CN103315833A - Targeted drug delivery tube woven intravascular stent - Google Patents
Targeted drug delivery tube woven intravascular stent Download PDFInfo
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- CN103315833A CN103315833A CN2013102396028A CN201310239602A CN103315833A CN 103315833 A CN103315833 A CN 103315833A CN 2013102396028 A CN2013102396028 A CN 2013102396028A CN 201310239602 A CN201310239602 A CN 201310239602A CN 103315833 A CN103315833 A CN 103315833A
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- tubing
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- blood vessel
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Abstract
The invention provides a targeted drug delivery tube woven intravascular stent which comprises a stent and a conveying system. The stent is arranged on the external side of the end portion of the conveying system; the end portions of the stent and the conveying system can be connected through a catheter (3); the stent is formed by a plurality of tubes which are spirally woven according to spiral angles to enable the stent form into a cylindrical shape; connecting bodies (5) can be connected between stents. Accordingly, the targeted drug delivery tube woven intravascular stent has the advantages of being capable of effectively improving the drug therapy effect, reducing adverse drug reactions, enabling local drug concentration to be controllable, overcoming the defects that possible corresponding complications and damage of intimae in the traditional intravascular stents and enabling a directional local drug delivery stent which is utilized as an important part of achievement of a targeted drug delivery system to be established with the help of medical equipment.
Description
Technical field
The present invention relates to medical instruments field, particularly relate to a kind of human vas support.Realize an important component part of targeting drug delivery system behind this stentplacement human vas by setting up the directed local administration, prevent restenosis, tumor and inflammatory reaction etc., to reach the purpose of disease in prevention and the treatment blood vessel.
Background technology
In recent years, for the artery occlusion that atherosclerosis causes, implant expandable stent, the Therapeutic Method of promoting blood flow is popularized rapidly, has become the Main Means of myocardial revascularization and has obtained very good effect at present.Multiple support is arranged at present clinically, though emphasis is different, but version directly affects clinical therapeutic efficacy, at present desirable support should be: have good mechanical property, be difficult for forming thrombosis, histocompatibility is good, restenosis rate is low, NIP reaction, clinical accident rate be low, do not affect blood flow, easy to use, easy to operate, low price etc.
At present, the coronary artery bracket of domestic and international main flow, as: Cypher support, Taxus support, Multi-link support, S-Stent support, Libert é support, Excel support, Partner support, Firebird support etc. all are to adopt laser engraving to form, the Driver support adopts metal wire knitted to form only, the version of these supports is different, and result of use cuts both ways.Be divided into from manufacture characteristic: two kinds of laser engraving and establishment processing.Laser engraving is the coronary artery bracket preparation method that belongs to traditional (patent of invention number: CN101745153 A, patent of invention number: CN102497838 A, patent of invention number: CN101249030B), basically all be to adopt the tubing cut, the electrobrightening processing and fabricating, also has groove type intravascular stent (patent of invention number: CN101879102 A, CN102368978 A) or many micropore brackets (patent of invention number: CN102283727 A patent of invention number:, patent of invention number: CN102309368 A) also be the tubing cut after, surface laser capillary processing or electrochemical reaction form, and these supports stimulate the reaction that is inflamed because the corner angle that form during cutting easily cause blood vessel wall in use; The coronary artery bracket of establishment processing is except arteria coronaria Driver support, biliary tract or esophageal stents appear adopt this preparation method more, the method that adopts when making bracket for eluting medicament is all consistent, with medicament dissolution in polymer, process by spraying coating process such as ultrasound wave or immersions, form medication coat at rack outer surface, can not realize the targeted delivery of drugs function.
