CN102921103A - Implantable visual prosthesis nerve stimulator - Google Patents
Implantable visual prosthesis nerve stimulator Download PDFInfo
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- CN102921103A CN102921103A CN2012104026798A CN201210402679A CN102921103A CN 102921103 A CN102921103 A CN 102921103A CN 2012104026798 A CN2012104026798 A CN 2012104026798A CN 201210402679 A CN201210402679 A CN 201210402679A CN 102921103 A CN102921103 A CN 102921103A
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Abstract
The invention relates to an implantable visual prosthesis nerve stimulator, which comprises an extracorporal module for acquiring, processing, modulating, sending and storing external image information, an intracorporal implantation module for receiving energy and data information which are sent by the extracorporal module and drives an electrode to stimulate optic nerves by a microcurrent stimulator chip and a radio frequency identification percutaneous channel for transmitting energy and a signal to the intracorporal implantation module from the extracorporal module, wherein the extracorporal module comprises a high-order modulation circuit; and the microcurrent stimulator chip comprises an analog/digital mixing high-order demodulation circuit. According to the implantable visual prosthesis nerve stimulator, contradiction among the high transmission rate of data, high-efficiency transmission of the energy and the size of a coil in the prior art is avoided by utilizing a high-order system circuit, and the optimization of the high transmission rate of the data and the high-efficiency transmission of the energy is realized on the premise of reducing the size of the wireless transmission coil.
Description
Technical field
The invention belongs to biological doctor's electrical domain, relate to a kind of implanted vision prosthesis nerve stimulator of repairing the blind visual function.
Background technology
According to World Health Organization's report, the world vision disabled patient has 1.4 hundred million approximately, and wherein the blind person 4,500 ten thousand.China is the maximum country of whole world blind person, and patient with visual disabilities is nearly 1,300 ten thousand, and wherein the blind person about 5,500,000.In recent years, whole world scientist is being devoted to study, explore the effective means of repairing visual performance with the alternative retinal function of vision prosthesis.Its principle is to utilize vision prosthesis to gather external image information, processings of encoding, by micro-current stimulator to the visual system effect, thereby at nerve centre generation visual experience, namely phosphene makes the blind person recover vision.
Implanted vision prosthesis kind based on the different operating principle is a lot, but its element is substantially identical, mainly comprises: external information part and signal processing; Nerve stimulator and electrode part in the body; Carry out signal and energy delivery by the wireless radiofrequency transmission therebetween.For the energy and the signal wireless transmission that realize that body is inside and outside, traditional method adopts the twin coil coupling, and the coil that energy and data communication device are crossed separately adopts the carrier wave of different frequency to transmit.The method will certainly increase the volume that body is implanted into part on the one hand; Exist on the other hand mutual inductance to disturb between the twin coil, affect laser propagation effect.For overcoming twin coil transmission drawback, some research teams adopt unicoil same frequency carrier wave transferring energy and signal.But, new problem occurs again thereupon: for skin and the biological tissue wireless transmitting system as channel, high frequency carrier is absorbed obviously by skin and biological tissue, therefore, realize the high-efficiency transfer of energy, wish to adopt lower frequency to come transmission of power; And for transfer of data, in order to obtain the quality, high resolution visual effect, must improve message transmission rate, wish to adopt higher frequency to carry out data transfer.
Summary of the invention
The purpose of this invention is to provide a kind of implanted vision prosthesis nerve stimulator, solve the message transmission rate of prior art existence and the contradiction between the energy transmission efficiency.
The technical solution adopted in the present invention is: implanted vision prosthesis nerve stimulator, comprise the external module with external image information gathering, processing, modulation, emission and storage, receive energy that external module sends and data message and the body by micro-current stimulator chip drives electrode stimulating optic nerve is implanted into module, and be implanted into the less radio-frequency percutaneous channel of module transmission of power and signal by described external module to described body; Described external module comprises the high order modulation circuit, and described micro-current stimulator chip comprises modulus and mixes the higher-order solutions demodulation circuit.
Described external module is connected to form by CMOS photographic head, video decode circuit, dsp processor, high order modulation circuit, radio frequency transtation mission circuit and memory element successively; The outside original image of described CMOS camera collection, view data with conversion after described video decode processing of circuit sends described dsp processor to, described dsp processor is buffered in the view data that gathers in the described memory element again, modulate through the data message that described high order modulation circuit was processed dsp processor, be implanted into module simultaneously transmission of power and view data by radio communication percutaneous passage to described body by described radio frequency transtation mission circuit at last.
