CN102500057A - Multifunctional implanted gastrointestinal electrical stimulation system - Google Patents
Multifunctional implanted gastrointestinal electrical stimulation system Download PDFInfo
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- CN102500057A CN102500057A CN2011102986134A CN201110298613A CN102500057A CN 102500057 A CN102500057 A CN 102500057A CN 2011102986134 A CN2011102986134 A CN 2011102986134A CN 201110298613 A CN201110298613 A CN 201110298613A CN 102500057 A CN102500057 A CN 102500057A
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Abstract
The invention provides a multifunctional implanted gastrointestinal electrical stimulation system in the technical field of medical apparatus and instruments. The system comprises an in-vivo implantation device and an in-vitro control device and has the functions of multichannel gastrointestinal electrical stimulation signal generation, in-vivo gastrointestinal track pressure detection, in-vivo gastrointestinal electrical detection and in-vitro wireless charging, wherein the in-vivo implantation device comprises an energy receiving coil, an implanted electrical stimulator, a stimulating electrode, a detection electrode and a minitype pressure sensor. According to the invention, the setting and regulation of electrical stimulation parameters and transmission of various control commands can be flexibly achieved through the wireless communication between the in-vitro control device and the in-vivo implantation device, and the in-vivo implantation device can transmit the in-vivo gastrointestinal track pressure and the gastrointestinal electrical detection result to the in-vitro control device in real time for receiving and storage. By using the system, the working life of a device can be greatly prolonged without frequently changing a battery when operation is carried out; and the limitation of the millisecond-stage impulse in the existing gastrointestinal stimulator is broken through, the intestinal pressure and intestinal electrical measurement accuracy can be improved, and convenience is provided for detecting or researching the effect of the gastrointestinal electric stimulation.
Description
Technical field
The present invention relates to a kind of implanted gastrointestinal electric stimulation; But relate in particular to a kind of wireless charging; Have the implanted gastrointestinal electric stimulation of gastrointestinal electricity irritation, gastrointestinal electrical signal detection and gastrointestinal cavity internal pressure signal testing function simultaneously, belong to technical field of medical instruments.
Background technology
Functional gastrointestinal disease is a common clinical, has data to show, functional gastrointestinal disorder has accounted for the over half of Gastroenterology dept.'s outpatient service.Because pathogenic factor and pathogeny are indeterminate, still lack ideal Therapeutic Method at present.In recent years; The gastrointestinal electrical stimulation method has received extensive concern; Lot of research and clinical trial have confirmed that it is to treatment of diseases effects such as gastroparesis, short intestinal disease, intestinal pseudo obstruction, fecal incontinence, constipation, obesity; Especially be regarded as the safe and effective means of the obstinate type gastroparesis of treatment in the gastroparesis field, had a good application prospect.
It is slow wave generation theory that the treatment principle of gastrointestinal electricity irritation derives from gastrointestinal pacemaker point current potential.The same with heart, also exist the electric pacemaker of nature in the gastrointestinal tract, different parts respectively has its inherent slow wave frequency, and the gastrointestinal contraction movement is controlled by slow wave just.Therefore in theory, the control slow wave can reach and correct unusual gastrointestinal electricity, the purpose of Regulation of Gastric intestinal motive force.The gastrointestinal electricity irritation is exactly to utilize impressed current directly or indirectly to act on pacemaker and effector thereof---the smooth muscle cell of each one of gastrointestinal tract, thereby makes intestinal recover the normal electric rhythm and pace of moving things and the motion of contracting of relaxing.Current in this field; During short term therapy, stimulating electrode generally links to each other with the stimulated in vitro device through passing subcutaneous electrode cable, and mostly the stimulated in vitro device is universal pulse signal generator if using; Then implantable nerve electrostimulators that adopt in long-term treatment more; Its structure and profile are all similar with cardiac pacemaker, and Core Feature is to realize electric pulse stimulation and remote control, as by the Enterra gastrointestinal electrostimulator of numerous gastroparesiss and U.S. Medtronic Inc. that bariatrician adopted.Owing to generally adopt lithium battery power supply, the working life of implanted electric stimulator by enforcement time of electricity irritation, implement frequency and relevant parameter decision, as life expectancy of Enterra device be 5～10 years.In case running down of battery then must be performed the operation once more and changed.This energy-provision way also makes existing implanted electric stimulator be difficult to provide low frequency high-amplitude long pulse and multi-lead stimulus signal, at present even do not have to produce an implantation type electric stimulation device of the above pulse width of 2ms.And have the scholar to think, and digestive organs mainly are made up of smooth muscle, and the responsive time constant of smooth muscle is about 100-300ms, and is much slow than nervous tissue, so the long pulse of ms level stimulates the function to changing these organs more effective.Typically, if the pulse pace-making, pulse width should be greater than 50ms.In the electric pace-making of small intestinal, pulse width should be at least 50-150ms.If signal is made up of train of pulse, then for the frequency of 40Hz, the pulse width that needs should be greater than 2ms, and is in the treatment of obesity, then higher to the requirement of broad pulse output.
