CN103308458A - System for online detection of drug extracts through hollow fiber - Google Patents
System for online detection of drug extracts through hollow fiber Download PDFInfo
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- CN103308458A CN103308458A CN2013102025954A CN201310202595A CN103308458A CN 103308458 A CN103308458 A CN 103308458A CN 2013102025954 A CN2013102025954 A CN 2013102025954A CN 201310202595 A CN201310202595 A CN 201310202595A CN 103308458 A CN103308458 A CN 103308458A
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- optic fibre
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Abstract
The invention discloses a system for online detection of drug extracts through a hollow fiber. The system comprises a dark box, a hollow fiber, a high-voltage power supply, a laser light source, a scanning motor, a feed screw nut drive mechanism, a spectrum acquisition unit and a spectrum analysis system, wherein the hollow fiber is arranged in the dark box; two poles of the high-voltage power supply are respectively connected to two ends, in the dark box, of the hollow fiber; light beams of the laser light source are emitted into the hollow fiber from one exit end of the hollow fiber; the scanning motor and the feed screw nut drive mechanism are arranged in the dark box; the spectrum acquisition unit is mounted on the feed screw nut drive mechanism and is in signal connection with the spectrum analysis system. According to the system, the laser light beams conducted by the hollow fiber and the electrophoresis of a high-voltage electric field are conducted so as to separate the drug extracts, and spectral signals at each site are fast recorded by the spectrum acquisition unit and are transmitted to the spectrum analysis system to be analyzed so as to rapidly determine each component at each site of the hollow fiber, so that the working efficiency is improved, and the workload is reduced.
Description
Technical field
The present invention relates to the drug line detection system, particularly the online detection of drugs of a kind of hollow-core fiber is extracted into subsystem.
Background technology
Along with the development of modern science and technology, Chinese medicine production also is faced with the task of how to realize controlledization.The mode of production of traditional Chinese medicine is leaned on the quality of stablizing to control product of experience and process conditions basically, the control randomness is larger, so that being grouped into content, the one-tenth in the final products differs larger, affect drug effect, be badly in need of improving by the means of modern science and technology the quality control level of Chinese Traditional Medicine.Because Chinese medicine itself is the multicomponent mixture of a complexity, the various but quantity of contained chemical classes seldom, and active principle is indefinite so that the control of common off-line analysis is all very difficult, the online detection especially is difficult for.
In medicine extracts or analyzes, variation to each composition detects analysis, is one and makes all medicines extract one of the most time-consuming process of Separation Research developers, in the prior art, method mainly contains the HPLC high pressure liquid phase analysis at present, gas phase analysis, mass spectrophotometry etc., but these detection methods need long detection time, and the testing amount is large, complex operation reduces work efficiency, seems particularly important so how the express-analysis composition changes.
In sum, for shortcomings and deficiencies of the prior art, need especially a kind of system that can fast and accurately detect online medicine extraction composition, to address the above problem.
Summary of the invention
The object of the present invention is to provide the online detection of drugs of a kind of hollow-core fiber to be extracted into subsystem, this hollow-core fiber on-line quick detection medicine is extracted into subsystem can fast and accurately detect medicine extraction composition online, greatly improve work efficiency, reduced workload.
Technical matters solved by the invention can realize by the following technical solutions:
The online detection of drugs of hollow-core fiber is extracted into subsystem, it is characterized in that, comprising:
One camera bellows;
One is arranged on the hollow optic fibre in the described camera bellows, and described camera bellows is extended at the two ends of described hollow optic fibre, and described hollow optic fibre consists of the passage of drug extract, and its two ends of extending camera bellows are respectively the entrance and exit of drug extract;
One high-voltage power supply, the two poles of the earth of described high-voltage power supply are connected to the two ends that described hollow optic fibre is positioned at described camera bellows;
One LASER Light Source, the light beam of described LASER Light Source enters described hollow optic fibre from outlet one end-fire of described hollow optic fibre;
One scan motor, described scan module are arranged in the described camera bellows;
One screw nut driving mechanism, the screw mandrel in the described screw nut driving mechanism is connected with the output shaft of described scan module;
One is installed in the spectra collection unit on the nut of described screw nut driving mechanism, and the nut that follow in the screw nut driving mechanism this spectra collection unit moves around along screw mandrel, and the spectrum that described hollow optic fibre is sent scans;
One spectroscopic analysis system, described spectra collection unit is connected with described spectroscopic analysis system signal, and the spectral signal input spectrum analytic system that gathers is analyzed.
In a preferred embodiment of the present invention, described spectra collection unit comprises ccd image sensor and light path, and described ccd image sensor is connected with the input end of described light path, and the output terminal of light path is connected with described spectroscopic analysis system.
In a preferred embodiment of the present invention, described light path is the filtering light path, is provided with the filter disc for filtering on the described filtering light path.
Owing to having adopted technical scheme as above, beneficial effect of the present invention is: when detection liquid is flowed through hollow-core fiber, hollow-core fiber is as the passage of high voltage swimming lane and light beam conduction, detecting liquid separates in hollow-core fiber and under the effect of electric field electrophoresis fast, pass into simultaneously laser, laser conducts in hollow-core fiber, separate drug in the hollow-core fiber is under laser excitation, each composition is subject to exciting of laser, can produce different fluorescence and Raman spectrum, the spectrum of the detection liquid various piece in the spectra collection unit in the hollow-core fiber outside can the sweep record hollow-core fiber, carry out spectral analysis or spectral instrument demodulation analysis, can record corresponding spectral signal, and then each composition in the record analysis swimming lane fast and accurately, greatly improve work efficiency, reduced workload.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art, the below will do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art, apparently, accompanying drawing in the following describes only is some embodiments of the present invention, for those of ordinary skills, under the prerequisite of not paying creative work, can also obtain according to these accompanying drawings other accompanying drawing.
Fig. 1 is the structural representation of an embodiment of the present invention.
Embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, below in conjunction with concrete diagram, further set forth the present invention.
Referring to shown in Figure 1, the online detection of drugs of hollow-core fiber is extracted into subsystem and comprises camera bellows 500, hollow-core fiber 100, high-voltage power supply 300, LASER Light Source 200, spectroscopic analysis system 400, scan module 420, spectra collection unit 410 and screw nut driving mechanism 700, hollow-core fiber 100 is arranged in the camera bellows 500, camera bellows 500 is extended at the two ends of hollow optic fibre 100, hollow optic fibre 100 consists of the passage of drug extract, its two ends of extending camera bellows 500 are respectively entrance 1 and the outlet 2 of drug extract, two electrodes 310 of high-voltage power supply 300,320 respectively by wire 311,312 are connected to the two ends that hollow-core fiber 100 is positioned at camera bellows 500, scan module 420 is arranged on camera bellows 500, guarantee that whole working environment can not be subject to the impact of extraneous light, improve precision of analysis.
Screw nut driving mechanism 700 comprise screw mandrel 710 and with the nut 720 that is spun on the leading screw 710, screw mandrel 710 is connected with the output shaft of scan module 420, spectra collection unit 410 is installed on the nut 720, the nut 720 that follow in the screw nut driving mechanism 700 spectra collection unit 410 moves around along screw mandrel 710, the spectrum that hollow optic fibre 100 is sent scans, spectra collection unit 410 is connected with spectroscopic analysis system 400 signals, and the spectral signal input spectrum analytic system 400 that gathers is analyzed.In the present embodiment, spectra collection unit 410 comprises ccd image sensor and filtering light path, is provided with the filter disc for filtering on the filtering light path, and ccd image sensor is connected with the input end of light path, and the output terminal of light path is connected 400 with spectroscopic analysis system.
Principle of work of the present invention is as follows:
Hollow-core fiber 100 of the present invention has multi-functional, both can be used as the Transfer pipe that detects liquid 600, can be used as again the high voltage swimming lane of high-voltage power supply 300, also can be used as the light beam conduction pathway of LASER Light Source 200, so that compact conformation of the present invention.
During work, start LASER Light Source 200 and high-voltage power supply 300, when detection liquid 600 is flowed through hollow-core fiber 100, detecting liquid 600 separates in hollow-core fiber 100 and under the electric field electrophoretic action of high-voltage power supply 300 fast, LASER Light Source 200 passes into laser simultaneously, laser conducts in hollow-core fiber 100, detect under the laser excitation of medicine in hollow-core fiber 100 that separates in the liquid 600, each composition is subject to exciting of laser, can produce different fluorescence and Raman spectrum, this moment detection liquid 600 various pieces in the spectra collection unit 410 in hollow-core fiber 100 outsides can sweep record hollow-core fiber 100 spectrum and send spectroscopic analysis system 400 to and carry out spectral analysis or spectral instrument demodulation analysis, record corresponding spectral signal, and then detection liquid 600 each compositions in the record analysis hollow-core fiber 100 fast and accurately, greatly improve work efficiency, reduced workload.
