CN102697513A - Automatic sampling and dosing system for animals - Google Patents

Automatic sampling and dosing system for animals Download PDF

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Publication number
CN102697513A
CN102697513A CN2012101932061A CN201210193206A CN102697513A CN 102697513 A CN102697513 A CN 102697513A CN 2012101932061 A CN2012101932061 A CN 2012101932061A CN 201210193206 A CN201210193206 A CN 201210193206A CN 102697513 A CN102697513 A CN 102697513A
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sampling
drug
supplying system
interface
port
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CN2012101932061A
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CN102697513B (en
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董超
柯远楠
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SHANGHAI RUIMAN INFORMATION TECHNOLOGY CO LTD
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SHANGHAI RUIMAN INFORMATION TECHNOLOGY CO LTD
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Abstract

The invention provides an automatic sampling and dosing system for animals. The automatic sampling and dosing system comprises a sampling system, a universal interface, a dosing system, a control system and a power system, wherein the sampling system and the dosing system are connected to the universal interface; the power system is used for driving the sampling system to execute sampling actions and driving the dosing system to execute dosing actions; and the control system is used for controlling the sampling process of the sampling system and the dosing process of the dosing system by controlling the power system. The automatic sampling and dosing system has the functions of automatically collecting blood and injecting medicaments, can regularly and quantitatively sample or inject according to the experimental requirements and accurately record experiment data, and can be widely applied to various experimental animals such as mice, rats, cats, dogs, pigs and the like. According to the automatic sampling and dosing system, the sampling success rate in more than 95 percent, and the samples can be automatically resampled even if the sampling fails; and the volume of collected blood can reach 5 microliters at least, so that the damage to the experimental animals is reduced to the minimum, and small animals can be selected to replace big animals.

