CN102475665A - Anti-aging cosmetic composition containing red algae extract - Google Patents
Anti-aging cosmetic composition containing red algae extract Download PDFInfo
- Publication number
- CN102475665A CN102475665A CN2011103878512A CN201110387851A CN102475665A CN 102475665 A CN102475665 A CN 102475665A CN 2011103878512 A CN2011103878512 A CN 2011103878512A CN 201110387851 A CN201110387851 A CN 201110387851A CN 102475665 A CN102475665 A CN 102475665A
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- China
- Prior art keywords
- skin
- cosmetic composition
- red algae
- algae extract
- wrinkle
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention relates to a cosmetic composition containing red algae extract as active ingredient. More specifically, the invention relates to an anti-aging cosmetic composition which contains red algae extract to help regeneration of epidermis and cortical skin to prevent skin wrinkle, thereby having great effect and high security.
Description
Technical field
The present invention relates to contain the cosmetic composition of red algae as effective ingredient, more detailed, relate to and contain red algae, thereby wrinkle of skin improves the very excellent aging resistance of the effect compositions that applies some make up.
Background technology
Skin is the first road protection net of human body, protects intravital organ to avoid the stimulation of external environment conditions such as variations in temperature, humidity variation, ultraviolet, public hazards material, and organism stable states such as thermoregulation are played an important role.So important skin also other internal organs with human body is the same aging gradually along with the increase at age, and phenomenons such as skin elasticity loss, keratinization, generation wrinkle, atrophoderma take place the result.The reason of this skin ageing phenomenon can roughly be divided into two kinds: and the genovariation of cell, tissue intrinsic factor such as variation and extrinsic factor such as ultraviolet, humidity (Masamitsu Ichihashi, Fragrance Journal, Vol.32, No.5,24-30).The catabiosis that particularly ultraviolet is caused is called photoaging, and known such photoaging phenomenon is to generate reactive oxygen free radical through ultraviolet at cell interior, and this active oxygen promotes the proteolytic enzyme (MMP-1 such as collagen, elastin laminin as the skin corium elastic fiber through the signal transduction system that causes inflammation; MMP-3, MMP-9 etc.) synthetic (Fisher G.J.et al., Nature; Vol.379; 335-339), thereby reduce the elasticity of skin corium, bring out wrinkle of skin.
Therefore, in order to prevent such skin ageing phenomenon and keep more healthy and resilient skin that people make great efforts to develop has the biological active substances that improves the wrinkle effect always.Representational have: receive the U.S. FDA permission at trans retinoic acid of nineteen ninety-five (trans-retinoic acid) as the therapeutic agent of the skin that is used to improve photoaging; Retinol than its few side effects begins to be used for cosmetic material in nineteen ninety for middle and late stage, thereby the cosmetics that improve wrinkle begin formally to come into the market.After this, type estrogen substance, the antioxidant that from each kind of plant, extracts etc. are incorporated in the cosmetics as the raw material that improves wrinkle.
But such cosmetic material major part exists effect very little or bring out variety of issues such as skin side-effects.In addition; Even if the raw material that effect is good; Present cosmetic material is applicable to being limited in scope of skin; Most of the effect that skin is caused is similar in order to promote that collagen is synthetic, suppress collagen decomposition, to remove active oxygen and so on, can not satisfy fully to hope to upgrade and fundamentally improve the client's of wrinkle requirement more by force and further.For this reason, to studying the skin aging mechanism that makes new advances based on up-to-date skin scientific theory and its cut-out or the raw material that delays and Study on Technology being carried out in the cosmetics industry actively.
Keratinocyte in the skin and fibroblast are because stress, outside harmful factor, endogenous are aging etc. multiple former thereby sustain damage and degenerate; Its density reduces; Wherein, The keratinocyte that particularly inside and outside property pressure causes and fibroblastic damage finally reduce the density of Skin Cell and hinder the synthetic of elastic fiber and make the skin texture collapse, and wrinkle is deepened.For example, the keratinocyte of skin sustains damage and reduces the cell density of epidermis, and fibroblast sustains damage and destroys collagen.These aspects are integrated see; Think and to carry out good management for nursing skin wrinkle fundamentally; The keratinocyte that exists in the skin and fibroblast are not damaged because of inside and outside property pressure etc. and degenerate; If received damage, then need dock the technology that to repair immediately.