Summary of the invention
The technical problem that the present invention mainly solves provides a kind of target administration tubing braided blood vessel stent, by designing a kind of intravascular stent, can realize the targeted delivery of drugs function, this support can effectively improve medication effect, reduce adverse effect, local drug concentration is controlled, its treatment field is extensive, overcome the defective that corresponding complication and arterial intima may appear in traditional intravascular stent, be the research direction of the local disease of therapeutic treatment blood vessel, and set up the important component part that the directed local administration bracket is the realization targeting drug delivery system by medical apparatus and instruments.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: a kind of target administration tubing braided blood vessel stent is provided, comprises rack body and induction system; Described rack body is arranged at the outside, end of described induction system, and the end of described rack body and induction system can link to each other by conduit (3); Described rack body is spiraled to weave by helical angle by tubing and makes described support form the column profile; Link to each other by connector (5) between described rack body and the rack body.
A kind of target administration tubing braided blood vessel stent according to claim 1, it is characterized in that: the tubing of described rack body is hollow type tubing, the surface of tubing is provided with the micropore of evagination (1).
A kind of target administration tubing braided blood vessel stent according to claim 2, it is characterized in that: the aperture of described micropore is the 10-100% of pipe internal diameter.
A kind of target administration tubing braided blood vessel stent according to claim 2, it is characterized in that: the tubing of described rack body is curved tubing, is interconnected to form spiral-shaped column profile by a plurality of U-shaped structures (4) on axially.
Preferably, described rack body inside can install for detection of blood flow, blood pressure, be organized into the monitoring sensor of the index of grading.
Preferably, described rack body can be made by one or more materials in rustless steel, cochrome, Nitinol, biodegradable polymers material or biodegradable metal, pure magnesium, magnesium alloy, pure iron or the ferroalloy.
Beneficial effect of the present invention:
The special consideration of a kind of target administration tubing of the present invention braided blood vessel stent on material uses the hollow tubular product braiding to form, and the processing and manufacturing cost is low, avoids mechanical damage in use, reduces inflammatory reaction, and goes for more patient crowd.Say from medical effect, the present invention can effectively improve medication effect, reduce adverse effect, local drug concentration is controlled, overcome the defective that corresponding complication and arterial intima may appear in traditional intravascular stent, setting up the directed local administration bracket by medical apparatus and instruments is an important component part that realizes targeting drug delivery system.
A kind of target administration tubing of the present invention braided blood vessel stent makes this platform become the several functions such as the treatment of a collection, assessment, detection and is novel apparatus platform all over the body for assessment, the evaluation means on this apparatus platform provides the foundation.
Description of drawings
Fig. 1 is the structural representation of a kind of target administration tubing of the present invention braided blood vessel stent;
Fig. 2 is the flat deployable structure schematic diagram of a kind of target administration tubing of the present invention braided blood vessel stent;
Fig. 3 is the interior targeting administration schematic diagram of the blood vessel of a kind of target administration tubing of the present invention braided blood vessel stent;
Fig. 4 is the microcellular structure schematic diagram of tube surfaces evagination;
Fig. 5 is the structural representation that adjacent two supports participate in connection;
Fig. 6 is the structural representation of the eject scaffold tube formula induction system of a kind of target administration tubing of the present invention braided blood vessel stent;
Fig. 7 is the structural representation of the balloon expandable stent induction system of a kind of target administration tubing of the present invention braided blood vessel stent;
The labelling of each parts is as follows in the accompanying drawing: 1, micropore; 2, supporter; 3, conduit; 4, U-shaped structure; 5, connector; 6, epitheca pipe I; 7, dilator; 8, push rod; 9, foley's tube; 10, epitheca pipe II; 11, sacculus.
The specific embodiment
Below in conjunction with accompanying drawing preferred embodiment of the present invention is described in detail, thereby so that advantages and features of the invention can be easier to be it will be appreciated by those skilled in the art that protection scope of the present invention is made more explicit defining.
The embodiment of the invention comprises:
The technical scheme that this invention support adopts is: a kind of target administration tubing braided blood vessel stent is provided, and it can be used as coronary artery bracket, carotid stents, cerebral aneurysm support or periphery intraluminal stent etc.This target administration tubing braided blood vessel stent comprises support and induction system; Support is arranged at the outside, end of described induction system, and the end of described support and induction system links to each other by conduit 3; Described support is comprised of some tubing, and tubing spirals to weave by helical angle and makes described support form the column profile, helical angle scope 30 80 degree, and optimum is 45 75 degree.Described tubing can be by rustless steel, cochrome, Nitinol, and one or more materials in biodegradable polymers material or biodegradable metal, pure magnesium, magnesium alloy, pure iron or the ferroalloy are made.