Described body is implanted into module and comprises energy receiving circuit, data receiver circuit, rectification filtering voltage stabilizing circuit, microelectric current chip and electrode; Described energy receiving circuit and rectification filtering voltage stabilizing circuit provide the work required voltage to described micro-current stimulator chip, described data receiver circuit receives viewdata signal and generates signal and is transferred to described micro-current stimulator chip, and described micro-current stimulator chip converts the signal that receives to corresponding pulse signal drive electrode stimulates optic nerve to make blind person patient produce phosphene.
Described micro-current stimulator chip also comprises voltage adjuster, digital control circuit, digital to analog converter, electric charge elimination circuit and positive and negative phase current pulse-generating circuit.
Described modulus mixes mixting circuit, matched filtering circuit, differential decoderl, amplitude and the phase place decision device that the higher-order solutions demodulation circuit comprises sampling hold circuit, is made of neuron MOS devices; Input signal need not to quantize behind described sampling hold circuit, directly with described carrier wave Cos ω
cT, Sin ω
cThe carrier wave that t produces the circuit generation carries out analog frequency mixing via the mixting circuit that described neuron MOS devices consists of, the differential decoderl that is made of described neuron MOS devices after the matched filtering circuit filtering high-frequency signal that described neuron MOS devices consists of is again finished differential decoding, the amplitude and the phase place decision device that adopt at last described neuron MOS devices to consist of carry out amplitude and phase place judgement, the digital demodulation signal that output is corresponding.
The present invention has following beneficial effect:
1, the present invention utilizes high-order system circuit to solve high transfer rate, the high efficiency of transmission of energy and the contradiction between the winding volume three of the data of prior art existence, reducing under the long-pending prerequisite of wireless transmission coil case, optimizing when having realized the high efficiency of transmission two aspect performances of the high transfer rate of data and energy.
2, the introducing of high order modulation technology, will certainly increase complexity and the power consumption of demodulator circuit, this is that the vision prosthesis micro-current stimulator is undesirable, the present invention adopts modulus mixing demodulator circuit to realize the chip circuit of low-power consumption, by low-power consumption modulus mixing demodulator circuit, demodulate differential amplitude and phase place at receiving terminal, finally map out the data of modulation.
3, the present invention adopts low-power consumption modulus mixing demodulation, has reduced device count, has reduced circuit power consumption, has realized high efficiency energy transmission and high speed data transfer under the low carrier frequency.
Description of drawings
Fig. 1 is the system block diagram of vision prosthesis of the present invention;
Fig. 2 is micro-current stimulator chip internal structure block diagram of the present invention;
Fig. 3 is that modulus of the present invention mixes higher-order solutions demodulation circuit theory diagram;
Among the figure, 1. external module, 2. body is implanted into module, 3. radio communication percutaneous passage, 4.CMOS photographic head, 5. video decode circuit, 6.DSP processor, 7. high order modulation circuit, 8. radio frequency transtation mission circuit, 9. memory element, 10. energy receiving circuit, 11. rectification filtering voltage stabilizing circuit, 12. data receiver circuits, 13. micro-current stimulator chips, 14. electrode, 15. voltage adjuster 16. moduluses mix higher-order solutions demodulation circuit, 17. digital control circuits, 18. digital to analog converters, 19. electric charge is eliminated circuit, 20. positive and negative phase current pulse-generating circuit, 21. sampling hold circuits, 22. carrier wave Cos ω
cT produces circuit, 23. carrier wave Sin ω
cT produces circuit, the mixting circuit that 24. neuron MOS devices consist of, the matched filtering circuit that 25. neuron MOS devices consist of, the differential decoderl that 26. neuron MOS devices consist of, amplitude and phase place decision device that 27. neuron MOS devices consist of.
The specific embodiment
The present invention is described in detail below in conjunction with the drawings and the specific embodiments.
Neural (little electric current) stimulator of implanted vision prosthesis.As shown in Figure 1, be implanted into module 2 by external module 1, body and radio communication percutaneous passage 3 forms.External module 1 comprises CMOS photographic head 4, video decode circuit 5, dsp processor 6, high order modulation circuit (MDAPSK) 7, radio-frequency transmissions circuit 8 and memory element (SDRAM) 9.CMOS photographic head 4 gathers outside original image, view data with conversion after video decode circuit 5 is processed sends dsp processor 6 to, dsp processor 6 is buffered in the view data that gathers in the memory element (SDRAM) 9 again, is implanted into module 2 simultaneously transmission of power and view data by radio communication percutaneous passage 3 to body by radio frequency transtation mission circuit 8 after high order modulation circuit (MDAPSK) 7 modulation.Body is implanted into module 2 and comprises energy receiving circuit 10, rectification filtering voltage stabilizing circuit 11, data receiver circuit 12, micro-current stimulator chip 13 and some electrodes 14.Energy receiving circuit 10 and rectification filtering voltage stabilizing circuit subsequently 11 are responsible for providing work required voltage V to micro-current stimulator chip 13
DD, data receiver circuit 12 is responsible for receiving viewdata signal and generating signal V
SigBe transferred to micro-current stimulator chip 13.Micro-current stimulator chip 13 converts the signal that receives to corresponding pulse signal drive electrode 14 stimulates optic nerve to make blind person patient produce phosphene.
