CN103217324A - Biochip sample application instrument - Google Patents
Biochip sample application instrument Download PDFInfo
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- CN103217324A CN103217324A CN2013101228557A CN201310122855A CN103217324A CN 103217324 A CN103217324 A CN 103217324A CN 2013101228557 A CN2013101228557 A CN 2013101228557A CN 201310122855 A CN201310122855 A CN 201310122855A CN 103217324 A CN103217324 A CN 103217324A
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- syringe needle
- plc controller
- sample application
- travelling mechanism
- electric pump
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Abstract
The invention provides a biochip sample application instrument. The technical scheme is as follows: the biochip sample application instrument comprises a bracket, wherein the bracket is provided with an X-directional operation mechanism with a servo motor, a Y-directional operation mechanism and a Z-directional operation mechanism; the Z-directional operation mechanism is provided with a needle head fixing seat with a needle head; the bracket is provided with a sample application platform; and the bracket at one side of the sample application platform is provided with a sample box fixing seat, an ultrasonic washing and drying box and an electronic stroboscopic shooting device. The sample application instrument disclosed by the scheme can accurately finish sample application; and the needle head can be rapidly and conveniently washed and dried.
Description
Technical field
What the present invention relates to is a kind of point sample instrument that is used for biochip.
Background technology
In the prior art, technique known is that biochip is at new drug development, field such as medical diagnosis on disease and clinical monitoring is widely used, point sample instrument is exactly to be used for micro-biological sample is transferred to the device that forms microarray on the carrier of biochip according to predetermined mode, present point sample instrument directly is laid in the biochip carrier on the sample application platform mostly, between carrier and platform, can produce relatively like this and slide, and, part carrier (as cellulose membrane) itself has static, can produce little projection after the tiling, influence the effect of point sample, when cleaning syringe needle, syringe needle is stretched in the cleaning box, clean, because the flow velocity of water is limited by flowing freely of water in the cleaning box to syringe needle, can not clean completely to syringe needle, this is the existing in prior technology weak point.
Summary of the invention
Purpose of the present invention is exactly at the existing in prior technology deficiency, and a kind of technical scheme of biochip point sample instrument is provided, and the point sample instrument of this scheme can be finished point sample accurately, to syringe needle clean quickly and easily, drying.
This programme is realized by following technical measures: a kind of biochip point sample instrument, comprise support, described support be provided with the X that has servomotor to travelling mechanism, Y to travelling mechanism and Z to travelling mechanism, the characteristics of this programme are: described Z is provided with the syringe needle holder that has syringe needle to travelling mechanism, described support is provided with sample application platform, and the support of sample application platform one side is provided with sample box holder, ultrasonic cleaning drying box and electronic stroboscopic camera arrangement.
Described sample application platform comprises the paralell that is fixed on the support, and the paralell top is fixed with panel, and described panel is provided with a plurality of holes, is provided with cavity between described panel and the paralell, has an air pump to be communicated with cavity by pipeline.
Described electronic stroboscopic camera arrangement is connected with a PLC controller, described PLC controller is connected with described servomotor, described PLC controller also is connected with the electric pump case that is used for fixing electric pump, described electric pump case is respectively by pipeline and syringe needle, washer bottle is connected with the waste liquid returnable bottle, described ultrasonic cleaning drying box is connected with the waste liquid returnable bottle by pipeline, described ultrasonic cleaning drying box is connected with the PLC controller, described PLC controller and upper control machine connect, be provided with liquid level sensor in the described washer bottle, described liquid level sensor is connected with described PLC controller, described PLC controller is connected with air pump, also has one to be equipped with the liquid bottle and to be communicated with the electric pump case by pipeline.
Described ultrasonic cleaning drying box comprises cleaning area and dry section, be provided with the syringe needle hole that is used to clean syringe needle in the cleaning area, described syringe needle hole is communicated with the electric pump case, and described syringe needle hole is communicated with the waste liquid returnable bottle, and the box body of described dry section is provided with a plurality of strip grooves.