In addition; Be to understand the curative effect of electrical stimulation method, implement electronic stimulation during, change situation that also must monitoring test object digestive tract power; Mainly shrink parameters such as wriggling, the gastrointestinal slow wave rhythm and pace of moving things or intestinal transmission time at present by means of gastrointestinal cavity internal pressure detector, Electrogastrograph meter or gastrointestinal emptying inspection method monitoring gastrointestinal; Exist the pilot system complicacy, with high costs, problems such as operation inconvenience; The summary of electrical stimulation method curative effect and the discussion of mechanism of action have been influenced greatly; Like the effect of gastrointestinal electricity irritation to the gastrointestinal contraction movement, the problems such as control of small intestinal, colon slow wave RD still there is not clear conclusions so far, secular human clinical's experiment more is difficult to carry out.
In sum, existing implanted electric stimulator function singleness, limited, the limited energy of pulse parameter range of accommodation far can not satisfy the needs of clinical treatment and research, becomes one of major obstacle that hinders the development of gastrointestinal electrical stimulation technology.
Summary of the invention
The objective of the invention is to deficiency to prior art; A kind of multi-functional implanted gastrointestinal electric stimulation that has the generation of multichannel gastrointestinal electrical stimulation signal, gastrointestinal cavity internal pressure signal detection, gastrointestinal electrical signal detection function simultaneously is provided; Be implanted into the radio communication between the device through external control device and body; Can realize the transmission of setting, adjustment and the operational order of electrical stimulation parameters flexibly; And send to external control device can be with gastrointestinal internal pressure, gastrointestinal electro-detection fructufy the time and receive and preserve, with the action effect of check gastrointestinal electricity irritation.Body is implanted into device and adopts the chargeable battery power supply, when battery capacity is lower than setting threshold, can be its wireless charging through the percutaneous energy transmission system.
According to an aspect of the present invention; A kind of multi-functional implanted gastrointestinal electric stimulation is provided; Comprise that body is implanted into device and external control device; Wherein, body is implanted into device and all implants, and is used under the control of external control device, implementing the gastrointestinal electricity irritation and detects gastrointestinal internal pressure and electromyographic signal; External control device is used for body is implanted into the remote control of device and receives the wireless receiving that detects data in the body of its emission preserving.
Particularly; For realizing such purpose, multi-functional implanted gastrointestinal electric stimulation of the present invention comprises that body is implanted into device and external control device, during use; Body is implanted into device and implants fully, has the function of output multichannel stimulus signal, detection gastrointestinal stress signal and the gastrointestinal signal of telecommunication; External control device works in external, is responsible for the interior wireless receiving that detects data of wireless transmission, body of setting, stimulus parameter and the control command of realization stimulus parameter and preserves and external wireless energy emission function.
Described body is implanted into device and comprises energy receiving coil, implanted electric stimulator, stimulating electrode, detecting electrode and micro pressure sensor; Wherein implanted electric stimulator is the small-sized sealing device of a band interface; Implant subcutaneously during use fully, energy receiving coil, stimulating electrode, detecting electrode and micro pressure sensor then are connected via wires to respectively on the interface of implanted electric stimulator.Implanted electric stimulator specifically comprises radio receiving transmitting module, stimulus signal generating module, pressure signal processing module, gastrointestinal signal of telecommunication processing module, in-body power source administration module, normally closed dry reed pipe and permanent magnet in stimulator shell, external interface, chargeable battery, charge management module, wireless energy receiver module, body inner control module, the body again.
Described energy receiving coil is a flat, and coil head is implanted subcutaneous abdomen during use, and the other end is connected via wires to the external interface of implanted electric stimulator.
Described stimulating electrode comprises the multi-electrode lead; One end of every electrode cable is connected in implanted electric stimulator, and the other end inserts gastrointestinal wall, uses the surgical thread sutured; The electric impulse signal that is used to transmit implanted electric stimulator output shrinks to promote gastrointestinal in the gastrointestinal pacemaker point.
Described detecting electrode comprises single electrode cable, and the needle-like head of electrode cable inserts gastrointestinal wall, and an end is connected to implanted electric stimulator, is used to detect the gastrointestinal electromyographic signal, and is sent to the signal processing module in the implanted electric stimulator.
