CN102579009B - Electric signal processing unit for monitoring hydrocephalus and encephaledema - Google Patents
Electric signal processing unit for monitoring hydrocephalus and encephaledema Download PDFInfo
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- CN102579009B CN102579009B CN 201210045733 CN201210045733A CN102579009B CN 102579009 B CN102579009 B CN 102579009B CN 201210045733 CN201210045733 CN 201210045733 CN 201210045733 A CN201210045733 A CN 201210045733A CN 102579009 B CN102579009 B CN 102579009B
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Abstract
An electric signal processing unit for monitoring hydrocephalus and encephaledema comprises a receiving electrode, a signal-processing digital converter, an orthogonal regulator, a detector, a parameter evaluator, an impedance analyzer and an assessment instrument. Electromagnetic waves change after passing through a human brain, so that specific circumstances of the hydrocephalus and encephaledema can be evaluated by comparing attenuation coefficient (RAC), relative phase shift (RPS), propagation time difference (TTD) and complex wave value K of the electromagnetic waves before entering into the human brain and after passing through the human brain. According to the invention, electric signals are processed to calculate the parameter change value of the electromagnetic waves; and compared with the conventional invasive monitoring method, the electric signal processing unit is matched with a monitor and can realize 24-hour monitoring, so that medical security in treatment of the hydrocephalus and encephaledema is improved remarkably.
Description
Technical field
The present invention relates to a kind of signal processing apparatus of medical apparatus and instruments, particularly a kind of electric signal process unit of monitoring hydrocephalic medical apparatus and instruments.
Background technology
The condition that hydrocephalus is known is at encephalocoele or the ventricles of the brain, the excessive buildup of cerebrospinal fluid (CSF).Under normal circumstances, cerebrospinal fluid is that the running of brain is most important.Carry nutrient and refuse from brain, and create the neonychium of a liquid.But the excessive accumulation of cerebrospinal fluid is to the disproportionate pressure of brain, and may cause brain cell and tissue injury.Therefore, medical condition, the absorption of directly interrupting cerebrospinal fluid enters the proper flow of blood and creates cerebrospinal fluid too much, finally causes hydrocephalus.
Human potential and classification that hydrocephalus affects institute's has age can be divided into two large classes: obtain congenital hydrocephalus and the day after tomorrow hydrops.Congenital hydrocephalus is when birth, can be in the gene unconventionality of the growth and development stage of fetus, premature labor, or the result of impact.By contrast, obtaining hydrops the day after tomorrow is that some body reason pathological changes of people causes, but is not limited only to angiopathy, injury of head or injury of head.Cause adult's apoplexy, hemorrhage, or the hydrops of these two categories of brain trauma, be called as ultravacuum hydrocephalus and normal pressure hydrocephalus (NPH).
Although hydrocephalus citizen situation is not registered by country, the data that draw after by the assessment to some are significant to the assessment of national population.The institute of NIH's neurological disorders and apoplexy branch estimates, approximately just have among per 500 children 1 congenital ill.And nearest statistical data shows, NPH is exactly the origin of dementia, and 5% people suffers from dementia among patient NPH more than 70 years old.
During the diagnosis hydrocephalus, most of doctors utilize Cranial Computed Tomography or MRI scanning.On the other hand, monitoring technology mainly comprises invasive method at present, and such as monitoring intracranial pressure, waist is worn (LP), or uses electrode insertion measurement cerebrospinal fluid impedance in cerebrospinal fluid.In these programs, a hole is essential, and with assessment intracranial environment, LP can cause that cerebral hernia is dead sometimes.Recently, developed the hydrocephalic technology of non-invasive assessment based on the TCD,transcranial Doppler (TCS) of medical supersonic technology, but said method does not all provide 24 hours bedside monitorings.
Another similar situation, hydrocephalus, cerebral edema.The cerebral edema brain injury, wound and infection etc., may cause similar we ankle or knee injury after expand with unnecessary moisture from cerebral tissue swelling.Yet unlike our ankle or knee, our brain is to surround thick and hard skull, does not leave enough expansion leeway, thereby causes intracranial pressure to increase.If None-identified and undressed, cerebral edema can cause nonvolatil injury or death., in intensive care unit(ICU) continuous monitoring hydrocephalus 24 hours every days and cerebral edema, this is desirable method and system at patient's bedside.This system needs cost low, is easy to use, and allows automatically monitoring and minimum of interference.