Summary of the invention
For this reason; Inventor of the present invention for develop do not bring out skin side-effects, from natural component, prevent that skin aging and wrinkle from improving the excellent cosmetics of effect and study repeatedly; The result learns that the composition from seaweeds has skin and improves effect, particularly finds to help Skin Cell regeneration from the composition of red algae, compares with existing cosmetics; Can improve wrinkle of skin greatly, thereby accomplish the present invention.
Therefore, the purpose of this invention is to provide and help Skin Cell regeneration and embody aging resistance that excellent wrinkle of skin the improves effect compositions that applies some make up.
To achieve these goals, the present invention provides and contains the red algae extract as the aging resistance of the effective ingredient compositions that applies some make up.
The aging resistance of the present invention compositions that applies some make up promotes collagen synthetic; Help keratinocyte and fibroblastic regeneration of damage or aged skin; Fundamentally prevent wrinkle of skin, thereby show that remarkable wrinkle of skin improves effect, also excellent to skin safety simultaneously.
Description of drawings
Fig. 1 is to damaging after the figure that the influence that keratinocyte brought of exhaust-gas treatment is represented with the mobile variation of keratinocyte with OSMOGELINE.
Fig. 2 be with OSMOGELINE to damage after the figure that the influence that fibroblast brought that hydrocortisone is handled is represented with fibroblastic mobile variation.
The specific embodiment
The present invention provides and contains the red algae extract as the aging resistance of the effective ingredient compositions that applies some make up.
Used in the present invention include red algae seaweed
, Gracilaria
, Eucheuma
, stab Eucheuma
, linear soft spines algae
, seaweed, Sea grass, tenax
, intends feathers vegetables
, Japanese thorn shield algae
, Gracilaria
, Long Branch Sand dish
, trigeminal cents dish
, Bourdon cents dish
, hook condensate dish
and centipedes algae
, etc., which may be mixed with one or more, but is not limited thereto.
The effect excellence of the influence of injurious factors such as the keratinocyte of the composition of red algae extract protection skin is avoided with fibroblast wearing out, environmental pollution, stress, external pressure, toxin; Keratinocyte and fibroblastic regeneration to damage play a significant role, thereby suppress the damage of the Skin Cell that aging, pressure, outside injurious factor causes.In addition, through promoting fibroblastic regeneration, it is synthetic in skin, to increase collagen, thereby increases the elastic fiber of dermal layer of the skin, has the effect of improvement, mitigation wrinkle.
Though said extract is not limited thereto, can make with following method for distilling.For example; Can use that more than one algae that will be selected from the red algae are leached, fried
and the leachate that obtains, but also can use leachate is concentrated a part or the concentrate that all obtains or said concentrate is dry again and preserved material
, decoct
, lozenge
and mobile concentrated solution
that make again.
In addition; The manufacturing approach of said leachate is not limited thereto; For example can be with red algaes such as Eucheuma gelatinosum, Thallus Porphyrae, Digenea simplex (Wnlf.) C. Ag. with arbitrary method such as natural drying or force drying drying and after being cut into filament; With being selected from anhydrous or aqueous alcohol, acetone, ethyl acetate, chloroform, glycerol, propylene glycol and the butanediol of water, C1-C4 more than one, leaching through arbitrary method such as merceration, diafiltration (percolation), hot dippings and handle the extractum that obtains containing effective ingredient as solvent.
The red algae extract that uses among the present invention preferably contains 0.0001-25 weight % with respect to the cosmetic composition gross weight, during less than 0.0001 weight %, can not get required effect, when surpassing 25 weight %, possibly bring out skin irritation.
Can contain on cosmetic conduct and learning or the skin science admissible medium or base and dosage formization according to cosmetic composition of the present invention.It comprises the whole dosage forms that are fit to local use; Can provide with following form; For example with solution, gel, solid, the anhydrous product of pasty state, disperse oil phase and Emulsion, suspension, microemulsion, microcapsule, subparticle ball or the ion-type (liposome) and the form of nonionic folliculus dispersion that obtain at aqueous phase, the perhaps form of frost, astringent, skin cream, powder, ointment, spraying or the screening flaw excellent
.In addition, can also use with the form of foam (foam) or the form of aerosol composition that further contains the propellant of compression.These compositionss can be made according to method well known in the art.