The pressure that described micro pressure sensor is used to detect in the gastrointestinal cavity changes, and during use its responsive head is sutured on the gastrointestinal wall, and power line that links to each other with sensing unit and holding wire then are connected to the external interface of implanted electric stimulator.
Wireless energy receiver module in the described implanted electric stimulator links to each other with the energy receiving coil; Comprise rectification, filtering and mu balanced circuit, during wireless charging, the alternating voltage that the induction of energy receiving coil is produced converts DC voltage-stabilizing output into; Under non-charged state, no-voltage output.
Described charge management module comprises battery charging management chip and peripheral circuit.Under charged state; The induction electromotive force that the energy receiving coil produces provides the direct current input for charge management module behind wireless energy receiver module rectifying and wave-filtering; For chargeable battery charges; The exportable signal of charged state prompting pin of battery charging management chip is used for the judgement of charged state to body inner control module;
Described chargeable battery links to each other with the in-body power source administration module; Can adopt various types of rechargeable batteries; Should have smaller volume and higher capacity, be in non-charged state following time, for the in-body power source administration module power supply input is provided by chargeable battery at implanted electric stimulator; The in-body power source administration module then comprises a plurality of direct current regulation circuits, converts the output of chargeable battery in the implanted electric stimulator required direct-current working volts of other modules;
Described stimulus signal generating module is in vivo under the effect of control module; Can produce the adjustable electric impulse signal output of parameters such as multichannel amplitude, frequency, pulsewidth, persistent period; Can produce the stimulus waveform of pulse and two kinds of patterns of train of pulse, every road signal is separate.The stimulus signal generating module has multiple implementation; As adopt the method for programmable power supply and power amplification circuit; With the output of programmable power supply power supply as power amplification circuit; Then the original burst signal of body inner control module output becomes the stimulus signal of required amplitude, frequency and pulsewidth after power amplification circuit amplifies.Another kind method is to adopt the combination of D/A converter and operational amplification circuit, and D/A converter is the adjustable pulse signal of output amplitude under the control of control module in vivo, and after operational amplification circuit amplified, the pulse signal that produces final required amplitude was exported again;
Described pressure signal processing module comprises signal amplification circuit and A/D change-over circuit; Wherein signal amplification circuit is used to amplify the faint primary signal of micro pressure sensor output; The A/D change-over circuit is realized the analog digital conversion of amplified signal, so that body inner control module is gathered;
Described gastrointestinal signal of telecommunication processing module comprises signal amplification circuit, filter circuit and A/D change-over circuit, is used to realize amplification, filtering and the analog digital conversion of the gastrointestinal signal of telecommunication that detecting electrode is obtained;
Described body inner control module comprises microprocessor chip and peripheral circuit, is responsible for the realization and the conversion of control implanted electric stimulator each item function.After radio receiving transmitting module receives the stimulus parameter and command information of external control device transmission in control volume; Control stimulus signal generating module produces the electric impulse signal output of regulation parameter or reads the pressure signal processing module and the testing result of gastrointestinal signal of telecommunication processing module output, and radio receiving transmitting module outwards sends body internal pressure and checking with EMG method data in the control volume; Regularly detect the battery capacity (being embodied by cell voltage) of chargeable battery, when being lower than certain threshold value, radio receiving transmitting module outwards sends the charge prompting signal in the control volume.In battery charging process, the level that detects the charged state indication pin of charge management module changes, so that timely complete charge prevents to overcharge.
Described normally closed dry reed pipe and permanent magnet are formed the magnet controlled switch of implanted electric stimulator; Normally closed dry reed pipe is serially connected between chargeable battery and the in-body power source administration module; Permanent magnet is positioned over the stimulator shell near the normally closed dry reed pipe place, makes tongue tube under the permanent magnet effect, is in normally open; Do not constitute power circuit in the implanted electric stimulator; After permanent magnet took away from shell, normally closed dry reed pipe recovered closure state, and implanted electric stimulator promptly begins to work on power.
Described external control device then comprises external controller and energy transmitting coil, and the energy transmitting coil is connected via wires to external controller.External controller specifically comprises coil interface, human-machine interface module, LCD MODULE, real-time clock module, external control unit, external wireless communication module, data memory module, wireless energy transmitter module, external power management module and battery.
Described wireless energy transmitter module comprises DC-AC translation circuit and LC resonance circuit; Its outfan coils interface is connected with the energy transmitting coil; When charging in the body; Can produce the sinusoidal signal output of the certain amplitude of certain frequency, the excitation energy transmitting coil produces the alternating magnetic field of corresponding frequencies.
