CN102727938A - Radioactive biodegradable bile duct stent and preparation method thereof - Google Patents
Radioactive biodegradable bile duct stent and preparation method thereof Download PDFInfo
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- CN102727938A CN102727938A CN2012100292890A CN201210029289A CN102727938A CN 102727938 A CN102727938 A CN 102727938A CN 2012100292890 A CN2012100292890 A CN 2012100292890A CN 201210029289 A CN201210029289 A CN 201210029289A CN 102727938 A CN102727938 A CN 102727938A
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- degraded
- biliary tract
- radiolabeled biotin
- tract prosthesis
- support
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Abstract
The invention, belonging to the field of biomedicine and high polymer material, relates to a radioactive biodegradable bile duct stent and a preparation method thereof. The radioactive biodegradable bile duct stent is a hollow tubular stent comprising biocompatible high-molecular degradable material and radioactive substance, is characterized in that the two ends are provided with barbed reverse beards, and accords with the anatomic characteristics of human pancreatic duct. The radioactive biodegradable bile duct stent disclosed herein can carry out radiosurgery on the tumors locally, especially for treating pancreaticobiliary malignancies, can reduce systemic side effect caused by radiosurgery while raising the curative effect, can be degraded in a certain time with no toxicity and no harm, can avoid continuous stimulation of permanent stents to lumen and organs in the body, and can avoid restenosis. The radioactive biodegradable bile duct stent has the advantages of simple preparation method, low price of materials, and strong practicality.
Description
Technical field
The invention belongs to biomedical sector and polymeric material field, relate to a kind of radiolabeled biotin degraded biliary tract prosthesis and preparation method thereof, be specifically related to that a kind of to can be used for treating the pancreas gallbladder be radiolabeled biotin degraded biliary tract prosthesis of malignant tumor and preparation method thereof.
Background technology
The pancreas gallbladder is that malignant tumor companion pancreatic duct blocks is clinical common disease, has very high sickness rate; Its onset concealment belongs to late period mostly during discovery, be associated with tangible pancreatic duct and block, and clinical manifestations such as cholestasis, obstructive pancreatitis occur, and about 60～70% patients have lost the chance of surgical radical treatment when making a definite diagnosis; Other has weak with age or concurrent other organ serious diseases of some patients also can only take non-operation palliative treatment.And the palliative treatment method mainly is to remove pancreatic duct to block, guarantee that drain is common at present, comprising: whole body or intravascular get involved chemotherapy, radiotherapy, surgery through abdomen gallbladder intestinal or Pancreaticoenterostomy or the like, but side effect is too big; Therefore, the pancreatic duct support is inserted drainage under the current common employing scope.
There is following defective in the support pancreatic duct support of present clinical use: though said support can improve drain; The development of uncontrollable tumor; Often the continuous hypertrophy because of tumor occurs once more narrow; Therefore, support is changed or inserted once more to many needs of patients times without number, finally causes the state of an illness to worsen rapidly; In addition, many supports are difficult to take out when the pancreatic duct restenosis occurring, mainly due to putting histio-irritative hypertrophy in frame position or the remarkable hypertrophy of tumor tissues, and closely are entrenched togather with support, increase the weight of narrow.
Summary of the invention
The objective of the invention is to overcome the defective and the deficiency of prior art, a kind of radiolabeled biotin degraded biliary tract prosthesis and preparation method thereof is provided, be specifically related to that a kind of to be used to treat the pancreas gallbladder be radiolabeled biotin degraded biliary tract prosthesis of malignant tumor and preparation method thereof.
Radiolabeled biotin of the present invention degraded biliary tract prosthesis can be in the part to suffering from tumor carry out radiotherapy, in the raising curative effect, reduce radiocurable systemic side effects; Described radiolabeled biotin degraded support, it can be degraded within a certain period of time, avoids the lasting stimulation of permanent stents to luminal organs in the body, thereby reduces the hypertrophy pathological reaction of local anomaly, avoids taking place behind the restenosis and increases the weight of to block.
Particularly, radiolabeled biotin degraded biliary tract prosthesis of the present invention is characterized in that, is processed by biocompatibility macromolecule degradation material and radioactive substance.
Described radiolabeled biotin degraded biliary tract prosthesis is the piped support of intermediate hollow, and it meets the pancreaticobiliary anatomic characteristic of human body;
Among the present invention, the anti-palpus of barb-like is established at its two ends of described radiolabeled biotin degraded biliary tract prosthesis.
Among the present invention, described biocompatibility macromolecule degradation material is selected from polylactic acid, and any in polycaprolactone or the polyurethane perhaps is selected from any two copolymers of these materials, perhaps three kinds copolymer;
Among the present invention, described radioactive substance is selected from the half-life less than 3 months radioactive substance, and in one embodiment of the present of invention, described radioactive substance is an iodine 125.
