CN102883682A - 调节眼内晶状体的装置 - Google Patents
调节眼内晶状体的装置 Download PDFInfo
- Publication number
- CN102883682A CN102883682A CN201180021257XA CN201180021257A CN102883682A CN 102883682 A CN102883682 A CN 102883682A CN 201180021257X A CN201180021257X A CN 201180021257XA CN 201180021257 A CN201180021257 A CN 201180021257A CN 102883682 A CN102883682 A CN 102883682A
- Authority
- CN
- China
- Prior art keywords
- optical element
- iol device
- modulability
- eyes
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/1682—Intraocular lenses having supporting structure for lens, e.g. haptics having mechanical force transfer mechanism to the lens, e.g. for accommodating lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/16901—Supporting structure conforms to shape of capsular bag
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
Abstract
适于植入对象眼睛的晶状体囊内的调节性眼内晶状体(IOL)装置。IOL装置包括在前折射光学元件和连接至折射光学元件的膜。在前折射光学元件和膜限定配置以包含流体的封闭腔。至少一部分膜被配置来接触邻接对象眼睛的玻璃体的晶状体囊的在后区域。包含在封闭腔内的流体响应由玻璃体在膜上施加的向前的力,对在前折射光学元件施加变形或位移力。IOL装置可进一步包括触觉系统以定位在前折射光学元件,并且还接合小带和睫状肌,从而提供用于调节的其它方式。
Description
发明领域
本发明一般地涉及调节眼内晶状体的装置,并且更具体地涉及配置用于植入患者眼睛的晶状体囊内的调节眼内晶状体的装置。
背景
白内障是影响视力的眼睛内晶状体的混浊。尽管大多数白内障与老化有关,但是白内障还可能由于外伤性眼睛损伤、青光眼、糖尿病、类固醇使用和暴露于辐射——仅举几个例子——而显现。如果不治疗,白内障将发展为最终的视力损失并且甚至完全失明。
一般通过外科手术去除混浊的晶状体基质并且在剩下的晶状体囊内植入替代人工眼内晶状体(IOL)治疗白内障。第一代植入的IOL装置包括单焦点晶状体(monofocal lens),其仅在单个距离上提供视力矫正。因此,尽管单焦点晶状体提供距离视觉,但是对于阅读仍需要矫正晶状体。
引入用于IOL装置的多焦点晶状体(multifocal lens)以在多于一个距离处提供视力矫正,目的是避免对于单焦点晶状体要求的另外的矫正晶状体的需要。多焦点晶状体一般具有不同折射能力的区域以在多个距离(例如,在近处、在中间位置和在远处)处提供视觉。多焦点晶状体的一个显著的劣势是视物变形的可能——特别是在晚上在光源附近以闪光和光晕的形式。
最近,已经引入调节性IOL装置作为用于白内障外科手术中的另一可选IOL。调节性IOL装置一般以单焦点晶状体为特征,所述单焦点晶状体配置以响应眼睛的自然调节机制在眼睛内向前和向后移动,从而允许眼睛聚焦在横跨宽范围距离的物体上。目前,Bausch and Lomb的是美国市场上唯一FDA-认证的调节性IOL。该装置包括相对平的中心晶状体和一对从中心晶状体突出的铰合触觉(hingedhaptics)。触觉响应眼睛的睫状肌的收缩和放松在眼睛内向前和向后移动中心晶状体部分,以提供不同能力的屈光度。装置单独依靠眼睛的睫状肌作用,以提供调节。而且,因为装置的外形大体上比自然晶状体囊的小,所以在植入该装置后,在该装置附近自然晶状体囊收缩。当自然晶状体囊收缩时,小带进一步从睫状肌伸展,伴随眼睛的可调节范围的附带损失。
为了提供更接近眼睛的自然范围的更宽范围的调节,已经开发了双晶状体IOL装置。双晶状体IOL装置一般以处于分隔关系的在前和在后晶状体为特征,并且单独依靠睫状肌同时促使在前和在后晶状体更近或更远,以改变它们之间的距离。在前和在后晶状体之间的不同距离提供调节。双晶状体IOL装置的实例包括1994年1月4日授予Sarfarazi的美国专利号5,275,623和2006年8月10日出版的Zadno-Azizi等人的美国公开号2006/0178741。双晶状体IOL装置一般具有的劣势是设计上更复杂并且需要眼睛内的更大切口用于植入。尽管双晶状体IOL装置可拥有提供更大范围调节的潜能,但是它们表现出与眼睛的自然晶状体结构的彻底背离。
尽管调节性IOL装置拥有更完全地恢复白内障患者的自然范围的视力的前景,但是它们仍未能充分地模仿眼睛的自然调节机制。这主要是因为它们单独依靠眼睛的睫状肌提供调节并且未能响应影响自然调节过程的其它力。
发明简述
通过不仅响应睫状肌的收缩/放松而且响应向前膨出并且向前施加力以改变晶状体囊的曲率的粘性体(viscous body)的影响,本文公开的调节眼内晶状体(IOL)装置的优选实施方式大体上模仿眼睛的自然调节机制。因此,通过提供双向位移和曲率上的变化,本文公开的调节性IOL装置提供更宽范围的调节——其接近于自然眼睛中发现的那些范围。
在一个实施方式中,描述了适用于植入对象眼睛的晶状体囊内的调节性IOL装置。调节性IOL装置包括具有折射光学元件的在前部分、弹性在后部分;以及在前部分和在后部分之间限定的封闭腔。封闭腔被配置来包含一定量的流体以隔开在前部分和在后部分。在后部分被配置来接触晶状体囊(lens bag)的在后部分(植入之后在晶状体囊(lenscapsule)的收缩之前),其在IOL装置被植入眼睛内并且腔包含流体时又至少在光轴和光轴周围区域内接触玻璃体。在后部分响应由玻璃体施加的向前的力动作,引起流体对折射光学元件施加变形力或位移力。
根据该实施方式的第一方面,折射光学元件响应向前的力增加它的曲率并且在没有向前的力的情况下减少曲率。
根据该实施方式的第二方面,弹性地偏置折射光学元件以使它的曲率基本上等于对象的自然晶状体囊的在前部分的曲率。
根据该实施方式的第三方面,IOL装置被偏置为这样的构造:其宽度基本上等于沿着光轴的未调节的自然晶状体囊的宽度。
根据该实施方式的第四方面,IOL装置的赤道部直径(equatorialdiameter)基本上等于未调节状态的对象的自然晶状体囊的赤道部直径。
根据该实施方式的第五方面,在前部分被制成一定大小以当IOL装置植入患者的眼睛内时接合(engage)小带。
根据该实施方式的第六方面,IOL装置进一步包括连接至在前部分的触觉系统。可配置触觉系统以当植入对象的眼睛内时基本上使折射光学元件在光轴的路径上居中。可选地或此外,配置触觉系统以当IOL装置植入对象的眼睛内时响应睫状肌的收缩和放松沿着光轴双向移动折射光学元件。
根据该实施方式的第七方面,腔内包含的流体的体积足以沿着光轴以距离d3——其基本上等于处于未调节状态沿着光轴的对象的自然晶状体囊的宽度d2——隔开在前和在后部分。
在另一实施方式中,描述了适合于植入对象眼睛的晶状体囊内的调节性IOL装置。调节性IOL装置包括在前折射光学元件以及包括在后表面的膜。膜被连接至在前的光学元件并限定配置以包含一定量流体的封闭腔。在后部分被配置来接触晶状体囊的在后部分,其当IOL装置植入眼睛内并且腔包含流体时又至少在光轴和光轴周围的区域内接触玻璃体。流体响应由玻璃体对在后表面施加的向前的力使在前折射光学元件变形。
根据该实施方式的第一方面,在前光学元件进一步包括自封阀,以允许流体的注入。
根据该实施方式的第二方面,所述流体是粘弹性的。
根据该实施方式的第三方面,所述流体是盐水或透明质酸的水溶液。
根据该实施方式的第四方面,所述流体具有与玻璃体液基本相同的粘度。
根据该实施方式的第五方面,所述流体具有与房水或玻璃体液基本相同的折射率。
根据该实施方式的第六方面,所述膜围绕在前折射光学元件的周围被连接至在前折射光学元件。
根据该实施方式的第七方面,所述在前折射光学元件包含在所述膜的封闭腔内。
根据该实施方式的第八方面,所述在后部分进一步包括加固部分。
在进一步的实施方式中,描述了用于在对象的眼睛内植入调节性眼内调节性晶状体(IOL)装置的方法。该方法包括通过对象眼睛内的切口在对象眼睛的晶状体囊中引入IOL装置,其中IOL装置包括连接至弹性膜以限定内腔的折射光学元件;定位对象眼睛的晶状体囊内的IOL装置以基本上使折射光学元件沿着光轴居中;并且将一定量流体注入至IOL装置的内腔,其足以引起弹性膜接触晶状体囊的在后部分,晶状体囊的在后部分至少在光轴和光轴周围的区域内又接触玻璃体。
由以下详述,所述优选实施方式的其它目标、特征和优势将对于本领域技术人员变得明显。但是,应当理解,详述和具体实例——虽然表明本发明的优选实施方式——通过阐述给出并且是非限制性的。在不脱离本发明精神的情况下可作出在本发明范围内的许多改变和改进,并且本发明包括所有这种改进。
附图简述
通过参照附图可更容易地理解本发明的优选和非限制性实施方式,其中:
图1A和1B是图解分别具有未调节状态和调节状态的晶状体的人眼的一些解剖学特征的截面图。
图2A、2B和2C分别是连接至流体-填充的晶状体囊的折射光学元件的实施方式的剖面透视图、平面图和横截面图。
图3A和3B分别是折射光学元件和触觉系统的实施方式的平面图和侧视图。
图4A、4B和4C分别是连接至流体填充的晶状体囊的图3A-B折射光学元件和触觉系统的实施方式的剖面透视图、平面图和横截面图。
图5A和5B分别是折射光学元件和触觉系统的另一实施方式的平面图和侧视图。
图6A、6B和6C分别是连接至流体-填充的晶状体囊的图5A-B折射光学元件和触觉系统的另一实施方式的剖面透视图、平面图和横截面图。
图7描绘了植入人眼的后房内的眼内晶状体装置的实施方式。
贯穿附图的几个视图,相似数字指相似部分。
优选的实施方式的详述
现在将参照附图描述本发明的具体、非限制性实施方式。应当理解,这种实施方式仅是例如并且仅说明了只是本发明范围内的少量实施方式。对于本领域技术人员显而易见的属于本发明的各种改变和改进被认为在本发明的精神、范围和考虑内,如所附权利要求书中进一步限定的。
如图1A-B中显示的,人眼100包括三个流体室:前房112、后房120和玻璃体房160。前房112大体上对应于角膜110和虹膜114之间的空间,而后房120大体上对应于由虹膜114、晶状体130和连接至晶状体130周围的小带纤维140限定的空间。前房112和后房120包含称为房水的流体,其通过由虹膜114限定的称为瞳孔116的孔在它们之间流动。光通过瞳孔116进入眼睛100并沿着视轴A-A行进,碰触视网膜170,并且因此产生视觉。虹膜114通过控制瞳孔116的大小调节进入眼睛100的光的量。
玻璃体房160位于晶状体130和视网膜170之间并且包含称为玻璃体液的另一流体。玻璃体液比房水粘得多,并且是透明、无色、胶质的物质。虽然玻璃体液的大多数量是水,但是它还包括细胞、盐、糖、玻璃体蛋白(一种胶原)、具有氨基葡聚糖透明质酸的II型胶原纤维的网状物和蛋白质。玻璃体的粘度为纯水粘度的二至四倍,考虑其与胶质一致。它还具有1.336的折射率。
与持续地被补充的眼睛的前房和后房112、120内包含的房水不同,玻璃体液是停滞的。玻璃体常常变得粘性更小,并且作为老化过程的一部分甚至可能瓦解(collapse)。据信,玻璃体液的胶原纤维通过电荷保持分开。随着老化,这些电荷趋于减少,并且可使纤维一起成簇。类似地,玻璃体液可液化——这是称为脱水收缩的情况,这使得细胞和其它有机簇在玻璃体液内自由漂浮。这些使得在视野内被注意到的漂浮物为斑点或纤维绳。
晶状体130是透明的晶体状的蛋白质膜状结构,其是非常有弹性的、通过连接的小带140和睫状肌150保持它在恒定张力下的质量。因此,晶状体130自然地趋向更圆的构造,这是眼睛100近距离处聚焦必须呈现的形状,如图1B中显示。通过改变形状,晶状体起作用以改变眼睛的焦距,以使它能够聚焦在各种距离的物体上,从而使得关注物体的实像形成在视网膜上。
如图1A和1B中显示的,晶状体130可被表征为具有两个表面——在前表面132和在后表面134——的囊。在前表面132面向后房120而在后表面134面向玻璃体160。在后表面134以这种方式接触玻璃体160:在玻璃体160内的流体运动与在后表面134连通并且可引起晶状体130的形状改变。
通过晶状体130形状上的改变和因此它折射光的程度,反映眼睛的自然调节机制。
图1A显示处于相对未调节状态的眼睛100,如可以是眼睛正注视一定距离处时的情况。在未调节状态中,睫状肌150放松,从而增加它的孔的直径并引起小带拉离视轴A-A。这又引起小带140快速拉动晶状体130的周围并引起晶状体130变平。当晶状体130的形状变平时,降低了它弯曲或折射光进入瞳孔的能力。因此,在未调节状态中,晶状体130具有更平的表面,使沿着赤道轴B-B它的直径e1变长并且使其沿着视轴A-A的厚度d1减小(在图1A中比较e2和d2),都相对于调节状态。
图1B显示相对调节状态的眼睛100,如可以是眼睛注视近处物体时的情况。在调节状态中,睫状肌150收缩,并且睫状肌150的收缩引起它们以向前的方向移动。这又降低了小带140上的应力,从而减少了小带140对晶状体130施加的应力。于是,晶状体130经历弹性恢复并且回弹至更放松并且调节的状态,其中晶状体130具有更加凸起的在前表面,使得相对于未调节状态其沿着赤道轴B-B的直径e2减少并且其沿着视轴A-A的厚度d2增加(比较e2和图1A中的d1)。虽然图1B将晶状体囊130的在前表面132和在后表面134描述为具有大致相同的曲率半径,但据信,在调节过程中,在前表面132的曲率半径增加而在后表面134的曲率半径与它的未调节状态没有显著地改变。
如通过图1A和1B显示的,由晶状体130形状上的改变产生调节,包括晶状体囊130(d1对d2)的厚度的改变、晶状体囊130(e1对e2)的直径的改变和晶状体囊130的在前表面132的曲率的改变。尽管睫状肌150已知在施加这些改变上起到重要作用,但据信玻璃体160也起到重要作用,主要是由于晶状体130的在后表面134和玻璃体160之间的接触的性质,其中在后表面134响应并传输玻璃体160内的向前的流体运动,以实现晶状体130形状上的改变。
图2A-C图解了调节性IOL装置200的实施方式,其在去除白内障后可植入眼睛的晶状体囊130内。显示IOL装置200包括光学元件210和连接至光学元件210的柔性膜230。光学元件210和柔性膜230共同限定可充满流体的内腔220。任选地,光学元件210可进一步包括注入孔212以允许流体注入填充腔220。在优选的实施方式中,注入孔212包括单向阀并且是自密封的。在另一优选实施方式中,可提供隔离塞(未显示)以封闭注入孔212。尽管图2-7描绘了注入孔212位于光学元件210内,但应当理解注入孔212的布置不是至关重要的,只要它的布置不会妨碍视觉。
光学元件210可由塑料、聚硅氧烷、丙烯酸类(acrylic)或其组合制造。根据优选的实施方式,光学元件210由为透明热塑塑料聚(甲基丙烯酸甲酯)(PMMA)——其有时称为丙烯酸玻璃(acrylic glass)——制造。因为光学元件210为提供大多数——如果不是基本上全部的——IOC装置的折射能力负责,光学元件210优选地是充分柔性的,以便响应玻璃体在向前的方向上凸出时被施加的向前的力的收缩/放松而改变它的曲率。
根据一个实施方式,弹性地偏置光学元件210使它的形状接近自然和未调节晶状体的形状(参见图1A)。因此,光学元件210响应由玻璃体施加的向前的力而增加它的曲率并且被弹性地偏置为更平的构造或减小的曲率,这类似于在没有向前的力的情况下处于未调节状态的自然晶状体的构造。
根据另一实施方式,弹性地偏置光学元件210使它的形状接近自然和调节的晶状体的形状(参见图1B)。因此,光学元件210被弹性地偏置为类似于处于调节状态的自然晶状体的凸起构造,并且当睫状肌150放松和小带140对晶状体囊130的张力增加时,呈现更小凸起的构造。
在图2A-C中显示的实施方式中,光学元件210具有足够直径的圆盘形状以接合眼睛的小带140。因为该尺寸可根据患者的不同而不同,考虑提供一系列尺寸的光学元件210以适合患者的解剖学。在其它实施方式中,光学元件210可进一步包括分离的触觉系统(图3-6)以接合眼睛的小带140。在这些实施方式中,光学元件210可具有比其中光学元件210直接接合眼睛的小带140的实施方式显著更小的直径。
无论如何,在接合小带140时,IOL装置响应眼睛的部分调节机制,其中睫状肌150和小带140引起光学元件210沿着光轴双向移动,从而提供部分调节响应。
此外,调节性IOL装置200被额外配置来允许光学元件210响应由玻璃体160对其施加的力而改变它的形状。这通过提供柔性光学元件210和流体-填充的柔性膜230完成,所述流体-填充的柔性膜230被配置来在调节期间传输玻璃体160的向前的力以影响晶状体囊130形状上的改变。优选地,为了实现传递晶状体囊130上的玻璃体160的向前移动,膜230接触晶状体囊130的在后表面134的大量区域,并且膜基本上是柔性的并且基本上没有任何妨碍它响应玻璃体160向前移动的刚性材料。因此,调节性IOL装置200在维持晶状体囊130和玻璃体160之间的柔性边界方面不同于现有技术的双晶状体IOL装置。在特别优选的实施方式中,膜230是充分薄且可变形的,以免妨碍晶状体囊130和玻璃体160之间的自然柔性边界。