Described energy transmitting coil is flat; In when charging, coil head with binding agent fit to the energy i (in vivo) receiving coil on the skin surface of position, the other end is connected to coil interface; Under the non-charged state, then can take off from coil interface and skin.
Described human-machine interface module comprises keyboard input or touch screen input module or the various communication interface that links to each other with computer; Be used to set, revise the parameters and the input of control commands of stimulus signal; Wherein the parameter of adjustable stimulus waveform comprises amplitude, pulsewidth, frequency, persistent period, intermittent time, channel number etc.; The type of control command then comprises the transmission parameter, begins to stimulate, finishes to stimulate, begin orders such as detection, detection of end, system hibernates, and external control unit is through reading corresponding input command and stimulus parameter with the communication of human-machine interface module.
Described data memory module can adopt various types of data storage cards to constitute, and like mmc card, SD card etc., its input is connected to external control unit, and pressure, gastrointestinal electro-detection data that external control unit is transmitted are saved in the storage card.
Described external control unit links to each other with human-machine interface module, external wireless communication module, data memory module, LCD MODULE, wireless energy transmitter module, real-time clock module; Behind various stimulus parameters and control command that the personnel that receive through human-machine interface module are provided with, stimulus parameter or control command are wirelessly transmitted to the vivo implantation type electrostimulator through external wireless communication module.External wireless communication module sends external control unit to after receiving answer signal or gastrointestinal tract pressure, the checking with EMG method result of device in the body, by external control unit data is write data memory module.In charging process, control wireless energy transmitter module produces pumping signal output, and after receiving charging end information, control wireless energy transmitter module quits work.In system work process, can system status information, temporal information or testing result be shown to LCD MODULE in real time.
Compared with prior art, the present invention has following advantage: (1) adopts chargeable battery and wireless charging system as the energy resource supply mode of implanted electric stimulator, has prolonged the working life of installing greatly, need not often operation and changing battery; (2) under the competent situation of the energy, the boost pulse of the various waveforms of the exportable multichannel of implanted electric stimulator has been broken through the restriction of existing gastrointestinal irritation device Millisecond pulse, and stimulus modelity and stimulus parameter can be revised at any time flexibly simultaneously; (3) existing gastrointestinal electricity irritation product only has the function of output stimulus signal, and clinical staff is assessment, research therapeutic effect, also must be in addition by intracavity pressure tester or Electrogastrograph meter etc.; And native system integrated above-mentioned functions, when implementing the gastrointestinal electricity irritation, can synchronous recording gastrointestinal cavity internal pressure and body in the gastrointestinal signal of telecommunication; Simplified system's formation greatly; Reduced the treatment cost, improved the measurement accuracy, for the effect of check or research gastrointestinal electricity irritation provides very big convenience.
The present invention has gastrointestinal tract pressure detecting in the generation of multichannel gastrointestinal electrical stimulation signal, the body, the interior gastrointestinal electro-detection function of body simultaneously.During system works; Be implanted into the radio communication between the device through external control device and body; Can realize the transmission of setting, adjustment and the various control commands of electrical stimulation parameters flexibly; Body is implanted into device and sends to external control device also can be with gastrointestinal tract pressure in the body and gastrointestinal electro-detection fructufy the time and receive and preserve, with the action effect of check gastrointestinal electricity irritation.Body is implanted into device and adopts the chargeable battery power supply; And regularly detect the capacity of chargeable battery; When the chargeable battery capacity was lower than setting threshold, body was implanted into device and sends charge prompting information, is its wireless charging by the wireless energy transfer module in the external control device.
Description of drawings
Fig. 1 is an operation principle sketch map of the present invention;
Fig. 2 is the structural representation of vivo implantation type device;
Fig. 3 is the structural representation of external control device;
Fig. 4 is the principle schematic of wireless charging system.
Among the figure, body is implanted into radio receiving transmitting module 15, stimulus signal generating module 16, pressure signal processing module 17, gastrointestinal signal of telecommunication processing module 18, external interface 19, stimulator shell 20, external controller housing 21, external control unit 22, real-time clock module 23, human-machine interface module 24, LCD MODULE 25, data memory module 26, external wireless communication module 27, external power management module 28, battery 29, wireless energy transmitter module 30, coil interface 31, energy transmitting coil 32, external controller 33 in device 1, external control device 2, implanted electric stimulator 3, energy receiving coil 4, stimulating electrode 5, detecting electrode 6, micro pressure sensor 7, wireless energy receiver module 8, charge management module 9, chargeable battery 10, normally closed dry reed pipe 11, permanent magnet 12, in-body power source administration module 13, body inner control module 14, the body.