Description

The animal drug-supplying system of sampling automatically
Technical field
The present invention relates to animal experiment utensil, particularly, relate to a kind of animal drug-supplying system of sampling automatically.
Background technology
In the scientific research of subjects such as medical science and the research, often need experimentize, the test of animal is taken a blood sample to animal, and give animal medicine feed or injectable drug with animals such as rat, mice, rabbits.Sampling apparatus of the prior art to be sampled into power low, and be difficult to accomplish trace blood, existing and can not accomplish sampling, can accomplish the device of administration again in the prior art in same system.
Summary of the invention
To defective of the prior art, the purpose of this invention is to provide a kind of animal drug-supplying system of sampling automatically.
According to an aspect of the present invention; A kind of animal drug-supplying system of sampling automatically is provided; Comprise sampling system, universal interface, drug-supplying system, control system, dynamical system; Wherein, Said sampling system and drug-supplying system are connected to said universal interface, and said dynamical system is used to drive said sampling system to be carried out sampling action and drive said drug-supplying system execution administration action, and said control system is used for controlling the sampling process of said sampling system and the administration process of said drug-supplying system through controlling said dynamical system.
Preferably; Said sampling system comprises injection device and storage device, and wherein, the sampling input of said injection device connects said universal interface; Said storage device connects said injection device, is used to collect the liquid that said injection device is gathered; Also as the part of said drug-supplying system, like the part of injection device as drug-supplying system, then drug-supplying system is the automatic chemical feeding system to said injection device as the part of said sampling system the time.
Preferably; Said injection device comprises syringe, syringe positioning seat, locating groove; Said syringe is fixed on the said syringe positioning seat through said locating groove, and said dynamical system is used to drive the injection handle completion push pull maneuver of said syringe, and said dynamical system comprises motor, travelling gear, screw rod, slide, guide rod, leader fixed; Wherein, Said motor drives said screw rod rotation through travelling gear, and an end of said screw rod connects said slide, and said slide is installed on the said guide rod, can slides along said guide rod; Said guide rod is installed between the said leader fixed and syringe positioning seat, and the slide draw-in groove of said slide is located the injection handle of said syringe.
Preferably; Said universal interface comprises shell, outfan interface, equipment end interface and adapter sleeve; Wherein, be connected through said adapter sleeve between the inner port of said outfan interface in said shell and the inner port of said equipment end interface in said shell.
Preferably, said outfan interface can be that rotating shaft freely rotates with its axis.
Preferably, said universal interface also comprises following any or any two devices :-device folder, and wherein, said device folder is installed in the external port of said equipment end interface, and wherein, the external port of said equipment end interface is positioned at the outside of said shell;-vessel clamp, wherein, said vessel clamp is installed on said outfan interface.
Preferably; Also comprise conduit; Wherein, said conduit extends to the far distance port of said sheathed catheter from the external port of said outfan interface through the proximal port of said sheathed catheter, and the external port of the proximal port of said sheathed catheter and said outfan interface lays respectively at the both sides of said vessel clamp.
Preferably, also comprise autonomous drug-supplying system, wherein; Said autonomous drug-supplying system comprises doser, and said doser comprises support and be installed in medicine box, rolling disc, fixed disk, motor, the delivery tube on the said support, wherein; The medicine outlet of said medicine box is close to the upper surface of said rolling disc, and the upper surface of said fixed disk is close to the lower surface of said rolling disc, and said rolling disc is provided with the drug storage mouth; Said fixed disk is provided with drug delivery port; The upper end of said delivery tube be positioned at said drug delivery port under, said rolling disc is installed on the output shaft of said motor, said control system connects said motor.
Preferably; Said rolling disc can rotate between the primary importance and the second position; When said rolling disc is positioned at said primary importance; Said drug storage mouth be positioned at said medicine box medicine outlet under, when said rolling disc is positioned at the said second position, said drug storage mouth be positioned at said drug delivery port directly over.
Preferably, said autonomous drug-supplying system also comprises flip flop equipment, and wherein said flip flop equipment is positioned at the porch of said support; Said flip flop equipment comprises shell; Said shell is provided with the triggering window, and said triggering window is provided with sensing device, and said sensing device connects said control system.
Compared with prior art, the present invention is by PC software records data, and control dynamical system driving syringe pump carries out drug administration by injection or extraction is sampled, and syringe pump is connected with universal interface with animal.When native system during in injection pattern, directly liquid in the syringe is injected in the animal body, when native system during in sampling configuration, syringe extracts liquid in syringe, and the storage device that reinjects is preserved.
Further, the function of automatic blood sampling of the present invention and injectable drug can be sampled or injects and accurately write down experimental data according to requirement of experiment at regular time and quantity, can be widely used in various laboratory animals like mice, rat, cat, Canis familiaris L., pig etc.It is sampled into power more than 95%, even sampling failure also can be adopted automatically again.The minimum amount of adopting that can reach 5 microlitres of blood sampling volume, the injury to laboratory animal has also reduced to minimum like this, and can select toy to replace large animal.In sampling process, instrument is quantitative sampling as requested, and blood unnecessary in the conduit can return in the animal body with normal saline automatically, in case the stop thing is fainted.Adopt low temperature storage device to prevent sample reaction, rotten, guarantee to test smoothly and accomplish.In whole sampling process, animal is unconstrained, can be movable freely in cage.Simultaneously, native system can adopt the automatic chemical feeding system, also can adopt autonomous drug-supplying system; If adopt the automatic chemical feeding system; Then sampling and administration are integrated in the same injection device, if adopt autonomous drug-supplying system, then sampling apparatus works alone with autonomous drug-supplying system.In addition, the present invention has powerful software support, and all processes are all accomplished sampling process automatically by computer control and can be obtained and saved manpower and time greatly than the more accurate effectively numerical value of artificial sample.
Description of drawings
Through reading the detailed description of non-limiting example being done with reference to following accompanying drawing, it is more obvious that other features, objects and advantages of the present invention will become:
Fig. 1 illustrates according to system block diagram of the present invention;
Fig. 2 illustrates the structural representation according to injection device of the present invention;
Fig. 3 illustrates the cross-sectional view according to universal interface of the present invention;
Fig. 4 illustrates the contour structures sketch map according to universal interface of the present invention;