而且,如以上说明的,白内障外科手术后由晶状体囊130经历的收缩度取决于植入晶状体囊130中的IOL装置的外形和尺寸。因为现有技术装置中的许多具有根本上不同于原始晶状体囊130的外形和/或尺寸(例如,通过沿着光轴A-A具有更小的宽度d或沿着赤道轴B-B具有更小的直径),期望又影响晶状体囊130接合至玻璃体160的程度的收缩度。在一个优选实施方式中,IOL装置通过显著地接合晶状体囊130的轮廓——特别是通过由光学元件210和膜230限定的流体填充的腔220的晶状体囊130的在后表面134——最小化该收缩发生的程度。优选地,在植入时和在已发生晶状体囊130的任何显著收缩之前,膜230被配置来接触大量的——如果不是基本上全部的——晶状体囊130的在后表面134。
如以上参照图1A-B说明的,在调节期间,玻璃体160沿着光轴A-A在向前的方向上施加力,并且在向前的方向上推动晶状体囊130。这又引起晶状体囊130的在前表面132变得更加弯曲,并且因此进一步折射光。
因为光学元件210负责提供大多数——如果不是基本上全部的IOC装置的折射能力,光学元件210优选地是充分柔性的,以便响应玻璃体在向前的方向上凸出时被施加的向前的力的收缩/放松而改变它的曲率。在优选的实施方式中,弹性地偏置光学元件210使它的形状接近自然和未调节晶状体的形状(参见图1A)。因此,光学元件210响应由玻璃体施加的向前的力而增加它的曲率,并且被弹性地偏置为更平的构造或减少的曲率,这类似于在没有向前的力的情况下处于未调节状态的自然晶状体的构造。
柔性膜230可由任何生物相容性弹性材料构造。在优选的实施方式中,柔性膜230具有接近邻近玻璃体的晶状体囊的在后表面的外部表面。柔性膜230优选地被配置和成形以接触晶状体囊的在后表面的大量——如果不是全部——面积。在特别优选的实施方式中,该接触点在在后表面的光轴处和其附近。
优选地,柔性膜230被配置来最大化从玻璃体至晶状体122的这种力的转移。如图1A和1B中显示的,图1A中的未调节眼睛100的晶状体130的在前部分132具有比图1B的调节眼睛100更小的曲率(即,更平)。当玻璃体被认为沿着光轴对晶状体122施加向前的力以实现更大的曲率,优选最大化由在前的玻璃体移动产生的力转移至晶状体122。
根据一个优选实施方式,柔性膜230可具有更大和更小弹性的区域,以便最大化传递玻璃体的向前运动。例如,如图2C中显示的,柔性膜230可包括居中的在后部分224(相应于植入IOL装置200时光轴A-A周围的区域),其具有比邻近圆周部分222更大的弹性。在邻近圆周部分222具有降低的弹性的区域可降低膜230的径向扩展,并允许由玻璃体170施加的向前的力更有效地通过腔220内包含的流体传递并施加至光学元件210,从而增加光学元件210的曲率。
根据另一优选实施方式,IOL装置200可被配置以当它被植入患者的眼睛内时回弹呈现其宽度d3基本上等于调节的眼睛的晶状体囊130的宽度的形状(参见图1B的d2)。这可通过用具有一定程度的形状记忆的弹性材料构建IOL装置200并且还通过用足以扩张柔性膜230至期望宽度d3的一定量流体填充腔220完成。
根据进一步优选的实施方式,IOL装置200包括单个晶状体。在IOL装置中并入其它晶状体很可能妨碍晶状体变形(即,增加它的曲率并且提供其它屈光能力)向前玻璃体移动的能力。
优选地,柔性膜可由聚偏二氟乙烯(PDVF)材料制造。据信,PDVF允许激光能量的传输,而本身不会被降解。任选地,柔性膜230的加固部分234被任选地提供以抵抗在施加各种波长的激光后的降解。在优选实施方式中,当IOL装置200植入对象的眼睛内时在相应于光轴A-A的膜230上的区域处定位加固部分234。通常地,在白内障外科手术后,在晶状体囊中的少数残留的上皮细胞可迁移至囊的在后表面,其导致各种程度的纤维样变性,这又可导致不期望的在后囊的浑浊化(PCO)。PCO是不期望的,特别是在光通路上,并且一般通过施加激光脉冲(例如,YAG激光囊切开术)烧掉纤维化膜进行处理。因此,可在膜230上提供加固部分234作为保护机制以抵抗在膜230上进行激光处理的可能的降解作用。在优选的实施方式中,加固部分234保持柔性并且被制成一定大小以相应于光轴A-A和光轴A-A周围的中心区域。
一旦IOL装置被植入患者的晶状体囊内之后,一定量流体经注入孔212注入腔220内。在优选的实施方式中,流体是盐水或透明质酸的水溶液并且对于IOC装置的折射能力不提供显著或任何的贡献。因此,流体的作用主要作为传输由玻璃体150运动产生的力至光学元件210的媒介物以提供调节。在优选的实施方式中,该流体具有基本上与玻璃体液相同的粘度。在另一优选实施方式中,流体具有基本上与房水或玻璃体液相同的折射率。
IOL装置不同于现有技术的教导,在现有技术的教导中晶状体囊具有各种类型的聚合物——其以液体形式注入并且用UV或其它聚合方法固化。这些尝试已经遇到许多困难,因为它常常难于控制由聚合的聚合物提供的折射能力。此时,基本上——如果不是全部——通过光学元件210提供折射能力,并且腔220内包含的流体不显著地——如果有的话——为提供IOL装置的折射能力做出贡献。而且,与用于填充晶状体囊的现有技术聚合物不同,该流体是相对惰性的或生物相容的材料,如盐水,或可选地,它包含高分子量化合物,如透明质酸,其不会轻易地从IOL装置200泄露。
注入腔220内的流体的精确体积可基于对象的解剖学等而不同。注入腔220内的流体体积不是至关重要的,只要它足以扩张膜230,使得膜230的在后部分基本上接触晶状体囊的在后部分并接合对象的眼睛的玻璃体。如以上说明的,在一个优选实施方式中,一定量流体被注入腔220以便沿着光轴A-A提供IOL装置的宽度d3,其基本上接近调节的眼睛100的晶状体宽度d2。在另一优选实施方式中,一定量流体被注入腔220以便沿着光轴AA提供IOL装置的宽度d3,其基本上接近未调节的眼睛100的宽度d1。
可将IOL装置与触觉系统合并以当植入对象的眼睛内时在光轴A-A处定位光学元件210。因为优选将光学元件210相对于光轴A-A居中,所以触觉系统优选地包括多个放射状地从IOL装置延伸并且在眼睛的晶状体囊130周围接合小带140的触觉元件。
图3A-B描述了包括一对连接至光学元件210的相反面的弹性触觉(spring haptic)350的光学元件210。如图4A-C中进一步显示的,柔性膜230可沿着光学元件210的周围连接至光学元件210/触觉350组件。在柔性膜230和光学元件210的周围之间通过激光焊接和本领域技术人员已知的任何其它方式实现密封。
在另一实施方式中,光学元件210可包含在完全封闭光学元件210的柔性膜230内。根据该元件,柔性膜230具有袋或囊状构造,并且弹性触觉350可连接至(1)光学元件210本身并且从柔性膜230内的密封的孔突出,或连接至(2)柔性膜230。虽然图3-4描述了一对放射状地从光学元件210延伸的弹性触觉350,但是应当理解,可提供任意数量的弹性触觉350,只要当IOL装置被植入眼睛内时光学元件210绕光轴A-A居中。
图5A-B描绘了包括一对连接至光学元件210的相反面的平板触觉(plane haptic)450的光学元件210。平板触觉450包括一对平板元件,每个包括连接至光学元件210的第一末端452和配置以当植入晶状体囊130内时接合眼睛100的小带140的第二末端456。铰合部464置于第一末端452和第二末端456之间,以使当睫状肌150分别放松和收缩时光学元件210在向前和向后方向上横向运动。如图6A-C中进一步显示的,柔性膜230可沿着光学元件210的周围连接至光学元件210/触觉450组件。
在另一实施方式中,光学元件210可包含在完全封闭光学元件210的柔性膜230内。根据该元件,弹性触觉450可连接至(1)光学元件210本身并从柔性膜230内的密封孔突出,或连接至(2)柔性膜230。虽然图5-6描述了一对放射状地从光学元件210延伸的平板触觉450,应当理解,可提供任意数量的平板触觉450,只要当IOL装置植入眼睛内时光学元件210绕光轴A-A居中。
图7描绘了植入调节状态中的眼睛的晶状体囊130内的调节性IOL装置的实施方式。因为光学元件210和IOL装置200的膜230是充分柔性的,所以在植入前可被紧密地被折叠或卷起,从而仅需要几毫米的小切口用于插入眼睛内。如图7中显示的,在将IOL装置植入并且用流体填充腔220之后,IOL装置被粗略分成两部分:面向在后囊120的在前晶状体部分210和面向玻璃体160的在后膜部分230。IOL装置的宽度d3被弹性地偏置,使它的宽度粗略等于处于调节状态中的自然晶状体囊的宽度(参见图1B的d2)。在后膜部分230具有近似晶状体囊130的在后部分134的表面积(参见图1A-B)的接触面积。显示两个或多个触觉550从IOL装置突出,从而基本上使在前晶状体部分210沿着光轴A-A居中。
通过将IOL装置经由对象眼睛的小切口引入对象眼睛的晶状体囊内,将图7中显示的调节性IOL装置植入对象眼睛的晶状体囊内,其中IOL装置包括连接至弹性膜230以限定内腔220的折射光学元件210。然后在对象眼睛的晶状体囊130内定位将IOL装置,从而基本上使折射光学元件210沿着光轴A-A居中。然后,将一定量流体注入IOL装置的内腔220,其足以引起弹性膜230接触晶状体囊的在后部分,晶状体囊的在后部分又至少在光轴A-A和光轴A-A周围的区域内接触玻璃体。在优选的实施方式中,注入内腔220内的流体的体积足以沿着光轴A-A产生IOL装置的宽度d3,其基本上等于调节状态中的自然晶状体囊的宽度。
本文所述和所要求的发明的范围不受本文公开的具体的优选实施方式限制,因为这些实施方式意欲作为本发明的几个方面的阐述。实际上,除了本文显示和描述的那些,本发明的各种改进也由在前的描述对于本领域技术人员来说将变得明显。这种改进也意欲落入所附权利要求的范围内。
Claims (20)
1.适于植入对象眼睛的晶状体囊内的调节性眼内晶状体(IOL)装置,所述IOL装置包括:
在前部分,其包括折射光学元件;
弹性在后部分;和
封闭腔,其被限定在所述在前部分和在后部分之间;
其中所述腔被配置来包含一定量的流体以隔开所述在前部分和在后部分;
其中所述在后部分被配置以当所述IOL装置被植入所述眼睛内并且所述腔包含所述流体时至少在所述光轴和所述光轴周围的区域内接触邻接玻璃体的晶状体囊的在后区域;和
其中所述在后部分响应由所述玻璃体施加的向前的力动作,引起所述流体对所述折射光学元件施加变形或位移力。
2.权利要求1所述的调节性IOL装置,其中所述折射光学元件响应所述向前的力而增加它的曲率,并且在没有所述向前的力的情况下减小它的曲率。
3.权利要求2所述的调节性IOL装置,其中弹性地偏置所述折射光学元件,使它的曲率基本上等于所述对象的自然晶状体囊的在前部分的曲率。
4.权利要求1所述的调节性IOL装置,其中偏置所述IOL装置,使它的构造的宽度基本上等于沿着所述光轴的未调节的自然晶状体囊的宽度。
5.权利要求1所述的调节性IOL装置,其中所述IOL装置的赤道部直径基本上等于未调节状态中的所述对象的自然晶状体囊的赤道部直径。
6.权利要求1所述的调节性IOL装置,其中将所述在前部分制成一定大小以当将所述IOL装置植入所述对象的眼睛内时接合小带。
7.权利要求1所述的调节性IOL装置,进一步包括连接至所述在前部分的触觉系统。
8.权利要求7所述的调节性IOL装置,其中所述触觉系统被配置以当植入所述对象的眼睛内时基本上使所述折射光学元件在所述光轴的路径上居中。
9.权利要求8所述的调节性IOL装置,其中所述触觉系统被配置以当所述IOL装置植入所述对象的眼睛内时响应睫状肌的收缩和放松沿着所述光轴双向位移所述折射光学元件。
10.权利要求1所述的调节性IOL装置,其中包含在所述腔内的所述流体的体积足以沿着所述光轴以距离d3隔开所述在前部分和在后部分,距离d3基本上等于处于未调节状态中的沿着所述光轴的所述对象的自然晶状体囊的宽度d2。
11.适于植入对象眼睛的晶状体囊内的调节性眼内晶状体(IOL)装置,所述IOL装置包括:
在前折射光学元件;和
包括在后表面的膜,所述膜连接至所述在前光学元件并且限定配置以包含一定量流体的封闭腔;
其中所述在后部分被配置以当所述IOL装置植入所述眼睛内并且所述腔包含所述流体时至少在所述光轴和所述光轴周围的区域内接触邻接玻璃体的晶状体囊的在后区域;和
其中所述流体响应由所述玻璃体对所述在后表面施加的向前的力使所述在前折射光学元件变形。
12.权利要求11所述的调节性IOL装置,其中所述在前光学元件进一步包括自封阀,以允许所述流体注入。
13.权利要求11所述的调节性IOL装置,其中所述流体是粘弹性的。
14.权利要求11所述的调节性IOL装置,其中所述流体是盐水或透明质酸的水溶液。
15.权利要求11所述的调节性IOL装置,其中所述流体具有与所述玻璃体液基本上相同的粘度。
16.权利要求11所述的调节性IOL装置,其中所述流体具有与所述房水或所述玻璃体液基本上相同的折射率。
17.权利要求11所述的调节性IOL装置,其中所述膜围绕所述在前折射光学元件的周围连接至所述在前折射光学元件。
18.权利要求11所述的调节性IOL装置,其中所述在前折射光学元件包含在所述膜的封闭腔内。
19.权利要求11所述的调节性IOL装置,其中所述在后部分进一步包括加固部分。
20.用于在对象的眼睛内植入调节性眼内调节性晶状体(IOL)装置的方法,其包括:
通过所述对象眼睛内的切口将IOL装置引入所述对象眼睛的晶状体囊内,其中所述IOL装置包括连接至弹性膜以限定内腔的折射光学元件;
定位在所述对象眼睛的晶状体囊内的所述IOL装置,以使所述折射光学元件基本上沿着光轴居中;和
将一定量流体注入所述IOL装置的内腔,其足以引起所述弹性膜至少在所述光轴和所述光轴周围的区域内接触邻接玻璃体的晶状体囊的在后区域。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34338610P | 2010-04-27 | 2010-04-27 | |
US61/343,386 | 2010-04-27 | ||
PCT/US2011/034197 WO2011137191A1 (en) | 2010-04-27 | 2011-04-27 | Accommodating intraocular lens device |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102883682A true CN102883682A (zh) | 2013-01-16 |
Family
ID=44861904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180021257XA Pending CN102883682A (zh) | 2010-04-27 | 2011-04-27 | 调节眼内晶状体的装置 |
Country Status (5)
Country | Link |
---|---|
US (2) | US20130053954A1 (zh) |
EP (1) | EP2563275A4 (zh) |
JP (1) | JP2013525028A (zh) |
CN (1) | CN102883682A (zh) |
WO (1) | WO2011137191A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106535823A (zh) * | 2014-07-31 | 2017-03-22 | 雷恩斯根公司 | 调节眼内晶状体装置 |
CN107708615A (zh) * | 2015-05-01 | 2018-02-16 | 麦迪凯姆眼科(塞浦路斯)有限公司 | 用于经由眼睛球面像差的定制化而优化视觉的方法和装置 |
CN107847316A (zh) * | 2015-05-28 | 2018-03-27 | 阿维·哈达德 | 眼内晶状体以及用于调节现有的自适应眼内晶状体的方法 |
CN108272534A (zh) * | 2018-01-23 | 2018-07-13 | 上海理工大学 | 一种可连续变焦的人工晶状体 |
CN109789012A (zh) * | 2016-05-27 | 2019-05-21 | 雷恩斯根公司 | 用于眼内晶状体装置的具有窄分子量分布的晶状体油 |
CN110279494A (zh) * | 2014-08-26 | 2019-09-27 | 施菲姆德控股有限责任公司 | 调节性人工晶状体 |
CN110996850A (zh) * | 2017-06-07 | 2020-04-10 | 施菲姆德控股有限责任公司 | 可调节光学度数的眼内透镜 |
CN115245404A (zh) * | 2021-04-27 | 2022-10-28 | 卡尔蔡司医疗技术股份公司 | 用于生产可调节人工晶状体的方法 |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10835373B2 (en) | 2002-12-12 | 2020-11-17 | Alcon Inc. | Accommodating intraocular lenses and methods of use |
US9610155B2 (en) | 2008-07-23 | 2017-04-04 | Powervision, Inc. | Intraocular lens loading systems and methods of use |
