CN103300938A - Trans-atrial pathway atrioventricular valve regurgitation animal modeling device and method - Google Patents
Trans-atrial pathway atrioventricular valve regurgitation animal modeling device and method Download PDFInfo
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- CN103300938A CN103300938A CN2013102616390A CN201310261639A CN103300938A CN 103300938 A CN103300938 A CN 103300938A CN 2013102616390 A CN2013102616390 A CN 2013102616390A CN 201310261639 A CN201310261639 A CN 201310261639A CN 103300938 A CN103300938 A CN 103300938A
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Abstract
The invention provides a trans-atrial pathway atrioventricular valve regurgitation animal modeling device. The device comprises a cutting rod for cutting a valve and an outer sleeve (2) with a sealed communicating pipe, wherein the outer sleeve (2) with the sealed communicating pipe comprises a communicating pipe (7) and a hollow metal pipe (8) which are communicated in a sealed manner; the cutting rod (1) is mounted in the hollow metal pipe (8) in a matched manner. The invention also discloses a trans-atrial pathway atrioventricular valve regurgitation animal modeling method. The trans-atrial pathway atrioventricular valve regurgitation animal modeling device provided by the invention have the advantages of simplicity and convenience in operation, easiness in use, low cost, easily controllable regurgitation amount, high modeling rate and no X-ray radiation risk, can achieve accurate positioning of valve leaflets, and has a wide application range.
Description
Technical field
The present invention relates to the device and method that animal disease model is made, especially a kind of producing device and method for large animal chamber valve reflux disease model.
Background technology
Valvular regurgitation is a kind of clinical common cardiac disorder, wherein common clinically with mitral incompetence (mitral regurgitation, MR), it is reported, the ultrasonic examination mild MR can be up to 19% at normal population, and moderate MR or severe MR are respectively 1.9% and 0.2%.Mitral incompetence can cause that pulmonary vein and pulmonary capillary pressure raise, and cause vasodilation and congestion then so that left atrium and left ventricular diastolic load increase the weight of; The left ventricular diastolic volume load increases simultaneously, and left ventricle enlarges, if acute serious mitral incompetence can make left atrium and pulmonary vein pressure sharply rise, causes acute lung edema.Chronic MR harm is also large, and untimely diagnosis and treatment also often cause pulmonary venous pleonaemia and body circumfusion to hang down inferior left heart failure easy atrial fibrillation, and pulmonary hypertension and whole heart failure can appear in late period, directly life-threatening.Just because of this, the clinical importance of MR is subject to increasing attention, research about mechanism, Pathophysiology characteristics and the diagnosis and treatment new technique of MR is extensively carried out, the video diagnostic technology that some are new, especially the genesis change mechanism of atrial fibrillation, study hotspot all needs a good stable MR large animal model in the fields such as the medical and surgical treatment means evaluation of heart failure.
Setting up at present this class animal model mainly reaches by the primary structure that destroys, changes or affect the Bicuspid valve devices such as lobe leaf, chordae tendineae, papillary muscles, lobe ring, left atrium or left ventricle and affects the valve tight closure, thereby cause blood from the anti-atrium that flows to of ventricle, reach the purpose of making chamber valvular regurgitation large animal model.Wherein the most easily realize by damage lobe leaf and chordae tendineae.Make by this method animal valvular regurgitation model two approach are arranged: open breast and do not open breast.The method of traditional making mitral incompetence model of opening breast generally needs to destroy valve or chordae tendineae through left auricle operation cut-out by extracorporeal circulation under direct-view, and the model that these class methods are made is homogeneous comparatively, and is definite, but expense is higher, and wound is larger; Also have and see the die-manufacturing method that through the apex position Bicuspid valve is damaged under a kind of beating heart, this method similar technology difficulty is large, and wound is still larger.The method master who does not open breast refers to by the conduit interventional technique under the guidance of X-ray, destroy valve or chordae tendineae by special nipper, this method generally need to be by the anti-size that flows of ultrasonic judgement, owing to needing special nipper under X-ray, to operate, specification requirement is higher, difficulty is large, cost is high, long also poor apart from the controllability of operation model, often or pull too heavyly, mortality rate is very high, or pulls lighter, the inadequate homogeneous of model, operate comparatively loaded down with trivial details, it is poor that model can repeat, often need repeatedly injection of contrast medium, consumptive material is expensive, and the modelling personnel need be exposed under the x-ray, so that the practical application of this method is subject to certain limitation, the foundation of mitral incompetence model once had been trapped in bottleneck stage.
