CN103007432A - Integrated device for modulating and detecting brain functions - Google Patents
Integrated device for modulating and detecting brain functions Download PDFInfo
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- CN103007432A CN103007432A CN2012105603699A CN201210560369A CN103007432A CN 103007432 A CN103007432 A CN 103007432A CN 2012105603699 A CN2012105603699 A CN 2012105603699A CN 201210560369 A CN201210560369 A CN 201210560369A CN 103007432 A CN103007432 A CN 103007432A
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Abstract
The invention discloses an integrated device for modulating and detecting brain functions. A silicon rubber case is sleeved on the surface of a transcranial magnetic stimulation coil, an inner ring and an outer ring of the silicon rubber case are provided with a plurality of holes at different distances, near infrared transmitting and receiving probes can be conveniently inserted into the holes, the probes can be firmly held by the aid of elasticity of silicon rubber, the upper positions and the lower positions of the probes can be optionally adjusted, and close contact of the probes and the scalp of a detected portion is ensured. A miniature near infrared brain function detection device sets frequencies through a microprocessor, the frequencies are transmitted and received by a near infrared ray with a 690nm wavelength and a near infrared ray with a 830nm wavelength respectively, a plurality of LD (laser diode)/LED emitting light sources distributed at the center of the stimulation coil are sequentially lightened in a time-sharing multiplexing mode, signals detected by the surrounding probes are processed, changes of deoxyhemoglobin and blood flow are displayed on a liquid crystal display screen, and changes of the strength, the range and the depth of brain function activities corresponding to each detection channel through transcranial magnetic stimulation are reflected.
Description
Technical field
The present invention relates to a kind of brain function modulation and the integrated apparatus that detects.Refer more particularly to method and integrated apparatus that a kind of non-invasive transcranial magnetic stimulation and miniature nearly Near-infrared Brain Function detection technology are implemented simultaneously.
Background technology
Transcranial magnetic stimulation instrument (Transcranial Magnetic Stimulation, TMS) is that the non-invasive cerebral cortex that occurred later in 1985 stimulates and the new technique of modulation, is being used widely aspect brain science research and clinical diagnosis, the treatment.TMS produces faradize cerebral cortex nerve and produces a series of physiological actions and biochemical reaction at intracranial with the without hindrance painless skull that passes in the magnetic field of pulse ringing.TMS has influence on the at all levels of molecule, synapse, cell, network, functional areas, system structure and decision behavior in neuroscience; In recent years, day by day be subject to people's attention in fields such as rehabilitation medicine, psychologic medicine, neurosciences, promoted gradually aspect clinical and the scientific research.
The principle of TMS modulation function of nervous system is to act on local nerve and network with different stimulated pattern and stimulus parameter, the synapse bonding strength of double regulation control nerve, the long time journey of namely modulating function of nervous system strengthens or the inhibition of long time journey, the two-ways regulation nerve excitability, regulate regional cerebral blood flow and metabolism, and regulate and control function of nervous system, treatment delayed ischemic neurological deficits disease with this.
The dual regulation of TMS has the stimulation frequency dependence, can improve the nerve excitability of stimulation location with the high frequency repetitive stimulation, improves oxygen consumption and metabolism.The repetitive stimulation effect of low frequency is opposite, can suppress nerve excitability, reduce blood flow.But the factor that affects the TMS effect of stimulation is a lot, all can affect the effect of stimulation of TMS such as size and shape, stimulation distance and angle, stimulus intensity and the pattern of stimulating coil; The stimulation of TMS also is subjected to neural activity state, neural activity history, neural autostability, individual variation, pathological change and pharmaceutically-active the impact.Therefore TMS need to consider these factors, select the stimulus parameter of individuation, in time observe effect of stimulation, in time adjust stimulus parameter.