Consider that skin and biological tissue utilize high order modulation circuit (MDAPSK) 7 to solve high transfer rate, the high efficiency of transmission of energy and winding volume three's the contradiction of data in the vision prosthesis micro-current stimulators on the impact of wireless radio frequency transmission signal in the percutaneous channel.Yet, the introducing of high order modulation technology, will certainly increase complexity and the power consumption of modulation-demodulation circuit, this is that the vision prosthesis micro-current stimulator is undesirable, therefore thereby spy of the present invention will be applied to by the modulus hybrid circuit structure that neuron MOS devices consists of and realize the low-power chip circuit design in the higher-order solutions demodulation circuit 16, modulus mixes the inner theory diagram of higher-order solutions demodulation circuit as shown in Figure 3, comprises sampling hold circuit 21, carrier wave Cos ω
cT produces circuit 22, carrier wave Sin ω
cT produces circuit 23, the mixting circuit 24 that neuron MOS devices consists of, the matched filtering circuit 25 that neuron MOS devices consists of, the differential decoderl 26 that neuron MOS devices consists of, amplitude and phase place decision device 27 that neuron MOS devices consists of.Input signal need not to quantize behind sampling hold circuit 21, direct and carrier wave Cos ω
cT produces circuit 22, carrier wave Sin ω
cT produces the carrier wave of circuit 23 generations via mixting circuit 24 analog frequency mixings of neuron MOS devices formation, the differential decoderl 26 that is made of neuron MOS devices after the matched filtering circuit 25 filtering high-frequency signals that neuron MOS devices consists of is finished differential decoding, the amplitude and the phase place decision device 27 that adopt at last neuron MOS devices to consist of carry out amplitude and phase place judgement, the digital demodulation signal (D that output is corresponding
nD
0).
The modulus mixing demodulator circuit (16) that employing is made of neuron MOS devices, can save the A/D changer, the simultaneously computing with the discrete analog(ue) amount replaces complicated digital signal processing algorithm, to save in a large number number of circuit elements, reduce circuit power consumption, for the higher-order solutions demodulation circuit of low-power consumption realizes providing a kind of new approach.
Claims (5)
1. implanted vision prosthesis nerve stimulator, it is characterized in that: comprise the external module (1) with external image information gathering, processing, modulation, emission and storage, receive energy that external module (1) sends and data message and stimulate the body of optic nerve to be implanted into module (2) by micro-current stimulator chip (13) drive electrode, reach the less radio-frequency percutaneous channel (3) that is implanted into module (2) transmission of power and signal by external module (1) to body; Described external module (1) comprises high order modulation circuit (7), and described micro-current stimulator chip (13) comprises modulus and mixes higher-order solutions demodulation circuit (16).
2. implanted vision prosthesis nerve stimulator as claimed in claim 1, it is characterized in that: described external module (1) is connected to form by CMOS photographic head (4), video decode circuit (5), dsp processor (6), high order modulation circuit (7), radio frequency transtation mission circuit (8) and memory element (9) successively; Described CMOS photographic head (4) gathers outside original image, view data with conversion after described video decode circuit (5) is processed sends described dsp processor (6) to, described dsp processor (6) is buffered in the view data that gathers in the described memory element (9) again, through described high order modulation circuit (7) dsp processor reduced data information is modulated, be implanted into module (2) simultaneously transmission of power and view data by radio communication percutaneous passage (3) to described body by described radio frequency transtation mission circuit (8) at last.
3. implanted vision prosthesis nerve stimulator as claimed in claim 1 or 2, it is characterized in that: described body is implanted into module (2) and comprises energy receiving circuit (10), data receiver circuit (12), rectification filtering voltage stabilizing circuit (11), described microelectric current chip (13) and electrode (14); Described energy receiving circuit (10) and rectification filtering voltage stabilizing circuit (11) provide the work required voltage to described micro-current stimulator chip (13), described data receiver circuit (12) receives viewdata signal and generates signal and is transferred to described micro-current stimulator chip (13), and described micro-current stimulator chip (13) converts the signal that receives to corresponding pulse signal drive electrode (14) stimulates optic nerve to make blind person patient produce phosphene.
