CN103076422A - Ion chromatograph for multichannel detection and usage method thereof - Google Patents
Ion chromatograph for multichannel detection and usage method thereof Download PDFInfo
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- CN103076422A CN103076422A CN2013100103997A CN201310010399A CN103076422A CN 103076422 A CN103076422 A CN 103076422A CN 2013100103997 A CN2013100103997 A CN 2013100103997A CN 201310010399 A CN201310010399 A CN 201310010399A CN 103076422 A CN103076422 A CN 103076422A
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Abstract
The invention relates to an ion chromatograph for multichannel detection. The ion chromatograph comprises an ion chromatograph body and an automatic sampler. The ion chromatograph body comprises a plurality of channels, and the automatic sampler performs automatic sampling to the plurality of the channels. A usage method of the ion chromatograph for multichannel detection comprises steps that: (1) urinary oxalic acid and urinary citric acid in urine samples are detected in a first ion chromatograph channel; (2) blood phosphorus in blood samples is detected in a second ion chromatograph channel; (3) calcium and magnesium ions in the blood samples and the urine samples are detected in a third ion chromatograph channel; and (4) uric acid in the blood samples and the urine samples is detected in ultraviolet spectrum detection channels. The ion chromatograph for multichannel detection has the advantages that various relevant components of liquid samples are detected simultaneously, and contents of relevant components and elements of calculus are obtained through intelligent calculation, so that the whole detection time can be shortened.
Description
Technical field
The present invention relates to a kind of ion chromatograph, particularly relate to and a kind ofly can detect simultaneously indices data in the plurality of liquid by hyperchannel, the ion chromatograph and the using method thereof that shorten detection time.
Background technology
Chromatography of ions is a kind of of high performance liquid chromatography, claim again high-efficient ion chromatogram (HPIC) or Modern Ion Chromatography, its difference that is different from conventional ion exchange chromatography column chromatography mainly is to utilize resin to have very high degree of crosslinking and lower exchange capacity, sampling volume is very little, carry leacheate usually the pouring fluid to be carried out on-line automatic continuous electricity with ram pump and lead detection, thereby can detect ion component and concentration in the test solution.
Ion chromatograph of the prior art also exists defective, for example in the application of reality, the every data target of sufferer is all needed to detect, when namely needing to measure different kinds of ions composition in the plurality of liquid and concentration, such as the urine oxalic acid and the calcium ion in serium inorganic phosphorus, blood sample and the urine specimen in urine citric acid, the blood sample and the uric acid in magnesium ion, blood sample and the urine specimen etc. that need simultaneously to detect in the urine specimen, traditional method can only be with tested liquid successively sample introduction in ion chromatograph, what need is chronic, and efficient is not high.So for this defective in the ion chromatograph, the ion chromatograph of being badly in need of now after a kind of improve satisfies the demands.
Summary of the invention
The present invention is exactly to overcome existing problem in the prior art intermediate ion chromatograph in order to address the above problem, and the invention provides a kind ofly can chemically examine simultaneously indices data in the plurality of liquid by hyperchannel, shortens the ion chromatograph of chemical examination time to satisfy the demands.
To achieve these goals, technical scheme of the present invention is as follows:
A kind of ion chromatograph of multi-channel detection, comprise ion chromatograph and automatic sampler, it is characterized in that, described ion chromatograph comprises the first sampling pump, for detection of urinating oxalic acid in the urine specimen, the first chromatography of ions passage of urine citric acid, the second sampling pump, for detection of phosphate anion in the blood sample, the second chromatography of ions passage of phosphoric acid one hydrogen radical ion and dihydrogen phosphate ions concentration, the 3rd sampling pump, the 3rd chromatography of ions passage for detection of the calcium in urine specimen and the blood sample and magnesium ion, the 4th sampling pump and for detection of the ultraviolet spectrum sense channel of the uric acid in urine specimen and the blood sample, described automatic sampler connects respectively the first sampling pump, the second sampling pump, the 3rd sampling pump and the 4th sampling pump, described the first sampling pump connects the first chromatography of ions passage, the second sampling pump connects the second chromatography of ions passage, the 3rd sampling pump connects the 3rd chromatography of ions passage, the 4th sampling pump connects the ultraviolet spectrum sense channel, between described the first sampling pump and the first chromatography of ions passage, between the second sampling pump and the second chromatography of ions passage, between the 3rd sampling pump and the 3rd chromatography of ions passage, be respectively arranged with the first sampling valve between the 4th sampling pump and the ultraviolet spectrum sense channel, the second sampling valve, the 3rd sampling valve, the 4th sampling valve.