TMS is usually used in stimulating the motor area of cerebral cortex, can make the target flesh of nervus motorius control shrink shake, the amplitude of the Motion Evoked Potential (MEP) on the target flesh commonly used detects effect of stimulation, decide stimulus parameter, according to predeterminated target, artificial intervention function of nervous system comes the irritability of modulation movement nerve.Find again to stimulate now all the other positions of brain, (such as the frontal lobe back of the body outside, temporal lobe, top) can treat some neural mental function disorder diseases, such as depression, schizophrenia etc.But stimulate these positions not have target organ can detect effect of stimulation, the effect of conventional high frequency stimulation is subject to multifactorial impact, these uncertain factors need correct selection stimulus modelity and parameter, if can not detect in real time effect of stimulation, variation that can not determine the oxygen consumption of stimulation location just is difficult to determine that TMS is on the impact of stimulation location, be difficult to determine the therapeutic effect of TMS, hindered application, development and the popularization of TMS.
Because the excitement of brain and activity increase metabolism, oxygen consumption increases; Present useful work can property magnetic resonance (fMRI) and positron emission tomography scanning imaging system (PET) detect the non-motor region of TMS stimulation brain the post-stimulatory therapeutic effect of TMS judged in the change of cerebral blood flow and biochemical metabolism, but these two kinds of equipment are all very expensive, detection time, environment long, that head can not move, seal produced fear of being enclosed easily, these unfavorable factors have also affected results of stimulation, limited the research range of neuroscience, be difficult in clinical practice with universal.
The neural activity of brain needs oxygen consumption, and oxygen is provided by the hemoglobin in the blood.The nearly near-infrared Optical Imaging of Functional Brain: An Introductory of Novel noninvasive (the Functional near infrared spectroscopy fNIRS) technology that occurs the nineties in 20th century can provide the information of intracranial oxygenated blood red eggs and deoxyhemoglobin concentration change, and the increase of neural activity and HbO2 Oxyhemoglobin, the increase of blood flow are relevant.The regional oxygen uptake amount that fNIRS reflection brain function activity causes and the variation of blood flow, its accuracy and credibility are confirmed by fMRI and PET.Near infrared ray can penetrate skull, and the part near-infrared can return by the scattering of cerebral tissue, passes skull (penetrate darker, the distance of returning skull is far away) in the 3-5 centimeters.HbO2 Oxyhemoglobin and deoxyhemoglobin change to different, brain function activity place Oxygenated blood Lactoferrin and the deoxyhemoglobin ratio of near-infrared absorption spectrum frequency, make and inject the near infrared scattered light intensity that skull arrives corticocerebral different wave length and change, can be in real time to detect this variation with high-sensitive probe-photoelectric sensor, as fMRI, indirectly understand the functional activity of brain by the variation that detects the local blood oxygen of brain and blood flow.
The operation principle of fNIRS is simple and reliable, launch the near infrared light that wavelength is 830nm and 690nm by laser diode (LD) or light emitting diode (LED), can detect HbO2 Oxyhemoglobin and deoxyhemoglobin respectively, available photoelectric receiving diode with same frequency characteristic or light cell are as probe, detect the near infrared scattering of different frequency, then signal is amplified, filtering, can show in real time that each is positioned at the variation of light intensity on brain surface's different parts sense channel, thereby reflect the variation of different brains position HbO2 Oxyhemoglobin and blood flow, through software processes, signal amplitude is converted to different colors, be presented on the head phantom model variation of the large brain regional blood flow of Real time dynamic display and function.
The fNIRS advantage of system be safe, easy, cost is low, can detect in real time the brain part functional activity and without fixing head, repeated experiments repeatedly.Overcome the deficiency of fMRI and PET, and be fit to and TMS carries out functional measurement of human brain without interfering with each other simultaneously.But TMS and these two kinds of new techniques of fNIRS only have independently equipment at present.The emission of functional near-infrared imaging equipment is all passed through optical fibers with reception, although optical fibers is not subjected to electromagnetic interference, but the stimulating coil of TMS is difficult to move operation at the fibre-optic head that gathered, too much optical fibers is fixed on the headstock time-consuming bothersome, the stimulating coil of TMS can't effectively be located and stimulates accurately position, cortex target area near skull in the middle of the optical fibers, works simultaneously so that present TMS and fNIRS are very difficult.
