CN102527132A - Fine particle separator - Google Patents

Fine particle separator Download PDF

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Publication number
CN102527132A
CN102527132A CN2011103653843A CN201110365384A CN102527132A CN 102527132 A CN102527132 A CN 102527132A CN 2011103653843 A CN2011103653843 A CN 2011103653843A CN 201110365384 A CN201110365384 A CN 201110365384A CN 102527132 A CN102527132 A CN 102527132A
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CN
China
Prior art keywords
fine particle
stream
filter
separating device
piezoelectric element
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Pending
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CN2011103653843A
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Chinese (zh)
Inventor
八木浩
吉冈佐登美
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Seiko Epson Corp
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Seiko Epson Corp
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Publication of CN102527132A publication Critical patent/CN102527132A/en
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D29/00Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/62Regenerating the filter material in the filter
    • B01D29/70Regenerating the filter material in the filter by forces created by movement of the filter element
    • B01D29/72Regenerating the filter material in the filter by forces created by movement of the filter element involving vibrations

Abstract

The invention provides a fine particle separator that can reduce filter clogging. The fine particle separator includes a channel having an inlet; a chamber; a filter that is in communication with the channel and the chamber; and a piezoelectric element that vibrates the filter. The piezoelectric element may be provided on the channel forming member, and may vibrate the filter via the channel forming member. The channel may include an outlet. With the piezoelectric element directly or indirectly vibrating the filter, particles or a solid phase can be suppressed from adhering to the filter, and from closing the through holes of the filter. As a result, clogging can be reduced.

Description

Fine particle separating device
The application advocates No.2010-258639 number the priority of on November 19th, 2010 in japanese publication, and quotes its full content at this.
Technical field
The present invention relates to fine particle separating device.
Background technology
Known fine particle separating device with filter, this filter are used for being dispersed with the dispersion liquid of solids from the muddy liquid of liquid phase and solid phase or at liquid, isolate the solid phase or the solids of expectation.For the fine particle separating device with filter, the mesh that produces filter through the use meeting stops up, and therefore need be able to reduce the fine particle separating device of the mesh obstruction of filter.
As the technology that the mesh that is used to reduce filter stops up, in japanese kokai publication hei 6-269274 communique, put down in writing and had the structure that makes the mechanical type exciting agency of porous matter screen pack (filter) vibration by axle.And, in TOHKEMY 2001-15465 communique, put down in writing structure, thereby this ultrasonic type exciting agency makes the filter vibration through utilizing ultrasonic unit to liquid irradiation ultrasonic wave with ultrasonic type exciting agency.
Yet mechanical type exciting agency and ultrasonic type exciting agency all are difficult to realize miniaturization.And, in the ultrasonic type exciting agency, owing to form from apart from filter place far away exciting indirectly, so efficiency is lower.And then, in the ultrasonic type exciting agency, under the situation of handling small particle such as cell as particulate, exist small particles such as vibration meeting pair cell to cause the such problem of bigger damage.
Summary of the invention
The present invention accomplishes in view of the problem points of above that kind, according to several kinds of modes of the present invention, the fine particle separating device of the mesh obstruction that can reduce filter can be provided.
(1) the related fine particle separating device of this mode comprises: the piezoelectric element that has stream, room, the filter that is communicated with said stream and said room of inlet and make said filter vibration.
According to this mode, owing to utilize piezoelectric element to make the filter vibration, therefore compare with the situation of the situation of using the mechanical type exciting agency or use ultrasonic type exciting agency, can make the fine particle separating device miniaturization.Compare with the situation of using the ultrasonic type exciting agency in addition, can piezoelectric element be arranged near the filter that becomes the exciting object.Therefore, compare, can reduce mesh with the vibration of little energy and stop up with the situation of using the ultrasonic type exciting agency.And, stop up owing to can reduce eyelet with the vibration of little energy, therefore under the situation of handling small particle such as cell as particulate, compare with the ultrasonic type exciting agency, can reduce to vibrate the damage that small particle such as pair cell causes.