Summary of the invention
Purpose of the present invention just provides a kind of electric signal process unit for monitor cerebral hydrops and cerebral edema, it can be processed the signal of telecommunication that passes through human brain that monitoring device collects, it can use 24 hours monitoring and evaluation hydrocephaluss of mode of non-invasion and the situation of cerebral edema to cooperate monitoring device, reduces Operative risk.
The objective of the invention is to realize by such technical scheme, it includes collecting electrode, signal processing digital converter, Orthogonal modification device, detector, parameter evaluation device, electric impedance analyzer and assessment instrument,
Collecting electrode receives the electromagnetic wave that the emission electrode by human brain sends;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, is digital signal with analog signal conversion again;
The Orthogonal modification device, the signal of telecommunication orthogonalization process to the signal processing digitizer processes is crossed obtains in the same way signal
And orthogonal signalling
Detector detects electromagnetic in the same way signal
And orthogonal signalling
The parameter evaluation device calculates relative damping coefficient
, relative phase shift
, propagation time difference
With complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment instrument carries out hydrocephalus and cerebral edema assessment according to the parameter that parameter evaluation device and electric impedance analyzer obtain.
Further, described signal processing converter includes amplification module, the first demodulation module, the second demodulation module, buffer module and digital module,
Amplification module amplifies the signal of telecommunication that receives by low noise and wideband difference amplifier;
The first demodulation module carries out demodulation in frequency range 0 to 50MHZ to the signal of telecommunication after amplifying;
The second demodulation module carries out demodulation in frequency range 50 to 400MHZ to the signal of telecommunication after amplifying;
Buffer module is for the output signal of buffering the first demodulation module;
Digital module is sampled the signal of telecommunication after the demodulation and digitized processing.
Further, the chip used model of described amplification module is LMH6552.
Further, the chip used model of described the first demodulation module is AD8333.
Further, the chip used model of described the second demodulation module is AD8348.
Further, the chip used model of described buffer module is LTC2061.
Further, the chip used model of described digital module is dsPIC33F.
Further, the parameter evaluation device passes through following formula to attenuation quotient
Calculate
In the formula
Be propagation distance,
Be the electromagnetic empty ripple that receives,
Be the electromagnetic empty ripple of emission,
Be the electromagnetic wave angular frequency.
Further, the parameter evaluation device passes through following formula to relative phase shift
Calculate
In the formula
Be propagation distance,
Be the electromagnetic phase place that receives,
Be the electromagnetic phase place of emission,
Be the electromagnetic wave angular frequency.
Further, the parameter evaluation device passes through following formula to propagation time difference
Calculate
In the formula,
Be the electromagnetic wave propagation speed that receives,
Electromagnetic wave propagation speed for emission.
Owing to having adopted technique scheme, the present invention has advantages of as follows:
Change has occured by behind the human brain in electromagnetic wave, by the attenuation quotient after relatively electromagnetic wave enters human brain before and passes through human brain
, relative phase shift
, propagation time difference
With complex wave value K, can assess the concrete condition of hydrocephalus and cerebral edema.The present invention calculates electromagnetic parameter change value by the processing to the signal of telecommunication, cooperates monitoring device, is different from the traditional invasive monitoring method, can realize monitoring in 24 hours, has significantly increased the medical safety of hydrocephalus and cerebral edema.
Other advantages of the present invention, target and feature will be set forth to a certain extent in the following description, and to a certain extent, based on being apparent to those skilled in the art to investigating hereinafter, perhaps can be instructed from the practice of the present invention.Target of the present invention and other advantages can realize and obtain by following description and claims.
Description of drawings
Description of drawings of the present invention is as follows.
Fig. 1 is structural representation of the present invention.
The specific embodiment
The invention will be further described below in conjunction with drawings and Examples.
Be used for the electric signal process unit of monitor cerebral hydrops and cerebral edema, it is characterized in that: described device includes collecting electrode, signal processing digital converter, Orthogonal modification device, detector, parameter evaluation device, electric impedance analyzer and assessment instrument,
Collecting electrode receives the electromagnetic wave that the emission electrode by human brain sends;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, is digital signal with analog signal conversion again;
The Orthogonal modification device, the signal of telecommunication orthogonalization process to the signal processing digitizer processes is crossed obtains in the same way signal
And orthogonal signalling
Detector detects electromagnetic in the same way signal
And orthogonal signalling
The parameter evaluation device calculates relative damping coefficient
, relative phase shift
, propagation time difference
With complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment instrument carries out hydrocephalus and cerebral edema assessment according to the parameter that parameter evaluation device and electric impedance analyzer obtain.