In addition, can contain normally used adjuvant in cosmetic conduct and learning or the skin scientific domain that fatty material, organic solvent, lytic agent, concentrating agents, gelating agent, softening agent, antioxidant, suspension, stabilizing agent, foaming agent (foaming agent), aromatic, surfactant, water, ion-type or nonionic emulsifier, filler, metal ion block normally used other composition and so on arbitrarily in agent, chelating agen, preservative agent, vitamin, blocker, wetting agent, essential oil, dyestuff, pigment, hydrophilic or lipophile activator, lipid folliculus or the cosmetics according to cosmetic composition of the present invention.Said adjuvant is introduced with the general amount of using in cosmetic conduct and learning or the skin scientific domain.
Below, through embodiment and Test Example content of the present invention is described more specifically.These embodiment just point out in order to understand content of the present invention, and interest field of the present invention is not limited by these embodiment, can carry out in this area generally well-known distortion, displacement and insertion etc., and these are also included within the scope of the present invention.
Reference example 1
The red algae extract that uses in this experiment is the complex (complex) that is purchased, and name of product is an OSMOGELINE (manufacturer: BASF), temperature, pH are stablized, put in the dosage form at low temperatures.
Test Example 1 collagen synthesizes facilitation effect
After the HF cultivated in the dull and stereotyped incubator in 24 holes, respectively with contain 0,1,5, the culture medium of the red algae extract (OSMOGELINE) of 10ppm concentration replaces.Cultivated the 3rd day, and after the adding of every hole contains each 0.5ml of DMEM culture medium of 10% hyclone, added L [2,3,4,5-3H]-proline 10 μ Ci.After 24 hours, collect culture medium and cell in each hole, 5% trichloroacetic acid (TCA packs into; Trichloroacetic acid) wash in the solution after, divide and to annotate in 2 test tubes, in 1 test tube, add type i collagen enzyme (type I collagenase) 1 unit/μ l, cultivated 90 minutes at 37 ℃, another test tube is stored in 4 ℃.Then, in all test tubes, add each 0.05ml of 50% trichloroacetic acid, 4 ℃ of held after 20 minutes, respectively with 12,000rpm centrifugalize 10 minutes, with each supernatant and precipitate with liquid scintillation counter (LSC; Liquid Scintillation Counter) obtains count per minute (CPM; Count Per Minute) value according to following mathematical expression 1, is measured relative collagen biosynthesis value (RCB to matched group and experimental group; Relative Collagen Biosynthesis), and with its result be shown in the following table 1.
Mathematical expression 1
Table 1
| The concentration of red algae extract (ppm) | Collagen biosynthesis value (RCB) (%) relatively |
| 10 | 145 |
| 5 | 124 |
| 1 | 109 |
| 0 (matched group) | 100 |
As appreciable in the above-mentioned table 1, can know that red algae extract concentrations dependency ground increases fibroblastic collagen biosynthesis.
Mobile experiment in Test Example 2 keratinocytes
In order to estimate the damage defence and the regeneration capacity of the keratinocyte (epidermis) that the OSMOGELINE that uses among the present invention causes waste gas, carry out moving (migration) experiment in the keratinocyte according to following experimental technique.
1. in 6 orifice plates, add 4 * 10
5The HaCaT cell, culture medium is used DMEM (adding 10%FBS).At 37 ℃ of CO
2Cultivated 24 hours in the incubator.
2. with 0.1% OSMOGELINE experimental group was handled 6 hours.
3. induce damage with the sharp cell scraping of white fin (white tip), matched group and experimental group are all handled from the sample of automobile exhaust mouth with gathering.
4. after the inducing cell damage, utilize optical microscope (50 * multiplying power) to take pictures immediately, take pictures after 12 hours again, the cell of comparative experiments group and matched group moves variation.
The method of using in the said experimental technique from automobile exhaust mouth collection sample is following, the cotton rod of the matter utilization of the air vent that is bonded at the Korando car is gathered, and be dissolved among the DMSO, utilizes 0.4 μ M pin type filter (syringe filter) to filter.The result is shown in Fig. 1.
As shown in Figure 1, only relatively poor relatively with the keratinocyte injury recovery of the matched group of exhaust-gas treatment, and damage expands other cell of periphery to.On the contrary, the result according to experimental group can confirm that handling through OSMOGELINE can promotion damage location regeneration in the cell injury that defence waste gas causes.
Mobile experiment in Test Example 3 fibroblasts
In order to estimate in the present invention the OSMOGELINE that uses damage defence and regeneration capacity, be carried out to according to following experimental technique and move (migration) experiment in the fibrocyte the fibroblast (corium) that causes by hydrocortisone.The result is shown among Fig. 2.