(2) this fine particle separating device can also comprise that the stream that forms said stream forms parts, and said piezoelectric element is arranged at said stream and forms parts, and makes said filter vibration via said stream formation parts.
Thus, be utilized on the stream formation parts the so simple operation of piezoelectric element is set, can make the fine particle separating device that can make the filter vibration.
(3) this fine particle separating device can also comprise through the part with said piezoelectric element and is connected the support that supports said piezoelectric element with the internal face of said stream, and said piezoelectric element is arranged in the said stream.
Thus, because the part of piezoelectric element is supported, therefore compare, reduce the bound part of piezoelectric element, thereby improve vibration efficiency with the situation that integral body to piezoelectric element supports.And,, therefore need not to form parts, but just can make the filter vibration via flowing liquid in stream via stream because the piezoelectric element portion of being supported is supported on the inboard of stream.The mesh that therefore, can reduce filter with the vibration of littler energy stops up.
(4) in this fine particle separating device, said piezoelectric element can join with said filter and be arranged in the said stream.
Thus, can directly make the filter vibration by piezoelectric element.Therefore can reduce mesh with the vibration of little energy stops up.
(5) the related fine particle separating device of this mode comprises: have stream, the room of inlet and constitute the filter that is communicated with and comprises piezoelectric element with said stream and said room.
According to this mode, filter constitutes and comprises piezoelectric element, and filter self can vibrate thus.Therefore can reduce mesh with the vibration of little energy stops up.
(6) in this fine particle separating device, said stream can have outlet.
Thus, can discharge not particle from outlet through filter.Therefore can reduce mesh stops up.
Description of drawings
Fig. 1 (A) is the vertical view of the related fine particle separating device 1 of schematically illustrated first embodiment, and Fig. 1 (B) is the cutaway view of the A-A line of Fig. 1 (A).
Fig. 2 (A) is the vertical view of the related fine particle separating device 2 of schematically illustrated second embodiment, and Fig. 2 (B) is the cutaway view of the A-A line of Fig. 2 (A).
Fig. 3 (A) is the vertical view of the related fine particle separating device 3 of schematically illustrated the 3rd embodiment, and Fig. 3 (B) is the cutaway view of the A-A line of Fig. 3 (A).
Fig. 4 (A) is the vertical view of the related fine particle separating device 4 of schematically illustrated the 4th embodiment, and Fig. 4 (B) is the cutaway view of the A-A line of Fig. 4 (A).
Fig. 5 (A) is the vertical view of the related fine particle separating device 3a of the variation of schematically illustrated the 3rd embodiment, and Fig. 5 (B) is the cutaway view of the B-B line of Fig. 5 (A).
Fig. 6 (A) is the vertical view of the related fine particle separating device 4a of the variation of schematically illustrated the 4th embodiment, and Fig. 6 (B) is the cutaway view of the B-B line of Fig. 6 (A).
Fig. 7 (A) is the vertical view of the related fine particle separating device 4b of other variation of schematically illustrated the 4th embodiment, and Fig. 7 (B) is the cutaway view of the A-A line of Fig. 7 (A).
Fig. 8 (A) is the vertical view of the related fine particle separating device 4c of other variation of schematically illustrated the 4th embodiment, and Fig. 8 (B) is the cutaway view of the A-A line of Fig. 8 (A).
Fig. 9 is used for block diagram that the separation of particles system 100 that has used the related fine particle separating device 1 of first embodiment is described.
Figure 10 is used for the block diagram that the 100a of separation of particles system to the related fine particle separating device 4b of the variation of having used the 4th embodiment describes.
Figure 11 is used for the block diagram that the 100b of separation of particles system to the related fine particle separating device 4c of the variation of having used the 4th embodiment describes.
1,2,3,3a, 4,4a, 4b, 4c... fine particle separating device drawing reference numeral explanation:; 10... stream; 12... inlet; 14... outlet; 20... room; 22... inlet; 24... outlet; 30,32... filter; 40... piezoelectric element; 50... stream forms parts; 60... support; 100,100a, 100b... separation of particles system; 110... particle dispersion liquid is used container; 112... pump; 114,116... returnable; 118... auxiliary liquid is used container; 120... pump; 150... control part.