US8668734B2 (en) | 2010-07-09 | 2014-03-11 | Powervision, Inc. | Intraocular lens delivery devices and methods of use |
US8968396B2 (en) | 2007-07-23 | 2015-03-03 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
US9943402B2 (en) | 2008-11-20 | 2018-04-17 | Insight Innovations, Llc | Micropatterned intraocular implant |
ES2606491T3 (es) | 2008-11-20 | 2017-03-24 | Insight Innovations, Llc | Sistema de implante intraocular biodegradable y biocompatible |
US20120232649A1 (en) | 2008-11-20 | 2012-09-13 | Insight Innovations, Llc | Intraocular Lens Cell Migration Inhibition System |
US10299913B2 (en) | 2009-01-09 | 2019-05-28 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
JP2013520291A (ja) | 2010-02-23 | 2013-06-06 | パワーヴィジョン・インコーポレーテッド | 遠近調節型眼内レンズのための液体 |
WO2011137191A1 (en) | 2010-04-27 | 2011-11-03 | Ramgopal Rao | Accommodating intraocular lens device |
US9220590B2 (en) | 2010-06-10 | 2015-12-29 | Z Lens, Llc | Accommodative intraocular lens and method of improving accommodation |
US8771347B2 (en) | 2011-05-23 | 2014-07-08 | California Institute Of Technology | Accommodating intraocular lens |
US8715345B2 (en) * | 2011-05-23 | 2014-05-06 | California Institute Of Technology | Accommodating intraocular lens |
US10433949B2 (en) | 2011-11-08 | 2019-10-08 | Powervision, Inc. | Accommodating intraocular lenses |
WO2013112589A1 (en) | 2012-01-24 | 2013-08-01 | Regents Of The University Of Colorado | Modular intraocular lens designs and methods |
US9364318B2 (en) | 2012-05-10 | 2016-06-14 | Z Lens, Llc | Accommodative-disaccommodative intraocular lens |
US9186244B2 (en) | 2012-12-21 | 2015-11-17 | Lensgen, Inc. | Accommodating intraocular lens |
US9486311B2 (en) | 2013-02-14 | 2016-11-08 | Shifamed Holdings, Llc | Hydrophilic AIOL with bonding |
JP6717740B2 (ja) | 2013-03-15 | 2020-07-01 | パワーヴィジョン・インコーポレーテッド | 眼内レンズの収容および載置装置ならびにその使用方法 |
US10195018B2 (en) | 2013-03-21 | 2019-02-05 | Shifamed Holdings, Llc | Accommodating intraocular lens |
CN107961101B (zh) | 2013-03-21 | 2019-12-27 | 施菲姆德控股有限责任公司 | 调节性人工晶状体 |
US9310628B2 (en) * | 2013-08-27 | 2016-04-12 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lens including ultra-thin optical parts |
JP6033753B2 (ja) * | 2013-10-21 | 2016-11-30 | 株式会社クラレ | 層間接着性に優れる積層体 |
CN109806027A (zh) | 2013-11-01 | 2019-05-28 | 雷恩斯根公司 | 双部件调节性人工晶状体设备 |
WO2015066502A1 (en) | 2013-11-01 | 2015-05-07 | Thomas Silvestrini | Accomodating intraocular lens device |
JP2017505702A (ja) | 2014-02-18 | 2017-02-23 | クラービスタ メディカル, インコーポレイテッドClarvista Medical, Inc. | モジュール式眼内レンズの設計、器具および方法 |
JP6754755B2 (ja) | 2014-09-23 | 2020-09-16 | レンスゲン、インコーポレイテッド | 調節性眼内レンズ用の高分子材料 |
US20160089232A1 (en) * | 2014-09-29 | 2016-03-31 | Charles DeBoer | Systems, intraocular lenses, and methods for treatment of posterior capsule opacification |
EP3240590A1 (en) * | 2014-12-29 | 2017-11-08 | Ico, Inc. | Flexible valve structure for implantable reservoir |
CA2974639A1 (en) | 2015-01-30 | 2016-08-04 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
CN113730030A (zh) | 2015-11-04 | 2021-12-03 | 克拉维斯塔医疗有限公司 | 模块化人工晶状体设计、工具和方法 |
CN108348328B (zh) | 2015-11-06 | 2020-04-10 | 力景公司 | 可调节人工晶状体和制造方法 |
US11141263B2 (en) | 2015-11-18 | 2021-10-12 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lens |
CN113180886A (zh) | 2015-12-01 | 2021-07-30 | 雷恩斯根公司 | 调节性人工晶状体装置 |
US11045309B2 (en) | 2016-05-05 | 2021-06-29 | The Regents Of The University Of Colorado | Intraocular lens designs for improved stability |
US10512535B2 (en) | 2016-08-24 | 2019-12-24 | Z Lens, Llc | Dual mode accommodative-disaccomodative intraocular lens |
US10350056B2 (en) | 2016-12-23 | 2019-07-16 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lenses and methods for making and using same |
US11197752B2 (en) | 2017-05-05 | 2021-12-14 | Verily Life Sciences Llc | Situ filling and sealing of electrowetting intraocular lenses |
CN110996848B (zh) | 2017-05-30 | 2023-08-04 | 施菲姆德控股有限责任公司 | 调节性人工晶状体的表面处理以及相关方法和装置 |
EP3415117A1 (en) * | 2017-06-15 | 2018-12-19 | Laser Vista AG | Intraocular lens implant |
US10898316B2 (en) | 2018-03-01 | 2021-01-26 | Jellisee Ophthalmics Inc | Intraocular lens |
MX2021011739A (es) | 2019-03-25 | 2022-01-06 | Akkolens Int B V | Combinación de lentes intraoculares para la restauración de la refracción y la acomodación. |
WO2020226711A1 (en) | 2019-05-03 | 2020-11-12 | JelliSee Ophthalmics Inc. | Intraocular lenses with shape-changing optics |
US20220218466A1 (en) | 2019-05-15 | 2022-07-14 | Akkolens International B.V. | Accommodating Intraocular Lenses with Combination of Mechanical Driving Components |
WO2021034187A1 (en) | 2019-08-19 | 2021-02-25 | Akkolens International B.V. | Accommodative intraocular lens combination with independent fixed and variable power lens sections |
KR20220098761A (ko) * | 2019-11-07 | 2022-07-12 | 렌즈젠, 인크. | 안구내 렌즈 장치용 실리콘 오일 삼중합체 |
NL2027301B1 (en) | 2020-01-13 | 2021-10-26 | Akkolens Int B V | Mechanical means for accommodative intraocular lens |
NL2028038B1 (en) | 2020-05-11 | 2022-07-04 | Akkolens Int B V | Method to connect and distance hydrophilic intraocular lens elements |
US11357620B1 (en) | 2021-09-10 | 2022-06-14 | California LASIK & Eye, Inc. | Exchangeable optics and therapeutics |
KR20230172951A (ko) * | 2022-06-16 | 2023-12-26 | 가톨릭대학교 산학협력단 | 전안부 안정화장치 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4932966A (en) * | 1988-08-15 | 1990-06-12 | Storz Instrument Company | Accommodating intraocular lens |
US5275623A (en) * | 1991-11-18 | 1994-01-04 | Faezeh Sarfarazi | Elliptical accommodative intraocular lens for small incision surgery |
CN1379644A (zh) * | 1999-09-10 | 2002-11-13 | 兰多·伍兹 | 具有调节能力的植入式眼内人工晶状体 |
US20070021831A1 (en) * | 2005-07-19 | 2007-01-25 | Clarke Gerald P | Accommodating intraocular lens and methods of use |
CN101277659A (zh) * | 2005-09-28 | 2008-10-01 | 兴和株式会社 | 眼内透镜 |
US20090319040A1 (en) * | 2006-09-16 | 2009-12-24 | Elie Khoury | Accommodative intra-ocular lens |
Family Cites Families (310)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032502A (en) | 1975-10-10 | 1977-06-28 | Dow Corning Corporation | Organosiloxane compositions for liquid injection |
US4373218A (en) | 1980-11-17 | 1983-02-15 | Schachar Ronald A | Variable power intraocular lens and method of implanting into the posterior chamber |
US4512040A (en) | 1982-06-09 | 1985-04-23 | Mcclure Hubert L | Bifocal intraocular lens |
US4720286A (en) | 1984-07-20 | 1988-01-19 | Bailey Kelvin E | Multifocus intraocular lens |
US4585457A (en) | 1985-05-16 | 1986-04-29 | Kalb Irvin M | Inflatable intraocular lens |
US4676791A (en) | 1985-08-01 | 1987-06-30 | Surgidev Corporation | Intraocular lens and method for making same |
US4731078A (en) | 1985-08-21 | 1988-03-15 | Kingston Technologies Limited Partnership | Intraocular lens |
US5059668A (en) | 1986-01-20 | 1991-10-22 | Shin-Etsu Chemical Co., Ltd. | Fluorosilicone rubber composition |
US5236970A (en) | 1987-02-05 | 1993-08-17 | Allergan, Inc. | Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses |
US4842601A (en) | 1987-05-18 | 1989-06-27 | Smith S Gregory | Accommodating intraocular lens and method of implanting and using same |
US5074876A (en) | 1987-12-04 | 1991-12-24 | Kelman Charles D | Two piece intraocular lens |
US4888012A (en) | 1988-01-14 | 1989-12-19 | Gerald Horn | Intraocular lens assemblies |
EP0328117B1 (en) | 1988-02-12 | 1994-12-28 | Menicon Co., Ltd. | Processes for production of a Baloon for an intraocular lens |
US4822360A (en) | 1988-03-16 | 1989-04-18 | University Of Utah | Inflatable, intraocular lens and method of implanting the lens in the capsule of an eye |
