CN102441232A - Implanted bladder function repairing system - Google Patents
Implanted bladder function repairing system Download PDFInfo
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- CN102441232A CN102441232A CN2011102810495A CN201110281049A CN102441232A CN 102441232 A CN102441232 A CN 102441232A CN 2011102810495 A CN2011102810495 A CN 2011102810495A CN 201110281049 A CN201110281049 A CN 201110281049A CN 102441232 A CN102441232 A CN 102441232A
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Abstract
The invention relates to an implanted bladder function repairing system, comprising an electrode, a nerve signal amplifier, a nerve signal processing circuit and a nerve electronic stimulator, wherein the electrode is fit with a sacral nerve root sleeve; the electrode is connected with the nerve signal amplifier and used for sending the nerve electrical signal received from a sacral nerve posterior root in the sacral nerve root sleeve to the nerve signal amplifier to be amplified; the nerve signal amplifier is connected with the nerve signal processing circuit and used for sending the amplified nerve electrical signal to the nerve signal processing circuit to be processed; the nerve signal processing circuit determines whether a human body needs to urinate according to the amplified nerve electrical signal, and sending a urinating signal to the connected nerve electronic stimulator if the human body needs to urinate; the nerve electronic stimulator sends a simulating electrical signal to the connected electrode according to the urinating signal; and the electrode stimulates the sacral nerve root sleeve by the simulating electrical signal to cause the sacral nerve in the sacral nerve root sleeve to control a bladder to urinate by the anterior root. The implanted bladder function repairing system can help patients to urinate as required.
Description
Technical field
The present invention relates to implantable medical electronic system technology field, particularly relate to a kind of implanted bladder function repair system.
Background technology
Spinal cord injury is the wound of serious harm human health, the quality of life that complication such as its caused neurogenic bladder, paraplegia, infection, decubital ulcer have seriously reduced sufferer, has improved its medical expense.In spinal cord injury, neurogenic bladder can cause complication such as secular urinary system infection, renal failure, has become one of patients with spinal cord injury life and health and has threatened greatly.
Fig. 1 is the nervous system sketch map of urinating relevant with bladder.As shown in Figure 1, root 101 behind the root 102 and sacral nerves is extended before the sacral nerves at the intravital cone of people 103 places, and the two converges in horse hair 104 edges is one, is called sacral nerve roots sleeve 1012, and the end of this sacral nerve roots sleeve 1012 connects bladder 105.Anatomical research proves; Though behind the sacral nerves before root 101 and the sacral nerves root 102 be a sacral nerve roots sleeve 1012 in 104 outside converging of horse hair, this sacral nerve roots sleeve 1012 is separable, can through the means of dissecting with its subdivision for root behind the sacral nerves independently and sacral nerves before root; And behind the sacral nerves at institute subdivision place root just with horse hair 104 in sacral nerves after root 101 link to each other; Before the sacral nerves at subdivision place root also with horse hair 104 in sacral nerves before root 102 link to each other, therefore, can think like this; Though behind the sacral nerves before root 101 and the sacral nerves root 102 be combined into sacral nerve roots sleeve 1012 at horse hair 104 foreign exchanges, the two is still and works alone.
Root behind the sacral nerves (comprising the outside part of part and horse hair 104 in the horse hair 104) is used for to cone 103 transmission electroneurographic signal; This electroneurographic signal can reflect the filling degree of bladder 105; Root before the sacral nerves (comprising the outside part of part and horse hair 104 in the horse hair 104) then is used for to inner muscle (sphincter of urethra and detrusor of bladder) the transmission stimulus signal of bladder 105, and this stimulus signal can stimulate bladder 105 to urinate.
For the sufferer of suffering from neurogenic bladder; Nervous pathway between its bladder 105 and the cone 103 (being root 102 and sacral nerve roots sleeve 1012 that the two merges before the root 101 behind the sacral nerves among Fig. 1, sacral nerves) is obstructed; Like this; Above-mentioned electroneurographic signal or stimulus signal just can not transmit between the muscle of cone 103 and bladder 105, thereby sufferer also just can not automatic micturition, thereby cause complication such as secular urinary system infection, renal failure.
Existing bladder function repair system is to help it through the mode of the sacral nerve roots sleeve 1012 that regularly stimulates sufferer urinate; Thereby sufferer can only be urinated in the time of confirming every day; This mechanism of urinating both can't guarantee that sufferer in time urinated when needs are urinated, also can't guarantee can discharge urine (sufferer possibly drink water less and do not have urine) in the urination time sufferer that confirm every day.
