transponders (RF Tags)
US5984875A (en) 1997-08-22 1999-11-16 Innotek Pet Products, Inc. Ingestible animal temperature sensor
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US6097927A (en) 1998-01-27 2000-08-01 Symbix, Incorporated Active symbolic self design method and apparatus
US6038464A (en) 1998-02-09 2000-03-14 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7542878B2 (en) 1998-03-03 2009-06-02 Card Guard Scientific Survival Ltd. Personal health monitor and a method for health monitoring
US6141592A (en) 1998-03-06 2000-10-31 Intermedics Inc. Data transmission using a varying electric field
US6579231B1 (en) 1998-03-27 2003-06-17 Mci Communications Corporation Personal medical monitoring unit and system
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
WO1999058051A1 (en) 1998-05-13 1999-11-18 Cygnus, Inc. Monitoring of physiological analytes
US6477424B1 (en) 1998-06-19 2002-11-05 Medtronic, Inc. Medical management system integrated programming apparatus for communication with an implantable medical device
US6704602B2 (en) 1998-07-02 2004-03-09 Medtronic, Inc. Implanted medical device/external medical instrument communication utilizing surface electrodes
US7548787B2 (en) 2005-08-03 2009-06-16 Kamilo Feher Medical diagnostic and communication system
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6333699B1 (en) 1998-08-28 2001-12-25 Marathon Oil Company Method and apparatus for determining position in a pipe
BR9913610A (pt) 1998-09-04 2001-10-09 Wolfe Res Pty Ltd Sistema de implante médico
FI116957B (fi) 1998-10-29 2006-04-13 Nokia Corp Menetelmä langattoman laitteen ja elektroniikkalaitteen välistä tiedonsiirtoa varten ja tiedonsiirtolaite
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6547994B1 (en) * 1998-11-13 2003-04-15 Therics, Inc. Rapid prototyping and manufacturing process
US6217744B1 (en) 1998-12-18 2001-04-17 Peter Crosby Devices for testing fluid
ATE244022T1 (de) 1998-12-21 2003-07-15 Sequella Inc Verwendungsmethoden und zusammenstellungen enthaltend überwachungsystem
US6115636A (en) 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6269058B1 (en) 1999-01-04 2001-07-31 Texas Instruments Incorporated Wide capture range circuitry
US6358202B1 (en) 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6285897B1 (en) 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6755783B2 (en) 1999-04-16 2004-06-29 Cardiocom Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients
US6290646B1 (en) 1999-04-16 2001-09-18 Cardiocom Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients
ATE256421T1 (de) 1999-05-25 2004-01-15 Medicotest As Hautelektrode
EP1194903B1 (en) 1999-05-26 2013-11-13 Johnson Controls Technology Company Wireless communications system and method
US6366206B1 (en) 1999-06-02 2002-04-02 Ball Semiconductor, Inc. Method and apparatus for attaching tags to medical and non-medical devices
EP1060704A3 (en) 1999-06-18 2002-09-18 Agilent Technologies, Inc. (a Delaware corporation) Multi-parameter capability transmitter for wireless telemetry systems
JP3402267B2 (ja) 1999-06-23 2003-05-06 ソニーケミカル株式会社 電子素子の実装方法
DE19929328A1 (de) 1999-06-26 2001-01-04 Daimlerchrysler Aerospace Ag Vorrichtung zur medizinischen Langzeitüberwachung von Personen
US6287252B1 (en) 1999-06-30 2001-09-11 Monitrak Patient monitor
US6307468B1 (en) 1999-07-20 2001-10-23 Avid Identification Systems, Inc. Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6206702B1 (en) 1999-08-24 2001-03-27 Deborah A. Hayden Methods and devices for treating unilateral neglect
US6526034B1 (en) 1999-09-21 2003-02-25 Tantivy Communications, Inc. Dual mode subscriber unit for short range, high rate and long range, lower rate data communications
US6533733B1 (en) 1999-09-24 2003-03-18 Ut-Battelle, Llc Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring
US6990082B1 (en) 1999-11-08 2006-01-24 Intel Corporation Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols
WO2001026232A2 (en) 1999-10-07 2001-04-12 La Mont, Llc Physiological signal monitoring apparatus and method
US6852084B1 (en) 2000-04-28 2005-02-08 Peter V. Boesen Wireless physiological pressure sensor and transmitter with capability of short range radio frequency transmissions
US6426863B1 (en) 1999-11-25 2002-07-30 Lithium Power Technologies, Inc. Electrochemical capacitor
US6612984B1 (en) 1999-12-03 2003-09-02 Kerr, Ii Robert A. System and method for collecting and transmitting medical data
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US6294999B1 (en) 1999-12-29 2001-09-25 Becton, Dickinson And Company Systems and methods for monitoring patient compliance with medication regimens
US8002700B2 (en) 1999-12-30 2011-08-23 Medtronic, Inc. Communications system for an implantable medical device and a delivery device
DE60030086T2 (de) 2000-01-20 2007-01-04 Lucent Technologies Inc. Interoperabilität von Bluetooth und IEEE 802.11
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
KR100798048B1 (ko) 2000-03-08 2008-01-24 기븐 이미징 리미티드 체내 촬상용 캡슐
US6526315B1 (en) 2000-03-17 2003-02-25 Tanita Corporation Portable bioelectrical impedance measuring instrument
DE10014588A1 (de) 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
US6622050B2 (en) 2000-03-31 2003-09-16 Medtronic, Inc. Variable encryption scheme for data transfer between medical devices and related data management systems
US6757523B2 (en) 2000-03-31 2004-06-29 Zeus Wireless, Inc. Configuration of transmit/receive switching in a transceiver
US6922592B2 (en) 2000-04-04 2005-07-26 Medtronic, Inc. Implantable medical device controlled by a non-invasive physiological data measurement device
US6654638B1 (en) 2000-04-06 2003-11-25 Cardiac Pacemakers, Inc. Ultrasonically activated electrodes
US6441747B1 (en) 2000-04-18 2002-08-27 Motorola, Inc. Wireless system protocol for telemetry monitoring
US6496705B1 (en) 2000-04-18 2002-12-17 Motorola Inc. Programmable wireless electrode system for medical monitoring
US6836862B1 (en) 2000-04-24 2004-12-28 3Com Corporation Method of indicating wireless connection integrity
US6792247B2 (en) 2000-05-08 2004-09-14 Microtune (San Diego), Inc. Co-located frequency-agile system and method
US6432292B1 (en) 2000-05-16 2002-08-13 Metallic Power, Inc. Method of electrodepositing metal on electrically conducting particles
EP1404213B1 (en) 2000-05-19 2011-03-23 Welch Allyn Protocol Inc Patient monitoring system
US6680923B1 (en) 2000-05-23 2004-01-20 Calypso Wireless, Inc. Communication system and method
EP1284644B1 (en) 2000-05-29 2004-10-20 Medicotest A/S An electrode for establishing electrical contact with the skin
IL163684A0 (en) 2000-05-31 2005-12-18 Given Imaging Ltd Measurement of electrical characteristics of tissue
GB0014854D0 (en) 2000-06-16 2000-08-09 Isis Innovation System and method for acquiring data
US20060122474A1 (en) 2000-06-16 2006-06-08 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
GB0014855D0 (en) 2000-06-16 2000-08-09 Isis Innovation Combining measurements from different sensors
US7261690B2 (en) 2000-06-16 2007-08-28 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
US6605038B1 (en) 2000-06-16 2003-08-12 Bodymedia, Inc. System for monitoring health, wellness and fitness
US7009946B1 (en) 2000-06-22 2006-03-07 Intel Corporation Method and apparatus for multi-access wireless communication
GB0016561D0 (en) 2000-07-05 2000-08-23 Rolls Royce Plc Health monitoring
AU2001272370A1 (en) 2000-07-19 2002-01-30 Medicotest A/S A skin electrode with a by-pass element
EP1304959A1 (en) 2000-07-24 2003-05-02 Motorola, Inc. Ingestible electronic capsule
US6564079B1 (en) 2000-07-27 2003-05-13 Ckm Diagnostics, Inc. Electrode array and skin attachment system for noninvasive nerve location and imaging device
JP4428835B2 (ja) 2000-08-09 2010-03-10 昭和電工株式会社 磁気記録媒体及びその製造方法
US20020026111A1 (en) 2000-08-28 2002-02-28 Neil Ackerman Methods of monitoring glucose levels in a subject and uses thereof