US4882368A (en) | 1988-09-26 | 1989-11-21 | Dow Corning Corporation | Low compression set fluorosilicone rubber |
US4892543A (en) * | 1989-02-02 | 1990-01-09 | Turley Dana F | Intraocular lens providing accomodation |
US5227447A (en) | 1989-12-07 | 1993-07-13 | Shin-Etsu Chemical Co., Ltd. | Preparation of high molecular weight organopolysiloxane |
US5152788A (en) | 1989-12-27 | 1992-10-06 | Minnesota Mining And Manufacturing Company | Multifocal diffractive ophthalmic lens and method of manufacture |
JPH03202102A (ja) | 1989-12-28 | 1991-09-03 | Toray Dow Corning Silicone Co Ltd | オルガノポリシロキサン成形物中のシロキサンオリゴマー量の減少方法 |
US6197059B1 (en) | 1990-04-27 | 2001-03-06 | Medevec Licensing, B.V. | Accomodating intraocular lens |
US5217491A (en) | 1990-12-27 | 1993-06-08 | American Cyanamid Company | Composite intraocular lens |
WO1992017132A1 (de) | 1991-03-25 | 1992-10-15 | Albert Daxer | Kunstlinse |
FR2681524B1 (fr) | 1991-09-25 | 1997-04-04 | Mnao | Implant cristallinien. |
US5171773A (en) | 1991-11-13 | 1992-12-15 | Dow Corning Corporation | High strength fluorosilicone rubber |
US5278258A (en) | 1992-05-18 | 1994-01-11 | Allergan, Inc. | Cross-linked silicone polymers, fast curing silicone precursor compositions, and injectable intraocular lenses |
US5312860A (en) | 1992-09-10 | 1994-05-17 | Shin-Etsu Chemical Co., Ltd. | Heat-curable silicone rubber composition and cured product thereof |
US5264522A (en) | 1992-09-10 | 1993-11-23 | Shin-Etsu Chemical Co., Ltd. | Heat-curable fluorosilicone rubber composition and cured product thereof |
US5443506A (en) | 1992-11-18 | 1995-08-22 | Garabet; Antoine L. | Lens with variable optical properties |
US5336487A (en) | 1993-03-05 | 1994-08-09 | Refojo Miguel F | Method of treating eye disorders with silicon/fluorosilicone copolymer oil |
US5447987A (en) | 1993-12-24 | 1995-09-05 | Shin-Etsu Chemical Co., Ltd. | Organopolysiloxane compositions |
EP0741637B1 (en) | 1994-01-31 | 1999-07-28 | Bausch & Lomb Incorporated | Treatment of contact lenses with supercritical fluid |
US5489302A (en) * | 1994-05-24 | 1996-02-06 | Skottun; Bernt C. | Accommodating intraocular lens |
WO1996000745A2 (en) | 1994-06-30 | 1996-01-11 | Minnesota Mining And Manufacturing Company | Cure-indicating molding and coating composition |
US5607472A (en) | 1995-05-09 | 1997-03-04 | Emory University | Intraocular lens for restoring accommodation and allows adjustment of optical power |
US5774274A (en) | 1995-05-12 | 1998-06-30 | Schachar; Ronald A. | Variable focus lens by small changes of the equatorial lens diameter |
JPH09150002A (ja) | 1995-11-29 | 1997-06-10 | Shin Etsu Chem Co Ltd | シリコーンオイルの精製方法 |
US5665794A (en) | 1996-05-20 | 1997-09-09 | Dow Corning Corporation | Method for controlling cure initiation and curing times of platinum group metal curing fluorosilicone compositions |
DE19654488A1 (de) | 1996-12-27 | 1998-07-02 | Sueddeutsche Kalkstickstoff | Verfahren zur Fraktionierung viscoser Silicone |
US5854310A (en) | 1997-07-21 | 1998-12-29 | Dow Corning Corporation | Curable fluorosilicone composition having improved lubricity |
US6361561B1 (en) | 1998-10-13 | 2002-03-26 | Pharmacia & Upjohn Ab | Injectable intraocular lens |
US6197057B1 (en) | 1998-10-27 | 2001-03-06 | Gholam A. Peyman | Lens conversion system for teledioptic or difractive configurations |
US6117171A (en) | 1998-12-23 | 2000-09-12 | Skottun; Bernt Christian | Encapsulated accommodating intraocular lens |
US7662179B2 (en) | 1999-04-09 | 2010-02-16 | Sarfarazi Faezeh M | Haptics for accommodative intraocular lens system |
US20030060881A1 (en) | 1999-04-30 | 2003-03-27 | Advanced Medical Optics, Inc. | Intraocular lens combinations |
US20060238702A1 (en) | 1999-04-30 | 2006-10-26 | Advanced Medical Optics, Inc. | Ophthalmic lens combinations |
US6767363B1 (en) | 1999-11-05 | 2004-07-27 | Bausch & Lomb Surgical, Inc. | Accommodating positive and negative intraocular lens system |
US6551354B1 (en) | 2000-03-09 | 2003-04-22 | Advanced Medical Optics, Inc. | Accommodating intraocular lens |
US6613343B2 (en) | 2000-04-12 | 2003-09-02 | Pharmacia Groningen Bv | Injectable intraocular accommodating lens |
US20050251254A1 (en) | 2000-06-02 | 2005-11-10 | Brady Daniel G | Method of implanting accommodating intraocular lenses |
US6730123B1 (en) | 2000-06-22 | 2004-05-04 | Proteus Vision, Llc | Adjustable intraocular lens |
WO2002005015A2 (en) | 2000-07-11 | 2002-01-17 | The Johns Hopkins University School Of Medicine | Device for inserting an injectable bag intraocular lens within a human eye |
US20030078657A1 (en) | 2001-01-25 | 2003-04-24 | Gholam-Reza Zadno-Azizi | Materials for use in accommodating intraocular lens system |
US6764511B2 (en) | 2001-01-25 | 2004-07-20 | Visiogen, Inc. | Distending portion for intraocular lens system |
US7780729B2 (en) | 2004-04-16 | 2010-08-24 | Visiogen, Inc. | Intraocular lens |
US8062361B2 (en) | 2001-01-25 | 2011-11-22 | Visiogen, Inc. | Accommodating intraocular lens system with aberration-enhanced performance |
US20040148023A1 (en) | 2001-02-15 | 2004-07-29 | Shu Stephen K. | High gain wide range accommodating intraocular lens for implant into the capsular bag |
US20020120329A1 (en) | 2001-02-28 | 2002-08-29 | Allergan Sales, Inc. | Moveable intraocular lenses and combinations of intraocular lenses |
US6855164B2 (en) | 2001-06-11 | 2005-02-15 | Vision Solutions Technologies, Llc | Multi-focal intraocular lens, and methods for making and using same |
US7229475B2 (en) | 2001-06-11 | 2007-06-12 | Vision Solutions Technologies, Inc. | Multi-focal intraocular lens, and methods for making and using same |
US20030105522A1 (en) | 2001-06-11 | 2003-06-05 | Glazier Alan N. | Multi-focal intraocular lens |
IL145015A0 (en) | 2001-08-21 | 2002-06-30 | Nun Yehoshua Ben | Accommodating lens |
US20030060878A1 (en) | 2001-08-31 | 2003-03-27 | Shadduck John H. | Intraocular lens system and method for power adjustment |
US7097660B2 (en) | 2001-12-10 | 2006-08-29 | Valdemar Portney | Accommodating intraocular lens |
JP3985133B2 (ja) | 2001-12-21 | 2007-10-03 | 信越化学工業株式会社 | チキソ性含フッ素硬化性組成物及びこれを用いた封止物 |
US7122053B2 (en) | 2002-12-12 | 2006-10-17 | Powervision, Inc. | Accommodating intraocular lens system and method |
US7261737B2 (en) | 2002-12-12 | 2007-08-28 | Powervision, Inc. | Accommodating intraocular lens system and method |
US8048155B2 (en) | 2002-02-02 | 2011-11-01 | Powervision, Inc. | Intraocular implant devices |
US20070100445A1 (en) | 2003-02-03 | 2007-05-03 | Shadduck John H | Intraocular lenses and business methods |
US20050021139A1 (en) | 2003-02-03 | 2005-01-27 | Shadduck John H. | Ophthalmic devices, methods of use and methods of fabrication |
US6860601B2 (en) * | 2002-02-06 | 2005-03-01 | John H. Shadduck | Adaptive optic lens system and method of use |
US20030181749A1 (en) | 2002-03-21 | 2003-09-25 | Kunzler Jay F. | Supercritical fluid extraction of vitreoretinal silicone tamponades |
US6695881B2 (en) | 2002-04-29 | 2004-02-24 | Alcon, Inc. | Accommodative intraocular lens |
CA2849167C (en) * | 2002-07-25 | 2016-06-28 | Visiogen, Inc. | Intraocular lenses and methods of preparing or making same |
AU2003281766A1 (en) | 2002-07-29 | 2004-02-16 | Yosef Gross | Tensioning intraocular lens assembly |
AU2002950469A0 (en) | 2002-07-30 | 2002-09-12 | Commonwealth Scientific And Industrial Research Organisation | Improved biomedical compositions |
US6966649B2 (en) | 2002-08-12 | 2005-11-22 | John H Shadduck | Adaptive optic lens system and method of use |
FR2844703B1 (fr) | 2002-09-25 | 2005-07-08 | Alain Nicolas Gilg | Dispositif intraoculaire pour restaurer l'accommodation de l'oeil atteint de presbytie |