The ion chromatograph of above-mentioned a kind of multi-channel detection; it is characterized in that, between the first sampling valve and the first chromatography of ions passage, between the second sampling valve and the second chromatography of ions passage, between the 3rd sampling valve and the 3rd chromatography of ions passage, be provided with the protective device that carries out contaminant filter for the protection of chromatographic column, to sample between the 4th sampling valve and the ultraviolet spectrum sense channel.
The ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, described automatic sampler comprises electric mechanical arm, sample introduction needle and the sample injection disc of three direction of principal axis motion, and described sample introduction needle is connected on the mechanical arm, and described sample injection disc is arranged at the sample introduction needle below.
The ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, described sample introduction needle is the micro-sampling pin.
The ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, comprises that also described cleaning device comprises housing, is provided with the rinse bath that sample introduction needle is cleaned for the splendid attire cleaning fluid on the housing for the cleaning device that cleans sample introduction needle.
The ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, described sample injection disc comprises base and is used for the sample injection bottle of splendid attire sample to be tested, is provided with a plurality of pickup grooves for placing sample injection bottle on the described base, and described sample injection bottle is arranged in the pickup groove.
The ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, described sample injection disc is square, and described pickup groove is how much and is arranged on the square sample injection disc.
The ion chromatograph of above-mentioned a kind of multi-channel detection, it is characterized in that, described urine specimen is to have passed through the urine specimen of pre-treatment and without one of them of the urine specimen of pre-treatment, and described blood sample is to have passed through the blood sample of pre-treatment and without one of them of the blood sample of pre-treatment.
A kind of using method of ion chromatograph of multi-channel detection is characterized in that, may further comprise the steps:
(1) mechanical arm drives sample introduction needle and extract urine specimen in sample injection bottle, and urine specimen is injected in the first sampling pump, and the first sampling pump is delivered to urine specimen urine oxalic acid, the urine citric acid that detects in the first chromatography of ions passage in the urine specimen;
(2) mechanical arm drives sample introduction needle and extract blood sample in sample injection bottle, blood sample is injected in the second sampling pump, the second sampling pump is delivered to blood sample in the second chromatography of ions passage, detect one of them of concentration of phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions in the blood sample, then the content that is converted into element phosphor in the blood of molecular formula and the molecular weight by known phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions.What will indicate here is, we can adjust blood sample by the pH value of control ion chromatogram eluate is with which kind of form to exist after entering the chromatography of ions passage, thereby determine again the element of its existence form is carried out content detection, at last the content that is converted into element phosphor in the blood of molecular formula and the molecular weight by this known element.In one of them optimal way of the present invention, the ion chromatogram eluate that we use is carbonate system, its pH value is stablized and can be regulated, we can be by Non-leaching liquid pH value so that after detecting sample and entering the chromatography of ions passage, its contained phosphorus mainly exists with the form of phosphoric acid one hydrogen root, detects at chromatography of ions only to go out a peak;
(3) mechanical arm drives sample introduction needle and extract urine specimen in sample injection bottle, urine specimen is injected in the 3rd sampling pump, the 3rd sampling pump is delivered to urine specimen calcium ion and the magnesium ion that detects in the 3rd chromatography of ions passage in the urine specimen, after calcium ion in the urine specimen to be detected and magnesium ion finish, then mechanical arm drives sample introduction needle and extract blood sample in sample injection bottle, blood sample is injected in the 3rd sampling pump, and the 3rd sampling pump is delivered to blood sample calcium ion and the magnesium ion that detects in the 3rd chromatography of ions passage in the blood sample;
(4) mechanical arm drives sample introduction needle and extract urine specimen in sample injection bottle, urine specimen is injected in the 4th sampling pump, the 4th sampling pump is delivered to urine specimen the uric acid that detects in the ultraviolet spectrum sense channel in the urine specimen, after uric acid in the urine specimen to be detected finishes, then mechanical arm drives sample introduction needle and extract blood sample in sample injection bottle, blood sample is injected in the 4th sampling pump, and the 4th sampling pump is delivered to blood sample the uric acid that detects in the ultraviolet spectrum sense channel in the blood sample.