The specific embodiment
Below, utilize accompanying drawing preferred embodiment to be elaborated to of the present invention.In addition, illustrated embodiment below is not that the content of the present invention that claims are put down in writing limits improperly.And below illustrated structure whole be not necessarily structure important document essential to the invention.
1. the related fine particle separating device of first embodiment
Fig. 1 (A) is the vertical view of the related fine particle separating device 1 of schematically illustrated first embodiment, and Fig. 1 (B) is the cutaway view of the A-A line of Fig. 1 (A).
The related fine particle separating device 1 of this embodiment comprises: the piezoelectric element 40 that has stream 10, room 20, the filter 30 that is communicated with stream 10 and room 20 of inlet 12 and make filter 30 vibrations.
Stream 10 comprises that feed flow reaches the muddy liquid of solid phase mutually or in liquid, is dispersed with the inlet 12 that the dispersion liquid of solids imports.That is, stream 10 12 flows to the stream of filter 30 and plays a role as being used for waiting for liquid from entering the mouth.
And stream 10 can comprise the muddy liquid of feed flow phase and solid phase or in liquid, be dispersed with the outlet 14 of the dispersion liquid discharge of solids.That is, stream 10 can 12 flow to the stream of outlet 14 and plays a role as being used for waiting for liquid from entering the mouth.Thus, can be with not discharging from exporting 14 through the particle and the solid phase of filter 30.Therefore can reduce mesh stops up.And can discharge particle and the solid phase of not passing through filter 30.
The shape in the cross section of the stream 10 that the flow direction of the liquid from stream 10 is observed is not done particular determination, for example can form rectangle.And from entering the mouth 12 to can be identical between the outlet 14, also can there be different at different position and different in the shape in the cross section of the stream 10 that the flow direction of the liquid from stream 10 is observed.
Room 20 is communicated with stream 10 via filter 30.Room 20 can comprise the outlet 24 of discharging for liquid.The shape of room 20 is not done particular determination, can form shape arbitrarily according to purpose.In the example shown in Fig. 1 (A) and Fig. 1 (B),, therefore constitute as flowing through the stream of the liquid flow that comes from stream 10 via filter 30 and playing a role because room 20 comprises outlet 24.
Filter 30 is communicated with stream 10 and room 20.That is, in the example shown in Fig. 1 (A) and Fig. 1 (B), the inlet 12 that room 20 is configured in than stream 10 more leans on the downstream.That is, liquid flows into room 20 from stream 10 via filter 30.Filter 30 has and is used for the through hole that is communicated with stream 10 and room 20.The shape of the opening of stream 10 sides of the through hole that filter 30 is had and the opening of room 20 sides can be taked shape arbitrarily.In the example shown in Fig. 1 (A), the opening of stream 10 sides of the through hole that filter 30 is had and the opening of room 20 sides be shaped as circle.The size of the opening of stream 10 sides of the through hole that filter 30 is had and the opening of room 20 sides can be utilized the size of particle that fine particle separating device 1 separates and solid phase and suitably sets according to desire.For example; Carry out the composition blood sampling and from blood constituent, take out under the situation of monocyte at tip blood the people; Because the diameter of common monocyte is about 13 μ m~20 μ m; Therefore the diameter of the opening of the opening of stream 10 sides of the through hole that had of filter 30 and room 20 sides can be 50%~80% promptly to the scope below the 16.8 μ m, to select more than the 6.5 μ m from the diameter with respect to common monocyte.Under the situation that the diameter of opening has been selected the less value, can improve the precision of separating monocyte in above-mentioned scope.Under the situation that the diameter of opening has been selected the bigger value in above-mentioned scope, can guarantee the amount of accessible liquid of unit interval, and can monocyte be separated to stream 10 sides.