US20040082993A1 (en) | 2002-10-25 | 2004-04-29 | Randall Woods | Capsular intraocular lens implant having a refractive liquid therein |
US7125422B2 (en) | 2002-10-25 | 2006-10-24 | Quest Vision Technology, Inc. | Accommodating intraocular lens implant |
JP4473217B2 (ja) | 2002-10-25 | 2010-06-02 | クエスト ヴィジョン テクノロジー, アイエヌシー. | 埋め込み可能な人工水晶体 |
WO2004046768A2 (en) | 2002-11-20 | 2004-06-03 | Powervision | Lens system and method for power adjustment |
US20040111152A1 (en) | 2002-12-10 | 2004-06-10 | Kelman Charles David | Accommodating multifocal intraocular lens |
US8361145B2 (en) | 2002-12-12 | 2013-01-29 | Powervision, Inc. | Accommodating intraocular lens system having circumferential haptic support and method |
AU2003297101A1 (en) | 2002-12-12 | 2004-06-30 | Powervision | Lens system for power adjustment using micropumps |
US7247168B2 (en) | 2002-12-12 | 2007-07-24 | Powervision, Inc. | Accommodating intraocular lens system and method |
US7637947B2 (en) | 2002-12-12 | 2009-12-29 | Powervision, Inc. | Accommodating intraocular lens system having spherical aberration compensation and method |
US7217288B2 (en) | 2002-12-12 | 2007-05-15 | Powervision, Inc. | Accommodating intraocular lens having peripherally actuated deflectable surface and method |
US10835373B2 (en) | 2002-12-12 | 2020-11-17 | Alcon Inc. | Accommodating intraocular lenses and methods of use |
US8328869B2 (en) | 2002-12-12 | 2012-12-11 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
US6616691B1 (en) | 2003-01-10 | 2003-09-09 | Alcon, Inc. | Accommodative intraocular lens |
US7238201B2 (en) | 2003-02-13 | 2007-07-03 | Visiogen, Inc. | Accommodating intraocular lens system with enhanced range of motion |
EP1599748A4 (en) | 2003-03-06 | 2007-10-24 | John H Shadduck | ADAPTIVE OPTICAL LENS AND METHOD OF MANUFACTURE |
US7223288B2 (en) | 2003-05-21 | 2007-05-29 | Alcon, Inc. | Accommodative intraocular lens |
US20040249455A1 (en) | 2003-06-09 | 2004-12-09 | Tran Son Trung | Accommodative intraocular lens system |
GB0319408D0 (en) | 2003-08-19 | 2003-09-17 | Chawdhary Satish | Intraocular device |
DE10346024B4 (de) | 2003-08-26 | 2019-01-17 | Carl Zeiss Meditec Ag | Ciliarmuskel-betätigtes, akkommodationsfähiges Linsenimplantat |
DE20316792U1 (de) | 2003-08-26 | 2005-01-05 | Schedler, Markus | Ciliarmuskel-betätigtes, akkommodationsfähiges Linsenimplantat |
WO2005048882A1 (en) | 2003-11-18 | 2005-06-02 | Medennium, Inc. | Accommodative intraocular lens and method of implantation |
US20050137703A1 (en) | 2003-12-05 | 2005-06-23 | Vanderbilt University | Accommodative intraocular lens |
US20050131535A1 (en) | 2003-12-15 | 2005-06-16 | Randall Woods | Intraocular lens implant having posterior bendable optic |
NL1025622C2 (nl) | 2004-03-03 | 2005-09-07 | Accolens Internat B V | Twee tezamen een lens vormende optische elementen met variabele optische sterkte voor gebruik als intra-oculaire lens. |
US7150760B2 (en) | 2004-03-22 | 2006-12-19 | Alcon, Inc. | Accommodative intraocular lens system |
US20110118834A1 (en) | 2004-03-31 | 2011-05-19 | Yuhwa Lo | Fluidic intraocular lens systems and methods |
US8018658B2 (en) | 2004-03-31 | 2011-09-13 | The Regents Of The Univeristy Of California | Fluidic adaptive lens systems and methods |
AU2005267561A1 (en) | 2004-03-31 | 2006-02-02 | The Regents Of The University Of California | Fluidic adaptive lens |
US7453646B2 (en) | 2004-03-31 | 2008-11-18 | The Regents Of The University Of California | Fluidic adaptive lens systems and methods |
IL161706A0 (en) | 2004-04-29 | 2004-09-27 | Nulens Ltd | Intraocular lens fixation device |
US9005282B2 (en) | 2004-04-30 | 2015-04-14 | Calhoun Vision, Inc. | Intraocular lens system with injectable accommodation material |
US9713527B2 (en) | 2004-04-30 | 2017-07-25 | Rxsight, Inc. | Multilens intraocular lens system with injectable accommodation material |
US7063723B2 (en) | 2004-07-23 | 2006-06-20 | Sun Ran | Intraocular lens with an accommodating capability |
US20100057095A1 (en) * | 2004-08-18 | 2010-03-04 | Leonid Orbachevsky | Method of Refraction Surgery of the Eye and a Tool for Implanting Intraocular Refractive Lens |
US7806929B2 (en) | 2004-08-27 | 2010-10-05 | Brown David C | Intracapsular pseudophakic device |
US20060069178A1 (en) | 2004-09-24 | 2006-03-30 | Bausch & Lomb Incorporated | Method for polymerizing ophthalmic devices |
WO2006040759A1 (en) | 2004-10-13 | 2006-04-20 | Nulens Ltd | Accommodating intraocular lens (aiol), and aiol assemblies including same |
US9872763B2 (en) | 2004-10-22 | 2018-01-23 | Powervision, Inc. | Accommodating intraocular lenses |
SE0403091D0 (sv) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New composition for injectable ophtalmic lenses |
SE0403093D0 (sv) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New polysiloxanes; synthesis and use thereof |
US20120071972A1 (en) | 2004-12-29 | 2012-03-22 | Iris Ginron Zhao | Multiphase eyecare |
US8216306B2 (en) | 2005-01-13 | 2012-07-10 | Minas Theodore Coroneo | Ocular auto-focusing lenses |
NL1029041C1 (nl) | 2005-03-09 | 2006-09-12 | Akkolens Int Bv | Verbeterde constructie van een intra-oculaire kunstlens. |
CN101203192B (zh) | 2005-03-30 | 2010-09-15 | 纽镜有限公司 | 可调节人工晶状体组件及其分离元件 |
US20060241752A1 (en) | 2005-04-20 | 2006-10-26 | Israel Henry M | Accommodating multiple lens assembly |
JP4476162B2 (ja) * | 2005-04-28 | 2010-06-09 | 株式会社ニデック | 眼内レンズ |
EP1890652B1 (en) | 2005-05-13 | 2017-08-02 | Akkolens International B.V. | Intra-ocular artificial lens for iris-driven accommodation |
GB0510196D0 (en) | 2005-05-19 | 2005-06-22 | Univ Liverpool | Composition for treatment of a detached retina and method of production thereof |
EP1726272B1 (de) | 2005-05-27 | 2009-07-08 | Wavelight Laser Technologie AG | Intraokularlinse |
GB2427484A (en) | 2005-06-21 | 2006-12-27 | Global Bionic Optics Pty Ltd | Variable power fluid lens with flexible wall |
US7591849B2 (en) | 2005-07-01 | 2009-09-22 | Bausch & Lomb Incorpoted | Multi-component accommodative intraocular lens with compressible haptic |
US20070016293A1 (en) | 2005-07-18 | 2007-01-18 | Alcon, Inc. | Accommodative intraocular lens system |
US20070032868A1 (en) | 2005-08-08 | 2007-02-08 | Randall Woods | Capsular shape-restoring device |
US7316713B2 (en) | 2005-08-29 | 2008-01-08 | Alcon, Inc. | Accommodative intraocular lens system |
US9629712B2 (en) | 2005-09-01 | 2017-04-25 | Donald C. Stenger | Accommodating intraocular lens |
US8034107B2 (en) | 2005-09-01 | 2011-10-11 | Stenger Donald C | Accommodating intraocular lens |
US9636213B2 (en) | 2005-09-30 | 2017-05-02 | Abbott Medical Optics Inc. | Deformable intraocular lenses and lens systems |
US20070088433A1 (en) | 2005-10-17 | 2007-04-19 | Powervision | Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use |
US8603164B2 (en) | 2005-10-27 | 2013-12-10 | Gholam A. Peyman | Adjustable fluidic telescope |
US20070118216A1 (en) | 2005-11-21 | 2007-05-24 | Joel Pynson | Accommodative intraocular lens |
US7981155B2 (en) * | 2005-12-07 | 2011-07-19 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
US20070129800A1 (en) | 2005-12-07 | 2007-06-07 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
US7985253B2 (en) * | 2005-12-07 | 2011-07-26 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
JP5068765B2 (ja) | 2005-12-14 | 2012-11-07 | ノバルティス アーゲー | シリコーンヒドロゲルの製造方法 |
US20070260308A1 (en) | 2006-05-02 | 2007-11-08 | Alcon, Inc. | Accommodative intraocular lens system |
WO2007134019A2 (en) | 2006-05-08 | 2007-11-22 | Bausch & Lomb Incorporated | Accommodative intraocular lens having defined axial compression characteristics |