The using method of the ion chromatograph of above-mentioned a kind of multi-channel detection, it is characterized in that, in described (2) step, the second sampling pump is delivered to blood sample in the second chromatography of ions passage, detects wherein more than any one of concentration of phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions in the blood sample.
The using method of the ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, the each sample introduction 3-10 of described sample introduction needle microlitre.
The using method of the ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, behind the complete detected liquid of described sample introduction needle per injection, mechanical arm drives sample introduction needle and cleans to cleaning device.
The using method of the ion chromatograph of above-mentioned a kind of multi-channel detection is characterized in that, the order of described step (1) to (4) can be upset and carries out.
The using method of the ion chromatograph of above-mentioned a kind of multi-channel detection, it is characterized in that, described urine specimen is to have passed through the urine specimen of pre-treatment and without one of them of the urine specimen of pre-treatment, and described blood sample is to have passed through the blood sample of pre-treatment and without one of them of the blood sample of pre-treatment.
The invention has the beneficial effects as follows: because the multiple Related Component of plurality of liquid sample is detected simultaneously, and pass through Intelligent Calculation, provide the content of calculus Related Component or element, so can shorten the time of whole detection, strengthened greatly the work efficiency of ion chromatograph, simplify clinical workflow, also striven for the valuable time for the control patient of lithiasis patient simultaneously.
Description of drawings
Fig. 1 is structured flowchart of the present invention.
Embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, below in conjunction with concrete diagram, further set forth the present invention.
Referring to Fig. 1, a kind of ion chromatograph of multi-channel detection comprises ion chromatograph 100 and automatic sampler 200, by automatic sampler 200 sample introductions, then will detect sample and be transported in the ion chromatograph 100 and detect.
Between the first sampling pump 111 and the first chromatography of ions passage 112, between the second sampling pump 121 and the second chromatography of ions passage 122, between the 3rd sampling pump 131 and the 3rd chromatography of ions passage 132, be respectively arranged with opening and closing of the first sampling valve 113, the second sampling valve 123, the 3rd sampling valve 133, the 4th sampling valve 143, the first sampling valves 113, the second sampling valve 123, the 3rd sampling valve 133 and the 4th sampling valve 143 each passages of control between the 4th sampling pump 141 and the ultraviolet spectrum sense channel 142.
Between the first sampling valve 113 and the first chromatography of ions passage 112, between the second sampling valve 123 and the second chromatography of ions passage 122, between the 3rd sampling valve 133 and the 3rd chromatography of ions passage 132, be provided with the protective device 150 that carries out contaminant filter for the protection of chromatographic column, to sample between the 4th sampling valve 143 and the ultraviolet spectrum sense channel 142.In wherein a kind of optimal way of the present invention, protective device 150 is guard column.
In the present invention, urine specimen to be detected is to have passed through the urine specimen of pre-treatment and without one of them of the urine specimen of pre-treatment, and blood sample is also for the blood sample that passed through pre-treatment with without one of them of the blood sample of pre-treatment.
