CN102921103B - Implantable visual prosthesis nerve stimulator - Google Patents
Implantable visual prosthesis nerve stimulator Download PDFInfo
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- CN102921103B CN102921103B CN201210402679.8A CN201210402679A CN102921103B CN 102921103 B CN102921103 B CN 102921103B CN 201210402679 A CN201210402679 A CN 201210402679A CN 102921103 B CN102921103 B CN 102921103B
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Abstract
The invention relates to an implantable visual prosthesis nerve stimulator, which comprises an extracorporal module for acquiring, processing, modulating, sending and storing external image information, an intracorporal implantation module for receiving energy and data information which are sent by the extracorporal module and drives an electrode to stimulate optic nerves by a microcurrent stimulator chip and a radio frequency identification percutaneous channel for transmitting energy and a signal to the intracorporal implantation module from the extracorporal module, wherein the extracorporal module comprises a high-order modulation circuit; and the microcurrent stimulator chip comprises an analog/digital mixing high-order demodulation circuit. According to the implantable visual prosthesis nerve stimulator, contradiction among the high transmission rate of data, high-efficiency transmission of the energy and the size of a coil in the prior art is avoided by utilizing a high-order system circuit, and the optimization of the high transmission rate of the data and the high-efficiency transmission of the energy is realized on the premise of reducing the size of the wireless transmission coil.
Description
Technical field
The invention belongs to biological doctor's electrical domain, relate to a kind of implanted vision prosthesis nerve stimulator repairing blind visual function.
Background technology
According to WHO Report, world vision disabled patient about has 1.4 hundred million, wherein blind person 45,000,000.China is the country that whole world blind person is maximum, and patient with visual disabilities nearly 1,300 ten thousand, wherein blind person about 5,500,000.In recent years, whole world scientist is being devoted to research, exploration vision prosthesis substitutes retinal function to repair the effective means of visual performance.Its principle utilizes vision prosthesis to gather external image information, carries out coded treatment, by micro-current stimulator to visual system effect, thus produces visual experience, i.e. phosphene at nerve centre, make blind person recover vision.
Implanted vision prosthesis kind based on different operating principle is a lot, but its element is substantially identical, mainly comprises: external information part and signal processing; Nerve stimulator and electrode part in body; Signal and energy delivery is carried out therebetween by radio frequency wireless transmission.In order to realize the inside and outside energy of body and signal wireless transmission, traditional method adopts twin coil coupling, and energy and data adopt the carrier wave of different frequency to transmit by respective coil.The method will certainly increase the volume of et al. Ke part on the one hand; There is mutual inductance interference between twin coil on the other hand, affect laser propagation effect.For overcoming twin coil transmission drawback, some research teams adopt unicoil same frequency carrier wave transferring energy and signal.But, new problem occurs again thereupon: for skin and the biological tissue wireless transmitting system as channel, and high frequency carrier is absorbed obviously by skin and biological tissue, therefore, realize the high-efficiency transfer of energy, it is desirable to adopt lower frequency to carry out transmission of power; And for data transmission, in order to obtain quality, high resolution visual effect, message transmission rate must be improved, it is desirable to adopt higher frequency to carry out the transmission of data.
Summary of the invention
The object of this invention is to provide a kind of implanted vision prosthesis nerve stimulator, solve the contradiction between the message transmission rate of prior art existence and energy transmission efficiency.
The technical solution adopted in the present invention is: implanted vision prosthesis nerve stimulator, comprise the external module of external image information collection, process, modulation, transmitting and storage, the energy that the outer module of receiving body sends and data message and by the et al. Ke module of micro-current stimulator chip drives electrode stimulating optic nerve, and by the radio communication percutaneous passage of described external module to described et al. Ke module transfer energy and signal; Described external module comprises high order modulation circuit, and described micro-current stimulator chip comprises modulus mixing high-order demodulator circuit.
Described external module is made up of the CMOS camera connected successively, video decoding circuit, dsp processor, high order modulation circuit, radio frequency transtation mission circuit and the memory element that is connected with dsp processor; Described CMOS camera gathers outside original image, the view data of conversion is sent to described dsp processor after described video decoding circuit process, the view data of collection is buffered in described memory element by described dsp processor again, modulate through the data message of described high order modulation circuit to dsp processor process, finally pass through radio communication percutaneous passage to described et al. Ke module transmission of power and view data simultaneously by described radio frequency transtation mission circuit.