Summary of the invention
Technical problem to be solved by this invention provides a kind of implanted bladder function repair system, can help sufferer to urinate as required.
The technical scheme that the present invention solves the problems of the technologies described above is following: a kind of implanted bladder function repair system, and this system comprises: electrode, nerve signal amplifier, nerve signal treatment circuit, nerve electric stimulation device; Wherein,
Said electrode and sacral nerve roots sleeve are fitted;
Said electrode links to each other with said nerve signal amplifier, is used for that the electroneurographic signal of root behind the sacral nerves that is received from said sacral nerve roots sleeve is sent to said nerve signal amplifier and amplifies;
Said nerve signal amplifier links to each other with said nerve signal treatment circuit, is used for that the electroneurographic signal after its amplification is sent to said nerve signal treatment circuit and handles;
The electroneurographic signal of said nerve signal treatment circuit after according to said amplification confirmed human body, and whether needs are urinated, if then send the signal of urinating to the said nerve electric stimulation device that is connected;
Said nerve electric stimulation device sends the stimulation signal of telecommunication according to the said signal of urinating to the said electrode that connects; Said electrode utilizes the said stimulation signal of telecommunication that said sacral nerve roots sleeve is stimulated, and the preceding root control of sacral nerves bladder is wherein urinated.
The invention has the beneficial effects as follows: among the present invention; Electrode can be in real time or is periodically received the electroneurographic signal that root sent behind the sacral nerves in the sacral nerve roots sleeve, and is sent to the nerve signal amplifier and amplifies, and the nerve signal treatment circuit can be confirmed the filling degree of bladder according to the electroneurographic signal after amplifying; Thereby confirm whether human body need urinate; When definite human body need be urinated, nerve signal treatment circuit neurad electrostimulator in real time sent the signal of urinating, and being sent to electrode by the nerve electric stimulation device stimulates the signal of telecommunication; Thereby the sacral nerve roots sleeve is stimulated, the preceding root control of sacral nerves bladder is wherein urinated.Therefore; When the present invention can more in the urine that the sufferer intravesical accumulates (promptly need urinate), stimulate bladder to urinate immediately, thereby help sufferer to urinate as required; Prevent that urine from accumulating intravesical, reduce or eliminate the generation of complication such as urinary system infection, renal failure.
On the basis of technique scheme, the present invention can also do following improvement:
Further, also comprise transceiver and coupling coil;
Said transceiver links to each other respectively with said nerve signal treatment circuit with said coupling coil;
Said nerve signal treatment circuit is used for, with the electroneurographic signal after the said amplification of record, send to the signal and send to said transceiver corresponding writing time of urinating of said nerve electric stimulation device;
The electroneurographic signal of said transceiver after, the said signal and send to external circuit through said coupling coil corresponding writing time of urinating with said amplification.
Further, also comprise battery and electric power management circuit;
Said battery links to each other with said electric power management circuit;
After the unidirectional current that said electric power management circuit is sent here said battery carries out voltage stabilizing, offer coupled said nerve signal amplifier, nerve signal treatment circuit, transceiver and said nerve electric stimulation device respectively.
Further, said battery is a rechargeable battery;
This system also comprises AC/DC changeover switch, and it links to each other with said battery with said coupling coil respectively, is used for converting the alternating current that coupling coil obtains through coupled modes from said external circuit into unidirectional current and offers said battery.
Further, said nerve signal amplifier, nerve signal treatment circuit, nerve electric stimulation device, transceiver, AC/DC changeover switch, electric power management circuit are integrated in the chip;
Said chip is positioned on the printed circuit board (PCB);
Said coupling coil and said battery are positioned on the said printed circuit board (PCB).
Further, on the said printed circuit board (PCB) fixing hole is arranged;
This system also comprises to be passed said fixing hole and is fixed on the medical screw on the said sacral nerve roots sleeve cortical bone on every side.
Further, said coupling coil also is used for, and receives the control signal that said external circuit sends through coupled modes, and sends it to said transceiver;
Said transceiver also is used for, and said control signal is forwarded to said nerve signal treatment circuit;
Said nerve signal treatment circuit also is used for, and according to said control signal, regulates the frequency and/or the amplitude of the said stimulation signal of telecommunication of said nerve electric stimulation device transmission through changing the said signal of urinating.