In traditional sample injection method; in order to protect the parts in the sense channel not to be corroded; the method of taking all is to dilute detected sample first; and then by being injected into manually in the sense channel; unusual trouble so not only; inefficiency has also increased operator's workload simultaneously.And in the present invention, sample introduction needle 220 is the micro-sampling pin, and each sample introduction content only is the 3-10 microlitre, fully can be in the situation that sample not be diluted, directly be delivered in the sense channel by sample introduction needle, do not need the operator manually to inject simultaneously, reached the effect of full-automatic sample introduction.
Because after each sample introduction needle 220 extracts a sample injection sense channel, may be at the sample introduction needle 220 residual residual liquid that last sample is arranged also, so the present invention also comprises for the cleaning device 240 that cleans sample introduction needle 220, cleaning device 240 comprises housing, be provided with the rinse bath that sample introduction needle is cleaned for the splendid attire cleaning fluid on the housing, after each sample introduction needle 220 sample drawn sample introductions, drive sample introduction needle 220 by mechanical arm 210 and to the rinse bath of cleaning device 240, once clean, wash the residual liquid on the most sample introduction needle 220.
A kind of using method of ion chromatograph of multi-channel detection is characterized in that, may further comprise the steps:
(1) mechanical arm 210 drives sample introduction needle 220 and extract urine specimen in sample injection bottle, urine specimen is injected in the first sampling pump 111, and the first sampling pump 111 is delivered to urine specimen urine oxalic acid, the urine citric acid that detects in the first chromatography of ions passage 112 in the urine specimen;
(2) mechanical arm 210 drives sample introduction needle 220 and extract blood sample in sample injection bottle, blood sample is injected in the second sampling pump 121, the second sampling pump 121 is delivered to blood sample in the second chromatography of ions passage 122, detect one of them of concentration of phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions in the blood sample, then the content that is converted into element phosphor in the blood of molecular formula and the molecular weight by known phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions.What will indicate here is, we can adjust blood sample by the pH value of control ion chromatogram eluate is with which kind of form to exist after entering the chromatography of ions passage, thereby determine again the element of its existence form is carried out content detection, at last the content that is converted into element phosphor in the blood of molecular formula and the molecular weight by this known element.In one of them optimal way of the present invention, the ion chromatogram eluate that we use is carbonate system, its pH value is stablized and can be regulated, we can be by Non-leaching liquid pH value so that after detecting sample and entering the chromatography of ions passage, its contained phosphorus mainly exists with the form of phosphoric acid one hydrogen root, detects at chromatography of ions only to go out a peak;
(3) mechanical arm 210 drives sample introduction needle 220 and extract urine specimen in sample injection bottle, urine specimen is injected in the 3rd sampling pump 131, the 3rd sampling pump 131 is delivered to urine specimen calcium ion and the magnesium ion that detects in the 3rd chromatography of ions passage 132 in the urine specimen, after calcium ion in the urine specimen to be detected and magnesium ion finish, then mechanical arm 210 drives sample introduction needle 220 and extract blood sample in sample injection bottle, blood sample is injected in the 3rd sampling pump 131, and the 3rd sampling pump 131 is delivered to blood sample calcium ion and the magnesium ion that detects in the 3rd chromatography of ions passage 132 in the blood sample;
(4) mechanical arm 210 drives sample introduction needle 220 and extract urine specimen in sample injection bottle, urine specimen is injected in the 4th sampling pump 141, the 4th sampling pump 141 is delivered to urine specimen the uric acid that detects in the ultraviolet spectrum sense channel 142 in the urine specimen, after uric acid in the urine specimen to be detected finishes, then mechanical arm 210 drives sample introduction needle 220 and extract blood sample in sample injection bottle, blood sample is injected in the 4th sampling pump 141, and the 4th sampling pump 141 is delivered to blood sample the uric acid that detects in the ultraviolet spectrum sense channel 142 in the blood sample.
In the present invention, urine specimen to be detected is to have passed through the urine specimen of pre-treatment and without one of them of the urine specimen of pre-treatment, and blood sample is also for the blood sample that passed through pre-treatment with without one of them of the blood sample of pre-treatment.