The beneficial effect of this programme can be learnt according to the narration to such scheme, since in this scheme, have X to travelling mechanism, Y to travelling mechanism and Z to travelling mechanism, Z is provided with the syringe needle holder that has syringe needle to travelling mechanism, can drive syringe needle and carry out titration to the position that configures; A plurality of holes are arranged on the panel of sample application platform, there is an air pump to be communicated with cavity, when panel is laid the biochip carrier, can the air in the cavity be extracted out with air pump and produce negative pressure like this by pipeline, make smooth being layered on the panel of biochip carrier, can not produce bubble; Syringe needle hole and strip groove on the ultrasonic cleaning drying box, can carry out ultrasonic cleaning to syringe needle by the syringe needle hole, the syringe needle hole is communicated with the electric pump case, therefore water flow velocity is fast in the syringe needle hole, just can clean completely in conjunction with ultrasound wave to syringe needle, syringe needle is connected with the electric pump case by pipeline, the electric pump case can supply water to syringe needle, syringe needle inside is cleaned, can be placed dry paper on the strip groove, during dry syringe needle, because strip groove is arranged, disconnected with regard to not bumping syringe needle, provide cost savings to enterprise, can also prevent that the residual liquid of syringe needle end from influencing the point sample effect; The electronic stroboscopic camera arrangement can be taken the dropping liquid situation of syringe needle by electronics, and when having guaranteed point sample, drop evenly drips; The PLC controller is connected with electric pump case, electronic stroboscopic camera arrangement, servomotor etc., carry out control corresponding, the control electric pump supplies water for the ultrasonic cleaning drying box and cleans syringe needle, control electronic stroboscopic camera arrangement is taken pictures to syringe needle, after syringe needle is drawn sample, utilize the electronic stroboscopic lamp that syringe needle is taken pictures, whether the observation sample titration is even, again the biochip carrier carried out point sample after evenly; The PLC controller is also controlled the electric pump in the electric pump case, makes syringe needle draw sample; Be provided with liquid level sensor in the washer bottle, when liquid level was low, liquid level sensor was given the PLC controller signals, and PLC controller control electric pump will be equipped with in the interior liquid suction washer bottle of liquid bottle.This shows that the present invention compared with prior art has outstanding substantive distinguishing features and obvious improvement, the beneficial effect of its enforcement also is conspicuous.
Description of drawings
Fig. 1 is the structural representation of the specific embodiment of the invention.
Fig. 2 be the specific embodiment of the invention the electrical principle block diagram.
Among the figure, 1 is support, and 2 is that X is to travelling mechanism, 3 be Y to travelling mechanism, 4 be Z to travelling mechanism, 5 is the syringe needle holder, 6 is syringe needle, and 7 is the sample box holder, and 8 are the ultrasonic cleaning drying box, 9 is the electronic stroboscopic camera arrangement, 10 is paralell, and 11 is the orbit of Y to travelling mechanism, and 12 is the hole, 13 is air pump, 14 is the electric pump case, and 15 are washer bottle, and 16 for being equipped with the liquid bottle, 17 is liquid level sensor, 18 is cleaning area, and 19 is dry section, and 20 is the waste liquid returnable bottle, 21 is the PLC controller, and 22 is servomotor.
Embodiment
For clearly demonstrating the technical characterstic of this programme,, and, this programme is set forth in conjunction with its accompanying drawing below by an embodiment.
By accompanying drawing as can be seen, the biochip point sample instrument of this programme, comprise support 1, described support 1 be provided with the X that has servomotor 22 to travelling mechanism 2, Y to travelling mechanism 3 and Z to travelling mechanism, described Z is provided with the syringe needle holder 5 that has syringe needle 6 to travelling mechanism 2, described support 1 is provided with sample application platform, and the support 1 of sample application platform one side is provided with sample box holder 7, ultrasonic cleaning drying box 8 and electronic stroboscopic camera arrangement 9.
