CN102639168A - Irrigation and aspiration devices and methods - Google Patents

Abstract

Irrigation and/or aspiration devices and methods may be configured to aspirate and irrigate alone, sequentially, or concurrently. The devices and methods may provide a base with a removable head, and adapted for partial or complete separation of the irrigation and aspiration functions. The devices and methods can be configured to aspirate and/or irrigate the nasal and sinus cavities. The devices and methods may be manually and/or automatically controlled. The devices and methods may include removable, and/or replaceable, and/or refillable, and easily cleanable reservoirs for aspirant and irrigant. The device head and/or aspirant reservoir may comprise a diagnostic device, i.e., test device and/or container after use of the devices and methods.

Description

The I & A device and method

Related application

The application is the common unsettled U.S. Patent application of submitting on November 6th, 2007 the 11/936th that is entitled as " Irrigation and AspirationDevice and Method (I & A device and method) "; No. 042 part continuation application; It requires the U.S. Provisional Application the 60/857th of submission on November 6th, 2006; The priority that No. the 60/944th, 079, the U.S. Provisional Application of submitting in No. 457 and on June 14th, 2007.

Technical field

Present invention relates in general to medical domain, relate more specifically to cavity, that is, nasal cavity attracts and flushing, as under medical environment and nasal cavity cleaning that carries out at home and attraction.Especially, apparatus of the present invention and method can be carried out simultaneously through one or more nozzles or conduit and attract and flushing.These two actions can be through separately control or the control simultaneously of one or more switches.

Background technology

Nasal cavity and congestion of nasal sinus are ubiquitous problems in child and adult.Have every year about 1,000,000 Americans viral disease can occur and environment allergy causes various symptoms, comprise rhinitis (being nasal cavity inflammation), this can cause hyperemia, rhinorrhea and sinus block.And this can cause sinusitis conversely, or more common, causes stimulation, pain and congestion, causes baby sleep and feed situation bad thus, and adult's general malaise and dispirited.

The diagnosis of many potential patient's condition is at most loaded down with trivial details process.Must take out mucus and/or nasal cavity tissue, and be placed in bottle or the shuttle.Usually sample is delivered to laboratory then and be used for analyzing, this can spend several hours, or could obtain the result for more time, and provides therapeutic scheme.

The current strategies of handling nasal cavity and congestion of nasal sinus comprises oral and nonprescription drugs such as decongestant and hydryllin the nasal administration few types, and prescription drugs such as steroid and antibiotic.Though these solutions have certain mitigation, also can bring serious defective: they are very expensive, and the result is uncertain, and has side effect, comprise that the hyperemia of bounce-back property, hypertension, custom form and possible drug interaction.In department of pediatrics, be not proved to be nonprescription drugs safely and effectively.Also can partly alleviate hyperemia, but this air blowing finally can cause stimulation to the adult, and very difficult enforcement can't be implemented maybe for child or baby through blowing to nose.

Owing to these reasons, the doctor turns to the ancient Therapeutic Method that uses normal saline washing just gradually.Recently, several doctor association is appointed as complementary therapy with normal saline flushing in its practical criterion, and nasal cavity and irrigation of sinuses be method commonly used at present, especially in department of pediatrics.Yet,, still do not have ideal system to can be used for carrying out this kind treatment at present though people constantly increase the concern of brine treatment.

Proved independent nose suction, or the nose of behind normal saline washing, carrying out suction is a kind of effective means of alleviating the rhinitis sings and symptoms.Nose suction can evade the zest that side effects of pharmaceutical drugs and nasal cavity blow-or nasal cavity blow can't implementation.Manually suction pump is used for the suction of baby's nose already.But they can not provide enough air flows, and competent evacuation time can not be provided.Therefore, their usefulness is uncertain, and may use inconvenience, and is disappointing.The problem of pain when the typical irrigation of sinuses device that design supplies the sinusitis adult patient to use can't be evaded aerofluxus or air blowing.

In addition, because the baby is obligate nasal respiration person (obligate nose breather), the nasal congestion that is therefore caused by viral respiratory tract infection can cause baby sleep and feed difficulty.This will cause malnutrition and restless, may damage child's health, upset the running of family.Worse, still unsolved nasal congestion is as the syndromic part of baby virus, can cause need emergency department go to a doctor or hospitalization with supplemental oxygen, frequent suction and parenteral absorption.

Several kinds of strategies are used to solve nasal congestion.Some researchs prove, and less than effect, and most of head of a family knows that nasal irrigation and suction are best choice to coldrex for relief of symptoms.The symptom that conventional nasal irrigation can improve the adult who suffers from chronic sinusitis and suffer from the child of allergic rhinitis.In addition, some researchs have proved that normal saline washing can improve the nose ciliary movement.Think saline from mucosa down with adventitial space the sucking-off fluid, thereby reduce air flue edema and softening mucus, make to aspirate to be easier to.In addition, think that saline has stimulated the passage in the cell membrane, this has improved cell function.

This of normal saline washing and suction kind of combination is proved to be useful, especially for the baby who suffers from bronchiolitis.Central authorities' " wall type " suction of hospital is used in the great majority research of estimating the nose suction, some researchs even use dark nasopharynx suction, and this dual mode all can't be used for clinic and family usually.This studies proof, and suitable suction can reduce the needs of further intervention, like atomizing, supplemental oxygen be in hospital.

Opposite with the suction of hospital wall type, manually the snuffing lead device can be used for domestic. applications.Their peak suction and flow velocity generally are enough, but their air flow is uncontrolled, be difficult to keep nostril sealing and very of short duration, thus they need be from nose times without number shift-in shift out.These two parameters make their quality defectiveness, bigger pressure prove optimum (for example, 80 to 100mmHg), and the persistent period of their effects is short, need make repeated attempts to and fro, and this makes their use inconvenience.

Typical spherical aspirator can provide suction to a certain degree, but of short duration and uncontrolled pressure limit their practicality.In addition, this elongated bar might cause mucosa injury and make nostril (nasal meatus) sealing insufficient.Some manual suction pumps have been evaded this problem through the nose tip preferably that exploitation has improved sealing and a safety.

Therefore, still need have the nozzle that improves sealing, and the modifying device and the method that can attract simultaneously and wash through nozzle.Still needs can provide diagnostic function; And attracting and wash action can be by the operator through single controller (promptly; Switch) modifying device and the method for control are so that these apparatus and method can and comprise that baby's child provides faster and better ease for use for the adult.

Summary of the invention

The invention provides the modifying device and the method that are used for the health that comprises opening, aperture, cavity, inner chamber, blood vessel or pleat (fold) is provided flushing and/or attraction.

One aspect of the present invention provides and has been used to send and/or removes fluidic device.This device comprises shell, be positioned at shell be suitable for hold the irrigation storage of flush fluid and be positioned at shell be suitable for hold attract fluidic attractant (aspirant) storage.Barrier device can be suitable for institute is attracted liquid to be retained in the attractant storage and lets gas flow out from the attractant storage.At least one nozzle can stretch out from shell; This nozzle comprises irrigation inner chamber and attractant inner chamber; This irrigation inner chamber is suitable for making fluid connection between irrigation storage and the irrigation port, and this attractant inner chamber is suitable for making fluid connection between attractant storage and the attractant port.Pumping installations can be suitable for making the flush fluid in the irrigation storage to discharge through the irrigation inner chamber and from the irrigation port.Can comprise interface zone, this interface zone comprises at least one nonfluid stream assembly and at least one air-flow assembly.

In some embodiments, this barrier device can be positioned at shell and/or be positioned at the attractant storage.This barrier device can comprise at least a in hydrophobic filter, foam, sponge, no filter structure (filterless configuration), crisscross passage (a maze of channels) and the Cotton Gossypii.

In some embodiments, this shell can comprise flexible portion, and this flexible portion is suitable for extruding or pushing, so that exert pressure and flush fluid is discharged from the irrigation storage to the irrigation storage directly or indirectly.

In some embodiments, can comprise that being used for test attracts the fluidic diagnostic equipment.

In some embodiments, can comprise the main body that is suitable for being incorporated into releasedly shell, this main body comprises and being suitable for fluid suction attractant port, and passes through the pumping installations in the attractant inner chamber suction attractant storage.This main body can further comprise the controller that is suitable for controlling I & A one or both of.This main body also can comprise power source.

This main body also can comprise interface zone, and this interface zone is suitable for this main body is incorporated into shell.This at least one nonfluid stream assembly can comprise corrugated tube (bellow), thereby puts on flush fluid is discharged from the flushing storage to be used in the future the power of autonomous agent.This at least one air-flow assembly can comprise lets gas flow into the path the main body from attracting storage.

Another aspect of the present invention provides and has been used to send and removes fluidic hand-held device.This hand-held device comprises removable and interchangeable head.This head comprises shell, be arranged in the irrigation storage that is suitable for holding flush fluid of shell, be positioned at shell be suitable for hold attract fluidic attractant storage, be suitable for attraction fluid is retained in the attractant storage and lets gas from the effusive barrier device of attractant storage, nozzle that at least one stretches out from shell and be suitable for being incorporated into releasedly the main body on the shell; This main body comprises and being suitable for the pumping installations in the fluid suction attractant storage and the pumping installations and the interface zone that are suitable for flush fluid is discharged from the irrigation storage; This interface zone comprises at least one nonfluid stream assembly and at least one air-flow assembly, and this interface zone is incorporated into this main body with this head.

In some embodiments; This nozzle can comprise irrigation inner chamber and attractant inner chamber; This irrigation inner chamber is suitable for making fluid connection between irrigation storage and the irrigation port, and this attractant inner chamber is suitable for making fluid connection between attractant storage and the attractant port.

In some embodiments; This main body can comprise and being suitable for fluid suction attractant port and through the pumping installations in the attractant inner chamber suction attractant storage, and the pumping installations that is suitable for making the flush fluid in the irrigation storage to pass through the irrigation inner chamber and discharge from the irrigation port.

In some embodiments; This nozzle can be suitable for the patchhole normal sensation in the mouth and limit the sealing member between nozzle and the aperture; This device is suitable for making flush fluid to enter out and get in this aperture through irrigation lumen and irrigation ports, and this device is suitable for making fluid through attracting port and attracting the storage from the aperture suction through the attraction inner chamber.

In some embodiments; This interface zone can comprise the sealing member between head and the main body; The sealing part is suitable for the power that is applied on the main body is transferred to head, and the sealing part is suitable for letting the suction pressure of autonomous agent that gas is extracted out the main body of going forward side by side from attracting storage.

In some embodiments, the power that is applied on the main body can comprise the power that is applied on the control device, and the power that is applied on the control device is transferred in the flushing storage in the head through sealing member.Thereby the power on the control device of being applied to can be suitable for activating suction pressure extracts gas the main body of going forward side by side out from attracting storage.

Another aspect of the invention provides sends and/or removes fluidic method.This method can comprise the step that hand-held device is provided, and this device comprises removable and interchangeable head.This head can comprise shell, be positioned at the irrigation storage that is suitable for holding flush fluid of shell, be positioned at shell be suitable for hold attract fluidic attractant storage and nozzle that at least one stretches out from shell.

This device can further comprise and be suitable for institute is attracted fluid to be retained in the attractant storage and lets gas from the effusive barrier device of attractant storage; Control the fluidic control device of sending and/or removing; Be suitable for being incorporated into releasedly the main body of shell, this main body comprises the pumping installations that is suitable for the pumping installations in the fluid suction attractant storage and is suitable for making flush fluid to discharge from the irrigation storage; And the interface zone between head and main body, this interface zone comprises at least one nonfluid stream assembly and at least one air flow components.

Thereby this step may further include nozzle is arranged on and makes nozzle with respect to this aperture sealing in patient's the aperture; Utilize control device that flush fluid is escaped and enter this aperture through nozzle from the flushing storage, thereby and/or utilize control device activation suction pressure that fluid is attracted the storage from the aperture through nozzle extraction and entering.

In some embodiments; This method may further include utilizes control device that flush fluid is discharged; Thereby and utilize same control device activation suction pressure that flush fluid is escaped and enter this aperture from the flushing storage through nozzle, and fluid is extracted out and got into the attraction storage from this aperture through nozzle.

In some embodiments; Thereby this method can also comprise that the first to control device applies first power flush fluid is escaped and enter the aperture from the flushing storage through nozzle, thereby and/or applies second power to the second portion of control device and activate suction pressure and attract the storage so that fluid is extracted out and got into from the aperture through nozzle.

In some embodiments, this method also can comprise be provided for testing attract fluid and hand-held device that attraction fluid is tested in the diagnostic equipment.

In another aspect of the invention, the device test kit can be used as the I & A system to be provided.This test kit can comprise shell, be positioned at shell be suitable for hold the irrigation storage of flush fluid and be positioned at shell be suitable for hold attract fluidic attractant storage, nozzle that at least one stretches out from shell; This nozzle comprises irrigation inner chamber and attractant inner chamber; This irrigation inner chamber is suitable for making fluid connection between irrigation storage and the irrigation port, and this attractant inner chamber is suitable for making fluid connection between attractant storage and the attractant port.This test kit can also comprise the main body that is suitable for being incorporated into releasedly shell and be suitable for extracting the control device that institute attracts fluidic pumping installations and controls the pumping installations that is suitable for making the flush fluid discharge with controlling; This main body comprises and being suitable in the fluid suction attractant port; And through the pumping installations in the attractant inner chamber suction attractant storage be suitable for making flush fluid from the irrigation storage and the pumping installations of discharging from irrigation ports.This test kit can also comprise the operation of describing this I & A system and the operation instruction of use; This explanation comprises following operation: nozzle is arranged in the aperture so that nozzle seals with respect to the aperture; Utilize control device that flush fluid is escaped and enter the aperture from the flushing storage through nozzle, thereby and utilize control device to activate suction pressure fluid is passed through nozzle from aperture suction attraction storage.

In some embodiments; This explanation may further include and utilizes control device that flush fluid is escaped and enter the aperture from the flushing storage through nozzle, thereby and utilizes same control device activation suction pressure from this aperture through nozzle fluid extraction and entering to be attracted the storage.

In some embodiments; This description may further include utilizes control device; Thereby apply first power flush fluid is escaped and enter the aperture through nozzle from the flushing storage, thereby and utilize this control device to apply second power once more and activate suction pressure and attract the storage so that fluid is extracted out and got into from this aperture through nozzle to the second portion of control device to the first of control device.

One aspect of the present invention provides a kind of handheld test device.This device comprises hand-held housing; This shell comprises the head and the base portion that are suitable for being bonded to each other releasedly at interface zone, be arranged in shell be suitable for hold attract fluidic attractant storage, be positioned at shell be suitable for the pumping installations of fluid suction attractant storage and be positioned at shell be used for test institute attract the fluidic diagnostic equipment, this diagnostic equipment to be suitable for providing to test attract fluidic indication as a result.

One aspect of the present invention provides the system that is used for body orifice is carried out I & A.This system can comprise head and main body; This head is suitable in the flushing storage, holding the flush fluid of scheduled volume; And this head comprise be suitable for holding scheduled volume attract fluidic attraction storage, this main body to be incorporated into head releasedly and comprise the pumping installations in the fluid suction attractant storage, this system specialization the capacity of about 200cc to about 400cc; Have can be portable and operationally be held in size and the structure in the user hands; And it is about 5 that this system is suitable for producing, and 000cc/min is to about 20, the introducing fluid volume of 000cc/min.

In some embodiments, it is about 5 that this system can further be suitable for producing, and 000cc/min is to about 20, and the introducing fluid volume of 000cc/min continues about 1 second to about 30 minutes time.