Described et al. Ke module comprises energy acceptance circuit, data receiver circuit, rectification filtering voltage stabilizing circuit, microelectric current chip and electrode; Described energy acceptance circuit provides work required voltage through rectification filtering voltage stabilizing circuit to described micro-current stimulator chip, described data receiver circuit receives viewdata signal and generates Signal transmissions to described micro-current stimulator chip, and the signal received is converted to corresponding pulse signal drive electrode by described micro-current stimulator chip stimulates optic nerve to make blind person patient produce phosphene.
Described micro-current stimulator chip also comprises voltage adjuster, digital control circuit, digital to analog converter, electric charge elimination circuit and positive negative phase current pulse-generating circuit.
Described modulus mixing high-order demodulator circuit comprises sampling hold circuit, the mixting circuit be made up of neuron MOS devices, matched filtering circuit, differential decoderl, amplitude and phase place decision device; Input signal after described sampling hold circuit without the need to quantizing, directly with described carrier wave Cos ω
ct, Sin ω
cthe mixting circuit that the carrier wave that t produces circuit generation is formed via described neuron MOS devices carries out analog frequency mixing, the differential decoderl be made up of described neuron MOS devices after the matched filtering circuit filtering high-frequency signal that described neuron MOS devices is formed again completes differential decoding, the amplitude finally adopting described neuron MOS devices to form and phase place decision device carry out amplitude and phase place judgement, export corresponding digital demodulated signal.
The present invention has following beneficial effect:
1, the present invention utilizes high-order system circuit to solve the high transfer rate of data of prior art existence, the contradiction between the high efficiency of transmission of energy and winding volume three, reducing, under the long-pending prerequisite of wireless transmission coil case, to optimize while achieving the high transfer rate of data and the high efficiency of transmission two aspect performance of energy.
2, the introducing of high order modulation technique, complexity and the power consumption of demodulator circuit will certainly be increased, this is that vision prosthesis micro-current stimulator is undesirable, the present invention adopts modulus mixing demodulator circuit to realize the chip circuit of low-power consumption, by low-power consumption modulus mixing demodulator circuit, demodulate differential amplitude and phase place at receiving terminal, finally map out the data of modulation.
3, the present invention adopts low-power consumption modulus mixing demodulation, decreases device count, reduces circuit power consumption, and under achieving low carrier frequency, high efficiency energy transmits and high speed data transfer.
Accompanying drawing explanation
Fig. 1 is the system block diagram of vision prosthesis of the present invention;
Fig. 2 is micro-current stimulator chip internal structure block diagram of the present invention;
Fig. 3 is modulus mixing high-order demodulation schematic block circuit diagram of the present invention;
In figure, 1. external module, 2. et al. Ke module, 3. radio communication percutaneous passage, 4.CMOS photographic head, 5. video decoding circuit, 6.DSP processor, 7. high order modulation circuit, 8. radio frequency transtation mission circuit, 9. memory element, 10. energy acceptance circuit, 11. rectification filtering voltage stabilizing circuits, 12. data receiver circuits, 13. micro-current stimulator chips, 14. electrodes, 15. voltage adjuster 16. modulus mixing high-order demodulator circuits, 17. digital control circuits, 18. digital to analog converters, 19. electric charges eliminate circuit, 20. positive negative phase current pulse-generating circuits, 21. sampling hold circuits, 22. carrier wave Cos ω
ct produces circuit, 23. carrier wave Sin ω
ct produces circuit, the mixting circuit that 24. neuron MOS devices are formed, the matched filtering circuit that 25. neuron MOS devices are formed, the differential decoderl that 26. neuron MOS devices are formed, the amplitude that 27. neuron MOS devices are formed and phase place decision device.
Detailed description of the invention
Below in conjunction with the drawings and the specific embodiments, the present invention is described in detail.