The present invention further provides the method for preparing of described radiolabeled biotin degraded biliary tract prosthesis, it is characterized in that it comprises step:
(1) adopt biocompatibility macromolecule degradation material and radioactive substance, mix by a certain percentage as required mixture;
(2) adopt double screw extruder to push said mixture, process the piped support of the intermediate hollow that meets the pancreaticobiliary anatomic characteristic of human body;
(3) above-mentioned tubular bracket two ends are made the anti-palpus of barb-like, make radiolabeled biotin degraded biliary tract prosthesis.
Among the present invention, biliary tract prosthesis that can make as required or ductus pancreaticus support.
Method for preparing of the present invention is simple, material price is cheap, practical; The radioactivity biliary tract prosthesis that makes is that radiopharmaceutical and biological degradable material are combined; Has the radiotherapy function of tumor; Along with the carrying out of treatment, this support is degraded at certain hour, and catabolite is nontoxic simultaneously; Can be external through the metabolism eliminating, radioactive material is along with treatment disappears; It is malignant tumor that described radiolabeled biotin degraded support can be used for treating the pancreas gallbladder.
For the ease of understanding, through specific embodiment radiolabeled biotin degraded biliary tract prosthesis of the present invention is carried out detailed description below.What need particularly point out is, specific embodiment only is in order to explain that obviously those skilled in the art can explain according to this paper, and the present invention is carried out various corrections or change, and these corrections and changing also will be included within the scope.
Specific embodiments
Embodiment 1
At first, polylactic acid is mixed with iodine 125 by a certain percentage; Then; Said mixture is pushed with double screw extruder; According to the pancreaticobiliary anatomic characteristic of human body, process the piped support of intermediate hollow, wherein; The overall diameter of the biliary tract prosthesis that makes is that 1.3cm, interior diameter are that 0.6cm, length are 7cm, and the overall diameter of the ductus pancreaticus support that makes is that 0.8cm, interior diameter are that 0.4cm, length are 6cm; At last, cutting falling of into thick 0.1cm, wide 0.3cm in four places that apart from above-mentioned tubular bracket each 1.5cm of two ends, orientation are 0 point, 3 points, and at 6 at 9 to two ends must (falls must length be 0.7cm), processes radiolabeled biotin degraded biliary tract prosthesis.
Embodiment 2
Polycaprolactone, polyurethane and iodine 125 are mixed by a certain percentage; Said mixture is pushed with double screw extruder; According to the pancreaticobiliary anatomic characteristic of human body; Process the piped support of intermediate hollow; Wherein, the overall diameter of the biliary tract prosthesis that makes is that 1.3cm, interior diameter are that 0.6cm, length are 7cm, and the overall diameter of the ductus pancreaticus support that makes is that 0.8cm, interior diameter are that 0.4cm, length are 6cm; Cutting falling of into thick 0.1cm, wide about 0.3cm in four places that apart from above-mentioned tubular bracket each 1.5cm of two ends, orientation are 0 point, 3 points, and at 6 at 9 to two ends must (falls must length be 0.8cm), processes the radiolabeled biotin biliary tract prosthesis of degrading.
Embodiment 3
Polycaprolactone, polyurethane, polyurethane and iodine 125 are mixed by a certain percentage; Said mixture is pushed with double screw extruder; According to the pancreaticobiliary anatomic characteristic of human body; Process the piped support of intermediate hollow; Wherein, the overall diameter of the biliary tract prosthesis that makes is that 1.2cm, interior diameter are that 0.6cm, length are 7cm, and the overall diameter of the ductus pancreaticus support that makes is that 0.8cm, interior diameter are that 0.4cm, length are 6cm; Cut falling of into thick 0.1cm, wide 0.3cm apart from four places of above-mentioned tubular bracket each 1.5cm of two ends, orientation 0 point, 3 points, and to two ends at 6 at 9 must (fall must length be 0.6cm), process radiolabeled biotin degraded biliary tract prosthesis.
Embodiment 4
The radioactivity biliary tract prosthesis that makes experimentizes on probation, and being used to treat the pancreas gallbladder is malignant tumor, and the result shows; This radioactivity biliary tract prosthesis has the radiotherapy function of tumor; Along with the carrying out of treatment, this support is degraded at certain hour, and catabolite is nontoxic; Can be external through the metabolism eliminating, through the radioactive material of test disappearing along with treatment.
Result on trial shows, described radiolabeled biotin degraded biliary tract prosthesis, and method for preparing is simple, material price is cheap, practical.
Claims (8)
1. a radiolabeled biotin degraded biliary tract prosthesis is characterized in that, is processed by biocompatibility macromolecule degradation material and radioactive substance, and described radiolabeled biotin degraded support is the piped support of intermediate hollow, and the anti-palpus of barb-like is established at its two ends.
2. by the described radiolabeled biotin of claim 1 degraded biliary tract prosthesis, it is characterized in that described biocompatibility macromolecule degradation material is selected from polylactic acid, any in polycaprolactone or the polyurethane, or the copolymer of any two copolymers or three kinds wherein.