In some embodiments, this system can further be suitable for producing to about 15 watts power consumption with about 5 watts about 5, and 000cc/min is to about 20, the introducing fluid volume of 000cc/min.Power source can comprise the capacity of about 100mAh to about 1000mAh.

One aspect of the present invention provides and has been used for system that the aperture is washed and/or attracted.This system comprises washing capacity, attracts function and customer controller.

This washing capacity comprises flushing ability and flushing storage, and this flushing storage is suitable for holding flush fluid, and this flushing ability is imported startup by the user in the washing capacity, and this flushing ability acts on the flushing storage so that flush fluid is escaped and enter the aperture from making the flushing storage.

This attraction function comprises suction pressure and attracts storage, and this attractions storage is suitable for catching institute and attracts fluid, this attraction storage to be suitable for institute's attraction fluid is retained in the attraction storage and makes gas attract the storage outflow from this.

This customer controller can be suitable for providing to washing capacity and the control function one of at least that attracts in the function, and this washing capacity is carried out off and on or carried out simultaneously with the running that attracts function.

The running of this washing capacity can attract the running of function to have no interaction with this, and the running of this attraction function can have no interaction with the running of this washing capacity.

State in other features and advantages of the present invention description and the accompanying drawing below.

Description of drawings

Fig. 1 is the cross section anatomical structure side view of head, shows nasal cavity and hole chamber.

Fig. 2 is facial anatomical structure front view, shows four paranasal sinusess that are communicated with nasal cavity.

Fig. 3 is a kind of perspective view of modification that is suitable for the device of I & A.

Fig. 4 is the side view of a kind of modification of I & A device shown in Figure 3.

Fig. 5 A is a head cross section anatomical structure side view shown in Figure 1, shows the modification that the I & A device of I & A function is provided as shown in Figure 3, is keeping being connected with joint when the nostril seals or the ability of deflection with this device.

Fig. 5 B provides the flexible tip of the device that seals with the nostril and extends through this flexible tip and gets into nasal cavity, the amplification anatomical structure internal view of the modification of the I & A passage of the ability of I & A simultaneously is provided.

Fig. 6 is the exploded view of a kind of modification of the device that is suitable for I & A as shown in Figure 3.

Fig. 7 A is a kind of plane graph of modification of the test kit of packing I & A device as shown in Figure 3 and operation instruction.

Fig. 7 B is the plane graph that test kit is replaced in the confession similar with test kit shown in Fig. 7 A, extra irrigation and operation instruction that this has supplied the replacement kit package.

Fig. 8 A is a kind of perspective view of modification that can be included in head and the sealing member between the main body of I & A device.

Fig. 8 B is the perspective view of a kind of modification of the I & A device that removed from apparatus main body of head, shows the sealing member shown in Fig. 8 A that is arranged on the main body, and shows the characteristic of the present invention that comprises at least a portion interface zone.

Fig. 8 C is similar with Fig. 8 B, but sealing member and main body are decomposing the perspective view shown in the structure, shows with the interaction of sealing member and comprises the characteristic of the present invention of at least a portion interface zone.

Fig. 9 is the side view of a kind of modification of the I & A device in the user hands.

Figure 10 A is the side view of a kind of modification of I & A device, shows the head that removes from this apparatus main body, and shows the characteristic of the present invention that comprises at least a portion interface zone.

Figure 10 B is the rearview of head and the front view of base portion, shows sealing member and the characteristic that comprises the head of at least a portion interface zone.

Figure 11 A is the exploded view of a kind of modification of I & A device head, shows to comprise flushing storage and the head that attracts storage.

Figure 11 B is the enlarged drawing of flexible tip close end, shows irrigation channel and attracts passage.

Figure 12 is another exploded view of a kind of modification of the I & A device head shown in Figure 11 A.

Figure 13 A and Figure 13 B are the rearview and the side views of a kind of modification of I & A device head, show the head that comprises barrier device, and this barrier device comprises blade and/or deflection plate (baffle).

Figure 14 is the side view of a kind of modification of I & A device head, comprises that flexible region can be extruded to discharge flush fluid this head thereby show this head.

Figure 15 A is the perspective view of a kind of modification of I & A device head, show this head comprise removable or replaceable, perhaps reusable or disposable flushing and/or attract storage.

Figure 15 B shows a kind of replaceable modification of I & A device head, and shows the side view of the part perspective (partial phantom) of the flexible tip of integrating with the housing of this head and/or head.

Figure 15 C is the perspective view of a kind of replaceable modification of I & A device head; Show head and comprise shape and the structure that supplies replacement; And be removable or interchangeable, perhaps reusable or disposable, this head has flushing and/or attracts storage.

Figure 15 D is the perspective view of a kind of replaceable modification of I & A device head; Show head and comprise confession replacement shape and structure; Comprise the structure that head and flexible tip combine; And be removable or interchangeable, perhaps reusable or disposable, this head has flushing and/or attracts storage.

Figure 16 is the side view of flexible tip modification and the block that removes.

Figure 17 is the front view of a kind of modification of flexible tip shown in figure 16.

Figure 18 is the perspective view of a kind of modification of flexible tip, shows the flexible tip that has recessed and eccentric I & A port.

Figure 19 is the side view in cross section of a kind of modification of I & A device head; Show and comprise flushing storage and the head that attracts storage; And I & A circulation road; This structure is suitable for providing complete isolating I & A fluid, and the I & A through single tip or nozzle can be carried out simultaneously.

Figure 20 is the side view in cross section of a kind of modification of I & A device head shown in figure 19, shows the flexible tip that comprises a plurality of attractions and irrigation ports.

Figure 21 is the side view of a kind of modification of I & A device head, shows the whole bag of tricks of filling this I & A device with irrigation.

Figure 22 A to Figure 22 C is the sketch map of cut-away section of (multiple) modification that the I & A device head of the replacement structure that comprises the diagnostic equipment is shown.

Figure 23 is the perspective view that has the cut-away section of I & A device modification, and the power source that is carried in this device base portion is shown.

Figure 24 is a kind of perspective view of modification of the charger of the power source that is suitable for the I & A device that is equipped with rechargeable power source is recharged.

Figure 25 is the perspective view of a kind of modification of I & A device head, shows one or both the modification of controller that is suitable for letting the user control attracting in function and the washing capacity.

Figure 26 to Figure 29 shows the modification of the method for using I & A device modification.

Figure 30 is the exploded view of the modification of the pump that is suitable for using with a kind of modification of I & A device and motor.

Figure 31 is the cutaway view of pump shown in figure 30.

Figure 32 is pump shown in figure 30 and a kind of exploded view of replacing modification of motor confession.

Figure 33 is the perspective view of a kind of modification of the I & A device head similar with head shown in Figure 25, shows a kind of modification of the controller that is suitable for letting the user control washing capacity.

Figure 34 A is the side exploded view of the partial cross section of I & A device head shown in Figure 33, show to be suitable for letting the user directly or indirectly control the controller modification of washing capacity, and show comprise at least a portion interface zone characteristic of the present invention.

Figure 34 B is the perspective view of the I & A device head shown in Figure 34 A, shows the modification of the controller that is suitable for the power from the customer controller of washing capacity is shifted.

Figure 35 A and Figure 35 B are the schematic diagrams of modification with I & A device of various structures.

Figure 36 is the part perspective diagram (see-throughview) of a kind of modification of I & A device.

Figure 37 is a kind of cutaway view of modification of the attraction assembly of I & A device.

Figure 38 is the cutaway view of a kind of modification of I & A device.

Figure 39 is the phantom and the part schematic diagram of a kind of modification of I & A device.

Figure 40 is the phantom and the part schematic diagram of a kind of modification of I & A device.

Figure 41 is phantom, partially transparent view and the part schematic diagram of a kind of modification of I & A device.

Figure 42 shows the modification of the method for using I & A device modification.

Figure 43 is the schematic diagram that has the I & A device modification of remote component (remote control module, remote component).

Figure 44 is the perspective view of a kind of modification of I & A device, shows the device that comprises twin-jet nozzle.

Figure 45 is the anatomical structure figure of the portion on the upper side in patient's nasal cavity and cross section, hole chamber, shows to comprise two tips, wash from a tip through nasal cavity and hole chamber, and the use of a kind of modification of the I & A device that attracts from another tip.

Figure 46 is the side view of a kind of modification of I & A device, shows to comprise and be used to produce and the trigger of sustained release pressure or the device of handle.

Figure 47 is the side view of a kind of modification of I & A device, shows to comprise and be used to store the device that is used to produce with the jar of the Compressed Gas of sustained release pressure.

Figure 48 A to Figure 48 B is the side view of a kind of modification of I & A device, shows to comprise the device that is used to produce with the corrugated tube of sustained release pressure.

The specific embodiment

Though in detail and clearly the disclosure of invention has been described so that make those skilled in the art can embodiment of the present invention, the only exemplary illustration the present invention of the disclosed entity embodiment of this paper, the present invention can implement by other concrete structures.Though preferred implementation has been described about being used to alleviate the application at the place, nostril in nasal cavity and hole chamber, is not deviating under the situation of the present invention and can change details, the present invention is defined by the claims.Should also be understood that the apparatus and method that comprise characteristic of the present invention also are applicable in one or both all useful any positions or cavity in the I & A.

Handle so that certain position or cavity are washed and/or during the I & A device that attracts when mentioning by doctor or operator, term " near-end " and " far-end " can be used to describe this device in use with respect to operator's relation or orientation.So; Term " near-end " will be used to describe relation that this device is provided with towards the operator in use or orientation (promptly; Handle or base end at this device); And term " far-end " will be used to describe position or the orientation (that is, at the other end of this device, like head and nozzle or conduit) that this device is provided with away from the operator in use.

When term attract with attractant as element (for example, attracting storage 40 and attractant storage 40), and/or during the functional descriptions speech, they can exchange use in this article.When term flushing was used as the descriptor of element and/or function with irrigation, they can exchange use in this article.When term atomizing was used as the descriptor of element and/or function with atomizing, they can exchange use in this article.

Any element that this paper is described as singulative all can be plural form (that is any element that, is described as " (a kind of) " can be for more than one).Characteristic or element that any kind (species) element in total type (genus) element all can have this total any other type element of apoplexy due to endogenous wind.Describedly be used for embodiment of the present invention and aspect of the present invention variation thereof, element or close set piece installing and method and their element and each other can any way combine and revise.

I. nasal anatomic structure

The relevant symptoms that these apparatus and method are suitable for treating nasal congestion and congestion of nasal sinus and are caused by multiple possible reason very much.For this reason, this apparatus and method will be described under this background.It is also understood that disclosed apparatus and method are applicable to other symptoms at other positions of treatment health, these positions may not be relevant with nose.

Nose is used as the opening of air flue in respiratory system.As from Fig. 1 and Fig. 2, finding out, the nose support appears at the first half of nose, and the major part of Lower Half comprises the wing of nose, is cartilage.Part bone and cartilage nasal septum are divided into two nasal cavities with the chamber of nose.There are four paranasal sinusess to be communicated with: maxillary sinus, sieve hole, sinus frontalis and sphenoid sinus with nasal cavity.

The zone of the inner vibrissa growth of nasal cavity is called nasal vestibule.Nasal cavity position far away is a concha nasalis.Concha nasalis is the tabular outthrust on the nasal wall.Mucous gland is arranged in these foot---on the concha nasalis inferior.Be cilium on the concha nasalis surface, fluctuating is moved mucus outward nostril thereby they constantly fluctuate.The topmost of nasal cavity is the residing zone of organum olfactorium.

The function of nasal cavity comprise to inhaled air clean, heating and moistening.Mainly through middle nasal meatus's (on concha nasalis inferior), in the middle nasal meatus, 60～70% dust is removed inhaled air, and this air is transformed into 25～35 degrees centigrade temperature and 35～80% humidity.

Nasal cavity is lined with mucosa.The olfactory sensation receptor cell is arranged in superior nasal concha, and many olfactory sensation receptor cells are arranged in surperficial mucosa.Be dissolved in the mucus and stimulate cilium as the molecule in abnormal smells from the patient source, cilium changes into the signal of telecommunication with them.This signal passes olfactory bulb, arrives the olfactory center of brain neopallium, causes the sensory perception of abnormal smells from the patient.

Because paranasal sinuses links to each other through the hole that leads to them with nasal cavity, infection can be propagated from nasal cavity, produces inflammation and nasal sinuses mucosa swelling (sinusitis) and local pain thus.Sometimes several nasal sinuses inflammation (pansinusitis), and the swelling meeting of mucosa blocking-up nasal sinuses leads to one or more openings of nasal cavity.

It is normal having some mucus in nose and the throat, but the increase of mucous amount just may hinder comfortable breathing, can be through attempting removing mucus to the expectorant in nose air blowing or the expectoration throat.

Under the situation of bacterial infection, antibacterial is trapped in the nasal sinuses that has stopped up, in moist and nutritious environment, breeds.Antibiotic can be used to treat the superinfection under these situation fruitfully, but generally inoperative to initial reason.

II. flushing and/or suction device general introduction

Fig. 3 and Fig. 4 show and are used for cleaning device 2 or system that biological tissue or fluid are washed and/or attract.Device 2 can be used in the body orifice or on it, and this body orifice comprises cavity or inner chamber or blood vessel or pleat, like nasal vestibule, nasal cavity, mouth and/or throat, ear, eyes, skin fold, umbilicus, wound or their combination.Device 2 can be inserted in the nature body orifice; Comprise cavity or inner chamber or blood vessel or pleat; Like nasal cavity, mouth-comprise getting into throat, esophagus, stomach, lung, auditory meatus, eyes, umbilicus, rectum, urethra, vagina; Or fatty pleat or fatty pleat, wound, operating theater instruments (like the operation port), or their combination, all these is a limiting examples.

For example, device 2 can be configured to, and for example carries out individually, alternately, sequentially or simultaneously that snuffing is drawn and/or nasal irrigation (Fig. 5).Attraction can comprise suction,, produces vacuum or negative pressure via for example pump and/or Venturi effect that is.Device 2 can be configured to I & A, once carries out one, and/or executed in parallel.The flushing that device 2 can have the vacuum and the manual activation of automatic driving, this two can operate simultaneously.Device 2 can have the vacuum of automatic driving and the flushing of self actuating, this two can operate simultaneously.The flushing that device 2 can have the vacuum and the manual activation of manual actuation, this two can operate simultaneously.Device 2 can have the vacuum of manual actuation and the flushing of self actuating, this two can operate simultaneously.Install 2 and already can be configured to, comprise flush fluid and attraction fluid are separated washing capacity and attraction functional separation.Flushing activates and can separate control with attracting actuating.Irrigant stream can be separated fully with attractant stream or part is separated.

Device 2 comprises the technical characterictic of various expectations.As as can be seen from Figure 6, device 2 can comprise the main body 4 that is incorporated into removedly on the head 14.Main body 4 and head 14 can be disposable, reusable, interchangeable and/or be used up and can abandon.Main body 4 and head 14 can be totally but disinfectant form not, or offer the user through the sterilization form.Main body 4 comprises shell (case) 5, and dynamic source 6, pump 8, motor 9 and customer controller 10 are shown in this shell and/or on it.Thereby pump 8 and/or motor 9 can provide high sustained flow rates with low max vac pressure through optimizing.Shown head 14 comprises housing 16, flexible tip 18, block 20, the diagnostic equipment 22, barrier device 24, irrigation storage 30 and attractant storage 40.With irrigation storage 30 and attractant storage 40 be combined in use up can abandon and/or reusable head 14 in help to isolate the fluid that might be polluted.Flush fluid 32 can be contained in the head 14, and can never get into main body 4, maybe can be contained in main body 4 and the head 14, or only be contained in the main body 4.Barrier 24 can stop contaminated attractive material 42, and promptly fluid gets in the main body 4.The technical characterictic of each expectation will be described in detail belows.