1. in 6 orifice plates, add 2 * 10
5Normal person fibroblast (noraml human fibroblast), culture medium is used DMEM (adding 10%FBS).At 37 ℃ of CO
2Cultivated 24 hours in the incubator.
2. with 0.1% OSMOGELINE experimental group was handled 6 hours.
3. induce damage with the sharp cell scraping of white fin (white tip), matched group and experimental group are all handled cell with hydrocortisone 10 μ M.
4. after the inducing cell damage just and after 12 hours, utilize phase contrast microscope (50 * multiplying power) to take pictures comparative result.
As shown in Figure 2; The fibroblast of the matched group of only handling with hydrocortisone has obtained the result that injury recovery postpones, and in contrast, can confirm according to the result of experimental group; Handle through OSMOGELINE, the injury recovery delaying state that stress hormone (hydrocortisone) causes improves relatively.
Embodiment 1 and comparative example 1-2
The composition of following table 2 has been made the embodiment 1 and comparative example 1-3 of the skin cream dosage form of emulsion form.
Table 2
The manufacturing approach of embodiment 1 and comparative example 1-3
1. in pure water, add EDTA-2Na, glycerol and butanediol, be heated to 70 ℃.
2. the oil of tristerin, cetearyl alcohol, arachidic alcohol and arachidic alcohol glucoside, the pure and mild cetearyl glucoside of cetearyl alcohol, vegetalitas squalane, spermol ethylhexoate and wax are heated to 80 ℃ and dissolve.
3. carry out emulsifying in said 1 the aqueous solution
while slowly adding with said 2.
4. in said 3, add carbomer, make its tackify after, add triethanolamine, antiseptic, spice, pigment, mix homogeneously postcooling to 50 ℃.
5. in said 4, add OSMOGELINE, Thallus Laminariae (Thallus Eckloniae) extract, the mixing of Entermorpha extract evenly.
Test Example 4 wrinkles improve effect assessment
For the wrinkle of understanding said embodiment 1 and comparative example 1-3 improves effect, experimentize as follows.20-40 year 80 of women are divided into 4 groups; Every group each 20; Every day, sooner or later 2 skin creams at specified around eyes separate application embodiment 1 and comparative example 1-3 were made the imitation plate (replica) of silicon material after 8 weeks, with the state of the wrinkle of appointed part with image analyzer visibility meter (visiometer:SV60; Courage+Khazaka electronic GmbH Germany) measures.Its result is shown in following table 3, and this result representes to deduct each parameter (parameter) value separately after 8 weeks the average of preceding parameter value of 8 weeks.That is, this value shows negative more, and it is high more that the expression wrinkle improves effect.
Table 3
| Distinguish | R1 | R2 | R3 | R4 | R5 |
| Embodiment 1 | -0.30 | -0.21 | -0.14 | -0.10 | -0.09 |
| Comparative example 1 | 0.06 | 0.05 | 0.02 | -0.01 | ?0.00 |
| Comparative example 2 | -0.10 | -0.07 | -0.04 | -0.05 | -0.03 |
| Comparative example 3 | -0.12 | -0.07 | -0.04 | -0.03 | -0.03 |
R1: the difference of isocontour peak of wrinkle and minimum
R2: the wrinkle equal pitch contour is divided into the average of wherein R1 value behind 5 lattice arbitrarily
R3: with the peak in per 5 the R1 values of dividing into groups
R4: from the isocontour baseline of wrinkle (baseline), deduct separately peak value and the meansigma methods of valley
R5: the meansigma methods that from the isocontour baseline of wrinkle, deducts the value of each wrinkle profile
Shown in said table 3; Can know according to embodiments of the invention 1 and the comparative example that does not contain any effective ingredient 1, the comparative example 2 that contains the Thallus Laminariae (Thallus Eckloniae) extract of Brown algae, the comparative example 3 that contains the Entermorpha extract of green algae and compare that the effect of improving wrinkle of skin is remarkable.
The evaluation of 5 pairs of skin stability of Test Example
In order to confirm the cutaneous safety of the present composition, be called the patch test that objects (average 32.5 years old) are coated with embodiment 1 and comparative example 1-3 with 18 of adult females and male 12, estimate skin stability to compositions of the present invention.
Assay method is after attaching paster, after 28 hours, to remove paster, implements after 30 minutes to judge for the first time and reads, and after 96 hours, implements the 2nd judgement and reads.In order to understand the skin irritant intensity of sample, give weight according to the positive reaction degree of skin, obtain skin average response property, judge the skin irritation of sample through naked eyes.Its result is shown in following table 4.