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment is to be to implement under the prerequisite with technical scheme of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, comprise that according to system provided by the invention body is implanted into device 1 and external control device 2, body all implants when being implanted into device 1 work, is used to implement the gastrointestinal electricity irritation and detects gastrointestinal internal pressure and electromyographic signal; External control device 2 is designed to portable, is used for that body is implanted into the wireless receiving that detects data in remote control and the body of device 1 and preserves.
As shown in Figure 2, described body is implanted into device 1 and comprises implanted electric stimulator 3, energy receiving coil 4, stimulating electrode 5, detecting electrode 6 and micro pressure sensor 7.After the implantation, the energy receiving coil 4 of implanted electric stimulator 3 and flat all is embedded in subcutaneous abdomen, and energy receiving coil 4 is wired to the external interface 19 of implanted electric stimulator 3.When being chargeable battery 10 chargings in the implanted electric stimulator 3, the energy receiving coil 4 externally effect of alternating magnetic field produces induced potential output down, inputs to implanted electric stimulator 3 through external interface 19.Stimulating electrode 5 comprises the multi-electrode lead; The needle-like head of every path electrode lead is sewn onto the stimulation location (or claiming the pace-making position) on the intestinal wall through surgical thread; The electrode cable other end then is connected to the external interface 19 of implanted electric stimulator 3; Be used for each pace-making position output electric stimulation pulse, the signal of each path electrode is separate, is independent of each other.Detecting electrode 6 is made up of 1 electrode cable, and the needle-like head of electrode cable is sewn onto the detection position on the intestinal wall through surgical thread, and the other end is connected to the external interface 19 of implanted electric stimulator 3, is used to gather the bioelectrical signals of intestinal wall; Micro pressure sensor 7 can adopt miniature diffuse si piezoresistive transducer; The sensor sensing head is sewn to the detection position on the intestinal wall; Be wired to the external interface 19 of implanted electric stimulator 3, be used to detect the enteric cavity internal pressure that causes because of intestinal peristalsis promoting and change.
Described implanted electric stimulator 3 be a volume small and exquisite, be easy to implant subcutaneous sealing device, specifically comprise radio receiving transmitting module 15, stimulus signal generating module 16, pressure signal processing module 17, gastrointestinal signal of telecommunication processing module 18, external interface 19 and stimulator shell 20 in the wireless energy receiver module 8, charge management module 9, chargeable battery 10, normally closed dry reed pipe 11, permanent magnet 12, in-body power source administration module 13, body inner control module 14, body.
Described stimulator shell 20 adopts nontoxic, corrosion-resistant and has the medical material of excellent compatibility to process with tissue, like titanium alloy material, other parts except that permanent magnet 12 in the implanted electric stimulator 3 is all sealed within it.Permanent magnet 12 is before implanted electric stimulator 3 is implanted; Be positioned on the stimulator shell 20 near near the position the inner normally closed dry reed pipe 11; Make normally closed dry reed pipe 11 inner reeds under the magneticaction of permanent magnet 12, be in off-state; Implanted electric stimulator 3 outages quit work; After implanting, permanent magnet 12 is taken away from stimulator shell 20, normally closed dry reed pipe 11 closures in the implanted electric stimulator 3, implanted electric stimulator 3 begins to work on power.
The input of described wireless energy receiver module 8 links to each other with energy receiving coil 2 through external interface 19; Outfan is connected to charge management module 9; Its effect is when wireless charging; Export DC voltage stably after the ac voltage rectifier filtering that energy receiving coil 2 is sensed, as the power supply input of charge management module 9.The outfan of charge management module 9 links to each other with chargeable battery 10; Utilization is chargeable battery 10 chargings from the dc source that wireless energy receiver module 8 obtains by the flow process of setting; The pin of the charged state of charge management module 9 indication simultaneously is connected to body inner control module 14; This pin is the output high level when charging, and charging finishes the back output low level, so that charged state is understood in body inner control module 14 monitoring in real time.Chargeable battery 10 is connected to the input of in-body power source administration module 13 through normally closed dry reed pipe 11; After permanent magnet 12 takes away from stimulator shell 20; Normally closed dry reed pipe 11 closed conductings provide the power supply input by chargeable battery 10 for in-body power source administration module 13.The outfan of in-body power source administration module 13 respectively with body inner control module 14, body in radio receiving transmitting module 15, stimulus signal generating module 16, pressure signal processing module 17, gastrointestinal signal of telecommunication processing module 18 and external interface 19 link to each other, for each module and micro pressure sensor 7 provide required dc source.The input of stimulus signal generating module 16 is connected with body inner control module 14; Outfan then is connected to external interface 19; Under the control of control module 14, produce the adjustable electric impulse signals of parameter such as frequency, amplitude, dutycycle, persistent period and output to stimulating electrode 5 in vivo through external interface 19; Radio receiving transmitting module 15 links to each other with body inner control module 14 in the body; Has the two-way wireless communication function; Stimulus signal parameter and various control command that the external control device that receives 2 is sent transmit donor inner control module 14, and gastrointestinal tract pressure, the checking with EMG method data with 14 outputs of body inner control module send to external control device 2 reception preservations simultaneously.The input of pressure signal processing module 17 links to each other with micro pressure sensor 7 through external interface 19; Outfan links to each other with body inner control module 14, after being used to amplify the primary signal of micro pressure sensor 7 outputs and converting digital signal to donor inner control module 14 is provided; The input of gastrointestinal signal of telecommunication processing module 18 is connected with detecting electrode 6 through external interface 19; Outfan links to each other with body inner control module 14; Be used for to the electromyographic signal of detecting electrode 6 output amplify, filtering and A/D conversion, and donor inner control module 14 is provided.