Electromagnetic wave changes by human brain, and collecting electrode of the present invention receives the electromagnetic wave after the change, and amplification and Filtering Processing by the signal processing digital converter convert digital signal again to.Digital signal is regulated through the Orthogonal modification device, detects by the electromagnetic parameter behind the human brain by detector again, and the parameter that the combined impedance analyser obtains is carried out the assessment of hydrocephalus and cerebral edema.
By the resulting change of the propagation of electromagnetic wave in human brain, the principle that hydrocephalus and cerebral edema are assessed is: the dielectric constant that cerebrospinal fluid, alba and ectocinerea are different in the human brain and conductivity, the electric conductivity of cerebrospinal fluid does not have than alba and ectocinerea, the electric medium constant of cerebrospinal fluid is lower than alba and ectocinerea, electromagnetic wave propagation is relevant with dielectric constant and conductivity, can distinguish cerebrospinal fluid in the human brain by electromagnetic change, thereby be used for estimating the content of cerebrospinal fluid, carry out the assessment of hydrocephalus and brain water kind.Device of the present invention is non-invasion formula, and it is subcutaneous that emission electrode and collecting electrode only need be positioned at brain.
The present invention can assess the concrete condition of hydrocephalus and cerebral edema by above-mentioned work, be different from the traditional invasive monitoring method, and the present invention can realize monitoring in 24 hours, has significantly increased the medical safety of hydrocephalus and cerebral edema.Its electromagnetic wave parameter circular is: the parameter evaluation device passes through following formula to attenuation quotient
Calculate
In the formula
Be propagation distance,
Be the electromagnetic empty ripple that receives,
Be the electromagnetic empty ripple of emission,
Be the electromagnetic wave angular frequency.
The parameter evaluation device passes through following formula to relative phase shift
Calculate
In the formula
Be propagation distance,
Be the electromagnetic phase place that receives,
Be the electromagnetic phase place of emission,
Be the electromagnetic wave angular frequency.
The parameter evaluation device passes through following formula to propagation time difference
Calculate
In the formula,
Be the electromagnetic wave propagation speed that receives,
Electromagnetic wave propagation speed for emission.
Described signal processing converter includes amplification module, the first demodulation module, the second demodulation module, buffer module and digital module,
Amplification module amplifies the signal of telecommunication that receives by low noise and wideband difference amplifier;
The first demodulation module carries out demodulation in frequency range 0 to 50MHZ to the signal of telecommunication after amplifying;
The second demodulation module carries out demodulation in frequency range 50 to 400MHZ to the signal of telecommunication after amplifying;
Buffer module is for the output signal of buffering the first demodulation module;
Digital module is sampled the signal of telecommunication after the demodulation and digitized processing.
Electromagnetic wave is propagated and will be received by electrode by brain, is amplified by low noise and wideband difference amplifier LMH6552.Amplifier signal is the first demodulator AD8333 institute demodulation of 0-50 MHz by frequency range, then be the second demodulator AD8348 institute demodulation of 50 MHz-400 MHz by frequency range, buffer LTC 2061 is used to cushion the output of the first demodulator AD8333.Two pairs come from the orthogonal signalling I of two different frequency scopes and in the same way signal Q be digitized module dsPIC33F digitized.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can make amendment or be equal to replacement technical scheme of the present invention, and not breaking away from aim and the scope of the technical program, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (10)
1. be used for the electric signal process unit of monitor cerebral hydrops and cerebral edema, it is characterized in that: described device includes collecting electrode, signal processing digital converter, Orthogonal modification device, detector, parameter evaluation device, electric impedance analyzer and assessment instrument,
Collecting electrode receives the electromagnetic wave that the emission electrode by human brain sends;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, is digital signal with analog signal conversion again;
The Orthogonal modification device, the described digital signal orthogonalization process to obtaining after the signal processing digitizer processes obtains in the same way signal
And orthogonal signalling
Detector detects electromagnetic in the same way signal
And orthogonal signalling
The parameter evaluation device calculates relative damping coefficient
, relative phase shift
, propagation time difference
With complex wave value K;
Electric impedance analyzer according to the described digital signal that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment instrument carries out hydrocephalus and cerebral edema assessment according to the parameter that parameter evaluation device and electric impedance analyzer obtain.