Further, said electrode comprises: transmitting-receiving electrode points, reference electrode limit, substrate, lead; Wherein,
The quantity of said lead equals the quantity sum of said transmitting-receiving electrode points and said reference electrode limit;
Said transmitting-receiving electrode points and said sacral nerve roots sleeve are fitted; And link to each other with said nerve electric stimulation device with said nerve signal amplifier respectively through said lead; Be used for to be received from that the electroneurographic signal of root sends to said nerve signal amplifier behind the sacral nerves of said sacral nerve roots sleeve, and the said stimulation signal of telecommunication that utilizes said nerve electric stimulation device to send here stimulates to said sacral nerve roots sleeve;
Said reference electrode limit links to each other with said nerve electric stimulation device with said nerve signal amplifier respectively through said lead, is used for to said nerve signal amplifier and said nerve electric stimulation device reference potential being provided;
Said substrate is planar; Said transmitting-receiving electrode points and reference electrode limit all are covered on said substrate surface, and it is inner that said lead is positioned at said substrate.
Further, said transmitting-receiving electrode points, reference electrode limit and said lead are the gold system;
The surface of said transmitting-receiving electrode points and said reference electrode limit all applies iridium.
Further, the said substrate outside part of removing beyond said transmitting-receiving electrode points and the said reference electrode limit is enclosed with the clad material that C type Parylene is processed.
Further, the edge of said substrate is provided with plural sewing hole.
Further, said transmitting-receiving electrode points is one, and said reference electrode limit is four, and said lead is five;
Said transmitting-receiving electrode points is positioned at the end of said substrate surface;
Said reference electrode limit disperses to surround said transmitting-receiving electrode points, and and the distance of said transmitting-receiving electrode points all between 1mm to 2mm.
Further, whether the frequency of the electroneurographic signal of said nerve signal treatment circuit after according to said amplification surpasses the preset frequency threshold value and confirms human body whether needs are urinated.
Further, the said stimulation signal of telecommunication comprises the low frequency signal of telecommunication and high frequency electrical signal;
Said nerve electric stimulation device sends the said low frequency signal of telecommunication to said electrode earlier according to the said signal of urinating, and sends said high frequency electrical signal to said electrode again;
Said electrode utilizes the said low frequency signal of telecommunication that said sacral nerve roots sleeve is stimulated, and makes the preceding root control of sacral nerves sphincter of urethra contraction wherein and makes its fatigue;
Said electrode utilizes said high frequency electrical signal that said sacral nerve roots sleeve is stimulated, and the preceding root control of sacral nerves detrusor of bladder is wherein shunk, thereby urinate.
Description of drawings
Fig. 1 is the nervous system sketch map of urinating relevant with bladder;
Fig. 2 is the structure chart of the implanted bladder function repair system of the present invention's proposition;
Fig. 3 is the structure chart of the embodiment of the implanted bladder function repair system of the present invention's proposition;
Fig. 4 is with the position view in Fig. 3 embodiment implant into body.
The specific embodiment
Below in conjunction with accompanying drawing principle of the present invention and characteristic are described, institute gives an actual example and only is used to explain the present invention, is not to be used to limit scope of the present invention.
Fig. 2 is the structure chart of the implanted bladder function repair system of the present invention's proposition.As shown in Figure 2, this system comprises: electrode 201, nerve signal amplifier 202, nerve signal treatment circuit 203 and nerve electric stimulation device 204; Wherein,
Nerve signal treatment circuit 203 can be confirmed human body according to the electroneurographic signal after amplifying, and whether needs are urinated, if then send the signal of urinating to the nerve electric stimulation device that is connected 204, otherwise just neurad electrostimulator 204 does not send the signal of urinating.Here; Nerve signal treatment circuit 203 is whether the frequency according to the electroneurographic signal after amplifying surpasses the preset frequency threshold value and confirm human body whether needs are urinated; If the frequency of the electroneurographic signal after amplifying surpasses the preset frequency threshold value; Then definite human body need be urinated, and surpasses the preset frequency threshold value if the frequency of the electroneurographic signal after amplifying is less, and then definite human body need not urinated.The preset frequency threshold value here is a predetermined frequencies value, can regulate according to the needs of different human body.
Nerve electric stimulation device 204 is according to urinating signal; Promptly sending to the electrode that connects 201 stimulates the signal of telecommunication, and like this, electrode 201 just can utilize this stimulation signal of telecommunication that sacral nerve roots sleeve 1012 is stimulated; Root control bladder is urinated before making sacral nerves wherein, thereby realizes urinating as required of human body.