Described sample application platform comprises the paralell 10 that is fixed on the support 1, paralell 10 tops are fixed with panel, described panel is provided with a plurality of holes 12, be provided with cavity between described panel and the paralell 10, have an air pump 13 to be communicated with cavity by pipeline, when laying the biochip carrier on sample application platform, air pump 13 can siphon away the air in the cavity, produce negative pressure, make smooth being layered on the sample application platform of biochip carrier.
Described electronic stroboscopic camera arrangement 9 is connected with a PLC controller 21, described PLC controller 21 is connected with described servomotor 22, described PLC controller 21 also is connected with the electric pump case 14 that is used for fixing electric pump, described electric pump case 14 is respectively by pipeline and syringe needle 6, washer bottle 15 is connected with waste liquid returnable bottle 20, described ultrasonic cleaning drying box 8 is connected with waste liquid returnable bottle 20 by pipeline, described ultrasonic cleaning drying box 8 is connected with PLC controller 21, when cleaning syringe needle, PLC controller 21 just can be controlled the ultrasonic generator vibration in the ultrasonic cleaning drying box 8, simultaneously, the electric pump that PLC controller 21 is also controlled in the electric pump case 14 supplies water for syringe needle 6 and syringe needle hole, be beneficial to the cleaning of syringe needle 6, described PLC controller 21 connects with upper control machine, be provided with liquid level sensor 17 in the described washer bottle 15, described liquid level sensor 17 is connected with described PLC controller 21, and described PLC controller 21 is connected with air pump 13, also has one to be equipped with liquid bottle 16 and to be communicated with electric pump case 14 by pipeline.
Described ultrasonic cleaning drying box 8 comprises cleaning area 18 and dry section 19, be provided with the syringe needle hole that is used to clean syringe needle 6 in the cleaning area 18, described syringe needle hole is communicated with electric pump case 14, described syringe needle hole is communicated with waste liquid returnable bottle 20, and the box body in described dry 19 districts is provided with a plurality of strip grooves.
The present invention is not limited in above-mentioned embodiment, and the variation that those of ordinary skills make in essential scope of the present invention, remodeling, interpolation or replacement also should belong to protection scope of the present invention.
Claims (4)
1. biochip point sample instrument, comprise support, described support be provided with the X that has servomotor to travelling mechanism, Y to travelling mechanism and Z to travelling mechanism, it is characterized in that: described Z is provided with the syringe needle holder that has syringe needle to travelling mechanism, described support is provided with sample application platform, and the support of sample application platform one side is provided with sample box holder, ultrasonic cleaning drying box and electronic stroboscopic camera arrangement.
2. biochip point sample instrument according to claim 1, it is characterized in that: described sample application platform comprises the paralell that is fixed on the support, the both sides of paralell are provided with the orbit of Y to travelling mechanism, the paralell top is fixed with panel, described panel is provided with a plurality of holes, be provided with cavity between described panel and the paralell, have an air pump to be communicated with cavity by pipeline.
3. biochip point sample instrument according to claim 1 and 2, it is characterized in that: described electronic stroboscopic camera arrangement is connected with a PLC controller, described PLC controller is connected with described servomotor, described PLC controller also is connected with the electric pump case that is used for fixing electric pump, described electric pump case is respectively by pipeline and syringe needle, washer bottle is connected with the waste liquid returnable bottle, described ultrasonic cleaning drying box is connected with the waste liquid returnable bottle by pipeline, described ultrasonic cleaning drying box is connected with the PLC controller, described PLC controller and upper control machine connect, be provided with liquid level sensor in the described washer bottle, described liquid level sensor is connected with described PLC controller, and described PLC controller is connected with air pump.