In (2) step, the second sampling pump 121 is delivered to blood sample in the second chromatography of ions passage 122, detects wherein more than any one of concentration of phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions in the blood sample.
In order to protect the parts in the sense channel not to be corroded, sample introduction needle 220 each sample introduction 3-10 microlitres.Behind the complete detected liquid of simultaneously sample introduction needle 220 per injections, mechanical arm 210 drives sample introduction needle 220 and cleans to cleaning device 240.
In the present invention, the order of step (1) to (4) can be upset and carries out.
The invention has the beneficial effects as follows: because the multiple Related Component of plurality of liquid sample is detected simultaneously, and pass through Intelligent Calculation, provide the content of calculus Related Component or element, so can shorten the time of whole detection, strengthened greatly the work efficiency of ion chromatograph, simplify clinical workflow, also striven for the valuable time for the control patient of lithiasis patient simultaneously.
Above demonstration and described ultimate principle of the present invention, principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; that describes in above-described embodiment and the instructions just illustrates principle of the present invention; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (10)
1. the ion chromatograph of a multi-channel detection, comprise ion chromatograph and automatic sampler, it is characterized in that, described ion chromatograph comprises the first sampling pump, for detection of urinating oxalic acid in the urine specimen, the first chromatography of ions passage of urine citric acid, the second sampling pump, for detection of phosphate anion in the blood sample, the second chromatography of ions passage of phosphoric acid one hydrogen radical ion and dihydrogen phosphate ions concentration, the 3rd sampling pump, the 3rd chromatography of ions passage for detection of the calcium in urine specimen and the blood sample and magnesium ion, the 4th sampling pump and for detection of the ultraviolet spectrum sense channel of the uric acid in urine specimen and the blood sample, described automatic sampler connects respectively the first sampling pump, the second sampling pump, the 3rd sampling pump and the 4th sampling pump, described the first sampling pump connects the first chromatography of ions passage, the second sampling pump connects the second chromatography of ions passage, the 3rd sampling pump connects the 3rd chromatography of ions passage, the 4th sampling pump connects the ultraviolet spectrum sense channel, between described the first sampling pump and the first chromatography of ions passage, between the second sampling pump and the second chromatography of ions passage, between the 3rd sampling pump and the 3rd chromatography of ions passage, be respectively arranged with the first sampling valve between the 4th sampling pump and the ultraviolet spectrum sense channel, the second sampling valve, the 3rd sampling valve, the 4th sampling valve.
2. the ion chromatograph of described a kind of multi-channel detection according to claim 1; it is characterized in that, between the first sampling valve and the first chromatography of ions passage, between the second sampling valve and the second chromatography of ions passage, between the 3rd sampling valve and the 3rd chromatography of ions passage, be provided with the protective device that carries out contaminant filter for the protection of chromatographic column, to sample between the 4th sampling valve and the ultraviolet spectrum sense channel.
3. the ion chromatograph of described a kind of multi-channel detection according to claim 2, it is characterized in that, described automatic sampler comprises electric mechanical arm, sample introduction needle and the sample injection disc of three direction of principal axis motion, described sample introduction needle is connected on the mechanical arm, described sample injection disc is arranged at the sample introduction needle below, and described sample introduction needle is the micro-sampling pin, also comprises for the cleaning device that cleans sample introduction needle, described cleaning device comprises housing, is provided with the rinse bath that sample introduction needle is cleaned for the splendid attire cleaning fluid on the housing.
4. the ion chromatograph of described a kind of multi-channel detection according to claim 3, it is characterized in that, described sample injection disc comprises base and is used for the sample injection bottle of splendid attire sample to be tested, be provided with a plurality of pickup grooves for placing sample injection bottle on the described base, described sample injection bottle is arranged in the pickup groove, described sample injection disc is square, and described pickup groove is how much and is arranged on the square sample injection disc.