This shows that among the present invention, electrode can be in real time or periodically received the electroneurographic signal that root sent behind the sacral nerves in the sacral nerve roots sleeve; And be sent to the nerve signal amplifier and amplify; The nerve signal treatment circuit can be confirmed the filling degree of bladder according to the electroneurographic signal after amplifying, thereby confirms whether human body need urinate, when definite human body need be urinated; Nerve signal treatment circuit neurad electrostimulator in real time sends the signal of urinating; Send the stimulation signal of telecommunication by the nerve electric stimulation device to electrode, thereby the sacral nerve roots sleeve is stimulated, the preceding root control of sacral nerves bladder is wherein urinated.Therefore; When the present invention can more in the urine that the sufferer intravesical accumulates (promptly need urinate), stimulate bladder to urinate immediately, thereby help sufferer to urinate as required; Prevent that urine from accumulating intravesical, reduce or eliminate the generation of complication such as urinary system infection, renal failure.
According to human physiology's research, nerve electric stimulation device 204 sends to the stimulation signal of telecommunication of electrode 201, i.e. the stimulation signal of telecommunication that stimulates of the 201 pairs of sacral nerve rootses of electrode sleeve 1012; Can comprise the low frequency signal of telecommunication and high frequency electrical signal, nerve electric stimulation device 204 sends the low frequency signal of telecommunication to electrode 201 earlier according to urinating signal; Send high frequency electrical signal to electrode 201 again; The persistent period of the two can be regulated as required, and for example, the signal packet of urinating that nerve signal treatment circuit 203 sends contains the persistent period information of the low frequency signal of telecommunication and high frequency electrical signal; Like this; Nerve electric stimulation device 204 just can successively send the low frequency signal of telecommunication and the high frequency electrical signal of corresponding persistent period length to electrode 201 according to this persistent period information in the signal of urinating, thus the time span that control is urinated.
As shown in Figure 2; This system also comprises transceiver 205 and coupling coil 206; The transceiver 205 here can be realized with a signal receiving/transmission device; Also can realize with signal receiver and sender unit respectively, the device of coupling coil 206 here for utilizing coupled modes and external circuit 207 to communicate, available coil is realized.
Nerve signal treatment circuit 203 is used for; With the electroneurographic signal after the amplification of record, send to the signal and send to transceiver 205 corresponding writing time (being the transmitting time of the writing time of electroneurographic signal and the signal of urinating) of urinating of nerve electric stimulation device 204; Like this; Transceiver 205 just can supply external circuit 207 to carry out analyzing and processing the electroneurographic signal after amplifying, the signal and send to external circuit 207 through coupling coil 206 corresponding writing time of urinating.
As shown in Figure 2, this system also comprises battery 209 and electric power management circuit 210;
Wherein, Battery 209 links to each other with electric power management circuit 210; Electric power management circuit 210 can carry out voltage stabilizing to the unidirectional current that battery 209 is sent here; Then, electric power management circuit 210 offers coupled nerve signal amplifier 202, nerve signal treatment circuit 203, transceiver 205 and nerve electric stimulation device 204 respectively with the unidirectional current after the voltage stabilizing, and supply line is the represented circuit of the dotted line among Fig. 2.
The electric power management circuit 210 here is except carrying out voltage stabilizing and neurad signal amplifier 202, nerve signal treatment circuit 203, transceiver 205,204 power supplies of nerve electric stimulation device to unidirectional current; Can also detect the dump energy of battery 209; And judge whether this dump energy can keep this system works to preset time; If judged result be can not, then electric power management circuit 210 sends the electric weight alert signals with neurad signal processing circuit 203, after nerve signal treatment circuit 203 is received this signal; Can immediately or wait for a period of time the back to transceiver 205 transmission electric weight shortage signal, thereby cry for help to external circuit 207 through coupling coil 206.Certainly, electric power management circuit 210 is judging that dump energy is not enough to keep system works after the scheduled time, also can directly send the electric weight alert signals to transceiver 205, is cried for help to external circuit 207 through coupling coil 206 by it.
Can be to the insufficient treatment measures of battery 209 electric weight for it is charged, like this, this battery 209 just need be realized with rechargeable battery.
As shown in Figure 2; This system also comprises AC/DC changeover switch 208; It links to each other with battery 209 with coupling coil 206 respectively, is used for converting the alternating current that coupling coil 206 obtains through coupled modes from external circuit 207 into unidirectional current and offers battery 209 and store.
The amplitude of the stimulus signal that existing bladder function repair system applies sacral nerve roots sleeve 1012, frequency etc. all are predetermined; Can not change because of the people; Thereby in practical clinical; Sufferer is usually because of the amplitude and the excessive severe complications such as lower limb tic, pain, cerebrospinal leak, infection that take place of frequency of stimulus signal, perhaps because of the amplitude of stimulus signal or frequency is too small can not normal voiding.Information transmission between the present invention's coupling coil 206 capable of using and the external circuit 207 solves this problem.