From the above mentioned, there is following deficiency in the anti-fluid disease model of existing chamber valve mold making technology: the traditional surgery wound is larger, the animal easy infection, and mortality of animals is high, and is costly; Get involved the method for not opening breast under the x-ray and need special molding instrument, operate loaded down with trivial details, technical difficulty large, be difficult for grasping anti-uninterrupted, modelling repeatable poor, mortality rate is high, the model homogeneity is poor, often need repeatedly injection of contrast medium, consumptive material is expensive, modelling personnel and animal all need be exposed to heavy dose of roentgen radiation x, so that its scope of application is limited.
Summary of the invention
In order to overcome above-mentioned technical problem, the objective of the invention is for the anti-fluid disease model of present chamber valve in the urgent need to, the wound of tradition disease model surgery preparation method is large, easily send out and infect, mortality of animals is high, costly shortcoming provides a kind of through the anti-fluid modelling of atrium approach chamber valve device.
Another object of the present invention provides a kind of method through the anti-fluid modelling of atrium approach chamber valve.
To achieve these goals, of the present invention a kind of through the anti-fluid modelling of atrium approach chamber valve device, comprise for the cutter bar that cuts valve and the trocar sheath of band sealing communicating pipe, wherein:
The trocar sheath of described band sealing communicating pipe comprises communicating pipe and hollow metal pipe;
Described communicating pipe and the hollow metal seal of tube are communicated with;
Described cutter bar is supporting to be installed in the hollow metal bar.
Described cutter bar comprises the cutting barb that Metallic rod is connected with the Metallic rod bottom.
Described cutter bar also comprises hand-held external member, and hand-held external member is fixedly connected on the other end of Metallic rod.
The trocar sheath of described band sealing communicating pipe also comprises seal header joints; Wherein:
Described seal header joints is provided with sealing circular hole and side seal connecting hole;
Described hollow metal pipe is tightly connected with the sealing circular hole;
Described communicating pipe and side seal connecting hole are tightly connected.
The trocar sheath of described band sealing communicating pipe also comprises valve, and the other end of valve and communicating pipe is tightly connected.
A kind of through the anti-fluid model production method of atrium approach chamber valve, comprise the steps:
1) opens breast at the little otch of 2-3 intercostal through the animal of art pre-treatment, cut pericardium, the trocar sheath of band sealing communicating pipe is inserted a left side or right auricle, enter a left side or right atrium, continue deeply to pass mitral valve;
2) hollow metal pipe when the trocar sheath of being with sealing communicating pipe passes PM, and cutter bar is passed hollow metal pipe, makes cutter bar tangle valvular tissue, back withdraws from cutter bar again.
Described step 2) cutter bar passes hollow metal pipe in after the sealing circular hole inserts, and makes the cutting barb of cutter bar tangle valvular tissue, back withdraws from cutter bar again.
Advantage through the anti-fluid modelling of atrium approach chamber valve device and method of the present invention is:
1. use little otch to make animal chamber valvular regurgitation model manipulation through the anti-fluid modelling of atrium atrioventricular valves (A V valves) film device simple, be easy to use, can realize mini-invasive incision, heart need not to stop jumping, but need not extracorporeal circulation, anti-flow sxemiquantitative control, can accurately navigate to the lobe leaf of intending destruction, become the mould rate high.
2. use the valve shearing device to make animal valvular regurgitation model and need not to use x-ray imaging, without x-ray radiation is dangerous, cost is low, be easy to popularization, can extensively use.
Description of drawings
Fig. 1 is an embodiment of the present invention front view.
Fig. 2 is cutter bar front view in an embodiment of the present invention.
Fig. 3 is the trocar sheath front view of band sealing communicating pipe in an embodiment of the present invention.
The specific embodiment
Below with reference to accompanying drawing embodiments of the invention are described.The element of describing in an accompanying drawing of the present invention or a kind of embodiment and feature can combine with element and the feature shown in one or more other accompanying drawings or the embodiment.Should be noted that for purpose clearly, omitted expression and the description of parts that have nothing to do with the present invention, known to persons of ordinary skill in the art or processing in accompanying drawing and the explanation.