Fig. 5 illustrates the structural representation according to autonomous drug-supplying system of the present invention;
Fig. 6 illustrates the structural representation according to flip flop equipment in the autonomous drug-supplying system of the present invention.
The specific embodiment
According to the animal provided by the invention drug-supplying system of sampling automatically; Comprise sampling system 2, universal interface 3, drug-supplying system, control system 1, dynamical system; Wherein, Said sampling system and drug-supplying system are connected to said universal interface; Said dynamical system is used to drive said sampling system to be carried out sampling action and drives said drug-supplying system execution administration action, and said control system is used for controlling the sampling process of said sampling system and the administration process of said drug-supplying system through controlling said dynamical system.
Preferably; Said sampling system comprises injection device and storage device 4; Wherein, The sampling input of said injection device connects said universal interface, and said storage device connects said injection device, is used to collect the liquid that said injection device is gathered, said injection device as the part of said sampling system the time also as the part of said drug-supplying system.
Wherein, Said sampling system comprises injection device and dynamical system; Wherein, Said injection device comprises syringe 209, syringe positioning seat 2010, test rod 208; Locating groove 207, said dynamical system are used to drive the injection handle completion push pull maneuver (the blood drawing function is perhaps when its injectable drug function as the automatic chemical feeding system when being used to accomplish as sampling system) of said syringe, and said dynamical system comprises motor 201, travelling gear 202, screw rod 2011, slide 205, guide rod 204, leader fixed 203.
Particularly, said syringe is fixed on the said syringe positioning seat through said locating groove, and said test rod is used to detect the diameter of said syringe.Said motor drives said screw rod rotation through travelling gear; One end of said screw rod connects said slide; Said slide is installed on the said guide rod, can slides along said guide rod; Said guide rod is installed between the said leader fixed and syringe positioning seat, the injection handle of the said syringe in slide draw-in groove 206 location of said slide.
In a preference of present embodiment; The present invention is through said dynamical system; Make the push pull maneuver of syringe under the control of control device, to realize accurately push pull maneuver through motor; Thereby guaranteed the accuracy of collection capacity and injection volume, be particularly suitable for trace and gather or administration.More particularly, said travelling gear is a reduction gearing.Said motor is a motor.Said control device connects said motor.
Said universal interface; Comprise shell 303, outfan interface 308, equipment end interface 302, adapter sleeve 309, device folder 301, vessel clamp 304, sheathed catheter 306 and conduit; Wherein, be connected through said adapter sleeve 309 between the inner port of said outfan interface 308 in said shell 303 and the inner port of said equipment end interface 302 in said shell 303.Said outfan interface 308, shell 303, equipment end interface 302 and adapter sleeve 309 coaxial settings.Said outfan interface 308 can be that rotating shaft freely rotates with its axis.Said adapter sleeve 309 is processed by polytetrafluoroethylmaterial material.
Be connected through the adapter sleeve of processing by polytetrafluoroethylmaterial material 309 between outfan interface 308 of the present invention and the equipment end interface 302; But adapter sleeve 309 high temperature sterilizes; Characteristics with antiacid alkali resistant, anti-various organic solvents; Thereby guaranteed requirement of experiment, and this material friction coefficient is extremely low, also guaranteed this device freely rotate smooth and easy.
More particularly, said device folder 301 is installed in the external port of said equipment end interface 302, and wherein, the external port of said equipment end interface 302 is positioned at the outside of said shell.Said vessel clamp 304 is installed on said outfan interface 308.Said sheathed catheter 306 is installed on said vessel clamp 304, and said outfan interface 308 and said sheathed catheter 306 are separately fixed at the two ends of said vessel clamp 304, and is fixing with first set bolt 307 and second set bolt 305 respectively.
Further, the external port of the proximal port 3061 of said sheathed catheter 306 and said outfan interface 308 lays respectively at the both sides of said vessel clamp 304.Said conduit extends to the far distance port 3062 of said sheathed catheter 306 through the proximal port 3061 of said sheathed catheter 306 from the external port of said outfan interface 308.Said equipment end interface connects in said outer casing screw.
Present embodiment applies in the zoopery; The present invention in use; Draw guiding tube by syringe and insert said equipment end interface 302; Said conduit is drawn by said outfan interface 308, penetrates the said sheathed catheter 306 from said sheathed catheter 306 upper ends, is connected on the animal body from the far distance port 3062 of said sheathed catheter 306.Animal can be free movable, and sheathed catheter can freely rotate around the axle of universal interface.
Said autonomous drug-supplying system; Comprise doser, said doser comprises support 502 and is installed in medicine box 501, rolling disc 504, fixed disk 505, motor 506, the delivery tube 507 on the said support 502, wherein; The medicine outlet of said medicine box 501 is close to the upper surface of said rolling disc 504; The upper surface of said fixed disk 505 is close to the lower surface of said rolling disc 504, and said rolling disc 504 is provided with drug storage mouth 509, and said fixed disk 505 is provided with drug delivery port 508; The upper end of said delivery tube 507 be positioned at said drug delivery port 508 under, said rolling disc 504 is installed on the output shaft of said motor 506.
More particularly; Said rolling disc 504 can rotate between the primary importance and the second position; When said rolling disc 504 is positioned at said primary importance; Said drug storage mouth 509 be positioned at said medicine box 501 medicine outlet under, when said rolling disc 504 is positioned at the said second position, said drug storage mouth 509 be positioned at said drug delivery port 508 directly over.
Further, said autonomous drug-supplying system also comprises flip flop equipment, and wherein said flip flop equipment is positioned at the porch of said support 502.Said flip flop equipment comprises shell 5010, and said shell 5010 is provided with and triggers window 5012, and said triggering window 5012 is provided with sensing device.Preferably, said sensing device comprises infrared emission tube 5011 and infrared receiver tube 5013.
In a preferred specific embodiment of the present invention, put into medicine box 501 to pill 503 earlier, when getting into, animal limb triggers window 5012; Interrupt the infrared ray of infrared emission tube 5011, make infrared receiver tube 5013 not receive signal, at this moment host computer sends a signal and gives motor 506; Motor 506 drive rolling discs 504 revolve and turn around, and pill 503 gets into drug storage mouths 509 when 509 mouthfuls of drug storages rotate to medicine box 501 belows, because of drug storage mouth 509 is slightly larger than pill; Have only a pill to get into the drug storage mouth fully; Because of the resistance of other pill and medicine box 501 box walls, finally have only a pill to be brought into drug delivery port 8 by drug storage mouth 509, pill drops to the delivery tube 507 from drug delivery port 508; Along delivery tube 507, pill is sent to the place that animal can be had.
More than specific embodiment of the present invention is described.It will be appreciated that the present invention is not limited to above-mentioned specific implementations, those skilled in the art can make various distortion or modification within the scope of the claims, and this does not influence flesh and blood of the present invention.