Among the present invention, coupling coil 206 can be used for, and receives the control signal that external circuit 207 sends through coupled modes; And send it to transceiver 205, like this, transceiver 205 also is used for; Control signal is forwarded to nerve signal treatment circuit 203; Then nerve signal treatment circuit 203 also is used for, according to this control signal, through change frequency and/or the amplitude that signal regulates the stimulation signal of telecommunication that nerve electric stimulation device 204 sends of urinating.Like this; Through external circuit 207 is parameters such as scalable electrode 201 frequency that stimulates the stimulation signal of telecommunication of sacral nerve rootses sleeve 1012, amplitude; Make its needs that adapt to human body, prevent severe complications such as lower limb tic, pain, cerebrospinal leak, infection and because of the too small problem that can not normal voiding of the amplitude of stimulus signal or frequency.
The present invention is the medical electrical of implanted; It is positioned near the bladder of human body, and fits with sacral nerve roots sleeve 1012, thus its volume and power consumption all should be as far as possible little; With the histoorgan around preventing to damage, and use the long as far as possible time and need not to change.Thereby the nerve signal amplifier 202 among the present invention, nerve signal treatment circuit 203, nerve electric stimulation device 204, transceiver 205, AC/DC changeover switch 208, electric power management circuit 210 can be integrated in the chip; This chip can be arranged on the printed circuit board (PCB); And coupling coil 206 and battery 209 also be arranged on this printed circuit board (PCB); Thereby dwindle the volume of this system as much as possible, reduce its power consumption, satisfy the requirement of implantable medical electronic system.
Fig. 3 is the structure chart of this system implementation example.As shown in Figure 3; The label of above-mentioned chip is 302; The label of printed circuit board (PCB) is 301, and coupling coil 304 and battery 303 link to each other through corresponding circuit on corresponding lead and the chip 302 respectively, and be concrete; Coupling coil 304 links to each other respectively with transceiver, AC/DC changeover switch in the chip 302, battery 303 respectively with chip 302 in AC/DC changeover switch link to each other with electric power management circuit.
Among this embodiment; Printed circuit board (PCB) 301 is provided with fixing hole 305; Like this; This system medical screw capable of using with this printed circuit board (PCB) 301 and on chip 302, battery 303 and coupling coil 304 be fixed in around the inside of human body sacral nerve roots sleeve, thereby realize the static relatively of this system and human body, prevent that printed circuit board (PCB) 301 and each circuit from causing damage to human body.Concrete, can medical screw be passed fixing hole 305, and be fixed on the cortical bone around the sacral nerve roots sleeve 1012.
As shown in Figure 3, the electrode among the present invention comprises: transmitting-receiving electrode points 307, reference electrode limit 308, substrate 306, lead 311.Wherein, the quantity of lead 311 equals to receive and dispatch the quantity sum of electrode points 307 and reference electrode limit 308, and shown in Fig. 3 embodiment, this electrode comprises a transmitting-receiving electrode points 307 and four reference electrode limits 308, thereby the quantity of lead 311 just is five.
Transmitting-receiving electrode points 307 is fitted with the sacral nerve roots sleeve; And the lead through its connection links to each other with the nerve electric stimulation device with (in the chip 302) nerve signal amplifier respectively; Be used for to be received from that the electroneurographic signal of root sends to the nerve signal amplifier behind the sacral nerves of sacral nerve roots sleeve, and the stimulation signal of telecommunication that utilizes the nerve electric stimulation device to send here stimulates to the sacral nerve roots sleeve.
As shown in Figure 3; Transmitting-receiving electrode points 307 and reference electrode limit 308 all are positioned at an end 309 (another termination printed circuit board (PCB) 302 of substrate 306) of substrate 306; This end 309 is a triangle, can reduce the contact area of substrate 306 and human body, reaches the purpose that prevents this system injury human body.
Above-mentioned transmitting-receiving electrode points 307, reference electrode limit 308 and lead 311 are the gold system.Lead 311 is positioned at substrate 306 inside; Thereby can receive the protection of substrate 306; And transmitting-receiving electrode points 307 is covered on substrate 306 surfaces with reference electrode limit 308; Thereby in reception and when the sacral nerve roots sleeve sends the stimulation signal of telecommunication, self also can receive this stimulation action of electric signals and break away from substrate 306, thereby can all apply iridium on the surface of transmitting-receiving electrode points 307 and reference electrode limit 308; These iridium can prevent to receive and dispatch electrode points 307 and break away from substrate 306 surfaces with reference electrode limit 308 as the decorative material on transmitting-receiving electrode points 307 and reference electrode limit 308 surfaces.