US20100004742A1 (en) | 2006-08-15 | 2010-01-07 | C7C Vision International Limited | Multiocular Intraocular Lens System |
US20080046077A1 (en) | 2006-08-15 | 2008-02-21 | C&C Vision International Limited | Multiocular Intraocular Lens Systems |
US20080051886A1 (en) | 2006-08-24 | 2008-02-28 | Lin J T | Method and device for vision correction via dual-optics accommodating intraocular lens |
EP1932492B1 (en) | 2006-12-13 | 2011-09-14 | Akkolens International B.V. | Accommodating intraocular lens with variable correction |
WO2008079671A1 (en) | 2006-12-22 | 2008-07-03 | Bausch & Lomb Incorporated | Multi-element accommodative intraocular lens |
AU2007338100B2 (en) | 2006-12-22 | 2014-01-30 | Amo Groningen Bv | Accommodating intraocular lens, lens system and frame therefor |
JP5207626B2 (ja) | 2006-12-26 | 2013-06-12 | 東レ・ダウコーニング株式会社 | シリコーンゴム層と異種ゴム層からなるゴム積層体用加熱硬化性シリコーンゴム組成物、ゴム積層体およびその製造方法 |
US7713299B2 (en) | 2006-12-29 | 2010-05-11 | Abbott Medical Optics Inc. | Haptic for accommodating intraocular lens |
CA2674018C (en) | 2006-12-29 | 2015-05-26 | Advanced Medical Optics, Inc. | Multifocal accommodating intraocular lens |
US8608799B2 (en) | 2007-01-24 | 2013-12-17 | Tekia, Inc. | Umbrella-shaped accommodating artificial ocular lens (AAOL) device |
EP2111188A4 (en) | 2007-02-02 | 2010-01-13 | Key Medical Technologies Inc | INTERFACE refraction ADJUSTMENT LENS |
US8034106B2 (en) * | 2007-02-02 | 2011-10-11 | Adoptics Ag | Interfacial refraction accommodating lens (IRAL) |
JP5452235B2 (ja) | 2007-02-21 | 2014-03-26 | パワーヴィジョン・インコーポレーテッド | 眼科用デバイスに適したポリマー材料及びその製造方法 |
US20080306587A1 (en) | 2007-02-21 | 2008-12-11 | Jingjong Your | Lens Material and Methods of Curing with UV Light |
US7986465B1 (en) | 2007-03-01 | 2011-07-26 | Rhevision Technology, Inc. | Systems and methods for effecting zoom and focus using fluidic adaptive lenses |
ATE483427T1 (de) | 2007-03-05 | 2010-10-15 | Nulens Ltd | Einheitlich akkommodierende intraokularlinsen (aiols) und diskrete basiselemente zur verwendung damit |
US9233023B2 (en) | 2007-03-13 | 2016-01-12 | Optimedica Corporation | Method and apparatus for creating ocular surgical and relaxing incisions |
US7753953B1 (en) | 2007-03-30 | 2010-07-13 | Kingman Yee | Accommodating intraocular lens system |
US8314927B2 (en) | 2007-07-23 | 2012-11-20 | Powervision, Inc. | Systems and methods for testing intraocular lenses |
WO2009015161A2 (en) | 2007-07-23 | 2009-01-29 | Powervision, Inc. | Lens material with uv initiator and uv absorber and methods of curing with uv light |
WO2009015240A2 (en) | 2007-07-23 | 2009-01-29 | Powervision, Inc. | Lens delivery system |
EP2178462B1 (en) * | 2007-07-23 | 2014-04-02 | PowerVision, Inc. | Post-implant lens power modification |
US8668734B2 (en) | 2010-07-09 | 2014-03-11 | Powervision, Inc. | Intraocular lens delivery devices and methods of use |
EP2671541B1 (en) | 2007-07-23 | 2019-04-17 | PowerVision, Inc. | Accommodating intraocular lenses |
US9610155B2 (en) | 2008-07-23 | 2017-04-04 | Powervision, Inc. | Intraocular lens loading systems and methods of use |
US8968396B2 (en) | 2007-07-23 | 2015-03-03 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
US8579971B2 (en) * | 2007-08-13 | 2013-11-12 | Garth T. Webb | Inflatable intra ocular lens/lens retainer |
US8377124B2 (en) | 2007-10-02 | 2013-02-19 | Novartis Ag | Two-element system to provide an ease of accommodation with variable-spherical aberration control |
US9717589B2 (en) | 2007-10-15 | 2017-08-01 | Akkolens International B.V. | Adjustable accommodating intraocular lens and positioning means |
US8012204B2 (en) | 2007-11-14 | 2011-09-06 | Novartis Ag | Accommodative intraocular lens system |
US9156949B2 (en) | 2007-12-21 | 2015-10-13 | Abbott Medical Optics Inc. | Silicone containing polymeric materials |
US8414646B2 (en) | 2007-12-27 | 2013-04-09 | Forsight Labs, Llc | Intraocular, accommodating lens and methods of use |
EP3381407A1 (en) | 2008-01-03 | 2018-10-03 | Forsight Labs, Llc | Intraocular, accomodating lens and methods of use |
US20090198326A1 (en) | 2008-01-31 | 2009-08-06 | Medennium Inc. | Accommodative intraocular lens system |
US7998198B2 (en) | 2008-02-07 | 2011-08-16 | Novartis Ag | Accommodative IOL with dynamic spherical aberration |
US8254034B1 (en) | 2008-03-31 | 2012-08-28 | Rhevision Technology, Inc. | Fluidic adaptive lens with a lens membrane having suppressed fluid permeability |
EP2315559B1 (en) | 2008-07-24 | 2012-01-25 | Nulens Ltd | Accommodating intraocular lens (aiol) capsules |
RU2011119513A (ru) | 2008-10-15 | 2012-11-27 | Алькон, Инк. | Аккомодирующая внутриглазная линза |
US20120232649A1 (en) | 2008-11-20 | 2012-09-13 | Insight Innovations, Llc | Intraocular Lens Cell Migration Inhibition System |
WO2010062972A1 (en) | 2008-11-26 | 2010-06-03 | Anew Optics, Inc. | Intraocular lens optic |
US10299913B2 (en) | 2009-01-09 | 2019-05-28 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
WO2010081093A2 (en) | 2009-01-09 | 2010-07-15 | Powervision, Inc. | Intraocular lenses and methods of accounting for capsule size variability and post-implant changes in the eye |
US8858626B2 (en) | 2009-02-10 | 2014-10-14 | Novartis Ag | Accommodative intraocular lens system |
US8222360B2 (en) | 2009-02-13 | 2012-07-17 | Visiogen, Inc. | Copolymers for intraocular lens systems |
US8657878B2 (en) | 2009-02-18 | 2014-02-25 | Hoya Corporation | Interfacial refraction accommodating lens (IRAL) |
US20100211169A1 (en) | 2009-02-19 | 2010-08-19 | Daniel Walter Stanley | Intraocular lens configured to offset optical effects caused by optic deformation |
US20100288346A1 (en) | 2009-04-29 | 2010-11-18 | Gobi Ramakrishnan Padmanabhan | Configurations and methods to manufacture solar cell device with larger capture cross section and higher optical utilization efficiency |
US8320049B2 (en) | 2009-07-15 | 2012-11-27 | The Penn State Research Foundation | Tunable liquid gradient refractive index lens device |
US20110029074A1 (en) | 2009-08-03 | 2011-02-03 | Abbott Medical Optics Inc. | Fixation of ophthalmic implants |
WO2011026068A2 (en) | 2009-08-31 | 2011-03-03 | Powervision, Inc. | Lens capsule size estimation |
US20110071628A1 (en) | 2009-09-24 | 2011-03-24 | Rainbow Medical Ltd. | Accommodative intraocular lens |
WO2011053143A1 (en) | 2009-10-30 | 2011-05-05 | Akkolens International B.V. | Intraocular lenses for variable focus |
US9114005B2 (en) | 2009-11-17 | 2015-08-25 | Akkolens International B.V. | Accommodative intraocular lens driven by ciliary mass |
WO2011062826A2 (en) | 2009-11-17 | 2011-05-26 | Lu Kenneth L | Accommodating intraocular lens |
US8357196B2 (en) | 2009-11-18 | 2013-01-22 | Abbott Medical Optics Inc. | Mark for intraocular lenses |
US20120245683A1 (en) * | 2009-12-04 | 2012-09-27 | Acufocus, Inc. | Corneal implant for refractive correction |
GB2476480B (en) | 2009-12-22 | 2013-04-03 | Marwan Ghabra | Intraocular implant with a fixed and a pivoting lens |
WO2011094139A1 (en) | 2010-01-26 | 2011-08-04 | Klein, David | Accommodating intraocular lens |
JP2013520291A (ja) | 2010-02-23 | 2013-06-06 | パワーヴィジョン・インコーポレーテッド | 遠近調節型眼内レンズのための液体 |
DE202010003217U1 (de) | 2010-03-05 | 2011-08-04 | Fluoron Gmbh | Füllmaterial für ophthalmologische Implantate |
US9034035B2 (en) | 2010-03-16 | 2015-05-19 | Mor Research Applications Ltd. | Accommodating intraocular lens assembly |
WO2011137191A1 (en) | 2010-04-27 | 2011-11-03 | Ramgopal Rao | Accommodating intraocular lens device |
US10736732B2 (en) | 2010-06-21 | 2020-08-11 | James Stuart Cumming | Intraocular lens with longitudinally rigid plate haptic |