Fine particle separating device 1 can comprise that the stream that is used to form stream 10 forms parts 50.The material that forms the parts of stream 10, room 20 and filter 30 is not done particular determination; For example; Through with resin injection molding, or MEMS (Micro Electro Mechanical Systems) technology is used for semiconductor substrate, glass substrate, organic material substrate etc., can make the related fine particle separating device of first embodiment 1.In addition, for example the substrate through will being formed with groove or form the combination that porose substrate suits also can be made the related fine particle separating device of first embodiment 1.
Piezoelectric element 40 makes filter 30 vibrations.In the example shown in Fig. 1 (A) and Fig. 1 (B), piezoelectric element 40 is through forming flowing liquid in parts 50 and the stream 10 and make filter 30 vibrations indirectly at stream.Vibration action based on piezoelectric element 40 can be carried out all the time, also can carry out discontinuously.The vibrational waveform of piezoelectric element 40 is not done particular determination, for example, can be sine wave or square wave of assigned frequency etc., can be time dependent sine wave of frequency or square wave etc. yet.Can adopt known various structure as piezoelectric element 40, for example, can use with the capacitive piezoelectric element of two electrodes from the clamping piezoelectrics that get off of thickness direction.Such piezoelectric element 40 for example can utilize membrane process manufacturing.Also can use the high material of insulating properties to apply piezoelectric element 40.
Piezoelectric element 40 can be arranged at stream and form parts 50, and makes filter 30 vibrations through stream formation parts 50.For example, piezoelectric element 40 can utilize adhesives etc. bonding and be arranged on it and stream forms on the interface of parts 50.
In the example shown in Fig. 1 (A) and Fig. 1 (B), piezoelectric element 40 is arranged at the part of not facing stream 10 that stream forms parts 50.That is, piezoelectric element 40 form parts 50 through stream and in stream 10 flowing liquid make filter 30 vibrations.And; In the example shown in Fig. 1 (A) and Fig. 1 (B); Piezoelectric element 40 is arranged on the zone that comprises following part, that is: stream forms the area of space superposed part behind not the prolonging in the face of the part of stream 10 and with through hole that hypothesis is had filter 30 of parts 50.Thus, because the vibration of piezoelectric element 40 can be delivered to the through hole that filter 30 is had effectively, the mesh that therefore can reduce filter 30 with the vibration of little energy stops up.
Piezoelectric element 40 also can be arranged on the zone that comprises following part, that is: stream forms the area of space superposed part behind the prolonging in the face of the part of stream 10 and with through hole that hypothesis is had filter 30 of parts 50.In this case, because piezoelectric element 40 is arranged in the stream 10, the mesh that therefore can reduce filter 30 with the vibration of littler energy stops up.In addition, under the situation in piezoelectric element 40 is arranged at stream 10, preferably, with flexibility and insulating properties and can not bring dysgenic material coating piezoelectric element 40 to the liquid that is directed to stream 10 or particle etc. with appropriateness.For example, be to contain under the situation of liquid of blood constituent at the liquid that is directed to stream 10, as the material that in the coating of piezoelectric element 40, uses, can give an example out for example polystyrene, Merlon, allyl resin etc.
The fine particle separating device 1 related according to first embodiment; Make filter 30 vibrations directly or indirectly through piezoelectric element 40; Can suppress particle or solid phase thus and be adhered to filter 30, and can suppress the through hole of particle or solid phase embedding filter 30.Therefore, can reduce mesh stops up.
And, because the related fine particle separating device 1 of first embodiment utilizes piezoelectric element 40 to make filter 30 vibrations, therefore compare with the situation of the situation of using the mechanical type exciting agency or use ultrasonic type exciting agency, can make the exciting agency miniaturization.
And then, to compare with the situation of using the ultrasonic type exciting agency, the related fine particle separating device 1 of first embodiment can be arranged on piezoelectric element 40 near the filter 30 that becomes the exciting object.Therefore compare with the situation of using the ultrasonic type exciting agency and can reduce the mesh obstruction with the vibration of little energy.And, stop up owing to can reduce mesh with the vibration of little energy, therefore under the situation of handling small particle such as cell as particulate, compare with the ultrasonic type exciting agency, can reduce to vibrate the damage that small particle such as pair cell causes.
