CN103206999B - The measuring method of capsule medicinal powder loading amount - Google Patents
The measuring method of capsule medicinal powder loading amount Download PDFInfo
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- CN103206999B CN103206999B CN201310079040.5A CN201310079040A CN103206999B CN 103206999 B CN103206999 B CN 103206999B CN 201310079040 A CN201310079040 A CN 201310079040A CN 103206999 B CN103206999 B CN 103206999B
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Abstract
The present invention relates to a kind of measuring method of capsule medicinal powder loading amount, it is by putting into the changeable airtight container of volume by capsule, and under the prerequisite of the constancy of volume keeping container, the air pressure of container is changed by filling pressurized air or the mode that vacuumizes, and then make container automatically change volume under the effect of inner and outer air pressure difference, thus calculate the volume of medicinal powder in capsule according to the change of this volume.The method is simple and easy to do, and implementation cost is low.
Description
Technical field
The present invention relates to a kind of measuring method measuring the volume of non-gaseous material, particularly to measure in capsule load the method for its content.
Background technology
At art of pharmaceutical industry, due to the impact of the many factors such as stability and medicinal powder self-characteristic of capsule filling apparatus self, the weight of institute's powder charge powder in it and capsule grain is made in the production run of capsule heavily to there is fluctuation, and for the medicine of disease therapy, the amount of contained drug in unit dose, namely the grain of every capsules is heavy just must be stabilized in a narrower scope, so pharmacy corporation heavily can carry out strict management and control and measurement to the grain of capsule, detect and reject the heavy undesirable defect ware of grain.
At present the method that capsule carries out a remeasurement is mainly utilized to various mechanical balance, electronic balance or utilizes the various weighing-appliances of weight sensor principle to carry out direct weighing measurement, but all there is this many drawback in these modes.The weighing process of various mechanical balance, electronic balance all needs manual hand manipulation, and drawback is: detection speed is slow, inefficiency, complex operation; Cannot realize on-line automatic weighing, can only be used for sampling observation, cannot realize carrying out weighing by grain to capsule, the method, to the heavy monitoring dynamics of capsule grain and limited, still has the heavy undesirable capsule of a lot of grain to be detected.And although the various equipment work efficiency of weight sensor principle that utilizes significantly improves, can realize weighing by grain to capsule, also have its remarkable drawback: equipment is accurate, and cost is very expensive, is unfavorable for promoting at pharmacy corporation; System complex, maintenance difficulties is large, and maintenance cost is high.
Summary of the invention
The object of this invention is to provide a kind of assay method of capsule medicinal powder loading amount, it can measure the content of capsule filling medicinal powder rapidly to batch capsule, and cost is very low.
To achieve these goals, the invention provides a kind of measuring method of capsule medicinal powder loading amount, comprise the following steps:
(a), choose the container of variable volume, inserted by capsule to be measured in this container, the volume of container is also remained on initial value V1 by applying external force by airtight container;
(b), in container, be filled with pressure gas or vacuum pumping carried out to container, until the air pressure in container reaches P1, and the air pressure of capsule to be measured also reaches P1, stops the operation that this fills pressure gas or vacuumizes;
(c), cancel as keeping container volume and to container externally applied forces, container is made to expand under the effect of inner and outer air pressure difference or shrink, until the air pressure in container balances with extraneous, the air pressure namely in container reaches ambient pressure P2, measures the volume V2 of now container;
(d), calculate the volume V of medicinal powder in capsule according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0, wherein, V0 is the volume of capsule housing.
Cancelling container externally applied forces, container is being expanded under the effect of inside and outside differential pressure or in the process of shrinking, the air pressure in capsule also can spill from the gap of capsule shells or enter and change along with gas, until reach ambient pressure P2.Meet the unconverted principle of volume of Boyle's law and fixed substance according to gas volume change, the cumulative volume of capsule shells and medicinal powder can be measured, finally draw the volume of medicinal powder.Whole measuring process completes fast, and is simple and easy to implement.
Further, after step (d), according to the density of the volume V of measured medicinal powder and the medicinal powder of precognition, the weight of medicinal powder can be calculated, with the demand of more realistic application.