Above demonstration and described ultimate principle of the present invention and principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; that describes in above-described embodiment and the instructions just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (3)
1. the online detection of drugs of hollow-core fiber is extracted into subsystem, it is characterized in that, comprising:
One camera bellows;
One is arranged on the hollow optic fibre in the described camera bellows, and described camera bellows is extended at the two ends of described hollow optic fibre, and described hollow optic fibre consists of the passage of drug extract, and its two ends of extending camera bellows are respectively the entrance and exit of drug extract;
One high-voltage power supply, the two poles of the earth of described high-voltage power supply are connected to the two ends that described hollow optic fibre is positioned at described camera bellows;
One LASER Light Source, the light beam of described LASER Light Source enters described hollow optic fibre from outlet one end-fire of described hollow optic fibre;
One scan motor, described scan module are arranged in the described camera bellows;
One screw nut driving mechanism, the screw mandrel in the described screw nut driving mechanism is connected with the output shaft of described scan module;
One is installed in the spectra collection unit on the nut of described screw nut driving mechanism, and the nut that follow in the screw nut driving mechanism this spectra collection unit moves around along screw mandrel, and the spectrum that described hollow optic fibre is sent scans;
One spectroscopic analysis system, described spectra collection unit is connected with described spectroscopic analysis system signal, and the spectral signal input spectrum analytic system that gathers is analyzed.
2. the online detection of drugs of hollow-core fiber as claimed in claim 1 is extracted into subsystem, it is characterized in that, described spectra collection unit comprises ccd image sensor and light path, and described ccd image sensor is connected with the input end of described light path, and the output terminal of light path is connected with described spectroscopic analysis system.
3. the online detection of drugs of hollow-core fiber as claimed in claim 2 is extracted into subsystem, it is characterized in that, described light path is the filtering light path, is provided with the filter disc for filtering on the described filtering light path.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310202595.4A CN103308458B (en) | 2013-05-27 | 2013-05-27 | System for online detection of drug extracts through hollow fiber |
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| CN201310202595.4A CN103308458B (en) | 2013-05-27 | 2013-05-27 | System for online detection of drug extracts through hollow fiber |
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| CN103308458A true CN103308458A (en) | 2013-09-18 |
| CN103308458B CN103308458B (en) | 2016-08-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103888526A (en) * | 2014-03-13 | 2014-06-25 | 无锡香象生物科技有限公司 | Frequency stabilization laser detection drug and food genetic map management system based on internet of things |
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| CN102023132A (en) * | 2010-11-02 | 2011-04-20 | 吉林大学 | Gas-sensitive absorption device based on hollow optical fibre |
| JP2012242311A (en) * | 2011-05-23 | 2012-12-10 | Mitsubishi Electric Corp | Gas analyzer |
| CN102879365A (en) * | 2012-09-21 | 2013-01-16 | 常州大学 | Capillary electrophoresis fluorescence detection device |
| CN203365325U (en) * | 2013-05-27 | 2013-12-25 | 上海远跃制药机械股份有限公司 | Online drug extraction ingredient detecting system adopting hollow-core fiber |
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2013
- 2013-05-27 CN CN201310202595.4A patent/CN103308458B/en active Active
Patent Citations (8)
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| JP2001513350A (en) * | 1997-08-09 | 2001-09-04 | ロシュ ダイアグノスティックス ゲーエムベーハー | Analytical device for in vivo analysis in a patient's body |
| US6584335B1 (en) * | 1997-08-09 | 2003-06-24 | Roche Diagnostics Gmbh | Analytical device for in vivo analysis in the body of a patient |
| JP2002340900A (en) * | 2001-05-18 | 2002-11-27 | Mitsubishi Rayon Co Ltd | Biosensor, biosensor array, and detection method |
| CN1563670A (en) * | 2004-04-02 | 2005-01-12 | 清华大学 | Oil and water content and profile fiber sensor |
| CN102023132A (en) * | 2010-11-02 | 2011-04-20 | 吉林大学 | Gas-sensitive absorption device based on hollow optical fibre |
| JP2012242311A (en) * | 2011-05-23 | 2012-12-10 | Mitsubishi Electric Corp | Gas analyzer |
| CN102879365A (en) * | 2012-09-21 | 2013-01-16 | 常州大学 | Capillary electrophoresis fluorescence detection device |
| CN203365325U (en) * | 2013-05-27 | 2013-12-25 | 上海远跃制药机械股份有限公司 | Online drug extraction ingredient detecting system adopting hollow-core fiber |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103888526A (en) * | 2014-03-13 | 2014-06-25 | 无锡香象生物科技有限公司 | Frequency stabilization laser detection drug and food genetic map management system based on internet of things |
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Address after: Liantang Town Qingpu District Shanghai city 201716 steamed Xia Lu No. 328 Applicant after: SHANGHAI UNIWIN PHARMACEUTICAL MACHINERY CO., LTD. Address before: Liantang Town Qingpu District Shanghai city 201716 steamed Xia Lu No. 328 Applicant before: Shanghai Uniwin Pharmaceutical Machinery Co., Ltd. |
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