Summary of the invention
Main purpose of the present invention provides a kind of brain function modulation and the integrated apparatus that detects, be suitable for when implementing brain function and stimulate, detect simultaneously stimulation location deoxyhemoglobin and blood flow and change and then reflect the integrated apparatus that stimulation location neural activity, nerve excitability change.Needing to understand stimulation location during magnetic stimulates is to increase or suppress to the result-nerve excitability of neural two-ways regulation, and corresponding is that HbO2 Oxyhemoglobin increases or reduces, and also needs to understand scope and the degree of depth of stimulation.The present invention can realize easily that the limit stimulates frontier inspection to look into, and the monitoring transcranial magnetic stimulation is to direction, degree, coverage and the degree of depth of brain function modulation, in order to select better stimulus modelity, stimulus parameter to reach desirable effect of stimulation.
Technical scheme of the present invention: a kind of brain function modulation of the present invention comprises transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument with the integrated apparatus that detects, the microprocessor of described Near-infrared Brain function optical imaging instrument is connected with the external trigger of transcranial magnetic stimulation instrument by time-delay trigger, around the stimulating coil that the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are nested in transcranial magnetic stimulation instrument.
Described Near-infrared Brain function optical imaging instrument is miniature Near-infrared Brain function optical imaging instrument, comprise microprocessor, the amplifier that is connected with microprocessor, wave filter, analogue selector, analog-digital converter, digital to analog converter, bidirectional constant driver, time-delay trigger, liquid crystal touch screen, the bidirectional constant driver is connected with transmitting probe, and receiving transducer is connected with amplifier; Near-infrared Brain function optical imaging instrument and liquid crystal touch screen thereof are installed on the handle of transcranial magnetic stimulation instrument.
The transmitting probe of described Near-infrared Brain function optical imaging instrument and receiving transducer are nested on the stimulating coil of transcranial magnetic stimulation instrument by having plasticity and elastic silica gel sheath, silica gel sheath comprises bottom surface, the jacket and inner sleeve vertical with the bottom surface, overcoat is enclosed within the outside of the stimulating coil of transcranial magnetic stimulation instrument, in be embedded in the inboard of the stimulating coil of transcranial magnetic stimulation instrument, having probe that hole is installed on the jacket and inner sleeve; The stimulating coil coupling of the height of jacket and inner sleeve and the shape of inside and outside wall, size and transcranial magnetic stimulation instrument.
The external trigger of described Near-infrared Brain function optical imaging instrument to the triggering signal of transcranial magnetic stimulation instrument is: the input and output of probe locked in the out-of-work 1ms of Near-infrared Brain function optical imaging instrument, the stimulating coil that time-delay 0.5ms triggers transcranial magnetic stimulation instrument produces the 0.3ms pulsed magnetic field, after pulsed magnetic field output stops, unlocking through Near-infrared Brain function optical imaging instrument behind the 0.2ms.
Bidirectional constant drive circuit in the described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and the constant-current circuit that is attached thereto, the outfan of bidirectional bridge type drive circuit directly drives the transmitting probe of two-way antiparallel two LEDs or laser diode LD composition, the wavelength of a luminous tube is 830nm, the wavelength of another luminous tube is 690nm, is taken turns the near infrared light emission of two luminous tubes of current control different wave length by the microprocessor timesharing; The input of constant-current circuit is connected to set output terminal with microprocessor, is regulated the size of constant current by microprocessor.
Described transmitting probe and receiving transducer are elongated cylindrical, can conveniently insert the installation hole on the silica gel sheath, and by the clamping of elastic silica gel hole, the degree of depth of scalable in hole is installed reaches the close contact with scalp.
The installation site is selected according to the needs that detect the position in the transmitting probe of described Near-infrared Brain function optical imaging instrument and the installation position of receiving transducer, and keeping distance between the two is 3～5cm.
Preferably, the transmitting probe of described Near-infrared Brain function optical imaging instrument and receiving transducer are placed on respectively the probe of the jacket and inner sleeve of silica gel sheath and install in the hole, and the distance between transmitting probe and receiving transducer is 3-5cm.More preferably receiving transducer is placed on the inner sleeve of silica gel sheath, in the stimulating coil centre.
The transmitting probe of described Near-infrared Brain function optical imaging instrument is established 1～10,1～10 of receiving transducer; Probe diameter all is 2.5mm.