Device 2 can be constructed to attract under the situation of no flow restriction or minimum flow restriction with total power, for example, and up to about 20,000cc/min (1,220in ³/ min), or be 15 more accurately, 000cc/min (915in ³/ min), or be 10 more accurately, 000cc/min (610in ³/ min), or be 5 more accurately, 000cc/min (305in ³/ min), perhaps more or less air for example continues nearly 1 second or 1 minute or half an hour or 1 hour or 2 hours, or longer or shorter continuous service time.

Installing 2 shells is constructed to produce under the situation of no flow restriction or minimum flow restriction with total power; For example up to about 200mm Hg (3.86psi), or be about 120mm Hg (2.32psi) more accurately, or be about 80mm Hg (1.55psi) more accurately; Or be about 50mmHg (0.966psi) more accurately; Perhaps greater or lesser attraction swabbing pressure continues for example to reach half an hour or 1 hour or 2 hours, perhaps longer or shorter continuous service time.Device 2 can comprise that thereby the vacuum pressure limiting valve 128 as safety component is restricted to for example 100mmHg with obtainable vacuum.

Device 2 is constructed to wash up to about 3cc/min (0.183in under the situation of no flow restriction or minimum flow restriction with the total power that is used for flushing automatically ³/ be about 1.5cc/min (0.092in min.) or more accurately ³/ be about 0.5cc/min (0.031in min) or more accurately ³/ min.), or more or less irrigation 32.

Device 2 is configured to manually flushing with each direct or indirect depressing or activating; For example; Every stroke of piston or plunger or syringe or pump 11 can wash up to about 1.0cc or more accurately for 0.5cc or be 0.25cc, or greater or lesser volume more accurately.

Device 2 can be constructed to be configured to use about 15 watts or be about 10 watts or be about 5 watts, or greater or lesser watt more accurately more accurately with total power.The amount of used watt generally depends on the vacuum draw amount, that is, during attracting to the limit amount of air flow.

Device 2 can be constructed to be configured to produce about 40db or be about 30db more accurately or be about 20db, perhaps greater or lesser noise level more accurately with total power.The amount of the noise level that is produced generally depends on the vacuum draw amount, that is, during attracting to the limit amount of air flow.

Device 2 can be constructed to portable.For example, device 2 can not attach on any external device (ED) (for example, be installed in wall or ground outlet, or power source, pressure source, irrigation source, or attractant storage).Device 2 can be constructed to be connected in for example wall type vacuum pump or portable vacuum pump.

Device 2 can be constructed to the handheld apparatus of ergonomic.For example, device 2 can weigh about 5.0kg (11lbs.), more accurately for about 2.0kg (4.4lbs.), more accurately for about 1.0kg (2.2lbs.), for example about 0.45kg (1.0lbs.), perhaps more weigh or lighter.

Device 2 maximum total height can for, for example, less than about 40cm (16in.), more accurately for less than about 30cm (12in.), also be less than about 25cm (10in.) more accurately, also can comprise about 21.5cm (8.5in.) or greater or lesser height.Device 2 total width can for, for example, less than about 41cm (16in.), more accurately for less than about 30cm (12in.), also more accurately for less than about 25cm (10in.), also can comprise about 5cm (2in.), perhaps greater or lesser width.Device 2 maximum overall diameter can for, for example, less than about 20cm (8in.), more accurately for less than about 15cm (6in.), also more accurately for less than about 10cm (4in.), also can comprise about 9cm (3.5in.), perhaps greater or lesser diameter.

Device 2 can have total measurement (volume).For example, the total measurement (volume) of device 2 can be about 400cc (24.5in ³), more accurately for about 300cc (18.3in ³), and more accurately for about 200cc (12.2in ³) or greater or lesser.

Device 2 can be used for delivery of fluids, for example, and water, saline, medicine, medical herbs, vaccine, diagnostic agent, antiseptic, powder and any combination.Device 2 can be used for delivering a fluid to above-mentioned any one body cavity or body orifice zone.

III. system's test kit

Shown in Fig. 7 A, the cleaning device of describing in the preceding text 2 can merge and be used for one or more multi-part function test kits 50.Should be understood that what each assembly may not be shown to scale.

Test kit 50 can be taked various ways.In the illustrated embodiment, test kit 50 comprises the individual packaging 51,52,53 and 54 that is assembled together.In this packing each or one or more can comprising totally or disinfectant packing or bag type assembly.One or more in this packing can comprise the inner tray or the clamp of for example being processed by die cut paper sheet, plastic plate or thermoforming plastic material (card) that are used to hold inclusion.Test kit 50 also preferably includes the explanation or the description 58 of the inclusion carry out desired program of using this packing.The program that the inclusion that uses test kit 50 shown in Fig. 7 A carries out will be described below in more detail.

Operation instruction 58 certainly changes.Operation instruction 58 can physically be present among one or more in this packing, but also can provide separately.Operation instruction 58 can be included in the independent description handbook, perhaps be video or recording form.Operation instruction 58 also can obtain through internet web page.

A. parts are packed

The layout of this packing and inclusion are to change.For example, shown in Fig. 7 A, test kit 50 comprises packing 51,52,53 and 54, and description 58.Two critical pieces that packing 51 and 52 provides like described cleaning device 2 wherein, wherein main body 4 is in packing 51, and head 14 is in packing 52.Remaining packing 53 and 54 can comprise maybe can be not included in, and can provide with install 2 is connected use (one or more) accessory, for example, pack the container 56 of the flush fluid in 53 and pack the filled device base portion 62 in 54.In packing 52, the flush fluid 32 of can packing in advance in the head 14 of device 2.

The parts that test kit 60 (Fig. 7 B) can be used as test kit 50 are included, and maybe can be independent test kits.Test kit 60 can comprise the irrigation container 56 of predetermined quantity, and for example, shown test kit 60 comprises 10 irrigation containers 56, but can comprise more or less irrigation container.Also operation instruction 58 can be provided, thus guides user operative installations 2 and/or how to use irrigation container 56 to recharge irrigation 32 for irrigation storage 30 how.The replacement dress of flexible tip 18 also can be provided in the test kit.

The other configuration that should be understood that test kit also is possible.For example, a test kit or a plurality of test kit can comprise the other parts that attract the fluidic diagnostic equipment to being suitable for testing.In addition, a test kit or a plurality of test kit can comprise the modification of device 2, comprise non-rechargeabel device, non-battery-operated type device and/or hand gear, and these are limiting examples.

IV. the I & A technical characterictic of expecting

Thereby cleaning device 2 can combine various technical characterictics to strengthen its versatility, comprises the I & A function.

A. hand-held form

1. main body

Technical characterictic according to an expectation; Device 2 (for example can comprise the main body 4 that is incorporated into the reusable of head 14 removedly and/or uses up the ergonomic that can abandon; Handle), device 2 is suitable for user with a hands (left hand or the right hand) use and control like a cork.

As as can be seen from Figure 6, can pack in the main body 4 can fill or non-refillable power source 6 again, like battery and/or compressed gas source.Main body 4 also can be connected on the external power supply, for example, connects via power source line (not shown).Main body 4 can be constructed to be connected to vacuum source, for example, and wall type vacuum pump or portable vacuum pump.Main body 4 can have and is used to the fluid control systems that washes and/or attract.This fluid control systems can have one or more pumps 8 and 11.This fluid control systems can have CD-ROM drive motor 9.Arbitrary pumping installations 8 and/or 11 all can manual operation (for example, extruding, pushing, and/or trigger operation), or operation automatically (for example, AC or DC are electronic, Compressed Gas, energy storage, venturi port).As limiting examples, but arbitrary pump 8 and/or 11 can be maybe to have syringe, flexibility or compression assemblies, piston pump, aerator (blower), turbine, fan, linear pump, wheel rotor pump, centrifugal pump, reciprocating pump, membrane pump or their combination.Motor 9 can or be independent parts for a part of of pump.

The shell 5 and the inside of main body 4 can be by plastics, and for example ABS, Merlon or their combination are processed.The shell 5 of main body 4 can for example be processed through injection moulding half module and assembling through injection moulding with inside.As finding out among Fig. 6, shown shell 5 comprises two half modules, can use more or less molding part (piece) but should understand.

Main body 4 (and/or head 14) the inside of main body 4 (and/or head 14) or outside on can have draw-barring or sealing member 66.As the parts of interface zone 13, sealing member 66 can be constructed to make not leakage current body ground combination between main body 4 and the head 14.As from Fig. 8 A～Fig. 8 C, finding out, sealing member 66 can comprise corrugated tube 68 and path 70.Corrugated tube 68 makes not leakage current body ground sealing between pump 11 and the irrigation storage 30 in the head 14 in the base portion.Path 70 makes fluid, that is, air flows to the pump 8 the base portion 4 from attractant storage 40 through barrier 24.Sealing member 66 can be suitable for making I & A system and function to separate.Sealing member 66 can be suitable for making the flushing ability that is applied on the base portion 4 to transfer to head, and the sealing part can be suitable for making suction pressure from base portion 4 with gas from attract storage 40 suction base portions 4.

Can find out that from Fig. 8 C the parts 188 of pump 11 can be constructed to apply direct or indirect power to corrugated tube 68.Thereby this power can be transferred to head 14 and make irrigation ejection from flushing storage 30 then.

As can be seen from Figure 9, main body 4 is held in the hands with can being constructed to ergonomic.Main body 4 can have the profile that cooperates with palm 74 and finger 76 when being held.Main body 4 can comprise gripping fills up 78.This grips pad 78 can comprise soft rubber, metal, flexible plastic or other known materials, and can be attached on the main body 4 and/or form whole with main body 4.Gripping pad 78 can be slick, and they can have bulge (ridge) or texture, or their combination.Grip pad and 78 can be installed in around the main body 4 to ergonomic, and grip and fill up 78 and can be constructed to be installed in user between the operating period (for example, the palm of user) whole in the zone that main body 4 is exerted pressure naturally or some are regional.

Main body 4 (and/or head 14) can have shades of colour, and can be transparent, translucent and/or opaque material.Main body 4 (and/or head 14) also can combine the indication form such as lamp, for example is used to operate purpose and/or user and/or patient's amusement.Main body 4 (and/or head 14) can combine " key (key) " or co-operating member (fitment element) 15, so that the aligned head 14 of needs is aimed at main body 4.Adapter 12 (following) can provide this characteristic.Main body 4 can with head 14 communications (connection), and head 14 can with main body 4 communications (connection), for example, telecommunications (connection) between main body 4 and the head 14 for example is used for diagnosis, state or indication purpose.

Can carry out damping to installing 2 any vibration or vibration (for example, owing to cause) such as movable parts such as pump, motor, reciprocating type solenoid, piezoelectric transducers.Can use antivibrator, movable part is installed on main body 4 or the head 14 like soft rubber washer.For example, in discharging conduit 166, use current limiting plate, can suppress too high pressure and pump and discharge.Can increase wall (for example, shell 5 and the housing 16) thickness of device 2, and it can be processed by stratiform and/or laminated material.Can otherwise make the wall sound insulation of device 2.Can make the movable part dynamic equilibrium in the device 2, for example,, and/or install 2 and can have effective noise elimination function so that be zero in all holding power sums of any given instant.Motor (for example, in the pump or be incorporated into the motor on the pump) can have (counterweight) effect that contends with.A plurality of motors can be constructed to resist power.

(in-body) power source 6 (being described below) in the irrigation storage 30 of filling and/or attractant storage 40 and main body; The device 2 about 5.0kg (11lbs.) that can weigh; Be about 2.0kg (4.4lbs.) more accurately; Be about 1.0kg (2.2lbs.), for example about 0.45kg (1.0lbs.), perhaps greater or lesser weight more accurately.Storage 30 and/or attractant storage 40 can be translucent and/or transparent, thereby the user can be determined when change/recharge irrigation 32 and/or when emptying attractant 42, and/or the when cleannes and/or the operation of testing fixture 2.

2. head

According to the technical characterictic of an expectation, head 14 can be attached on the main body 4 (referring to Figure 10 A and Figure 10 B) removedly or form whole with main body 4.Head 14 can be with respect to 4 one-tenth different angle settings of main body, and can be suitable for respect to main body 4 joint connection freely and/or deflection and/or pivot.Head 14 with can have elasticity (compliant) and flexibility being connected of main body 4 so that head 14 can pivot and translations (translate) around head 14 (this statement only from purpose for example, has multiple mechanical solution).Head 14 can attach to main body 4 removedly through adapter 12 (one or more).Can head 14 be pressed on the main body 4, till adapter 12 rattles away head 14 clicks to get into the appropriate location.As limiting examples, adapter 12 can be screw, buckle (snap), be pressed into matching connector or their combination.

Flushing and/or attraction system, method and function can have or comprise interface zone 13, and interface zone 13 is between main body 4 and head 14 and/or comprise the part of main body 4 and head 14.This interface zone can, for example, directly or indirectly pump is connected to storage, and/or vacuum pressure is connected to storage.Interface zone 13 can be suitable for making I & A system, method and function to separate.

Interface zone 13 can; For example; Comprise nonfluid stream district or (one or more) parts that power 180 wherein can be transferred; Like irrigation connector (plug) 28 and/or corrugated tube 68 and/or flushing hole 190, and interface zone 13 can for example comprise flow area or (one or more) parts that gas wherein can be transferred, like path 70 and/or attract hole 192.Interface zone 13 can, for example, head 14 can be removed from main body 4, thereby irrigation storage 30 and attractant storage 40 can be included in the head 14, so that eliminate main body 4 by any contaminated fluids contamination of heavy.Flushing and/or attract (one or more) part of function can be from the head to remove in 14, this flushing and/or attract the remainder of function can still be attached on the main body 4 or with main body 4 form whole, like what below will describe.Interface zone 13 also can make between head 14 and the main body 4 and can rotate and translation.

As from Figure 11 A～Figure 12, finding out, head 14 can comprise housing 16 and back 26.Flexible nozzle or conduit or most advanced and sophisticated 18 can be outstanding from the far-end of housing 16, and can comprise block 20, when device 2 does not use and/or is not used for diagnostic purpose, can be arranged on the flexible tip 18 block 20 or wherein or its top.Block 20 can be included in the outer breachable seal of packing, when using for the first time, tears the sealing part.Can be reset on the flexible tip 18 block 20 or wherein then.Shown in irrigation storage 30 with attract storage 40 in housing 16, and the two can be communicated with flexible tip 18 fluids.

In some embodiments, barrier device 24 can be arranged in head 14/ or the main body 4.In some embodiments, barrier device 24 can or be arranged in this groove 27 with groove 27 adjacent settings in the back 26.For example, barrier 24 can comprise filter, like hydrophobic filter, foam, sponge, or other materials, like the Cotton Gossypii of spherical or other anticipant characters, or any combination.