2. the electric signal process unit for monitor cerebral hydrops and cerebral edema as claimed in claim 1, it is characterized in that: described signal processing digital converter includes amplification module, the first demodulation module, the second demodulation module, buffer module and digital module
Amplification module amplifies the signal of telecommunication that receives by low noise and wideband difference amplifier;
The first demodulation module carries out demodulation in frequency range 0 to 50MHZ to the signal of telecommunication after amplifying;
The second demodulation module carries out demodulation in frequency range 50 to 400MHZ to the signal of telecommunication after amplifying;
Buffer module is for the output signal of buffering the first demodulation module;
Digital module is sampled the signal of telecommunication after the demodulation and digitized processing.
3. the electric signal process unit for monitor cerebral hydrops and cerebral edema as claimed in claim 2, it is characterized in that: the chip used model of described amplification module is LMH6552.
4. the electric signal process unit for monitor cerebral hydrops and cerebral edema as claimed in claim 2, it is characterized in that: the chip used model of described the first demodulation module is AD8333.
5. the electric signal process unit for monitor cerebral hydrops and cerebral edema as claimed in claim 2, it is characterized in that: the chip used model of described the second demodulation module is AD8348.
6. the electric signal process unit for monitor cerebral hydrops and cerebral edema as claimed in claim 2, it is characterized in that: the chip used model of described buffer module is LTC2061.
7. the electric signal process unit for monitor cerebral hydrops and cerebral edema as claimed in claim 2, it is characterized in that: the chip used model of described digital module is dsPIC33F.
8. such as claim 1,2,3,4,5,6 or 7 described electric signal process units for monitor cerebral hydrops and cerebral edema, it is characterized in that: the parameter evaluation device passes through following formula to attenuation quotient
Calculate
In the formula
Be propagation distance,
Be the electromagnetic empty ripple that receives,
Be the electromagnetic empty ripple of emission,
Be the electromagnetic wave angular frequency.
9. such as claim 1,2,3,4,5,6 or 7 described electric signal process units for monitor cerebral hydrops and cerebral edema, it is characterized in that: the parameter evaluation device passes through following formula to relative phase shift
Calculate
In the formula
Be propagation distance,
Be the electromagnetic phase place that receives,
Be the electromagnetic phase place of emission,
Be the electromagnetic wave angular frequency.
10. such as claim 1,2,3,4,5,6 or 7 described electric signal process units for monitor cerebral hydrops and cerebral edema, it is characterized in that: the parameter evaluation device passes through following formula to propagation time difference
Calculate
In the formula,
Be the electromagnetic wave propagation speed that receives,
Electromagnetic wave propagation speed for emission.
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| CN103110408A (en) * | 2013-03-14 | 2013-05-22 | 重庆大学 | Encephaledema monitoring device |
| CN104783794A (en) * | 2015-04-15 | 2015-07-22 | 重庆博恩富克医疗设备有限公司 | Method and device for processing electromagnetic wave signals |
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| CN1419889A (en) * | 2002-07-24 | 2003-05-28 | 重庆博恩科技有限公司 | Method for non-invasive clinical monitoring intracranial edema |
| CN1714746A (en) * | 2005-07-14 | 2006-01-04 | 中国人民解放军第四军医大学 | Non-contact magnetic inductive encephaledema monitoring method |
| CN101849818A (en) * | 2010-06-03 | 2010-10-06 | 中国人民解放军第三军医大学 | Device for checking type of cerebral edema |
| CN202477660U (en) * | 2012-02-27 | 2012-10-10 | 重庆博恩富克医疗设备有限公司 | Electrical signal processing device for monitoring hydrocephalus and encephaledema |
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Patent Citations (6)
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| US4690149A (en) * | 1985-10-28 | 1987-09-01 | The Johns Hopkins University | Non-invasive electromagnetic technique for monitoring physiological changes in the brain |
| US6233479B1 (en) * | 1998-09-15 | 2001-05-15 | The Regents Of The University Of California | Microwave hematoma detector |
| CN1419889A (en) * | 2002-07-24 | 2003-05-28 | 重庆博恩科技有限公司 | Method for non-invasive clinical monitoring intracranial edema |
| CN1714746A (en) * | 2005-07-14 | 2006-01-04 | 中国人民解放军第四军医大学 | Non-contact magnetic inductive encephaledema monitoring method |
| CN101849818A (en) * | 2010-06-03 | 2010-10-06 | 中国人民解放军第三军医大学 | Device for checking type of cerebral edema |
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