Advantage of the present invention: set the near infrared emission of two kinds of wavelength and the operating frequency of reception by microprocessor in the miniature Near-infrared Brain function optical imaging instrument of the present invention, adopt continuous wave time-sharing multiplex pattern to light in turn successively several transmitting probes that are distributed in the stimulating coil inboard, with 690nm, the magnetic stimulation location that the near infrared light of 830nm wavelength is to be measured, then several detectors by the stimulating coil outside receive through the optical signal after the tissue decay, amplify through opto-electronic conversion and signal, Filtering Processing is also carried out mould/number conversion, when utilizing the timesharing of software control circuit to take turns to operate, the multi-channel data that gathers is carried out real-time operation, and in the variation that small-sized liquid crystal screen display goes out HbO2 Oxyhemoglobin and blood flow, reflect each access sites the power of corresponding brain zone function activity, the variation that movable scope and the degree of depth occur.
The present invention simply saves time when clinical manipulation, utilize first support relative fixing with irriate person's head stimulating coil 1a, then just allow near infrared transmitting probe and receiving transducer two kinds of equipment be independent of each other by the hole on the magnetic stimulating coil silica gel sheath and scalp close contact, work simultaneously.
Expense of the present invention is low, only need customize the cheaply silica gel sheath of TMS stimulating coil, both can be used for existing TMS equipment, can be used for again redesign and the making of novel TMS equipment.Silica gel sheath both had been convenient to cleaning and sterilizing cheaply, can be used as again the consumptive material that patient uses separately.
The invention process is simple, and is easy to operate, is convenient to adjust stimulus parameter and stimulus modelity according to real-time fNIRS testing result in stimulation, to reach the expection purpose of intervening function of nervous system.The present invention has improved the stimulation curative effect of TMS, has enlarged the range of application of fNIRS, for scientific research, detection, the treatment of neuroscience provides a kind of new method and utility.
In sum, the present invention combines the new technique in two kinds of neurosciences, detects the effect of stimulation that TMS stimulates any position of brain with fNIRS in real time.Solved the difficult problem that TMS stimulates non-motor region not have target organ to detect.Exempted the great number medical expense of fMRI, PET detection TMS effect of stimulation.
Description of drawings
Fig. 1 is circuit theory logic diagram of the present invention.
Fig. 2 is the bidirectional constant driving principle block diagram of miniature Near-infrared Brain function optical imaging instrument.
Fig. 3 is the transmitting probe of Near-infrared Brain function optical imaging instrument and the inside and outside sketch map of stimulating coil that receiving transducer is nested in transcranial magnetic stimulation instrument.
Fig. 4 is the A-A cutaway view of Fig. 3.
Fig. 5 is the sketch map of silica gel sheath.
Fig. 6 sketch map that to be the present invention use when detecting people's brain function modulation.
Fig. 7 is transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument time-sharing work oscillogram.
Fig. 8 is the graph of a relation of distance and investigation depth between transmitting probe and the receiving transducer.
Fig. 9 is the sketch map that the present invention is used for figure-eight coil.
The specific embodiment
Be described in further detail embodiments of the invention below in conjunction with accompanying drawing.
Fig. 1 is circuit theory logic diagram of the present invention:
The invention provides a kind of brain function modulation and the integrated apparatus that detects, comprise transcranial magnetic stimulation instrument 1 and Near-infrared Brain function optical imaging instrument 2, the microprocessor of described Near-infrared Brain function optical imaging instrument 2 is connected with the external trigger of transcranial magnetic stimulation instrument by time-delay trigger, and the transmitting probe 2a of Near-infrared Brain function optical imaging instrument 2 and receiving transducer 2b are nested in around the stimulating coil 1a of transcranial magnetic stimulation instrument.
Near-infrared Brain function optical imaging instrument of the present invention is miniature Near-infrared Brain function optical imaging instrument, comprise microprocessor, the amplifier that is connected with microprocessor, wave filter, analogue selector, analog-digital converter, digital to analog converter, bidirectional constant driver, time-delay trigger, liquid crystal touch screen, the bidirectional constant driver is connected with transmitting probe 2a, and receiving transducer 2b is connected with amplifier.