Described induction system can be divided into catheter type induction system and expanding induction system, and the catheter type induction system mainly comprises epitheca pipe I 6, dilator 7, push rod 8; The expanding induction system mainly comprises foley's tube 9 and epitheca pipe II 10, forms the sacculus 11 that struts after the expansion.
Described tubing is hollow type tubing, and tubing is curved tubing, is interconnected by 4 to 10 U-shaped structures (the best is 6 to 8) and forms the equal in length of U-shaped structure 4 supported on both sides bodies 2, U-shaped structure 4 symmetrical center line A
1With axis C
1Folded angle is identical with helical angle.The surface of tubing is provided with the micropore 1 of evagination, and described micropore 1 is formed by laser engraving, and the shape of micropore is circular, also can be conical, semicircle, ellipse or polygon.These micropores are conducive to directed affected part 12 administrations, and micropore diameter is 10 100% of pipe internal diameter, and optimum is 20 80%, and micropore 1 quantity on each U-shaped structure 4 depends on diameter and the arrangement pitch of micropore, and general 2 20, optimum is 4 10.
Can link to each other by connector 5 between described support and the support, connector 5 can be polylactic acid, polyglycolic acid, poly-(lactic acid-6-caprolactone), poly-Biodegradable polymerics such as (glycolic-6-caprolactones), the number of connector 5 is 1 10, optimum is 26, connector 5 can be parallel with axis, also can fold certain angle with axis.
Described induction system can arrive appointed part by transfer gantry, after support is then opened naturally, realizes the directed local administration functions.Described internal stent can be installed for detection of blood flow, blood pressure, be organized into the monitoring sensor of the index of grading.Described internal stent can pass into high-temp liquid or gas is realized the local heat function.
The present invention is a kind of target administration tubing braided blood vessel stent, plays effective prevention and suppresses the diseases such as vascular restenosis, treatment Intravascular Thrombus and tumor for the targeted delivery of drugs function by support being inserted blood vessel, for the patient provides a kind of effective protection.
The work medium-height trestle is cylindrical, has on the one hand the support blood vessels function, by surface micropore medicament is continued to discharge in the blood vessel on the other hand, becomes bare bracket after releasing.
The operation principle of support of the present invention is: support is pressed in advance and is held in the transmitter epitheca pipe, is delivered to the blood vessel appropriate location in the operation, then discharges.Now to be illustrated as example from swollen intravascular stent, the dispose procedure medium-height trestle at first is pushed out the epitheca pipe, when support was pushed out the epitheca pipe, support naturally expanded and opens, and support is close on the blood vessel wall, the end of support links to each other by conduit with conveyor end, medicinal liquid is injected into internal stent by carrier, and rack surface evagination micropore is aimed at diseased region and realized the targeted delivery of drugs function, has implemented administration recession sheath pipe, disengage to support and transmitter, finish the dispose procedure of support.
Support of the present invention mainly is comprised of support and induction system, if client need target administration, can inject medicinal liquid by induction system, also can realize the slow dispose procedure of medicament in the support, realize the effect of drug stent, and do not need pharmaceutical carrier, overcome conventional medicament support polymer support and the defective that corresponding complication and bare bracket may arterial intima may occur.And the present invention helps the development of support manufacturing technology, and the industry contribution is very large, and the probability of industry application is very large.In addition, support of the present invention, it utilizes hollow tubular product braiding typing processing and manufacturing, so the industrialization manufacturing feasibility is very large.
The above only is embodiments of the invention; be not so limit claim of the present invention; every equivalent structure or equivalent flow process conversion that utilizes description of the present invention to do; or directly or indirectly be used in other relevant technical fields, all in like manner be included in the scope of patent protection of the present invention.