Implanted vision prosthesis nerve (micro-electric current) stimulator.As shown in Figure 1, be made up of external module 1, et al. Ke module 2 and radio communication percutaneous passage 3.External module 1 comprises CMOS camera 4, video decoding circuit 5, dsp processor 6, high order modulation circuit (MDAPSK) 7, radio frequency transmitter circuitry 8 and memory element (SDRAM) 9.CMOS camera 4 gathers outside original image, the view data of conversion is sent to dsp processor 6 after video decoding circuit 5 processes, the view data of collection is buffered in memory element (SDRAM) 9 by dsp processor 6 again, after high order modulation circuit (MDAPSK) 7 is modulated, pass through radio communication percutaneous passage 3 to et al. Ke module 2 transmission of power and view data simultaneously by radio frequency transtation mission circuit 8.Et al. Ke module 2 comprises energy acceptance circuit 10, rectification filtering voltage stabilizing circuit 11, data receiver circuit 12, micro-current stimulator chip 13 and some electrodes 14.Energy acceptance circuit 10 and rectification filtering voltage stabilizing circuit subsequently 11 are responsible for providing work required voltage V to micro-current stimulator chip 13
dD, data receiver circuit 12 is responsible for receiving viewdata signal and generating signal V
sigbe transferred to micro-current stimulator chip 13.The signal received is converted to corresponding pulse signal drive electrode 14 by micro-current stimulator chip 13 stimulates optic nerve to make blind person patient produce phosphene.
Micro-current stimulator chip 13 internal structure as shown in Figure 2, it is a modulus hydrid integrated circuit, comprise voltage adjuster 15, modulus mixing high-order demodulator circuit 16, digital control circuit 17, digital to analog converter (DAC) 18, electric charge eliminates circuit 19 and positive negative phase current pulse-generating circuit 20.
Consider that in percutaneous channel, skin and biological tissue are on the impact of wireless radio frequency transmission signal, utilize high order modulation circuit (MDAPSK) 7 to solve the contradiction of the high transfer rate of data in vision prosthesis micro-current stimulator, the high efficiency of transmission of energy and winding volume three.But, the introducing of high order modulation technique, complexity and the power consumption of modulation-demodulation circuit will certainly be increased, this is that vision prosthesis micro-current stimulator is undesirable, therefore the present invention is special to be applied to the Analog-digital circuit structure be made up of neuron MOS devices in high-order demodulator circuit 16 thus to realize low-power chip circuit design, modulus mixing high-order demodulation inside circuit theory diagram as shown in Figure 3, comprises sampling hold circuit 21, carrier wave Cos ω
ct produces circuit 22, carrier wave Sin ω
ct produces circuit 23, the mixting circuit 24 that neuron MOS devices is formed, the matched filtering circuit 25 that neuron MOS devices is formed, the differential decoderl 26 that neuron MOS devices is formed, the amplitude that neuron MOS devices is formed and phase place decision device 27.Input signal after sampling hold circuit 21 without the need to quantizing, directly and carrier wave Cos ω
ct produces circuit 22, carrier wave Sin ω
cmixting circuit 24 analog frequency mixing that the carrier wave that t produces circuit 23 generation is formed via neuron MOS devices, the differential decoderl 26 be made up of neuron MOS devices after the matched filtering circuit 25 filtering high-frequency signal that neuron MOS devices is formed completes differential decoding, the amplitude finally adopting neuron MOS devices to form and phase place decision device 27 carry out amplitude and phase place judgement, export corresponding digital demodulated signal (D
nd
0).
Adopt the modulus mixing demodulator circuit (16) be made up of neuron MOS devices, A/D changer can be saved, replace complicated digital signal processing algorithm with the computing of walk-off-mode analog quantity simultaneously, number of circuit elements will be saved in a large number, reduce circuit power consumption, for the high-order demodulation circuit realiration of low-power consumption provides a kind of new approach.
