CN1033368C - 静脉注射装置及系统 - Google Patents

静脉注射装置及系统 Download PDF

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CN1033368C
CN1033368C CN93116864A CN93116864A CN1033368C CN 1033368 C CN1033368 C CN 1033368C CN 93116864 A CN93116864 A CN 93116864A CN 93116864 A CN93116864 A CN 93116864A CN 1033368 C CN1033368 C CN 1033368C
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B·A·本克
G·A·蒂尔
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Grasby Medicine Co. Ltd.
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Abstract

一适用以装纳一钝头插管的静脉注射装置，包括：一具有一通道和一弹性体中隔件的壳体，该通道从其外端向内延伸，该中隔件密封地装纳在壳体的通道中。该中隔件具有一从中隔件的内端延伸进入但不穿过中隔件的孔，一从中隔件的外端大致在轴向方向延伸进入中隔件直至其孔的狭缝。当插管穿过中隔件的狭缝时，中隔件的弹性体材料被移动进入中隔件的孔中，从而沿中隔件的孔密封地接合该插管。

Description

静脉注射装置及系统
本发明涉及主要进行输液治疗及静脉注射装置，尤其是适用于与钝头插管一起使用的静脉注射装置。
在努力减少经针头意外事故而传递如肝炎和爱滋病的传染病的风险的过程中，已经设计了各种静脉注射装置，这些装置适用以装纳一钝头插管和/或防护的插管。参见例如：专栏报道及产品回顾“针头保护装置，健康装置”一文，第154-180页(1991美国滨夕法尼亚州急救护理研究所(ECRI)普利茅斯(Plymouth))会议)。一种方法须采用一具狭缝中隔件丫-座，其中一具狭缝弹性体中隔件压缩在丫座装置之壳体中。一钝头插管可插入穿过中隔件的狭缝，并且，假使设计如所希望的那样起作用，则中隔件将密封该插管杆部。当插管移去时，中隔件便自身密封。
这种类型之注射装置从下列公司获得或由下列公司出版说明，即美国Illinois州Deerfield城Baxter国际公司(其商品名为“Baxter的无针注射装置”)，Illinois州Abbott Park的Abbott制药公司(其商品名为“生命罩感染控制系统”)及California州Irvine城的Kendall Me Gaw制药公司(其商品名为“安全线无针静脉注射系统”)。一种钝头插管可从美国New Jersey州Paramus城Becton，Dickinson公司获得，其商品名为“连接系统”。
这些系统的一个问题是它们有时是不相容的。有些带狭缝的中隔件系统在插管插入或在没有插管插入时有可能存在泄漏现象。在至少具单个狭缝的中隔件装置中，有可能借助于利用一非特定的插管或借助于试图将插管在狭缝以外的其它地方插入穿过中隔件材料而破坏处于其壳体中的中隔件。
本发明提供了一种静脉注射装置，系统及方法，以便通过该带钝头插管的装置注射静脉药液；其中该装置适用于在其中对插管的密封作出改进并产生可靠的密封，并且将插管插入该装置所需的力是相当小的。
一般地说，本发明之静脉注射装置包括：一个有一外端和一通道的壳体，该通道从该处端向内延伸并限定一轴向方向，一弹性体中隔件密封地装纳于壳体通道中。该中隔件相对于壳体外端具有内、外端，一孔从该中隔件的内端通常沿轴向方向伸展进入该中隔件但不穿过该中隔件；一狭缝大致沿轴向方向从该中隔件的外端伸展进入该中隔件直至上述孔处。该壳体包括构成通道的中隔件装纳部分的内、外环状凸缘。该内凸缘与邻近其周界的中隔件内端接合，而该外凸缘与邻近其周界的中隔件外端接合。这一结构使得当插管插入穿过中隔件的狭缝时，中隔件单性体材料膨胀进入中隔件的孔中，从而沿中隔件的孔密封地与插管接合。
中隔件的孔直径最好比插管插入中隔件的狭缝中之前的插管的直径大，当插管插入穿过狭缝时，因中隔件之材料运动使其孔的截面减小，以致中隔件沿其孔与插管密封地接合。