WO2012006186A2 (en) | 2010-06-29 | 2012-01-12 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Accommodating intraocular lens with deformable material |
EP2582325A1 (en) | 2010-08-15 | 2013-04-24 | Nulens Ltd | Discrete pre-assembled monolithic aiol assemblages and aiol assemblies including same |
US9744028B2 (en) | 2011-02-03 | 2017-08-29 | Akkolens International B.V. | Haptic combinations for accommodating intraocular lenses |
WO2012106673A1 (en) | 2011-02-04 | 2012-08-09 | Forsight Labs, Llc | Intraocular accommodating lens |
US8867141B2 (en) | 2011-03-18 | 2014-10-21 | Johnson & Johnson Vision Care, Inc. | Lens with multi-concave meniscus wall |
US9943405B2 (en) | 2011-05-16 | 2018-04-17 | Ico, Inc. | Filling and implanting accommodative intraocular lenses |
US20140227437A1 (en) | 2011-05-23 | 2014-08-14 | California Institute Of Technology | Accommodating intraocular lens |
US8715345B2 (en) | 2011-05-23 | 2014-05-06 | California Institute Of Technology | Accommodating intraocular lens |
US8771347B2 (en) | 2011-05-23 | 2014-07-08 | California Institute Of Technology | Accommodating intraocular lens |
US9186243B2 (en) | 2011-05-31 | 2015-11-17 | Novartis Ag | Accommodative intraocular lens and method of implantation |
US8257827B1 (en) | 2011-06-02 | 2012-09-04 | The Regents Of The University Of California | Silicone composition and devices incorporating same |
US8608800B2 (en) | 2011-08-02 | 2013-12-17 | Valdemar Portney | Switchable diffractive accommodating lens |
WO2013016804A1 (en) | 2011-08-03 | 2013-02-07 | Webb Garth T | Negatively pressurized deformable lens |
KR101866873B1 (ko) | 2011-08-09 | 2018-06-14 | 삼성전자주식회사 | 곡률 조절 소자 및 방법 |
JP5594262B2 (ja) | 2011-08-29 | 2014-09-24 | 信越化学工業株式会社 | 液状付加硬化型フロロシリコーンゴム組成物及びその成形品 |
US20130110234A1 (en) | 2011-10-28 | 2013-05-02 | Lauren DeVita | Dual optic accommodating iol with low refractive index gap material |
US10433949B2 (en) | 2011-11-08 | 2019-10-08 | Powervision, Inc. | Accommodating intraocular lenses |
DK2775961T3 (en) | 2011-11-08 | 2019-04-15 | Powervision Inc | Accommodating intraocular lenses |
US9364319B2 (en) | 2012-09-25 | 2016-06-14 | Valdemar Portney | Refractive-diffractive switchable optical element |
US9364316B1 (en) | 2012-01-24 | 2016-06-14 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US10080648B2 (en) | 2012-01-24 | 2018-09-25 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
WO2013112589A1 (en) | 2012-01-24 | 2013-08-01 | Regents Of The University Of Colorado | Modular intraocular lens designs and methods |
US10028824B2 (en) | 2012-01-24 | 2018-07-24 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US8500806B1 (en) | 2012-01-31 | 2013-08-06 | Andrew F. Phillips | Accommodating intraocular lens |
US8900300B1 (en) | 2012-02-22 | 2014-12-02 | Omega Ophthalmics Llc | Prosthetic capsular bag and method of inserting the same |
EP2827804B1 (en) | 2012-03-21 | 2024-04-03 | Alcon Inc. | Intraocular lens delivery systems |
US20150105760A1 (en) | 2012-04-30 | 2015-04-16 | Lensgen, Inc. | Method and system for adjusting the refractive power of an implanted intraocular lens |
US9084674B2 (en) | 2012-05-02 | 2015-07-21 | Abbott Medical Optics Inc. | Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity |
WO2013176979A1 (en) | 2012-05-25 | 2013-11-28 | California Institute Of Technology | Accommodating intraocular composite lens and related methods |
JP5872964B2 (ja) | 2012-05-29 | 2016-03-01 | 東レ・ダウコーニング株式会社 | 導電性室温硬化型フルオロシリコーンゴム組成物 |
FR2992215B1 (fr) | 2012-06-21 | 2014-10-31 | Oreal | Composition cosmetique anhydre comprenant une huile, des particules d'aerogel de silice hydrophobe, un actif hydrophile et au moins un agent tensioactif |
DE102012016892A1 (de) | 2012-08-24 | 2014-02-27 | Be Innovative Gmbh | Intraokularlinse, insbesondere Ziliarintraokularlinse |
DE102012016893A1 (de) | 2012-08-24 | 2014-05-15 | Be Innovative Gmbh | Intraokularlinse, insbesondere Kapselsackintraokularlinse |
US9622855B2 (en) | 2012-10-08 | 2017-04-18 | Valdemar Portney | Remote multifocal to monofocal optic conversion |
US20140107459A1 (en) | 2012-10-11 | 2014-04-17 | Alcon Research, Ltd. | Devices, systems, and methods for intraocular measurements |
WO2014063135A2 (en) | 2012-10-19 | 2014-04-24 | 1Co, Inc. | Systems and methods for customizing adjustable intraocular lenses |
WO2014070331A1 (en) | 2012-10-31 | 2014-05-08 | Novartis Ag | Accommodating intraocular lens with ciliary body activation |
US20140135917A1 (en) | 2012-11-13 | 2014-05-15 | Vision Solutions Technologies, Inc. | Multi-focus intraocular prosthesis |
US9090033B2 (en) | 2012-12-18 | 2015-07-28 | Novartis Ag | Presbyopia-correcting IOL using curvature change of an air chamber |
US20140180406A1 (en) | 2012-12-21 | 2014-06-26 | Novartis Ag | Accommodating intraocular lens |
US20140180410A1 (en) | 2012-12-21 | 2014-06-26 | Novartis Ag | Intraocular lens or lens system to provide monofocal vision at multiple pre-defined focal points |
RU2015123463A (ru) | 2012-12-21 | 2017-01-27 | Новартис Аг | Аккомодационная интраокулярная линза с изменяемой кривизной |
BR112015014486A2 (pt) | 2012-12-21 | 2017-07-11 | Novartis Ag | lente intraocular acomodativa de mudança de curvatura |
US9186244B2 (en) | 2012-12-21 | 2015-11-17 | Lensgen, Inc. | Accommodating intraocular lens |
US20140309734A1 (en) | 2012-12-26 | 2014-10-16 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US20140180407A1 (en) | 2012-12-26 | 2014-06-26 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US9925039B2 (en) | 2012-12-26 | 2018-03-27 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US9486311B2 (en) | 2013-02-14 | 2016-11-08 | Shifamed Holdings, Llc | Hydrophilic AIOL with bonding |
EP2945571B1 (en) | 2013-02-28 | 2018-04-25 | HONIGSBAUM, Richard F. | Tensioning rings for anterior capsules and accommodative intraocular lenses for use therewith |
US20140257478A1 (en) | 2013-03-07 | 2014-09-11 | Sean J. McCafferty | Accommodating fluidic intraocular lens with flexible interior membrane |
US20140257479A1 (en) | 2013-03-11 | 2014-09-11 | Sean J. McCafferty | Refocusable intraocular lens with flexible aspherical surface |
US9277988B1 (en) | 2013-03-15 | 2016-03-08 | Milton W. Chu | Intraocular lenses with quantum dots |
JP6717740B2 (ja) | 2013-03-15 | 2020-07-01 | パワーヴィジョン・インコーポレーテッド | 眼内レンズの収容および載置装置ならびにその使用方法 |
US10195018B2 (en) | 2013-03-21 | 2019-02-05 | Shifamed Holdings, Llc | Accommodating intraocular lens |
CN107961101B (zh) | 2013-03-21 | 2019-12-27 | 施菲姆德控股有限责任公司 | 调节性人工晶状体 |
DE102014106374A1 (de) | 2013-05-07 | 2014-11-13 | Akkolens International B.V. | Akkommodierende intraokulare Linse mit Sulcusfixierungshaptiken |
CA2913897C (en) | 2013-06-03 | 2018-02-20 | Clarvista Medical, Inc. | Intraocular lens system |
WO2015030262A1 (en) | 2013-08-28 | 2015-03-05 | Dow Corning Toray Co., Ltd. | Curable silicone composition, cured product thereof, and optical semiconductor device |
EP2851038A1 (en) | 2013-09-24 | 2015-03-25 | Consejo Superior De Investigaciones Cientificas | Intraocular lens with accomodation capacity |
CN109806027A (zh) | 2013-11-01 | 2019-05-28 | 雷恩斯根公司 | 双部件调节性人工晶状体设备 |
WO2015066502A1 (en) | 2013-11-01 | 2015-05-07 | Thomas Silvestrini | Accomodating intraocular lens device |
EP3071678A1 (en) | 2013-11-20 | 2016-09-28 | Dow Corning Corporation | Organosiloxane compositions |
WO2015094485A1 (en) | 2013-12-20 | 2015-06-25 | Novartis Ag | Accommodating intraocular lens |
WO2015099879A2 (en) | 2013-12-23 | 2015-07-02 | Novartis Ag | Accommodating intraocular lens |
JP2017505702A (ja) | 2014-02-18 | 2017-02-23 | クラービスタ メディカル, インコーポレイテッドClarvista Medical, Inc. | モジュール式眼内レンズの設計、器具および方法 |