US7685005B2 (en) 2000-08-29 2010-03-23 Medtronic, Inc. Medical device systems implemented network scheme for remote patient management
DE60102331T2 (de) 2000-09-08 2005-03-17 Matsushita Electric Works, Ltd., Kadoma Datenübertragungssystem unter Verwendung eines menschlichen Körpers als Signalübertragungsweg
US6720923B1 (en) 2000-09-14 2004-04-13 Stata Labs, Llc Antenna design utilizing a cavity architecture for global positioning system (GPS) applications
US6572636B1 (en) 2000-09-19 2003-06-03 Robert Sean Hagen Pulse sensing patch and associated methods
WO2002027659A2 (en) 2000-09-26 2002-04-04 Advantage 3D Llc Method and system for generation, storage and distribution of omni-directional object views
US6773429B2 (en) 2000-10-11 2004-08-10 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
US7024248B2 (en) 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
US6327426B1 (en) * 2000-10-26 2001-12-04 Ceramatec, Inc. Apparatus and method for delivering a beneficial agent
WO2002034331A2 (en) 2000-10-26 2002-05-02 Medtronic, Inc. Externally worn transceiver for use with an implantable medical device
US6632175B1 (en) 2000-11-08 2003-10-14 Hewlett-Packard Development Company, L.P. Swallowable data recorder capsule medical device
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US6879810B2 (en) 2000-12-20 2005-04-12 Nokia Corporation Control of short range RF communication
JP2002263185A (ja) 2001-03-12 2002-09-17 Sanyo Electric Co Ltd 投薬システム及び方法及び投薬装置
JP2002290212A (ja) 2001-03-27 2002-10-04 Nec Corp 電圧制御発振器
US6342774B1 (en) 2001-03-27 2002-01-29 Motorola, Inc. Battery having user charge capacity control
EP1383575A4 (en) 2001-03-28 2010-01-20 Televital Inc SYSTEM AND METHOD FOR REAL-TIME MONITORING, INVESTIGATION, ANALYSIS, RECOVERY AND STORAGE OF PHYSIOLOGICAL DATA OVER A WIDE-FUTURE NETWORK (WAN)
US6595929B2 (en) 2001-03-30 2003-07-22 Bodymedia, Inc. System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow
US7407484B2 (en) 2001-04-06 2008-08-05 Medic4All Inc. Physiological monitoring system for a computational device of a human subject
US6694161B2 (en) 2001-04-20 2004-02-17 Monsanto Technology Llc Apparatus and method for monitoring rumen pH
US6801137B2 (en) 2001-04-23 2004-10-05 Cardionet, Inc. Bidirectional communication between a sensor unit and a monitor unit in patient monitoring
US6782290B2 (en) 2001-04-27 2004-08-24 Medtronic, Inc. Implantable medical device with rechargeable thin-film microbattery power source
DE60214698T2 (de) 2001-04-30 2007-09-13 Medtronic, Inc., Minneapolis Implantierbare medizinische vorrichtung und pflastersystem
JP2004529709A (ja) 2001-05-03 2004-09-30 テルズート・テクノロジーズ・インコーポレーテッド 医用無線監視装置及びシステム
US7039033B2 (en) 2001-05-07 2006-05-02 Ixi Mobile (Israel) Ltd. System, device and computer readable medium for providing a managed wireless network using short-range radio signals
GB0113212D0 (en) 2001-05-31 2001-07-25 Oxford Biosignals Ltd Patient condition display
US20020192159A1 (en) 2001-06-01 2002-12-19 Reitberg Donald P. Single-patient drug trials used with accumulated database: flowchart
AP2004002960A0 (en) 2001-06-19 2004-03-31 Digital Sports Media Physiological monitoring and system
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US6602518B2 (en) * 2001-06-28 2003-08-05 Wm. Wrigley Jr. Company Chewable product including active ingredient
US7783344B2 (en) 2003-08-20 2010-08-24 Philometron, Inc. Hydration monitoring
US7044911B2 (en) 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
EP2159723A1 (en) 2001-07-11 2010-03-03 CNS Response, Inc. Method for remote diagnosis and treatment using electroencephalografy
US20030017826A1 (en) 2001-07-17 2003-01-23 Dan Fishman Short-range wireless architecture
WO2003009920A1 (en) 2001-07-25 2003-02-06 Biosource, Inc. Electrode array for use in electrochemical cells
US6951536B2 (en) 2001-07-30 2005-10-04 Olympus Corporation Capsule-type medical device and medical system
US6747556B2 (en) 2001-07-31 2004-06-08 Medtronic Physio-Control Corp. Method and system for locating a portable medical device
US20030065536A1 (en) 2001-08-13 2003-04-03 Hansen Henrik Egesborg Portable device and method of communicating medical data information
WO2003015890A1 (en) 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
JP3962250B2 (ja) 2001-08-29 2007-08-22 株式会社レアメタル 生体内情報検出システム及びこれに用いるタグ装置、中継装置
US6650191B2 (en) 2001-09-07 2003-11-18 Texas Instruments Incorporated Low jitter ring oscillator architecture
US7122143B2 (en) * 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US6982094B2 (en) * 2001-09-28 2006-01-03 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
BR0212951A (pt) * 2001-09-28 2004-10-26 Mcneil Ppc Inc Formas de dosagens compósitas
US20050137480A1 (en) 2001-10-01 2005-06-23 Eckhard Alt Remote control of implantable device through medical implant communication service band
US6840904B2 (en) 2001-10-11 2005-01-11 Jason Goldberg Medical monitoring device and system
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US6745082B2 (en) 2001-10-22 2004-06-01 Jens Axelgaard Current-controlling electrode with adjustable contact area
US20030152622A1 (en) 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
US20030083559A1 (en) 2001-10-31 2003-05-01 Thompson David L. Non-contact monitor
US6643541B2 (en) 2001-12-07 2003-11-04 Motorola, Inc Wireless electromyography sensor and system
US20030107487A1 (en) 2001-12-10 2003-06-12 Ronen Korman Method and device for measuring physiological parameters at the wrist
GB0130010D0 (en) 2001-12-14 2002-02-06 Isis Innovation Combining measurements from breathing rate sensors
US7016648B2 (en) 2001-12-18 2006-03-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network
US7729776B2 (en) 2001-12-19 2010-06-01 Cardiac Pacemakers, Inc. Implantable medical device with two or more telemetry systems
US7877273B2 (en) 2002-01-08 2011-01-25 Fredric David Abramson System and method for evaluating and providing nutrigenomic data, information and advice
WO2003060808A2 (en) 2002-01-11 2003-07-24 Hexalog Sa Systems and methods for medication monitoring
US7519416B2 (en) 2002-02-04 2009-04-14 Heartview, Llc Diagnostic method utilizing standard lead ECG signals
IL154391A (en) 2002-02-11 2009-05-04 Given Imaging Ltd Self-propelled device
US20030162556A1 (en) 2002-02-28 2003-08-28 Libes Michael A. Method and system for communication between two wireless-enabled devices
US7043305B2 (en) 2002-03-06 2006-05-09 Cardiac Pacemakers, Inc. Method and apparatus for establishing context among events and optimizing implanted medical device performance
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US6968153B1 (en) 2002-03-13 2005-11-22 Nokia Corporation Apparatus, method and system for a Bluetooth repeater
US6957107B2 (en) 2002-03-13 2005-10-18 Cardionet, Inc. Method and apparatus for monitoring and communicating with an implanted medical device
US7188767B2 (en) 2002-03-18 2007-03-13 Precision Dynamics Corporation Physical condition or environmental threat detection appliance system
JP3869291B2 (ja) 2002-03-25 2007-01-17 オリンパス株式会社 カプセル型医療装置
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
US7376435B2 (en) 2002-04-01 2008-05-20 Intel Corporation Transferring multiple data units over a wireless communication link
US7797033B2 (en) 2002-04-08 2010-09-14 Smart Pill Corporation Method of using, and determining location of, an ingestible capsule
US7424268B2 (en) 2002-04-22 2008-09-09 Cisco Technology, Inc. System and method for management of a shared frequency band
EP1356762A1 (de) 2002-04-22 2003-10-29 UbiCom Gesellschaft für Telekommunikation mbH Geräteanordnung zur Fernüberwachung von Körperfunktionen
JP4347216B2 (ja) 2002-04-22 2009-10-21 マルシオ マルク アブリュー 生物学的パラメーターの測定装置
US20030216622A1 (en) 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
US7368190B2 (en) 2002-05-02 2008-05-06 Abbott Diabetes Care Inc. Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2003325439A (ja) 2002-05-15 2003-11-18 Olympus Optical Co Ltd カプセル型医療装置