Barrier device 24 can have the shape that is used in head 14 and the back 26 with being suitable for optimum.Utilized the surf zone in the head 14 efficiently such as reniform shape; And thereby reduced the resistance that barrier device provides; But other linear and non-linear shape also are possible, like circle, square, triangle, deformable shape (deformable), deflection plate shape (baffled) or irregularly shaped (random).In some embodiments, barrier device 24 can comprise 10 micron filters, more accurately be 8 micron filters, and be about 5 micron filters, or other filter of greater or lesser level more accurately.Barrier device 24 can be constructed to allow gas (that is, air) to flow out through attractant storage 40, does not allow fluid (that is, the attractant fluid 42) to flow out through the attractant storage simultaneously.This barrier device has kept using up the head 14 that can abandon and the separation of the flush fluid 42 between the main body 4.

In some embodiments, barrier device 24 can comprise or comprise blade and/or deflection plate and/or the passage that is positioned at head 14 or main body 4, gets into the resistance (seeing Figure 13 A and Figure 13 B) of main body 14 thereby increase the fluid 42 that is attracted.This blade and/or deflection plate and/or passage also can with any combination in the previous materials.

Irrigation connector 28 can or be arranged in back 26 and/or the irrigation storage 30 with back 26 and/or the 30 adjacent settings of irrigation storage.As previously mentioned, head 14 (and/or main body 4) thus can comprise and make between main body 4 and the head 14 not by sealing member 66 leakage current body ground combines.Thereby thereby the corrugated tube 68 in the sealing member 66 makes the pump 11 in the base portion 4 irrigation fluid 32 discharged or ejection for irrigation storage 30 provides pressure 180 with connector 28 interactions.

The same as main body 4, the parts of above-mentioned head 14 also can be opaque, transparent and/or translucent, and also can have shades of colour.

In some embodiments, irrigation 32 can spray in every way.For example, in some embodiments, can utilize rack and pinion (rack-and-pinion) structure to make irrigation 32 ejections, mechanical advantage is provided.In other embodiments, can utilize direct interlock structure (directlinkage) to make irrigation 32 ejections.In other embodiments, thus thereby the part of head 14 can comprise that one or more deformable or flexible portions 72 make the user can push flushing storage 30 and make irrigation 32 discharge (seeing Figure 14).As directed, thereby can utilizing finger or 77 pairs of flexible portions 72 of thumb to exert pressure, the user produces the flushing pressure of expectation.

In some embodiments; When 30 emptyings of irrigation storage and/or attractant storage 40 are filled and/or otherwise need emptying or cleaning, can whole head 14 be removed from main body 4 and replace with the new head that accommodates more irrigation 32 in the irrigation storage 30 14.

Figure 15 A～Figure 15 D shows the replaceable embodiment of head 14.In the embodiment shown in Figure 15 A, head 14 comprises flushing storage box 30 and/or the attraction box 40 that is constructed to attach to removedly head 14.Head 14 and/or flushing storage box 30 and/or the port, uncinus (hook), latch (latch), peg (peg) or their combination that attract box 40 can have the same position that attaches to this head or box removedly.When not attached irrigation box 30, this box receptor (cartridge receptacle) can limit the space that the structure with irrigation box 30 is equal to basically.

Irrigation storage box 30 can have one or more port (not shown) that can engage with head 14.When irrigation storage box 30 is not placed in the head 14, the port on the irrigation storage box 30 can, for example closed or cover with adherent aluminium foil.For example; Head 14 can have and one or morely (for example is configured to pierce through irrigation storage box 30; Pass paper tinsel or sealing member) sticker (fang) or pipe; Can with the internal fluid communication of irrigation storage box 30, and can and/or from irrigation storage box 30, extract irrigation out to irrigation storage box 30 pressurization or decompression.

For example, when the first irrigation storage box 30 is empty, can the first irrigation storage box 30 be removed in 14 from the head, and replace with the second irrigation storage box 30.

In the embodiment of the head shown in Figure 15 B 14, flexible tip 18 can form whole with the housing 16 of head 14 and/or this head.As the part of housing, flexible region 17 can be incorporated into this tip 18, makes that most advanced and sophisticated 18 can be crooked.

In the embodiment of the head shown in Figure 15 C 14, this head comprises the flushing storage 30 and attraction storage 40 that is arranged side by side.This head comprises with box constructs more shapes similar factor (formfactor).

In the embodiment of the head shown in Figure 15 D 14, this head comprises the flushing storage 30 that is arranged in the attraction storage 40.Head 14 comprises the form factor that comprises monoblock type head 14 and flexible tip 18.

Irrigation storage 30 and/or attractant storage 40 can remove to be used for cleaning or replacement, and for example the form with above-mentioned box removes.As hereinafter in greater detail, attractant storage 40 can remove, and can also seal to be used for diagnostic purpose.The method that gets into attractant storage or box 40 can be provided, so that can get into this attractant fluid 42 to be used for test.

Head 14 and/or irrigation storage 30 and/or attractant storage 40 and/or install 2 passablely clean and/or in dish-washing machine, clean for example by hand.Main body 4 and/or to install 2 can be waterproof.

Head 14 and/or irrigation storage 30 and/or attractant storage 40 can clean; For example; In dish-washing machine, clean is that safe (dishwasher safe) (for example, can be at least about 50 degrees centigrade, or more accurately at least about 75 degrees centigrade; Stood under the perhaps higher or lower temperature about 15 minutes; And very significantly be not out of shape, go bad, or other damages, and in substantive rotten or other the substantive breaking-ups of appearance after water and typical dishwasher cleaning agent of same long term exposure).

A. flexible tip

Flexible tip 18 (that is, nozzle or conduit) can form wholely with head 14, perhaps can be removable and/or replaceable and/or uses up the parts that can abandon, and is as directed.Flexible tip 18 has desired size and is constructed to and waits to wash and/or the biological aperture that attracts or surface are adjacent or be inserted into wholly or in part in this biology aperture or the surface.For example, flexible tip 18 can be constructed to completely or partially fill in the nostril (sees Fig. 5 A), and its flexibility makes device 2 to move and/or the patient can move.Flexible tip 18 can have sharp cone distal, taper shape, mamillary, spherical, mushroom cap or waist columnar structure or their combination.Flexible tip 18 can comprise rods 80, and/or sealing device, as directed o ring 86.

In a kind of illustrative embodiments, the distal portions that Figure 16 shows flexible tip 18 can be constructed to comprise spherical or mushroom umbrella part 82.The distal portions of flexible tip 18 can be mamillary or waist shape.Flexible tip 18 can be bigger at the radius at the nearside place of far-end 84, thereby for example prevent that most advanced and sophisticated 18 too much insert in natural person's body orifice.

As from Fig. 5 B, finding out, tip 18 can be constructed to and wash and/or attract position (for example nostril) to form positive seal.Distal flexible part 82 and nostril form temporary sealing, make flushing (identifying with arrow 32) and attraction (identifying with arrow 42) respectively through irrigation channel 36 and 46 generations of attraction passage.

Most advanced and sophisticated 18 can be similar to ball-and-socket joint and/or be similar to the flushing of embedding tube (nested tube) and/or attract the position sealing.Flexible tip 18 can become to be symmetrical set rotatably around the longitudinal axis of head 14.Rotation orientation (rational alignment) can be separated with sealing function, for example, thereby makes the user obtain a degree of freedom greatly.

Flexible tip 18, and/or elastomeric material and/or medicine and/or lubricant processed and/or cover or be coated with to head 14 whole or some can by elastomeric material such as silicone rubber or foam.Flexible tip 18, and/or head 14 whole or some (that is the parts on patient basis) can be removable and/or interchangeable and/or use up and can abandon.Flexible tip 18 can be elastic, thereby for example can seal with difform nostril, thereby and can comprise that lubricant strengthens sealing.Flexible tip 18 can have enough rigidity so that under the negative pressure that attracts, can not deform.

Figure 17 and Figure 18 show far-end or the distal face 84 that flexible tip 18 comprises fluid passage (for example, any in the I & A passage or two).Shown distal face 84 comprises irrigation ports 34 and attracts port 44.Should be understood that to attract port 44 and irrigation ports 34 can be positioned on the outer surface of flexible tip 18, and/or attract port 44 and/or irrigation ports 34 can recessed flexible tip 18 in.It shall yet further be noted that in a kind of interchangeable embodiment flexible tip 18 can have one or more irrigation ports 34 and/or attract port 44.

As directed, irrigation ports 34 can be positioned at and attract port 44 position adjacent places (seeing Figure 17).Irrigation ports 34 can completely or partially be attracted port 44 and surround (seeing Figure 18).Attracting port 44 can be rinsed port 34 wholly or in part surrounds.

B. wash and the irrigation storage

As as can be seen from Figure 19, shown irrigation storage 30 is communicated with irrigation port 34 direct fluids via irrigation channel 36.In a kind of interchangeable embodiment, head 14 can have one or more irrigation ports 34 (seeing Figure 20).Irrigation ports 34 can be constructed to distribute or otherwise discharge flush fluid 32.Irrigation ports 34 can be constructed to distribute or otherwise discharge the flush fluid of atomised form, and this atomizing form is for example passed through flush fluid 32 (for example, being in liquid condition) is mixed with atomization gas, and/or flush fluid 32 is realized through nebulizer 38.Flush fluid 32 can be heated (for example, via power supply 6 electrical heating) thereby provide has body temperature or near the flush fluid 32 of body temperature, thereby brings extra comfort for the patient.

Shown flexible tip 18 comprises rods 80.Bar 80 (with flexible tip 18) can comprise irrigation channel 36.Irrigation channel 36 also can be the parts of irrigation storage 30, or independent parts, or any combination.The bar 80 of flexible tip can be arranged to be communicated with irrigation storage 30 fluids via irrigation storage port 35.

Irrigation channel 36 can have irrigation channel diameter 38.Irrigation channel diameter 38 can be the minimum diameter of irrigation channel 36.Irrigation channel diameter 38 can be less than about 1cm (0.4in.), more accurately less than about 2mm (0.8in.), about 0.7mm (0.03in.), or greater or lesser for example.

Irrigation channel 36 can have irrigation channel liner 136.Irrigation channel liner 136 can be on one's own initiative (for example, movably, for example electric activated polymeric skin) or passively the shape of passage lining 136 (for example, through) the stream thigh of the irrigation 32 of discharge is gathered.Irrigation channel liner 136 can form Venturi tube (venturi) 138 in irrigation channel 36.Irrigation channel liner 136 can form integral body with irrigation channel 36, perhaps attaches to irrigation channel 36 regularly or removedly.

In use, can be for example apply power to elasticity flushing connector 28 contiguous with irrigation storage 30 and/or that be incorporated into this irrigation storage 30 via pump 11 and customer controller 10 (will be discussed in more detail below).This power produces irrigation pressure 39, makes to flow out irrigation 32 irrigation channel 36 of flowing through irrigation ports 34, and get in the cavity of expectation.

Irrigation storage 30 can comprise different shape, and can form integral body with head 14 and/or main body 4, perhaps attaches to head 14 and/or main body 4 regularly or removedly.Irrigation storage 30 can hold irrigation 32.Irrigation storage 30 can be interchangeable box or ampoule bottle.Irrigation storage 30 can comprise Compressed Gas and irrigation 32.Irrigation storage 30 can be removable, use up that can abandon, interchangeable, reusable or their combination.Irrigation storage 30 can be pre-charged with irrigation 32, or ready, can add the component (for example, water) of all irrigations 32 or irrigation 32.Irrigation storage 30 can be divided into a plurality of sub-storages.For example, a sub-storage can contain salt, and another irrigation storage can contain water.When distributing irrigation, can be with the contents mixed in the sub-storage (for example, pickle making solution).

The volume of irrigation storage 30 can equal, be greater than or less than the volume of attractant storage 40.For example, the volume of attractant storage 40 can be than the volume of irrigation storage 30 about 100 times or less multiple, perhaps more accurately; Than the volume of irrigation storage 30 about 20 times or less multiple, perhaps more accurately, than the volume of irrigation storage 30 about 7 times or less multiple; Perhaps more accurately; Than the volume of irrigation storage 30 about 3 times or less multiple, perhaps more accurately, than the volume of irrigation storage 30 about 1.5 times or less multiple; For example, the volume of attractant storage 40 can be about 1.25 times of the volume of irrigation storage 30.The volume of irrigation storage 30 can for, for example, about 10mL, or more accurately for about 5mL, or be about 3mL more accurately, perhaps greater or lesser.

Irrigation storage 30 can be first color (for example, blueness), and attractant storage 40 can be first color or second color (for example, yellow or red).Irrigation storage 30 and/or attractant storage 40 can be transparent, translucent or opaque.Irrigation storage 30 can be installed in the head 14 with the structure that is different from attractant storage 40.For example, the remainder of irrigation storage 30, attractant storage 40 and head 14 can be provided with like this, so that can not use irrigation storage 30 to replace attractant storage 40 to insert in the head 14, and/or vice versa.

Flush fluid or irrigation 32 can have or for water, saline solution, zinc-containing solution (for example; Solution of zinc sulfate), alcohol, anesthetis, analgesic, antipyretic, antiinflammatory such as non-steroid anti-inflammatory agent are (for example; Ibuprofen, aspirin, salicylic acid, COX02 inhibitor, COX-3 inhibitor), acetaminophen, vaccine (for example; Gripovax,

), hydryllin (for example; A-5610 (azelastin hydrocholoride), corticosteroid are (for example; Fluticasone propionate), the external decongestant (for example; Oxymetazoline hydrochloride), vitamin (for example, vitamin c, ascorbic acid), nicotine, medical herbs, powder, other treatment or diagnostic medicine or their combination.

Irrigation 32 can make up with atomization gas and/or propellant 88.Most advanced and sophisticated 18 can be constructed to make irrigation 32 atomizings.Atomization gas can have or do, for example, and air, carbon dioxide, oxygen, nitrogen, nitrogen oxide, another kind of anesthetis, or their combination.

Can be included in through the irrigation 32 of atomizing that diameter is the granule of about 0.1 micron (0.004mil) to about 100 microns (4mil) when most advanced and sophisticated 18 discharge.Irrigation 32 granules through atomizing can have high fluidity, and can apply and/or adhere to target site, tissue and fluid basically equably, and with target site, tissue and fluid interaction.

Head 14 (for example, and/or controller 10 and/or pump 11) can be constructed to provide the flow behavior of various irrigations 32.For example, device 2 can be constructed to produce mighty torrent (flood) (for example, uninterrupted (unbroken); Or non-hollow (unhollow) stream thigh, the stream thigh of perhaps shower appearance, or substantially cylindrical); And/or atomizing, and/or taper (for example, the taper flow thigh of hollow or non-hollow) flushing characteristic.This flow behavior can be regulated by automatic or manual.Thereby can be manually with heteroid most advanced and sophisticated 18 or head 14 replacement flexible tip 18 or head 14 change the flushing characteristics.

Irrigation 32 can be not mix with atomization gas or not through one or more of nebulizer 88 do not atomize mighty torrent or stream strand or streamed sending.For example, device 2 can not have atomization gas or atomizing zone or other atomizing elements.

Figure 21 shows and can recharge irrigation 32.Irrigation storage 30 can have the irrigation storage sealing member 140 on the wall that is positioned at irrigation storage 30.For example, this irrigation storage sealing member 140 can be plastics.Irrigation storage sealing member 140 can be from movable sealing, and/or opens and closes through manual control.

Outside irrigation container 56 can be equipped with fresh irrigation 32.Irrigation container 56 can have the container mouth of pipe 57, and this container mouth of pipe is constructed to insert in the irrigation storage 30 through irrigation storage sealing member 140 and/or irrigation ports 34.Can irrigation container 56 be marched in irrigation storage sealing member 154 or the port 34, shown in arrow.Can the content of irrigation container 56 be left in then in the irrigation storage 30, for example carry out through extruding irrigation container 56 and/or through the pressure release port (not shown) of opening on the irrigation container 56.Then, irrigation 32 in the irrigation container 56 and Compressed Gas just can be transferred in the irrigation storage 30.Can remove irrigation container 56 from irrigation storage sealing member 154 or port 34 then, and can closed irrigation storage sealing member 140.

