CN103206999A - Method for measuring capsule powder packing volume - Google Patents
Method for measuring capsule powder packing volume Download PDFInfo
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- CN103206999A CN103206999A CN2013100790405A CN201310079040A CN103206999A CN 103206999 A CN103206999 A CN 103206999A CN 2013100790405 A CN2013100790405 A CN 2013100790405A CN 201310079040 A CN201310079040 A CN 201310079040A CN 103206999 A CN103206999 A CN 103206999A
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- air pressure
- medicinal powder
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Abstract
The invention relates to a method for measuring the capsule powder packing volume. A capsule is put in a sealed container with the changeable volume, air pressure of the container is changed by charging compressed air or vacuumizing under the premise that the volume of the container is not changed, then the container changes the volume automatically under the effect of inside-outside air pressure difference, and the volume of the powder in the capsule is measured according to volume change. The method is simple and easy to implement and low in implementation cost.
Description
Technical field
The present invention relates to a kind of measuring method of measuring the volume of non-pneumatic material, particularly measure the method for the medicinal powder content that loads in the capsule.
Background technology
In the pharmaceuticals industry field, because influence of various factors such as the stability of capsule filling apparatus self and medicinal powder self-characteristic, make in the production run of capsule that the weight of institute's powder charge powder is that the capsule grain heavily exists fluctuation in it, and for the medicine for the treatment of disease, the amount of contained drug in the unit dose, be heavy just must being stabilized in the narrower scope of grain of every capsules, so pharmacy corporation can heavily carry out strict management and control and measurement to the grain of capsule, detects and reject the heavy undesirable defect ware of grain.
At present the method that capsule is carried out a remeasurement mainly is to utilize various mechanical balances, electronic balance or utilize the various weighing-appliances of weight sensor principle to carry out direct weighing measurement, but all there is this many drawback in these modes.The weighing process of various mechanical balances, electronic balance all needs to operate manually, and drawback is: detection speed is slow, inefficiency, complex operation; Can't realize on-line automatic weighing, can only be used for sampling observation, can't realize that capsule pursue grain weighs, this method still has a lot of the undesirable capsules of weight to be detected to the monitoring dynamics of capsule grain weight and limited.Though and the various equipment work efficiency of weight sensor principle of utilizing significantly improves, can realize capsule is weighed by grain, its remarkable drawback is also arranged: equipment precision, cost are very expensive, are unfavorable for promoting at pharmacy corporation; System complex, maintenance difficulties is big, the maintenance cost height.
Summary of the invention
The assay method that the purpose of this invention is to provide a kind of capsule medicinal powder loading amount, it can measure the content of capsule filling medicinal powder rapidly to the batch capsule, and cost is very low.
To achieve these goals, the invention provides a kind of measuring method of capsule medicinal powder loading amount, may further comprise the steps:
(a), choose the container of variable volume, capsule to be measured is inserted in this container, airtight container also remains on initial value V1 by applying external force with the volume of container;
(b), in container, charge into pressure gas or container is carried out vacuum pumping, the air pressure in container reaches P1, and the air pressure of capsule to be measured also reaches P1, stops the operation that this fills compression gas or vacuumizes;
(c), cancel to keeping container volume to the container externally applied forces, make container under the effect of inner and outer air pressure difference, expand or shrink, the air pressure in container and extraneous balance, namely the interior air pressure of container reaches ambient pressure P2, measures the volume V 2 of container at this moment;
(d), calculate the volume V of medicinal powder in the capsule according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0, wherein, V0 is the volume of capsule housing.
Cancelling the container externally applied forces, make container under the effect of inside and outside differential pressure, expand or the process of shrinking in, the air pressure in the capsule also can be along with gas spills or enters and change from the gap of capsule shells, until reaching ambient pressure P2.Variation meets Boyle's law and the unconverted principle of the volume of fixed substance according to gas volume, can measure the cumulative volume of capsule shells and medicinal powder, finally draws the volume of medicinal powder.Whole measuring process is finished fast, and is simple and easy to implement.
Further, in step (d) afterwards, according to the density of the medicinal powder of the volume V of measured medicinal powder and precognition, can calculate the weight of medicinal powder, with more realistic demands of applications.
Advantage of the present invention is: by input pressurized air or vacuumize to change the air pressure of container, and in this process by applying the constancy of volume that external force keeps container, after treating that the interior air pressure of container reaches certain value, cancel the container externally applied forces, make container under the effect of inner and outer air pressure difference, change volume automatically, calculate medicinal powder loading amount in the capsule according to final volume, should method is simple, and implementation cost is low.Compare with the weight sensor class screening installation of weighing, this method is all very low to the requirement of the collection of the measure of precision of equipment, signal and aspects such as intractability and anti-interference, the equipment cost that is used for this method of execution also can be lower, and be convenient to safeguard, is beneficial at pharmacy corporation and promotes the use of.
Embodiment
The present invention expands container or contraction by form draught head inside and outside the container of placing capsule, and measure medicinal powder content in the capsule to be measured according to the volume-variation before and after the container, and the inside and outside volume of air of capsule constitutes the volume of container jointly in the housing volume of the volume of medicinal powder and capsule to be measured and the container, the present invention utilizes gas volume to change to meet Boyle's law to get principle to calculate the inside and outside volume of air of capsule, thereby records medicinal powder volume in the capsule according to formula.Be described in detail below in conjunction with the content of the present invention of several embodiment.
Embodiment one:
Choose the changeable container of volume, it is flexible for example having the part wall on the container at least, or cylinder etc.Capsule to be measured is put into container, airtight container, and by modes such as back up pad or fixed mounts the volume of container is remained on initial value V1 earlier.