AU2003233584A1 (en) 2002-05-20 2003-12-12 Stephen T. Flock Device and method for wound healing and uses therefor
US6847844B2 (en) 2002-06-06 2005-01-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of data communication with implanted device and associated apparatus
US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
US20040008123A1 (en) 2002-07-15 2004-01-15 Battelle Memorial Institute System and method for tracking medical devices
US6909878B2 (en) 2002-08-20 2005-06-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network
US7020508B2 (en) 2002-08-22 2006-03-28 Bodymedia, Inc. Apparatus for detecting human physiological and contextual information
US7294105B1 (en) 2002-09-03 2007-11-13 Cheetah Omni, Llc System and method for a wireless medical communication system
US7102508B2 (en) 2002-09-09 2006-09-05 Persephone, Inc. Method and apparatus for locating and tracking persons
US20040049245A1 (en) 2002-09-09 2004-03-11 Volker Gass Autonomous patch for communication with an implantable device, and medical kit for using said patch
GB2393356B (en) 2002-09-18 2006-02-01 E San Ltd Telemedicine system
US7388903B2 (en) 2002-09-18 2008-06-17 Conexant, Inc. Adaptive transmission rate and fragmentation threshold mechanism for local area networks
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
US6842636B2 (en) 2002-09-27 2005-01-11 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7736309B2 (en) 2002-09-27 2010-06-15 Medtronic Minimed, Inc. Implantable sensor method and system
US7209790B2 (en) 2002-09-30 2007-04-24 Medtronic, Inc. Multi-mode programmer for medical device communication
US7686762B1 (en) 2002-10-03 2010-03-30 Integrated Sensing Systems, Inc. Wireless device and system for monitoring physiologic parameters
US20040073454A1 (en) 2002-10-10 2004-04-15 John Urquhart System and method of portal-mediated, website-based analysis of medication dosing
US6959217B2 (en) 2002-10-24 2005-10-25 Alfred E. Mann Foundation For Scientific Research Multi-mode crystal oscillator system selectively configurable to minimize power consumption or noise generation
US7027871B2 (en) 2002-10-31 2006-04-11 Medtronic, Inc. Aggregation of data from external data sources within an implantable medical device
US20030126593A1 (en) 2002-11-04 2003-07-03 Mault James R. Interactive physiological monitoring system
US7232627B2 (en) 2002-11-08 2007-06-19 Honda Motor Co., Ltd. Electrode for solid polymer fuel cell
US20040092801A1 (en) 2002-11-13 2004-05-13 Budimir Drakulic System for, and method of, acquiring physiological signals of a patient
JP2006507885A (ja) 2002-11-29 2006-03-09 ギブン イメージング リミテッド 生体内診断の方法、装置及びシステム
WO2004052343A1 (en) 2002-12-11 2004-06-24 Pfizer Products Inc. Controlled-release of an active substance into a high fat environment
US20040167226A1 (en) 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
WO2004054430A2 (en) 2002-12-16 2004-07-01 Given Imaging Ltd. Device, system and method for selective activation of in vivo sensors
US7009511B2 (en) 2002-12-17 2006-03-07 Cardiac Pacemakers, Inc. Repeater device for communications with an implantable medical device
JP2006510431A (ja) 2002-12-19 2006-03-30 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ インピーダンス制御を有する電極アセンブリ及びシステム
US7127300B2 (en) 2002-12-23 2006-10-24 Cardiac Pacemakers, Inc. Method and apparatus for enabling data communication between an implantable medical device and a patient management system
DE10261748B4 (de) * 2002-12-30 2011-07-28 Mate Precision Tooling GmbH, 61440 Stanzwerkzeug
US6975174B1 (en) 2002-12-31 2005-12-13 Radioframe Networks, Inc. Clock oscillator
US7396330B2 (en) 2003-01-07 2008-07-08 Triage Data Networks Wireless, internet-based medical-diagnostic system
US20060142648A1 (en) 2003-01-07 2006-06-29 Triage Data Networks Wireless, internet-based, medical diagnostic system
US7512448B2 (en) 2003-01-10 2009-03-31 Phonak Ag Electrode placement for wireless intrabody communication between components of a hearing system
KR100873683B1 (ko) 2003-01-25 2008-12-12 한국과학기술연구원 인체통신방법, 인체통신시스템 및 이에 사용되는 캡슐형 내시경
KR100522132B1 (ko) 2003-01-25 2005-10-18 한국과학기술연구원 인체통신시스템에서의 데이터 수신방법 및 수신장치
RU2334506C2 (ru) 2003-01-29 2008-09-27 И-Пилл Фарма Лтд. Активная доставка лекарственного средства в желудочно-кишечном тракте
US7002476B2 (en) 2003-01-30 2006-02-21 Leap Of Faith Technologies, Inc. Medication compliance system
EP1443780B1 (en) 2003-01-30 2013-05-29 Accenture Global Services Limited Event data acquisition and transmission system
US7149581B2 (en) 2003-01-31 2006-12-12 Medtronic, Inc. Patient monitoring device with multi-antenna receiver
US7392015B1 (en) 2003-02-14 2008-06-24 Calamp Corp. Calibration methods and structures in wireless communications systems
US7215660B2 (en) 2003-02-14 2007-05-08 Rearden Llc Single transceiver architecture for a wireless network
US7653031B2 (en) 2003-03-05 2010-01-26 Timothy Gordon Godfrey Advance notification of transmit opportunities on a shared-communications channel
US7155232B2 (en) 2003-03-05 2006-12-26 Conexant Systems, Inc. Transmit request signaling between transceivers
US7321920B2 (en) 2003-03-21 2008-01-22 Vocel, Inc. Interactive messaging system
AU2004224345B2 (en) 2003-03-21 2010-02-18 Welch Allyn, Inc. Personal status physiologic monitor system and architecture and related monitoring methods
US20040193446A1 (en) 2003-03-27 2004-09-30 Mayer Steven Lloyd System and method for managing a patient treatment program including a prescribed drug regimen
US7245954B2 (en) 2003-03-27 2007-07-17 Given Imaging Ltd. Measuring a gradient in-vivo
GB0308114D0 (en) 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
GB0308467D0 (en) 2003-04-11 2003-05-21 Rolls Royce Plc Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components
FI116117B (fi) 2003-04-17 2005-09-30 Polar Electro Oy Mittalaite ja menetelmä sykkeen mittaamiseksi sekä mittalaitteen valmistusmenetelmä
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
AU2004233670B2 (en) 2003-04-25 2007-11-29 Olympus Corporation Radio-type in-subject information acquisition system and outside-subject device
US20040218683A1 (en) 2003-05-01 2004-11-04 Texas Instruments Incorporated Multi-mode wireless devices having reduced-mode receivers
US20040225199A1 (en) 2003-05-08 2004-11-11 Evanyk Shane Walter Advanced physiological monitoring systems and methods
TWI226761B (en) 2003-05-08 2005-01-11 Ind Tech Res Inst Dual band transceiver architecture for wireless application
US7031745B2 (en) 2003-05-12 2006-04-18 Shen Ein-Yiao Cellular phone combined physiological condition examination and processing device
JP4402655B2 (ja) 2003-05-14 2010-01-20 オリンパス株式会社 カプセル型医療装置
KR100542101B1 (ko) 2003-06-02 2006-01-11 삼성전자주식회사 전송 파워 제어 방법 및 이를 이용한 블루투스 장치
US7313163B2 (en) 2003-06-17 2007-12-25 Motorola, Inc. Fast synchronization for half duplex digital communications
US20040260154A1 (en) 2003-06-18 2004-12-23 Boris Sidelnik Human physiological and chemical monitoring system
EP2263513B1 (en) 2003-06-24 2013-08-07 Olympus Corporation Capsule type medical device communication system, capsule type medical device, and biological information reception device
EP1651101A1 (en) 2003-07-16 2006-05-03 Koninklijke Philips Electronics N.V. A portable electronic device and a health management system arranged for monitoring a physiological condition of an individual
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US7554452B2 (en) * 2003-07-18 2009-06-30 Cary Cole Ingestible tracking and locating device
US7653350B2 (en) 2003-07-24 2010-01-26 Sony Ericsson Mobile Communications Ab Wireless terminals and methods for communicating over cellular and enhanced mode bluetooth communication links
JP4038575B2 (ja) 2003-07-25 2008-01-30 独立行政法人産業技術総合研究所 バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法
US7243118B2 (en) 2003-07-30 2007-07-10 Broadcom Corporation Method and apparatus for efficient derivation of modulo arithmetic for frequency selection