Advantage of the present invention is: by input compressed-air or vacuumize the air pressure changing container, and the constancy of volume of container is kept in the process by applying external force, after the air pressure in container reaches certain value, cancel container externally applied forces, container is made automatically to change volume under the effect of inner and outer air pressure difference, calculate the medicinal powder loading amount in capsule according to final volume, the method is simple and easy to do, and implementation cost is low.Weigh compared with screening installation with weight sensor class, the requirement of the method to aspects such as the measure of precision of equipment, the sampling and processing difficulty of signal and anti-interferences is all very low, equipment cost for performing the method also can be lower, and be convenient to safeguard, is beneficial to and promotes the use of at pharmacy corporation.
Embodiment
The present invention makes container inflates or contraction by forming draught head inside and outside the container placing capsule, and its content measured in capsule to be measured is changed according to the volume before and after container, and the volume of air in the housing volume of the volume of medicinal powder and capsule to be measured and container inside and outside capsule forms the volume of container jointly, the present invention mainly utilizes gas volume change to meet Boyle's law and obtains principle to calculate the volume of air inside and outside capsule, thus records the medicinal powder volume in capsule according to formula.Below in conjunction with several embodiment, content of the present invention is described in detail.
Embodiment one:
Choose the changeable container of volume, container such as, have at least part wall be flexible, or cylinder etc.Capsule to be measured is put into container, airtight container, and by the mode such as back up pad or fixed mount, the volume of container is first remained on initial value V1.
In container, pass into pressurized air, make the air pressure in container increase gradually, pressurized air can enter capsule by the gap on capsule housing, and thus the air pressure of capsule also can rise gradually, until the air pressure in container reaches P1, stops inflation.
Remove the means for keeping its container be applied on container, container meeting automatic expansion, drop to equal with ambient pressure to its air pressure inside, i.e. P2, now, the volume of container can increase to V2.
According to Boyle's law: P1 (V1-V0-V)=P2 (V2-V0-V), wherein, V0 is the volume of the capsule housing learnt in advance itself, V represents the volume of medicinal powder in capsule, can draw thus: volume V=(P2*V2-P1*V1)/(P2-P1)-V0 of medicinal powder in capsule, then according to the density of institute's powder charge powder in capsule, the weight of medicinal powder can be calculated further.
Because method involved in the present invention is used to measure medicinal powder loading amount in capsule, in container, be filled with compressed-air actuated object is to make the pressure increase in container make container produce volume change under inside and outside differential pressure, instead of in order to make capsule explosion split, therefore, be filled with pressurized air without the need to a lot, without the need to reaching usual so-called definitely " high pressure " state of those skilled in the art in container, be filled with compressed-air actuated speed also without the need to very fast.Or, carry out spacing to capsule in container, split to prevent capsule overexpansion, in this case, the compressed-air actuated amount that is filled with can not be limited, that is, can make to reach high pressure conditions in container.
Embodiment two:
Similar to embodiment one, first should choose the changeable container of volume, capsule to be measured be put into this container, airtight container, and by the mode such as back up pad or fixed mount, the volume of container first be remained on initial value V1.
Carry out vacuum pumping to container, make the air pressure in container drop to P1, in the process, the air of capsule can spill from the gap capsule housing, makes the air pressure of capsule also drop to P1, stops vacuum pumping.
Cancel back up pad or fixed mount etc. for keeping the means of vessel volume, container is automatically shunk under inside and outside differential pressure effect, until inside and outside air pressure balance, the air pressure namely in container equals ambient pressure P2, and the smaller volume of container is V2.
Identical with embodiment one, according to Boyle's law: P1 (V1-V0-V)=P2 (V2-V0-V), wherein, V0 is the volume of the capsule housing learnt in advance itself, V represents the volume of medicinal powder in capsule, just can calculate the volume of medicinal powder in capsule thus according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0, then according to the density of institute's powder charge powder in capsule, the weight of medicinal powder can be calculated further.
The difference of this embodiment and embodiment one is actual is the mode that container internal gas pressure changes, the mode of embodiment one is that air pressure is first raised then to be increased by the volume of container air pressure is declined, and the mode of the present embodiment is then first reduce air pressure then to make air pressure increase by the volume reduction of container.What in fact two kinds of modes were used is identical principle, i.e. Boyle's law.