C. attract and the attractant storage

Except those characteristics of I & A and above-mentioned flushing storage 30 and attraction storage 40, attract storage and attract function can also comprise additional features.In some embodiments, attract storage 40 to be communicated with (seeing Figure 19) with attracting port 44 direct fluids via attraction passage 46.

As previously mentioned, shown flexible tip 18 comprises bar 80.Bar 80 (with flexible tip 18) can comprise irrigation channel 36 and/or attract passage 46.Attracting passage 46 also can be the parts of attractant storage 40, head 14, or independent parts, or any combination.The bar 80 of flexible tip 18 can be arranged to be communicated with attractant storage 40 fluids via attractant storage port 45.

Attract passage 46 can have attractant channel diameter 48.Attractant channel diameter 48 can be the minimum diameter of attractant passage 46.Attractant channel diameter 48 can be less than about 1cm (0.4in.), more accurately less than about 5mm (0.2in.), and for example about 3mm (0.12in.), perhaps greater or lesser.

In some embodiments, attract port 44 can have to the non-return that becomes a mandarin (that is, the unidirectional) valve 130 that becomes a mandarin, this valve is constructed to stop basically or fully attractant 42 to reflux from attracting passage 46 or storage 40.To go into flow check valve 130 can be globe valve, revolving valve, clack valve, umbrella valve, double check valve (DCV), duckbill valve or their combination or have globe valve, revolving valve, clack valve, umbrella valve, double check valve (DCV), duckbill valve or their combination.Going into flow check valve 130 can form integral body with attracting port 44 and/or attraction passage 46 and/or attractant storage 40, perhaps attaches to regularly or removedly to attract port 44 and/or attract passage 46 and/or attractant storage 40.

Attractant storage 40 can comprise different shape, and can form the whole remainder that perhaps attaches to device 2 regularly or removedly with the remainder of device 2.Attractant storage 40 can hold attractant 42.Attractant storage 40 can be replaceable cartridge or ampoule bottle.Attractant storage 40 can comprise pressure, for example vacuum.Attractant storage 40 can be removable, use up that can abandon, interchangeable, reusable or their combination.Attractant storage 40 can be divided into a plurality of sub-storages.In some embodiments, provide barrier device 24 mucous mobile thereby blade and/or deflection plate can be used for creating a plurality of sub-storages, but allow air to flow to block.In some embodiments, a plurality of sub-storages can be used for to the diagnostic equipment 22 required mucus sample being provided.

In use, via controller 10 (will be described in greater detail below) to attracting storage 40 exert pressure (that is vacuum).This vacuum has produced negative attractant pressure, causes attractant 42 shown in arrow, to be flowed through from processing region and attracts port 44, and flowing through attracts passage 46, and flows into and attract in the storage 40, and wherein attractant is collected in this attraction storage.As previously mentioned, barrier 24 is constructed to allow gas exchange path (for example air) but gets rid of fluid path (for example, attracting fluid and mucus), thereby attractant 42 is kept separating with main body 4.

D. diagnosis

Along with the increase of the concern that infectious disease is controlled, the ability of no intervention (hands-off) sample collection and analysis is more and more important.Device 2 can be suitable for providing this critical function.For example, the nose sample is delivered to the diagnostic equipment 22 (for example, detection platform) that is embedded in head 14 and the/main body 4, can combines various platforms, include but not limited to:

1.) lateral flow (Lateral Flow) immunochromatographiassays assays is as generally be used for those of respiratory virus infection (for example RSV, influenza) at present.

2.) Electrochemical Detection micro-array chip; When being exposed to power source via contact point; As when being arranged on the power source 6 times in the head 14, this chip original position produces biomolecular labeling, and this biomolecular labeling itself can be the labelling like hereditary material in virus, antibacterial and the fungus.It can also relate to and utilizes enzyme reaction to produce the signal of telecommunication, this signal of telecommunication can be directly from/this analysis, read.Replacedly, the independent card reader docking system (reader dock) that meets suitable electricity/luminosity standard can be used for identifying the biology of head 14.The card reader docking system can comprise independent device, or can be incorporated in the for example filled base portion 62.

3. the bonded microfluid tmRNA of amplification (NASBA) purification that) relies on nucleotide sequence, the amplification that this nucleotide sequence relies on has merged the real-time detection that utilizes the molecular beam fluorescent probe technique.This can be immersed on the chip, power source if desired, and for example, power source 6 can craniad 14 provide power via contact point.In addition, can have the contact in the head 14, button activation is pressed by independent " laboratory activation " on for example head 14 or the main body 4 in this contact.

4.) " biosensor " technology also can be embedded in the head 14 and can comprise and is coated with a kind of or several hereditary test boards to the antibody of target organism.When with reagent with contain biological sample combination and be exposed to illumination following time, visible change color takes place in it, so that do not need the external source detection of biological.

5.) on chip and/or test strip (strip) and/or hereditary test board and/or utilize chemicals that biological detection or chemico-analytic other known or biometric techniques of exploitation in the future are provided; For example; Can be placed in head 14 and/or the main body 4, not handle so that sample is had the intervention experiment.

These samples desirably do not need craft (handing) to be delivered to above-mentioned detection platform; But can utilize the pump in pressure apparatus such as the use device that sample is directed into the exact amount of sending needs in pressure-sensitive pallet/inlet (portal), this pressure-sensitive pallet or inlet are communicated with test platform in the accurate position that is used for suitably sending then.This action or process can occur over just when for example this head is positioned at ad-hoc location and/or this nozzle during by shutoff fully.

Replacedly, this sample can be delivered to test platform through hand gear, in this hand gear, shakes collecting chamber lightly, and what so make inside fills the aliquot of waiting to be the predetermined needs of passing test platform than cell.This final sending and to start like this: push or knock flexible portion in the side of head 14; For example " bubble shape cover (blister) "; And/or spring-loaded piston and/or button; The aliquot chamber that head 14 will before have been closed then is communicated with the fluid of test platform to be opened, thereby provides no intervention to move liquid.

Replacedly, this sample can be filled into simply towards the collecting chamber remainder open wide predetermined than in the cell.The part of test platform can extend to this than in the cell, but the test platform remainder can and be isolated by for example polypropylene wall sealing.As limiting examples; This sample can be via core sucting action (wicking) like lateral flow immunochromatography, capillarity such as microfluid capillarity, electric charge and/or via bubble shape cover breakdown point, film then; Or the dividing wall opened of sealing member, and advance in the test platform remainder.

The device 2 that comprises the diagnostic equipment 22 is very suitable for hospital and outpatient service use, and the self diagnosis in the family.The device 2 that comprises the diagnostic equipment 22 can be used to detect all types of microorganisms in medical science; In war, be used to provide weaponization antibacterial, medicament and virus; Be used in the emergency services; In high power capacity transportation place such as airport, be used to detect infected passenger, and in school and nursery school, be used for confirming infected student.Comprise and also can install the laboratory that detects collected sample such as the test platform of metabolism inspection, glucose, insulin level, levels of drugs, the sharp natriuretic peptide of b-, d-dimer and CRP in the device 2 of the diagnostic equipment 22.

After using (that is, attracting), head 14 and/or attractant storage 40 possibly contain contaminated fluid such as irrigation and mucus (that is, attracting fluid 42).Irrigation storage 30 and/or attractant storage 40; And/or whole head 14; Perhaps the miscellaneous part of head 14 or main body 4 can be used as then; And/or remove and be used as, contaminated fluid is tested and/or estimated to the diagnostic equipment to disease or medical condition, like the influence of damage, anergy, disorder, syndrome, infection and/or virus.If remove, can be to (one or more) that removed thus parts seal avoids cross-contamination.Allow lab assistant near fluid 42 to be tested.

As limiting examples, in some embodiments, head 14 and/or attractant storage 40 for example, can comprise the diagnostic equipment 22, like those of previous description, or any combination (seeing Figure 22 A～Figure 22 C).This diagnostic equipment can be embedded in head 14 or attractant storage 40 or the main body 4, perhaps can be the removable member that is used for further test and/or estimates.The diagnostic equipment 22 can provide the result immediately, perhaps can head 14 and/or the diagnostic equipment 22 be delivered to laboratory and be used for further action.

The diagnostic equipment 22 for example can comprise test platform or analytical system 90; Like lateral flow test strip analytical system (promptly; And/or micro-full analytical system (that is chip lab (labon a chip)) immunochromatography); And can combine microfluid (microfluidics), this microfluidic device comprises as the mechanical flow control device of pump and valve or as the pick off of effusion meter or viscometer.Chip lab can be processed by for example glass, silicone, pottery or metal.

Device 2 and the diagnostic equipment 22 can utilize attract function to carry out the nose suction with device 2 and fluid sample that scheduled volume attracts 42 submissions are simplified to the diagnostic equipment 22 and no intervention sample collection is provided through test process is simplified.After sample 42 submissions are given device 2, for example, in submission to the head 14 after, this sample can manually (for example, be exerted pressure), or automatically (for example, solenoid-activated) submission to the diagnostic equipment 22.In some embodiments; Can be for example in sample collection hole or capillary tube or the chamber 92 with sample 42 suction; For example through shaking head 14 (or installing 2) so that with in the fluid sample suction chambers 92 42; Or through with block 20 or point 76 and cover flexible tip 18, activate once more and attract function so that cause that suction is inaccessible, will attract in the fluid sample suction chambers 92 42.Sample in chamber 92 after, can supply analytical system 90 to utilize to test.This chamber can provide the fluid sample 42 of predetermined to analytical system 90.

After in chamber 92, the sample 42 of predetermined can be then automatically passs analytical system 90, perhaps possibly take some action; As manually knock bubble shape cover 94 in the side of head 14; Or the pushing button, or moving switch, thus make sample get in the analytical system 90 and/or above that.

In some embodiments, can there be one or more chambers to be communicated with, the layout of the diagnostic equipment 22 and sample collection room 92 and be communicated with and allow to extract out predetermined specimen size (amount) with the diagnostic equipment 22 fluids.Thereby can combining with the reagent from the one or more chambers in this chamber to form, this specimen sent aliquot then to analytical system 90.

In some embodiments, the diagnostic equipment 22 can show and/or appear the result of one or more tests then.For example, this result can with on the diagnostic equipment 22 and/or the head 14 or the change color form of indicator 95 wherein show, perhaps can from the diagnostic equipment, take out test strip 96, or can be in head 14 and/or attraction storage 40 observation test bar 96.Thereby electric contact 97 can be comprised to the diagnostic equipment 22 electric power is provided.

The diagnostic equipment 22 can provide microorganism testing, includes but not limited to: influenza A and influenza B, bird flu, RSV (respiratory syncytial virus), adenovirus, Legionnella (Legionella), CNV, EBV, A group beta hemolytic streptococcus, streptococcus pneumoniae, Neisseria meningitidis (N.meningitides), mycoplasma, staphylococcus aureus, malaria, HIV, rhinovirus, coccsackie virus, variola, anthrax, Botulinum toxin, Ricin, Ebola virus (ebola), rabies, brucellosis, (plague) Yersinia pestis, Coxiella burnetii (coxeillaburnetti) (Q heat), T2 mycotoxin, soil draw hot Francisella (francisella tularensis) (tularemia), viral equine encephalitis (viral equine encephalitis), viral hemorrhagic fever and burkholderia (burkholdria mallei) (glanders).

The diagnostic equipment 22 can provide toxicology and/or test chemical, includes but not limited to: amphetamine, cocaine, opiate, phencyclidine, tetrahydrocannabinol, acetaminophen, barbiturate, benzene phenodiazine

type (benzodiazepines), methadone (methadon), third oxygen fragrant (propoxyhenone), tricyclic anti-depressants, calcium channel blocker, ethanol, ethylene glycol, ketone, glucose, antidiabetic drug (hypoglaecemics), cytokine, interleukin, insulin, HbA1 C, electrolyte, hCG's (pregnancy tests), thyrotropin (TSH), T3 blood test, T4 blood test, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).

The diagnostic equipment 22 for example can comprise tests and/or immunoassay to the real-time polymerase chain reaction of virus, antibacterial and cancer.

B. power source

According to an expectation technical characterictic, device 2 can have power source 6.Figure 23 shows power source 6 can be stored in compartment wholly or in part, in the power source compartment in the main body 4.As limiting examples, power source 6 can comprise, power supply (for example, battery or capacitor) and/or mechanical power source (flywheel or the spring that for example, are used for storage power) and/or Compressed Gas (for example, compression gas tank).In some embodiments, power source 6 is the power sources that can fill again.This power source that can fill again can be non-removable (that is, device 2 is placed in power source and fills on the device 62 or wherein), and perhaps this power source that can fill more removable being used for fills and/or replace.

Fill that device 62 and/or base portion 4 can comprise respectively directly or sealing or inductive zone 98,99, thereby make the device 2 can electric coupling and/or be mechanically coupled to and be used for the filled device (seeing Figure 23 and Figure 24) that fills again.Filling device 62 also can be again filling device, and/or charger can be coupled on the external power source (for example, 120VAC wall socket).As limiting examples; Fill device 62 and (for example can comprise light source or lamp 100; LED) thus indication is provided, for example power source is connected, is filled and filled and accomplishes indication, and can be placed on the surface as perhaps be installed on the wall on desk or the counter top.As previously mentioned, fill device 62 and can incorporate the card reader docking system that the meets suitable electricity/luminosity standard part as the diagnostic equipment 22 into, this card reader docking system can be used for identifying the biology of head 14.Replacedly, this card reader docking system can comprise independent device, and/or can obtain power from filling device 42.

In a kind of interchangeable embodiment, as limiting examples, power source 6 can comprise one or more non-rechargeabel unit (for example, one or more batteries), for example, and four placed in-line AA alkaline batteries.

In some embodiments; Power source 6 can comprise lithium ion power source; And can be constructed under about 7.4 volts, provide about 100mAh or about 500mAh or about 750mAh or about 1000mAh or greater or lesser capacity; But it will be understood by those skilled in the art that power source 6 can be constructed to provide diversified voltage and capacity.Power source 6 expectations have enough capacity; So that for example for many or most of application, fill again and/or power source changes that frequency that operation takes place is not more than per 5 minutes once or per 15 minutes once or per 30 minutes once or per hour once or once a day weekly or every month once or annual.Power source 6 also can be constructed to be connected to external power source (for example, 120VAC wall socket).

Through power source compartment door (not shown), can be from the outside of main body 4 near the power source compartment.This power source compartment door can attach to main body 4 removedly.The power source compartment door can hingedly attach to main body 4.

Power source 6 can be electrically coupled to light source or lamp 102 (for example, LED), thereby indication is provided, such as but not limited to, power source is connected, power supply ability and flushing and/attract the indication of function activation.

C. Setup Controller

According to the technical characterictic of an expectation, device 2 can have controller 10, and this controller 10 can be constructed to provide multiple function (seeing Figure 25).As limiting examples, controller can comprise button, switch, trigger, control stick (lever), circuit, any interaction between them, and can comprise microprocessor controller 110.Controller 10 can make device 2 induced and/or self actuating by the user.For example, the device 2 can through with wait to wash and/or attract the zone, for example contact and activated with the nostril.As limiting examples, controller 10 can be coupled in difunctional switch, perhaps one or more multifunction switchs, perhaps one or more single functional switches or their combination.(one or more) switch 112 can comprise press button, rocker switch, rocker switch, trigger switch or other known structure and combining form; And can attach to main body 4 and/or head 14 or whole, or their combination with main body 4 and/or head 14 formation.