Claims (2)
1. implanted vision prosthesis nerve stimulator, it is characterized in that: comprise the external module (1) of external image information collection, process, modulation, transmitting and storage, the energy that the outer module (1) of receiving body sends and data message and stimulated the et al. Ke module (2) of optic nerve by micro-current stimulator chip (13) drive electrode, and by the radio communication percutaneous passage (3) of external module (1) to et al. Ke module (2) transmission of power and signal; Described external module (1) comprises high order modulation circuit (7), and described micro-current stimulator chip (13) comprises modulus mixing high-order demodulator circuit (16);
Described external module (1) is made up of the CMOS camera connected successively (4), video decoding circuit (5), dsp processor (6), high order modulation circuit (7), radio frequency transtation mission circuit (8) and the memory element (9) that is connected with dsp processor (6); Described CMOS camera (4) gathers outside original image, the view data of conversion is sent to described dsp processor (6) after described video decoding circuit (5) process, the view data of collection is buffered in described memory element (9) by described dsp processor (6) again, through described high order modulation circuit (7), dsp processor reduced data information is modulated, finally by described radio frequency transtation mission circuit (8) by radio communication percutaneous passage (3) to described et al. Ke module (2) transmission of power and view data simultaneously;
Described et al. Ke module (2) comprises energy acceptance circuit (10), data receiver circuit (12), rectification filtering voltage stabilizing circuit (11), described microelectric current chip (13) and electrode (14); Described energy acceptance circuit (10) provides work required voltage through rectification filtering voltage stabilizing circuit (11) to described micro-current stimulator chip (13), described data receiver circuit (12) receives viewdata signal and generates Signal transmissions to described micro-current stimulator chip (13), and the signal received is converted to corresponding pulse signal drive electrode (14) by described micro-current stimulator chip (13) stimulates optic nerve to make blind person patient produce phosphene;
Described modulus mixing high-order demodulator circuit (16) comprises sampling hold circuit (21), carrier wave Cos ω
ct produces circuit (22), carrier wave Sin ω
ct produces circuit (23), the mixting circuit (24) that neuron MOS devices is formed, the matched filtering circuit (25) that neuron MOS devices is formed, the differential decoderl (26) that neuron MOS devices is formed, the amplitude that neuron MOS devices is formed and phase place decision device (27); Input data without the need to quantizing after described sampling hold circuit (21), direct and carrier wave Cos ω
ct produces circuit (22), carrier wave Sin ω
cmixting circuit (24) analog frequency mixing that the carrier wave that t generation circuit (23) produces is formed via neuron MOS devices, the differential decoderl (26) be made up of neuron MOS devices after matched filtering circuit (25) the filtering high-frequency signal that neuron MOS devices is formed completes differential decoding, the amplitude finally adopting neuron MOS devices to form and phase place decision device (27) carry out amplitude and phase place judgement, export corresponding digital demodulated signal (D
nd
0).
2. implanted vision prosthesis nerve stimulator as claimed in claim 1, is characterized in that: described micro-current stimulator chip also comprises voltage adjuster (15), digital control circuit (17), digital to analog converter (18), electric charge elimination circuit (19) and positive negative phase current pulse-generating circuit (20).
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| CN201210402679.8A CN102921103B (en) | 2012-10-19 | 2012-10-19 | Implantable visual prosthesis nerve stimulator |
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| CN201210402679.8A CN102921103B (en) | 2012-10-19 | 2012-10-19 | Implantable visual prosthesis nerve stimulator |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496643B (en) * | 2016-01-18 | 2017-05-31 | 戴国群 | Acquired blindness patient visual recovers lost eyesight intelligent object wearing device and its manufacture method |
| CN109960182A (en) * | 2017-12-22 | 2019-07-02 | 深圳市上示科技有限公司 | A kind of signal generation apparatus and the equipment with signal generation apparatus |
| CN210121293U (en) * | 2017-12-29 | 2020-03-03 | 深圳硅基仿生科技有限公司 | Radio frequency signal detection device and retina stimulator |
| CN108653917A (en) * | 2018-05-17 | 2018-10-16 | 郑州大学 | Biological sensing capability based on nerve electric stimulation enhances system |
| WO2021102733A1 (en) * | 2019-11-27 | 2021-06-03 | 深圳先进技术研究院 | Visual prosthesis apparatus and system, control method and related device |
| CN111488958A (en) * | 2020-04-13 | 2020-08-04 | 中国医学科学院北京协和医院 | Artificial prosthesis information tracking and collecting system and method based on intelligent chip |
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| US5935155A (en) * | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
| CN102258409A (en) * | 2011-04-20 | 2011-11-30 | 上海交通大学 | Wireless energy and data transmission system for visual prosthesis |
| CN102509283A (en) * | 2011-09-30 | 2012-06-20 | 西安理工大学 | DSP (digital signal processor)-based target perceiving and encoding method facing optic nerve prosthesis |
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| US5935155A (en) * | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
| CN102258409A (en) * | 2011-04-20 | 2011-11-30 | 上海交通大学 | Wireless energy and data transmission system for visual prosthesis |
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| MDAPSK调制解调技术研究及FPGA实现;朱智明;《中国优秀硕士论文数据库信息科技辑》;20090415(第4期);第1页第1段、第6页第2段、第14页第2段-第17页第2段，及图2-17 * |
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