3. by the described radiolabeled biotin of claim 1 degraded biliary tract prosthesis, it is characterized in that described radioactive substance is selected from the half-life less than 3 months radioactive substance.
4. by claim 1 or 3 described radiolabeled biotin degraded biliary tract prosthesises, it is characterized in that described radioactive substance is an iodine 125.
5. by the described radiolabeled biotin degraded of claim 1 biliary tract prosthesis, it is characterized in that described support
Overall diameter is that 1.2-1.3cm, interior diameter are that 0.6cm, length are 7cm, or overall diameter is that 0.8cm, interior diameter are that 0.4cm, length are 6cm; The anti-of described barb-like must length be 0.6cm-0.8cm.
6. the method for preparing of the described radiolabeled biotin of claim 1 degraded biliary tract prosthesis is characterized in that it comprises step:
(1) adopts biocompatibility macromolecule degradation material and radioactive substance, make mixture by required mixed;
(2) said mixture is pushed with double screw extruder, process the piped support of intermediate hollow;
(3) the tubular bracket two ends of step (2) are established the anti-palpus of barb-like, make radiolabeled biotin degraded biliary tract prosthesis.
7. by the described method for preparing of claim 5, it is characterized in that, make radiolabeled biotin degraded biliary tract prosthesis and meet the pancreaticobiliary anatomic characteristic of human body.
8. the described radiolabeled biotin degraded of claim 1 biliary tract prosthesis is treated the purposes in the support that the pancreas gallbladder is a malignant tumor in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100292890A CN102727938A (en) | 2011-10-28 | 2012-02-09 | Radioactive biodegradable bile duct stent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110337692.5 | 2011-10-28 | ||
| CN201110337692 | 2011-10-28 | ||
| CN2012100292890A CN102727938A (en) | 2011-10-28 | 2012-02-09 | Radioactive biodegradable bile duct stent and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102727938A true CN102727938A (en) | 2012-10-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012100292890A Pending CN102727938A (en) | 2011-10-28 | 2012-02-09 | Radioactive biodegradable bile duct stent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251110A (en) * | 2015-11-10 | 2016-01-20 | 北京工业大学 | Assembling device and method in radioactive seed stent |
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| CN1470294A (en) * | 2003-07-07 | 2004-01-28 | �й���ѧԺ����Ӧ�û�ѧ�о��� | Biodegradable common bile duct built-in carriage and its making method |
| CN1927421A (en) * | 2006-09-21 | 2007-03-14 | 中国人民解放军第二军医大学 | Pipe support capable of load-bearing minisize active particle source |
| CN1961977A (en) * | 2006-11-16 | 2007-05-16 | 沈阳 | Degradable radioactive biliary stent and method for producing the same |
| US20080103584A1 (en) * | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
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2012
- 2012-02-09 CN CN2012100292890A patent/CN102727938A/en active Pending
Patent Citations (6)
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| US5670161A (en) * | 1996-05-28 | 1997-09-23 | Healy; Kevin E. | Biodegradable stent |
| WO2001049340A1 (en) * | 1999-12-30 | 2001-07-12 | Advanced Cardiovascular Systems, Inc. | Stent with radiopaque coating consisting of particles in a binder |
| CN1470294A (en) * | 2003-07-07 | 2004-01-28 | �й���ѧԺ����Ӧ�û�ѧ�о��� | Biodegradable common bile duct built-in carriage and its making method |
| CN1927421A (en) * | 2006-09-21 | 2007-03-14 | 中国人民解放军第二军医大学 | Pipe support capable of load-bearing minisize active particle source |
| US20080103584A1 (en) * | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
| CN1961977A (en) * | 2006-11-16 | 2007-05-16 | 沈阳 | Degradable radioactive biliary stent and method for producing the same |
Non-Patent Citations (4)
| Title |
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| 《 Gastrointestinal Endoscopy》 20090331 Yan Liu等 "A novel approach for treatment of unresectable extrahepatic bile duct carcinoma: design of radioactive stents and an experimental trial in healthy pigs" 第517-524页 1-8 第69卷, 第3期 * |
| 《中华消化杂志》 20071231 刘军楼等 "放射性塑料胆管支架的实验研究" 第797-800页 1-8 第27卷, 第12期 * |
| YAN LIU等: ""A novel approach for treatment of unresectable extrahepatic bile duct carcinoma: design of radioactive stents and an experimental trial in healthy pigs"", 《 GASTROINTESTINAL ENDOSCOPY》 * |
| 刘军楼等: ""放射性塑料胆管支架的实验研究"", 《中华消化杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251110A (en) * | 2015-11-10 | 2016-01-20 | 北京工业大学 | Assembling device and method in radioactive seed stent |
| CN105251110B (en) * | 2015-11-10 | 2018-04-17 | 北京工业大学 | A kind of device and assembly method for assembling in radioactive particle stent |
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Application publication date: 20121017 |