US20050055014A1 (en) 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US7787946B2 (en) 2003-08-18 2010-08-31 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
JP4398204B2 (ja) 2003-08-29 2010-01-13 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
WO2005024687A1 (ja) 2003-09-02 2005-03-17 Fujitsu Limited 薬服用状況管理方法、薬剤及び薬服用状況管理装置
US20050062644A1 (en) 2003-09-08 2005-03-24 Leci Jonathan Ilan Capsule device to identify the location of an individual
JP3993546B2 (ja) 2003-09-08 2007-10-17 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
NZ580449A (en) 2003-09-11 2011-06-30 Theranos Inc Ingestible medical device with biocompatible polymer coating, device with microarray to interact with disease marker
US7499674B2 (en) 2003-09-12 2009-03-03 Nokia Corporation Method and system for repeat request in hybrid ultra wideband-bluetooth radio
US7352998B2 (en) 2003-09-12 2008-04-01 Nokia Corporation Method and system for establishing a wireless communications link
JP4153852B2 (ja) 2003-09-18 2008-09-24 オリンパス株式会社 エネルギー供給用コイルおよびこれを用いた無線型被検体内情報取得システム
WO2005031502A2 (en) 2003-09-22 2005-04-07 Kim Hyeung-Yun Methods for monitoring structural health conditions
US20090157358A1 (en) 2003-09-22 2009-06-18 Hyeung-Yun Kim System for diagnosing and monitoring structural health conditions
US7218967B2 (en) 2003-09-26 2007-05-15 Medtronic, Inc. System and method for real-time remote monitoring of implantable medical devices
US20050096514A1 (en) 2003-11-01 2005-05-05 Medtronic, Inc. Gastric activity notification
US6892590B1 (en) 2003-11-04 2005-05-17 Andermotion Technologies Llc Single-balanced shield electrode configuration for use in capacitive displacement sensing systems and methods
US7101343B2 (en) 2003-11-05 2006-09-05 Temple University Of The Commonwealth System Of Higher Education Implantable telemetric monitoring system, apparatus, and method
US20050101843A1 (en) 2003-11-06 2005-05-12 Welch Allyn, Inc. Wireless disposable physiological sensor
US7415242B1 (en) 2003-11-10 2008-08-19 Sprint Spectrum L.P. Method and system for proximity detection for an in-building wireless repeater
DE102004032812B4 (de) 2003-11-11 2006-07-20 Dräger Safety AG & Co. KGaA Kombinationssensor für physiologische Messgrößen
JP2005158770A (ja) 2003-11-20 2005-06-16 Matsushita Electric Ind Co Ltd 積層基板とその製造方法及び前記積層基板を用いたモジュールの製造方法とその製造装置
US6987691B2 (en) 2003-12-02 2006-01-17 International Business Machines Corporation Easy axis magnetic amplifier
US7427266B2 (en) * 2003-12-15 2008-09-23 Hewlett-Packard Development Company, L.P. Method and apparatus for verification of ingestion
US8306592B2 (en) 2003-12-19 2012-11-06 Olympus Corporation Capsule medical device
JP2005185567A (ja) 2003-12-25 2005-07-14 Olympus Corp 医療用カプセル装置
JP4198045B2 (ja) 2003-12-25 2008-12-17 オリンパス株式会社 被検体内位置検出システム
US7392091B2 (en) 2003-12-30 2008-06-24 Cochlear Limited Implanted antenna and radio communications link
JP2005192821A (ja) 2004-01-07 2005-07-21 Olympus Corp カプセル型医療装置
US7176784B2 (en) 2004-01-21 2007-02-13 Battelle Memorial Institute K1-53 Multi-mode radio frequency device
US7342895B2 (en) 2004-01-30 2008-03-11 Mark Serpa Method and system for peer-to-peer wireless communication over unlicensed communication spectrum
US7647112B2 (en) 2004-02-11 2010-01-12 Ethicon, Inc. System and method for selectively stimulating different body parts
US20050187789A1 (en) 2004-02-25 2005-08-25 Cardiac Pacemakers, Inc. Advanced patient and medication therapy management system and method
WO2005084533A1 (en) 2004-02-27 2005-09-15 Koninklijke Philips Electronics, N.V. Wearable wireless device for monitoring, analyzing and communicating physiological status
CN1284505C (zh) 2004-02-28 2006-11-15 重庆金山科技（集团）有限公司 医用无线电胶囊式内窥系统
US7406105B2 (en) 2004-03-03 2008-07-29 Alfred E. Mann Foundation For Scientific Research System and method for sharing a common communication channel between multiple systems of implantable medical devices
ATE448729T1 (de) 2004-03-04 2009-12-15 Olympus Corp Medizinisches system vom kapseltyp
GB0405798D0 (en) 2004-03-15 2004-04-21 E San Ltd Medical data display
JP4520198B2 (ja) 2004-04-07 2010-08-04 オリンパス株式会社 被検体内位置表示システム
US20050234307A1 (en) 2004-04-15 2005-10-20 Nokia Corporation Physiological event handling system and method
US8512219B2 (en) 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
JP2005304880A (ja) 2004-04-23 2005-11-04 Hitachi Ltd 非接触ｉｃタグを利用した体内物体管理システム
US8019471B2 (en) 2004-04-24 2011-09-13 Inrange Systems, Inc. Integrated, non-sequential, remote medication management and compliance system
US20050245794A1 (en) 2004-04-29 2005-11-03 Medtronic, Inc. Communication with implantable monitoring probe
GB0410248D0 (en) 2004-05-07 2004-06-09 Isis Innovation Signal analysis method
EP1750585A1 (en) 2004-05-16 2007-02-14 Medic4all AG Method and device for measuring physiological parameters at the hand
US7575005B2 (en) 2004-05-18 2009-08-18 Excel-Tech Ltd. Mask assembly with integrated sensors
US20050261559A1 (en) 2004-05-18 2005-11-24 Mumford John R Wireless physiological monitoring system
US7125382B2 (en) 2004-05-20 2006-10-24 Digital Angel Corporation Embedded bio-sensor system
KR100592934B1 (ko) 2004-05-21 2006-06-23 한국전자통신연구원 착용형 생체신호 검출모듈 및 이를 포함한 측정장치
US20050259768A1 (en) 2004-05-21 2005-11-24 Oki Techno Centre (Singapore) Pte Ltd Digital receiver and method for processing received signals
US7653542B2 (en) 2004-05-26 2010-01-26 Verizon Business Global Llc Method and system for providing synthesized speech
WO2005119610A1 (en) 2004-05-28 2005-12-15 Jan De Geest Communication unit for a person's skin
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
US7289855B2 (en) 2004-06-09 2007-10-30 Medtronic, Inc. Implantable medical device package antenna
WO2005123185A1 (en) 2004-06-10 2005-12-29 Ndi Medical, Llc Implantable system for processing myoelectric signals
US7697994B2 (en) 2004-06-18 2010-04-13 Medtronic, Inc. Remote scheduling for management of an implantable medical device
JP2006006377A (ja) 2004-06-22 2006-01-12 Elquest Corp 薬剤包装用の薬包紙
KR100615431B1 (ko) 2004-06-22 2006-08-25 한국전자통신연구원 생체신호 검출모듈, 다채널 커넥터 모듈 및 이를 포함한생체신호 검출장치
US20050285746A1 (en) 2004-06-25 2005-12-29 Sengupta Uttam K Radio frequency identification based system to track consumption of medication
US7206630B1 (en) 2004-06-29 2007-04-17 Cleveland Medical Devices, Inc Electrode patch and wireless physiological measurement system and method
US20070027383A1 (en) 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
US20060001496A1 (en) 2004-07-02 2006-01-05 Abrosimov Igor A Array oscillator and polyphase clock generator
JP4462614B2 (ja) 2004-07-05 2010-05-12 ソニー・エリクソン・モバイルコミュニケーションズ株式会社 近距離無線通信システム、携帯端末装置および無線通信装置
US7343186B2 (en) 2004-07-07 2008-03-11 Masimo Laboratories, Inc. Multi-wavelength physiological monitor
WO2006006158A1 (en) 2004-07-09 2006-01-19 Aerotel Medical Systems (1998) Ltd. Wearable device, system and method for measuring vital parameters
WO2006008740A1 (en) 2004-07-21 2006-01-26 Aerotel Medical Systems (1998) Ltd. Wearable device, system and method for measuring physiological and/or environmental parameters
CN100459614C (zh) 2004-07-22 2009-02-04 华为技术有限公司 一种手机外设装置与方法
US20080045843A1 (en) 2004-08-12 2008-02-21 Tomoharu Tsuji Via-Human-Body Information Transmission System and Transmitter-Receiver
US20060058602A1 (en) 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
US7253716B2 (en) 2004-08-17 2007-08-07 Tagent Corporation Trackable pills with electronic ID tags
US7317378B2 (en) 2004-08-17 2008-01-08 Tagent Corporation Product identification tag device and reader
CN101010114B (zh) 2004-08-27 2010-05-26 皇家飞利浦电子股份有限公司 电子遥控药丸和用于供应至少一种药物的系统
WO2006026741A1 (en) 2004-08-31 2006-03-09 Lifescan Scotland Limited Wearable sensor device and system
KR100727817B1 (ko) 2004-09-07 2007-06-13 한국전자통신연구원 인체를 매질로 이용한 통신장치 및 그 방법
JP4593211B2 (ja) * 2004-09-08 2010-12-08 オリンパス株式会社 カプセル型医療装置
AU2005281502A1 (en) 2004-09-08 2006-03-16 Alertis Medical As Sensor