Claims (10)

1. animal drug-supplying system of sampling automatically; It is characterized in that; Comprise sampling system, universal interface, drug-supplying system, control system, dynamical system; Wherein, Said sampling system and drug-supplying system are connected to said universal interface, and said dynamical system is used to drive said sampling system to be carried out sampling action and drive said drug-supplying system execution administration action, and said control system is used for controlling the automatic sampling process of said sampling system and the automatic chemical feeding process of said drug-supplying system through controlling said dynamical system.
2. the animal according to claim 1 drug-supplying system of sampling automatically; It is characterized in that; Said sampling system comprises injection device and storage device, and wherein, the sampling input of said injection device connects said universal interface; Said storage device connects said injection device, is used to collect the liquid that said injection device is gathered, said injection device as the part of said sampling system the time also as the part of said drug-supplying system.
3. the animal according to claim 2 drug-supplying system of sampling automatically; It is characterized in that said injection device comprises syringe, syringe positioning seat, locating groove, said syringe is fixed on the said syringe positioning seat through said locating groove; Said dynamical system is used to drive the injection handle completion push pull maneuver of said syringe; Said dynamical system comprises motor, travelling gear, screw rod, slide, guide rod, leader fixed, and wherein, said motor drives said screw rod rotation through travelling gear; One end of said screw rod connects said slide; Said slide is installed on the said guide rod, can slides along said guide rod, and said guide rod is installed between the said leader fixed and syringe positioning seat, and the slide draw-in groove of said slide is located the injection handle of said syringe.
4. the animal according to claim 1 drug-supplying system of sampling automatically; It is characterized in that; Said universal interface comprises shell, outfan interface, equipment end interface and adapter sleeve; Wherein, be connected through said adapter sleeve between the inner port of said outfan interface in said shell and the inner port of said equipment end interface in said shell.
5. the animal according to claim 4 drug-supplying system of sampling automatically is characterized in that said outfan interface can be that rotating shaft freely rotates with its axis.
6. the animal according to claim 4 drug-supplying system of sampling automatically is characterized in that, said universal interface also comprises following any or any two devices:
-device folder, wherein, said device folder is installed in the external port of said equipment end interface, and wherein, the external port of said equipment end interface is positioned at the outside of said shell;
-vessel clamp, wherein, said vessel clamp is installed on said outfan interface.
7. the animal according to claim 6 drug-supplying system of sampling automatically; It is characterized in that; Also comprise conduit; Wherein, said conduit extends to the far distance port of said sheathed catheter from the external port of said outfan interface through the proximal port of said sheathed catheter, and the external port of the proximal port of said sheathed catheter and said outfan interface lays respectively at the both sides of said vessel clamp.
8. the animal according to claim 1 drug-supplying system of sampling automatically is characterized in that, also comprises autonomous drug-supplying system; Wherein, said autonomous drug-supplying system comprises doser, and said doser comprises support and is installed in medicine box, rolling disc, fixed disk, motor, the delivery tube on the said support; Wherein, The medicine outlet of said medicine box is close to the upper surface of said rolling disc, and the upper surface of said fixed disk is close to the lower surface of said rolling disc, and said rolling disc is provided with the drug storage mouth; Said fixed disk is provided with drug delivery port; The upper end of said delivery tube be positioned at said drug delivery port under, said rolling disc is installed on the output shaft of said motor, said control system connects said motor.
9. the animal according to claim 8 drug-supplying system of sampling automatically; It is characterized in that; Said rolling disc can rotate between the primary importance and the second position, when said rolling disc is positioned at said primary importance, said drug storage mouth be positioned at said medicine box medicine outlet under; When said rolling disc is positioned at the said second position, said drug storage mouth be positioned at said drug delivery port directly over.
10. the animal according to claim 8 drug-supplying system of sampling automatically; It is characterized in that said autonomous drug-supplying system also comprises flip flop equipment, wherein said flip flop equipment is positioned at the porch of said support; Said flip flop equipment comprises shell; Said shell is provided with the triggering window, and said triggering window is provided with sensing device, and said sensing device connects said control system.
CN201210193206.1A 2012-06-12 2012-06-12 Animal is sampled delivery system automatically Expired - Fee Related CN102697513B (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103389229A (en) * 2013-07-16 2013-11-13 环境保护部南京环境科学研究所 Automatic collection device of gas
CN103932681A (en) * 2014-04-13 2014-07-23 曹春杰 Bleeding time monitor
CN104688379A (en) * 2015-03-22 2015-06-10 河北工业大学 Livestock and poultry disease preventing and curing medicine feeding device using drinking water
CN105213063A (en) * 2014-06-24 2016-01-06 上海益诺思生物技术有限公司 Sd rat continuous intravenous injection equipment
CN106510728A (en) * 2016-09-22 2017-03-22 重庆开奇科技发展有限公司 Novel trace quantitative blood collection tube device