Fig. 2 is the bidirectional constant driving principle block diagram of miniature Near-infrared Brain function optical imaging instrument:
Bidirectional constant drive circuit in the described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and the constant-current circuit that is attached thereto, the outfan of bidirectional bridge type drive circuit directly drives the transmitting probe that two-way antiparallel two light emitting diodes form, the wavelength of a luminous tube is 830nm, the wavelength 690nm of a luminous tube is taken turns the near infrared light emission of two luminous tubes of current control different wave length by the microprocessor timesharing; The input of constant-current circuit is connected to set output terminal with microprocessor.
The bridge circuit of bidirectional constant driver is comprised of audion Q1～Q4, the outfan of bridge circuit directly drives two-way antiparallel two light emitting diodes (LED) or laser diode (LD), when bridge circuit audion Q1～Q4 brachium pontis conducting, flow through the luminous tube of D830nm, when brachium pontis audion Q2, Q3 conducting, the luminous tube conducting of D690nm, the control of the near-infrared light source of conducting is finished by interlaced pulse control Q6 and the Q7 that microprocessor sends in turn.Constant-current circuit is comprised of audion Q5, resistance R 9, R10 and amplifier A, received the anode of amplifier in through the given output intensity of D/A conversion by microprocessor, negative terminal is received on the current detecting feedback resistance R9, when electric current less than set-point, audion Q5 conducting, electric current is during greater than set-point, voltage drop on the R9 increases, the negative terminal voltage of amplifier A increases, output reduces to make Q5 to turn-off, output current reaches electric current according to the set-point constant output with the conducting state of negative feedback type control Q5.
Described pick-up probe is the photosensitive diode of near-infrared, audion, photoconductive resistance or the light-sensitive cell of available respective wavelength also, the near infrared signal that also can adopt the optical fibers conduction to detect.
Fig. 7 is transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument time-sharing work oscillogram:
The external trigger of Near-infrared Brain function optical imaging instrument to the triggering signal of transcranial magnetic stimulation instrument is: the input and output of probe locked in the out-of-work 1ms of Near-infrared Brain function optical imaging instrument, the stimulating coil that time-delay 0.5ms triggers transcranial magnetic stimulation instrument produces the 0.3ms pulsed magnetic field, after pulsed magnetic field output stops, unlocking through Near-infrared Brain function optical imaging instrument behind the 0.2ms.Avoid magnetic to stimulate with near-infrared and work simultaneously, hide the strong pulsed magnetic field of transcranial magnetic stimulation device output to the interference of near infrared device.The operating frequency of transcranial magnetic stimulation device is generally 1～100HZ, and namely each treatment cycle is 10～1000ms.
Fig. 5 is the sketch map of silica gel sheath:
The transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are nested on the stimulating coil of transcranial magnetic stimulation instrument by having plasticity and elastic silica gel sheath, silica gel sheath comprises bottom surface 2g, overcoat 2c and the inner sleeve 2d vertical with the bottom surface, overcoat 2c is enclosed within the outside of the stimulating coil of transcranial magnetic stimulation instrument, inner sleeve 2d is embedded in the inboard of the stimulating coil of transcranial magnetic stimulation instrument, has probe that hole is installed on overcoat 2c and the inner sleeve 2d; The stimulating coil coupling of the height of overcoat 2c and inner sleeve 2d and the shape of inside and outside wall, size and transcranial magnetic stimulation instrument.
Silica gel sheath is the physical dimension according to the magnetic stimulation coil, makes the silica gel outer of a stimulating coil, and outer edge is turned back so that stimulating coil firmly embeds within the silica gel outer.Be provided with the different installation hole of several distances inside and outside the silica gel outer, be convenient near infrared emission and receiving transducer and insert hole, utilize the elasticity of silica gel, make less hole can the secure grip cylindrical elongate probe and can arbitrarily regulate the up and down orientation of probe, guarantee probe and the scalp close contact that detects the position.
Fig. 3, Fig. 4 are the transmitting probe of Near-infrared Brain function optical imaging instrument and the inside and outside sketch map of stimulating coil that receiving transducer is nested in transcranial magnetic stimulation instrument: transmitting probe and receiving transducer are elongated cylindrical, can conveniently insert the installation hole on the silica gel sheath, by the clamping of elastic silica gel hole, the scalable depth reaches the close contact with scalp.