GB2418144A (en) 2004-09-17 2006-03-22 Psimedica Ltd Medical device for delivery of beneficial substance
US20060065713A1 (en) 2004-09-24 2006-03-30 John Russell Kingery System and method for monitored administration of medical products to patients
US7341560B2 (en) 2004-10-05 2008-03-11 Rader, Fishman & Grauer Pllc Apparatuses and methods for non-invasively monitoring blood parameters
US20060078765A1 (en) 2004-10-12 2006-04-13 Laixia Yang Nano-structured ion-conducting inorganic membranes for fuel cell applications
JP2008011865A (ja) 2004-10-27 2008-01-24 Sharp Corp 健康管理装置及びこれを機能させるためのプログラム
ATE481920T1 (de) 2004-11-02 2010-10-15 Medtronic Inc Verfahren zur datenretention in einem implantierbaren medizinprodukt
US7917199B2 (en) 2004-11-02 2011-03-29 Medtronic, Inc. Patient event marking in combination with physiological signals
US20060095093A1 (en) 2004-11-04 2006-05-04 Ido Bettesh Apparatus and method for receiving device selection and combining
KR20060040500A (ko) 2004-11-06 2006-05-10 삼성전자주식회사 생체신호 측정 장치 및 방법
US7414534B1 (en) 2004-11-09 2008-08-19 Pacesetter, Inc. Method and apparatus for monitoring ingestion of medications using an implantable medical device
US7214107B2 (en) 2004-11-22 2007-05-08 Cardiodynamics International Corporation Electrical connector apparatus and methods
US8374693B2 (en) 2004-12-03 2013-02-12 Cardiac Pacemakers, Inc. Systems and methods for timing-based communication between implantable medical devices
US7154071B2 (en) 2004-12-07 2006-12-26 Dräger Safety AG & Co. KGaA Device for transmitting an electric signal detected by contact with the skin surface
US7978063B2 (en) 2004-12-13 2011-07-12 Koninklijke Philips Electronics N.V. Wireless network having body coupled communication for mobile patient monitoring
WO2006064502A2 (en) 2004-12-14 2006-06-22 E-Pill Pharma, Ltd. Local delivery of drugs or substances using electronic permeability increase
US20060136266A1 (en) 2004-12-20 2006-06-22 E-San Limited Medicinal product order processing system
US7146449B2 (en) 2004-12-22 2006-12-05 International Business Machines Corporation Bluetooth association with simple power connection
US7249212B2 (en) 2004-12-22 2007-07-24 International Business Machines Corporation Bluetooth association based on docking connection
EP1676522B1 (en) 2004-12-30 2008-07-02 Given Imaging Ltd. System for locating an in-vivo signal source
US20060148254A1 (en) 2005-01-05 2006-07-06 Mclean George Y Activated iridium oxide electrodes and methods for their fabrication
WO2006075016A1 (en) 2005-01-17 2006-07-20 Novo Nordisk A/S Fluide delivery device with integrated monitoring of physiological characteristics
US20080194912A1 (en) 2005-01-18 2008-08-14 Koninklijke Philips Electronics, N.V. Electronically Controlled Ingestible Capsule for Sampling Fluids in Alimentary Tract
JP2008532568A (ja) 2005-01-18 2008-08-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 電子制御されるカプセル
EP1841502A2 (en) 2005-01-18 2007-10-10 Koninklijke Philips Electronics N.V. Electronically controlled capsule for releasing radiation
WO2006077529A2 (en) 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. System for controlling traversal of an ingested capsule
JP4731936B2 (ja) 2005-02-09 2011-07-27 本田技研工業株式会社 回転式可変抵抗器
JP4099484B2 (ja) 2005-02-09 2008-06-11 株式会社カイザーテクノロジー 通信システム。
AU2006212007A1 (en) 2005-02-11 2006-08-17 The University Court Of The University Of Glasgow Sensing device, apparatus and system, and method for operating the same
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
DE102005007790B4 (de) * 2005-02-19 2007-06-28 Fette Gmbh Verfahren und Vorrichtung zur Versuchspressung von Mehrschichttabletten oder Manteltabletten
CA2601441A1 (en) 2005-03-21 2006-09-28 Abbott Diabetes Care Inc. Method and system for providing integrated medication infusion and analyte monitoring system
WO2006100620A1 (en) 2005-03-22 2006-09-28 Koninklijke Philips Electronics, N.V. Addressing scheme for smart wireless medical sensor networks
US20060216603A1 (en) 2005-03-26 2006-09-28 Enable Ipc Lithium-ion rechargeable battery based on nanostructures
US20060224326A1 (en) 2005-03-31 2006-10-05 St Ores John W Integrated data collection and analysis for clinical study
US7848820B2 (en) 2005-04-07 2010-12-07 St. Jude Medical Ab System and method for radio communication between an implantable medical device and an external base unit
US7270633B1 (en) 2005-04-22 2007-09-18 Cardiac Pacemakers, Inc. Ambulatory repeater for use in automated patient care and method thereof
US20060247505A1 (en) 2005-04-28 2006-11-02 Siddiqui Waqaas A Wireless sensor system
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
US7414543B2 (en) 2005-04-28 2008-08-19 Honeywell International Inc. Multiple miniature avionic displays
US7359674B2 (en) 2005-05-10 2008-04-15 Nokia Corporation Content distribution & communication system for enhancing service distribution in short range radio environment
US20070222556A1 (en) 2005-05-17 2007-09-27 Robbins Gene A Tracking system for distributable objects which are marked in single laser shot events with dynamically variable images
EP1885437A2 (en) * 2005-05-19 2008-02-13 E-Pill Pharma Ltd. Ingestible device for nitric oxide production in tissue
CN101217945B (zh) * 2005-05-20 2012-07-11 陶氏环球技术有限责任公司 使用射频识别标签的口服用药依从性监视
US8285205B2 (en) 2005-05-26 2012-10-09 Broadcom Corporation Method and system for a single chip integrated Bluetooth and FM transceiver and baseband processor
US20060273882A1 (en) 2005-06-01 2006-12-07 Intel Corporation RFID tag with separate transmit and receive clocks and related method
US20060276702A1 (en) 2005-06-03 2006-12-07 Mcginnis William Neurophysiological wireless bio-sensor
US7387607B2 (en) 2005-06-06 2008-06-17 Intel Corporation Wireless medical sensor system
WO2006133444A2 (en) 2005-06-09 2006-12-14 Medtronic, Inc. Implantable medical device with electrodes on multiple housing surfaces
US20060282001A1 (en) 2005-06-09 2006-12-14 Michel Noel Physiologic sensor apparatus
WO2006130988A1 (en) 2005-06-10 2006-12-14 Telecommunications Research Laboratories Wireless communication system
ITTO20050407A1 (it) 2005-06-13 2006-12-14 Ist Superiore Mario Boella Sistema di monitoraggio remoto di parametri fisiologici di un individuo, procedimento e prodotto informatico
US7782189B2 (en) 2005-06-20 2010-08-24 Carestream Health, Inc. System to monitor the ingestion of medicines
US7616111B2 (en) 2005-06-20 2009-11-10 Carestream Health, Inc. System to monitor the ingestion of medicines
US7299034B2 (en) 2005-06-21 2007-11-20 Lawrence Kates System and method for wearable electronics
US20080262320A1 (en) 2005-06-28 2008-10-23 Schaefer Timothy M System for Monitoring a Physical Parameter of a Subject
FI20055366A0 (fi) 2005-06-30 2005-06-30 Gen Electric Elektrodi biopotentiaalisignaalin saamiseksi
US20070016089A1 (en) 2005-07-15 2007-01-18 Fischell David R Implantable device for vital signs monitoring
EP3424421A3 (en) * 2005-07-20 2019-03-06 Neil R. Euliano Electronic pill for monitoring medication compliance
JP2009502248A (ja) 2005-07-22 2009-01-29 ダウ グローバル テクノロジーズ インコーポレイティド 音響検出を用いた経口薬遵守監視
CN100471445C (zh) 2005-08-01 2009-03-25 周常安 贴片式生理监测装置
US20090124871A1 (en) 2005-08-22 2009-05-14 Khalil Arshak Tracking system
US8116809B2 (en) 2005-08-29 2012-02-14 Intel Corporation Method and apparatus of multiple entity wireless communication adapter
US8827904B2 (en) 2005-08-31 2014-09-09 Medtronic, Inc. Automatic parameter status on an implantable medical device system
WO2007028035A2 (en) 2005-09-01 2007-03-08 Proteus Biomedical, Inc. Implantable zero-wire communications system
JP2007068622A (ja) 2005-09-05 2007-03-22 Olympus Corp 被検体内情報取得システム
JP2009507617A (ja) 2005-09-14 2009-02-26 ネオガイド システムズ， インコーポレイテッド 経腔的及び他の操作を行うための方法及び装置
WO2007031973A2 (en) 2005-09-15 2007-03-22 Visible Assets, Inc. Active low frequency radio tag and patch drug delivery system
US7673679B2 (en) 2005-09-19 2010-03-09 Schlumberger Technology Corporation Protective barriers for small devices