Above-mentioned substrate 306 can be processed with flexibility and the good polyimides flexible polymeric materials of biocompatibility; Substrate 306 outsides are removed transmitting-receiving electrode points 307 and are enclosed with the clad material that C type Parylene is processed with reference electrode limit 308 part in addition, thereby avoid the damage of electrode pair human body as much as possible.
Among Fig. 3, transmitting-receiving electrode points 307 is one, and reference electrode limit 308 is four, and lead 311 is five;
Transmitting-receiving electrode points 307 is positioned at 309 places, end on substrate 306 surfaces;
Certainly, reference electrode limit 308 also can be other numbers with the number of transmitting-receiving electrode points 307, and for example, transmitting-receiving electrode points 307 can be more than one, and reference electrode limit 308 also can be one, or is other numbers, and its current potential that provides is as the zero potential of whole system.
Fig. 4 is with the position view in Fig. 3 embodiment implant into body.As shown in Figure 4, owing to substrate 306 employing flexible materials are processed, thereby can be crooked in human body, make the below of end 309, the applying that realizes receiving and dispatching electrode points 307 and sacral nerve roots sleeve 1012 through sacral nerve roots sleeve 1012 among Fig. 4.Available one medical screw passes the fixing hole 305 on the printed circuit board (PCB) 301, and is fixed together with sacral nerve roots sleeve 1012 cortical bone on every side, realizes fixing printed circuit board (PCB) 301.Can also pass the sewing hole 310 (preferentially passing the 3101-3104 among Fig. 3) among Fig. 3 with medical suture, and be stitched together, realize fixing substrate 306 with sacral nerve roots sleeve 1012 cortical bone on every side.
This Figure only shows the situation in the implanted bladder function repair system implant into body; According to the information that anatomy provided; The symmetry that sacral nerve roots sleeve 1012 has on the anatomic, thereby can be implanted into even number (for example two) implanted bladder function repair system provided by the invention at human body, these systems are symmetrically distributed in the both sides of sacral nerve roots sleeve 1012; Thereby realize control simultaneously, realize urinating as required of human body bladder both sides muscle.
This shows that the present invention has the following advantages:
(1) among the present invention; Electrode can be in real time or is periodically received the electroneurographic signal that root sent behind the sacral nerves in the sacral nerve roots sleeve, and is sent to the nerve signal amplifier and amplifies, and the nerve signal treatment circuit can be confirmed the filling degree of bladder according to the electroneurographic signal after amplifying; Thereby confirm whether human body need urinate; When definite human body need be urinated, nerve signal treatment circuit neurad electrostimulator in real time sent the signal of urinating, and being sent to electrode by the nerve electric stimulation device stimulates the signal of telecommunication; Thereby the sacral nerve roots sleeve is stimulated, the preceding root control of sacral nerves bladder is wherein urinated.Therefore; When the present invention can more in the urine that the sufferer intravesical accumulates (promptly need urinate), stimulate bladder to urinate immediately, thereby help sufferer to urinate as required; Prevent that urine from accumulating intravesical, reduce or eliminate the generation of complication such as urinary system infection, renal failure.
(2) among the present invention; Utilize the coupling of coupling coil and external circuit; Be the parameters such as frequency, amplitude of the stimulation signal of telecommunication of scalable electrode stimulating sacral nerve roots sleeve; Make its needs that adapt to human body, prevent severe complications such as lower limb tic, pain, cerebrospinal leak, infection and because of the too small problem that can not normal voiding of the amplitude of stimulus signal or frequency.
(3) the nerve signal amplifier among the present invention, nerve signal treatment circuit, nerve electric stimulation device, transceiver, AC/DC changeover switch and electric power management circuit are integrated in the chip; This chip can be arranged on the printed circuit board (PCB); And coupling coil and battery also be arranged on this printed circuit board (PCB); Can dwindle the volume of this system, reduce its power consumption, satisfy the requirement of implantable medical electronic system.
(4) among the present invention; On printed circuit board (PCB), be provided with fixing hole, in substrate, be provided with sewing hole, can realize the fixing of printed circuit board (PCB) and the relative human body of substrate; The end of substrate is set to triangle; Can reduce the area that contacts with human tissue organ, the contact area that this all helps reducing system provided by the invention and human body prevents its damage human body.