The transmitting probe of Near-infrared Brain function optical imaging instrument is established 1～10, preferred 1; 1～10 of receiving transducer, preferred 2; The installation position is according to the installation hole of the needs selection silica gel sheath that detects the position, and keeping distance between the two is 3～5cm.Preferred emission probe and receiving transducer are placed on respectively the overcoat 2c of silica gel sheath and the probe of inner sleeve 2d is installed in the hole.
The transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are placed on respectively the overcoat 2c of silica gel sheath and the probe of inner sleeve 2d is installed in the hole, and the transmitting probe of Near-infrared Brain function optical imaging instrument is established 1～10,1～10 of receiving transducer.The transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are placed on respectively the overcoat 2c of silica gel sheath and the probe of inner sleeve 2d is installed in the hole, and the distance between transmitting probe and receiving transducer is 3-5cm.Miniature Near-infrared Brain function optical imaging instrument 2 and liquid crystal touch screen 2e thereof are installed on the handle 1b of transcranial magnetic stimulation instrument.
Miniature Near-infrared Brain function optical imaging instrument of the present invention comprises that one 2.5 cun color touch liquid crystal display screen is as man-machine dialogue interface, with curve or different color show different parts testing result, select near infrared emission and detect the quantity of leading and combination, select to regulate the drive current of light source probe with touch screen, select and the parameters such as amplification that adjusting is respectively led, sweep duration, filtering.
Fig. 6 sketch map that to be the present invention use when detecting people's brain function modulation:
The emission of miniature Near-infrared Brain function optical imaging instrument is connected near infrared emission probe 2a and receiving transducer 2b with twisted-pair feeder by sleeve pipe 2f with receiving transducer.Transmitting probe 2a forms the combination of some time-sharing multiplexs with in receiving transducer 2b inserts respectively installation holes different on the silica gel sheath, to detect different parts, different range, the HbO2 Oxyhemoglobin of different depth and the variation of blood flow.
Particularly, miniature Near-infrared Brain function optical imaging instrument is fixed on the handle 1b of stimulating coil 1a of transcranial magnetic stimulation instrument.The silica gel sheath static probe, the integrated carrier that uses simultaneously as two kinds of equipment.Silica gel sheath is different size and shapes according to different coil design, the edge opisthotonos can hold stimulating coil 1a, keep combining closely with stimulating coil 1a, utilize elasticity and the plasticity of silica gel material, can insert and closely grip transmitting probe 2a and receiving transducer 2b, purpose is for transmitting probe 2a and receiving transducer 2b being fixed on inside and outside the stimulating coil 1a, and energy close contact scalp, probe can be moved along with the movement of stimulating coil 1a, and the function of nervous system of arbitrarily detecting any stimulation location changes.
Fig. 8 is the graph of a relation of distance and investigation depth between transmitting probe and the receiving transducer:
Transmitting probe is relevant with the degree of depth of surveying the position with the distance between the receiving transducer, when between the two distance L 1=3cm, investigation depth H1=3cm, if the distance of detecting head and light source is increased to L2=5cm, investigation depth H2=5cm then, the distance of therefore regulating between receiving transducer and the transmitting probe can increase detection range and the degree of depth, can detect the situation of intracranial blood oxygen and blood flow on a large scale simultaneously with a plurality of transmitting probes, and then more reflect scope and the intensity of brain neurological motion.
Fig. 9 is the sketch map that the present invention is used for figure-eight coil: described stimulating coil silica gel outer can be made different size and shapes, to adapt to various stimulating coils, such as the most frequently used circle or figure-eight coil.
The above only is the preferred embodiments of the present invention; be not so restriction protection scope of the present invention; every equivalent structure or flow process conversion that utilizes content of the present invention to do, or directly or indirectly be used in other relevant technical field, all in protection scope of the present invention.
Claims (10)
1. a brain function is modulated and the integrated apparatus that detects, comprise transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument, it is characterized in that: the microprocessor of described Near-infrared Brain function optical imaging instrument is connected with the external trigger of transcranial magnetic stimulation instrument by time-delay trigger, around the stimulating coil that the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are nested in transcranial magnetic stimulation instrument.