Table 4
| Substances | Average response property | Judge grade |
| Embodiment 1 | 0.000 | Non-stimulated |
| Comparative example 1 | 0.000 | Non-stimulated |
| Comparative example 2 | 0.000 | Non-stimulated |
| Comparative example 3 | 0.000 | Non-stimulated |
By knowing among the result of said table 4, embodiment 1 and comparative example 1-3 all do not cause stimulation to skin.
Therefore, can judge the excellent in stability of cosmetic composition of the present invention to skin.
Claims (4)
1. aging resistance compositions that applies some make up is characterized in that said composition contains the red algae extract as effective ingredient.
2. cosmetic composition according to claim 1, wherein, said red algae extract contains with respect to the amount of composition total weight with 0.0001-25 weight %.
3. cosmetic composition according to claim 1; Wherein, said red algae extract be selected from Eucheuma gelatinosum, Gracilaria tenuistipitata, Eucheuma muricatum (Gmel.) Web.Van Bos., Eucheuma spinosum, linear Chondracanthus Kuetzing, Thallus Porphyrae, Digenea simplex (Wnlf.) C. Ag., Gloiopeltis tenax, Pterocladiella capillacea, Acanthopeltis japonica, Gracilaria tenuistipitata, Hypnea Charoides, Ceramium kondoi, Ceramium boydenii, Campylaephora hypnaeoides and the Grateloupia filicina (Wulf.) more than a kind.
4. cosmetic composition according to claim 1, wherein, said compositions is the biosynthetic cosmetic composition that promotes collagen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020100120161A KR101781556B1 (en) | 2010-11-30 | 2010-11-30 | Cosmetic composition for anti-aging containing red algae extracts |
| KR10-2010-0120161 | 2010-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102475665A true CN102475665A (en) | 2012-05-30 |
Family
ID=46088523
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103878512A Pending CN102475665A (en) | 2010-11-30 | 2011-11-29 | Anti-aging cosmetic composition containing red algae extract |
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|---|---|
| KR (1) | KR101781556B1 (en) |
| CN (1) | CN102475665A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721068A (en) * | 2015-01-29 | 2015-06-24 | 广州暨南生物医药研究开发基地有限公司 | Application of eucheuma gelatinae polysaccharide in preparation of antioxidant skin care products |
| CN106619239A (en) * | 2016-12-16 | 2017-05-10 | 广东芭薇生物科技股份有限公司 | Red algae extract-containing composition and application thereof |
| US9687442B2 (en) | 2015-07-27 | 2017-06-27 | Mary Kay Inc. | Topical skin formulations |
| CN110613664A (en) * | 2019-10-28 | 2019-12-27 | 海南女人春天美容有限公司 | Soothing massage cream and preparation method thereof |
| CN111228210A (en) * | 2020-04-02 | 2020-06-05 | 广州一一生物技术有限公司 | Composition for repairing skin barrier and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721068A (en) * | 2015-01-29 | 2015-06-24 | 广州暨南生物医药研究开发基地有限公司 | Application of eucheuma gelatinae polysaccharide in preparation of antioxidant skin care products |
| US9687442B2 (en) | 2015-07-27 | 2017-06-27 | Mary Kay Inc. | Topical skin formulations |
| US10052278B2 (en) | 2015-07-27 | 2018-08-21 | Mary Kay Inc. | Topical skin formulations |
| US10201495B2 (en) | 2015-07-27 | 2019-02-12 | Mary Kay Inc. | Topical skin formulations |
| US10869821B2 (en) | 2015-07-27 | 2020-12-22 | Mary Kay Inc. | Topical skin formulations |
| US11577099B2 (en) | 2015-07-27 | 2023-02-14 | Mary Kay Inc. | Topical skin formulations |
| US11911635B2 (en) | 2015-07-27 | 2024-02-27 | Mary Kay Inc. | Topical skin formulations |
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| CN110613664A (en) * | 2019-10-28 | 2019-12-27 | 海南女人春天美容有限公司 | Soothing massage cream and preparation method thereof |
| CN111228210A (en) * | 2020-04-02 | 2020-06-05 | 广州一一生物技术有限公司 | Composition for repairing skin barrier and preparation method and application thereof |
| CN111228210B (en) * | 2020-04-02 | 2021-02-09 | 广州一一生物技术有限公司 | Composition for repairing skin barrier and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101781556B1 (en) | 2017-09-27 |
| KR20120058737A (en) | 2012-06-08 |
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Application publication date: 20120530 |