And, because being arranged at stream with piezoelectric element 40, the related fine particle separating device 1 of first embodiment forms parts 50, therefore can enough simple methods make.
In the explanation of the embodiment of after this being put down in writing, variation and application examples,, and omit its detailed description to the identical label of structure division mark identical with first embodiment.
2. the related fine particle separating device of second embodiment
Fig. 2 (A) is the vertical view of the related fine particle separating device 2 of schematically illustrated second embodiment, and Fig. 2 (B) is the cutaway view of the A-A line of Fig. 2 (A).
The related fine particle separating device 2 of second embodiment comprises support 60, and this support 60 is connected with the internal face of stream 10 through the part with piezoelectric element 40 and piezoelectric element is supported, and piezoelectric element 40 is arranged in the stream 10.
In the example shown in Fig. 2 (A) and Fig. 2 (B), support 60 constitutes through being connected and piezoelectric element 40 is supported forming parts 50 with the stream of the internal face that becomes stream 10 near the end of the length direction of piezoelectric element 40.Preferably, the material that support 60 usefulness absorption of vibrations property are high constitutes.As such material, the for example rubber type of material (elastomeric material etc.) of can giving an example out.
In the example shown in Fig. 2 (A) and Fig. 2 (B), near the mode that is supported portion's 60 supportings the end of piezoelectric element 40 with its length direction is arranged in the stream 10.Be adhered to the situation that stream forms parts 50 with the integral body of piezoelectric element 40 thus and compare, can reduce piezoelectric element 40 bound parts, thereby improve vibration efficiency.And piezoelectric element 40 need not to form parts 50 through stream, but makes filter 30 vibrations through flowing liquid in stream 10.The mesh that therefore can reduce filter 30 with the vibration of littler energy stops up.
3. the related fine particle separating device of the 3rd embodiment
Fig. 3 (A) is the vertical view of the related fine particle separating device 3 of schematically illustrated the 3rd embodiment, and Fig. 3 (B) is the cutaway view of the A-A line of Fig. 3 (A).
The related fine particle separating device 3 of the 3rd embodiment joins piezoelectric element 40 and filter 30 and is arranged in the stream 10.In the example shown in Fig. 3 (A) and Fig. 3 (B), piezoelectric element 40 is configured to range upon range of and is adhered to stream 10 sides of filter 30.And in the example shown in Fig. 3 (A) and Fig. 3 (B), piezoelectric element 40 is provided with the through hole that the through hole that had with filter 30 is communicated with.
The related fine particle separating device 3 of the 3rd embodiment can directly make filter 30 vibrations by piezoelectric element 40.Therefore can reduce mesh with the vibration of littler energy stops up.
And the related fine particle separating device of the 3rd embodiment 3 is can be enough range upon range of and be adhered to simple method such as filter 30 and make with piezoelectric element 40.In addition, though in the 3rd embodiment, illustrated piezoelectric element 40 is range upon range of and be adhered to the example of stream 10 sides of filter 30, also can be range upon range of and be adhered to room 20 sides of filter 30 with piezoelectric element 40.
4. the related fine particle separating device of the 4th embodiment
Fig. 4 (A) is the vertical view of the related fine particle separating device 4 of schematically illustrated the 4th embodiment, and Fig. 4 (B) is the cutaway view of the A-A line of Fig. 4 (A).
The related fine particle separating device 4 of the 4th embodiment comprises: have inlet 12 stream 10, room 20, constitute the filter 32 that is communicated with and comprises piezoelectric element with stream 10 and room 20.
In the example shown in Fig. 4 (A) and Fig. 4 (B), filter 32 is made up of piezoelectric element.That is, filter 32 is made up of the piezoelectric element with through hole that stream 10 is communicated with room 20.