US20080058614A1 (en) 2005-09-20 2008-03-06 Triage Wireless, Inc. Wireless, internet-based system for measuring vital signs from a plurality of patients in a hospital or medical clinic
GB0519836D0 (en) 2005-09-29 2005-11-09 Smartlife Technology Ltd Contact sensors
US20070078324A1 (en) 2005-09-30 2007-04-05 Textronics, Inc. Physiological Monitoring Wearable Having Three Electrodes
GB0519945D0 (en) 2005-09-30 2005-11-09 Cambridge Silicon Radio Ltd Communication in dual protocol environments
CN100466966C (zh) 2005-10-08 2009-03-11 周常安 呼吸气流生理信号提取和监测装置及系统
US7377637B2 (en) * 2005-10-11 2008-05-27 Synergeyes, Inc. Hybrid contact lens system and method of fitting
US7733224B2 (en) 2006-06-30 2010-06-08 Bao Tran Mesh network personal emergency response appliance
US9154616B2 (en) 2005-10-18 2015-10-06 Oia Intellectuals, Inc. Wearable capture and communication
US7720036B2 (en) 2005-10-26 2010-05-18 Intel Corporation Communication within a wireless network using multiple frequency bands
US7499739B2 (en) 2005-10-27 2009-03-03 Smiths Medical Pm, Inc. Single use pulse oximeter
US8515348B2 (en) 2005-10-28 2013-08-20 Electro Industries/Gauge Tech Bluetooth-enable intelligent electronic device
US9067047B2 (en) 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
GB0523447D0 (en) 2005-11-17 2005-12-28 E San Ltd System and method for communicating environmentally-based medical support advice
US20070129769A1 (en) 2005-12-02 2007-06-07 Medtronic, Inc. Wearable ambulatory data recorder
US8295932B2 (en) 2005-12-05 2012-10-23 Metacure Limited Ingestible capsule for appetite regulation
NL1030608C2 (nl) 2005-12-06 2007-06-07 Patrick Antonius Hendri Meeren Blisterverpakking, samenstel van een blisterverpakking en een houder, alsmede werkwijze voor het verpakken van objecten.
CN1985752A (zh) 2005-12-19 2007-06-27 周常安 分布式生理信号监测设备
US20070156016A1 (en) 2005-12-29 2007-07-05 Ido Betesh Method and system for communication with an ingestible imaging device
US7678043B2 (en) 2005-12-29 2010-03-16 Given Imaging, Ltd. Device, system and method for in-vivo sensing of a body lumen
CA2635313C (en) 2005-12-29 2013-12-31 Osmotica Corp. Triple combination release multi-layered tablet
US8301254B2 (en) 2006-01-09 2012-10-30 Greatbatch Ltd. Cross-band communications in an implantable device
US20070162089A1 (en) 2006-01-09 2007-07-12 Transoma Medical, Inc. Cross-band communications in an implantable device
US8078278B2 (en) 2006-01-10 2011-12-13 Remon Medical Technologies Ltd. Body attachable unit in wireless communication with implantable devices
EP3510988B1 (en) * 2006-01-18 2021-07-14 Intec Pharma Ltd. Delivery device for oral intake of an agent
ATE441452T1 (de) 2006-01-23 2009-09-15 Koninkl Philips Electronics Nv Verbesserte biomedizinische elektrode zur längeren anwendung bei patienten mit einem deckel oder schnapper, der von der haltedichtung isoliert ist
US20070185393A1 (en) 2006-02-03 2007-08-09 Triage Wireless, Inc. System for measuring vital signs using an optical module featuring a green light source
US7809399B2 (en) 2006-02-10 2010-10-05 Syntek International Holding Ltd. Method and device for providing multiple communication protocols with a single transceiver
WO2007101141A2 (en) 2006-02-24 2007-09-07 Hmicro, Inc. A medical signal processing system with distributed wireless sensors
US20090023391A1 (en) 2006-02-24 2009-01-22 Koninklijke Philips Electronics N. V. Wireless body sensor network
US8200320B2 (en) 2006-03-03 2012-06-12 PhysioWave, Inc. Integrated physiologic monitoring systems and methods
US8457798B2 (en) 2006-03-14 2013-06-04 Jamie Hackett Long-range radio frequency receiver-controller module and wireless control system comprising same
US8920343B2 (en) 2006-03-23 2014-12-30 Michael Edward Sabatino Apparatus for acquiring and processing of physiological auditory signals
CN102323984A (zh) 2006-03-30 2012-01-18 陶氏环球技术有限责任公司 用于监控并分析体内用药方案的依从的方法与系统
TW200738212A (en) 2006-04-12 2007-10-16 Guo Terry Bo Jau Miniature wireless apparatus for collecting physiological signals of animals
DE102006017196B4 (de) * 2006-04-12 2008-09-11 Fette Gmbh Verfahren zur Regelung der Wirkstoffmenge von Tabletten während der Produktion in einer Rundläufertablettenpresse
US7912537B2 (en) 2006-04-27 2011-03-22 Medtronic, Inc. Telemetry-synchronized physiological monitoring and therapy delivery systems
GB0608829D0 (en) 2006-05-04 2006-06-14 Husheer Shamus L G In-situ measurement of physical parameters
WO2007128165A1 (fr) 2006-05-09 2007-11-15 Fangen Xiong Systèmes de réseaux sans fil courte portée et procédé de montage consistant à attribuer des créneaux temporels avec un émetteur-récepteur rf multivoie
US20080051647A1 (en) 2006-05-11 2008-02-28 Changwang Wu Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts
US7558622B2 (en) 2006-05-24 2009-07-07 Bao Tran Mesh network stroke monitoring appliance
EP2018741B1 (en) 2006-05-15 2013-02-20 Nokia Corporation Contactless programming and testing of memory elements
US7539533B2 (en) 2006-05-16 2009-05-26 Bao Tran Mesh network monitoring appliance
US20080074307A1 (en) 2006-05-17 2008-03-27 Olga Boric-Lubecke Determining presence and/or physiological motion of one or more subjects within a doppler radar system
CN101073494B (zh) 2006-05-18 2010-09-08 周常安 非侵入式生命迹象监测设备、系统及方法
US20070279217A1 (en) 2006-06-01 2007-12-06 H-Micro, Inc. Integrated mobile healthcare system for cardiac care
JP2009538720A (ja) 2006-06-01 2009-11-12 ビアンカメッド リミテッド 生理的徴候を監視するための装置、システム、および方法
US7346380B2 (en) 2006-06-16 2008-03-18 Axelgaard Manufacturing Co., Ltd. Medical electrode
EP2035075A1 (en) * 2006-06-20 2009-03-18 Koninklijke Philips Electronics N.V. Electronic capsule for treating gastrointestinal disease
US7949404B2 (en) 2006-06-26 2011-05-24 Medtronic, Inc. Communications network for distributed sensing and therapy in biomedical applications
US20080046038A1 (en) 2006-06-26 2008-02-21 Hill Gerard J Local communications network for distributed sensing and therapy in biomedical applications
US20080020037A1 (en) 2006-07-11 2008-01-24 Robertson Timothy L Acoustic Pharma-Informatics System
US7962174B2 (en) 2006-07-12 2011-06-14 Andrew Llc Transceiver architecture and method for wireless base-stations
US20080021521A1 (en) 2006-07-18 2008-01-24 Cardiac Pacemakers, Inc. Implantable Medical Device Communication System
DE102007020583B4 (de) 2006-07-19 2012-10-11 Erbe Elektromedizin Gmbh Elektrodeneinrichtung mit einerImnpedanz-Messeinrichtung und Verfahren zum Herstellen einer derartigen Elektrodeneinrichtung
US20090318761A1 (en) 2006-08-10 2009-12-24 Elisha Rabinovitz System and method for in vivo imaging
US20080097549A1 (en) 2006-09-01 2008-04-24 Colbaugh Michael E Electrode Assembly and Method of Using Same
US7756573B2 (en) 2006-09-05 2010-07-13 Cardiac Pacemakers, Inc. Implantable medical device diagnostic data acquisition and storage
US20080112885A1 (en) 2006-09-06 2008-05-15 Innurvation, Inc. System and Method for Acoustic Data Transmission
US8588887B2 (en) 2006-09-06 2013-11-19 Innurvation, Inc. Ingestible low power sensor device and system for communicating with same
US20090273467A1 (en) 2006-09-18 2009-11-05 Koninklijke Philips Electronics N. V. Ip based monitoring and alarming
US20080077028A1 (en) 2006-09-27 2008-03-27 Biotronic Crm Patent Personal health monitoring and care system
US20080077184A1 (en) 2006-09-27 2008-03-27 Stephen Denker Intravascular Stimulation System With Wireless Power Supply
RU2009116271A (ru) 2006-09-29 2010-11-10 Конинклейке Филипс Электроникс, Н.В. (Nl) Миниатюрные пороговые датчики
US20080091114A1 (en) 2006-10-11 2008-04-17 Pacesetter, Inc. Techniques for Correlating Thoracic Impedance with Physiological Status
US20080091089A1 (en) 2006-10-12 2008-04-17 Kenneth Shane Guillory Single use, self-contained surface physiological monitor
US8054140B2 (en) 2006-10-17 2011-11-08 Proteus Biomedical, Inc. Low voltage oscillator for medical devices