2. brain function modulation according to claim 1 and the integrated apparatus that detects, it is characterized in that: described Near-infrared Brain function optical imaging instrument is miniature Near-infrared Brain function optical imaging instrument, comprise microprocessor, the amplifier that is connected with microprocessor, wave filter, analogue selector, analog-digital converter, digital to analog converter, bidirectional constant driver, time-delay trigger, liquid crystal touch screen, the bidirectional constant driver is connected with transmitting probe, and receiving transducer is connected with amplifier; Near-infrared Brain function optical imaging instrument and liquid crystal touch screen thereof are installed on the handle of transcranial magnetic stimulation instrument.
3. brain function modulation according to claim 1 and 2 and the integrated apparatus that detects, it is characterized in that: the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are nested on the stimulating coil of transcranial magnetic stimulation instrument by having plasticity and elastic silica gel sheath, silica gel sheath comprises bottom surface (2g), the overcoat vertical with the bottom surface (2c) and inner sleeve (2d), overcoat (2c) is enclosed within the outside of the stimulating coil of transcranial magnetic stimulation instrument, inner sleeve (2d) is embedded in the inboard of the stimulating coil of transcranial magnetic stimulation instrument, has probe that hole is installed on overcoat (2c) and the inner sleeve (2d); The stimulating coil coupling of the height of overcoat (2c) and inner sleeve (2d) and shape, size and the transcranial magnetic stimulation instrument of inside and outside wall.
4. brain function modulation according to claim 1 and 2 and the integrated apparatus that detects, it is characterized in that: the external trigger of Near-infrared Brain function optical imaging instrument to the triggering signal of transcranial magnetic stimulation instrument is: the input and output of probe locked in the out-of-work 1ms of Near-infrared Brain function optical imaging instrument, the stimulating coil that time-delay 0.5ms triggers transcranial magnetic stimulation instrument produces the 0.3ms pulsed magnetic field, after pulsed magnetic field output stops, unlocking through Near-infrared Brain function optical imaging instrument behind the 0.2ms.
5. brain function modulation according to claim 2 and the integrated apparatus that detects, it is characterized in that: the bidirectional constant drive circuit in the described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and the constant-current circuit that is attached thereto, the outfan of bidirectional bridge type drive circuit directly drives the transmitting probe of two-way antiparallel two LEDs or laser diode LD composition, the wavelength of a luminous tube is 830nm, the wavelength of another luminous tube is 690nm, is taken turns the near infrared light emission of two luminous tubes of current control different wave length by the microprocessor timesharing; The input of constant-current circuit is connected to set output terminal with microprocessor, is regulated the size of constant current by microprocessor.
6. brain function modulation according to claim 3 and the integrated apparatus that detects, it is characterized in that: transmitting probe and receiving transducer are elongated cylindrical, can conveniently insert the installation hole on the silica gel sheath, by the clamping of elastic silica gel hole, the degree of depth of scalable in hole is installed reaches the close contact with scalp.
7. brain function modulation according to claim 1 and 2 and the integrated apparatus that detects, it is characterized in that: the installation site is selected according to the needs that detect the position in the transmitting probe of Near-infrared Brain function optical imaging instrument and the installation position of receiving transducer, and keeping distance between the two is 3～5cm.
8. brain function modulation according to claim 4 and the integrated apparatus that detects, it is characterized in that: the bidirectional constant drive circuit in the described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and the constant-current circuit that is attached thereto, the outfan of bidirectional bridge type drive circuit directly drives the transmitting probe that two-way antiparallel two photosensitive tubes form, the wavelength of a light emitting diode is 830nm, a light emitting diode is 690nm, is taken turns the near infrared light emission of two photosensitive tubes of current control different wave length by the microprocessor timesharing; The input of constant-current circuit is connected to set output terminal with microprocessor.
9. brain function modulation according to claim 3 and the integrated apparatus that detects, it is characterized in that: the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are placed on respectively the overcoat (2c) of silica gel sheath and the probe of inner sleeve (2d) is installed in the hole, and the distance between transmitting probe and receiving transducer is 3-5cm.
10. brain function modulation according to claim 1 and 2 and the integrated apparatus that detects, it is characterized in that: the transmitting probe of Near-infrared Brain function optical imaging instrument is established 1～10,1～10 of receiving transducer; Probe diameter all is 2.5mm.
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