The fine particle separating device 4 related according to the 4th embodiment, because filter 32 constitutes and comprises piezoelectric element, filter 32 can vibrate self thus.Therefore can reduce mesh with the vibration of littler energy stops up.
5. variation
Fig. 5 (A) is the vertical view of the related fine particle separating device 3a of the variation of schematically illustrated the 3rd embodiment, and Fig. 5 (B) is the cutaway view of the B-B line of Fig. 5 (A).
In the example shown in Fig. 5 (A) and Fig. 5 (B); The shape of the opening of stream 10 sides of the through hole that filter 30 is had and the opening of room 20 sides is with the slit-shaped of following direction as length direction, and this direction is meant: liquid under 12 situation about being imported into that enter the mouth liquid from 12 directions that flow to outlet 14 that enter the mouth.The slit width of the opening of stream 10 sides of the through hole that filter 30 is had and the opening of room 20 sides, the setting that can utilize the size of the particle that fine particle separating device 3a separates to suit according to desire.For example; Carry out the composition blood sampling and from blood constituent, take out under the situation of monocyte at tip blood the people; Because the diameter of common monocyte is about 13 μ m~20 μ m; Therefore the slit width of the opening of the opening of stream 10 sides of the through hole that had of filter 30 and room 20 sides can be 50%~80% promptly to the scope below the 16.8 μ m, to select more than the 6.5 μ m from the diameter with respect to common monocyte.Under the situation that slit width has been selected the less value, can improve the precision of separating monocyte in above-mentioned scope.Under the situation that slit width has been selected the bigger value in above-mentioned scope, can guarantee the amount of the liquid that the unit interval can handle, and can monocyte be separated to stream 10 sides.
In addition, the filter with slit-shaped openings 30 shown in Fig. 5 (A) and Fig. 5 (B) is suitable in the related fine particle separating device 2 of the related fine particle separating device 1 of first embodiment and second embodiment too.
Fig. 6 (A) is the vertical view of the related fine particle separating device 4a of the variation of schematically illustrated the 4th embodiment, and Fig. 6 (B) is the cutaway view of the B-B line of Fig. 6 (A).
In the example shown in Fig. 6 (A) and Fig. 6 (B); The shape of the opening of stream 10 sides of the through hole that filter 32 is had and the opening of room 20 sides is with the slit-shaped of following direction as length direction, and this direction is meant: liquid under 12 situation about being imported into that enter the mouth liquid from 12 directions that flow to outlet 14 that enter the mouth.The slit width of the opening of stream 10 sides of the through hole that filter 32 is had and the opening of room 20 sides; Same with the fine particle separating device 3a that the variation of above-mentioned the 3rd embodiment is related, as can to utilize the size of the particle that fine particle separating device 4a separates to suit according to desire setting.
Fig. 7 (A) is the vertical view of the related fine particle separating device 4b of other variation of schematically illustrated the 4th embodiment, and Fig. 7 (B) is the cutaway view of the A-A line of Fig. 7 (A).
The fine particle separating device 4b that other variation of the 4th embodiment is related, be with the difference of the related fine particle separating device 4 of the 4th embodiment: stream 10 does not have outlet 14.That is, form following structure: except not through the particle of filter 32 and the solid phase, flow to room 20 via filter 32 from 12 liquid that import that enter the mouth etc.Like this, even do not have under outlet 14 the situation at stream 10, according to the same principle of content in " the 4. related fine particle separating device of the 4th embodiment " explanation in this, also play same effect.
In addition; Stream 10 does not have the structure of outlet 14; The related fine particle separating device 4a of variation to related fine particle separating device 3a of the variation of the related fine particle separating device 3 of first embodiment related fine particle separating device 1, second embodiment related fine particle separating device 2, the 3rd embodiment, the 3rd embodiment and the 4th embodiment also can be suitable equally, and play same effect.
Fig. 8 (A) is the vertical view of the related fine particle separating device 4c of other variation of schematically illustrated the 4th embodiment, and Fig. 8 (B) is the cutaway view of the A-A line of Fig. 8 (A).