该结构使得中隔件的孔和狭缝部分每个都对插管具有独立密封的作用。这由因狭缝膨胀将材料移动导向到该孔而取得。中隔件也可设计成使得中隔件从其壳体中适当的位置移动或破坏的危险性减小。
其它特征将在下面说明。
参见附图对本发明作出进一步说明。其中在整个的几幅附图中相应的参考标号说明相应的部件。其中
图1是静脉注射装置的放大剖视图，其中示出了新颖的中隔件及壳体设计；
图2是图1的静脉注射装置的顶视图；
图3是图1中隔件的剖视图，其中示出了它组装于静脉注射装置的壳体中之前的构成；
图4是图1和图2的静脉注射装置和一钝头插管的放大剖视图，其中示出了插管插入其中之前的静脉注射装置。
图5是图4的静脉注射装置及插管的放大剖视图，其中示出了插管部分地插入注射装置中。
图6是图4和图5的静脉注射装置及插管的放大剖视图，其中示出了插管基本上完全插入了注射装置中；
图7是本发明的静脉注射装置的另一个实施例的放大剖视图。
现在，参见附图，本发明之静脉注射装置之整体由标号10标明。该注射装置10可以是通常称之为丫-座装置的型式，其设置以一密封的入口以将注射液注入静脉插管装置(未示出)内。可设想该注射装置10可用于诸如静脉内给药的插管装置，小药瓶或其它涉及药液或药物凝固体的药液系统中。注射装置10尤其是设计成与塑料或金属制成的钝头插管12(图4-6)一起使用，该插管具有相当光滑之端14，从而减少针头意外伤害病人的危险性。
注射装置10通常包括一壳体16，该壳体16具有一外端18及从外端18开始向内伸展的通道20。该通道20限定一轴向方向。一弹性体中隔件22密封地装纳于壳体16的通道20中。中隔件22相对于壳体16的外端18具有内、外端24和26。孔28通常在轴向方向从中隔件22的内端24伸入该中隔件22，但不穿过该中隔件22。狭缝30通常在轴向方向从中隔件22的外端26伸入到该中隔件中，一直伸至孔28处。
该结构使得当插管12插入并穿过中隔件22的狭缝30时，中隔件22的弹性体材料膨胀进入中隔件22的孔28，从而沿着中隔件22的孔28密封地将插管接合住。
壳体16包括相对的内、外环形凸缘32和34，并限定通道20的中隔件装纳部分(也包括21)。该内凸缘32与邻近其周界部分的中隔件22的内端24接合。而该外凸缘34与邻近其周界部分的中隔件22的外端26接合。通道20的中隔件装纳部分21通常是圆柱形的。
在组装该静脉注射装置10期间，当将该中隔件22插入壳体16中之前，以先将该中隔件22加工成如图3所示的截头锥形/圆柱形相组合的构形为好。组装前之中隔件22包括大致为截头锥形的部分36和一大致为等直径的圆柱部分38。该锥形部分36邻近中隔件22的内端24并在朝着内端24的方向向下收缩，该圆柱部分38从该截头锥形部分36处开始伸展至中隔件22的外端26。在组装该静脉注射装置10期间，当中隔件22插入壳体16中后，该中隔件22由壳体16在径向压缩，从而具有大致圆柱形的构形。
中隔件22的孔28延伸通过25％至50％的中隔件而中隔件22的狭缝30延伸通过50％至75％的中隔件为最好，中隔件22的截头锥形部分36从中隔件22的内端24开始延伸的距离的距离比孔28从中隔件22的内端24开始延伸的距离大。作为中隔件22装配前的尺寸的一个示例，孔28可具有大约0.105英寸(2.7mm)的深度；狭缝30具有大约0.129英寸(3.3mm)的深度(沿中隔件22之轴向)；截头锥形部分36可具有大约0.164英寸(4mm)的长度；圆柱部分38可具有大约0.070英寸(1.8mm)长度。在组装该注射装置10期间，当该中隔件22插入壳体16中这些尺寸可在某种程度上有些变化。
通道20的中隔件装纳部分21由具有基本上等直径的圆柱形的壁(也包括21)构成。该安装部分确定为内、外凸缘32和34之间的部分21。
中隔件装纳部分21的直径最好比中隔件22的截头锥形部分36装配前的最小直径大，但比中隔件22的截头锥形部分或圆柱形部分38装配前的最大直径小。例如，壳体16的中隔件装纳部分21的直径大约为0.290英寸(7.4mm)；与截头锥形部分36之最大值径相等的圆柱部分38的装配前直径大约0.322英寸(8.2mm)；而截头锥形部分36的装配前的最小直径大约0.280英寸(7.1mm)。
该结构使得最大之压缩作用发生在邻近中隔件22的外端。在上述示例中，壳体16的壁作用于圆柱部38上的压缩将圆柱部分之直径从未压缩构形减少大约10％。图3虚线示出了装入壳体16中后中隔件22之构形。