Controller 10 can be directly or indirectly manually (for example; The user is inductively) or automatically (for example; Electric, pneumatic, energy storage) activates flushing and/or attract function and/or for flushing and/or attract function that power and/or otherwise control flushing and/or attract function are provided.Controller 10 can be suitable for providing the variable control of flushing and/or attraction, and can comprise the delay that provides flushing and/or attraction, like the ability of adjustable delay.Controller 10 comprises switch 112, can be simple and easy to use.

Controller 10 (or other elements) thus can be used to transmit power active electron device (for example, pump 8, motor 9 and/or microprocessor 110), valve, manual pump or their combination in any from power source 6.Controller 10 can be constructed to receive the input signal from one or more buttons 112.

Figure 26～Figure 29 shows the illustrative embodiments of device 2 methods for using.As shown in the figure, controller 10 can produce first input signal, for example, button 112 push conversion (pressingtranslation) 114.Controller 10 can produce second input signal, and for example, conversion 116, the second input signals of pushing of switch 112 are different from first input signal.First input signal can be controlled flushing, and whether for example to irrigation is discharged in 14 from the head, and/or the frequency of flushing flow and/or volume are controlled.Second input signal can be controlled attraction, for example open or close attracting, and/or the intensity of pressure and/or attraction flow velocity is controlled.

In a kind of interchangeable embodiment, controller 10 can receive first input signal, and for example, pushing of button 112 changes 114.Controller 10 can receive second input signal, and for example, conversion 116, the second input signals of pushing of button 112 are different from first input signal.First input signal can be controlled flushing, for example whether irrigation is discharged (that is, opening or closing) in 14 automatically from the head, and/or the intensity of pressure and/or irrigation flow velocity and/or flushing flow frequency are controlled.Second input signal can be controlled attraction, for example to attracting to open or to close and/or the intensity of pressure and/or attraction flow velocity are controlled.

Figure 26 illustrates, and the user can grip to singlehanded ergonomic main body 4.The user can say finger 76 or thumb 77, for example is placed on the button 12, with referring to that singly (that is, point 76 or thumb 77) control button 112.Palm 74 and/or other fingers 76 can substantially or abut in fully and grip on the pad 78.

For instance, Figure 27 shows the first that thumb 77 can pressing button 112, shown in arrow 114.Pushing of button 114 can be controlled not by the flushing of pushing 116 controls and/or another person in attracting.As directed, for example, pressing button 112 can cause pressure fluid to be sent to produce the pressure of irrigant stream 118 to produce by actuating device 2.Release-push 112 push 114, can end sending of pressure fluid.Button be pressed 114 inside distance can with attract or the pressure and/or the volume of flushing directly or indirectly relevant.

For instance, Figure 28 shows the second portion that thumb 77 can pressing button 112, shown in arrow 116.Pushing of button 112 116 can be controlled flushing and/or attract.As directed, for example, pressing button 112 can cause that with generation attractant flows 120 suction by actuating device, shown in arrow 120.Release-push 112 push 1164, can end suction and flow with attractant.Switch 112 be pressed 116 inside distance can with attract or the pressure and/or the volume of flushing directly or indirectly relevant.

For instance, Figure 29 show thumb 77 can be shown in arrow 114 and 116 first and the second portion of pressing button 112 so that the first and the second portion of parallel press push button 112.Parallel first of pushing 114 buttons 112 can send to produce pressure fluid by actuating device 2 with the second portion of pushing 116 buttons 112, and this pressure fluid is sent and can be produced irrigant stream 118, and causes the suction that produces attractant stream 120 concurrently.

Replacedly, thumb 77 can pass through 114 and 116, and the alternately first and the second portion of pressing button 112 perhaps move around between 116 and 114.The first of pushing 114 buttons 112 through moving around can send to carry out pressure fluid by actuating device 2 with the second portion of pushing 116 buttons 112; This pressure fluid is sent and can be produced irrigant stream 118, progressively causes producing the suction of attractant stream 120 then.

In a kind of illustrative embodiments shown in Figure 25, button 112 can comprise first switch 122, and this first switch 122 is configured to for example attract the pressure (that is suction pressure) in the passage 46 via pump 8 controls.First switch 122 can comprise variable power switch, and this variable power switch is suitable for control and attracts function, comprises attracting to open or the pass and/or the intensity of pressure and/or attract flow velocity to control.Button 112 can have second switch 124, and this second switch 124 is configured to manual activation second pump 11 with delivery pressure, directly or indirectly is delivered to irrigation storage 30 and irrigation channel 36.Second switch 124 can comprise one or more elements 176,178, and this element is suitable for move (for example, through pushing) of button 124 is transformed in the pump 11, sends so that cause the pressure fluid that can produce irrigant stream 118.As described in the preceding text to button 112; For example first switch 122 can activate through first finger (for example, thumb 77), and second switch 124 also can be through first finger (for example; Thumb 77); Or second finger (for example, forefinger 76) activates, thus to flushing with/attract function to carry out independent or parallel control and control.

Should be understood that one or more buttons can enough fingers (that is, finger 77 or thumb 78) control attractions (that is, aspirating) and wash.Button 112 can be configured to receive a plurality of input signals (for example, from the user).Button 112 can have one, two or more degree of freedom.For example, button 112 can receive pushes switching signal (pressing translation), and/or slip switching signal (sliding translation), or combines.Controller 10 via a plurality of input signals (for example; Push and slide); Can be constructed to control individually (for example, as limiting examples, the binary that the magnitude of power is increased gradually or reduce/bifurcation control (ON/OFF) and/or variable control) attract and flushing.For example, input signal (for example, push or slide or the two) can be controlled attraction, and another input signal (for example, push or slide or the two) can be controlled flushing.This slip can be carried out along the longitudinal axis of main body 4 and/or head 14.As limiting examples, this is pushed and can carry out perpendicular to this slip.

Button 112 can be bifunctional.Button 112 can have the rocking bar platform, thereby can varying speed switch be contained in the variable control that flushing is provided in this platform and/or attracts.Through varying speed switch is slided along this platform, can make varying speed switch move to maximal rate (and/or ON/OFF) state from closed condition.This platform can flush with the shell 5 of device 2, and is inner or outside at shell 5.This platform can be hinged with first end, and the second end is freely.This platform can flexibly be pressed to the remainder of device 2, for example, crosses balancing spring (hairspring, balancing spring).Push this platform can manual activation flushing with/attract the self actuating that perhaps activates flushing and/or attract.

D. pump

According to the technical characterictic of an expectation, device 2 can have one or more pumps 8 and 11 that are configured to provide pressure.First pump 8 can produce and similar and different flow velocity and/or the pressure of second pump 11.

In some embodiments, pump 8 can be, for example piston pump, rotary vane pump, linear pump and/or membrane pump (that is, membrane pump, positive-displacement pump) are like twin-diaphragm pump 8, like Figure 30～shown in Figure 32.Pump 8 can have axle, bar or the film of at least two inverted orientation swings.In other embodiments, pump 8 can be or have Compressed Gas (for example air, carbon dioxide, nitrogen) jar 210 that this jar can be configured to controllably store and discharge Compressed Gas.

Pump 8 can pass through motor 9 directly or indirectly, is connected to controller 10 and perhaps is connected with controller 10 interfaces.Selected motor 9 should make the rpm of expectation and acceptable current drain (currentdraw) match.Of preamble, controller 10 can comprise microprocessor 110, controls irrigation delivery pressure and/or attractant swabbing pressure thereby this microprocessor is configured to regulate and/or changes motor speed.Attractant swabbing pressure by pump 8 produces can; For example, up to 200mm Hg (3.86psi) or more accurately for about 120mm Hg (2.32psi) or more accurately for about 80mmHg (1.55psi) or be about 50mmHg (0.966psi), perhaps higher or lower pressure more accurately.Controller 10 can receive the one or more input signals from button 112.Thereby microprocessor 110 can analysis button position control motor speed.As previously mentioned, thus pump 8 and/or controller 10 can be incorporated valve 128 into or control algolithm is restricted to for example about 100mm Hg with the attractant swabbing pressure.

As limiting examples, pump 8 can have the barrier film of bilayer (doubled-up).Pump 8 is energy supply and/or electricity consumption generation power manually.Can pump 8 be attached to the motor 9 of AC or DC-driving.Pump 8 can be driven by motor 9, and this motor 9 can be driven by power source 6.Pump 8 can have one or more aerators, turbine, fan, barrier film, corrugated tube or their combination.

A kind of illustrative embodiments of pump 8 is found in Figure 30 and Figure 31.Laid the swing barrier film of two inverted orientation in the pump chassis 150.For for simplicity, the structure (that is, the left side) of pump 8 one sides has been described, opposite side is mirror image (that is right side).The both sides that should be understood that twin-diaphragm pump are not necessarily mirror image.Be provided with in the pump chassis 150 and throw pin (throw pin) 152, barrier film arm 154L rotatably is incorporated into and throws pin 152.Barrier film arm 154L comprises the barrier film arm height H of optimization.Shown in barrier film arm height H be to measure from center to the top surface of barrier film 156L that the barrier film arm is thrown pin shaft hole 153, and can have about 4～8mm, or be about 5～7mm more accurately, or be about 6.5mm more accurately, perhaps greater or lesser length.Barrier film arm height is short more, and barrier film 156L not desirably " does not wave (rock) " more, and the barrier film arm is long more, and the size of pump will increase thereupon.Can as far as possible advantageously reduce barrier film arm height, it is directly related that the limit that shortens barrier film arm height and barrier film arm diameter D and every stroke barrier film wave how many times.

Advantageously, also can optimize barrier film 156L, make its diameter be D and having be roughly " M " or " S " thus cross sectional shape regulate oscillating motion (seeing Figure 31) most effectively, and release most of air and suck most of air at every stroke.Barrier film 156L can be clipped between barrier film arm 154L and the diaphragm plate 158L.Barrier film 156L comprises the diameter D of optimization, and can have about 20～40mm or more accurately for about 25～35mm or be about 30mm, perhaps greater or lesser diameter more accurately, diameter is every stroke flow that the barrier film 156L of D can provide optimization.The diameter D that optimizes is adapted to be mounted within the base portion 4 this pump, and this pump can be turned round with minimum possible RPM when the expectation traffic demand is provided.Diaphragm plate 158L provides the rigid central region of barrier film 156L.Diaphragm plate 158L has also improved efficient because of helping to guarantee that all air all are pushed out and suck in every stroke.If there is not diaphragm plate 158L, barrier film 156L only can extend and/or deflection.

Chamber of septum 161L can be placed on that barrier film 156L goes up or with barrier film 156L placed adjacent, unidirectional umbrella valve 159L of air inlet and the unidirectional umbrella valve 163L of aerofluxus are arranged on each side of chamber of septum 161L.The use of unidirectional umbrella valve and chamber of septum helps the thickness of pump 8 is reduced to minimum.Manifold backing plate 165L and pump manifold 164L can be installed on chassis 150, and drain hose 166L and/or get into flexible pipe 170L and can be incorporated into manifold 164L.And this structure or like configurations repeat at the opposite side of pump 8.Get into flexible pipe 172 and can extend to attraction hole 192 through main body 4 then.Thereby throw pin 152 and can be incorporated into the membranous oscillating motion that motor 9 provides the inverted orientation swing.

The macromesenterium of the high amplitude of oscillation (throw) can produce the high fluidity of the low capacity of expectation.Since spatial physical restriction in the base portion that limits 4, be limited so increase the ability of tame diaphragm diameter.High fluidity for low capacity that expectation is provided; Can be to being clipped in highly to the diameter between the barrier film arm 154L of H and the diaphragm plate 158L is that the structure of the backing plate 156L of D is optimized, thus provide improved high level stream with high level swing or amplitude of oscillation mobile.Relation between diameter D and the height H can be expressed as the ratio of D/H, wherein this ratio can for about 2/1 to about 10/1, more accurately be about 4/1 to about 6/1, more accurately for about 5/1, perhaps greater or lesser.This improvement performance of this kind device is that existing apparatus can't obtain.

In some embodiments; Thereby can so can make the displacement maximization through utilizing described pair of barrier film structure, the rpm of pump 8 is increased to only is enough to satisfy the degree of required flow and utilizes unique barrier film that foregoing every stroke flow is increased with difformity and diameter.

Pump 8 can have total capacity.For example, the capacity of pump 8 can be about 100cc (6.1in ³), more accurately for about 75cc (4.6in ³) and be about 50cc (3.05in more accurately ³), perhaps greater or lesser.

Figure 32 shows a kind of replaceable embodiment of pump 8.Except chamber of septum 160L with flat valve 162L interface is connected, this replaceable embodiment is similar with pump 8 shown in Figure 31 with Figure 30.

The illustrative embodiments of pump 11 can be shown in Figure 33 and Figure 34.Pump 11 can be directly or through button 112 and/or switch 124 indirectly, is connected in controller 10 or is connected with controller 10 interfaces.One or more pivotal arms, thus can be caused and made pivoting action directly or indirectly like first pivotal arm 177 and second pivotal arm 178, for example apply power 180 to flushing storage 30 through flushing corrugated tube 68.Installing plate 182 can provide first pivotal point 184 of first pivotal arm 177 and second pivotal point 186 of second pivotal arm 178.In some embodiments, (also visible Fig. 8 C) can partially or completely be extended through the flushing hole in the installing plate 182 190 in the non-hub switch side 188 of second pivotal arm 178.To move 114 converting to force 180 downwards thereby button 112 can push or push 114 through the user, this power is through interface zone 13, and via the non-hub switch side 188 of second pivotal arm 178 approaching corrugated tube 68.As directed, flushing hole 192 provide attract vacuum 49 through interface zone 13 and from the head 14 extend to base portion 4 path.

E. flow chart

According to the technical characterictic of an expectation, Figure 35 A and Figure 35 B show device 2 can be suitable for providing partially or completely isolating flushing and attraction system and function.As directed, I & A stream can keep separated from one another, so institute's generator can be avoided cross-contamination.As previously mentioned, this flushing and/or attraction system and function can have the interface zone 13 between main body 4 and head 14.This interface zone for example can be connected in pump 11 flushing storage 30 and/or vacuum pressure 49 is connected in attraction storage 40 directly or indirectly.Interface zone 13 can be suitable for providing isolating wholly or in part flushing and attraction system and function.

In some embodiments, irrigation 32 can directly or indirectly put under the effect of the mechanical pressure 180 on the irrigation storage 30 via controller 10 and pump 11, from irrigation storage 30, discharges (seeing Figure 35 A).In other embodiments, irrigation 32 can put under the effect of the mechanical pressure 180 on the irrigation storage 30 through user's extruding, from irrigation storage 30, discharges (seeing Figure 35 B).Can comprise or not comprise pump 11.Irrigation 32 flows out from irrigation storage 30, the irrigation channel 36 of flowing through, and from irrigation ports 34 outflows.Can be concurrently or before or after or any combination, for pump 8 energy supplies (for example, via controller 10 and motor 9) attract vacuum pressure 49 to produce, thus with air and attractant 42 from processing region in the suction attractant storage 44.Shown in arrow, gained vacuum 49 can extract attractant stream 120 through attracting port 44, and suction attractant storage 40.Barrier 24 can prevent that contaminated attractive material 42 (that is fluid) from getting in the main body 4.