As shown in Figure 3, described external control device 2 comprises external controller 33 and energy transmitting coil 32.External controller 33 is a handheld apparatus; When needs charge for implanted electric stimulator 3; With the coiler part of flat energy transmitting coil 32 be fitted in subcutaneous energy receiving coil 4 on the skin surface of position, the other end then is wired to external controller 33.
Described external controller 33 specifically comprises external controller housing 21, external control unit 22, real-time clock module 23, human-machine interface module 24, LCD MODULE 25, data memory module 26, external wireless communication module 27, external power management module 28, battery 29, wireless energy transmitter module 30, coil interface 31, and external controller housing 21 all is packaged in inside with other parts.The input of external power management module 28 is connected with battery 29; Outfan then is connected with wireless energy transmitter module 30, real-time clock module 23, human-machine interface module 24, LCD MODULE 25, data memory module 26, external wireless communication module 27 and external control unit 22 respectively; After the voltage voltage stabilizing with battery 29 outputs, for each module provides dc source.
Described wireless energy transmitter module 30 outfan coils interfaces 31 are connected with energy transmitting coil 32; Input is connected to external control unit 22; After full bridge inverter carries out DC-AC conversion and power amplification, convert the pulse signal of external control unit 22 outputs the AC signal of certain amplitude and frequency to,, be sent to energy transmitting coil 32 again through the LC resonance circuit; Drive the alternating electromagnetic field that it produces same frequency on every side, body is implanted into device 1 carries out wireless charging.
Described external control unit 22 links to each other with human-machine interface module 24, is used to receive the control command that operator send.Human-machine interface module 24 is designed to matrix keyboard in the present embodiment; Comprise numeral keys and command key; Numeral keys is used to revise stimulus parameter, and command key is used for input operation order, as sending parameter, beginning to stimulate, finish to stimulate, begin in detection, detection of end, the body system hibernates etc.External control unit 22 reads the key command of human-machine interface module 24 through the mode of interrupt response.External control unit 22 and external wireless communication module 27 are connected through data communication interface; To send external wireless communication module 27 to from the personnel operation order that human-machine interface module 24 reads; And be wirelessly transmitted to implanted electric stimulator 3 by external wireless communication module 27, produce corresponding operation with control implanted electric stimulator 3.External wireless communication module 27 can send data to external control unit 22 through communication interface after the body internal pressure that receives implanted electric stimulator 3 transmissions, gastrointestinal electro-detection data simultaneously.External control unit 22 is connected with LCD MODULE 25, is used for the waveform of display system work state information, temporal information, detection signal; External control unit 22 is connected with real-time clock module 23, is used for reading corresponding temporal information after the data or being used on LCD MODULE 25 the display system working time etc. at each wireless receiving.External control unit 22 links to each other with data memory module 26, and the body internal pressure that at every turn receives, gastrointestinal electro-detection data together are saved in the storage card together with the real-time clock that reads from real-time clock module 23.