(5) utilize the present invention can simulate normal bladder urinary function; And; Because coupling coil can communicate with external circuit, thereby the present invention has the automatic early-warning ability, can realize spinal cord injury patient freedom, controllability, urinate near the control under the physiological status; Simultaneously, the present invention helps to inquire into feasibility and the mechanism that the sacral nerves signal of telecommunication imports mechanism and pattern and bladder function reparation chip into, for the electronic stimulation theory of neurogenic bladder provides new foundation.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (14)
1. an implanted bladder function repair system is characterized in that this system comprises: electrode, nerve signal amplifier, nerve signal treatment circuit, nerve electric stimulation device; Wherein,
Said electrode and sacral nerve roots sleeve are fitted;
Said electrode links to each other with said nerve signal amplifier, is used for that the electroneurographic signal of root behind the sacral nerves that is received from said sacral nerve roots sleeve is sent to said nerve signal amplifier and amplifies;
Said nerve signal amplifier links to each other with said nerve signal treatment circuit, is used for that the electroneurographic signal after its amplification is sent to said nerve signal treatment circuit and handles;
The electroneurographic signal of said nerve signal treatment circuit after according to said amplification confirmed human body, and whether needs are urinated, if then send the signal of urinating to the said nerve electric stimulation device that is connected;
Said nerve electric stimulation device sends the stimulation signal of telecommunication according to the said signal of urinating to the said electrode that connects; Said electrode utilizes the said stimulation signal of telecommunication that said sacral nerve roots sleeve is stimulated, and the preceding root control of sacral nerves bladder is wherein urinated.
2. system according to claim 1 is characterized in that, also comprises transceiver and coupling coil;
Said transceiver links to each other respectively with said nerve signal treatment circuit with said coupling coil;
Said nerve signal treatment circuit is used for, with the electroneurographic signal after the said amplification of record, send to the signal and send to said transceiver corresponding writing time of urinating of said nerve electric stimulation device;
The electroneurographic signal of said transceiver after, the said signal and send to external circuit through said coupling coil corresponding writing time of urinating with said amplification.
3. system according to claim 2 is characterized in that, also comprises battery and electric power management circuit;
Said battery links to each other with said electric power management circuit;
After the unidirectional current that said electric power management circuit is sent here said battery carries out voltage stabilizing, offer coupled said nerve signal amplifier, nerve signal treatment circuit, transceiver and said nerve electric stimulation device respectively.
4. system according to claim 3 is characterized in that, said battery is a rechargeable battery;
This system also comprises AC/DC changeover switch, and it links to each other with said battery with said coupling coil respectively, is used for converting the alternating current that coupling coil obtains through coupled modes from said external circuit into unidirectional current and offers said battery.
5. system according to claim 4 is characterized in that, said nerve signal amplifier, nerve signal treatment circuit, nerve electric stimulation device, transceiver, AC/DC changeover switch, electric power management circuit are integrated in the chip;
Said chip is positioned on the printed circuit board (PCB);
Said coupling coil and said battery are positioned on the said printed circuit board (PCB).
6. system according to claim 5 is characterized in that, on the said printed circuit board (PCB) fixing hole is arranged;
This system also comprises to be passed said fixing hole and is fixed on the medical screw on the said sacral nerve roots sleeve cortical bone on every side.
7. system according to claim 2 is characterized in that said coupling coil also is used for, and receives the control signal that said external circuit sends through coupled modes, and sends it to said transceiver;
Said transceiver also is used for, and said control signal is forwarded to said nerve signal treatment circuit;
Said nerve signal treatment circuit also is used for, and according to said control signal, regulates the frequency and/or the amplitude of the said stimulation signal of telecommunication of said nerve electric stimulation device transmission through changing the said signal of urinating.
8. system according to claim 1 is characterized in that, said electrode comprises: transmitting-receiving electrode points, reference electrode limit, substrate, lead; Wherein,
The quantity of said lead equals the quantity sum of said transmitting-receiving electrode points and said reference electrode limit;
Said transmitting-receiving electrode points and said sacral nerve roots sleeve are fitted; And link to each other with said nerve electric stimulation device with said nerve signal amplifier respectively through said lead; Be used for to be received from that the electroneurographic signal of root sends to said nerve signal amplifier behind the sacral nerves of said sacral nerve roots sleeve, and the said stimulation signal of telecommunication that utilizes said nerve electric stimulation device to send here stimulates to said sacral nerve roots sleeve;
Said reference electrode limit links to each other with said nerve electric stimulation device with said nerve signal amplifier respectively through said lead, is used for to said nerve signal amplifier and said nerve electric stimulation device reference potential being provided;
Said substrate is planar; Said transmitting-receiving electrode points and reference electrode limit all are covered on said substrate surface, and it is inner that said lead is positioned at said substrate.