壳体16的外凸缘34限定一大致为圆形的孔40，在此处，中隔件22的外端26露出穿过壳体16的外端18。中隔件22的外端24包括一环形凸脊42和一环形槽沟44。该环形凸脊42延伸穿过大致为圆形的孔40，该环形槽沟44与环形凸脊42同心，并具有比环形凸脊42之直径大的直径。外凸缘34具有一设于中隔件22的环形槽沟44中的环形内边46。
例如，中隔件22的环形凸脊42可能具有一大约0.16英寸(4.1mm)的外径，与中隔件22的中心轴同心，具有一大约0.12英寸(3.0mm)的内直径，以及一大致为半圆形之横截面构形，横截面半径大约为0.01英寸(0.25mm)。
狭缝30是在模制的中隔件22中，由一小刀片(未示出)切削而成为好，该刀片可由中隔件22之外表面26轴向地插入。作为示例，如果待用于中隔件22中的最大可能的插管12的直径为大约0.05-0.1英寸(1.3-2.5mm)，则狭缝30之长度(沿中隔件22之侧向)可能为大约0.03-0.08英寸(0.76-2.0mm)。
狭缝切削刀片(未示出)最好具有大约0.045英寸(1.14mm)的宽度，从而切削出一具有大约0.045英寸(1.14mm)长的狭缝30。人们相信在与可从美国依利诺州Deerfield城Baxter国际公司获得的其商品名称为“无针注射插管”的插管以及可从美国Illinois州AbbottPark城的Abbott制药公司获得的其商品名称为“生命罩感染控制系统”中的插管一起使用时为最好。Baxter的“无针注射插管”的外直径为大约0.100英寸(2.5mm)，Abbott的“生命罩”插管之外直径为大约0.05英寸(1.27mm)。
中隔件22的孔28的孔径最好比插管12装入中隔件22的狭缝30中之前的直径大。当插管12装入穿过狭缝30中(图5)时，中隔件22的孔28之截面由于被插管12所移动导致中隔件22的材料运动而减小，所以中隔件沿着中隔件22的孔28密封地接合插管12。
例如，中隔件22组装前的孔28较好为大致呈圆柱形的并具有大约0.120英寸(3.05mm)的直径，人们相信具该直径大小的孔28对具有大约0.100英寸(2.5mm)的外直径的插管12是优选的。由于中隔件22压缩地安装于壳体16的中隔件装纳部分21中，因此中隔件22的孔28在注射装置10组装后比组装前小。
中隔件22以用合适的弹性体材料整体模压制成为好，例如用聚异戊二烯(天然的或合成的)材料。最好的聚异戊二烯材料是合成的并且有肖氏A级硬度大约为35，并且具有压缩系数约为16.4％。适用的聚异戊二烯材料包括“5281或5251号树胶橡胶”，其可从美国依利诺州Abbott Park城Abbott制药公司获得；还包括“1028号树胶橡胶”和可从美国滨夕法尼亚州Phoenixville城西部公司获得的目录号为“2-2-3 7389-35”及“2-6-2X 7389-35”的材料及可从美国Ohio州Painesville城的Neff Perkins公司获得的目录号为No.L3819”的材料，可从Neff Perkins公司目录号“L4795”下获得的硅有机树酯配方也适用的。
本文所用之“整体模压”是指压制成一块连续材件，相对于由若干材件机械地放置在一起制成的。因此这种结构将使从狭缝30中移动之材料主要用以收缩孔28的直径。
壳体16以由适当的合成树脂材料注射模压而成为较好，例如可由丙烯腈-丁二烯-苯乙烯材料(即ABS材料)制成。壳体16之材料在正常应用时与中隔件22的弹性体材料相比相对而言是不可屈服的，因此通道20的中隔件装纳部分21的壁在狭缝30由插管12使之膨胀时不产生明显之膨胀。因此，该一结果导致了通道20的中隔件装纳部分21的壁及内外凸缘32和34帮助将中隔件22中移出的材料用以使孔28收缩。
外凸缘34最好是用旋转模锻使其在中隔件22的外端26的范围内向内弯曲，从而将中隔件22夹持在壳体16中。也可设想该外凸缘34可用超声变形或由热空气/冷铁钻锻打工艺使其对着中隔件22的外端26弯曲。另外，壳体16可模压成多于一块材件，这些材件组装在一起以将中隔件22夹持就位。
该静脉注射装置10可以是如附图中示出的制成丫-座装置(也用标号10)，带有一上游臂48及一下游臂50和中隔件装纳部分21。上游臂48和下游臂50的内壁限定一沿中隔件22的内端24延伸并与通道20流体连通的腔52。该上游臂48和下游臂50适用于装在常规的静脉插管(未示出)的端部。