Below in conjunction with accompanying drawing the present invention is described further.
Fig. 1 is an embodiment of the present invention front view, as shown in fig. 1, of the present invention a kind of through the anti-fluid modelling of atrium approach chamber valve device, comprise for the cutter bar 1 that cuts valve and the trocar sheath 2 of band sealing communicating pipe, wherein: the trocar sheath 2 of described band sealing communicating pipe comprises communicating pipe 7 and hollow metal pipe 8; Communicating pipe 7 and hollow metal pipe 8 sealings are communicated with.
Fig. 2 is cutter bar front view in an embodiment of the present invention, as shown in Figure 2, described cutter bar 1 comprises that Metallic rod 4, cutting barb 5, hand-held external member 3 consist of, and Metallic rod 4 one ends are provided with cutting barb 5, and hand-held external member 3 is fixedly connected on the other end of Metallic rod 4.Wherein, described hand-held external member 3 is made by plastic material, with the stricture of vagina road of being convenient to grip or grip; Described Metallic rod 4 is made by the intensity rustless metal, and diameter is not more than band trocar sheath 2 internal diameters of sealing communicating pipe, is preferably 3mm; Length slightly is longer than the band trocar sheath 2 of sealing communicating pipe, preferred 20cm; Described cutting barb 5 is " L " hook scraper shape, and its cross section is no more than Metallic rod place cross section.
Fig. 3 is the trocar sheath front view of band sealing communicating pipe in an embodiment of the present invention, and as shown in Figure 3, the trocar sheath 2 of described band sealing communicating pipe comprises seal header joints 6, communicating pipe 7, hollow metal pipe 8, three-way valve 11; Wherein: described seal header joints 6 is provided with sealing circular hole 9 and side seal connecting hole 10; Hollow metal pipe 8 is tightly connected with sealing circular hole 9; Communicating pipe 7 is tightly connected with side seal connecting hole 10; , three-way valve 11 is tightly connected with the other end of communicating pipe 7.
Wherein, described seal header joints 6 is that a short cylindrical, hollow plastic material is made, described sealing circular hole 9 centers of circle and the hollow metal pipe 8 cross section centers of circle are on same straight line, the diameter of sealing circular hole 9 is identical in hollow metal pipe 8, and described hollow metal pipe 8 is made by the stainless hollow metal of intensity, and diameter is greater than Metallic rod 4, preferred internal diameter is 3.5mm, preferred external diameter is 4mm, and length is less than Metallic rod 4, and preferred diameter is 15cm; Described communicating pipe 7 makes for the plastic hollow flexible pipe, and an end is connected in seal header joints 6, and the other end is connected with three-way valve 11.
Of the present inventionly through the atrium anti-fluid model production method of approach chamber valve be:
Before the use, to treat first the conventional anesthesia of animal of molding, tracheal intubation, set up venous channel, if set up the anti-flow model of left side chamber valve, the animal right arm reclining, the little otch of 2-3 intercostal is opened breast, cut pericardium, at the left auricle pocket of sewing it up, the trocar sheath 2 of band sealing communicating pipe is inserted left auricle through the good pocket of pre-stitching, enter left room, continue deeply will pass mitral valve, can judge whether hollow metal pipe 8 enters ventricle this moment by the speed emergency of the blood that flows out communicating pipe 7, when entering, hollow metal tube 8 passes PM, taking out cutter bar 1 inserts through the sealing circular hole 9 of seal header joints 6, pass hollow metal pipe 8, after barb 5 to be cut stretches out from hollow metal pipe 8, can sound out toward withdrawing, slightly firmly back withdraw from cutter bar 1 after sensation cutting barb 5 tangles valvular tissue, can cut off valve this moment, finishes the molding operation, the anti-fluid disease model of other chamber valves can be with reference to mitral incompetence animal disease model manufacture method analogue formation, by the equipment such as ultrasonic machine can the Real Time Observation molding successful situation.
The present invention is simple to operation, is easy to use, and cost is low, and anti-flow easy-control becomes the mould rate high, and is dangerous without x-ray radiation, is a kind ofly can accurately locate the lobe leaf, the special-purpose valvular regurgitation animal disease model producing device that the utilization scope is wide.
Although described the present invention and advantage thereof in detail, be to be understood that and in the situation that does not exceed the spirit and scope of the present invention that limited by appended claim, can carry out various changes, alternative and conversion.And the application's scope is not limited only to the specific embodiment of the described process of description, equipment, means, method and step.The one of ordinary skilled in the art will readily appreciate that from disclosure of the present invention, can use according to the present invention carry out with the essentially identical function of corresponding embodiment described herein or obtain result essentially identical with it, existing and want exploited process, equipment, means, method or step future.Therefore, appended claim is intended to comprise such process, equipment, means, method or step in their scope.
Claims (7)
1. one kind through the anti-fluid modelling of atrium approach chamber valve device, it is characterized in that: comprise the trocar sheath (2) that seals communicating pipe for the cutter bar (1) that cuts valve and band, wherein:
The trocar sheath (2) of described band sealing communicating pipe comprises communicating pipe (7) and hollow metal pipe (8);
Described communicating pipe (7) and hollow metal pipe (8) sealing are communicated with;
Described cutter bar (1) is supporting to be installed in the hollow metal bar (8).
2. according to claim 1 through the anti-fluid modelling of atrium approach chamber valve device, it is characterized in that: described cutter bar (1) comprises that Metallic rod (4) is connected 4 with Metallic rod) the cutting barb (5) that connects of bottom.
3. according to claim 1 and 2 it is characterized in that: described cutter bar (1) also comprises hand-held external member (3) through the anti-fluid modelling of atrium approach chamber valve device, and hand-held external member (3) is fixedly connected on the other end of Metallic rod (4).
4. according to claim 1 through the anti-fluid modelling of atrium approach chamber valve device, it is characterized in that: the trocar sheath (2) of described band sealing communicating pipe also comprises seal header joints (6); Wherein:
Described seal header joints (6) is provided with sealing circular hole (9) and side seal connecting hole (10);
Described hollow metal pipe (8) is tightly connected with sealing circular hole (9);
Described communicating pipe (7) is tightly connected with side seal connecting hole (10).
5. according to claim 1 or 4 described through the anti-fluid modelling of atrium approach chamber valve device, it is characterized in that: the trocar sheath (2) of described band sealing communicating pipe also comprises valve (11), and valve (11) is tightly connected with the other end of communicating pipe (7).
6. one kind through the anti-fluid model production method of atrium approach chamber valve, adopts claim 1-5 any one described through the anti-fluid modelling of atrium approach chamber valve device, it is characterized in that comprising the steps:
1) opens breast at the little otch of 2-3 intercostal through the animal of art pre-treatment, cut pericardium, the trocar sheath (2) of band sealing communicating pipe is inserted a left side or right auricle, enter a left side or right atrium, continue deeply to pass mitral valve;
2) hollow metal pipe (8) when the trocar sheath (2) of being with sealing communicating pipe passes PM, and cutter bar (1) is passed hollow metal pipe (8), makes cutter bar (1) tangle valvular tissue, back withdraws from cutter bar (1) again.
7. according to claim 6 a kind of through the anti-fluid model production method of atrium approach chamber valve, it is characterized in that:
Described step 2) cutter bar (1) passes hollow metal pipe (8) in after sealing circular hole (9) inserts, and makes the cutting barb (5) of cutter bar (1) tangle valvular tissue, back withdraws from cutter bar (1) again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310261639.0A CN103300938B (en) | 2013-06-27 | 2013-06-27 | Trans-atrial pathway atrioventricular valve regurgitation animal modeling device |
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| CN201310261639.0A CN103300938B (en) | 2013-06-27 | 2013-06-27 | Trans-atrial pathway atrioventricular valve regurgitation animal modeling device |
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| CN103300938A true CN103300938A (en) | 2013-09-18 |
| CN103300938B CN103300938B (en) | 2015-05-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403249A (en) * | 2018-01-24 | 2018-08-17 | 四川省人民医院 | A kind of aortic incompetence animal model making device |
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| CN108403249A (en) * | 2018-01-24 | 2018-08-17 | 四川省人民医院 | A kind of aortic incompetence animal model making device |
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| CN103300938B (en) | 2015-05-20 |
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