The measurement of medicinal powder loading amount in the capsule that in fact method disclosed by the present invention is not limited to be applied in field of medicaments, in fact the cubing of the non-gaseous material of the similar constructions in other field is also comprised, i.e. the cubing of the inner non-gaseous material containing air.By changing the air pressure in container, make container, under inside and outside differential pressure, volume change occur, thus according to this change aeriferous volume in measurement of species, and extrapolate the volume of non-gaseous material further, even weight.
Above specific embodiment of the present invention is illustrated; but protection content of the present invention is not only limited to above embodiment, in art of the present invention, the usual knowledge of a GPRS; just within the scope of its technology main idea, diversified change can be carried out.
Claims (2)
1. a measuring method for capsule medicinal powder loading amount, is characterized in that comprising the following steps:
(a), choose the container of variable volume, inserted by capsule to be measured in this container, the volume of container is also remained on initial value V1 by applying external force by airtight container;
(b), in container, be filled with pressure gas or vacuum pumping carried out to container, until the air pressure in container reaches P1, and the air pressure of capsule to be measured also reaches P1, stops the operation that this fills pressure gas or vacuumizes;
(c), cancel as keeping container volume and to container externally applied forces, container is made to expand under the effect of inner and outer air pressure difference or shrink, until the air pressure in container balances with extraneous, the air pressure namely in container reaches ambient pressure P2, measures the volume V2 of now container;
(d), calculate the volume V of medicinal powder in capsule according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0, wherein, V0 is the volume of capsule housing.
2. method according to claim 1, is characterized in that: after step (d), according to the density of the volume V of measured medicinal powder and the medicinal powder of precognition, calculates the weight of medicinal powder.
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| CN201310079040.5A CN103206999B (en) | 2013-02-28 | 2013-02-28 | The measuring method of capsule medicinal powder loading amount |
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| CN103206999B true CN103206999B (en) | 2016-01-13 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104807518B (en) * | 2015-04-24 | 2016-11-30 | 深圳麦开网络技术有限公司 | A kind of measurement apparatus, container and the method for liquid in container volume |
| CN205015038U (en) * | 2015-08-28 | 2016-02-03 | 深圳麦开网络技术有限公司 | Measuring device and container through liquid volume in container of temperature correction |
| CN109813388B (en) * | 2019-01-01 | 2020-12-04 | 中国人民解放军63653部队 | Device and method for measuring comprehensive performance of tinplate packaging container |
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| US5535624A (en) * | 1990-06-02 | 1996-07-16 | Lehmann; Martin | Method of and apparatus for checking the volume of containers |
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| CN101672678A (en) * | 2009-10-19 | 2010-03-17 | 常州广为仪器科技有限公司 | Method and device for measuring volumes of irregular-shaped objects |
| CN102261941A (en) * | 2011-04-28 | 2011-11-30 | 重庆理工大学 | Method and device for measuring bomb chamber volume |
| CN102937470A (en) * | 2012-11-12 | 2013-02-20 | 中国航天科技集团公司第五研究院第五一〇研究所 | Device and method for measuring container volume by using pipeline space |
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2013
- 2013-02-28 CN CN201310079040.5A patent/CN103206999B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5535624A (en) * | 1990-06-02 | 1996-07-16 | Lehmann; Martin | Method of and apparatus for checking the volume of containers |
| CN2322128Y (en) * | 1998-01-26 | 1999-06-02 | 中华全国供销合作总社杭州茶叶研究所 | Instrument for measuring silkworm cocoon volume |
| CN201060148Y (en) * | 2007-06-07 | 2008-05-14 | 四川省食品发酵工业研究设计院 | Daqu volume weight measuring apparatus |
| CN101398323A (en) * | 2008-11-10 | 2009-04-01 | 徐嘉 | Method for non-immersiom measuring object volume with complicated shape |
| CN101672678A (en) * | 2009-10-19 | 2010-03-17 | 常州广为仪器科技有限公司 | Method and device for measuring volumes of irregular-shaped objects |
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