4. biochip point sample instrument according to claim 3, it is characterized in that: described ultrasonic cleaning drying box comprises cleaning area and dry section, be provided with the syringe needle hole that is used to clean syringe needle in the cleaning area, described syringe needle hole is communicated with the electric pump case, described syringe needle hole is communicated with the waste liquid returnable bottle, and the box body of described dry section is provided with a plurality of strip grooves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310122855.7A CN103217324B (en) | 2013-04-10 | 2013-04-10 | Biochip sample application instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310122855.7A CN103217324B (en) | 2013-04-10 | 2013-04-10 | Biochip sample application instrument |
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| Publication Number | Publication Date |
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| CN103217324A true CN103217324A (en) | 2013-07-24 |
| CN103217324B CN103217324B (en) | 2015-06-17 |
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| CN201310122855.7A Active CN103217324B (en) | 2013-04-10 | 2013-04-10 | Biochip sample application instrument |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103398885A (en) * | 2013-07-31 | 2013-11-20 | 重庆大学 | Sample application device for preparing biological test array |
| CN103712956A (en) * | 2014-01-15 | 2014-04-09 | 中国科学院化学研究所 | Microarray sample application device |
| CN104826673A (en) * | 2015-03-16 | 2015-08-12 | 中国科学院微生物研究所 | Writting-type two-dimensional microfluidic drop arraying device, application and use method thereof |
| CN107478476A (en) * | 2017-07-31 | 2017-12-15 | 成都博奥晶芯生物科技有限公司 | A kind of dish-style chip point sample instrument and its application method |
| CN108931415A (en) * | 2017-05-23 | 2018-12-04 | 北京诚智光辉科技有限公司 | Sectioning cells with wiper mechanism dye all-in-one machine |
| CN111386148A (en) * | 2017-09-05 | 2020-07-07 | 阿雷杰特有限公司 | Method and apparatus for manufacturing and validating printed microarrays |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103398885A (en) * | 2013-07-31 | 2013-11-20 | 重庆大学 | Sample application device for preparing biological test array |
| CN103398885B (en) * | 2013-07-31 | 2015-11-04 | 重庆大学 | A kind of spot sample device for the preparation of biological test |
| CN103712956A (en) * | 2014-01-15 | 2014-04-09 | 中国科学院化学研究所 | Microarray sample application device |
| CN103712956B (en) * | 2014-01-15 | 2016-05-11 | 中国科学院化学研究所 | A kind of microarray spot sample device |
| CN104826673A (en) * | 2015-03-16 | 2015-08-12 | 中国科学院微生物研究所 | Writting-type two-dimensional microfluidic drop arraying device, application and use method thereof |
| CN108931415A (en) * | 2017-05-23 | 2018-12-04 | 北京诚智光辉科技有限公司 | Sectioning cells with wiper mechanism dye all-in-one machine |
| CN107478476A (en) * | 2017-07-31 | 2017-12-15 | 成都博奥晶芯生物科技有限公司 | A kind of dish-style chip point sample instrument and its application method |
| CN111386148A (en) * | 2017-09-05 | 2020-07-07 | 阿雷杰特有限公司 | Method and apparatus for manufacturing and validating printed microarrays |
| US11691433B2 (en) | 2017-09-05 | 2023-07-04 | Arrayjet Limited | Method and device for producing a printed microarray and verifying the same |
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| Publication number | Publication date |
|---|---|
| CN103217324B (en) | 2015-06-17 |
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| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20130724 Assignee: Shanghai Lingang Financial Leasing Co.,Ltd. Assignor: Shanghai Yulong Biotech Co.,Ltd. Contract record no.: X2022980015555 Denomination of invention: A biochip spotter Granted publication date: 20150617 License type: Exclusive License Record date: 20220919 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A biochip spotter Effective date of registration: 20220920 Granted publication date: 20150617 Pledgee: Shanghai Lingang Financial Leasing Co.,Ltd. Pledgor: Shanghai Yulong Biotech Co.,Ltd. Registration number: Y2022980015779 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |