CN102871853B

CN102871853B - Composition for enhancing and prolonging cooling feeling and application thereof

Info

Publication number: CN102871853B
Application number: CN201210362871.9A
Authority: CN
Inventors: 戎伟; 金家骅; 杜子荣
Original assignee: Shanghai Zhonghua Pharmaceutical CO Ltd
Current assignee: Shanghai Zhonghua Pharmaceutical CO Ltd
Priority date: 2012-09-25
Filing date: 2012-09-25
Publication date: 2015-02-04
Anticipated expiration: 2032-09-25
Also published as: CN102871853A

Abstract

The invention aims to disclose a composition for enhancing and prolonging a cooling feeling and application thereof. The composition comprises the following components in percentage by mass: 40 to 80 percent of borneol, 10 to 50 percent of mint amide and 5 to 30 percent of butyl vanillin. Compared with the prior art, the composition has the advantages that the borneol, the butyl vanillin and the mint amide are combined, so the cooling degree is effectively enhanced, and the cooling duration is prolonged; and a skin-care product manufactured by using the composition for enhancing and prolonging the cooling feeling has a cool sense, brings continual cooling and refreshing feeling besides moisturizing and nourishing and is mild, safe and stimulation-free in the absence of any artificial essence, and the aims of the composition are fulfilled.

Description

A kind ofly strengthen and extend compositions and the application thereof of refrigerant sense

Technical field

The present invention relates to a kind of compositions and application thereof, particularly a kind of be applicable to skin care item enhancing and extend compositions and the application thereof of refrigerant sense.

Background technology

In summer, freshener is a lot of in the application of skin care item, and the energy adjustment body lotion of nursing gel, Lancome and the mousse Cleansing Foam of Dior etc. after such as lucky palpus, be subject to some and like liking of the consumer of refrigerant impression.

The at present freshener mainly menthyl lactate that uses of these products on the market, its persistence has certain effect, but explosive and refrigerant degree is inadequate.

People are in order to obtain the product and Mentholum of having to add that burst is strong and refrigerant degree is high, but because the Mentholum refrigerant persistent period is shorter, in order to continue the refrigerant addition that must improve it, but its characteristic odor will be denseer like this, make the covering of fragrance to it have sizable difficulty, thus damage the image of high-grade skin care item.

Therefore, special needs a kind ofly strengthens and extends compositions and the application thereof of refrigerant sense, has solved above-mentioned existing Problems existing.

Summary of the invention

The object of the present invention is to provide and a kind ofly strengthen and extend compositions and the application thereof of refrigerant sense, for the deficiencies in the prior art, effectively strengthen refrigerant degree, extend refrigerant persistence, meet the refrigerant skin care item development requirement of each class.

Technical problem solved by the invention can realize by the following technical solutions:

On the one hand, the invention provides and a kind ofly strengthen and extend the compositions of refrigerant sense, it is characterized in that, it comprises the component of following mass percent: Borneolum Syntheticum 40-80%, amide of mint 10-50% and butyl Rhizoma et radix valerianae ester 5-30%.

In one embodiment of the invention, preferably, Borneolum Syntheticum is 50-70%, and amide of mint is 25-40%, and butyl Rhizoma et radix valerianae ester is 10-20%.

On the other hand, the invention provides and a kind ofly strengthen and extend the application of the compositions of refrigerant sense, it is characterized in that, described enhancing also extends the application of compositions in the skin care item such as Cool cream of refrigerant sense.

Enhancing of the present invention also extends compositions and the application thereof of refrigerant sense, compared with prior art, by the combination of Borneolum Syntheticum, butyl Rhizoma et radix valerianae ester and amide of mint, effectively strengthen refrigerant degree, extend refrigerant persistence, use enhancing of the present invention and the skin care item extending the compositions manufacture of refrigerant sense have ice feels well texture, refrigerant impression of soothing the spirit endlessly is brought while moisturizing, do not add any artificial essence, gentle safe and non-stimulating, realize object of the present invention.

The detailed description and obtaining that feature of the present invention can consult the graphic and following better embodiment of this case is well understood to.

Accompanying drawing explanation

Fig. 1 is the schematic diagram of Cooling intensity in embodiments of the invention;

Fig. 2 is the schematic diagram of calorific intensity in embodiments of the invention;

Fig. 3 is the schematic diagram of refrigerant persistent period in embodiments of the invention.

Detailed description of the invention

The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with concrete diagram, setting forth the present invention further.

On the one hand, enhancing of the present invention also extends the compositions of refrigerant sense, and it comprises the component of following mass percent: Borneolum Syntheticum 40-80%, amide of mint 10-50% and butyl Rhizoma et radix valerianae ester 5-30%.

Preferably, Borneolum Syntheticum is 50-70%, and amide of mint is 25-40%, and butyl Rhizoma et radix valerianae ester is 10-20%.

Borneolum Syntheticum, its characteristic: clearing heat for detumescence; Penetration enhancing effect; Coordinate Mentholum, can suitably increase refrigerant sense.

Amide of mint, its characteristic: cooling sensation is stable and enhancing at leisure; Without mint flavored; Extend refrigerant.

Butyl Rhizoma et radix valerianae ester, its characteristic: intense warmth; Comparatively other exothermic mixture safety; Low irritant; Long-acting hotness; Blood circulation promoting; Menthol and butyl Rhizoma et radix valerianae ester with the use of, its creeping chill intensity can be strengthened, extend the creeping chill time simultaneously.

Enhancing of the present invention the compositions extending refrigerant sense can play according to the principle of refrigerant illusion and strengthen and the effect extended further.

Amide of mint is a kind of exothermic mixture, research conclusion: the amide of mint of 0.5% can promote that local blood circulation amount increases by 66.4%, and immediately effectively, after 10 minutes, obvious onset, reached peak value after 30 minutes.

Conclusion is that hemoperfusion amount rising effective time length was more than 30 minutes.Say from angles of product, refrigerant sense stiffening effect continues more than 30 minutes.The actual test of sample according to 1%, effective time reaches 120 minutes.But owing to being exothermic mixture, if dosage is excessive, can manifest heating effect in the latter stage that refrigerant sense disappears, these needs are avoided.

On the other hand, enhancing of the present invention also extends the application of the compositions of refrigerant sense, and described enhancing also extends the application of compositions in the skin care item such as Cool cream of refrigerant sense.

Enhancing of the present invention to extend the compositions of refrigerant sense as follows for the preparation of the step of skin care item:

1, the preparation in early stage:

Oil phase: take the octadecanol of formula ratio, Emulium Delta, glyceryl monostearate, Mentholum, isononyl isononanoate, IPM in beaker respectively, in temperature 70 C ~ 80, DEG C heating is also stirred to a little and melts completely, for subsequent use.

Aqueous phase: take deionized water and Acritamer 940 in proportion in beaker, rapid stirring disperses and is heated to 70 DEG C ~ 80 DEG C, for subsequent use.

Borneolum Syntheticum, amide of mint, butyl Rhizoma et radix valerianae ester, D5, sodium hydroxide solution, antiseptic GPL is taken by formula ratio, for subsequent use.

2, preparation skin care articles:

Borneolum Syntheticum, amide of mint are added above-mentioned high temperature oil phase, is stirred to dissolving, more slowly pour oil phase into aqueous phase and stir, first stir 5 minutes, then homogenizing 2 minutes.

Insulation 15 minutes is stirred at about 75 DEG C.

Begin to cool down, temperature of charge in emulsifying pot is down to 60 DEG C, adds D5.

Be cooled to 50 DEG C, add sodium hydroxide solution.

Be cooled to 40 DEG C, add butyl Rhizoma et radix valerianae ester and GPL stirs 15 minutes, close and stir, complete.

Test recipe designs: on basic components basis, add the Borneolum Syntheticum of different proportion, butyl Rhizoma et radix valerianae ester, amide of mint, and gained sample arises from inboard arm with standard substance one and smears and carry out contrast test.

Verification method:

Clinical trial

Scheme-IN VIVO tests:

20 experimenters through training

Test sample:

Standard substance (not containing the o/w cream frost of refrigerant combination) VS. contains the o/w cream frost of refrigerant combination

Experimental condition: between 12 independently room (temperature and moisture constant)

Apply 2 test samples (standard substance and the cream frost containing refrigerant combination) at both sides forearm simultaneously

Timing is started after application testing sample, when first 10 minutes, the refrigerant sense intensity of assess sample.Continue test subsequently until refrigerant sense disappears, timing, if now there is heating sense to produce, record its calorific intensity in the lump.

Cool cream orthogonal test is as following table:

Cool feeling standards of grading: (see Fig. 1)

0=does not have refrigerant sense

The refrigerant sense that 10=is strong

Hotness standards of grading (see Fig. 2)

0=does not generate heat sense

The heating sense that 10=is strong

The refrigerant persistent period (see Fig. 3)

Checking conclusion:

By obtaining a kind of not only acomia hotness to the orthonormal design of experiments of Cool cream but also can strengthening and extend the portfolio ratio of refrigerant sense, accounting is respectively: Borneolum Syntheticum 40-80%, amide of mint 10-50%, butyl Rhizoma et radix valerianae ester 5-30%

Best proportion is: Borneolum Syntheticum 50-70%, amide of mint 25-40%, butyl Rhizoma et radix valerianae ester 10-20%.

The pH value of this Cool cream is 6.56, and by stability experiment, its result meets QB/T1857-2004.

More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications; these changes and improvements all fall in the claimed scope of the invention, and application claims protection domain is defined by appending claims and equivalent thereof.

Claims

1. a Cool cream, is characterized in that, it comprises and a kind ofly has the compositions strengthening and extend refrigerant sense, said composition is made up of the component of following mass percent: Borneolum Syntheticum 50-70%, amide of mint 25-40%, butyl Rhizoma et radix valerianae ester 10-20%, the mass percent summation of each component is 100%; Its preparation process is as follows:

(1) preparation in early stage:

Oil phase: take the octadecanol of formula ratio, Emulium Delta, glyceryl monostearate, Mentholum, isononyl isononanoate, isopropyl myristate in beaker respectively, in temperature 70 C ~ 80, DEG C heating is also stirred to a little and melts completely, for subsequent use;

Aqueous phase: take deionized water and Acritamer 940 in proportion in beaker, rapid stirring disperses and is heated to 70 DEG C ~ 80 DEG C, for subsequent use;

Borneolum Syntheticum, amide of mint, butyl Rhizoma et radix valerianae ester, ring five polydimethylsiloxane, sodium hydroxide solution, antiseptic GPL is taken by formula ratio, for subsequent use;

(2) preparation skin care articles:

Borneolum Syntheticum, amide of mint are added above-mentioned high temperature oil phase, is stirred to dissolving, more slowly pour oil phase into aqueous phase and stir, first stir 5 minutes, then homogenizing 2 minutes; Insulation 15 minutes is stirred at 75 DEG C; Begin to cool down, temperature of charge in emulsifying pot is down to 60 DEG C, add ring five polydimethylsiloxane; Be cooled to 50 DEG C, add sodium hydroxide solution; Be cooled to 40 DEG C, add butyl Rhizoma et radix valerianae ester and antiseptic GPL stirs 15 minutes, close and stir, complete.