Feed pressurized air in container, the air pressure in the container is risen gradually, pressurized air can enter capsule by the gap on the capsule housing, thereby the air pressure of capsule also can rise gradually, and the air pressure in container reaches P1, stops inflation.
Remove the means that be used for to keep its container that are applied on the container, container can expand automatically, drop to ambient pressure to its air pressure inside to equate, i.e. and P2, at this moment, the volume of container can increase to V2.
According to Boyle's law as can be known: P1 (V1-V0-V)=P2 (V2-V0-V), wherein, V0 is the volume of the capsule housing learnt in advance itself, V represents the volume of medicinal powder in the capsule, can draw thus: volume V=(P2*V2-P1*V1)/(the P2-P1)-V0 of medicinal powder in the capsule, can further calculate the weight of medicinal powder according to the density of institute's powder charge powder in the capsule then.
Because method involved in the present invention is used for measuring medicinal powder loading amount in the capsule, charge into compressed-air actuated purpose in the container and be for pressure in the container being risen and making container under inside and outside differential pressure, produce volume change, rather than for the capsule explosion is split, therefore, charging into pressurized air need not a lot, need not to reach usual so-called absolute " high pressure " state of those skilled in the art in the container, charge into compressed-air actuated speed and also need not very fast.Perhaps, in container, capsule is carried out spacingly, split to prevent the capsule overexpansion, in this case, can not limit the compressed-air actuated amount that charges into, that is to say, can make to reach high pressure conditions in the container.
Embodiment two:
Similar to embodiment one, at first should choose the changeable container of volume, capsule to be measured is put into this container, airtight container, and by modes such as back up pad or fixed mounts the volume of container is remained on initial value V1 earlier.
Container is carried out vacuum pumping, make that the air pressure in the container drops to P1, in this process, the air of capsule can spill the gap from capsule housing, makes the air pressure of capsule also drop to P1, stops vacuum pumping.
Cancel the means that back up pad or fixed mount etc. are used for keeping vessel volume, make container shrink automatically under the inside and outside differential pressure effect, until inside and outside air pressure balance, namely the air pressure in the container equals ambient pressure P2, and the volume of container is reduced into V2.
Identical with embodiment one, according to Boyle's law as can be known: P1 (V1-V0-V)=P2 (V2-V0-V), wherein, V0 is the volume of the capsule housing learnt in advance itself, V represents the volume of medicinal powder in the capsule, just can calculate the volume of medicinal powder in the capsule thus according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0, can further calculate the weight of medicinal powder according to the density of institute's powder charge powder in the capsule then.
The actual mode that is that the container internal gas pressure changes of the difference of this embodiment and embodiment one, the mode of embodiment one is that air pressure rising earlier descends air pressure by the volume increase of container then, and the mode of present embodiment then is to reduce air pressure earlier to reduce to make pressure rises by the volume of container then.What in fact dual mode used is identical principle, i.e. Boyle's law.
In fact the disclosed method of the present invention is not limited to be applied in the measurement of medicinal powder loading amount in the capsule of field of medicaments, in fact also comprise the cubing of non-pneumatic material of the similar structure in other field, i.e. the inner cubing that contains the non-pneumatic material of air.By changing the air pressure in the container, make container under inside and outside differential pressure, volume change take place, thereby change the volume of contained air in measurement of species according to this, and further extrapolate the volume of non-pneumatic material, even weight.
More than specific embodiment of the present invention is illustrated; but protection content of the present invention is not only limited to above embodiment, in affiliated technical field of the present invention, and the common knowledge of a GPRS; just can in its technology main idea scope, carry out diversified change.
Claims (2)
1. the measuring method of a capsule medicinal powder loading amount is characterized in that may further comprise the steps:
(a), choose the container of variable volume, capsule to be measured is inserted in this container, airtight container also remains on initial value V1 by applying external force with the volume of container;
(b), in container, charge into pressure gas or container is carried out vacuum pumping, the air pressure in container reaches P1, and the air pressure of capsule to be measured also reaches P1, stops the operation that this fills compression gas or vacuumizes;
(c), cancel to keeping container volume to the container externally applied forces, make container under the effect of inner and outer air pressure difference, expand or shrink, the air pressure in container and extraneous balance, namely the interior air pressure of container reaches ambient pressure P2, measures the volume V 2 of container at this moment;
(d), calculate the volume V of medicinal powder in the capsule according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0, wherein, V0 is the volume of capsule housing.
2. method according to claim 1 is characterized in that: in step (d) afterwards, according to the density of the medicinal powder of the volume V of measured medicinal powder and precognition, calculate the weight of medicinal powder.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104807518A (en) * | 2015-04-24 | 2015-07-29 | 深圳麦开网络技术有限公司 | Measuring device, container and method of liquid volume in container |
WO2017035809A1 (en) * | 2015-08-28 | 2017-03-09 | 深圳麦开网络技术有限公司 | Measuring device for volume of liquid in container through temperature correction and container |
CN109813388A (en) * | 2019-01-01 | 2019-05-28 | 中国人民解放军63653部队 | A kind of method and device measuring galvanized iron package container comprehensive performance |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104807518A (en) * | 2015-04-24 | 2015-07-29 | 深圳麦开网络技术有限公司 | Measuring device, container and method of liquid volume in container |
WO2017035809A1 (en) * | 2015-08-28 | 2017-03-09 | 深圳麦开网络技术有限公司 | Measuring device for volume of liquid in container through temperature correction and container |
CN109813388A (en) * | 2019-01-01 | 2019-05-28 | 中国人民解放军63653部队 | A kind of method and device measuring galvanized iron package container comprehensive performance |
CN109813388B (en) * | 2019-01-01 | 2020-12-04 | 中国人民解放军63653部队 | Device and method for measuring comprehensive performance of tinplate packaging container |
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