The fine particle separating device 4c that other variation of the 4th embodiment is related, be with the difference of the related fine particle separating device 4 of the 4th embodiment: room 20 has inlet 22.That is, room 20 also can as be used for waiting for liquid from enter the mouth 22 flow to outlet 24 stream play a role.Through being used to promote the auxiliary liquid that flows in room 20, can suppress thus to lodge in room 20 through particle behind the filter 32 and solid phase from 22 importings that enter the mouth.
For the related fine particle separating device 4c of other variation of the 4th embodiment, according to the same principle of content in " the 4. related fine particle separating device of the 4th embodiment " explanation in this, also play same effect.
In addition; Room 20 has the structure of inlet 22; The related fine particle separating device 4a of variation to related fine particle separating device 3a of the variation of the related fine particle separating device 3 of first embodiment related fine particle separating device 1, second embodiment related fine particle separating device 2, the 3rd embodiment, the 3rd embodiment and the 4th embodiment also can be suitable equally, and have same effect.
6. the application examples of fine particle separating device
Fig. 9 is used for block diagram that the separation of particles system 100 that has used the related fine particle separating device 1 of first embodiment is described.In Fig. 9, white arrow illustrates flowing and pipe arrangement of liquid, and black arrow illustrates flowing of signal.
Separation of particles system 100 shown in Figure 9 comprises: particle dispersion liquid is with container 110, pump 112, fine particle separating device 1, returnable 114, returnable 116 and control part 150.
Particle dispersion liquid is communicated with the inlet 12 of fine particle separating device 1 via pump 112 with container 110.Accommodate the dispersion liquid that in liquid, is dispersed with solids at particle dispersion liquid in container 110.Pump 112 will particle dispersion liquid with container 110 in dispersion liquid that hold, that in liquid, be dispersed with solids see off to fine particle separating device 1.Returnable 116 is communicated with the outlet 24 of fine particle separating device 1.Returnable 116 is held the liquid of discharging from the outlet of fine particle separating device 1 24 etc.
That returnable 114 is held is 14 that be discharged from from the outlet of fine particle separating device 1, particle through filter 30 or liquid etc.For example,, can on returnable 114, valve be set utilizing fine particle separating device 1 to separate under the situation of monocyte, be used to add with monocyte induce into dendritic cell reagent, or carry out the culture medium exchange.And then when in returnable 114, monocyte being induced under the situation of dendritic cell, the internal face of returnable 114 preferably constitutes with structure or the material that dendritic cell is prone to peel off.For example, can use polytetrafluoroethylene (PTFE) waterproof material such as (teflon (registration marks)), have formations such as surperficial macromolecular organic compound of hydrophilic coating or inorganic compound, perhaps have the structure of small concavo-convex or small post (micropost) shape.
Control part 150 drives the vibration that signal is controlled piezoelectric element 40 through piezoelectric element 40 is supplied with.Control part 150 can utilize to have CPU (Central Processing Unit) and the computer of memory constitutes.
According to separation of particles system 100, can realize the separation of particles system that constitutes with closed system pipeline (line).And, can realize need not being used to reclaim not the separation of particles system of the special operation of the particulate through filter.
Though the example to having used the related fine particle separating device 1 of first embodiment is illustrated; But the fine particle separating device 4 that related fine particle separating device 3a, the 4th embodiment of the variation that equally also can use the related fine particle separating device 3 of the related fine particle separating device of second embodiment 2, the 3rd embodiment, the 3rd embodiment is related and the related fine particle separating device 4a of variation of the 4th embodiment, and play same effect.In addition, under the situation of the related fine particle separating device 4a of the variation of using related fine particle separating device 4 of the 4th embodiment and the 4th embodiment, the piezoelectric element of 150 pairs of formation filters 32 of control part is controlled.