Claims (6)
1. a target administration tubing braided blood vessel stent comprises rack body and induction system; It is characterized in that: described rack body is arranged at the outside, end of described induction system, and the end of described rack body and induction system can link to each other by conduit (3); Described rack body is spiraled to weave by helical angle by tubing and makes described support form the column profile; Link to each other by connector (5) between described rack body and the rack body.
2. a kind of target administration tubing braided blood vessel stent according to claim 1, it is characterized in that: the tubing of described rack body is hollow type tubing, the surface of tubing is provided with the micropore of evagination (1).
3. a kind of target administration tubing braided blood vessel stent according to claim 2, it is characterized in that: the aperture of described micropore is the 10-100% of pipe internal diameter.
4. a kind of target administration tubing braided blood vessel stent according to claim 2, it is characterized in that: the tubing of described rack body is curved tubing, is interconnected to form spiral-shaped column profile by a plurality of U-shaped structures (4) on axially.
5. a kind of target administration tubing braided blood vessel stent according to claim 1 is characterized in that: described rack body inside can be installed for detection of blood flow, blood pressure, is organized into the monitoring sensor of the index of grading.
6. a kind of target administration tubing braided blood vessel stent according to claim 1 is characterized in that: can being made by one or more materials in rustless steel, cochrome, Nitinol, biodegradable polymers material or biodegradable metal, pure magnesium, magnesium alloy, pure iron or the ferroalloy of described rack body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102396028A CN103315833A (en) | 2013-06-17 | 2013-06-17 | Targeted drug delivery tube woven intravascular stent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102396028A CN103315833A (en) | 2013-06-17 | 2013-06-17 | Targeted drug delivery tube woven intravascular stent |
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| CN103315833A true CN103315833A (en) | 2013-09-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2013102396028A Pending CN103315833A (en) | 2013-06-17 | 2013-06-17 | Targeted drug delivery tube woven intravascular stent |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104814818A (en) * | 2015-04-24 | 2015-08-05 | 苏州固基电子科技有限公司 | Intravascular stent |
| CN106580516A (en) * | 2016-11-28 | 2017-04-26 | 上海市徐汇区大华医院 | Degradable biliary duct drug-eluting stent |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
| CN1899222A (en) * | 2005-07-21 | 2007-01-24 | 西门子公司 | Implant, apparatus and method for determining position of implant in body |
| CN102596277A (en) * | 2009-07-09 | 2012-07-18 | 麦德托尼克瓦斯科尔勒公司 | Hollow tubular drug eluting medical devices |
| CN102596279A (en) * | 2009-09-20 | 2012-07-18 | 麦德托尼克瓦斯科尔勒公司 | Method of forming hollow tubular drug eluting medical devices |
| CN203425069U (en) * | 2013-06-17 | 2014-02-12 | 苏州爱瑞德医疗科技有限公司 | Targeted drug delivery tube woven intravascular stent |
-
2013
- 2013-06-17 CN CN2013102396028A patent/CN103315833A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
| CN1899222A (en) * | 2005-07-21 | 2007-01-24 | 西门子公司 | Implant, apparatus and method for determining position of implant in body |
| CN102596277A (en) * | 2009-07-09 | 2012-07-18 | 麦德托尼克瓦斯科尔勒公司 | Hollow tubular drug eluting medical devices |
| CN102596279A (en) * | 2009-09-20 | 2012-07-18 | 麦德托尼克瓦斯科尔勒公司 | Method of forming hollow tubular drug eluting medical devices |
| CN203425069U (en) * | 2013-06-17 | 2014-02-12 | 苏州爱瑞德医疗科技有限公司 | Targeted drug delivery tube woven intravascular stent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104814818A (en) * | 2015-04-24 | 2015-08-05 | 苏州固基电子科技有限公司 | Intravascular stent |
| CN106580516A (en) * | 2016-11-28 | 2017-04-26 | 上海市徐汇区大华医院 | Degradable biliary duct drug-eluting stent |
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Application publication date: 20130925 |
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