Figure 35 A shows device 2 can have first pump 8 and second pump 11.First pump 8 and/or second pump 11 can be manual or automatic (for example, through electrical motor driven).For example, first pump 8 can be automatically, and second pump 11 can be manual, and is as directed.First pump 8 can get into flexible pipe 172 to attractant the attractant swabbing pressure is provided.The output pressure of first pump 8 can and/or be discharged port 168 and discharge through drain hose 166.

Second pump 11 can be to 32 pressurizations of the irrigation in flushing storage 30 and/or the irrigation channel 36.The power 180 that second pump 11 is produced shown in arrow for example uses hands (for example, the thumb on the button) to activate.Second pump 11 can activate through the thumb on the button 112 on the main body 4 of device 2 77.Irrigation 32 can be sent from irrigation ports 34 with non-atomized flow thigh or Sprayable, perhaps can irrigation 32 through or discharge the back from flexible tip 18 it atomized.

Button 112 can be positioned at the position that is configured to produce attraction and does not produce flushing.Button 112 can be positioned at the position that is configured to produce the flushing and does not produce attraction.Button 112 can be positioned at and be configured to produce the position that attracts and wash.Come all or part of discharge currents 170 that can be used as shown in arrow of the discharge pressure of self-pumping 8 to flow out from installing 2.

The separation of I & A function makes device 2 can be configured to stop irrigation 32 in the irrigation storage 30 only because of at head 14, the vacuum pressure 49 that more specifically applies in attractant passage 46 and the attractant storage 40 and flowing.

V. other embodiment

A. spherical designs

It can be elastic container that Figure 36 shows attraction storage 256, like the spherical thing 314 of elastomer.Attract storage 256 can have the conduit 340 of discharge.This is discharged conduit 340 and can be communicated with attracting storage 256 fluids.Discharging conduit 340 can have dump valve 342 and discharge port 344.Dump valve 342 can be to be configured to from attractant storage 256 effusive check-valves.

Nozzle 259 can form the whole attraction storage 256 that perhaps can attach to removedly with attracting storage 256.Attract port 260 nozzles 259 or attract storage 256 can have suction valve 346.Suction valve 347 can be a check-valves, for example, and umbrella shape check-valves 347.

Rinsing module 320 can have flushing trigger 348.Flushing trigger 348 can be controlled through single finger.When pulling or extruding flushing trigger 348, rinsing module 320 can distribute irrigation 257.

When extruding attracted storage 256, suction valve 347 can be closed, and dump valve 342 can be opened.Attract the attractant 258 in the storage 256 to receive to compel to discharge with discharging the port 344 from discharging conduit 340.Dump valve 342 can be a duckbill valve.When the attraction storage 256 of previous extruding relaxed, dump valve 342 can cut out, and suction valve 347 can be opened.Suction can attract port 260 places to take place then, and attractant 258 can be drawn into and attract in the storage 256.

It can be duckbill valve (rinsing module 320 is not shown) that Figure 37 shows suction valve 347.Rinsing module 322 and/or this device can have base portion 350.Base portion 350 can be configured to make device 2 for example can be erected on the flat surface (for example desk), attracts port 260 and other ports away from flat surface thereby make.

Figure 38 shows and attracts storage 256 can be arranged in elasticity vacuum sphere 364.Vacuum sphere 364 can be an elastomer.Attract storage 256 can, for example be communicated with irrigation storage 254 fluids via flushing-attraction port 366.Flushing-attraction port 366 is configured to away from the irrigation fluid horizontal plane in the irrigation storage 256.

Flushing-suction valve 368 can be communicated with attracting storage 256 and irrigation storage 254 fluids.Flushing-suction valve 368 can be a check-valves.Flushing-suction valve 368 can be the stream that only allows from attraction storage 256 to irrigation storage 254, and stops the valve from irrigation storage 254 to the stream that attracts storage 256.

Suction valve 346 can be to allow to flow into the check valve that attracts storage 56.

Irrigation storage 254 can be arranged in irrigation container 370.Irrigation container 370 can be inflexible, for example plastic bottle.Irrigation container 370 can install remainder with this and form integral body or attach to this device remainder removedly at storage joint 372 places that can be attached.Atomizing fluids storage 374 can be the top of irrigation storage 254, is positioned on the horizontal plane of irrigation 257.

Base portion 350 can extend from the storage container.Base portion 350 can ratio device 2 remainders the wideest part wide.

Extruding vacuum sphere 364 can make irrigation 257 atomizings and spray from atomizing port 246.For example, when vacuum sphere 364 was squeezed, flushing-suction valve 363 can be opened, and irrigation storage 254 can be pressurized via flushing-attraction port 366.The pressure that increases house in the irrigation storage 254 can cause irrigation 257 to flow through irrigation channel 224.The pressure that increases in the irrigation storage 254 also can force the gas (for example, the gas above the irrigation 257) in the irrigation storage 254 to pass through nebulization channel 220.

Make the flushing-suction valve 368 of previous extruding lax, can attractant 258 be drawn in the attraction storage 256.For example, flushing-suction valve 368 can be closed.Attract negative pressure in the storage 256 can be through opening the attraction sealing member 294 that attracts in the port 260 suction attractant 258.

Figure 39 shows one or more cover caps 375 and can be configured to cover on attraction port 260 and/or irrigation ports 248 and/or the atomizing port 246.

Device 2 can have the dump valve 376 of can be manually or controlling automatically.Two dump valves 376 can be passive or active.Two dump valves 376 can be discharged too high fluid pressure the conduit 340 from attracting storage 256 and/or irrigation storage 254 to be adjusted to.The discharge currents that too high fluid pressure can be used as shown in arrow is discharged from discharge conduit 340.

Flushing valve 378 can be regulated from irrigation storage 254 to irrigation ports 254 stream.Flushing valve 378 can be disposed and is used to stop irrigation 257 to discharge from irrigation ports 248 with too high pressure.Can stop the stream thigh of irrigation 257 streams to be discharged from installing 2 with excessive speed.

Figure 40 and Figure 41 show attractant storage 256 can be arranged in irrigation storage inwall 380.Irrigation storage 254 can be between irrigation storage inwall 380 and irrigation storage outer wall 382.Irrigation storage inwall 380 can be inflexible, elastic or deformable with irrigation storage outer wall 382.

Device 2 can have atomizing entry port 384 on its outer surface.Atomizing entry port 384 can be communicated with atomizing fluids storage 374 fluids.Atomizing entry port 384 can have check-valves, and this check valve configuration is used to allow the way flow from atomizing entry port 384 to atomizing fluids storage 374.

Atomization valve 386 can be regulated from irrigation storage 254 to nebulization channel 220 stream.Nebulization channel 220 can have with irrigation ports 248 adjacent venturi constructs 385.Can atomize irrigation 257 and/or increase the speed of atomization gas of venturi 385.

Irrigation valve 378 can be regulated the stream between irrigation storage 254 and the irrigation passage 224.Irrigation valve 378 can be a check-valves.Irrigation valve 378 can stop the stream from irrigation passage 224 to irrigation storage 254.Irrigation valve 378 can allow the fundamental freedom stream from irrigation storage 254 to irrigation passage 224.Irrigation valve 378 can limit the stream from irrigation storage 254 to irrigation passage 224; Except the stream under the high pressure drop; This high pressure is reduced to; For example greater than the pressure drop of about 25mmHg (0.5psi), more accurately greater than the pressure drop of about 100mmHg (2psi), more accurately greater than the pressure drop of about 260mmHg (5psi), be pressure drop more accurately greater than about 760mmHg (14.7psi), for example, greater than the pressure drop of about 1600mmHg (30psi).

Advancing irrigation port 388 can be communicated with irrigation storage 254 fluids.Advance irrigation port 388 and can have check-valves, this check valve configuration is used to allow from advancing the way flow of irrigation port 388 to irrigation storage 254.Irrigation storage 254 can be through filling via advancing irrigation port 388 introducing irrigations 257.

Attract passage 226 can have valve transition region 390.Valve transition region 390 can be configured to the smooth transition from the inwall that attracts passage 226 to the inwall of attractant valve 346.

Dump valve 342 can be regulated attractant storage 256 and discharge the stream between the port 344.The user can (for example, through point 76, like thumb 77) cover discharge port 344 or throw off cover cap during use.Discharge can be flowed out through discharging port 344, shown in arrow from attractant storage 256.

Can push Figure 40 and thereby device shown in Figure 41 2 is sent irrigation 257.To install 2 from be squeezed the structure unclamp and can attract.

Figure 41 shows irrigation 257 can be mixed through mixing valve 392 with atomizing fluids.Mixing valve 392 can be positioned at the upper reaches of atomizing port 246.

Figure 42 shows through for example using one or more fingers 76 (for example, forefinger and/or middle finger) to make trigger 245 on hinge, rotate 508, can actuating device 2, and modification shown in figure 36 is carried out flushing.Compression 241 through for example carrying out shown in arrow with thumb 77, the third finger, little finger of toe and 74 pairs of attractant storages of palm 256 can make attractant storage 256 emptying wholly or in part.Compress attractant storage 256 through discharging, can attractant 258 suction be attracted in the port 260.

Through extruding (for example, be used for flushing) with discharge (for example, being used for attracting) and install 2 elastic part, all or part of like sphere 314, modification that can actuating device 2, those shown in Figure 36～Figure 42.

B. long-range head

Figure 43 shows device 2 to have available lead-in wire 200 and is incorporated into the head 14 on the main body 4, and/or head 14 can be incorporated into for example independent vacuum source, on wall type vacuum pump and/or portable vacuum pump.This embodiment can incorporate disclosed any and all characteristics of description of device 2 into, but this embodiment comprises the other characteristic that long-range head 14 is provided.

Lead-in wire 200 can carry irrigation passage 36, and/or attractant passage 46, and/or is incorporated on the controller 10, and/or is incorporated on the wall type vacuum source and/or is coupled on the portable vacuum pump, or its combination.Lead-in wire 200 can be flexible.Lead-in wire 200 can, as utilize the contractile mechanism of spring loading to be retracted in the main body 4.Lead-in wire 200 can be rolled into coil.

Head 14 can have attached removedly attractant storage 40 and/or irrigation storage 30.Head 14 can comprise with the handle 202 of helping use and control head 14 and/or main body 4.Head 14 and/or handle 202 can comprise being used to produce makes irrigation discharge the pump 204 of required irrigation pressure.Thereby can push this head generation makes irrigation discharge required irrigation pressure.

Main body 4 can be any shape easily, and can have the flat base 206 that is used to support.Main body 4 can, for example attach to the surface like flat surface (for example on ground, desk, the fence (crib) with screw, nail, brad, bolt or its combination.Main body 4 can be equipped with ballast (ballast) and/or have anchor clamps (for example, for stable).

C. two most advanced and sophisticated nozzles

Figure 44 shows device 2 can have and comprise more than one nozzle, i.e. flexible tip, as shown in the head 14 of two flexible tip 194,195.Some embodiment can incorporate disclosed any and all characteristics of description of device 2 into, but some embodiment comprise the other characteristic of double-flexibility most advanced and sophisticated 194,195.

Simultaneously or wash and aspirate the target area off and on, for example, nasal cavity from a nostril to another and/or hole chamber possibly be favourable.Two most advanced and sophisticated 194,195 enter in the nostril irrigation 32, simultaneously or off and on it is attracted (seeing Figure 45) from another nostril.

In certain embodiments, mist to the high capacity flow thigh form that flush fluid 32 can irrigation 32 provides.Irrigation 32 is discharged continuously or with pulse mode.Attraction can be continuous or intermittent.The time of can automatic or manual setting I & A process in the cleaning cycle (that is I & A).

D. supply replacement pressure

Some embodiment that Figure 46 shows device 2 can have and comprise the trigger that is suitable for producing the pressure that enough attraction and/or washing capacity use or the pump structure of handle 208.Handle 208 can be used for producing any or two kinds in malleation or the negative pressure.This pressure can be stored in when producing in container or the jar 210, discharges via for example controller 10 then, and perhaps, this pressure can produce when needed.Handle 208 can be incorporated into pump; On foregoing pump 8 and/or pump 11; And/or this handle can be incorporated into bonded corrugated tube of check valve or deflection plate on, perhaps alternatively be incorporated into to be designed for and produce relative constant compression force for example on the fly wheel pump of vacuum.

Some embodiment that Figure 47 shows device 2 can have and comprise jars 210 or the pump structure of other supply containers of Compressed Gas (for example, air, carbon dioxide, oxygen and/or nitrogen).The embodiment of device 2 can dispose and be used for controllably producing compressed and supplied gas, but thereby vacant lot discharges this Compressed Gas generation Venturi effect then, make the pressure that enough attraction and/or washing capacity are used thus.

In some embodiments, this Compressed Gas is manually produced by the user.For example, handle 208 can be used for producing air under pressure, and this gas is used for using immediately or being stored in jar 210.As previously mentioned, elastic container can be used for making and/or stores compression gas like the spherical thing 314 of elastomer.

In some embodiments, this Compressed Gas can be removable and interchangeable, and/or produce automatically.For example, jar 210 can be to contain removable and interchangeable pressurization (snap-in) jar of supplying with Compressed Gas to some extent, when the supply Compressed Gas exhausts, and new jar of replacing of jar 210 usefulness.Fill base portion 62 again and also can comprise the high-pressure pump that fills jar 210 with new compressed and supplied gas again.

Figure 48 A～Figure 49 B shows a kind of replaceable embodiment of device 2, and it can have the deflection plate that comprises the pressure that is suitable for producing enough attraction and/or flushing usefulness or the pump of corrugated tube 214.Corrugated tube 214 can be used for producing negative pressure and malleation any or two kinds.As previously mentioned, this pressure can be stored in when producing in container or the jar 210, discharges via for example controller 10 then, and perhaps this pressure can produce when needed.Corrugated tube 214 can be incorporated into pump, on aforementioned pump 8 and/or pump 11, thereby and/or corrugated tube 214 can combine to produce relative constant compression force, for example vacuum with check valve.Figure 48 A and Figure 48 B show corrugated tube and are arranged on embodiment and corrugated tube on the device 2 easily through user's the hands or the embodiment of finger control.Figure 49 A and Figure 49 B show corrugated tube and are arranged on the base portion place of device 2 or near embodiment.

VI. operation instruction

Operation instruction 58 can instruct the use of I & A device 2, comprises being suitable for device 2 hand-held and available one or more fingers (that is, finger 76 or thumb 77) control.This operation instruction can comprise the explanation of for example in nasal cavity, washing and/or attracting.This operation instruction also can comprise uses head 14 as the diagnostic equipment, for example is used for the explanation of the inclusion of test head 14 and/or attraction storage 40, as will be described below.

Figure 26～Figure 29 illustrates the representative embodiments of the step that representative operation instruction can incorporate into or instruct.