The present invention works in the following manner: permanent magnet 12 is taken away from stimulator shell 20; Be embedded in energy receiving coil 4 and implanted electric stimulator 3 subcutaneous through operation; The head of stimulating electrode 5, detecting electrode 6 and micro pressure sensor 7 utilizes surgical thread to be sewn onto on the gastrointestinal wall, and the other end is connected through the external interface 19 of lead and implanted electric stimulator 3.After body is implanted into device 1 operation and installs; The parameter of stimulus signal at first is set through the human-machine interface module 24 of external controller 33; Comprise stimulus modelity (pulse stimulates or train of pulse stimulates), amplitude, frequency, dutycycle, persistent period, stimulating electrode numbering etc.; Then stimulus parameter and stimulation order are sent in the body through external wireless communication module 27; Implanted electric stimulator 3, begins by pattern and the parameter output electric pulse signal set after stimulus parameter and order at wireless receiving.The situation of change of the gastrointestinal tract pressure or the gastrointestinal signal of telecommunication in medical personnel such as need understanding body this moment; Then send the corresponding data acquisition order to implanted electric stimulator 3 through external controller 33; Implanted electric stimulator 3 promptly begins detection bodies internal pressure and gastrointestinal electricity, and by the fixed cycle data wireless is sent to external controller 33 reception preservations.In the device work process; Implanted electric stimulator 3 regularly detects the voltage of chargeable battery 10, when cell voltage is low to moderate a certain threshold value, to the low signal of external transmission battery capacity; External controller 33 is shown to it on LCD MODULE 25 after receiving the prompting signal.At this moment; Operator fit to energy transmitting coil 32 on the skin surface of energy receiving coil 4 positions; External controller 33 open wireless energy transmitter modules 30 drive energy transmitting coil 32 and produce alternating electromagnetic field on every side, and subcutaneous energy receiving coil 4 is through electromagnetic coupled output induction electromotive force; Output dc voltage behind wireless energy receiver module 8 rectifying and wave-filterings in implanted electric stimulator 3 is again charged for chargeable battery 10 by charge management module 9.After charging finishes; Charge management module 10 output charging end signal to body inner control modules 14; Body inner control module 14 is that radio receiving transmitting module 15 sends the complete charge instruction in the control volume, and external controller 33 cuts out wireless energy transmitter module 30 after receiving this instruction; Operator take off energy transmitting coil 32, finish the wireless charging process.
Obviously, the above embodiment of the present invention only be for clearly the present invention is described and is done for example, but not the qualification of embodiment of the present invention.Here need not also can't give exhaustive to all implementation methods.And those belong to other embodiments that spirit of the present invention takes and are within protection scope of the present invention.
Claims (7)
1. multi-functional implanted gastrointestinal electric stimulation; It is characterized in that, comprise that body is implanted into device and external control device, wherein; Body is implanted into device and is used for all implanting, and under the control of external control device, implements the gastrointestinal electricity irritation and detects gastrointestinal internal pressure and electromyographic signal; External control device is used for that body is implanted into device to carry out remote control and carries out wireless receiving and preservation to detecting data in the body of its emission.
2. multi-functional implanted gastrointestinal electric stimulation according to claim 1; It is characterized in that; Said body is implanted into device and comprises energy receiving coil, implanted electric stimulator, stimulating electrode, detecting electrode and micro pressure sensor; Wherein,, the energy receiving coil is connected to implanted electric stimulator; Stimulating electrode comprises the multi-electrode lead, and the needle-like head of every path electrode lead is sewn onto the stimulation location on the intestinal wall, and the electrode cable other end then is connected to implanted electric stimulator, is used for each pace-making position output electric stimulation pulse; The needle-like head of detecting electrode is sewn onto the detection position on the intestinal wall, and the other end is connected to implanted electric stimulator, is used to gather the bioelectrical signals of intestinal wall; Micro pressure sensor is connected to implanted electric stimulator, is used to detect the enteric cavity internal pressure that causes because of intestinal peristalsis promoting and changes.
3. multi-functional implanted gastrointestinal electric stimulation according to claim 2; It is characterized in that; Said implanted electric stimulator comprises permanent magnet and stimulator shell; Also comprise the interior radio receiving transmitting module of external interface, chargeable battery, charge management module, wireless energy receiver module, body inner control module, body, stimulus signal generating module, pressure signal processing module, gastrointestinal signal of telecommunication processing module, in-body power source administration module and the normally closed dry reed pipe that are sealed in the stimulator shell; Wherein: the input of wireless energy receiver module links to each other with the energy receiving coil through external interface; Outfan is connected to charge management module, exports DC voltage stably after the ac voltage rectifier filtering with the output of energy receiving coil, as the power supply input of charge management module; The outfan of charge management module links to each other with chargeable battery, utilizes the dc source that obtains from the wireless energy receiver module to charge for chargeable battery by the flow process of setting, and the pin of the charged state of charge management module indication simultaneously is connected to body inner control module; Chargeable battery is connected to the input of in-body power source administration module through normally closed dry reed pipe; The outfan of in-body power source administration module respectively with body inner control module, body in radio receiving transmitting module, stimulus signal generating module, pressure signal processing module, gastrointestinal signal of telecommunication processing module and external interface link to each other, for each module and micro pressure sensor provide required dc source; The input of stimulus signal generating module is connected with body inner control module, and outfan is connected with external interface, under the control of control module, produces the adjustable electric impulse signal of parameter and outputs to stimulating electrode through external interface in vivo; Radio receiving transmitting module links to each other with body inner control module in the body; Be used for two-way wireless communication; Stimulus signal parameter and various control command that the external control device that receives is sent transmit donor inner control module, and cavity pressure, the gastrointestinal electro-detection data with the output of body inner control module send to external control device reception preservation simultaneously; The input of pressure signal processing module links to each other with micro pressure sensor through external interface, and outfan links to each other with body inner control module, and being used to amplify the primary signal of micro pressure sensor output and converting digital signal into provides donor inner control module; The input of gastrointestinal signal of telecommunication processing module is connected with detecting electrode through external interface, and outfan links to each other with body inner control module, be used for to the primary signal of detecting electrode output amplify, filtering, A/D conversion process, and donor inner control module is provided.