JP6410850B2 (ja) | 2014-03-07 | 2018-10-24 | コネクサス レンズ インコーポレイテッド | 相互圧平性内面を有する再合焦可能なレンズシステム |
US9333072B2 (en) | 2014-04-29 | 2016-05-10 | Chukyo Medical Co., Inc. | Intraocular lens |
WO2015195825A1 (en) | 2014-06-19 | 2015-12-23 | Omega Ophthalmics Llc | Prostheticcapsular devices, systems, and methods |
US10004596B2 (en) | 2014-07-31 | 2018-06-26 | Lensgen, Inc. | Accommodating intraocular lens device |
US20160051361A1 (en) | 2014-08-21 | 2016-02-25 | Emmetrope Incorporated | Accommodating Intraocular Lens |
CN107106293B (zh) | 2014-08-26 | 2019-07-12 | 施菲姆德控股有限责任公司 | 调节性人工晶状体 |
JP6754755B2 (ja) | 2014-09-23 | 2020-09-16 | レンスゲン、インコーポレイテッド | 調節性眼内レンズ用の高分子材料 |
US10265163B2 (en) | 2014-12-27 | 2019-04-23 | Jitander Dudee | Accommodating intraocular lens assembly |
CA2974639A1 (en) | 2015-01-30 | 2016-08-04 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US9358103B1 (en) | 2015-02-10 | 2016-06-07 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
JP6660640B2 (ja) | 2015-02-16 | 2020-03-11 | アルコン インコーポレイティド | 膨張可能な周辺貯蔵部を備える曲率変化調節可能眼内レンズ |
CA2973684C (en) | 2015-03-03 | 2023-03-14 | Novartis Ag | Dual optic, curvature changing accommodative iol |
WO2016160952A1 (en) | 2015-03-30 | 2016-10-06 | Wendian Shi | Fluid-filled implantable structures with internal surface-modifying components and related methods |
US20180153682A1 (en) | 2015-06-10 | 2018-06-07 | Powervision, Inc. | Intraocular lens materials and components |
CN113730030A (zh) | 2015-11-04 | 2021-12-03 | 克拉维斯塔医疗有限公司 | 模块化人工晶状体设计、工具和方法 |
CN108348328B (zh) | 2015-11-06 | 2020-04-10 | 力景公司 | 可调节人工晶状体和制造方法 |
ES2617579B1 (es) | 2015-11-16 | 2018-04-10 | Lens Undergone Zonula Global, S.L. | Lente intraocular acomodativa mejorada |
WO2017087358A1 (en) | 2015-11-18 | 2017-05-26 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lens |
CN113180886A (zh) | 2015-12-01 | 2021-07-30 | 雷恩斯根公司 | 调节性人工晶状体装置 |
US9931202B2 (en) | 2016-03-08 | 2018-04-03 | Novartis Ag | Dual optic, curvature changing accommodative IOL having a fixed disaccommodated refractive state |
US11045309B2 (en) | 2016-05-05 | 2021-06-29 | The Regents Of The University Of Colorado | Intraocular lens designs for improved stability |
JP2019519664A (ja) | 2016-05-27 | 2019-07-11 | レンズジェン、インコーポレイテッド | 眼内レンズデバイス用の分子量分布の狭いレンズオイル |
CA3026494C (en) | 2016-06-06 | 2022-06-07 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
US10159566B2 (en) | 2016-09-26 | 2018-12-25 | Novartis Ag | Heat tunable intraocular lens |
CA3040281C (en) | 2016-10-21 | 2021-04-13 | Omega Ophthalmics Llc | Prosthetic capsular devices |
EA037705B1 (ru) | 2016-10-28 | 2021-05-12 | Форсайт Вижн6, Инк. | Аккомодационный искусственный хрусталик и система для имплантации в глаз |
EP3558163A4 (en) | 2016-12-23 | 2020-05-27 | Shifamed Holdings, LLC | MULTI-PIECE ACCOMMODATIVE INTRAOCULAR LENSES AND METHODS OF MAKING AND USING THE SAME |
US10350056B2 (en) | 2016-12-23 | 2019-07-16 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lenses and methods for making and using same |
CN110621261A (zh) | 2017-03-13 | 2019-12-27 | 凯亚可公司 | 调节性晶状体装置 |
US10918476B2 (en) | 2017-03-30 | 2021-02-16 | Verily Life Sciences Llc | Electrowetting intraocular lens with isotonic aqueous phase |
US11409134B2 (en) | 2017-04-19 | 2022-08-09 | Amo Groningen B.V. | Electrowetting and photo curing for manufacturing of ophthalmic lenses |
US11197752B2 (en) | 2017-05-05 | 2021-12-14 | Verily Life Sciences Llc | Situ filling and sealing of electrowetting intraocular lenses |
CN110996848B (zh) | 2017-05-30 | 2023-08-04 | 施菲姆德控股有限责任公司 | 调节性人工晶状体的表面处理以及相关方法和装置 |
AU2018279101B2 (en) | 2017-06-07 | 2023-07-13 | Shifamed Holdings, Llc | Adjustable optical power intraocular lenses |
US11382736B2 (en) | 2017-06-27 | 2022-07-12 | Alcon Inc. | Injector, intraocular lens system, and related methods |
US10716661B2 (en) | 2017-07-17 | 2020-07-21 | Verily Life Sciences Llc | Accommodating intraocular lens with meniscus |
US20200253723A1 (en) | 2017-07-31 | 2020-08-13 | Douglas Michael Ackermann | Pupillary accommodating intraocular lens |
US20190069989A1 (en) | 2017-09-06 | 2019-03-07 | Verily Life Sciences Llc | Multipart electrowetting intraocular lens for in-situ assembly |
WO2019236908A1 (en) | 2018-06-07 | 2019-12-12 | Lensgen, Inc. | Intraocular lens devices and related methods |
-
2011
- 2011-04-27 WO PCT/US2011/034197 patent/WO2011137191A1/en active Application Filing
- 2011-04-27 EP EP11775538.9A patent/EP2563275A4/en not_active Withdrawn
- 2011-04-27 JP JP2013508225A patent/JP2013525028A/ja active Pending
- 2011-04-27 CN CN201180021257XA patent/CN102883682A/zh active Pending
-
2012
- 2012-10-26 US US13/662,087 patent/US20130053954A1/en not_active Abandoned
-
2018
- 2018-06-01 US US15/995,671 patent/US10772721B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4932966A (en) * | 1988-08-15 | 1990-06-12 | Storz Instrument Company | Accommodating intraocular lens |
US5275623A (en) * | 1991-11-18 | 1994-01-04 | Faezeh Sarfarazi | Elliptical accommodative intraocular lens for small incision surgery |
CN1379644A (zh) * | 1999-09-10 | 2002-11-13 | 兰多·伍兹 | 具有调节能力的植入式眼内人工晶状体 |
US20070021831A1 (en) * | 2005-07-19 | 2007-01-25 | Clarke Gerald P | Accommodating intraocular lens and methods of use |
CN101277659A (zh) * | 2005-09-28 | 2008-10-01 | 兴和株式会社 | 眼内透镜 |
US20090319040A1 (en) * | 2006-09-16 | 2009-12-24 | Elie Khoury | Accommodative intra-ocular lens |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106535823A (zh) * | 2014-07-31 | 2017-03-22 | 雷恩斯根公司 | 调节眼内晶状体装置 |
CN106535823B (zh) * | 2014-07-31 | 2019-07-19 | 雷恩斯根公司 | 调节眼内晶状体装置 |
CN110279494A (zh) * | 2014-08-26 | 2019-09-27 | 施菲姆德控股有限责任公司 | 调节性人工晶状体 |
CN107708615A (zh) * | 2015-05-01 | 2018-02-16 | 麦迪凯姆眼科(塞浦路斯)有限公司 | 用于经由眼睛球面像差的定制化而优化视觉的方法和装置 |
CN107847316A (zh) * | 2015-05-28 | 2018-03-27 | 阿维·哈达德 | 眼内晶状体以及用于调节现有的自适应眼内晶状体的方法 |
CN109789012A (zh) * | 2016-05-27 | 2019-05-21 | 雷恩斯根公司 | 用于眼内晶状体装置的具有窄分子量分布的晶状体油 |
CN110996850A (zh) * | 2017-06-07 | 2020-04-10 | 施菲姆德控股有限责任公司 | 可调节光学度数的眼内透镜 |
CN108272534A (zh) * | 2018-01-23 | 2018-07-13 | 上海理工大学 | 一种可连续变焦的人工晶状体 |
CN115245404A (zh) * | 2021-04-27 | 2022-10-28 | 卡尔蔡司医疗技术股份公司 | 用于生产可调节人工晶状体的方法 |
CN115245404B (zh) * | 2021-04-27 | 2024-03-19 | 卡尔蔡司医疗技术股份公司 | 用于生产可调节人工晶状体的方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2011137191A1 (en) | 2011-11-03 |
US20190000612A1 (en) | 2019-01-03 |
US20130053954A1 (en) | 2013-02-28 |
EP2563275A4 (en) | 2017-11-22 |
JP2013525028A (ja) | 2013-06-20 |
EP2563275A1 (en) | 2013-03-06 |
US10772721B2 (en) | 2020-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10772721B2 (en) | Accommodating intraocular lens | |
JP6564031B2 (ja) | 調節性曲率変化眼内レンズ | |
EP2945569B1 (en) | Bioanalogic intraocular lens | |
US8475529B2 (en) | Accommodating intraocular lens | |
US9078744B2 (en) | Single optic accommodative intraocular lens system | |
CN101861133B (zh) | 调节型人工晶状体系统 | |
US6299641B1 (en) | Intraocular lens implant having eye accommodating capabilities | |
US7025783B2 (en) | Accommodating intraocular lens with integral capsular bag ring | |
AU2003286723B2 (en) | Accomodating intraocular lens implant | |
CA2549203C (en) | Intraocular lens implant having posterior bendable optic | |
US20060212116A1 (en) | Capsular intraocular lens implant having a refractive liquid therein | |
TW201632151A (zh) | 雙鏡片、曲率變化調節式iol | |
CN104619287A (zh) | 人工晶体,尤其是囊袋人工晶体 | |
CN103561684A (zh) | 调节性眼内透镜和植入方法 | |
CN105073066A (zh) | 可调节人工晶状体 | |
JP2023158112A (ja) | 眼鏡なしの調節レンズ | |
CN101534748A (zh) | 多目镜的人工晶状体系统 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130116 |