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US6062224A (en) * 1997-04-17 2000-05-16 Bioanalytical Systems, Inc. Movement-response system for conducting tests on freely-moving animals
US20090018505A1 (en) * 2003-08-11 2009-01-15 Andrew Arguedas Powered automatic injection device
CN202740008U (en) * 2012-06-12 2013-02-20 上海瑞曼信息科技有限公司 Automatic sampling and dosing system for animals

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5269762A (en) * 1992-04-21 1993-12-14 Sterling Winthrop, Inc. Portable hand-held power assister device
CN2151724Y (en) * 1992-11-18 1994-01-05 陈恂 Adjustable continuous injector for animal
US6062224A (en) * 1997-04-17 2000-05-16 Bioanalytical Systems, Inc. Movement-response system for conducting tests on freely-moving animals
US20090018505A1 (en) * 2003-08-11 2009-01-15 Andrew Arguedas Powered automatic injection device
CN202740008U (en) * 2012-06-12 2013-02-20 上海瑞曼信息科技有限公司 Automatic sampling and dosing system for animals

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103389229A (en) * 2013-07-16 2013-11-13 环境保护部南京环境科学研究所 Automatic collection device of gas
CN103932681A (en) * 2014-04-13 2014-07-23 曹春杰 Bleeding time monitor
CN103932681B (en) * 2014-04-13 2016-05-04 曹春杰 bleeding time monitor
CN105213063A (en) * 2014-06-24 2016-01-06 上海益诺思生物技术有限公司 Sd rat continuous intravenous injection equipment
CN104688379A (en) * 2015-03-22 2015-06-10 河北工业大学 Livestock and poultry disease preventing and curing medicine feeding device using drinking water
CN104688379B (en) * 2015-03-22 2016-05-11 河北工业大学 The livestock and poultry drinking water medicine feed device of preventing and curing diseases
CN106510728A (en) * 2016-09-22 2017-03-22 重庆开奇科技发展有限公司 Novel trace quantitative blood collection tube device

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