9. system according to claim 8 is characterized in that, said transmitting-receiving electrode points, reference electrode limit and said lead are the gold system;
The surface of said transmitting-receiving electrode points and said reference electrode limit all applies iridium.
10. system according to claim 8 is characterized in that, the part that remove beyond said transmitting-receiving electrode points and the said reference electrode limit said substrate outside is enclosed with the clad material that C type Parylene is processed.
11. system according to claim 8 is characterized in that, the edge of said substrate is provided with plural sewing hole.
12. system according to claim 8 is characterized in that, said transmitting-receiving electrode points is one, and said reference electrode limit is four, and said lead is five;
Said transmitting-receiving electrode points is positioned at the end of said substrate surface;
Said reference electrode limit disperses to surround said transmitting-receiving electrode points, and and the distance of said transmitting-receiving electrode points all between 1mm to 2mm.
13. system according to claim 1 is characterized in that, whether the frequency of the electroneurographic signal of said nerve signal treatment circuit after according to said amplification surpasses the preset frequency threshold value is confirmed human body whether needs is urinated.
14. system according to claim 1 is characterized in that, the said stimulation signal of telecommunication comprises the low frequency signal of telecommunication and high frequency electrical signal;
Said nerve electric stimulation device sends the said low frequency signal of telecommunication to said electrode earlier according to the said signal of urinating, and sends said high frequency electrical signal to said electrode again;
Said electrode utilizes the said low frequency signal of telecommunication that said sacral nerve roots sleeve is stimulated, and makes the preceding root control of sacral nerves sphincter of urethra contraction wherein and makes its fatigue;
Said electrode utilizes said high frequency electrical signal that said sacral nerve roots sleeve is stimulated, and the preceding root control of sacral nerves detrusor of bladder is wherein shunk, thereby urinate.
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| CN2011102810495A CN102441232A (en) | 2011-09-21 | 2011-09-21 | Implanted bladder function repairing system |
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| CN2011102810495A CN102441232A (en) | 2011-09-21 | 2011-09-21 | Implanted bladder function repairing system |
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| CN106964068A (en) * | 2017-01-13 | 2017-07-21 | 北京品驰医疗设备有限公司 | A kind of adjusting method of the frequency of stimulation of sacral nerve stimulator |
| CN107050644A (en) * | 2017-01-13 | 2017-08-18 | 北京品驰医疗设备有限公司 | A kind of sacral nerve stimulation device of frequency of stimulation change |
| CN107743408A (en) * | 2015-08-05 | 2018-02-27 | 波士顿科学医学有限公司 | Control bladder function is paced using high frequency |
| CN109420252A (en) * | 2017-08-22 | 2019-03-05 | 精能医学股份有限公司 | Electrical stimulation device, the method and computer readable storage medium for generating electric signal |
| CN110327548A (en) * | 2019-08-08 | 2019-10-15 | 吉林大学 | A kind of Sacral nerve electrical stimulation system |
| CN111008610A (en) * | 2019-12-16 | 2020-04-14 | 哈尔滨工业大学 | Information-related brain potential induction experimental method |
| CN111298291A (en) * | 2020-03-20 | 2020-06-19 | 北京航空航天大学 | Autonomous urination auxiliary device and method |
| CN111683599A (en) * | 2017-12-21 | 2020-09-18 | 因卡伯实验室有限责任公司 | Device and method for sensing bladder fullness |
| US11786158B2 (en) | 2017-12-21 | 2023-10-17 | Incube Labs, Llc | Devices and methods for sensing bladder fullness |
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| CN109420252A (en) * | 2017-08-22 | 2019-03-05 | 精能医学股份有限公司 | Electrical stimulation device, the method and computer readable storage medium for generating electric signal |
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| CN110327548A (en) * | 2019-08-08 | 2019-10-15 | 吉林大学 | A kind of Sacral nerve electrical stimulation system |
| CN111008610A (en) * | 2019-12-16 | 2020-04-14 | 哈尔滨工业大学 | Information-related brain potential induction experimental method |
| CN111008610B (en) * | 2019-12-16 | 2024-03-22 | 哈尔滨工业大学 | Information-related brain potential evoked experiment method |
| CN111298291A (en) * | 2020-03-20 | 2020-06-19 | 北京航空航天大学 | Autonomous urination auxiliary device and method |
| CN111298291B (en) * | 2020-03-20 | 2021-10-08 | 北京航空航天大学 | Autonomous urination auxiliary device and method |
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Application publication date: 20120509 |