US20080097917A1 (en) 2006-10-24 2008-04-24 Kent Dicks Systems and methods for wireless processing and medical device monitoring via remote command execution
MY158019A (en) 2006-10-25 2016-08-30 Proteus Digital Health Inc Controlled activation ingestible identifier
US20080119705A1 (en) 2006-11-17 2008-05-22 Medtronic Minimed, Inc. Systems and Methods for Diabetes Management Using Consumer Electronic Devices
US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
CN101541237A (zh) 2006-11-21 2009-09-23 皇家飞利浦电子股份有限公司 可摄取电子胶囊以及体内给药或诊断系统
GB0624081D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
GB0624085D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
US20080137566A1 (en) 2006-12-06 2008-06-12 Bojko Marholev Method and System for Shared High-Power Transmit Path for a Multi-Protocol Transceiver
US20080146889A1 (en) 2006-12-13 2008-06-19 National Yang-Ming University Method of monitoring human physiological parameters and safty conditions universally
US8157730B2 (en) 2006-12-19 2012-04-17 Valencell, Inc. Physiological and environmental monitoring systems and methods
TWI334747B (en) 2006-12-22 2010-12-11 Unimicron Technology Corp Circuit board structure having embedded electronic components
KR20090106517A (ko) 2007-01-10 2009-10-09 카밀리오 리코디 모바일 긴급 경보 시스템
EP2104482A1 (en) * 2007-01-16 2009-09-30 Dow Global Technologies Inc. Oral drug capsule component incorporating a communication device
WO2008091683A2 (en) 2007-01-25 2008-07-31 Senior Vitals, Inc. System and method for physiological data readings, transmission and presentation
US20080183245A1 (en) 2007-01-31 2008-07-31 Van Oort Geeske Telemetry of external physiological sensor data and implantable medical device data to a central processing system
JP5524626B2 (ja) 2007-02-01 2014-06-18 プロテウス デジタル ヘルス， インコーポレイテッド 摂取可能な事象マーカシステム
US20080214985A1 (en) 2007-02-02 2008-09-04 Activatek, Inc. Active transdermal medicament patch
CN103066226B (zh) 2007-02-14 2016-09-14 普罗透斯数字保健公司 具有高表面积电极的体内电源
US20100055784A1 (en) 2007-03-02 2010-03-04 Mdrna, Inc. Nucleic acid compounds for inhibiting wnt gene expression and uses thereof
US8932221B2 (en) 2007-03-09 2015-01-13 Proteus Digital Health, Inc. In-body device having a multi-directional transmitter
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
US20080303638A1 (en) 2007-03-24 2008-12-11 Hap Nguyen Portable patient devices, systems, and methods for providing patient aid and preventing medical errors, for monitoring patient use of ingestible medications, and for preventing distribution of counterfeit drugs
KR100895297B1 (ko) 2007-04-30 2009-05-07 한국전자통신연구원 다양한 생체 신호의 동시 측정을 위한 다채널 전극센서장치
US20100256461A1 (en) 2007-05-01 2010-10-07 Urodynamix Technologies Ltd. Apparatus and methods for evaluating physiological conditions of tissue
GB0709248D0 (en) 2007-05-14 2007-06-20 T & Medical Ltd System for monitoring chemotherapy associated adverse drug reactions
US8412293B2 (en) 2007-07-16 2013-04-02 Optiscan Biomedical Corporation Systems and methods for determining physiological parameters using measured analyte values
US8115618B2 (en) 2007-05-24 2012-02-14 Proteus Biomedical, Inc. RFID antenna for in-body device
US20080300572A1 (en) 2007-06-01 2008-12-04 Medtronic Minimed, Inc. Wireless monitor for a personal medical device system
US8060175B2 (en) 2007-06-15 2011-11-15 General Electric Company System and apparatus for collecting physiological signals from a plurality of electrodes
US20080311852A1 (en) 2007-06-15 2008-12-18 Broadcom Corporation Multiple communication link coordination for shared data transmissions
GB2450517A (en) 2007-06-27 2008-12-31 Smartlife Technology Ltd Electrical resistance of yarn or fabric changes with temperature
JP5065780B2 (ja) 2007-07-03 2012-11-07 株式会社日立製作所 Ｒｆｉｄタグ実装基板
US20090009332A1 (en) * 2007-07-03 2009-01-08 Endotronix, Inc. System and method for monitoring ingested medication via rf wireless telemetry
JP4520491B2 (ja) 2007-07-09 2010-08-04 オリンパス株式会社 カプセル型医療システム
US8340750B2 (en) 2007-07-19 2012-12-25 Medtronic, Inc. Mechanical function marker channel for cardiac monitoring and therapy control
GB0714807D0 (en) 2007-07-30 2007-09-12 Oxford Biosignals Ltd Method and apparatus for measuring breathing rate
KR101080423B1 (ko) 2007-08-03 2011-11-04 삼성전자주식회사 멀티모듈결합형 휴대전자장치
KR100863064B1 (ko) 2007-08-03 2008-10-13 한국전자통신연구원 생체 신호 측정용 의복 및 그 제조 방법
US20090048498A1 (en) 2007-08-17 2009-02-19 Frank Riskey System and method of monitoring an animal
US20090062670A1 (en) 2007-08-30 2009-03-05 Gary James Sterling Heart monitoring body patch and system
KR101562807B1 (ko) 2007-09-07 2015-11-02 플로레, 잉고 진단 센서 유닛
WO2009036150A2 (en) 2007-09-11 2009-03-19 Aid Networks, Llc Wearable wireless electronic patient data communications and physiological monitoring device
WO2009036316A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Energy management, tracking and security for adherent patient monitor
WO2009036334A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Adherent multi-sensor device with empathic monitoring
FI2192946T3 (fi) 2007-09-25 2022-11-30 Elimistön sisäinen laite, jossa on virtuaalinen dipolisignaalinvahvistus
US20090088618A1 (en) 2007-10-01 2009-04-02 Arneson Michael R System and Method for Manufacturing a Swallowable Sensor Device
US20090105561A1 (en) 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US20090105567A1 (en) 2007-10-19 2009-04-23 Smiths Medical Pm, Inc. Wireless telecommunications network adaptable for patient monitoring
US8134459B2 (en) 2007-10-19 2012-03-13 Smiths Medical Asd, Inc. Wireless telecommunications system adaptable for patient monitoring
US8139225B2 (en) 2007-10-24 2012-03-20 Siemens Medical Solutions Usa, Inc. System for processing patient monitoring power and data signals
GB0721117D0 (en) 2007-10-26 2007-12-05 T & Medical Ltd system for assisting in drug dose optimisaion
US20090112626A1 (en) 2007-10-30 2009-04-30 Cary Talbot Remote wireless monitoring, processing, and communication of patient data
WO2009063377A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
WO2009070773A1 (en) 2007-11-27 2009-06-04 Proteus Biomedical, Inc. Transbody communication systems employing communication channels
US20090157113A1 (en) 2007-12-18 2009-06-18 Ethicon Endo-Surgery, Inc. Wearable elements for implantable restriction systems
CN101904119B (zh) 2007-12-20 2015-01-28 皇家飞利浦电子股份有限公司 电容感测和传达
JP5091657B2 (ja) 2007-12-21 2012-12-05 株式会社東芝 無線通信装置及び無線通信方法
US20090171180A1 (en) 2007-12-28 2009-07-02 Trevor Pering Method and apparatus for configuring wearable sensors
JP5052679B2 (ja) 2008-01-15 2012-10-17 カーディアック ペースメイカーズ， インコーポレイテッド アンテナを有する埋込型医療デバイス
US8401659B2 (en) 2008-01-15 2013-03-19 Cardiac Pacemakers, Inc. Implantable medical device with wireless communications
GB2456567B (en) 2008-01-18 2010-05-05 Oxford Biosignals Ltd Novelty detection
JP5132335B2 (ja) 2008-01-29 2013-01-30 富士フイルム株式会社 カプセル内視鏡及びカプセル内視鏡システム
JP5156427B2 (ja) 2008-02-13 2013-03-06 富士フイルム株式会社 カプセル内視鏡システム
CN104376659B (zh) 2008-03-05 2019-10-25 普罗透斯数字保健公司 多模式通信可摄取事件标记和系统，及使用其的方法
EP2249919B1 (en) 2008-03-06 2019-05-22 Stryker Corporation Foldable, implantable electrode array assembly
US20090243833A1 (en) 2008-03-31 2009-10-01 Ching Ching Huang Monitoring system and method for patient care
US20090253960A1 (en) 2008-04-03 2009-10-08 Olympus Medical Systems Corp. Antenna unit and receiving apparatus for capsule medical apparatus
WO2009131664A2 (en) 2008-04-21 2009-10-29 Carl Frederick Edman Metabolic energy monitoring system
AU2009260834B2 (en) 2008-06-18 2014-10-09 Covidien Lp System and method of evaluating a subject with an ingestible capsule
US20090318303A1 (en) 2008-06-20 2009-12-24 International Business Machines Corporation Microfluidic selection of library elements
US9014778B2 (en) 2008-06-24 2015-04-21 Biosense Webster, Inc. Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
CH699071A2 (fr) 2008-07-02 2010-01-15 Flakes S A Dispositif de freinage et/ou de blocage mécanique.