4. multi-functional implanted gastrointestinal electric stimulation according to claim 3; It is characterized in that the implanted electric stimulator shell adopts nontoxic, corrosion-resistant and has the medical material of excellent compatibility to process with tissue, implanted electric stimulator adopts magnetic switch control, and whether it works on power; Magnetic switch comprises permanent magnet and normally closed dry reed pipe; Permanent magnet was positioned on the stimulator shell near near the position the inner normally closed dry reed pipe before implanted electric stimulator is implanted, and made normally closed dry reed pipe be in off-state; The implanted electric stimulator outage quits work; After implanting, permanent magnet is taken away from the stimulator shell, implanted electric stimulator promptly begins to work on power.
5. multi-functional implanted gastrointestinal electric stimulation according to claim 1; It is characterized in that; External control device is used for the interior gastrointestinal tract pressure of the transmission that modification, external control command and stimulus parameter are set, body of stimulus parameter, the reception of gastrointestinal electro-detection data is preserved, and also is used to vivo implantation type device wireless charging; External control device comprises energy transmitting coil and external controller; External controller comprises external controller housing; Also comprise and be packaged in external controller housing inner external control unit, real-time clock module, human-machine interface module, LCD MODULE, data memory module, external wireless communication module, external power management module, battery, wireless energy transmitter module, coil interface and energy transmitting coil; Wherein: the input of external power management module is connected with battery; Outfan is connected with wireless energy transmitter module, real-time clock module, human-machine interface module, LCD MODULE, data memory module, external wireless communication module, external control unit respectively; After the voltage voltage stabilizing with battery output, for each module provides dc source; Wireless energy transmitter module coils interface is connected with the energy transmitting coil; The DC voltage of external power management module output is converted to the AC signal of certain amplitude and frequency; Drive the energy transmitting coil and produce alternating magnetic field, body is implanted into device carries out wireless charging; External control unit links to each other with human-machine interface module, is used for stimulus parameter and control command that the read operation personnel are provided with; External control unit is connected through data communication interface with external wireless communication module, will be wirelessly transmitted to implanted electric stimulator from personnel operation order and the stimulus parameter that human-machine interface module reads, and is used to control implanted electric stimulator and produces corresponding operation; External wireless communication module sends data to external control unit after the body internal pressure that receives the implanted electric stimulator transmission, gastrointestinal electro-detection data simultaneously; External control unit links to each other with LCD MODULE, is used for the waveform of display system work state information, temporal information, detection signal; External control unit is connected with real-time clock module, is used for reading corresponding temporal information after the data or being used on LCD MODULE the display system working time etc. at each wireless receiving; External control unit links to each other with data memory module, and the body internal pressure that at every turn receives, gastrointestinal electro-detection data are saved in the storage card together with the real-time clock that reads from real-time clock module.
6. multi-functional implanted gastrointestinal electric stimulation according to claim 1 is characterized in that, body is implanted into device and adopts chargeable battery work; External control device is its charging through wireless mode; Implanted electric stimulator regularly detects the voltage of chargeable battery, when cell voltage is low to moderate a certain threshold value, sends the low signal of battery capacity to external control device; After external control device receives the prompting signal, display reminding information on Liquid Crystal Module.
7. multi-functional implanted gastrointestinal electric stimulation according to claim 1; It is characterized in that; The adjustable electrical stimulation signal of parameter that the exportable multichannel of implanted electric stimulator is separate; After the implantation, through external controller with the wireless mode for the vivo implantation type electrostimulator is provided with different stimulus parameters, comprise stimulus modelity, pulse amplitude, frequency, dutycycle, persistent period, stimulating electrode numbering.
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