Figure 10 is used for the block diagram that the 100a of separation of particles system to the related fine particle separating device 4b of the variation of having used the 4th embodiment describes.In Figure 10, white arrow illustrates flowing and pipe arrangement of liquid, and black arrow illustrates flowing of signal.The structure tag identical label identical to the separation of particles system of the fine particle separating device 1 related 100 with having used first embodiment, and omit its detailed description.
Used the 100a of separation of particles system of the related fine particle separating device 4b of the variation of the 4th embodiment; Therefore because fine particle separating device 4b does not have outlet 14, be with the difference of separation of particles system 100: do not have and go out 14 returnable 114 that are communicated with.And the control part 150 of the 100a of separation of particles system is with the difference of separation of particles system 100: the piezoelectric element to constituting filter 32 is controlled.
Can realize separation of particles system according to the 100a of separation of particles system with closed system pipeline formation.
Figure 11 is used for the block diagram that the 100b of separation of particles system to the related fine particle separating device 4c of the variation of having used the 4th embodiment describes.In Figure 11, white arrow illustrates flowing and pipe arrangement of liquid, and black arrow illustrates flowing of signal.The structure tag identical label identical to the separation of particles system of the fine particle separating device 1 related 100 with having used first embodiment, and omit its detailed description.
Used the 100b of separation of particles system of the related fine particle separating device 4c of the variation of the 4th embodiment; Therefore because fine particle separating device 4c has inlet 22, be with the difference of separation of particles system 100: have pump 120 and the auxiliary liquid that is communicated with inlet 22 via pump 120 with container 118.Accommodate the mobile auxiliary liquid that is used to promote in the room 20 at fine particle separating device 4c (for example, phosphate buffer etc.) in container 118 at auxiliary liquid.And the control part 150 of the 100b of separation of particles system is with the difference of separation of particles system 100: the piezoelectric element to constituting filter 32 is controlled.
According to the 100b of separation of particles system, can realize the separation of particles system that constitutes with the closed system pipeline.And, can realize need not being used to reclaim not the separation of particles system of the special operation of the particulate through filter.And then, through being used to promote the auxiliary liquid that flows in the room 20 of fine particle separating device 4c, can suppress thus to lodge in room 20 through particle behind the filter 32 and solid phase from 22 importings that enter the mouth.
In addition, above-mentioned embodiment and variation only are examples, are not limited thereto.For example, each embodiment and each variation can be with a plurality of combinations that suit.
The present invention is not limited to above-mentioned embodiment, can also carry out various distortion.For example, the present invention includes the identical in fact structure of explaining with embodiment (for example, function, method and the structure that comes to the same thing or purpose and the identical structure of effect) of structure.And, the present invention includes the structure of the part beyond the essence of the structure of in embodiment, explaining having been carried out displacement.And, the present invention includes with embodiment in the structure explained serve the same role the structure of effect, maybe can realize the structure of identical purpose.And, present invention resides in the structure that has increased known technology on the basis of the structure of explaining in the embodiment.

Claims (6)

1. a fine particle separating device is characterized in that, comprising:
Stream with inlet;
Room;
The filter that is communicated with said stream and said room; And
Make the piezoelectric element of said filter vibration.
2. fine particle separating device according to claim 1 is characterized in that,
Comprise that also the stream that forms said stream forms parts,
Said piezoelectric element is arranged at said stream and forms parts, and makes said filter vibration via said stream formation parts.
3. fine particle separating device according to claim 1 is characterized in that,
Also comprise through a part being connected the support that supports said piezoelectric element with the internal face of said stream with said piezoelectric element,
Said piezoelectric element is arranged in the said stream.
4. fine particle separating device according to claim 1 is characterized in that,
Said piezoelectric element and said filter join and are arranged in the said stream.
5. a fine particle separating device is characterized in that, comprising:
Stream with inlet;
Room; And
Constitute the filter that is communicated with and comprises piezoelectric element with said stream and said room.
6. according to each described fine particle separating device of claim 1 to 5, it is characterized in that,
Said stream has outlet.
CN2011103653843A 2010-11-19 2011-11-17 Fine particle separator Pending CN102527132A (en)

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