下游臂50从中隔件装纳部分21同轴线地延伸，使得插入中隔件22的插管12的端14不会被下游臂50的腔限定壁所阻止。下游臂50最好是从中隔件22的外端26朝下延伸一距离，该距离比插管12预期的长度大，从而使静脉插管(未示出)之下游部分与插管12的端部14的可能接触被隔离开。
该静脉注射装置10可安置在公开于美国专利US 4236880，4277226，4322201，4637817，4673390，4705506，4714463及5017192的插管装置型式，这些专利都示出输液治疗系统。在这样的系统中，一注射装置10可沿相对于输液泵(未示出)的插管装置上游部分设置，并且另一注射装置10可沿输液泵的插管装置下游部分设置。
上游的静脉注射装置10带有一方便结构，以便将第二液源连接到多种溶液静脉治疗系统，该系统公开于美国专利US 4637817,4673390，4705506及4714463中。
注射装置10也可用于常规的重力流动静脉插管装置(未示出)之中。该装置是设计成不用输液泵，也可用于带小药瓶的插管装置或其它治疗用注射装置中。
图7示出了静脉注射装置的另一实施例，这里标之以标号10A的装置相似于注射装置10，但其中中隔件22A的内端24A包括一从中隔件22A开始轴向伸展的环形裙件100(在图7中参考标号后的“A”表示其它图中没有“A”的相同标号所表示的零部件)。壳体16A的内凸缘32A包括一用以装纳中隔件22A的裙件100的环形装纳槽沟102。
裙件100和裙件装纳槽沟102帮助在壳体16A中的中隔件22A保持稳定，并且裙件100和槽沟102的相对尺寸可在插管12插入装置10A时便于对孔28A的直径的变化进行微调。如图7所示，槽沟的深度比裙件100的长度还大，从而当插管12使狭缝30A膨胀时为中隔件22A的弹性体材料的膨胀提供了空间，其结果就是孔28A的直径将不象注射装置10中孔28的直径收缩得那么多。另外裙件装纳槽沟102具有一基本上等于裙件100长度的长度，所以因插管12插入穿过狭缝30A而移动的大多数材料将用以使孔28A的直径收缩。
另一个注射装置10A的中隔件22A还可包括一沿其外端的周界上的环状阶梯形肩状部106，使得壳体16A的外端18A大致高于中隔件22A的外端26A。外凸缘34A可用超声波进行弯曲以使中隔件22A保持就位。
可设想中隔件22A将是锥形的(可能的话相似于中隔件22)，使得最大的径向压缩作用发生于邻近中隔件22A的外表面26A处。
尽管不是最佳的或未示出，中隔件装纳部分可以另外具有锥形外形，使邻接于壳体外端处具有最小的直径，从而沿外表面比沿中隔件其它地方产生更大的压缩，然而这一结构却导致注射器的组装更加困难。组装多部件壳体(未示出)将是制造带这种锥形中隔件装纳部分的壳体的一种途径。这种多部件壳体可以包括一个或多个不同颜色的部件以表示注射装置打算与钝头插管一起使用。
现在说明静脉注射装置10的工作状况。首先，将插管12插入到中隔件22的狭缝30中。当进行这种插入工作时，插管12使中隔件22的弹性体材料膨胀，从而使狭缝30变大以便容纳插管12。由于中隔件22的材料实际上是不可压缩的，因此由插管12移动的中隔件22的弹性体材料由壳体16将之导向中隔件22的孔28中，从而减小孔28的直径。中隔件22的孔28的直径减小到小于或等于插管12的直径。
然后借助于将插管12继续插入穿过狭缝30中而将插管12插入中隔件22的孔径28中。这就导致了中隔件22沿其孔28密封地接合插管12。由于中隔件22的孔28的直径已减小至小于或等于插管12的直径，因此当插管12插入中隔件22的孔28中时，中隔件22之弹性体材料沿着其孔28压靠在插管12上。
当插管12从注射装置10中移走时，中隔件22回复至其正常的构形，并且密封狭缝30以防止泄漏。
在不脱离本发明的范围可对上述结构和方法作出各种改变，故希望所有包含在上面描述的及示于所示附图中的主题都应该认为已经示意性地作了说明，但在任何意义上不作为限制这些说明。

Claims (13)

1.静脉注射装置(10，10A)，适用以装纳一钝头插管(12)，
该注射装置(10，10A)包括：
一带有一外端(18，18A)及一通道(20，20A)的壳体(16，16A)，该通道从外端(18，18A)开始向内延伸并限定一轴向方向；