AU2009268734A1 (en) 2008-07-07 2010-01-14 Mario W. Cardullo Dynamically distributable nano RFID device and related method
ES2696984T3 (es) 2008-07-08 2019-01-21 Proteus Digital Health Inc Infraestructura de datos de marcadores de eventos de ingestión
WO2010011833A1 (en) 2008-07-23 2010-01-28 Alexander Stuck Secure tracking of tablets
CN104382598A (zh) 2008-08-13 2015-03-04 普罗透斯数字保健公司 一种产生识别器的方法
US20100056878A1 (en) 2008-08-28 2010-03-04 Partin Dale L Indirectly coupled personal monitor for obtaining at least one physiological parameter of a subject
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100063841A1 (en) 2008-09-05 2010-03-11 Vital Data Technology, Llc System and method of notifying designated entities of access to personal medical records
US20100069002A1 (en) 2008-09-16 2010-03-18 Vcan Sports, Inc. Method and apparatus for a wireless communication device utilizing bluetooth technology
TWI424832B (zh) 2008-12-15 2014-02-01 Proteus Digital Health Inc 與身體有關的接收器及其方法
JP5785097B2 (ja) 2009-01-06 2015-09-24 プロテウス デジタル ヘルス， インコーポレイテッド 薬学的投薬量送達システム
US8395521B2 (en) 2009-02-06 2013-03-12 University Of Dayton Smart aerospace structures
US8073401B2 (en) 2009-02-17 2011-12-06 Rfaxis, Inc. Multi mode radio frequency transceiver front end circuit with inter-stage matching circuit
CA2789521A1 (en) 2009-02-25 2010-09-02 Xanthia Global Limited Wireless physiology monitor
US8452366B2 (en) 2009-03-16 2013-05-28 Covidien Lp Medical monitoring device with flexible circuitry
US8805528B2 (en) 2009-03-31 2014-08-12 Medtronic, Inc. Channel assessment and selection for wireless communication between medical devices
NZ619375A (en) 2009-04-28 2015-03-27 Proteus Digital Health Inc Highly reliable ingestible event markers and methods for using the same
WO2010132331A2 (en) 2009-05-12 2010-11-18 Proteus Biomedical, Inc. Ingestible event markers comprising an ingestible component
US20110230732A1 (en) 2009-09-14 2011-09-22 Philometron, Inc. System utilizing physiological monitoring and electronic media for health improvement
UA109424C2 (uk) * 2009-12-02 2015-08-25 Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки
WO2011112972A2 (en) 2010-03-11 2011-09-15 Philometron, Inc. Physiological monitor system for determining medication delivery and outcome
US9872637B2 (en) 2010-04-21 2018-01-23 The Rehabilitation Institute Of Chicago Medical evaluation system and method using sensors in mobile devices
CN103154929A (zh) 2010-06-14 2013-06-12 特鲁塔格科技公司 用于生产具有标识符的包装物品的系统
KR101760663B1 (ko) 2010-06-14 2017-08-04 트루테그 테크놀로지스, 인코포레이티드 패키지에서 아이템을 검증하기 위한 시스템
WO2011159337A1 (en) 2010-06-14 2011-12-22 Trutag Technologies, Inc. Labeling and verifying an item with an identifier
WO2011159336A1 (en) 2010-06-14 2011-12-22 Trutag Technologies, Inc. System for verifying an item in a package using a database
KR101450493B1 (ko) 2010-09-13 2014-10-13 노키아 코포레이션 햅틱 통신

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1650844A (zh) * 1999-08-05 2005-08-10 美商戴冕勋食品公司 可食性全息照相产品,具体药剂及其产生方法与装置
US20060028727A1 (en) * 2002-08-20 2006-02-09 Moon John A Method and apparatus for drug product tracking using encoded optical identification elements
US20060210626A1 (en) * 2005-03-17 2006-09-21 Spaeder Jeffrey A Radio frequency identification pharmaceutical tracking system and method
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging

Also Published As

Publication number Publication date
EP2774595A3 (en) 2014-12-03
JP2013512737A (ja) 2013-04-18
CN102724948A (zh) 2012-10-10
CN104323917B (zh) 2017-10-17
DK2774595T3 (en) 2017-07-17
HK1201717A1 (zh) 2015-09-11
KR20120098853A (ko) 2012-09-05
ES2533801T3 (es) 2015-04-14
MY156819A (en) 2016-03-31
WO2011068963A2 (en) 2011-06-09
EP2774595B1 (en) 2017-04-19
US8784308B2 (en) 2014-07-22
MX2012006414A (es) 2013-01-29
UA109424C2 (uk) 2015-08-25
ES2629746T3 (es) 2017-08-14
JP2017225826A (ja) 2017-12-28
TW201127369A (en) 2011-08-16
EP2774595A2 (en) 2014-09-10
CA2782683A1 (en) 2011-06-09
JP2019076745A (ja) 2019-05-23
ZA201306692B (en) 2015-06-24
JP2016052585A (ja) 2016-04-14
BR112012013504A2 (pt) 2016-06-07
EP2506820B1 (en) 2015-02-18
ZA201204128B (en) 2013-11-27
US20120116359A1 (en) 2012-05-10
IL220126A0 (en) 2012-07-31
EP2506820A4 (en) 2013-05-29
WO2011068963A3 (en) 2011-10-20
HK1176854A1 (zh) 2013-08-09
DK2506820T3 (da) 2015-04-27
EP2506820A2 (en) 2012-10-10
AU2010326002A1 (en) 2012-06-21
KR101771532B1 (ko) 2017-08-25
IL220126A (en) 2015-06-30
JP6189403B2 (ja) 2017-08-30
SG181489A1 (en) 2012-07-30
US20170296799A1 (en) 2017-10-19
AU2010326002B2 (en) 2015-09-24
TWI532478B (zh) 2016-05-11
CN104323917A (zh) 2015-02-04
JP2022019835A (ja) 2022-01-27
US20150112243A1 (en) 2015-04-23

Similar Documents

Publication Publication Date Title
CN103405341A (zh) 与药物制品整合的可摄入的事件标记系统
US20230034761A1 (en) Ingestible device with pharmaceutical product
JP6689324B2 (ja) 小型の摂取可能なデバイス
JP5869639B2 (ja) 摂取可能なイベントマーカの高生産性製造

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1186092

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20131127

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1186092

Country of ref document: HK