4. implanted vision prosthesis nerve stimulator as claimed in claim 1 or 2 is characterized in that: described micro-current stimulator chip comprises that also voltage adjuster (15), digital control circuit (17), digital to analog converter (18), electric charge eliminate circuit (19) and positive and negative phase current pulse-generating circuit (20).
5. implanted vision prosthesis nerve stimulator as claimed in claim 1 or 2 is characterized in that: described modulus mixes higher-order solutions demodulation circuit (16) and comprises sampling hold circuit (21), carrier wave Cos ω
cT produces circuit (22), carrier wave Sin ω
cT produces circuit (23), the mixting circuit (24) that neuron MOS devices consists of, the matched filtering circuit (25) that neuron MOS devices consists of, the differential decoderl (26) that neuron MOS devices consists of, amplitude and phase place decision device (27) that neuron MOS devices consists of; The input data need not to quantize behind described sampling hold circuit (21), direct and carrier wave Cos ω
cT produces circuit (22), carrier wave Sin ω
cT produces the carrier wave of circuit (23) generation via mixting circuit (24) analog frequency mixing of neuron MOS devices formation, the differential decoderl (26) that is made of neuron MOS devices after matched filtering circuit (25) the filtering high-frequency signal that neuron MOS devices consists of is finished differential decoding, the amplitude and the phase place decision device (27) that adopt at last neuron MOS devices to consist of carry out amplitude and phase place judgement, the digital demodulation signal (D that output is corresponding
nD
0).
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Cited By (6)
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| CN105496643A (en) * | 2016-01-18 | 2016-04-20 | 戴国群 | Intelligent wearing device for vision recovery of patient with posteriority blindness and making method thereof |
| CN108653917A (en) * | 2018-05-17 | 2018-10-16 | 郑州大学 | Biological sensing capability based on nerve electric stimulation enhances system |
| CN109701157A (en) * | 2017-12-29 | 2019-05-03 | 深圳硅基仿生科技有限公司 | Radio-frequency signal detection device and retina stimulator with detection coil |
| CN109960182A (en) * | 2017-12-22 | 2019-07-02 | 深圳市上示科技有限公司 | A kind of signal generation apparatus and the equipment with signal generation apparatus |
| CN111488958A (en) * | 2020-04-13 | 2020-08-04 | 中国医学科学院北京协和医院 | Artificial prosthesis information tracking and collecting system and method based on intelligent chip |
| WO2021102733A1 (en) * | 2019-11-27 | 2021-06-03 | 深圳先进技术研究院 | Visual prosthesis apparatus and system, control method and related device |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496643A (en) * | 2016-01-18 | 2016-04-20 | 戴国群 | Intelligent wearing device for vision recovery of patient with posteriority blindness and making method thereof |
| CN105496643B (en) * | 2016-01-18 | 2017-05-31 | 戴国群 | Acquired blindness patient visual recovers lost eyesight intelligent object wearing device and its manufacture method |
| CN109960182A (en) * | 2017-12-22 | 2019-07-02 | 深圳市上示科技有限公司 | A kind of signal generation apparatus and the equipment with signal generation apparatus |
| CN109701157A (en) * | 2017-12-29 | 2019-05-03 | 深圳硅基仿生科技有限公司 | Radio-frequency signal detection device and retina stimulator with detection coil |
| CN110548224A (en) * | 2017-12-29 | 2019-12-10 | 深圳硅基仿生科技有限公司 | Radio frequency signal detection device and retina stimulator |
| CN110548225A (en) * | 2017-12-29 | 2019-12-10 | 深圳硅基仿生科技有限公司 | Radio frequency signal detection device and retina stimulator |
| CN110548224B (en) * | 2017-12-29 | 2021-07-20 | 深圳硅基仿生科技有限公司 | Radio frequency signal detection device and retina stimulator |
| CN108653917A (en) * | 2018-05-17 | 2018-10-16 | 郑州大学 | Biological sensing capability based on nerve electric stimulation enhances system |
| WO2021102733A1 (en) * | 2019-11-27 | 2021-06-03 | 深圳先进技术研究院 | Visual prosthesis apparatus and system, control method and related device |
| CN111488958A (en) * | 2020-04-13 | 2020-08-04 | 中国医学科学院北京协和医院 | Artificial prosthesis information tracking and collecting system and method based on intelligent chip |
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