一密封地装纳于壳体(16，16A)的通道(20，20A)中的弹性体中隔件(22，22A)，该中隔件(22，22A)相对于壳体(16，16A)的外端(18，18A)具有内、外端(24及26，26A)，一狭缝(30，30A)从该中隔件(22，22A)的外端(26，26A)基本沿轴向延伸进入该中隔件(22，22A)直到孔(28，28A)处；
该壳体(16，16A)包括相对置的内、外环形凸缘(32和34；32A和34A)，它们限定通道(20，20A)的中隔件装纳部分(21)，内凸缘(32，32A)与邻近其周界的中隔件(22，22A)的内端(24)接合，而外凸缘(34，34A)与邻近其周界的中隔件(22，22A)的外端(26，26A)接合；其特征在于，该中隔件(22，22A)具有一孔(28，28A)，该孔(28，28A)从中隔件(22，22A)的内端开始，大致在该狭缝(30，30A)的轴向方向延伸进入中隔件(22，22A)，该结构使得当一插管(12)插入穿过中隔件(22，22A)的狭缝(30，30A)时，中隔件(22，22A)的弹性材料移动进入中隔件(22，22A)的孔(28，28A)中，从而沿中隔件(22，22A)的孔(28，28A)密封接合该插管(12)。
2.一包括一钝头的、且具有一外直径大致为圆柱形的插管(12)和一适用以装纳该钝头插管(12)的静脉注射装置(10，10A)的连接系统，该注射装置(10，10A)包括：
一带有一外端(18，18A)及一通道(20，20A)的壳体(16，16A)，该通道(20，20A)从该外端(18，18A)开始向内延伸，该通道(20，20A)限定一轴向方向；
一密封地装纳于壳体(16，16A)的通道(20，20A)中的弹性体中隔件(22，22A)，该中隔件(22，22A)相对于壳体(16，16A)的外端(18，18A)具有内(24)及外端(26，26A)，一狭缝(30，30A)从该中隔件(22，22A)的外端(26，26A)基本沿轴向延伸进入该中隔件(22，22A)直到孔(28，28A)处；
该壳体(16，16A)包括相对置的内、外环形凸缘(32和34；32A和34A)，它们限定通道(20，20A)的中隔件装纳部分(21)，该内凸缘(32，32A)与邻近其周界的中隔件(22，22A)的内端(24)接合，而外凸缘(34，34A)与邻近其周界的中隔件(22，22A)的外端(26，26A)接合；其特征在于，该中隔件(22，22A)具有一孔(28，28A)，该孔(28，28A)从中隔件(22，22A)的内端(24)开始大致在该狭缝(30，30A)的轴向方向延伸进入而不穿过该中隔件(22，22A)，该结构使得当一插管(12)插入穿过中隔件(22，22A)的狭缝(30，30A)时，中隔件(22，22A)的弹性体材料移动进入中隔件(22，22A)的孔(28，28A)中，从而沿中隔件(22，22A)的孔(28，28A)密封地接合该插管(12)。
3.如权利要求2所述连接系统，其特征在于，该中隔件(22，22A)的孔(28，28A)之直径在插管(12)插入中隔件(22，22A)的狭缝(30，30A)中之前比插管(12)的直径大，但当插管(12)插入穿过狭缝(30，30A)时，因中隔件(22，22A)的材料的运动，孔(28，28A)的截面减小，因此中隔件(22，22A)沿其孔(28，28A)密封地接合该插管(12)。
4.如权利要求1或2和3中之一分别所述静脉注射装置(10，10A)或连接系统，其特征在于，该通道(20)的中隔件装纳部分(21)大致呈圆柱形；在组装该静脉注射装置(10)期间，在将中隔件插入壳体(16)中之前，该中隔件(22)被加工成其构形包括一邻近中隔件(22)的内端(24)呈大致截头锥形的部分(36)，并且朝内端(24)的方向向下收缩，该中隔件(22)由壳体(16)进行径向压缩，从而在组装该静脉注射装置(10，10A)期间，在将中隔件(22)插入壳体(16)中后，使该中隔件(22)具有一大致为圆柱形的构形。
5.如权利要求4所述的静脉注射装置(10，10A)或连接系统，其特征在于，在组装该静脉注射装置(10，10A)之前，通道(20)由一大致圆柱形壁构成，该壁具有大致恒定的直径，且该直径大于该中隔件(22)的截头锥形部分(36)的最小直径，但该直径小于该中隔件(22)的截头锥形部分(36)的最大直径。