A. I & A

This description can comprise the series of steps that flushing and/or attraction program can be acted in accordance with it.Should be understood that device 2 can only be used for flushing, or only be used for attracting, or be used for flushing and be used for attraction then, or be used for attracting and being used for flushing then, or be used for I & A simultaneously.This description provides for the people's of control device 2 interests, and the people of control device 2 can be user or patient, and perhaps this user is the patient.These steps include, but are not limited to:

(i) confirm that I & A device 2 contains the flush fluid 32 that expectation is supplied with;

Confirm that (ii) device 2 can turn round, confirm that the flowability of flush fluid 32 is available with attracting suction thereby this can comprise through pressing button 112, so test attracts function and washing capacity;

(iii) flexible tip 18 is arranged in the vestibule of nostril, thereby and the power that inwardly applies make ball tip 82 and nostril sealing lightly; Can use all places, for example for using to the baby, user can be sat in bed, and the baby is placed between two lower limbs, fixes baby's head with a hands, with another hands operative installations 2; Perhaps, the baby is wrapped in the blanket, be placed on the infanette (changingtable), fix baby's head with a hands, with another hands operative installations 2; Perhaps, user is held the baby, its head is placed in the axillary fossa and with arm be placed on baby's arm, with another hands operative installations;

(iv) use controller 10, for example in the first of button 112, apply downward power 114, thereby the flush fluid in the flushing storage 30 is entered in nasal cavity and/or the hole chamber through most advanced and sophisticated 18 with thumb 77;

(v) reuse controller 10; For example on the second portion of button 112, apply downward power 116 with thumb 77; Thereby attraction fluid 32 in nasal cavity and/or the hole chamber and mucus (that is, attracting fluid 42) are attracted in the storage 40 through most advanced and sophisticated 18 suction thereby produce suction pressure;

(vi) when confirming that flushing storage 30 contains the flush fluid 32 of supply, and attract storage 40 to contain when supplying to attract the space of fluid 42 usefulness in addition, as required repeating step (iv) with (v);

(when vii) needing, can in flushing storage 30, recharge flush fluid 32 (maybe can remove flushing storage 30) with 30 replacements of full flushing storage, and can be with attracting storage 40 emptyings (maybe can remove attraction storage 40, draw storage 40 replacements with suction);

(viii) randomly, can be simultaneously abide by step (iv) with (thereby v) carry out I & A simultaneously.

(ix) after the use, flushing storage 30 and/or attraction storage 40 can remove, and/or replacement, and/or cleaning is used for reuse.

This description can comprise and is used to replace the series of steps that nasal sinuses content and the thorough I & A program in cleaning hole chamber can be acted in accordance with it.These steps can be used, and make flush fluid in the Venturi effect that moves rapidly when the hole mouth, thereby and with flush fluid displacement nasal sinuses inclusion (that is, mucus), be similar to Pu Luaicishi (Proetz) replacement procedure.

These steps can comprise above-mentioned steps, can also include, but are not limited to:

(i) confirm that I & A device 2 contains the flush fluid 32 that expectation is supplied with;

Confirm that (ii) device 2 can turn round, confirm that the flowability of flush fluid 32 is available with attracting suction thereby this can comprise through pressing button 112, so test attracts function and washing capacity;

(iii) let under the patient lies, head is placed on snuff position (snuff position);

(iv) flexible tip 18 is arranged in the vestibule of nostril, thereby and the power that inwardly applies make ball tip 82 and nostril sealing lightly;

(v) use controller 10, for example in the first of button 112, apply downward power 114 with thumb 77, thereby thereby the flush fluid of flushing in the storage 30 entered in the side of nose through most advanced and sophisticated 18 fills nasal cavity;

(vi) simultaneously or only after this; Reuse controller 10; For example on the second portion of button 112, apply downward power 116 with thumb 77, thereby thereby producing suction pressure aspirates the nose opposite side, clog the nostril of normal saline washing simultaneously with gap; About 3～5 seconds of each suction is till pleasing oneself to the result that finds time.When aspirating, let the patient say that " K-K-K-K " can be helpful, because this can make paddy (vallecula) sealing and obtain closed more loop.

B. diagnose contaminated fluids

This description can comprise the series of steps that the contaminated fluids diagnotor can be acted in accordance with it.Should be understood that this diagnotor can automatically perform through the diagnostic equipment 22, be described below, perhaps can attractant storage 40 and/or head 14 be removed and deliver to laboratory and be used for further test.These steps include, but are not limited to:

(i) operative installations 2 (seeing top explanation) attracts at least, thereby the attraction fluid 42 that will supply with is collected in the attraction storage 40,

(ii) will attract fluid 42 directly to be and pass the diagnostic equipment 22; Perhaps at first with in the fluid 42 suction sample rooms 92; This can be through shaking head 14 (or installing 2) so that accomplish fluid sample suction chambers 92 42; Perhaps with block 20 or point 76 and cover flexible tip 18, and activate once more and attract function, so will attract in the fluid suction chambers 92 42 so that the shutoff suction takes place;

After (iii) the fluid 42 of scheduled volume being arranged in chamber 92; This can confirm through this chamber size in advance; Part as the diagnostic equipment 22; Analytical system 90 these fluids capable of using are tested, thereby perhaps can fluid 42 be combined to form the aliquot that will be delivered to analytical system 90 then with reagent from chamber 92 or other chambers;

(iv) can this sample or aliquot be sent to analytical system 90 then; Through taking these measures, cover 94 as manually knock bubble shape in a side of head 14, or the pushing button; Or moving switch, thereby sample or aliquot are got in the analytical system 90 and/or on;

(v) the diagnostic equipment 22 can show and/or appear (one or more) test result then; This result; For example can with on the diagnostic equipment 22 and/or the head 14 or in indicator change color form show; Perhaps can from the diagnostic equipment, take out test strip, or can and/or attract observation test bar in the storage 40 at head 14;

(vi) the head 14 and/or the diagnostic equipment 22 can discard then, and perhaps the head 14 and/or the diagnostic equipment 22 can be delivered to laboratory and carry out any other processing.

Aforementionedly should be regarded as only explaining principle of the present invention.In addition, because those skilled in the art expect many modifications and change easily, so do not expect to limit the invention to concrete structure and operation shown and description.Though described preferred implementation, can make change to details not departing under the situation of the present invention, the present invention is defined by the claims.

Claims (42)

1. one kind is used to send and/or removes fluidic device, and said device comprises:

Shell,

Be positioned at the irrigation storage of said shell, said irrigation storage is suitable for holding flush fluid,

Be positioned at the attractant storage of said shell, said attractant storage be suitable for holding attract fluid,

Barrier device is suitable for the liquid that is attracted is retained in the said attractant storage and gas can be flowed out from said attractant storage,

At least one nozzle that from said shell, stretches out; Said nozzle comprises irrigation inner chamber and attractant inner chamber; Said irrigation inner chamber is suitable for making fluid connection between said irrigation storage and the irrigation port; Said attractant inner chamber is suitable for providing the fluid between said attractant storage and the attractant port to be communicated with

Pumping installations, be suitable for making flush fluid pass through said irrigation inner chamber from said irrigation storage and from said irrigation port discharge and

Interface zone, said interface zone comprise at least one nonfluid stream unit and at least one air stream components.

2. device according to claim 1:

Wherein, said barrier device is positioned at said shell.

3. device according to claim 1

Wherein, said barrier device is positioned at said attractant storage.

4. according to each described device in the aforementioned claim:

Wherein, said barrier device comprises at least a in hydrophobic filter, foam, sponge, no filter structure, crisscross passage and the Cotton Gossypii.

5. according to each described device in the aforementioned claim

Further comprise heater, thereby said flush fluid is heated to predetermined temperature.

6. according to each described device in the aforementioned claim

Wherein, said shell comprises flexible portion, and said flexible portion is suitable for extruding or pushing, so that exert pressure to said irrigation storage directly or indirectly, and flush fluid is discharged from said irrigation storage.

7. according to each described device in the aforementioned claim

Further comprise and be used to test the fluidic diagnostic equipment that is attracted.

8. according to each described device in the aforementioned claim

Further comprise main body, said main body is suitable for being incorporated into releasedly said shell, and said main body comprises pumping installations, and said pumping installations is suitable for fluid through the said attractant port of said attractant inner chamber suction, and in the said attractant storage of suction.

9. according to each described device in the aforementioned claim

Said main body further comprises the controller that is suitable for controlling I & A.

10. according to each described device in the aforementioned claim, wherein, said pumping installations comprises twin-diaphragm pump.

11. according to each described device in the aforementioned claim

Wherein, said main body further comprises power source.

12. according to each described device in the aforementioned claim, wherein, said device have can be portable and operationally be held in size and the structure in user's hands.

13. according to each described device in the aforementioned claim

Wherein, said main body also comprises said interface zone, and said interface zone is suitable for said main body is incorporated into said shell.

14. according to each described device in the aforementioned claim

Wherein, said at least one nonfluid mobile parts comprises corrugated tube, thereby will put on said flushing storage from the power of said main body, so that flush fluid is discharged from said flushing storage.

15. according to each described device in the aforementioned claim

Wherein, said at least one air stream components comprises and makes gas flow into the path the said main body from said attraction storage.

16. according to each described device in the aforementioned claim

Wherein, said shell comprises removable and interchangeable head,

Further comprise main body, said main body is suitable for being incorporated into releasedly said shell, and said main body comprises said pumping installations, and

Wherein said interface zone is incorporated into said main body with said head.

17. according to each described device in the aforementioned claim

Wherein, at least one in said irrigation storage and the said attractant storage is removable and interchangeable.

18. according to each described device in the aforementioned claim

Wherein, said irrigation storage can recharge.

19. according to each described device in the aforementioned claim

Wherein, said interface zone comprises the sealing member between said head and the said main body,

Said sealing member is suitable for making the power that is applied on the said main body to transfer to said head, and

Said sealing member be suitable for making suction pressure from said main body with gas from the said main body of said attraction storage suction.

20. device according to claim 19

Wherein, the said power that is applied on the main body comprises the power that is applied on the control device, and the power that is applied on the said control device is transferred in the flushing storage in the said head through said sealing member.

21. device according to claim 20

Wherein, thus the said power that is applied on the said control device be suitable for activating suction pressure with gas from the said main body of said attraction storage suction.

30. the tool set that the device of I & A system is provided, said tool set comprises:

According to each described device in the aforementioned claim,

The operation instruction of the operation and the use of said device is described.

31. a handheld test device comprises:

Hand-held housing, said shell comprises head and base portion, said head and base portion are suitable for being bonded to each other releasedly at interface zone,

Be positioned at the attractant storage of said shell, said attractant storage be suitable for holding attract fluid,

Be positioned at the pumping installations of said shell, said pumping installations be suitable for in the said attractant storage of fluid suction and

Be used for test the attracts fluidic diagnostic equipment, the said diagnostic equipment that are positioned at said shell are suitable for providing fluidic indication as a result that test attracts.

32. device according to claim 31

The wherein said diagnostic equipment comprises at least a in test strip, electronic chip, chemicals and the hereditary test board.

33. according to each described device in the claim 31 to 32

Wherein, the said diagnostic equipment is included in the head.

34. according to each described device in the claim 31 to 33

Wherein, the said diagnostic equipment is suitable for providing test result.

35. according to each described device in the claim 31 to 34

Wherein, the said diagnostic equipment is contained in the said attractant storage.

36. according to each described device in the claim 31 to 35

Wherein, The said diagnostic equipment provides microorganism testing, comprises that influenza A and influenza B, bird flu, RSV (respiratory syncytial virus), adenovirus, Legionnella, CNV, EBV, A group beta hemolytic streptococcus, streptococcus pneumoniae, meningococcus, mycoplasma, staphylococcus aureus, malaria, HIV, rhinovirus, coccsackie virus, variola, anthrax, Botulinum toxin, Ricin, Ebola virus, rabies, brucellosis, (plague) Yersinia pestis, Coxiella burnetii (Q heat), T2 mycotoxin, soil draw hot Francisella (tularemia), viral equine encephalitis, viral hemorrhagic fever and burkholderia (glanders).

37. according to each described device in the claim 31 to 36

Wherein, The said diagnostic equipment provides toxicology and/or test chemical, comprises amphetamine, cocaine, opiate, phencyclidine, tetrahydrocannabinol, acetaminophen, barbiturate, benzene phenodiazine

class, methadone, third oxygen sweet smell, tricyclic anti-depressants, calcium channel blocker, ethanol, ethylene glycol, ketone, glucose, antidiabetic drug, cytokine, interleukin, insulin, HbA1 C, electrolyte, hCG's (pregnancy tests), thyrotropin (TSH), T3 blood test, T4 blood test, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).

38. according to each described device in the claim 31 to 17

Wherein, the said diagnostic equipment provides real-time polymerase chain reaction test and/or the immunoassay to virus, antibacterial and cancer.

39. a test set comprises:

Shell,

Be positioned at the attractant storage of said shell, said attractant storage be suitable for holding attract fluid and

Be used for the indication that test the attracts fluidic diagnostic equipment, the said diagnostic equipment are suitable for providing fluidic result that test attracts.

40. the tool set that the device of I & A system is provided, said tool set comprises:

According to each described device in the claim 31 to 39 and

The operation instruction of the operation and the use of said device is described.

41. a system that is used for the main body aperture is carried out I & A, said system comprises:

Head, said head are suitable for holding in the storage in flushing the flush fluid of scheduled volume, and said head comprise be suitable for holding scheduled volume attract fluidic attraction storage,

Main body, said main body are incorporated into said head releasedly and comprise the pumping installations in the said attraction storage of fluid suction,

Said system specialization about 200cc to the capacity of about 400cc, and have can be portable and operationally be held in size and the structure in user's hands, and

Said system is suitable for about 5, and 000cc/min is to about 20, and the speed of 000cc/min produces and gets into fluid volume.

42. according to the described system of claim 41:

Further be suitable for about 5,000cc/min is to about 20, and the speed of 000cc/min produces fluid volume, continues about 1 second to about 30 minutes time.

43. according to each described system in the claim 41 to 42

Comprise that further thereby power source provides power for said pumping installations.

44. according to each described system in the claim 41 to 43

Further be suitable for about 5 watts to about 15 watts power consumption with about 5,000cc/min is to about 20, the speed of 000cc/min produces fluid volume.

45. according to each described system in the claim 41 to 44

Wherein, said power source comprises the capacity of about 100mAh to about 1000mAh.

46. a system that is used for the main body aperture is carried out I & A, said system comprises:

Head, said head are suitable for holding in the storage in flushing the flush fluid of scheduled volume, and said head comprise be suitable for holding scheduled volume attract fluidic attraction storage,

Main body, said main body are incorporated into said head releasedly and comprise the pumping installations in the said attraction storage of fluid suction,

Said system specialization the capacity of about 200cc～about 400cc, have can be portable and operationally be held in size and the structure in user's hands, and

Said system is suitable for producing the suction pressure of about 50mmHg to about 200mmHg.

47. according to the described system of claim 46

Comprise that further thereby power source provides power for said pumping installations.

48. according to the described system of claim 47

Further be suitable for to about 15 watts power consumption, producing the suction pressure of about 50mmHg to about 200mmHg at about 5 watts.

49. one kind is used for system that the aperture is washed and/or attracted, said system comprises:

Washing capacity, attraction function and customer controller,

Said washing capacity comprises flushing ability and flushing storage; Said flushing storage is suitable for holding flush fluid; Said flushing ability is imported startup by the user in the washing capacity, thereby said flushing ability acts on said flushing storage flush fluid is entered the said aperture from said flushing storage

Said attraction function comprises suction pressure and attracts storage, and said attraction storage is suitable for catching institute and attracts fluid, said attraction storage to be suitable for institute's attraction fluid is retained in the said attraction storage and gas is flowed out from said attraction storage,

Said customer controller is suitable for providing at least one the control function in said washing capacity and the said attraction function, and the running of the running of said washing capacity and said attraction function is carried out off and on or carried out simultaneously,

The running of the running of said washing capacity and said attraction function has no interaction, and the running of the running of said attraction function and said washing capacity has no interaction.

50. a tool set comprises

According to each described system in the claim 41 to 49 and

The operation instruction of the operation and the use of said system is described.

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