CN103357384A - Special adsorbent for metabolic substance in serum - Google Patents
Special adsorbent for metabolic substance in serum Download PDFInfo
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- CN103357384A CN103357384A CN2012100906267A CN201210090626A CN103357384A CN 103357384 A CN103357384 A CN 103357384A CN 2012100906267 A CN2012100906267 A CN 2012100906267A CN 201210090626 A CN201210090626 A CN 201210090626A CN 103357384 A CN103357384 A CN 103357384A
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- adsorbent
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Abstract
The application relates to the field of medical apparatus, and in particular relates to a special medical absorbent. According to the special absorbent, the surface of the absorbent is at least coated with a coating, and the material on the outmost layer of the coating is a polymer containing polyanion.
Description
Technical field that the present invention belongs to
The application relates to medical instruments field, particularly relates to a species specificity Medical Adsorbents.
The prior art background
The blood perfusion therapy is the medical device technology that twentieth century rises, and is reducing the infringement of medicine to patient's vitals, improves the disease therapeuticing effect aspect and plays very important effect.For example: use Medical Adsorbents and remove excess metabolism material in the blood, be proved to be a kind of more successful medicine equipment.
For improving adsorbent to the selective and blood compatibility effect of metabolic material in the serum, can also be at adsorbent surface coating polymer, not only can reduce the adsorbent surface material comes off, and can reduce the infringement that causes because adsorbent surface is coarse blood cell, can also increase adsorbent specific area and regulation and control adsorbent aperture by coating, thereby the enhancing adsorption function reaches the purpose for the treatment of.
Yet because the complexity of the interior physiology of human body and pathology, there is the problem of complicated biocompatibility in adsorbent in blood perfusion, when polymer is overlayed on adsorbent surface simultaneously, has equally the problem of biocompatibility.At present, polymeric material commonly used mainly contains: GMA (GMA) and triallyl cyanurate (TAC), these polymer are commercial Application at the beginning of using.Biocompatibility is relatively poor.
Therefore, existing adsorbent easily causes the complication such as comparatively serious thrombus or haemolysis because selective and biocompatibility is relatively poor.
The content of invention
For solving the problems of the technologies described above, the application implements to provide a kind of to Metabolites in serum matter selectivity adsorbent.Technical scheme is as follows:
One species specificity adsorbent, described adsorbent surface is coating one deck coating at least, and the material of outermost layer coating is the polymer that contains polyanion in the described coating.
Select GMA (GMA) and triallyl cyanurate (TAC) to carry out suspension polymerisation, prepare have electrostatic interaction, the gel-type adsorbent of the polyanion of diffusion, hydrophobic and hydrogen bond action, this adsorbent has preferably absorption property to LDL.
One, polymerisation
Take into account in the there-necked flask of reflux condensing tube in tool agitator, temperature, the adding polyvinyl alcohol is dispersant, adds GMA and the TAC of amount of calculation, carries out suspension polymerisation under nitrogen protection, and the GT copolymer that makes gel-type is for subsequent use.
Two, hydroxylating
Add sodium hydride (NaH) in dimethyl formamide (DMF) solvent of dihydroxylic alcohols, making the mol ratio of NaH and dihydroxylic alcohols is 2～4: 1, is warming up to 65 ℃～70 ℃, and reaction 1～2h filters.Then add the GT copolymer cross with the DMF swelling in advance to filtrate, cooling behind stoichiometric number under 65 ℃～90 ℃ temperature hour, filtration get the hydroxylating copolymer.With its washing, methyl alcohol extracts, and dries, and vacuum drying is for subsequent use to constant weight.
Three, sulfonating reaction
The hydroxylating copolymer is moved on among the DMF, and place the water salt bath, then drip chlorosulfonic acid, finish, reaction 2h transfers to alkalescence with dilute alkaline soln, reacts filtration in 0.5～2.0 hour, is washed to neutrality, methyl alcohol extracts, and dries, and vacuum drying makes gel-type GT adsorbent.
The GT adsorbent is to the existing excellent absorption property of LDL in the serum
The selectivity advantages of good adsorption effect of GT adsorbent can reach 31.7% to the adsorption rate of T-CHOL in the serum, and the adsorption rate of LDL is reached 47.5%, and HDL is not adsorbed substantially, adsorption rate only 1.4%, its advantage is:
1. selected raw material GT and the TAC of this gel-type GT adsorbent all is that hydrophily is stronger, and itself just has antimicrobial ability, and blood compatibility is good.
2.GT adsorbent belongs to the gel-type adsorbent, without permanent duct, just energy swelling in the aqueous solution makes its surface that certain micropore be arranged, and instrument is difficult to record, and this is conducive to HDL and is not adsorbed.(if 6.5～9.5mm) adsorbents are macroporous type, then HDL easily is adsorbed, and is unfavorable for keeping useful HDL because the HDL particle diameter is little.
Claims (2)
1. synthetic method to Metabolites in serum matter selectivity adsorbent is characterized in that:
The cancellation chloromethyl is made catalyst, directly carries out the macroporous adsorbent that cross-linking reaction is made into.
2. as claimed in claim synthetic method is characterized in that:
One, cross-linking reaction
Archon is placed in the solvent vessel ratio; 10 kilograms of absolute ethyl alcohol 30L of Archon, 125 gram ferric trichlorides.Heat twice of 75 degree reactions 24 hours of stirring is rear crosslinked.Obtain specific area greater than 900n? g, aperture are greater than the macroporous absorbent resin of 10nm.
Two, post-processed
Alkali is dropped in the reactor of 100L water ratio; 500 gram alkali, 100L water were warmed up to 80 degree reactions after 8 hours, alternately cleaned with the first alcohol and water.The residue of the ferric trichloride that retains in crosslinked after removing.Acquisition does not have the adsorbent of chlorine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100906267A CN103357384A (en) | 2012-03-31 | 2012-03-31 | Special adsorbent for metabolic substance in serum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100906267A CN103357384A (en) | 2012-03-31 | 2012-03-31 | Special adsorbent for metabolic substance in serum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103357384A true CN103357384A (en) | 2013-10-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100906267A Pending CN103357384A (en) | 2012-03-31 | 2012-03-31 | Special adsorbent for metabolic substance in serum |
Country Status (1)
| Country | Link |
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| CN (1) | CN103357384A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4246351A (en) * | 1976-10-28 | 1981-01-20 | Asahi Kasei Kogyo Kabushiki Kaisha | Protein adsorbent |
| CN101224415A (en) * | 2007-09-30 | 2008-07-23 | 南开大学 | Low density lipoprotein adsorbent for extrinsic blood perfusion and preparing method thereof |
| CN102049242A (en) * | 2011-01-08 | 2011-05-11 | 广州康盛生物科技有限公司 | Anion resin for bilirubin absorption and preparation method thereof |
-
2012
- 2012-03-31 CN CN2012100906267A patent/CN103357384A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4246351A (en) * | 1976-10-28 | 1981-01-20 | Asahi Kasei Kogyo Kabushiki Kaisha | Protein adsorbent |
| CN101224415A (en) * | 2007-09-30 | 2008-07-23 | 南开大学 | Low density lipoprotein adsorbent for extrinsic blood perfusion and preparing method thereof |
| CN102049242A (en) * | 2011-01-08 | 2011-05-11 | 广州康盛生物科技有限公司 | Anion resin for bilirubin absorption and preparation method thereof |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131023 |