6.如权利要求5所述的静脉注射装置(10，10A)或连接系统，其特征在于，组装该静脉注射装置(10)之前，中隔件(22)包括一从截锥形部分(36)延伸至中隔件(22)外端(26)的大致恒定的圆柱形部分，该截头锥形部分(36)从中隔件(22)的内端(24)延伸的距离大于孔(28)从中隔件(22)的内端(24)延伸的距离。
7.如权利要求6的所述静脉内注射装置(10，10A)或系统，其特征在于，壳体(16)的外凸缘(34)限定一大致圆形的孔(40)，此时，中隔件(22)的外端(26)露出穿过壳体(16)的外端(18)，中隔件(22)的外端(26)包括一延伸穿过大致圆形的孔(40)的环形凸脊(42)。
8.如权利要求7所述静脉注射装置(10，10A)或连接系统，其特征在于，中隔件(22)的外表面(26)设有一与环形凸脊(42)同心的、其直径比环形凸脊(42)直径大的环形槽沟(44)，外凸缘(34)具有一装纳于该中隔件(22)的该环形槽沟(44)中的环形内边(46)。
9.如权利要求1或2所述静脉内注射装置(10，10A)或连接系统，其特征在于，中隔件(22A)的内端包括一从该中隔件(22A)轴向向内延伸的环形裙件(100)，壳体(16A)的内凸缘(32A)包括一用以装纳中隔件(22)的裙件(100)的环形裙件装纳槽沟(102)。
10.如权利要求1或2和3中之一所述静脉注射装置(10，10A)或连接系统，其特征在于，中隔件(22，22A)的孔(28，28A)延伸通过中隔件(22，22A)的25％-50％，而中隔件(22，22A)的狭缝(30，30A)延伸通过中隔件(22，22A)的50-75％。
11.如权利要求1或2和3中之一所述静脉注射装置(10)或连接系统，其特征在于，该静脉注射装置(10)是装于静脉插管装置上的Y-座装置(10)。
12.在如权利要求2所述的静脉注射装置(10，10A)与钝头插管(12)之间形成密封性连接的方法，该方法的步骤包括：
将插管(12)插入中隔件(22，22A)的狭缝(30，30A)中，从而用插管(12)使中隔件(22，22A)的弹性体材料膨胀而加大狭缝(30，30A)以便装纳插管(12)；其特征在于，该方法包括下列步骤：
将由插管(12)所移动的中隔件(22，22A)的弹性体材料导向中隔件(22，22A)的孔(28，28A)中，从而减小该孔(28，28A)的直径；以及
通过将插管(12)继续插入穿过狭缝(30，30A)而将插管(12)插入到中隔件(22，22A)的孔(28，28A)中，使得该中隔件(22，22A)沿其孔(28，28A)密封地接合插管(12)。
13.如权利要求12所述的方法，其特征在于，中隔件(22，22A)的孔(28，28A)在插管(12)插入中隔件(22，22A)的狭缝(30，30A)中之前，其直径比插管(12)的直径大；导向由插管(12)所移动的中隔件(22，22A)的弹性体材料的步骤包括，将中隔件(22，22A)的孔(28，28A)的直径减小至小于或等于插管(12)的直径，以致当插管(12)插入中隔件(22，22A)的孔(28，28A)中时，使中隔件(22，22A)的弹性体材料沿其孔(28，28A)压靠在插管(12)上。
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AU667232B2 (en) 1996-03-14
EP0652788A1 (en) 1995-05-17
CA2140787A1 (en) 1994-02-17
MX9304486A (es) 1995-01-31
AU4676293A (en) 1994-03-03
US5405331A (en) 1995-04-11
CN1087831A (zh) 1994-06-15
US5300034A (en) 1994-04-05
ATE142518T1 (de) 1996-09-15
JPH07509387A (ja) 1995-10-19
EP0652788B1 (en) 1996-09-11
WO1994003231A1 (en) 1994-02-17
DE69304706D1 (de) 1996-10-17
ES2095067T3 (es) 1997-02-01
SG47400A1 (en) 1998-04-17
DK0652788T3 (zh) 1997-03-17
DE69304706T2 (de) 1997-05-07

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