5. the ion chromatograph of described a kind of multi-channel detection according to claim 1, it is characterized in that, described urine specimen is to have passed through the urine specimen of pre-treatment and without one of them of the urine specimen of pre-treatment, and described blood sample is to have passed through the blood sample of pre-treatment and without one of them of the blood sample of pre-treatment.
6. the using method of the ion chromatograph of a multi-channel detection is characterized in that, may further comprise the steps:
(1) mechanical arm drives sample introduction needle and extract urine specimen in sample injection bottle, and urine specimen is injected in the first sampling pump, and the first sampling pump is delivered to urine specimen urine oxalic acid, the urine citric acid that detects in the first chromatography of ions passage in the urine specimen;
(2) mechanical arm drives sample introduction needle and extract blood sample in sample injection bottle, blood sample is injected in the second sampling pump, the second sampling pump is delivered to blood sample in the second chromatography of ions passage, detect one of them of concentration of phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions in the blood sample, then the content that is converted into element phosphor in the blood of molecular formula and the molecular weight by known phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions;
(3) mechanical arm drives sample introduction needle and extract urine specimen in sample injection bottle, urine specimen is injected in the 3rd sampling pump, the 3rd sampling pump is delivered to urine specimen calcium ion and the magnesium ion that detects in the 3rd chromatography of ions passage in the urine specimen, after calcium ion in the urine specimen to be detected and magnesium ion finish, then mechanical arm drives sample introduction needle and extract blood sample in sample injection bottle, blood sample is injected in the 3rd sampling pump, and the 3rd sampling pump is delivered to blood sample calcium ion and the magnesium ion that detects in the 3rd chromatography of ions passage in the blood sample;
(4) mechanical arm drives sample introduction needle and extract urine specimen in sample injection bottle, urine specimen is injected in the 4th sampling pump, the 4th sampling pump is delivered to urine specimen the uric acid that detects in the ultraviolet spectrum sense channel in the urine specimen, after uric acid in the urine specimen to be detected finishes, then mechanical arm drives sample introduction needle and extract blood sample in sample injection bottle, blood sample is injected in the 4th sampling pump, and the 4th sampling pump is delivered to blood sample the uric acid that detects in the ultraviolet spectrum sense channel in the blood sample.
7. the using method of the ion chromatograph of described a kind of multi-channel detection according to claim 6, it is characterized in that, in described (2) step, the second sampling pump is delivered to blood sample in the second chromatography of ions passage, detects wherein more than any one of concentration of phosphoric acid one hydrogen radical ion, phosphate anion and dihydrogen phosphate ions in the blood sample.
8. the using method of the ion chromatograph of described a kind of multi-channel detection according to claim 7, it is characterized in that, the each sample introduction 3-10 of described sample introduction needle microlitre, behind the complete detected liquid of described sample introduction needle per injection, mechanical arm drives sample introduction needle and cleans to cleaning device.
9. the using method of the ion chromatograph of described a kind of multi-channel detection according to claim 6 is characterized in that, the order of described step (1) to (4) can be upset and carries out.
10. the using method of the ion chromatograph of described a kind of multi-channel detection according to claim 6, it is characterized in that, described urine specimen is to have passed through the urine specimen of pre-treatment and without one of them of the urine specimen of pre-treatment, and described blood sample is to have passed through the blood sample of pre-treatment and without one of them of the blood sample of pre-treatment.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104330492A (en) * | 2014-10-31 | 2015-02-04 | 华南理工大学 | Intelligent automatic switching multi-channel ion chromatographic column connecting device |
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Effective date of registration: 20161201 Address after: 430079 A7 Exhibition Center, No. 858, high tech Avenue, East Lake Development Zone, Hubei, Wuhan, China Patentee after: Five channel medical technology (Wuhan) Co., Ltd. Address before: 310013 Hangzhou, Zhejiang Province, Xihu District, Zhejiang Road, No. 38, No. Patentee before: Liu Guanlin |